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MCID: LYM021
MIFTS: 62

Lymphadenitis

Categories: Immune diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Lymphadenitis

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MalaCards integrated aliases for Lymphadenitis:

Name: Lymphadenitis 12 44 15 73
Chronic Lymphadenitis 12 73
Acute Lymphadenitis 12 73
Inflammation of Lymph Node 12
Chronic Adenitis 12
Acute Adenitis 12
Doid:1602 15
Adenitis 12

Classifications:

MalaCards categories:
Anatomical: Skin diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:1602
ICD9CM 35 289.1 683
MeSH 44 D008199
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Summaries for Lymphadenitis

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MalaCards based summary : Lymphadenitis, also known as chronic lymphadenitis, is related to aphthous stomatitis and human immunodeficiency virus infectious disease, and has symptoms including nausea and vomiting, abdominal pain and syncope. An important gene associated with Lymphadenitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Azithromycin and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, testes and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Lymphadenopathy or adenopathy is disease of the lymph nodes, in which they are abnormal in size, number,... more...

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Related Diseases for Lymphadenitis

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Diseases related to Lymphadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 499)
# Related Disease Score Top Affiliating Genes
1 aphthous stomatitis 31.5 IL10 IL1B TNF
2 human immunodeficiency virus infectious disease 30.4 IFNG IL10 TNF
3 appendicitis 30.4 CXCL8 IL10 IL1B TNF
4 meningitis 30.3 CXCL8 IFNG IL10 IL1B TNF
5 mixed connective tissue disease 30.2 IFNG IL10 TNF
6 familial mediterranean fever 30.2 IL1B NOD2 TNF
7 acquired immunodeficiency syndrome 30.1 IFNG IL10 IL1B TNF
8 adult-onset still's disease 30.1 IL18 IL1B TNF
9 ileitis 30.1 NOD2 TLR4 TNF
10 mycobacterium fortuitum 30.0 CXCL8 IFNGR1 IL12RB1
11 viral infectious disease 30.0 CD209 CXCL8 IFNG IL10 IL1B TNF
12 miliary tuberculosis 30.0 IFNG IL12RB1 TNF
13 fasciitis 30.0 CXCL8 IL18 TNF
14 aseptic meningitis 30.0 CXCL8 IFNG IL10 IL1B TNF
15 hemophagocytic lymphohistiocytosis 30.0 CXCL8 IFNG IL10 IL18 TNF
16 melioidosis 29.9 IFNG IL10 IL18 TLR4 TNF
17 cystitis 29.9 CXCL8 TLR4 TNF
18 toxoplasmosis 29.9 IFNG IL10 IL1B TLR4 TNF
19 myasthenia gravis 29.9 IFNG IL10 TNF
20 pericarditis 29.9 IFNG IL1B TNF
21 neuritis 29.9 IFNG IL1B TNF
22 cutaneous lupus erythematosus 29.9 CXCR3 ICAM1 IL18 TNF
23 ascaris lumbricoides infection 29.9 CXCL8 IFNG IL1B
24 intermediate uveitis 29.9 CXCR3 IFNG IL10 TNF
25 tonsillitis 29.8 CXCL8 IFNG IL1B TNF
26 pneumonia 29.8 CXCL8 IL10 IL1B TLR4 TNF
27 endocarditis 29.8 CXCL8 IL10 TNF
28 plasmodium falciparum malaria 29.8 ICAM1 IFNG IL10 IL18 TNF
29 systemic lupus erythematosus 29.8 CXCL8 CXCR3 FASLG ICAM1 IFNG IL10
30 osteomyelitis 29.7 CXCL8 IFNG IFNGR1 IL10 IL1B TNF
31 common variable immunodeficiency 29.7 CCR7 IFNG IL10 TNF
32 coccidioidomycosis 29.7 IFNGR1 IL10 TLR4
33 heart disease 29.7 CXCL8 ICAM1 IL10 IL1B TNF
34 pulmonary tuberculosis 29.7 IFNG IFNGR1 IL10 IL12RB1 IL18 SLC11A1
35 peritonitis 29.7 CXCL8 ICAM1 IL10 IL1B TNF
36 haemophilus influenzae 29.7 CXCL8 IL1B TNF
37 cysticercosis 29.7 IL18 IL1B TLR4
38 schistosomiasis 29.7 IFNG IFNGR1 IL10 TNF
39 dermatitis 29.6 CCL22 IFNG IL18 NOD2 STAT3
40 multidrug-resistant tuberculosis 29.6 IL10 SLC11A1 TNF
41 pleurisy 29.6 CXCL8 ICAM1 IFNG TNF
42 human immunodeficiency virus type 1 29.6 CCR7 CD209 IFNG IL10 TNF
43 erythema multiforme 29.5 CXCR3 FASLG ICAM1 IFNG TNF
44 bacterial sepsis 29.5 CXCL8 IL10 TLR4 TNF
45 toxic shock syndrome 29.5 CXCL8 IFNG IL10 IL1B TLR4 TNF
46 q fever 29.5 IFNG IL10 IL1B NOD2 TLR4 TNF
47 bone inflammation disease 29.5 CXCL8 IFNG IL10 IL1B TNF
48 uveitis 29.5 CXCR3 ICAM1 IFNG IL10 NOD2 TNF
49 otitis media 29.4 CXCL8 IL10 IL1B TLR4 TNF
50 cutaneous leishmaniasis 29.4 IFNG IL10 SLC11A1 TLR4 TNF

