MCID: LYM010
MIFTS: 41

Lymph Node Tuberculosis

Categories: Immune diseases, Infectious diseases

Aliases & Classifications for Lymph Node Tuberculosis

MalaCards integrated aliases for Lymph Node Tuberculosis:

Name: Lymph Node Tuberculosis 12 15 17 71
King's Evil 12 43 71
Scrofula 12 71
Tuberculous Lymphadenopathy 12
Tuberculosis, Lymph Node 43
Tuberculous Adenitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4889
NCIt 49 C26896
SNOMED-CT 67 10893003
ICD10 32 A18.2
UMLS 71 C0036467 C0041316 C0242830

Summaries for Lymph Node Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that is located in lymph node, and has symptom lymphadenopathy, has symptom fever, has symptom weight loss, has symptom fatigue, has symptom night sweats and has symptom cough.

MalaCards based summary : Lymph Node Tuberculosis, also known as king's evil, is related to lymphadenitis and extrapulmonary tuberculosis, and has symptoms including fatigue, fever and weight loss. An important gene associated with Lymph Node Tuberculosis is SP110 (SP110 Nuclear Body Protein), and among its related pathways/superpathways are Hematopoietic Stem Cells and Lineage-specific Markers and IL27-mediated signaling events. The drugs Fluorodeoxyglucose F18 and Antiviral Agents have been mentioned in the context of this disorder. Affiliated tissues include lymph node, lung and testes.

Related Diseases for Lymph Node Tuberculosis

Diseases related to Lymph Node Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 254)
# Related Disease Score Top Affiliating Genes
1 lymphadenitis 30.7 TNF IFNG CD4
2 extrapulmonary tuberculosis 30.3 TNF SP110 IFNG CD4
3 parotitis 30.3 L3MBTL1 CD4
4 abdominal tuberculosis 30.2 TNF IFNG CD4
5 multidrug-resistant tuberculosis 30.0 TNF IFNG CD4
6 miliary tuberculosis 30.0 TNF IFNG CD4
7 sarcoidosis 1 30.0 TNF IFNG CD4
8 pleural tuberculosis 29.8 TNF IFNG CD4
9 cryptococcosis 29.8 TNF IFNG CD4
10 syphilis 29.8 TNF IFNG CD4
11 cellulitis 29.8 TNF IFNG CD4
12 temporal arteritis 29.8 TNF IFNG CD4
13 intestinal tuberculosis 29.1 TNF LTA4H IFNG CD4
14 mesenteric lymphadenitis 11.2
15 tuberculous peritonitis 11.2
16 mycobacterium tuberculosis 1 10.9
17 pulmonary tuberculosis 10.5
18 gastroduodenitis 10.4 ZBTB32 CD4
19 ocular tuberculosis 10.3 IFNG CD4
20 panophthalmitis 10.3 IFNG CD4
21 parotid disease 10.3 L3MBTL1 CD4
22 chronic graft versus host disease 10.3 IFNG CD4
23 pericardial tuberculosis 10.3 IFNG CD4
24 purulent endophthalmitis 10.3 IFNG CD4
25 latent syphilis 10.3 IFNG CD4
26 penicilliosis 10.3 IFNG CD4
27 nickel allergic contact dermatitis 10.3 IFNG CD4
28 diabetes mellitus, insulin-dependent, 23 10.2 TNF CD4
29 rheumatoid arthritis interstitial lung disease 10.2 TNF CD4
30 duodenitis 10.2 TNF CD4
31 skin sarcoidosis 10.2 TNF CD4
32 aspiration pneumonitis 10.2 TNF SP110
33 metal allergy 10.2 TNF CD4
34 cerebritis 10.2 TNF CD4
35 granulomatous hepatitis 10.2 TNF CD4
36 sporotrichosis 10.2 IFNG CD4
37 granuloma annulare 10.2 TNF CD4
38 mononeuritis of upper limb and mononeuritis multiplex 10.2 TNF CD4
39 mononeuritis multiplex 10.2 TNF CD4
40 granulomatous dermatitis 10.2 TNF CD4
41 superficial basal cell carcinoma 10.2 TNF CD4
42 aortitis 10.2 TNF CD4
43 neurosarcoidosis 10.2 TNF CD4
44 hypopyon 10.2 TNF CD4
45 pneumonic tularemia 10.2 TNF CD4
46 farmer's lung 10.2 TNF CD4
47 blastomycosis 10.2 TNF CD4
48 staphylococcal toxic shock syndrome 10.2 TNF IFNG
49 autoimmune myocarditis 10.2 TNF IFNG
50 pneumonic plague 10.2 TNF CD4

Graphical network of the top 20 diseases related to Lymph Node Tuberculosis:



Diseases related to Lymph Node Tuberculosis

Symptoms & Phenotypes for Lymph Node Tuberculosis

Symptoms:

12
  • fatigue
  • fever
  • weight loss
  • cough
  • lymphadenopathy
  • night sweats

Drugs & Therapeutics for Lymph Node Tuberculosis

Drugs for Lymph Node Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fluorodeoxyglucose F18
2 Antiviral Agents
3 Deoxyglucose
4 Antimetabolites
5 Anti-Infective Agents
6 Fluorides

