MCID: LYM010
MIFTS: 41

Lymph Node Tuberculosis

Categories: Immune diseases, Infectious diseases

Aliases & Classifications for Lymph Node Tuberculosis

MalaCards integrated aliases for Lymph Node Tuberculosis:

Name: Lymph Node Tuberculosis 12 15 17 74
King's Evil 12 45 74
Scrofula 12 74
Tuberculous Lymphadenopathy 12
Tuberculosis, Lymph Node 45
Tuberculous Adenitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4889
NCIt 51 C26896
SNOMED-CT 69 10893003
ICD10 34 A18.2

Summaries for Lymph Node Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that is located in lymph node, and has symptom lymphadenopathy, has symptom fever, has symptom weight loss, has symptom fatigue, has symptom night sweats and has symptom cough.

MalaCards based summary : Lymph Node Tuberculosis, also known as king's evil, is related to extrapulmonary tuberculosis and mesenteric lymphadenitis, and has symptoms including fever, fatigue and weight loss. An important gene associated with Lymph Node Tuberculosis is SP110 (SP110 Nuclear Body Protein). The drugs Formaldehyde and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include lymph node, breast and lung, and related phenotypes are cellular and respiratory system

Related Diseases for Lymph Node Tuberculosis

Diseases related to Lymph Node Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 extrapulmonary tuberculosis 11.1
2 mesenteric lymphadenitis 11.1
3 tuberculous peritonitis 11.1
4 lymphadenitis 10.5
5 cervical adenitis 10.3
6 mycobacterium tuberculosis 1 10.2
7 pulmonary tuberculosis 10.1
8 langerhans cell histiocytosis 10.0
9 choreatic disease 10.0
10 gout 10.0
11 enthesopathy 10.0
12 dyspepsia 10.0
13 histiocytosis 10.0
14 breast cancer 10.0
15 lymphoma 10.0
16 myelodysplastic syndrome 10.0
17 breast metaplastic carcinoma 10.0 FEZF1 FEZF2
18 goiter 10.0
19 nodular goiter 10.0
20 cholestasis 10.0
21 extrahepatic cholestasis 10.0
22 skeletal tuberculosis 10.0
23 subacute thyroiditis 10.0
24 thyroiditis 10.0
25 eyelid carcinoma 10.0 FEZF1 FEZF2
26 acute laryngitis 9.9 FEZF1 FEZF2
27 uterine inversion 9.9 FEZF1 FEZF2
28 bladder cancer 9.9
29 rheumatoid arthritis 9.9
30 sjogren syndrome 9.9
31 deficiency anemia 9.9
32 arthritis 9.9
33 thrombocytopenia 9.9
34 osteomyelitis 9.9
35 cat-scratch disease 9.9
36 obstructive jaundice 9.9
37 thrombocytopenia due to platelet alloimmunization 9.9
38 melanoma 9.9
39 interstitial lung disease 9.9
40 purpura 9.9
41 pyoderma 9.9
42 human immunodeficiency virus infectious disease 9.9
43 pneumonia 9.9
44 inflammatory breast carcinoma 9.9
45 lung disease 9.9
46 pyoderma gangrenosum 9.9
47 miliary tuberculosis 9.9
48 cytokine deficiency 9.9
49 lymphangiectasis 9.9
50 phaeohyphomycosis 9.8 FEZF1 FEZF2

Graphical network of the top 20 diseases related to Lymph Node Tuberculosis:



Diseases related to Lymph Node Tuberculosis

Symptoms & Phenotypes for Lymph Node Tuberculosis

Symptoms:

12
  • fever
  • fatigue
  • weight loss
  • cough
  • lymphadenopathy
  • night sweats

MGI Mouse Phenotypes related to Lymph Node Tuberculosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.55 DOCK8 FBLN5 FEZF1 FEZF2 PTBP2
2 respiratory system MP:0005388 9.26 FBLN5 FEZF1 FEZF2 PTBP2
3 taste/olfaction MP:0005394 8.62 FEZF1 FEZF2