Comorbidity relations with Lymphadenitis via Phenotypic Disease Network (PDN):


Prostate Cancer

Graphical network of the top 20 diseases related to Lymphadenitis:



Diseases related to Lymphadenitis
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Symptoms & Phenotypes for Lymphadenitis

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UMLS symptoms related to Lymphadenitis:


nausea and vomiting, abdominal pain, syncope, fever of unknown origin, signs and symptoms of ill-defined conditions, (non-specific) malaise and fatigue, adenitis

GenomeRNAi Phenotypes related to Lymphadenitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.84 CASP3 CXCL8 ICAM1 IL10 IL18 IL1B
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.84 CASP3 CXCL8 ICAM1 IL10 IL18 IL1B

MGI Mouse Phenotypes related to Lymphadenitis:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.43 CASP3 CCR7 CXCR3 FASLG ICAM1 IFNG
2 immune system MP:0005387 10.42 CASP3 CCL22 CCR7 CXCR3 FASLG ICAM1
3 homeostasis/metabolism MP:0005376 10.39 CASP3 CCR7 CXCR3 FASLG ICAM1 IFNG
4 cellular MP:0005384 10.37 CASP3 CCR7 CXCR3 FASLG ICAM1 IFNG
5 digestive/alimentary MP:0005381 10.36 CASP3 CCR7 FASLG ICAM1 IFNG IFNGR1
6 cardiovascular system MP:0005385 10.35 CASP3 CXCR3 FASLG ICAM1 IFNG IFNGR1
7 mortality/aging MP:0010768 10.31 CASP3 CCL22 CXCR3 FASLG ICAM1 IFNG
8 integument MP:0010771 10.22 CASP3 FASLG ICAM1 IFNG IFNGR1 IL10
9 endocrine/exocrine gland MP:0005379 10.19 CASP3 CCR7 FASLG ICAM1 IFNG IFNGR1
10 neoplasm MP:0002006 10.11 CXCR3 FASLG ICAM1 IFNG IFNGR1 IL10
11 nervous system MP:0003631 10.1 CASP3 CCR7 FASLG ICAM1 IFNG IFNGR1
12 muscle MP:0005369 10.01 CASP3 ICAM1 IFNG IL10 IL18 STAT3
13 liver/biliary system MP:0005370 10 FASLG IFNG IFNGR1 IL10 STAT3 TLR4
14 renal/urinary system MP:0005367 9.8 CASP3 CXCR3 FASLG IFNG IFNGR1 STAT3
15 respiratory system MP:0005388 9.76 CASP3 CXCR3 FASLG IFNG IL10 STAT3
16 skeleton MP:0005390 9.65 CASP3 FASLG IFNG IFNGR1 IL10 IL1B
17 vision/eye MP:0005391 9.32 CASP3 CCR7 FASLG ICAM1 IFNG IL10
Sources

