MCID: LYM010
MIFTS: 41

Lymph Node Tuberculosis

Categories: Immune diseases, Infectious diseases

Aliases & Classifications for Lymph Node Tuberculosis

MalaCards integrated aliases for Lymph Node Tuberculosis:

Name: Lymph Node Tuberculosis 12 15 17 71
King's Evil 12 44 71
Scrofula 12 71
Tuberculous Lymphadenopathy 12
Tuberculosis, Lymph Node 44
Tuberculous Adenitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4889
NCIt 50 C26896
SNOMED-CT 67 10893003
ICD10 32 A18.2
UMLS 71 C0036467 C0041316 C0242830

Summaries for Lymph Node Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that is located in lymph node, and has symptom lymphadenopathy, has symptom fever, has symptom weight loss, has symptom fatigue, has symptom night sweats and has symptom cough.

MalaCards based summary : Lymph Node Tuberculosis, also known as king's evil, is related to tuberculous peritonitis and mycobacterium tuberculosis 1, and has symptoms including fatigue, fever and cough. An important gene associated with Lymph Node Tuberculosis is SP110 (SP110 Nuclear Body Protein), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Lymphoid Cell Differentiation Pathways. The drugs Anti-Infective Agents and Deoxyglucose have been mentioned in the context of this disorder. Affiliated tissues include lymph node, skin and colon.

Related Diseases for Lymph Node Tuberculosis

Diseases related to Lymph Node Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 410)
# Related Disease Score Top Affiliating Genes
1 tuberculous peritonitis 31.4 IFNG CRP
2 mycobacterium tuberculosis 1 30.9 TNF IFNG CD4
3 extrapulmonary tuberculosis 30.6 SP110 IFNG CRP
4 lymphadenitis 30.4 TNF IFNG CRP CD4
5 mediastinitis 30.2 CRP CD4
6 cat-scratch disease 30.2 CRP CD4
7 cervical adenitis 30.2 CRP CD4
8 parotitis 30.1 CRP CD4
9 posterior scleritis 30.1 TNF CRP
10 hemorrhoid 29.9 TNF CRP
11 cellulitis 29.9 TNF CRP CD4
12 erythema nodosum 29.8 TNF IFNG CRP
13 pleural tuberculosis 29.8 TNF IFNG CD4
14 cryptococcosis 29.8 TNF IFNG CD4
15 abdominal tuberculosis 29.8 TNF IFNG CRP CD4
16 sarcoidosis 1 29.7 TNF IFNG CRP CD4
17 enthesopathy 29.7 TNF CRP
18 multidrug-resistant tuberculosis 29.6 TNF IFNG CD4
19 interstitial lung disease 29.6 TNF IFNG CRP
20 miliary tuberculosis 29.6 TNF IFNG CRP CD4
21 scleritis 29.6 TNF IFNG CRP
22 pleurisy 29.6 TNF IFNG CRP
23 skeletal tuberculosis 29.6 TNF IFNG CRP
24 purpura 29.6 TNF IFNG CRP
25 osteomyelitis 29.6 TNF IFNG CRP
26 otitis media 29.6 TNF IFNG CRP
27 thyroiditis 29.5 TNF IFNG CRP
28 pancytopenia 29.5 IFNG CRP CD4
29 spondylitis 29.4 TNF IFNG CRP
30 temporal arteritis 29.4 TNF IFNG CRP CD4
31 crohn's disease 29.2 TNF IFNG CRP CD4
32 skin disease 29.1 TNF IFNG CRP CD4
33 intestinal tuberculosis 29.0 TNF LTA4H IFNG CRP CD4
34 mesenteric lymphadenitis 10.9
35 pulmonary tuberculosis 10.5
36 lipid pneumonia 10.2 SP110 CRP
37 type 1 diabetes mellitus 23 10.2 TNF CD4
38 epidural abscess 10.2 CRP CD4
39 primary syphilis 10.2 CRP CD4
40 urogenital tuberculosis 10.2 CRP CD4
41 pyomyositis 10.2 CRP CD4
42 splenic abscess 10.2 CRP CD4
43 orbital cellulitis 10.2 CRP CD4
44 acute orbital inflammation 10.2 CRP CD4
45 neuroretinitis 10.2 CRP CD4
46 optic papillitis 10.2 CRP CD4
47 granuloma annulare 10.2 TNF CD4
48 mikulicz disease 10.2 CRP CD4
49 immune deficiency disease 10.2
50 secondary syphilis 10.2 CRP CD4

Graphical network of the top 20 diseases related to Lymph Node Tuberculosis:



Diseases related to Lymph Node Tuberculosis

Symptoms & Phenotypes for Lymph Node Tuberculosis

Symptoms:

12
  • fatigue
  • fever
  • cough
  • weight loss
  • lymphadenopathy
  • night sweats

Drugs & Therapeutics for Lymph Node Tuberculosis

Drugs for Lymph Node Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Infective Agents
2 Deoxyglucose
3 Antiviral Agents
4 Antimetabolites
5 Fluorodeoxyglucose F18

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Diagnosis of Mediastinal Tuberculous Lymphadenopathy by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA) Unknown status NCT01121432
2 Evaluation of Positron Emission Tomography in Extrapulmonary Tuberculosis Completed NCT01613196
3 Role of EBUS-TBNA (Endobronchial Ultrasound Transbronchial Needle Aspiration- in Diagnosing Tuberculosis in Mediastinal and/or Hilar Lymph Nodes Suspended NCT01350674

Search NIH Clinical Center for Lymph Node Tuberculosis

Cochrane evidence based reviews: king's evil

Genetic Tests for Lymph Node Tuberculosis

Anatomical Context for Lymph Node Tuberculosis

The Foundational Model of Anatomy Ontology organs/tissues related to Lymph Node Tuberculosis:

19
Lymph Node

MalaCards organs/tissues related to Lymph Node Tuberculosis:

40
Lymph Node, Skin, Colon, Thyroid, T Cells, Pituitary, Spleen

Publications for Lymph Node Tuberculosis

Articles related to Lymph Node Tuberculosis:

(show top 50) (show all 633)
# Title Authors PMID Year
1
Genetic diversity of the Mycobacterium tuberculosis complex strains from newly diagnosed tuberculosis patients in Northwest Ethiopia reveals a predominance of East-African-Indian and Euro-American lineages. 61
33189940 2021
2
A Case of Nasopharyngeal Tuberculosis with Cervical Lymph Node Tuberculosis Suspected of Cervical Malignant Disease at the First Examination. 61
33572824 2021
3
Xpert MTB/RIF Ultra and Xpert MTB/RIF assays for extrapulmonary tuberculosis and rifampicin resistance in adults. 61
33448348 2021
4
Cervical lymph node tuberculosis and TNF, IL8, IL10, IL12B and IFNG polymorphisms. 61
33582825 2021
5
Outcome of lymph node tuberculosis management with conventional treatment with and without prednisolone. 61
33427091 2021
6
Sternocleidomastoid tumor of infancy-Importance of cytopathological diagnosis and challenges. 61
33369154 2020
7
Chronic massive pericardial effusion: a case report and literature review. 61
33233991 2020
8
The recent trend in mycobacterial strain diversity among extra pulmonary lymph node tuberculosis and their association with drug resistance and the host immunological response in South India. 61
33243148 2020
9
Clinical characteristics and treatment outcome in Tubercular lymphadenitis patients- A prospective observational study. 61
33077055 2020
10
Genotype-Informed Versus Empiric Management Of VirEmia (GIVE MOVE): study protocol of an open-label randomised clinical trial in children and adolescents living with HIV in Lesotho and Tanzania. 61
33076866 2020
11
Lymph Node Tuberculosis With Erythema Nodosum and Bone Nodules on Magnetic Resonance Imaging. 61
32925446 2020
12
Xpert MTB/RIF and Xpert MTB/RIF Ultra assays for active tuberculosis and rifampicin resistance in children. 61
32853411 2020
13
Left-sided portal hypertension caused by peripancreatic lymph node tuberculosis misdiagnosed as pancreatic cancer: a case report and literature review. 61
32811429 2020
14
An unique case report: Unusual presentation of mediastinal lymph node tuberculosis in an adult. 61
32825885 2020
15
Humeral artery aneurysm revealing a rare association between tuberculosis and behçet's disease. 61
32862168 2020
16
Treatment of cervical lymph node tuberculosis: When surgery should be performed? A retrospective cohort study. 61
32489658 2020
17
A rare case of squamous inclusion cyst in cervical lymph node. 61
32613112 2020
18
DOCK8 deficiency with mediastinal lymph node tuberculosis. 61
31016565 2020
19
Prevalence of p-glycoprotein (PGP) expression, function and its effect on efficacy of rifampicin in patients with lymph node tuberculosis. 61
32553308 2020
20
18F-FDG PET-CT Diagnosis of Tuberculosis in Celiac Lymph Nodes. 61
33293851 2020
21
Identification and Treatment of Tuberculosis in Pediatric Recipients of Allogeneic Hematopoietic Stem Cell Transplantation: Case Series and Review of the Literature. 61
32801802 2020
22
Identification of Differentially Expressed Genes Associated with Lymph Node Tuberculosis by the Bioinformatic Analysis Based on a Microarray. 61
31460784 2020
23
Clinical and histological patterns and treatment of pyoderma gangrenosum. 61
32733629 2020
24
Incidence and predictors of extrapulmonary tuberculosis among people living with Human Immunodeficiency Virus in Addis Ababa, Ethiopia: A retrospective cohort study. 61
32374773 2020
25
The use of Gene-Xpert MTB RIF in the diagnosis of extrapulmonary tuberculosis in childhood and adolescence. 61
33027414 2020
26
Epidemiological characteristics and some risk factors of extrapulmonary tuberculosis in Larache, Morocco. 61
33235658 2020
27
Bacteriologically Determined De Novo Tuberculosis during Tumor Necrosis Factor-α Inhibitor Therapy. 61
31434822 2019
28
Evaluation of the Yield of Histopathology in the Diagnosis of Lymph Node Tuberculosis in Morocco, 2017: Cross-Sectional Study. 61
31599732 2019
29
[Study on the sensitivity of multi-slice spiral CT in diagnosis of lymph node metastasis in different lymph node stations of gastric cancer]. 61
31630498 2019
30
[Febrile rhabdomyolysis revealing an abdominal lymph node tuberculosis in an immunocompetent patient]. 61
31548118 2019
31
Fine needle non-aspiration cytology for the diagnosis of cervical lymph node tuberculosis: a single center experience. 61
30017875 2019
32
A politics of the senses: the political role of theKing's-Evil in Richard Wiseman's Severall Chirurgicall Treatises. 61
29970613 2019
33
Comparison of clinical and pathological features of lymph node tuberculosis and histiocytic necrotizing lymphadenitis. 61
32069254 2019
34
Cartridge based nucleic acid amplification test is superior in diagnosing lymphnode tuberculosis. 61
31439187 2019
35
Enhanced Mycobacterial Antigen-Induced Pro-Inflammatory Cytokine Production in Lymph Node Tuberculosis. 61
30994092 2019
36
[One case of tuberculous otitis media with cervical lymph node tuberculosis in child]. 61
31262113 2019
37
Persistent Anemia Combined Increased Serum Sedimentation (ESR) for More Than Two Years Firstly Misdiagnosed as Lymphoma Ultimately Confirmed Systemic Lymph Nodes Tuberculosis by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration Pathology: a Case Report and Literature Review. 61
30868854 2019
38
Comparison of the Microwave-Heated Ziehl-Neelsen Stain and Conventional Ziehl-Neelsen Method in the Detection of Acid-Fast Bacilli in Lymph Node Biopsies. 61
30976331 2019
39
An Overlooked Eighteenth-Century Scrofula Pamphlet: Changing Forms and Changing Readers, 1760-1824. 61
31700650 2019
40
Diagnostic Accuracy of the Xpert MTB/RIF Assay for Lymph Node Tuberculosis: A Systematic Review and Meta-Analysis. 61
31236407 2019
41
The Application of Xpert Mycobacterium tuberculosis/Rifampicin, Quantitative Polymerase Chain Reaction and High Resolution Melting Curve in the Diagnosis of Superficial Lymph Node TB. 61
31333119 2019
42
Hodgkin's lymphoma with marked granulomatous reaction: a diagnostic pitfall. 61
31934112 2019
43
Impact of Mycobacterium tuberculosis complex lineages as a determinant of disease phenotypes from an immigrant rich moderate tuberculosis burden country. 61
30587190 2018
44
Immune activation and regulatory T cells in Mycobacterium tuberculosis infected lymph nodes. 61
30409122 2018
45
High IL-6 and VEGF-A levels correlate with delayed wound healing in cervical lymph node tuberculosis patients. 61
30236193 2018
46
[Culture proven extra pulmonary tuberculosis: drug susceptibility and genetic profile analysis]. 61
30479231 2018
47
Pituitary tuberculosis presented with pituitary coma. 61
30430535 2018
48
Man with bilateral inguinal lymphadenopathy. 61
30030235 2018
49
Endothelial lineage-specific interaction of Mycobacterium tuberculosis with the blood and lymphatic systems. 61
30029892 2018
50
Vacuum-assisted closure therapy of paradoxical reaction in tuberculous lymphadenopathy caused by Mycobacterium africanum. 61
29330673 2018

Variations for Lymph Node Tuberculosis

Expression for Lymph Node Tuberculosis

Search GEO for disease gene expression data for Lymph Node Tuberculosis.

Pathways for Lymph Node Tuberculosis

GO Terms for Lymph Node Tuberculosis

Biological processes related to Lymph Node Tuberculosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.65 TNF IFNG IFI44L ENDOU CD4
2 positive regulation of osteoclast differentiation GO:0045672 9.49 TNF IFNG
3 macrophage differentiation GO:0030225 9.48 IFNG CD4
4 positive regulation of amyloid-beta formation GO:1902004 9.46 TNF IFNG
5 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.43 TNF IFNG
6 astrocyte activation GO:0048143 9.4 TNF IFNG
7 negative regulation of amyloid-beta clearance GO:1900222 9.37 TNF IFNG
8 negative regulation of lipid storage GO:0010888 9.32 TNF CRP
9 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 TNF IFNG
10 positive regulation of vitamin D biosynthetic process GO:0060557 8.96 TNF IFNG
11 positive regulation of nitrogen compound metabolic process GO:0051173 8.62 TNF IFNG

Sources for Lymph Node Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....