MCID: LYM010
MIFTS: 40

Lymph Node Tuberculosis

Categories: Immune diseases, Infectious diseases

Aliases & Classifications for Lymph Node Tuberculosis

MalaCards integrated aliases for Lymph Node Tuberculosis:

Name: Lymph Node Tuberculosis 12 15 73
King's Evil 12 44 73
Scrofula 12 73
Tuberculous Lymphadenopathy 12
Tuberculosis, Lymph Node 44
Tuberculous Adenitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4889
ICD10 33 A18.2
NCIt 50 C26896
SNOMED-CT 68 10893003

Summaries for Lymph Node Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that is located in lymph node, and has symptom lymphadenopathy, has symptom fever, has symptom weight loss, has symptom fatigue, has symptom night sweats and has symptom cough.

MalaCards based summary : Lymph Node Tuberculosis, also known as king's evil, is related to lymphadenitis and extrapulmonary tuberculosis, and has symptoms including fever, fatigue and weight loss. An important gene associated with Lymph Node Tuberculosis is SP110 (SP110 Nuclear Body Protein). The drugs Ethanol and Formaldehyde have been mentioned in the context of this disorder. Affiliated tissues include lymph node, lung and colon, and related phenotypes are craniofacial and respiratory system

Related Diseases for Lymph Node Tuberculosis

Diseases related to Lymph Node Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 lymphadenitis 11.4
2 extrapulmonary tuberculosis 11.1
3 mesenteric lymphadenitis 11.1
4 tuberculous peritonitis 11.1
5 cervical adenitis 10.3
6 pulmonary tuberculosis 10.1
7 langerhans cell histiocytosis 10.0
8 dyspepsia 10.0
9 histiocytosis 10.0
10 mycobacterium tuberculosis 1 10.0
11 myelodysplastic syndrome 10.0
12 goiter 9.9
13 nodular goiter 9.9
14 cholestasis 9.9
15 extrahepatic cholestasis 9.9
16 skeletal tuberculosis 9.9
17 subacute thyroiditis 9.9
18 thyroiditis 9.9
19 epididymitis 9.9
20 breast metaplastic carcinoma 9.9 FEZF1 FEZF2
21 eyelid carcinoma 9.9 FEZF1 FEZF2
22 acute laryngitis 9.9 FEZF1 FEZF2
23 uterine inversion 9.9 FEZF1 FEZF2
24 bladder cancer 9.9
25 breast cancer 9.9
26 rheumatoid arthritis 9.9
27 arthritis 9.9
28 thrombocytopenia 9.9
29 lymphoma 9.9
30 osteomyelitis 9.9
31 cat-scratch disease 9.9
32 thrombocytopenia due to platelet alloimmunization 9.9
33 melanoma 9.9
34 interstitial lung disease 9.9
35 purpura 9.9
36 pyoderma 9.9
37 human immunodeficiency virus infectious disease 9.9
38 pneumonia 9.9
39 inflammatory breast carcinoma 9.9
40 lung disease 9.9
41 pyoderma gangrenosum 9.9
42 miliary tuberculosis 9.9
43 lung cancer 9.9
44 phaeohyphomycosis 9.8 FEZF1 FEZF2
45 leukemia 9.8
46 abdominal tuberculosis 9.8
47 natural killer cell leukemia 9.8
48 neurodermatitis 9.8 FEZF1 FEZF2

Graphical network of the top 20 diseases related to Lymph Node Tuberculosis:



Diseases related to Lymph Node Tuberculosis

Symptoms & Phenotypes for Lymph Node Tuberculosis

Symptoms:

12
  • fever
  • fatigue
  • weight loss
  • cough
  • lymphadenopathy
  • night sweats

MGI Mouse Phenotypes related to Lymph Node Tuberculosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.26 FBLN5 FEZF1 FEZF2 THRA
2 respiratory system MP:0005388 8.92 FBLN5 FEZF1 FEZF2 PTBP2

Drugs & Therapeutics for Lymph Node Tuberculosis

Drugs for Lymph Node Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Not Applicable 64-17-5 702
2
Formaldehyde Approved, Vet_approved Not Applicable 50-00-0 712
3 Disinfectants Not Applicable
4 Anti-Infective Agents Not Applicable
5 Deoxyglucose Not Applicable
6 Fluorodeoxyglucose F18 Not Applicable
7 Antimetabolites Not Applicable
8 Antiviral Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Diagnosis of Mediastinal Tuberculous Lymphadenopathy by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA) Unknown status NCT01121432
2 Diagnostic Accuracy of Polymerase Chain Reaction for Mycobacterium Tuberculosis Using EBUS-TBNA Samples Unknown status NCT02497079 Not Applicable
3 Positron Emission Tomography in Extrapulmonary Tuberculosis Completed NCT01613196 Not Applicable
4 Role of EBUS-TBNA in Diagnosing TB in Mediastinal/Hilar Lymph Nodes Suspended NCT01350674 Not Applicable