Drugs & Therapeutics for Lymphadenitis

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Drugs for Lymphadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 447043
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3 Hormone Antagonists Phase 4,Phase 3
4 Antineoplastic Agents, Hormonal Phase 4,Phase 3
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
6 glucocorticoids Phase 4,Phase 3
7 Hormones Phase 4,Phase 3
8 Anti-Inflammatory Agents Phase 4,Phase 3
9
Petrolatum Approved, Investigational Phase 3 8009-03-8
10
Silver sulfadiazine Approved, Vet_approved Phase 3 22199-08-2 441244
11
Sulfadiazine Approved, Investigational, Vet_approved Phase 3 68-35-9 5215
12
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
13
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
14
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
15
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
16
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
17
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
18
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
19 Anti-Infective Agents Phase 3,Not Applicable
20 Antiparasitic Agents Phase 3
21 Emollients Phase 3
22 Antiprotozoal Agents Phase 3
23 Dermatologic Agents Phase 3
24 Anti-Infective Agents, Local Phase 3
25 Anti-Bacterial Agents Phase 3
26 beta-Lactamase Inhibitors Phase 3
27 Clavulanic Acids Phase 3
28 Amoxicillin-Potassium Clavulanate Combination Phase 3
29 Gentamicins Phase 3
30 Antimalarials Phase 3
31 Antibiotics, Antitubercular Phase 3
32 Prednisolone acetate Phase 3
33 Autonomic Agents Phase 3
34 Neuroprotective Agents Phase 3
35 Peripheral Nervous System Agents Phase 3
36 Antiemetics Phase 3
37 Gastrointestinal Agents Phase 3
38 Protective Agents Phase 3
39 Methylprednisolone acetate Phase 3
40 Immunologic Factors Phase 1,Not Applicable
41 Immunoglobulins Phase 1
42 Antibodies, Monoclonal Phase 1
43 Antibodies Phase 1
44
Ethanol Approved Not Applicable 64-17-5 702
45
Formaldehyde Approved, Vet_approved Not Applicable 50-00-0 712
46
BCG vaccine Investigational Not Applicable
47 Disinfectants Not Applicable
48 Adjuvants, Immunologic Not Applicable
49 Vaccines Not Applicable

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
2 A Trial Comparing the Efficacy and Safety of Open Dressing With Petrolatum Jelly vs. Standard Gauze Dressing With Silver Sulfadiazine Completed NCT02109718 Phase 3 Open Dressings with Petrolatum Jelly;Silver Sulfadiazine Gauze Dressing Group
3 Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis Recruiting NCT03132116 Phase 3 gentamicin;placebo
4 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka Recruiting NCT02929134 Phase 3 Doxycycline;Placebo
5 A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali Recruiting NCT02927496 Phase 3 Doxycycline;Placebo
6 Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone Recruiting NCT02281929 Phase 3 Amoxicillin;Placebo;Prednisolone
7 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India Not yet recruiting NCT02929121 Phase 3 Doxycycline;Placebo
8 Comparison of Antibiotic Therapy Alone or Combined With Corticosteroids for the Treatment of Nontuberculous Mycobacterial Cervicofacial Lymphadenitis in Children: A Randomized Double-Blind Placebo-Controlled Study Withdrawn NCT01614977 Phase 3 Methylprednisoline
9 Systemic and Local Antimicrobials in the Management of Dental Abscess in Children Recruiting NCT03761264 Phase 2 Odontopaste®;Pulpdent;Amoxicillin
10 Probiotics and Corticosteroids for Treating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) Withdrawn NCT02535962 Phase 2
11 Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Recruiting NCT02775994 Phase 1 Canakinumab
12 Linear Endosonography for the Assessment of Sarcoidosis Stage O Unknown status NCT01383226 Not Applicable
13 Diagnostic Accuracy of Polymerase Chain Reaction for Mycobacterium Tuberculosis Using EBUS-TBNA Samples Unknown status NCT02497079 Not Applicable
14 Ultrasonographic Differentiation Between Kikuchi's Disease and Lymphoma in Patients With Cervical Lymphadenopathy Unknown status NCT01310933
15 Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) Completed NCT01406275 Amoxicillin and clavulanate
16 Efficacy Study of Thrice Weekly Directly Observed Treatment Short-Course Regimen in Tubercular Pleural Effusion Completed NCT01560078
17 Tonsillotomy or Follow-up in PFAPA Syndrome Recruiting NCT03331497 Not Applicable
18 Explanations for Negative Laparoscopic Appendectomies and Normal Laparoscopies Recruiting NCT03349814
19 Study of Bcg Scars of Under Five Years Old Children in Assiut University Hospital Not yet recruiting NCT03548233 Not Applicable
20 Clinical Studies of Kikuchi's Disease Withdrawn NCT00172445 Not Applicable

Search NIH Clinical Center for Lymphadenitis

Cochrane evidence based reviews: lymphadenitis

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Genetic Tests for Lymphadenitis

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Anatomical Context for Lymphadenitis

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MalaCards organs/tissues related to Lymphadenitis:

41
Lymph Node, Testes, T Cells, Breast, Thyroid, Lung, Skin
Sources

Publications for Lymphadenitis

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Articles related to Lymphadenitis:

(show top 50) (show all 1357)
# Title Authors Year
1
Evaluation of loop mediated isothermal amplification (LAMP) assay in the diagnosis of tubercular lymphadenitis: A pilot study. ( 29332654 )
2018
2
Histiocytic necrotising lymphadenitis identical to Kikuchi-Fujimoto disease in CNS lupus. ( 29884722 )
2018
3
Multidrug-resistant Tuberculosis Lymphadenitis as the Initial Presentation of Secondary Multidrug-resistant Tuberculosis: A Case Report. ( 29805932 )
2018
4
Toxoplasmosis submandibular lymphadenitis: Report of an unusual case with a brief review. ( 29731568 )
2018
5
Lymphadenitis and Lymphadenopathy. ( 29131085 )
2018
6
Epitrochlear lymphadenitis mimicking subcutaneous abscess. ( 29444798 )
2018
7
Histological Comparison Of Two Staining Methods In Identification Of Mycobacterium Tuberculosis In Granulomatous Lymphadenitis. ( 29938410 )
2018
8
Human Herpes Virus 6 (HHV-6)-associated Lymphadenitis: Pitfalls in Diagnosis in Benign and Malignant Settings. ( 29975251 )
2018
9
Conservative treatment for cutaneous fistula resulted from abscess formation in patients with tuberculous cervical lymphadenitis. ( 29402607 )
2018
10
Diminished circulating plasma and elevated lymph node culture supernatant levels of IL-10 family cytokines in tuberculous lymphadenitis. ( 29871780 )
2018
11
Metastatic tubercular gummas and splenic tuberculoma secondary to tubercular lymphadenitis in an immunocompetent female. ( 29892975 )
2018
12
BCG-Induced Granulomatous Balanoposthitis and Lymphadenitis Unresponsive to Isoniazid Therapy: A Case Report and Review of theA Literature. ( 29463439 )
2018
13
Cervicofacial lymphadenitis due to<i>Mycobacterium mantenii:</i>rapid and reliable identification by MALDI-TOF MS. ( 29348923 )
2018
14
Association of Corynebacterium pseudotuberculosis recombinant proteins rCP09720 or rCP01850 with rPLD as immunogens in caseous lymphadenitis immunoprophylaxis. ( 29174312 )
2018
15
Leader gene of Corynebacterium pseudotuberculosis may be useful in vaccines against caseous lymphadenitis of goats: a bioinformatics approach. ( 29937460 )
2018
16
Purulent lymphadenitis caused by Staphylococcus argenteus, representing the first Japanese case of Staphylococcus argenteus (multilocus sequence type 2250) infection in a 12-year-old boy. ( 29709375 )
2018
17
Necrotizing lymphadenitis: If not tuberculosis then what? ( 29915771 )
2018
18
Severe Disseminated Necrotizing and Granulomatous Lymphadenitis and Encephalitis in a Dog Due to Sporotrichum pruinosum (Teleomorph: Phanerochaete chrysosporium). ( 29191132 )
2018
19
Minimally invasive approach to suppurated cervical lymphadenitis in children: Our experience on 60 patients. ( 29687954 )
2018
20
Image Gallery: Cervical lymphadenitis as an unusual presentation of disseminated coccidioidomycosis. ( 29897112 )
2018
21
Toxoplasma lymphadenitis caused by ingestion of raw blood and meat of deer in a 10-year-old boy. ( 29884335 )
2018
22
Unusual wound healing following suppurative BCG lymphadenitis. ( 29848543 )
2018
23
Severe bacterial sepsis results in delayed diagnosis of tuberculous lymphadenitis in a rheumatoid arthritis patient treated with adalimumab. ( 29862158 )
2018
24