Drugs & Therapeutics for Lymph Node Tuberculosis

Drugs for Lymph Node Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Formaldehyde Approved, Vet_approved Not Applicable 50-00-0 712
2
Ethanol Approved Not Applicable 64-17-5 702
3 Disinfectants Not Applicable
4 Anti-Infective Agents Not Applicable
5 Fluorodeoxyglucose F18 Not Applicable
6 Deoxyglucose Not Applicable
7 Antiviral Agents Not Applicable
8 Antimetabolites Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Diagnosis of Mediastinal Tuberculous Lymphadenopathy by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA) Unknown status NCT01121432
2 Diagnostic Accuracy of Polymerase Chain Reaction for Mycobacterium Tuberculosis Using EBUS-TBNA Samples Unknown status NCT02497079 Not Applicable
3 Positron Emission Tomography in Extrapulmonary Tuberculosis Completed NCT01613196 Not Applicable
4 Role of EBUS-TBNA in Diagnosing TB in Mediastinal/Hilar Lymph Nodes Suspended NCT01350674 Not Applicable

Search NIH Clinical Center for Lymph Node Tuberculosis

Cochrane evidence based reviews: king's evil

Genetic Tests for Lymph Node Tuberculosis

Anatomical Context for Lymph Node Tuberculosis

MalaCards organs/tissues related to Lymph Node Tuberculosis:

42
Lymph Node, Breast, Lung, Thyroid, Colon, Testes, Cortex

The Foundational Model of Anatomy Ontology organs/tissues related to Lymph Node Tuberculosis:

20
Lymph Node

Publications for Lymph Node Tuberculosis

Articles related to Lymph Node Tuberculosis:

(show top 50) (show all 112)
# Title Authors Year
1
Enhanced Mycobacterial Antigen-Induced Pro-Inflammatory Cytokine Production in Lymph Node Tuberculosis. ( 30994092 )
2019
2
DOCK8 deficiency with mediastinal lymph node tuberculosis. ( 31016565 )
2019
3
Fine needle non-aspiration cytology for the diagnosis of cervical lymph node tuberculosis: a single center experience. ( 30017875 )
2018
4
High IL-6 and VEGF-A levels correlate with delayed wound healing in cervical lymph node tuberculosis patients. ( 30236193 )
2018
5
Pathology of lymph node tuberculosis in Yaounde: diagnostic agreement based on the Kappa coefficient. ( 30455787 )
2018
6
A politics of the senses: the political role of the King's-Evil in Richard Wiseman's Severall Chirurgicall Treatises. ( 29970613 )
2018
7
Paradoxical reaction associated with cervical lymph node tuberculosis: predictive factors and therapeutic management. ( 27810522 )
2017
8
Spontaneous chylothorax revealing a mediastinal and abdominal lymph node tuberculosis. ( 28410698 )
2017
9
Clinical usefulness of 18F-FDG PET/CT for initial staging and assessment of treatment efficacy in patients with lymph node tuberculosis. ( 28426991 )
2017
10
Primary peripancreatic lymph node tuberculosis as a differential diagnosis of pancreatic neoplasia. ( 28506074 )
2017
11
Lymph node tuberculosis mimicking malignancy on 18F-FDG PET/CT in two patients: A case report. ( 28587415 )
2017
12
Loss of vision and hearing in a case of cervical lymph node tuberculosis: A rare paradoxical reaction. ( 29099011 )
2017
13
Pattern and predictors of paradoxical response in patients with peripheral lymph node tuberculosis. ( 29135395 )
2017
14
Clinical efficacy of short-course chemotherapy combined with topical injection therapy in treatment of superficial lymph node tuberculosis. ( 29299116 )
2017
15
Axillary lymph node tuberculosis masquerading as inflammatory breast carcinoma in an immune-compromised patient. ( 25681261 )
2016
16
Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance. ( 26511739 )
2016
17
A Case Report: Systemic Lymph Node Tuberculosis Mimicking Lymphoma on 18F-FDG PET/CT. ( 26945389 )
2016
18
Diagnostic performance of interferon-γ release assay for lymph node tuberculosis. ( 26971638 )
2016
19
Add-on prednisolone in the management of cervical lymph node tuberculosis. ( 27451818 )
2016
20
Lymph node tuberculosis after melanoma treatment - sometimes the patient is lucky. ( 28174808 )
2016
21
The King's Evil and the Royal Touch: the medical history of scrofula. ( 27155172 )
2016
22
Lymph node tuberculosis after allogeneic haematopoietic stem cell transplantation: an atypical presentation of an uncommon complication. ( 26015804 )
2015
23
Epidemiology of Peripheral Lymph Node Tuberculosis and Genotyping of M. tuberculosis Strains: A Case-Control Study. ( 26177546 )
2015
24
Delayed diagnosis of lymph node tuberculosis: time-honored importance of a thorough clinical examination, Cameroon. ( 26405474 )
2015
25
Diagnosis of lymph node tuberculosis using the GeneXpert MTB/RIF in Tunisia. ( 26964807 )
2015
26
Progenitor “Mycobacterium canettii” clone responsible for lymph node tuberculosis epidemic, Djibouti. ( 24520560 )
2014
27
A late presentation of isolated lymph node tuberculosis postintravesical BCG therapy for superficial bladder cancer: a novel case. ( 24792024 )
2014
28
Lymph node tuberculosis - an attempt of clinico-morphological study and review of the literature. ( 25178325 )
2014
29
Immune thrombocytopenia (ITP): a rare association of lymph node tuberculosis. ( 25327103 )
2014
30
Cat scratch disease and lymph node tuberculosis in a colon patient with cancer. ( 24334464 )
2013
31
Interstitial lung disease and profound hypoxaemia in a severely-malnourished child with very severe pneumonia and potential lymph-node tuberculosis: an uncommon but serious co-morbidity. ( 23617214 )
2013
32
Diagnostic usefulness of a T-cell-based assay in patients with miliary tuberculosis compared with those with lymph node tuberculosis. ( 23051762 )
2013
33
Pancreatic head region lymph node tuberculosis mimicking pancreatic solid pseudopapillary tumor. ( 23489813 )
2013
34
Systemic lymph node tuberculosis presenting with an aseptic psoas abscess caused by a paradoxical reaction after nine months of antituberculosis treatment: a case report. ( 23497500 )
2013
35
Diagnostic accuracy and effectiveness of the Xpert MTB/RIF assay for the diagnosis of HIV-associated lymph node tuberculosis. ( 23660698 )
2013
36
[Obstructive jaundice secondary to liver hilar lymph node tuberculosis]. ( 22817998 )
2013
37
Risk factors for prolonged treatment of lymph node tuberculosis. ( 22230257 )
2012
38
Isolated axillary lymph node tuberculosis in ultrasonography. A case report. ( 26674808 )
2012
39
Scrofula, the king's evil. ( 22371516 )
2012
40
Management of peripheral lymph node tuberculosis in routine practice: an unselected 10-year cohort. ( 21333106 )
2011
41
Genetic association study suggests a role for SP110 variants in lymph node tuberculosis but not pulmonary tuberculosis in north Indians. ( 21536091 )
2011
42
Assessment of lymph node tuberculosis in two provinces in Turkey. ( 21788708 )
2011
43
Sweet's syndrome in a patient with rheumatoid arthritis, Sjögren's syndrome and lymph node tuberculosis. ( 22714601 )
2011
44
Lymph node tuberculosis and paradoxical evolution. ( 20122063 )
2010
45
Treatment for lymph node tuberculosis. ( 20219818 )
2010
46
Lymph node tuberculosis. Time for a culture change? ( 20388678 )
2010
47
Lymph node tuberculosis in patients from regions with varying burdens of tuberculosis and human immunodeficiency virus (HIV) infection. ( 20646895 )
2010
48
Post-therapy paradoxical response in immunocompetent patients with lymph node tuberculosis. ( 20831881 )
2010
49
Epidemiological, therapeutic and evolutionary profiles in patients with lymph node tuberculosis. ( 21341113 )
2010
50
A historical vignette (18). The King's Evil: scrofula, physicians and the Royal Touch. ( 20681372 )
2010

Variations for Lymph Node Tuberculosis

Expression for Lymph Node Tuberculosis

Search GEO for disease gene expression data for Lymph Node Tuberculosis.

Pathways for Lymph Node Tuberculosis

GO Terms for Lymph Node Tuberculosis

Biological processes related to Lymph Node Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of neuron differentiation GO:0045666 9.37 FEZF1 FEZF2
2 forebrain development GO:0030900 9.32 FEZF1 FEZF2
3 regulation of neurogenesis GO:0050767 9.26 FEZF1 FEZF2
4 telencephalon development GO:0021537 9.16 FEZF1 FEZF2
5 cell dedifferentiation GO:0043697 8.96 FEZF1 FEZF2
6 forebrain anterior/posterior pattern specification GO:0021797 8.62 FEZF1 FEZF2

Sources for Lymph Node Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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