Lymph Node Tuberculosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology: ¹¹ An extrapulmonary tuberculosis that is located in lymph node, and has symptom lymphadenopathy, has symptom fever, has symptom weight loss, has symptom fatigue, has symptom night sweats and has symptom cough.

MalaCards based summary: Lymph Node Tuberculosis, also known as king's evil, is related to tuberculous peritonitis and lymphadenitis, and has symptoms including fatigue, fever and cough. An important gene associated with Lymph Node Tuberculosis is MIR4536-1 (MicroRNA 4536-1), and among its related pathways/superpathways are T-cell activation SARS-CoV-2 and Hematopoietic Stem Cells and Lineage-specific Markers. The drugs Antiviral Agents and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include lymph node, adrenal cortex and thyroid.

Sources

Related Diseases for Lymph Node Tuberculosis

Diseases related to Lymph Node Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 660)

#	Related Disease	Score	Top Affiliating Genes
1	tuberculous peritonitis	31.2	IFNG CRP ALB ADA
2	lymphadenitis	31.2	TNF IFNG CRP
3	skeletal tuberculosis	30.6	IFNG CRP
4	mycobacterium tuberculosis 1	30.4	TNF IFNG CRP CD4 ALB ADA
5	cat-scratch disease	30.3	CRP CD4
6	erythema nodosum	30.3	TNF IFNG CRP
7	pulmonary tuberculosis	30.2	TNF IFNG CRP ALB ADA
8	purpura	30.1	TNF IFNG CRP
9	cryptococcosis	30.1	TNF IFNG CD4
10	scleritis	30.1	TNF IFNG CRP
11	posterior scleritis	30.1	TNF IFNG CRP
12	interstitial lung disease	30.1	TNF IFNG CRP
13	osteomyelitis	30.1	TNF IFNG CRP
14	lymphangioma	30.1	TNF IFNG CD4
15	thyroiditis	30.1	TNF IFNG CRP
16	extrapulmonary tuberculosis	30.0	TNF IFNG CRP CD4 ALB ADA
17	mediastinitis	30.0	CRP CD4 ALB
18	parotitis	30.0	CRP CD4 ALB
19	spondylitis	29.9	TNF IFNG CRP
20	hemorrhagic disease	29.9	CRP CD4 ALB
21	cervical adenitis	29.9	TNF IFNG CRP CD4
22	colitis	29.9	TNF IFNG CRP CD4
23	keratoconjunctivitis	29.9	TNF IFNG ALB
24	hemorrhoid	29.9	TNF CRP ALB
25	paracoccidioidomycosis	29.9	TNF IFNG ALB
26	pleurisy	29.9	TNF IFNG CRP ADA
27	intracranial hypertension	29.8	TNF CRP ALB
28	peptic ulcer disease	29.8	TNF CRP ALB
29	immune deficiency disease	29.8	TNF IFNG CRP CD4 ADA
30	gout	29.7	TNF CRP ALB
31	sarcoidosis 1	29.7	TNF IFNG CRP CD4 ALB ADA
32	intestinal obstruction	29.7	TNF CRP ALB
33	multidrug-resistant tuberculosis	29.7	TNF IFNG CD4 ALB
34	demyelinating polyneuropathy	29.7	TNF CRP CD4 ALB
35	cellulitis	29.7	TNF CRP CD4 ALB
36	pneumonia	29.7	TNF IFNG CRP ALB
37	syphilis	29.7	TNF CRP CD4 ALB
38	bronchitis	29.7	TNF CRP ALB
39	pleural tuberculosis	29.7	TNF IFNG CRP CD4 ADA
40	alcohol use disorder	29.6	TNF CRP CD4 ALB
41	miliary tuberculosis	29.6	TNF IFNG CRP CD4 ALB ADA
42	otitis media	29.6	TNF IFNG CRP ALB
43	neutropenia	29.6	TNF IFNG CRP ALB
44	pancytopenia	29.6	IFNG CRP CD4 ALB
45	abdominal tuberculosis	29.5	TNF IFNG CRP CD4 ALB ADA
46	pneumocystosis	29.4	TNF IFNG CRP CD4 ALB
47	temporal arteritis	29.4	TNF IFNG CRP CD4 ALB
48	skin disease	29.4	TNF IFNG CRP CD4 ALB
49	thrombocytopenia	29.4	TNF IFNG CRP CD4 ALB
50	crohn's disease	29.3	TNF IFNG CRP CD4 ALB

Graphical network of the top 20 diseases related to Lymph Node Tuberculosis:

Sources

Symptoms & Phenotypes for Lymph Node Tuberculosis

Symptoms:

¹¹

• fatigue
• fever
• cough

• weight loss
• lymphadenopathy
• night sweats

Sources

Drugs & Therapeutics for Lymph Node Tuberculosis

Drugs for Lymph Node Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Antiviral Agents
2	Anti-Infective Agents
3	Fluorodeoxyglucose F18
4	Antimetabolites
5	Deoxyglucose

Interventional clinical trials:

#	Name	Status	NCT ID
1	Diagnosis of Mediastinal Tuberculous Lymphadenopathy by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA)	Unknown status	NCT01121432
2	Evaluation of Positron Emission Tomography in Extrapulmonary Tuberculosis	Completed	NCT01613196
3	Immunology Dysregulation in Lymphadenitis Tuberculosis : An Observational Study Using Patient' Block Paraffins 2019 Until 2021	Completed	NCT05202548

Search NIH Clinical Center for Lymph Node Tuberculosis

Cochrane evidence based reviews: king's evil

Sources

Genetic Tests for Lymph Node Tuberculosis

Sources

Anatomical Context for Lymph Node Tuberculosis

Organs/tissues related to Lymph Node Tuberculosis:

FMA: Lymph Node

MalaCards : Lymph Node, Adrenal Cortex, Thyroid, Lung, Skin, Salivary Gland, T Cells

Sources

Publications for Lymph Node Tuberculosis

Articles related to Lymph Node Tuberculosis:

(show top 50) (show all 1177)