Syphilitic lymphadenitis with abscess formation involving cervical lymph nodes. ( 29438971 )
2018
25
Kikuchi's disease (histiocytic necrotizing lymphadenitis): A rare presentation with acute kidney injury, peripheral neuropathy, and aseptic meningitis with cutaneous involvement. ( 29567898 )
2018
26
Mycobacterium lentiflavum as the main cause of lymphadenitis in pediatric population. ( 29395439 )
2018
27
Fine-needle aspiration cytology of leishmanial lymphadenitis in an HIV-reactive patient: Report of a rare case. ( 29930909 )
2018
28
Genotyping and molecular detection of multidrug-resistant <i>Mycobacterium tuberculosis</i> among tuberculosis lymphadenitis cases in Addis Ababa, Ethiopia. ( 29675262 )
2018
29
Lymphadenitis associated with cat-scratch disease simulating a neoplasm: Imaging findings with histopathological associations. ( 29399138 )
2018
30
Reactive Lymphoid Hyperplasia or Tubercular Lymphadenitis: Can Real-Time PCR on Fine-Needle Aspirates Help Physicians in Concluding the Diagnosis? ( 29763927 )
2018
31
Histiocytic Necrotizing Lymphadenitis Involving the Neck: Radiology-Pathology Correlation. ( 29858834 )
2018
32
Noncaseating suppurative granulomatous lymphadenitis in adult onset Still's disease - a diagnostic dilemma in a tuberculosis-endemic region: a case report. ( 30318016 )
2018
33
A Case of Generalized, Superinfected Dermatitis and Inguinal Mycobacterium Lymphadenitis - TB or not TB? ( 30390733 )
2018
34
FDG-PET/CT findings, the vital clue to rare diagnosis of herpes simplex virus lymphadenitis simulating Richter transformation. ( 30471841 )
2018
35
Three children of meningoencephalitis with Kikuchi necrotizing lymphadenitis. ( 29050838 )
2018
36
Cervical tuberculous lymphadenitis: diagnosis and demographics, a five-year case series in the UK. ( 29484929 )
2018
37
Ectopic Enterobius Vermicularis Infestation; An Extremely Rare Cause Of Mesenteric Lymphadenopathy Mimicking Tuberculous Lymphadenitis. ( 29504348 )
2018
38
Cervical Tuberculous Lymphadenitis. ( 29523421 )
2018
39
Brain abscess and cervical lymphadenitis due to Paraclostridium bifermentans: A report of two cases. ( 29526826 )
2018
40
Radiographic and computed tomographic appearance of caseous lymphadenitis in a goat. ( 29544023 )
2018
41
Disseminated tuberculous lymphadenitis presenting as cervical mass in patient with HIV infection, worsening after antiretroviral initiation: diagnosis and treatment challenges. ( 29545423 )
2018
42
Emergence of Nontuberculous Mycobacterial Lymphadenitis in Children After the Discontinuation of Mandatory Bacillus Calmette and GuÉrin Immunization in France. ( 29570591 )
2018
43
Efficacy of Fine-Needle Aspiration Cytology in the Diagnosis of Tuberculous Cervical Lymphadenitis. ( 29587250 )
2018
44
Molecular strategy for the diagnosis of infectious lymphadenitis. ( 29594802 )
2018
45
Surgical treatment for chronic cervical lymphadenitis in children. Experience from a tertiary care paediatric centre on non-tuberculous mycobacterial infections. ( 29605343 )
2018
46
Extensive Lepromatous Lymphadenitis Preceding Lesions on the Face and Earlobes: An Unusual Presentation of Leprosy in Singapore. ( 29606944 )
2018
47
Chronic Neutropenia in Children with Abscess Forming Cervical Lymphadenitis Caused by Staphylococcus aureus. ( 29613972 )
2018
48
Tuberculous lymphadenitis is associated with altered levels of circulating angiogenic factors. ( 29663962 )
2018
49
Unusual case of cerebral demyelination and bilateral optic neuritis in an infant with suppurative BCG lymphadenitis. ( 29848532 )
2018
50
Does Clarithromycin Cause Hearing Loss? A 12-Year Review of Clarithromycin Therapy for Nontuberculous Mycobacterial Lymphadenitis in Children. ( 30032669 )
2018
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Variations for Lymphadenitis

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Expression for Lymphadenitis

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Search GEO for disease gene expression data for Lymphadenitis.
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Pathways for Lymphadenitis

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Pathways related to Lymphadenitis according to GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14.14 CASP3 CCL22 CD209 CXCL8 FASLG ICAM1
2
ERK Signaling 64
Show member pathways
 13.99 CASP3 CCL22 CCR7 CXCL8 CXCL9 CXCR3
3
PEDF Induced Signaling 64
Show member pathways
 13.72 CASP3 CCL22 CCR7 CXCL8 CXCL9 CXCR3
4
TGF-Beta Pathway 64
Show member pathways
 13.68 CCL22 CXCL8 ICAM1 IFNG IFNGR1 IL10
5
Integrin Pathway 64
Show member pathways
 13.5 CASP3 CCL22 CCR7 CXCL8 CXCL9 CXCR3
6
Akt Signaling 64
Show member pathways
 13.5 CASP3 CCL22 CCR7 CXCL8 CXCL9 CXCR3
7
PAK Pathway 64
Show member pathways
 13.45 CASP3 CCL22 CCR7 CXCL8 CXCL9 CXCR3
8
Cytokine Signaling in Immune system 66
Show member pathways
 13.41 CASP3 CCL22 CXCL8 FASLG ICAM1 IFNG
9
Human cytomegalovirus infection 37
Show member pathways
 13.21 CASP3 CXCL8 FASLG ICAM1 IFNGR1 IL1B
10
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 13.18 CXCL8 CXCL9 FASLG IFNG IFNGR1 IL10
11
CCR5 Pathway in Macrophages 64
Show member pathways
 13.03 CCL22 CCR7 CXCL8 CXCL9 CXCR3 FASLG
12
Pathways in cancer 37
12.99 CASP3 CXCL8 FASLG IFNG IFNGR1 IL12RB1
13
Allograft rejection 1 37
Show member pathways
 12.95 CASP3 CXCL8 CXCL9 FASLG ICAM1 IFNG
14
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.89 CXCL8 IFNG IL18 IL1B TLR4 TNF
15
4-1BB Pathway 64
Show member pathways
 12.85 CASP3 FASLG IFNG IFNGR1 IL1B STAT3
16
Immune response IL-23 signaling pathway 22
Show member pathways
 12.79 CXCL9 IFNG IL10 IL12RB1 IL18 IL1B
17
Influenza A 37
Show member pathways
 12.79 CASP3 CD209 CXCL8 FASLG ICAM1 IFNG
18
Immune response NFAT in immune response 22
Show member pathways
 12.77 IFNG IFNGR1 IL10 IL12RB1 IL18 TNF
19
Th17 cell differentiation 37
Show member pathways
 12.73 IFNG IFNGR1 IL10 IL12RB1 IL18 IL1B
20
NF-kappaB Signaling 4
12.72 FASLG IFNG IL10 IL1B STAT3 TNF
21
TRAF Pathway 64
Show member pathways
 12.7 CASP3 FASLG IL1B TLR4 TNF
22
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.68 CASP3 FASLG ICAM1 IFNG IFNGR1 TNF
23
JAK-STAT signaling pathway (KEGG) 37
Show member pathways
 12.51 IFNG IFNGR1 IL10 IL12RB1 STAT3
24
IL-17 Family Signaling Pathways 65
Show member pathways
 12.51 CASP3 CXCL8 IFNG IL1B STAT3 TNF
25
Toll Comparative Pathway 64
Show member pathways
 12.49 CXCL8 IFNG IFNGR1 IL1B TLR4 TNF
26
T cell receptor signaling pathway 37
Show member pathways
 12.48 IFNG IL10 IL1B TNF
27
Toxoplasmosis 37
Show member pathways
 12.45 CASP3 IFNG IFNGR1 IL10 IL1B STAT3
28
Proteoglycans in cancer 37
12.44 CASP3 FASLG STAT3 TLR4 TNF
29
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.42 CXCL8 IFNG IL10 IL18 IL1B TNF
30
Selenium Micronutrient Network 1
Show member pathways
 12.41 ICAM1 IFNG IL1B TNF
31
Necroptosis 37
Show member pathways
 12.41 FASLG IFNG IFNGR1 IL1B STAT3 TLR4
32
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 12.39 CCL22 CCR7 CXCL8 CXCL9 CXCR3 ICAM1
33
Bacterial infections in CF airways 22
Show member pathways
 12.39 CXCL8 FASLG IFNG IFNGR1 IL1B TLR4
34
Epstein-Barr virus infection 37
12.37 CASP3 ICAM1 STAT3 TNF
35
C-type lectin receptor signaling pathway 37
Show member pathways
 12.37 CCL22 CD209 IL10 IL1B TNF
36
Colorectal Cancer Metastasis 64
12.37 CASP3 IFNG IFNGR1 STAT3 TLR4 TNF
37
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.34 CASP3 CXCL8 IL10 IL1B TNF
38
IL-1 Family Signaling Pathways 65
Show member pathways
 12.31 CXCL8 IL18 IL1B TNF
39
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.26 CCL22 CXCL8 ICAM1 IFNG IFNGR1 IL10
40
Spinal Cord Injury 1
12.22 CASP3 CXCL8 ICAM1 IFNG IL1B TLR4
41
Fluid shear stress and atherosclerosis 37
12.2 ICAM1 IFNG IL1B TNF
42
IL12-mediated signaling events 1
Show member pathways
 12.19 FASLG IFNG IL12RB1 IL18 IL1B STAT3
43
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 65
Show member pathways
 12.18 CCL22 CCR7 CXCL8 CXCL9 CXCR3
44
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
12.17 CCR7 CD209 IFNG IL10 TNF
45
Osteoclast differentiation 37
12.16 IFNG IFNGR1 IL1B TNF
46
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 12.15 IFNG IL1B TLR4 TNF
47
TNF signaling pathway 37
12.15 CASP3 ICAM1 IL1B NOD2 TNF
48
Th1 Differentiation Pathway 65
Show member pathways
 12.14 IFNG IFNGR1 IL10 IL12RB1 IL18 IL1B
49
AGE-RAGE signaling pathway in diabetic complications 37
12.13 CASP3 CXCL8 ICAM1 IL1B STAT3 TNF
50
Tuberculosis 37
12.11 CASP3 CD209 IFNG IFNGR1 IL10 IL18
Sources

GO Terms for Lymphadenitis

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Cellular components related to Lymphadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.96 CCL22 CD209 CXCL8 CXCL9 FASLG IFNG
2 extracellular space GO:0005615 9.85 CCL22 CXCL8 CXCL9 FASLG ICAM1 IFNG
3 membrane raft GO:0045121 9.62 CASP3 FASLG ICAM1 TNF
4 cell surface GO:0009986 9.56 CCR7 CD209 CXCR3 FASLG ICAM1 NOD2
5 external side of plasma membrane GO:0009897 9.28 CCR7 CD209 CXCL9 CXCR3 FASLG ICAM1

Biological processes related to Lymphadenitis according to GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Name GO ID Score Top Affiliating Genes
1 response to organic cyclic compound GO:0014070 9.99 CASP3 ICAM1 IL1B STAT3
2 activation of MAPK activity GO:0000187 9.99 IL1B NOD2 TLR4 TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.99 ICAM1 IL18 IL1B NOD2 TLR4 TNF
4 response to virus GO:0009615 9.98 CCL22 IFNG IFNGR1 TNF
5 immune response GO:0006955 9.97 CCL22 CCR7 CXCL8 CXCL9 CXCR3 FASLG
6 cellular response to interferon-gamma GO:0071346 9.96 CCL22 ICAM1 IL12RB1 TLR4
7 positive regulation of JNK cascade GO:0046330 9.96 CCR7 IL1B NOD2 TLR4 TNF
8 response to organic substance GO:0010033 9.95 CASP3 IL10 STAT3 TNF
9 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.94 CASP3 FASLG TNF
10 calcium-mediated signaling GO:0019722 9.94 CCR7 CXCL8 CXCR3
11 neutrophil chemotaxis GO:0030593 9.94 CCL22 CXCL8 CXCL9 IL1B
12 cell chemotaxis GO:0060326 9.93 CCL22 CCR7 CXCR3
13 cellular response to interleukin-1 GO:0071347 9.93 CCL22 CXCL8 ICAM1
14 response to glucocorticoid GO:0051384 9.93 CASP3 IL10 IL1B TNF
15 chemokine-mediated signaling pathway GO:0070098 9.93 CCL22 CCR7 CXCL8 CXCL9 CXCR3
16 positive regulation of inflammatory response GO:0050729 9.92 IL18 TLR4 TNF
17 interferon-gamma-mediated signaling pathway GO:0060333 9.92 ICAM1 IFNG IFNGR1
18 apoptotic signaling pathway GO:0097190 9.92 CASP3 FASLG TLR4 TNF
19 positive regulation of interleukin-6 production GO:0032755 9.92 IL1B NOD2 TLR4 TNF
20 response to lipopolysaccharide GO:0032496 9.92 CASP3 CCR7 FASLG ICAM1 IL10 IL1B
21 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.91 IFNG IL18 STAT3
22 regulation of inflammatory response GO:0050727 9.91 NOD2 TLR4 TNF
23 regulation of insulin secretion GO:0050796 9.91 IFNG IL1B TNF
24 positive regulation of neuron apoptotic process GO:0043525 9.9 CASP3 FASLG IL1B
25 interleukin-12-mediated signaling pathway GO:0035722 9.89 IFNG IL10 IL12RB1
26 extrinsic apoptotic signaling pathway GO:0097191 9.89 FASLG IFNG TNF
27 cellular response to organic substance GO:0071310 9.89 CASP3 ICAM1 IL1B
28 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.89 IL18 IL1B NOD2 TLR4 TNF
29 regulation of cell adhesion GO:0030155 9.88 CXCL8 ICAM1 IL18
30 lipopolysaccharide-mediated signaling pathway GO:0031663 9.88 IL18 IL1B TLR4 TNF
31 cellular response to organic cyclic compound GO:0071407 9.88 CASP3 IL18 IL1B NOD2 STAT3 TNF
32 positive regulation of phagocytosis GO:0050766 9.87 IL1B SLC11A1 TNF
33 positive regulation of interleukin-8 production GO:0032757 9.87 IL1B NOD2 TLR4 TNF
34 negative regulation of interleukin-6 production GO:0032715 9.86 IL10 TLR4 TNF
35 cellular response to lipopolysaccharide GO:0071222 9.86 CXCL8 CXCL9 ICAM1 IL10 IL1B NOD2
36 positive regulation of nitric oxide biosynthetic process GO:0045429 9.85 ICAM1 IFNG IL1B TLR4 TNF
37 positive regulation of interferon-gamma production GO:0032729 9.85 IL12RB1 IL18 IL1B SLC11A1 TLR4 TNF
38 positive regulation of interleukin-12 production GO:0032735 9.84 CCR7 IFNG TLR4
39 leukocyte chemotaxis GO:0030595 9.83 CXCL8 CXCL9 IL10
40 positive regulation of neutrophil chemotaxis GO:0090023 9.83 CCR7 CXCL8 IL1B
41 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.81 IFNG IL1B TNF
42 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.8 IL10 IL1B TNF
43 positive regulation of dendritic cell antigen processing and presentation GO:0002606 9.77 CCR7 NOD2 SLC11A1
44 positive regulation of interleukin-17 production GO:0032740 9.76 IL18 NOD2
45 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.76 IFNG IFNGR1
46 interferon-gamma production GO:0032609 9.76 IL18 TLR4
47 negative regulation of interleukin-17 production GO:0032700 9.76 IFNG TLR4
48 response to molecule of bacterial origin GO:0002237 9.75 CXCL8 IL10
49 macrophage activation GO:0042116 9.75 SLC11A1 TLR4
50 neutrophil activation GO:0042119 9.75 CXCL8 IL18

Molecular functions related to Lymphadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 CCL22 CXCL8 CXCL9 FASLG IFNG IL10
2 chemokine activity GO:0008009 9.13 CCL22 CXCL8 CXCL9
Sources

Sources for Lymphadenitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
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46 MGI
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51 NDF-RT
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55 Novoseek
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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