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Diagnosis of Mediastinal Tuberculous Lymphadenopathy by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA) Unknown status NCT01121432
2 Significance of Endoscopic Ultrasonography Guided Transbronchial Lymph Node Biopsy (TBNA) and Ultrasound Elastography in Lymph Node Unknown status NCT03391557
3 Evaluation of Positron Emission Tomography in Extrapulmonary Tuberculosis Completed NCT01613196
4 Value of EBUS-TBNA for Mediastinal Lymph Nodes in Non-small Cell Lung Cancer in a Tuberculosis-endemic Country Completed NCT01156623
5 Role of EBUS-TBNA (Endobronchial Ultrasound Transbronchial Needle Aspiration- in Diagnosing Tuberculosis in Mediastinal and/or Hilar Lymph Nodes Suspended NCT01350674

Search NIH Clinical Center for Lymph Node Tuberculosis

Cochrane evidence based reviews: king's evil

Genetic Tests for Lymph Node Tuberculosis

Anatomical Context for Lymph Node Tuberculosis

The Foundational Model of Anatomy Ontology organs/tissues related to Lymph Node Tuberculosis:

19
Lymph Node

MalaCards organs/tissues related to Lymph Node Tuberculosis:

40
Lymph Node, Lung, Testes, Skin, Breast, T Cells, Tonsil

Publications for Lymph Node Tuberculosis

Articles related to Lymph Node Tuberculosis:

(show top 50) (show all 607)
# Title Authors PMID Year
1
Treatment of cervical lymph node tuberculosis: When surgery should be performed? A retrospective cohort study. 61
32489658 2020
2
DOCK8 deficiency with mediastinal lymph node tuberculosis. 61
31016565 2020
3
Prevalence of p-glycoprotein (PGP) expression, function and its effect on efficacy of rifampicin in patients with lymph node tuberculosis. 61
32553308 2020
4
Identification of Differentially Expressed Genes Associated with Lymph Node Tuberculosis by the Bioinformatic Analysis Based on a Microarray. 61
31460784 2020
5
Incidence and predictors of extrapulmonary tuberculosis among people living with Human Immunodeficiency Virus in Addis Ababa, Ethiopia: A retrospective cohort study. 61
32374773 2020
6
Bacteriologically Determined De Novo Tuberculosis during Tumor Necrosis Factor-α Inhibitor Therapy. 61
31434822 2019
7
Evaluation of the Yield of Histopathology in the Diagnosis of Lymph Node Tuberculosis in Morocco, 2017: Cross-Sectional Study. 61
31599732 2019
8
[Study on the sensitivity of multi-slice spiral CT in diagnosis of lymph node metastasis in different lymph node stations of gastric cancer]. 61
31630498 2019
9
[Febrile rhabdomyolysis revealing an abdominal lymph node tuberculosis in an immunocompetent patient]. 61
31548118 2019
10
Fine needle non-aspiration cytology for the diagnosis of cervical lymph node tuberculosis: a single center experience. 61
30017875 2019
11
A politics of the senses: the political role of theKing's-Evil in Richard Wiseman's Severall Chirurgicall Treatises. 61
29970613 2019
12
Comparison of clinical and pathological features of lymph node tuberculosis and histiocytic necrotizing lymphadenitis. 61
32069254 2019
13
Cartridge based nucleic acid amplification test is superior in diagnosing lymphnode tuberculosis. 61
31439187 2019
14
Enhanced Mycobacterial Antigen-Induced Pro-Inflammatory Cytokine Production in Lymph Node Tuberculosis. 61
30994092 2019
15
[One case of tuberculous otitis media with cervical lymph node tuberculosis in child]. 61
31262113 2019
16
Persistent Anemia Combined Increased Serum Sedimentation (ESR) for More Than Two Years Firstly Misdiagnosed as Lymphoma Ultimately Confirmed Systemic Lymph Nodes Tuberculosis by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration Pathology: a Case Report and Literature Review. 61
30868854 2019
17
Comparison of the Microwave-Heated Ziehl-Neelsen Stain and Conventional Ziehl-Neelsen Method in the Detection of Acid-Fast Bacilli in Lymph Node Biopsies. 61
30976331 2019
18
An Overlooked Eighteenth-Century Scrofula Pamphlet: Changing Forms and Changing Readers, 1760-1824. 61
31700650 2019
19
The Application of Xpert Mycobacterium tuberculosis/Rifampicin, Quantitative Polymerase Chain Reaction and High Resolution Melting Curve in the Diagnosis of Superficial Lymph Node TB. 61
31333119 2019
20
Diagnostic Accuracy of the Xpert MTB/RIF Assay for Lymph Node Tuberculosis: A Systematic Review and Meta-Analysis. 61
31236407 2019
21
Hodgkin's lymphoma with marked granulomatous reaction: a diagnostic pitfall. 61
31934112 2019
22
Impact of Mycobacterium tuberculosis complex lineages as a determinant of disease phenotypes from an immigrant rich moderate tuberculosis burden country. 61
30587190 2018
23
Immune activation and regulatory T cells in Mycobacterium tuberculosis infected lymph nodes. 61
30409122 2018
24
High IL-6 and VEGF-A levels correlate with delayed wound healing in cervical lymph node tuberculosis patients. 61
30236193 2018
25
[Culture proven extra pulmonary tuberculosis: drug susceptibility and genetic profile analysis]. 61
30479231 2018
26
Pituitary tuberculosis presented with pituitary coma. 61
30430535 2018
27
Man with bilateral inguinal lymphadenopathy. 61
30030235 2018
28
Endothelial lineage-specific interaction of Mycobacterium tuberculosis with the blood and lymphatic systems. 61
30029892 2018
29
Vacuum-assisted closure therapy of paradoxical reaction in tuberculous lymphadenopathy caused by Mycobacterium africanum. 61
29330673 2018
30
Bilateral central retinal artery occlusion as presenting manifestation of human immunodeficiency virus infection. 61
29480272 2018
31
Pathology of lymph node tuberculosis in Yaounde: diagnostic agreement based on the Kappa coefficient. 61
30455787 2018
32
Clinical efficacy of short-course chemotherapy combined with topical injection therapy in treatment of superficial lymph node tuberculosis. 61
29299116 2017
33
Loss of vision and hearing in a case of cervical lymph node tuberculosis: A rare paradoxical reaction. 61
29099011 2017
34
[Endobronchial Ultrasound (EBUS) - an Update 2017]. 61
29139101 2017
35
[Diagnosis value with Xpert Mtb/RIF assay for cervical tuberculous lymphadenitis]. 61
29798226 2017
36
Pattern and predictors of paradoxical response in patients with peripheral lymph node tuberculosis. 61
29135395 2017
37
Primary peripancreatic lymph node tuberculosis as a differential diagnosis of pancreatic neoplasia. 61
28506074 2017
38
Clinical usefulness of 18F-FDG PET/CT for initial staging and assessment of treatment efficacy in patients with lymph node tuberculosis. 61
28426991 2017
39
Lymph node tuberculosis mimicking malignancy on 18F-FDG PET/CT in two patients: A case report. 61
28587415 2017
40
Spontaneous chylothorax revealing a mediastinal and abdominal lymph node tuberculosis. 61
28410698 2017
41
The history of tuberculosis: from the first historical records to the isolation of Koch's bacillus. 61
28515626 2017
42
Tuberculosis After Renal Transplant. 61
28260468 2017
43
Miliary tuberculosis infection during hepatitis C treatment with sofosbuvir and ledipasvir plus ribavirin. 61
28217253 2017
44
Bronchopleural and pleurocutaneous fistula in HIV patient with pulmonary tuberculosis. 61
28725561 2017
45
Tuberculosis infection in children with proteinuria/nephrotic syndrome. 61
29204099 2017
46
Paradoxical reaction associated with cervical lymph node tuberculosis: predictive factors and therapeutic management. 61
27810522 2017
47
[Recurrent fever, hepatosplenomegaly and eosinophilia in a boy]. 61
27817782 2016
48
Linezolid for Infants and Toddlers With Disseminated Tuberculosis: First Steps. 61
27742638 2016
49
A case series and review of Poncet's disease, and the utility of current diagnostic criteria. 61
26354099 2016
50
[A CASE OF LYMPH NODE TUBERCULOSIS ASSOCIATED WITH A FLUID-FILLED MASS IN THE THORACIC WALL DUE TO A PARADOXICAL RESPONSE TO THERAPY]. 61
30646456 2016

Variations for Lymph Node Tuberculosis

Expression for Lymph Node Tuberculosis

Search GEO for disease gene expression data for Lymph Node Tuberculosis.

Pathways for Lymph Node Tuberculosis

Pathways related to Lymph Node Tuberculosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.61 TNF IFNG CD4
2
Show member pathways
11.52 TNF IFNG CD4
3 11.34 TNF IFNG CD4
4 11.2 TNF IFNG CD4
5 10.81 TNF IFNG CES3
6 10.26 TNF IFNG CD4

GO Terms for Lymph Node Tuberculosis

Biological processes related to Lymph Node Tuberculosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of osteoclast differentiation GO:0045672 9.49 TNF IFNG
2 macrophage differentiation GO:0030225 9.48 IFNG CD4
3 positive regulation of amyloid-beta formation GO:1902004 9.46 TNF IFNG
4 astrocyte activation GO:0048143 9.43 TNF IFNG
5 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.4 TNF IFNG
6 positive regulation of chemokine biosynthetic process GO:0045080 9.37 TNF IFNG
7 negative regulation of amyloid-beta clearance GO:1900222 9.32 TNF IFNG
8 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.26 TNF IFNG
9 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 TNF IFNG
10 positive regulation of vitamin D biosynthetic process GO:0060557 8.96 TNF IFNG
11 positive regulation of nitrogen compound metabolic process GO:0051173 8.62 TNF IFNG

Molecular functions related to Lymph Node Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.02 ZBTB32 TIMM10 LTA4H L3MBTL1 CD4

Sources for Lymph Node Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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