#	Title	Authors	PMID	Year
1	Thyroid tuberculosis diagnosed as papillary thyroid carcinoma with fever of unknown origin. ⁶²	Kinoshita I...Kawata R	34657776	2022
2	The diagnostic and prognostic value of plasma circulating circNUP98 for nasopharyngeal carcinoma. ⁶²	Zhang B...He Y	36330641	2022
3	Retrospective observational study to compare Xpert MTB/RIF assay with other diagnostic tests in lymph node tuberculosis. ⁶²	Haridas N...Khan S	36412467	2022
4	Botanical Description, Traditional Uses, Phytochemistry, and Pharmacology of the Genus Artabotrys: A Review. ⁶²	Quang Hop N...The Son N	36222471	2022
5	The royal touch: Scrofula and defining monarchy. ⁶²	Goihman-Yahr M...Xu J	36202382	2022
6	Xpert MTB/RIF Ultra assay for tuberculosis disease and rifampicin resistance in children. ⁶²	Kay AW...Takwoingi Y	36065889	2022
7	Xpert MTB/RIF Assay for the Diagnosis of Lymph Node Tuberculosis in Children: A Systematic Review and Meta-Analysis. ⁶²	Chen HK...Guo XG	35956230	2022
8	Heterotopic squamous epithelial inclusion cyst in a cervical lymph node in a child: a case report and literature review. ⁶²	Huang P...Sun D	35958003	2022
9	Diagnosis and Management of Occult Cervical Tuberculous Lymphadenopathy. ⁶²	Li WX...Liu L	34842464	2022
10	An atypical presentation of tuberculous gumma heralding a diagnosis of lymph node tuberculosis: Hindsight is 20/20. ⁶²	Isoletta E...Brazzelli V	35542318	2022
11	Disseminated tuberculosis following invasive procedures for peripancreatic lymph node tuberculosis with portal vein obstruction: a case report. ⁶²	Kato A...Motomura Y	35334085	2022
12	An Adult Female Presenting With "Scrofula-Tubercular Lymphadenitis" a Rare Encounter: A Case Report. ⁶²	Sakhuja A...Joshi T	35785004	2022
13	A Novel Approach of Targeting Linezolid Nanoemulsion for the Management of Lymph Node Tuberculosis. ⁶²	Choudhary A...Iqbal Z	35571844	2022
14	Primary mediastinal lymph node tuberculosis diagnosed using endobronchial ultrasound-guided transbronchial needle aspiration: Literature review and case report. ⁶²	Cong CV...Duc NM	35345566	2022
15	Asymptomatic gastric tuberculosis in the gastric body mimicking an isolated microscopic erosion: A rare case report. ⁶²	Zhang W...Zhao L	35212291	2022
16	Bilateral optic neuritis as a first presentation of lymph node tuberculosis. ⁶²	Keshavan A...Khaleeli Z	34321330	2022
17	Prunella vulgaris L. - A Review of its Ethnopharmacology, Phytochemistry, Quality Control and Pharmacological Effects. ⁶²	Pan J...Chen Y	35814234	2022
18	Chinese endemic medicinal plant Bolbostemma paniculatum (Maxim.) Franquet: A comprehensive review. ⁶²	Zhou Y...Jin S	36160391	2022
19	Disseminated paracoccidioidomycosis associated with lymph node tuberculosis in a non immunocompromised child. ⁶²	Montalvo R...Tunque E	35663608	2022
20	A case of paradoxical reaction after treatment of generalized tuberculous lymphadenopathy in a peritoneal dialysis patient. ⁶²	Khan FG...Fan S	35308055	2022
21	Research of childhood tuberculosis in suspected populations by molecular methods: A multicenter study in China. ⁶²	Li C...Wang C	36339333	2022
22	The Role of Core Needle Biopsy Pathology Combined with Molecular Tests in the Diagnosis of Lymph Node Tuberculosis. ⁶²	Shen Y...Zhou L	35140479	2022
23	Dominant expansion of CD4+, CD8+ T and NK cells expressing Th1/Tc1/Type 1 cytokines in culture-positive lymph node tuberculosis. ⁶²	Kathamuthu GR...Babu S	35617254	2022
24	Some Manifestations of Tuberculosis in Otorhinolaryngology - Case Series and a Short Review of Related Data from South-Eastern Europe. ⁶²	Mocanu AI...Nechifor A	35668856	2022
25	Case Report: Primary Mediastinal Large B-Cell Lymphoma Invasion of Extranodal Thyroid Tissue Mimicking Tuberculosis and Confounded by Similar Ultrasonic Appearance. ⁶²	Wang Y...Yang G	35664739	2022
26	Analysis of misdiagnosis and 18F-FDG PET/CT findings of lymph node tuberculosis. ⁶²	Liao F...Yu J	35694951	2022
27	Hodgkin Lymphoma Mimicking Lumbar Spine Tuberculosis. ⁶²	Djossou HJ...Achemlal L	35251730	2022
28	Lymph Node Tuberculosis in Otolaryngological Practice: A Study of 68 Cases at the Sourô Sanou University Hospital of Bobo Dioulasso, Burkina Faso. ⁶²	Ouedraogo RW...Elola A	35605587	2022
29	Ultrasound-Based Radiomics Can Classify the Etiology of Cervical Lymphadenopathy: A Multi-Center Retrospective Study. ⁶²	Liu Y...Huang P	35656511	2022
30	Royal disease (Vasilios nósos): Substantiating one of the names of tuberculosis in Greek, from "Atakta" dictionary by Adamantios Korais, (1832-1835). ⁶²	Kazana AA...Gourgoulianis KI	35350256	2022
31	Rare presentation of tuberculous hypertrophic pachymeningitis diagnosed by a biopsy of abdominal lymphadenopathy. ⁶²	Yoshida M...Maeda T	35320986	2022
32	Historical Review of Ethnopharmacology in Karelia (1850s-2020s): Herbs and healers. ⁶²	Kolosova V...Soukand R	34496265	2022
33	A proposed CT classification of progressive lung parenchymal injury complicating pediatric lymphobronchial tuberculosis: From reversible to irreversible lung injury. ⁶²	Andronikou S...Goussard P	34515414	2021
34	Lymph Node Tuberculosis With Erythema Nodosum and Bone Nodules on Magnetic Resonance Imaging. ⁶²	Zhu D...Chen W	32925446	2021
35	Disseminated lymph node tuberculosis after splenectomy: an unusual case report in an adolescent. ⁶²	Cheng M...Chen Y	34819021	2021
36	Real-time next-generation sequencing on shell-vial culture to contribute to diagnosis of lymphatic tuberculosis: a case report. ⁶²	Morsli M...Drancourt M	34343856	2021
37	Miliary brain tuberculosis in an infant. ⁶²	Duc LA...Duc NM	34401018	2021
38	Utility of Fine Needle Aspiration Cytology (FNAC) in the diagnosis of tuberculous lymphadenitis compared to GeneXpert in a tertiary health care center in Northern Odisha, India. ⁶²	Gouda K...Dhangadamajhi G	34752310	2021
39	Mandibular tuberculosis fortuitously discovered after surgical resection of an ameloblastoma: A case report. ⁶²	Elzouiti Z...Tsen AE	34583263	2021
40	BCG re-vaccination in Malawi: 30-year follow-up of a large, randomised, double-blind, placebo-controlled trial. ⁶²	Glynn JR...Karonga Prevention Trial Group	34534489	2021
41	A review of Cremastra appendiculata (D.Don) Makino as a traditional herbal medicine and its main components. ⁶²	Liu J...Jin S	34166737	2021
42	[Analysis on specific effect of acupoints at the upper arms in treatment of scrofula and goiter]. ⁶²	Wang SZ...Zhao JP	34628753	2021
43	Intrahepatic arterial pseudoaneurysm secondary to lymph node tuberculosis. ⁶²	Sana L...Faouzi C	34455994	2021
44	Magnetic resonance imaging in response assessment of mediastinal tuberculous lymphadenopathy: Going beyond size. ⁶²	Singh R...Pandey S	34472520	2021
45	Tuberculosis lymph node granulomas: using transcriptomics to discover immunopathology paradigms and guide host-directed therapy. ⁶²	Phelan JJ...Keane J	34338227	2021
46	Diagnostic Performance of EUS-Guided Sampling in Indeterminate Radiological Diagnosis of Pancreatic Disease and Intra-Abdominal Lymphadenopathy. ⁶²	Jeon TY...Min SK	34501294	2021
47	Value of Serum Adenosine Deaminase (ADA) in Distinguishing between Tuberculous and Non-tuberculous Lymphadenopathies. ⁶²	Arafat SM...Azad AK	34226459	2021
48	Outcome of lymph node tuberculosis management with conventional treatment with and without prednisolone. ⁶²	Sharmin A...Khan MA	33427091	2021
49	[Clinical analysis of lateral cervical approach in the treatment of cervical lymphatic tuberculosis complicated with parapharyngeal space abscess]. ⁶²	Li Q...Ding C	34304486	2021
50	Vulval lymphangiectasia in pregnancy-a rare case report. ⁶²	Gunasekaran Kala P...Manivasakan J	33779006	2021