Search NIH Clinical Center for Lymph Node Tuberculosis

Cochrane evidence based reviews: king's evil

Genetic Tests for Lymph Node Tuberculosis

Anatomical Context for Lymph Node Tuberculosis

MalaCards organs/tissues related to Lymph Node Tuberculosis:

41
Lymph Node, Lung, Colon, Testes, Tonsil, Cortex, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Lymph Node Tuberculosis:

19
Lymph Node

Publications for Lymph Node Tuberculosis

Articles related to Lymph Node Tuberculosis:

(show top 50) (show all 110)
# Title Authors Year
1
Fine needle non-aspiration cytology for the diagnosis of cervical lymph node tuberculosis: a single center experience. ( 30017875 )
2018
2
High IL-6 and VEGF-A levels correlate with delayed wound healing in cervical lymph node tuberculosis patients. ( 30236193 )
2018
3
Pathology of lymph node tuberculosis in Yaounde: diagnostic agreement based on the Kappa coefficient. ( 30455787 )
2018
4
A politics of the senses: the political role of the King's-Evil in Richard Wiseman's Severall Chirurgicall Treatises. ( 29970613 )
2018
5
Clinical usefulness of (18)F-FDG PET/CT for initial staging and assessment of treatment efficacy in patients with lymph node tuberculosis. ( 28426991 )
2017
6
Clinical efficacy of short-course chemotherapy combined with topical injection therapy in treatment of superficial lymph node tuberculosis. ( 29299116 )
2017
7
Primary peripancreatic lymph node tuberculosis as a differential diagnosis of pancreatic neoplasia. ( 28506074 )
2017
8
Loss of vision and hearing in a case of cervical lymph node tuberculosis: A rare paradoxical reaction. ( 29099011 )
2017
9
Lymph node tuberculosis mimicking malignancy on (18)F-FDG PET/CT in two patients: A case report. ( 28587415 )
2017
10
Spontaneous chylothorax revealing a mediastinal and abdominal lymph node tuberculosis. ( 28410698 )
2017
11
Paradoxical reaction associated with cervical lymph node tuberculosis: predictive factors and therapeutic management. ( 27810522 )
2017
12
Pattern and predictors of paradoxical response in patients with peripheral lymph node tuberculosis. ( 29135395 )
2017
13
Diagnostic performance of interferon-I^ release assay for lymph node tuberculosis. ( 26971638 )
2016
14
Add-on prednisolone in the management of cervical lymph node tuberculosis. ( 27451818 )
2016
15
Lymph node tuberculosis after melanoma treatment - sometimes the patient is lucky. ( 28174808 )
2016
16
A Case Report: Systemic Lymph Node Tuberculosis Mimicking Lymphoma on 18F-FDG PET/CT. ( 26945389 )
2016
17
The King's Evil and the Royal Touch: the medical history of scrofula. ( 27155172 )
2016
18
Lymph node tuberculosis after allogeneic haematopoietic stem cell transplantation: an atypical presentation of an uncommon complication. ( 26015804 )
2015
19
Delayed diagnosis of lymph node tuberculosis: time-honored importance of a thorough clinical examination, Cameroon. ( 26405474 )
2015
20
MICROSCOPIC-OBSERVATION DRUG-SUSCEPTIBILITY (MODS) FOR RAPID DIAGNOSIS OF LYMPH NODE TUBERCULOSIS AND DETECTION OF DRUG RESISTANCE. ( 26511739 )
2015
21
Diagnosis of lymph node tuberculosis using the GeneXpert MTB/RIF in Tunisia. ( 26964807 )
2015
22
Epidemiology of Peripheral Lymph Node Tuberculosis and Genotyping of M. tuberculosis Strains: A Case-Control Study. ( 26177546 )
2015
23
Axillary lymph node tuberculosis masquerading as inflammatory breast carcinoma in an immune-compromised patient. ( 25681261 )
2015
24
Lymph node tuberculosis - an attempt of clinico-morphological study and review of the literature. ( 25178325 )
2014
25
Immune thrombocytopenia (ITP): a rare association of lymph node tuberculosis. ( 25327103 )
2014
26
A late presentation of isolated lymph node tuberculosis postintravesical BCG therapy for superficial bladder cancer: a novel case. ( 24792024 )
2014
27
Progenitor "Mycobacterium canettii" Clone Responsible for Lymph Node Tuberculosis Epidemic, Djibouti. ( 24378119 )
2014
28
Progenitor a89Mycobacterium canettiia89 clone responsible for lymph node tuberculosis epidemic, Djibouti. ( 24520560 )
2014
29
Cat scratch disease and lymph node tuberculosis in a colon patient with cancer. ( 24334464 )
2013
30
Systemic lymph node tuberculosis presenting with an aseptic psoas abscess caused by a paradoxical reaction after nine months of antituberculosis treatment: a case report. ( 23497500 )
2013
31
Interstitial lung disease and profound hypoxaemia in a severely-malnourished child with very severe pneumonia and potential lymph-node tuberculosis: an uncommon but serious co-morbidity. ( 23617214 )
2013
32
Diagnostic usefulness of a T-cell-based assay in patients with miliary tuberculosis compared with those with lymph node tuberculosis. ( 23051762 )
2013
33
Diagnostic accuracy and effectiveness of the Xpert MTB/RIF assay for the diagnosis of HIV-associated lymph node tuberculosis. ( 23660698 )
2013
34
Pancreatic head region lymph node tuberculosis mimicking pancreatic solid pseudopapillary tumor. ( 23489813 )
2013
35
Risk factors for prolonged treatment of lymph node tuberculosis. ( 22230257 )
2012
36
Isolated axillary lymph node tuberculosis in ultrasonography. A case report. ( 26674808 )
2012
37
Scrofula, the king's evil. ( 22371516 )
2012
38
Management of peripheral lymph node tuberculosis in routine practice: an unselected 10-year cohort. ( 21333106 )
2011
39
Assessment of lymph node tuberculosis in two provinces in Turkey. ( 21788708 )
2011
40
Sweet's syndrome in a patient with rheumatoid arthritis, SjAPgren's syndrome and lymph node tuberculosis. ( 22714601 )
2011
41
Genetic association study suggests a role for SP110 variants in lymph node tuberculosis but not pulmonary tuberculosis in north Indians. ( 21536091 )
2011
42
Lymph node tuberculosis. Time for a culture change? ( 20388678 )
2010
43
Post-therapy paradoxical response in immunocompetent patients with lymph node tuberculosis. ( 20831881 )
2010
44
Lymph node tuberculosis in patients from regions with varying burdens of tuberculosis and human immunodeficiency virus (HIV) infection. ( 20646895 )
2010
45
Lymph node tuberculosis and paradoxical evolution. ( 20122063 )
2010
46
Epidemiological, therapeutic and evolutionary profiles in patients with lymph node tuberculosis. ( 21341113 )
2010
47
Treatment for lymph node tuberculosis. ( 20219818 )
2010
48
A historical vignette (18). The King's Evil: scrofula, physicians and the Royal Touch. ( 20681372 )
2010
49
Paradoxical responses in non-HIV-infected patients with peripheral lymph node tuberculosis. ( 19535147 )
2009
50
Intraparotid lymph node tuberculosis. ( 18500020 )
2008

Variations for Lymph Node Tuberculosis

Expression for Lymph Node Tuberculosis

Search GEO for disease gene expression data for Lymph Node Tuberculosis.

Pathways for Lymph Node Tuberculosis

GO Terms for Lymph Node Tuberculosis

Biological processes related to Lymph Node Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of neuron differentiation GO:0045666 9.37 FEZF1 FEZF2
2 forebrain development GO:0030900 9.32 FEZF1 FEZF2
3 regulation of neurogenesis GO:0050767 9.26 FEZF1 FEZF2
4 telencephalon development GO:0021537 9.16 FEZF1 FEZF2
5 cell dedifferentiation GO:0043697 8.96 FEZF1 FEZF2
6 forebrain anterior/posterior pattern specification GO:0021797 8.62 FEZF1 FEZF2

Molecular functions related to Lymph Node Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.46 FEZF1 FEZF2 SP110 THRA
2 sequence-specific DNA binding GO:0043565 9.43 FEZF1 FEZF2 THRA
3 chromatin DNA binding GO:0031490 8.96 FEZF2 THRA
4 transcription regulatory region DNA binding GO:0044212 8.8 FEZF1 FEZF2 THRA

Sources for Lymph Node Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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