Sources

Genes for Lymph Node Tuberculosis

Genes related to Lymph Node Tuberculosis (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MIR4536-1	MicroRNA 4536-1	RNA Gene	6.01	DISEASES inferred ¹⁴
2	CES3	Carboxylesterase 3	Protein Coding	5.67	DISEASES inferred ¹⁴
3	CD4	CD4 Molecule	Protein Coding	5.58	DISEASES inferred ¹⁴
4	IFNG	Interferon Gamma	Protein Coding	5.3	DISEASES inferred ¹⁴
5	CRP	C-Reactive Protein	Protein Coding	5.05	DISEASES inferred ¹⁴
6	ADA	Adenosine Deaminase	Protein Coding	4.98	DISEASES inferred ¹⁴
7	EID2	EP300 Interacting Inhibitor Of Differentiation 2	Protein Coding	4.78	DISEASES inferred ¹⁴
8	TNF	Tumor Necrosis Factor	Protein Coding	4.77	DISEASES inferred ¹⁴
9	LTA4H	Leukotriene A4 Hydrolase	Protein Coding	4.75	DISEASES inferred ¹⁴
10	NAT9	N-Acetyltransferase 9 (Putative)	Protein Coding	4.74	DISEASES inferred ¹⁴
11	ALB	Albumin	Protein Coding	4.72	DISEASES inferred ¹⁴
12	TIMM10	Translocase Of Inner Mitochondrial Membrane 10	Protein Coding	4.64	DISEASES inferred ¹⁴
13	IFI44L	Interferon Induced Protein 44 Like	Protein Coding	4.6	DISEASES inferred ¹⁴

Sources

Variations for Lymph Node Tuberculosis

Sources

Expression for Lymph Node Tuberculosis

Search GEO for disease gene expression data for Lymph Node Tuberculosis.

Sources

Pathways for Lymph Node Tuberculosis

Pathways related to Lymph Node Tuberculosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	11.84	TNF IFNG CD4
2	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.61	TNF IFNG CD4
3	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.5	TNF IFNG CD4
4	Innate Lymphoid Cells Differentiation ⁶⁵	11.34	TNF IFNG CD4
5	THC Differentiation Pathway ⁶⁴	11.21	TNF IFNG CD4
6	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.2	TNF IFNG CD4
7	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	10.98	TNF IFNG CRP
8	Overview of nanoparticle effects ⁷⁴	10.74	TNF CRP
9	Selective expression of chemokine receptors during T-cell polarization ⁷⁴	10.58	IFNG CD4
10	Cytokines and inflammatory response ⁷⁴	10.26	TNF IFNG CD4

Sources

GO Terms for Lymph Node Tuberculosis

Biological processes related to Lymph Node Tuberculosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of amyloid-beta clearance	GO:1900222	9.62	TNF IFNG
2	negative regulation of lipid storage	GO:0010888	9.56	TNF CRP
3	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.46	TNF IFNG
4	positive regulation of nitrogen compound metabolic process	GO:0051173	9.26	TNF IFNG
5	positive regulation of vitamin D biosynthetic process	GO:0060557	8.92	TNF IFNG

Sources

Sources for Lymph Node Tuberculosis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LYM010 MIFTS: 41	Lymph Node Tuberculosis Categories: Immune diseases, Infectious diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables