Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Academic Licensing Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: LYM021
MIFTS: 61

Lymphadenitis

Categories: Skin diseases, Immune diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Lymphadenitis

About this section

MalaCards integrated aliases for Lymphadenitis:

Name: Lymphadenitis 12 44 15 73
Chronic Lymphadenitis 12 73
Acute Lymphadenitis 12 73
Inflammation of Lymph Node 12
Chronic Adenitis 12
Acute Adenitis 12
Adenitis 12

Classifications:

MalaCards categories:
Anatomical: Skin diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 33


Sources

Summaries for Lymphadenitis

About this section
MalaCards based summary : Lymphadenitis, also known as chronic lymphadenitis, is related to mixed connective tissue disease and appendicitis, and has symptoms including abdominal pain, adenitis and fever of unknown origin. An important gene associated with Lymphadenitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Azithromycin and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, testes and skin, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Sources

Related Diseases for Lymphadenitis

About this section

Diseases related to Lymphadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 411)
# Related Disease Score Top Affiliating Genes
1 mixed connective tissue disease 30.6 IFNG IL10 TNF
2 appendicitis 30.6 CXCL8 IL10 IL1B TNF
3 adult-onset still's disease 30.4 IL18 IL1B TNF
4 mycobacterium fortuitum 30.4 CXCL8 IFNGR1 IL12RB1
5 chronic granulomatous disease 30.3 IFNG IL1B TNF
6 neuritis 30.2 IFNG IL1B TNF
7 cysticercosis 30.2 IL18 IL1B TLR4
8 acquired immunodeficiency syndrome 30.2 IFNG IL10 IL1B TNF
9 tonsillitis 30.1 CXCL8 IFNG IL1B TNF
10 myasthenia gravis 30.0 IFNG IL10 TNF
11 multidrug-resistant tuberculosis 30.0 IL10 SLC11A1 TNF
12 meningitis 29.9 CXCL8 IFNG IL10 IL1B TNF
13 duodenal ulcer 29.9 CXCL8 IL1B TNF
14 schistosomiasis 29.9 IFNG IFNGR1 IL10 TNF
15 endocarditis 29.9 CXCL8 IL10 TNF
16 toxoplasmosis 29.8 IFNG IL10 IL1B TLR4 TNF
17 hemophagocytic lymphohistiocytosis 29.8 CXCL8 IFNG IL10 IL18 TNF
18 aseptic meningitis 29.8 CXCL8 IFNG IL10 IL1B TNF
19 prostatitis 29.7 CXCL8 IL10 IL1B TNF
20 melioidosis 29.7 IFNG IL10 IL18 TLR4 TNF
21 cutaneous lupus erythematosus 29.7 CXCR3 ICAM1 IL18 TNF
22 osteomyelitis 29.6 CXCL8 IFNG IFNGR1 IL1B TNF
23 pleurisy 29.5 CXCL8 ICAM1 IFNG TNF
24 radiculopathy 29.5 CXCL8 CXCR3 IL10
25 pneumonia 29.5 CXCL8 IL10 IL1B TLR4 TNF
26 ileitis 29.4 NOD2 TLR4 TNF
27 peritonitis 29.4 CXCL8 ICAM1 IL10 IL1B TNF
28 human immunodeficiency virus type 1 29.3 CCR7 CD209 IFNG IL10 TNF
29 granulomatous dermatitis 29.2 NOD2 TNF
30 arthritis 29.2 CXCL8 IFNG IL10 IL18 IL1B TNF
31 otitis media 29.2 CXCL8 IL10 IL1B TLR4 TNF
32 erythema multiforme 29.0 CXCR3 FASLG ICAM1 IFNG TNF
33 systemic lupus erythematosus 29.0 CXCR3 FASLG ICAM1 IFNG IL10 IL18
34 chlamydia 28.7 CXCL8 IFNG IL10 IL1B TLR4 TNF
35 pulmonary tuberculosis 28.6 IFNG IFNGR1 IL10 IL12RB1 IL18 SLC11A1
36 salmonellosis 28.4 IFNG IFNGR1 IL12RB1 IL18 IL1B SLC11A1
37 ulcerative colitis 27.7 CXCL8 IL10 IL1B NOD2 TLR4 TNF
38 colitis 27.5 CXCL8 IFNG IL10 IL1B NOD2 TLR4
39 rheumatoid arthritis 27.0 CXCL8 ICAM1 IFNG IL10 IL18 IL1B
40 periodic fever, aphthous stomatitis, pharyngitis and adenitis 12.4
41 mesenteric lymphadenitis 12.3
42 kikuchi disease 12.2
43 suppurative lymphadenitis 12.1
44 postauricular lymphadenitis 11.9
45 cervical adenitis 11.4
46 submandibular adenitis 11.3
47 kawasaki disease 11.2
48 lymphogranuloma venereum 11.2
49 mycobacterium malmoense 11.2
50 punctate inner choroidopathy 11.0 IL10 TNF

Comorbidity relations with Lymphadenitis via Phenotypic Disease Network (PDN):


Prostate Cancer

Graphical network of the top 20 diseases related to Lymphadenitis:



Diseases related to Lymphadenitis
Sources

Symptoms & Phenotypes for Lymphadenitis

About this section

UMLS symptoms related to Lymphadenitis:


abdominal pain, adenitis, fever of unknown origin, (non-specific) malaise and fatigue, nausea and vomiting, syncope, signs and symptoms of ill-defined conditions

GenomeRNAi Phenotypes related to Lymphadenitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.84 IL10 IL18 IL1B NOD2 CASP3 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.84 IL10 IL18 IL1B NOD2 CASP3 TNF

MGI Mouse Phenotypes related to Lymphadenitis:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.43 FASLG CCR7 ICAM1 CXCR3 CASP3 IFNG
2 immune system MP:0005387 10.42 FASLG CCL22 CCR7 ICAM1 CXCR3 CASP3
3 homeostasis/metabolism MP:0005376 10.39 FASLG CCR7 CXCR3 CASP3 IFNG IL10
4 digestive/alimentary MP:0005381 10.37 FASLG CCR7 ICAM1 CASP3 IFNG IL10
5 cardiovascular system MP:0005385 10.35 CASP3 FASLG CXCR3 IFNGR1 IFNG IL10
6 cellular MP:0005384 10.35 CASP3 FASLG CCR7 CXCR3 IFNGR1 IFNG
7 mortality/aging MP:0010768 10.31 CASP3 FASLG CCL22 CXCR3 IFNGR1 IFNG
8 growth/size/body region MP:0005378 10.28 CASP3 ICAM1 IFNG NOD2 IL18 SOCS1
9 integument MP:0010771 10.22 FASLG ICAM1 CASP3 IFNG IL10 IFNGR1
10 endocrine/exocrine gland MP:0005379 10.2 CASP3 FASLG CCR7 ICAM1 IFNGR1 IFNG
11 neoplasm MP:0002006 10.11 FASLG ICAM1 CXCR3 IFNG IL10 IFNGR1
12 nervous system MP:0003631 10.06 CASP3 FASLG CCR7 ICAM1 IFNGR1 IFNG
13 muscle MP:0005369 10.01 CASP3 ICAM1 IFNG IL10 IL18 SOCS1
14 liver/biliary system MP:0005370 10 FASLG IFNGR1 IFNG SOCS1 IL10 TNF
15 renal/urinary system MP:0005367 9.8 CXCR3 CASP3 FASLG IFNGR1 IFNG SOCS1
16 respiratory system MP:0005388 9.76 CXCR3 CASP3 FASLG IFNG IL10 SOCS1
17 skeleton MP:0005390 9.61 CASP3 FASLG IFNGR1 IFNG IL10 NOD2
18 vision/eye MP:0005391 9.32 CASP3 FASLG CCR7 IFNG IL10 ICAM1
Sources

Drugs & Therapeutics for Lymphadenitis

About this section

Drugs for Lymphadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 447043
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3 Anti-Inflammatory Agents Phase 4,Phase 3
4 Antineoplastic Agents, Hormonal Phase 4,Phase 3
5 glucocorticoids Phase 4,Phase 3
6 Hormone Antagonists Phase 4,Phase 3
7 Hormones Phase 4,Phase 3
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
9
Petrolatum Approved, Investigational Phase 3 8009-03-8
10
Silver sulfadiazine Approved, Vet_approved Phase 3 22199-08-2 441244
11
Sulfadiazine Approved, Investigational, Vet_approved Phase 3 68-35-9 5215
12
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
13
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
14
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
15
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
16 Anti-Infective Agents Phase 3,Not Applicable
17 Anti-Infective Agents, Local Phase 3
18 Antiparasitic Agents Phase 3
19 Antiprotozoal Agents Phase 3
20 Dermatologic Agents Phase 3
21 Emollients Phase 3
22 Anti-Bacterial Agents Phase 3
23 Amoxicillin-Potassium Clavulanate Combination Phase 3
24 beta-Lactamase Inhibitors Phase 3
25 Clavulanic Acid Phase 3
26 Gentamicins Phase 3
27 Antimalarials Phase 3
28 Antibiotics, Antitubercular Phase 3
29 Antiemetics Phase 3
30 Autonomic Agents Phase 3
31 Gastrointestinal Agents Phase 3
32 Methylprednisolone acetate Phase 3
33 Methylprednisolone Hemisuccinate Phase 3
34 Neuroprotective Agents Phase 3
35 Peripheral Nervous System Agents Phase 3
36 Prednisolone acetate Phase 3
37 Prednisolone hemisuccinate Phase 3
38 Prednisolone phosphate Phase 3
39 Protective Agents Phase 3
40 Antibodies Phase 1
41 Antibodies, Monoclonal Phase 1
42 Immunoglobulins Phase 1
43
Ethanol Approved Not Applicable 64-17-5 702
44
Formaldehyde Approved, Vet_approved Not Applicable 50-00-0 712
45 Disinfectants Not Applicable

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
2 A Trial Comparing the Efficacy and Safety of Open Dressing With Petrolatum Jelly vs. Standard Gauze Dressing With Silver Sulfadiazine Completed NCT02109718 Phase 3 Open Dressings with Petrolatum Jelly;Silver Sulfadiazine Gauze Dressing Group
3 Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis Recruiting NCT03132116 Phase 3 gentamicin;placebo
4 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka Recruiting NCT02929134 Phase 3 Doxycycline;Placebo
5 A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali Recruiting NCT02927496 Phase 3 Doxycycline;Placebo
6 Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone Recruiting NCT02281929 Phase 3 Amoxicillin;Placebo;Prednisolone
7 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India Not yet recruiting NCT02929121 Phase 3 Doxycycline;Placebo
8 Comparison of Antibiotic Therapy Alone or Combined With Corticosteroids for the Treatment of Nontuberculous Mycobacterial Cervicofacial Lymphadenitis in Children: A Randomized Double-Blind Placebo-Controlled Study Withdrawn NCT01614977 Phase 3 Methylprednisoline
9 Probiotics and Corticosteroids for Treating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) Withdrawn NCT02535962 Phase 2
10 Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Unknown status NCT02775994 Phase 1 Canakinumab
11 Linear Endosonography for the Assessment of Sarcoidosis Stage O Unknown status NCT01383226 Not Applicable
12 Ultrasonographic Differentiation Between Kikuchi's Disease and Lymphoma in Patients With Cervical Lymphadenopathy Unknown status NCT01310933
13 Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) Completed NCT01406275 Amoxicillin and clavulanate
14 Efficacy Study of Thrice Weekly Directly Observed Treatment Short-Course Regimen in Tubercular Pleural Effusion Completed NCT01560078
15 Diagnostic Accuracy of Polymerase Chain Reaction for Mycobacterium Tuberculosis Using EBUS-TBNA Samples Recruiting NCT02497079 Not Applicable
16 Tonsillotomy or Follow-up in PFAPA Syndrome Recruiting NCT03331497 Not Applicable
17 Explanations for Negative Laparoscopic Appendectomies and Normal Laparoscopies Recruiting NCT03349814
18 Study of Bcg Scars of Under Five Years Old Children in Assiut University Hospital Not yet recruiting NCT03548233 Not Applicable
19 Clinical Studies of Kikuchi's Disease Withdrawn NCT00172445 Not Applicable

Search NIH Clinical Center for Lymphadenitis

Cochrane evidence based reviews: lymphadenitis

Sources

Genetic Tests for Lymphadenitis

About this section
Sources

Anatomical Context for Lymphadenitis

About this section

MalaCards organs/tissues related to Lymphadenitis:

41
Lymph Node, Testes, Skin, T Cells, Thyroid, B Cells, Lung
Sources

Publications for Lymphadenitis

About this section

Articles related to Lymphadenitis:

(show top 50) (show all 864)
# Title Authors Year
1
Evaluation of loop mediated isothermal amplification (LAMP) assay in the diagnosis of tubercular lymphadenitis: A pilot study. ( 29332654 )
2018
2
Histiocytic necrotising lymphadenitis identical to Kikuchi-Fujimoto disease in CNS lupus. ( 29884722 )
2018
3
Multidrug-resistant Tuberculosis Lymphadenitis as the Initial Presentation of Secondary Multidrug-resistant Tuberculosis: A Case Report. ( 29805932 )
2018
4
Toxoplasmosis submandibular lymphadenitis: Report of an unusual case with a brief review. ( 29731568 )
2018
5
Lymphadenitis and Lymphadenopathy. ( 29131085 )
2018
6
Epitrochlear lymphadenitis mimicking subcutaneous abscess. ( 29444798 )
2018
7
Histological Comparison Of Two Staining Methods In Identification Of Mycobacterium Tuberculosis In Granulomatous Lymphadenitis. ( 29938410 )
2018
8
Human Herpes Virus 6 (HHV-6)-associated Lymphadenitis: Pitfalls in Diagnosis in Benign and Malignant Settings. ( 29975251 )
2018
9
Conservative treatment for cutaneous fistula resulted from abscess formation in patients with tuberculous cervical lymphadenitis. ( 29402607 )
2018
10
Diminished circulating plasma and elevated lymph node culture supernatant levels of IL-10 family cytokines in tuberculous lymphadenitis. ( 29871780 )
2018
11
Metastatic tubercular gummas and splenic tuberculoma secondary to tubercular lymphadenitis in an immunocompetent female. ( 29892975 )
2018
12
BCG-Induced Granulomatous Balanoposthitis and Lymphadenitis Unresponsive to Isoniazid Therapy: A Case Report and Review of theA Literature. ( 29463439 )
2018
13
Cervicofacial lymphadenitis due to<i>Mycobacterium mantenii:</i>rapid and reliable identification by MALDI-TOF MS. ( 29348923 )
2018
14
Association of Corynebacterium pseudotuberculosis recombinant proteins rCP09720 or rCP01850 with rPLD as immunogens in caseous lymphadenitis immunoprophylaxis. ( 29174312 )
2018
15
Leader gene of Corynebacterium pseudotuberculosis may be useful in vaccines against caseous lymphadenitis of goats: a bioinformatics approach. ( 29937460 )
2018
16
Purulent lymphadenitis caused by Staphylococcus argenteus, representing the first Japanese case of Staphylococcus argenteus (multilocus sequence type 2250) infection in a 12-year-old boy. ( 29709375 )
2018
17
Necrotizing lymphadenitis: If not tuberculosis then what? ( 29915771 )
2018
18
Severe Disseminated Necrotizing and Granulomatous Lymphadenitis and Encephalitis in a Dog Due to Sporotrichum pruinosum (Teleomorph: Phanerochaete chrysosporium). ( 29191132 )
2018
19
Minimally invasive approach to suppurated cervical lymphadenitis in children: Our experience on 60 patients. ( 29687954 )
2018
20
Image Gallery: Cervical lymphadenitis as an unusual presentation of disseminated coccidioidomycosis. ( 29897112 )
2018
21
Toxoplasma lymphadenitis caused by ingestion of raw blood and meat of deer in a 10-year-old boy. ( 29884335 )
2018
22
Unusual wound healing following suppurative BCG lymphadenitis. ( 29848543 )
2018
23
Severe bacterial sepsis results in delayed diagnosis of tuberculous lymphadenitis in a rheumatoid arthritis patient treated with adalimumab. ( 29862158 )
2018
24
Syphilitic lymphadenitis with abscess formation involving cervical lymph nodes. ( 29438971 )
2018
25
Kikuchi's disease (histiocytic necrotizing lymphadenitis): A rare presentation with acute kidney injury, peripheral neuropathy, and aseptic meningitis with cutaneous involvement. ( 29567898 )
2018
26
Mycobacterium lentiflavum as the main cause of lymphadenitis in pediatric population. ( 29395439 )
2018
27
Fine-needle aspiration cytology of leishmanial lymphadenitis in an HIV-reactive patient: Report of a rare case. ( 29930909 )
2018
28
Genotyping and molecular detection of multidrug-resistant <i>Mycobacterium tuberculosis</i> among tuberculosis lymphadenitis cases in Addis Ababa, Ethiopia. ( 29675262 )
2018
29
Lymphadenitis associated with cat-scratch disease simulating a neoplasm: Imaging findings with histopathological associations. ( 29399138 )
2018
30
Reactive Lymphoid Hyperplasia or Tubercular Lymphadenitis: Can Real-Time PCR on Fine-Needle Aspirates Help Physicians in Concluding the Diagnosis? ( 29763927 )
2018
31
Histiocytic Necrotizing Lymphadenitis Involving the Neck: Radiology-Pathology Correlation. ( 29858834 )
2018
32
Unusual case of cerebral demyelination and bilateral optic neuritis in an infant with suppurative BCG lymphadenitis. ( 29848532 )
2018
33
Concentration of fine needle aspirates similar to molecular method improves sensitivity of the diagnosis of tuberculous lymphadenitis in Addis Ababa, Ethiopia. ( 28088186 )
2017
34
Infantile incomplete Kawasaki disease mimicking cervical purulent lymphadenitis with coronary artery aneurysm. ( 28786205 )
2017
35
Villada G, Vega F. Clusters of paracortical plasmacytoid dendritic cells in lupus lymphadenitis. Blood. 2017;129(13):1884. ( 28596440 )
2017
36
Nine patients with chronic granulomatous disease having selective neck dissection for severe cervical lymphadenitis. ( 28727298 )
2017
37
Children with lymphadenitis associated with Bacillus Calmette-GuAcrin (BCG) vaccination do not experience more infections when compared with BCG-vaccinated children without lymphadenitis: a three years paired-cohort in Mexico. ( 29201375 )
2017
38
Clinical and cytological features in diagnosis of peripheral tubercular lymphadenitis - A hospital-based study from central India. ( 28941854 )
2017
39
An HIV-positive Case of Obstructive Jaundice Caused by Immune Reconstitution Inflammatory Syndrome of Tuberculous Lymphadenitis Successfully Treated with Corticosteroids. ( 28883243 )
2017
40
BCG vaccination-induced suppurative lymphadenitis: four signs to pay attention to. ( 28425207 )
2017
41
Mandibular Osteomyelitis and Cervical Lymphadenitis Due to Mycobacterium abscessus: Surgical Management of a Pediatric Cohort With a Shared Epidemiologic Exposure. ( 28938329 )
2017
42
Mesenteric lymphadenitis as a presenting feature of Whipple's disease. ( 28660130 )
2017
43
Clinicopathological features of cryptococcal lymphadenitis and a review of literature. ( 28592745 )
2017
44
A 38-year-old woman with necrotising cervical lymphadenitis due to Histoplasma capsulatum. ( 28822097 )
2017
45
The predominance of Ethiopian specific Mycobacterium tuberculosis families and minimal contribution of Mycobacterium bovis in tuberculous lymphadenitis patients in Southwest Ethiopia. ( 28919549 )
2017
46
Cytomorphological patterns of tubercular lymphadenitis and its comparison with Ziehl-Neelsen staining and culture in eastern up. (Gorakhpur region): Cytological study of 400 cases. ( 28701826 )
2017
47
A case of cervical radiculopathy due to tuberculosis cervical lymphadenitis. ( 29620071 )
2017
48
Comparison of Conventional Ziehl-Neelsen Method of Acid Fast Bacilli with Modified Bleach Method in Tuberculous Lymphadenitis. ( 29118472 )
2017
49
The diagnostic activity on wild animals through the description of a model case report (caseous lymphadenitis by<i>Corynebacterium pseudotuberculosis</i>associated with<i>Pasteurella</i>spp and parasites infection in an alpine ibex -<i>Capra ibex</i>). ( 29392118 )
2017
50
Acute Nonspecific Mesenteric Lymphadenitis: More Than &amp;quot;No Need for Surgery&amp;quot;. ( 28261620 )
2017
Sources

Variations for Lymphadenitis

About this section
Sources

Expression for Lymphadenitis

About this section
Search GEO for disease gene expression data for Lymphadenitis.
Sources

Pathways for Lymphadenitis

About this section

Pathways related to Lymphadenitis according to GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14.1 CASP3 CCL22 CD209 CXCL8 FASLG ICAM1
2
ERK Signaling 64
Show member pathways
 13.94 CASP3 CCL22 CCR7 CXCL8 CXCR3 FASLG
3
PEDF Induced Signaling 64
Show member pathways
 13.73 CASP3 CCL22 CCR7 CXCL8 CXCR3 FASLG
4
TGF-Beta Pathway 64
Show member pathways
 13.63 CCL22 CXCL8 IFNG IFNGR1 IL10 IL12RB1
5
Akt Signaling 64
Show member pathways
 13.54 CASP3 CCL22 CCR7 CXCL8 CXCR3 FASLG
6
PAK Pathway 64
Show member pathways
 13.44 CASP3 CCL22 CCR7 CXCL8 CXCR3 FASLG
7
Cytokine Signaling in Immune system 66
Show member pathways
 13.32 CASP3 CCL22 CXCL8 FASLG ICAM1 IFNG
8
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 13.13 CXCL8 FASLG IFNG IFNGR1 IL10 IL18
9
Allograft rejection 1 37
Show member pathways
 12.96 CASP3 CXCL8 FASLG ICAM1 IFNG IFNGR1
10
Pathways in cancer 37
12.93 CASP3 CXCL8 FASLG IFNG IFNGR1 IL12RB1
11
CCR5 Pathway in Macrophages 64
Show member pathways
 12.91 CCL22 CCR7 CXCL8 CXCR3 FASLG
12
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.87 CXCL8 IFNG IL18 IL1B TLR4 TNF
13
IL-2 Pathway 64
Show member pathways
 12.84 IFNG IFNGR1 IL1B TLR4 TNF
14
Influenza A 37
Show member pathways
 12.83 CASP3 CD209 CXCL8 FASLG ICAM1 IFNG
15
4-1BB Pathway 64
Show member pathways
 12.79 CASP3 FASLG IFNG IFNGR1 IL1B TNF
16
Regulation of IFNA signaling 66
Show member pathways
 12.77 CXCL8 IFNG IFNGR1 IL10 IL12RB1 IL18
17
Kaposi's sarcoma-associated herpesvirus infection 37
Show member pathways
 12.73 CASP3 CXCL8 FASLG ICAM1 IFNGR1 TLR4
18
Immune response IL-23 signaling pathway 22
Show member pathways
 12.72 IFNG IL10 IL12RB1 IL18 IL1B TNF
19
NF-kappaB Signaling 4
12.7 FASLG IFNG IL10 IL1B SOCS1 TNF
20
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.66 CASP3 FASLG ICAM1 IFNG IFNGR1 TNF
21
TRAF Pathway 64
Show member pathways
 12.65 CASP3 FASLG IL1B TLR4 TNF
22
Th17 cell differentiation 37
Show member pathways
 12.51 IFNG IFNGR1 IL10 IL12RB1 IL18 IL1B
23
T cell receptor signaling pathway 37
Show member pathways
 12.47 IFNG IL10 IL1B TNF
24
IL-17 Family Signaling Pathways 65
Show member pathways
 12.45 CASP3 CXCL8 IFNG IL1B TNF
25
Th1 Differentiation Pathway 65
Show member pathways
 12.44 IFNG IFNGR1 IL10 IL12RB1 IL18 IL1B
26
Toxoplasmosis 37
Show member pathways
 12.43 CASP3 IFNG IFNGR1 IL10 IL1B SOCS1
27
Toll Comparative Pathway 64
Show member pathways
 12.42 CXCL8 IFNG IFNGR1 IL1B TLR4 TNF
28
Folate Metabolism 1
Show member pathways
 12.39 ICAM1 IFNG IL1B TNF
29
Necroptosis 37
Show member pathways
 12.37 FASLG IFNG IFNGR1 IL1B TLR4 TNF
30
Bacterial infections in CF airways 22
Show member pathways
 12.37 CXCL8 FASLG IFNG IFNGR1 IL1B TLR4
31
Proteoglycans in cancer 37
12.36 CASP3 FASLG TLR4 TNF
32
C-type lectin receptor signaling pathway 37
Show member pathways
 12.35 CCL22 CD209 IL10 IL1B TNF
33
Colorectal Cancer Metastasis 64
12.33 CASP3 IFNG IFNGR1 TLR4 TNF
34
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.32 CASP3 CXCL8 IL10 IL1B TNF
35
IL-1 Family Signaling Pathways 65
Show member pathways
 12.29 CXCL8 IL18 IL1B TNF
36
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.26 CCL22 CXCL8 ICAM1 IFNG IFNGR1 IL10
37
Spinal Cord Injury 1
12.21 CASP3 CXCL8 ICAM1 IFNG IL1B TLR4
38
Osteoclast differentiation 37
12.2 IFNG IFNGR1 IL1B SOCS1 TNF
39
Fluid shear stress and atherosclerosis 37
12.18 ICAM1 IFNG IL1B TNF
40
IL12-mediated signaling events 1
Show member pathways
 12.17 FASLG IFNG IL12RB1 IL18 IL1B SOCS1
41
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
12.16 CCR7 CD209 IFNG IL10 TNF
42
TNF signaling pathway 37
12.12 CASP3 ICAM1 IL1B NOD2 TNF
43
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 65
Show member pathways
 12.1 CCL22 CCR7 CXCL8 CXCR3
44
AGE-RAGE signaling pathway in diabetic complications 37
12.08 CASP3 CXCL8 ICAM1 IL1B TNF
45
Amoebiasis 37
12.07 CASP3 CXCL8 IFNG IL10 IL1B TLR4
46
Jak-Stat Signaling Pathway 67
12.05 IFNG IFNGR1 IL10 IL12RB1 SOCS1
47
NF-kappa B signaling pathway 37
12.05 CXCL8 ICAM1 IL1B TLR4 TNF
48
Salmonella infection (KEGG) 37
12.03 CXCL8 IFNG IFNGR1 IL18 IL1B TLR4
49
Corticotropin-releasing hormone signaling pathway 1
12 CASP3 CXCL8 IL18 TLR4
50
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 12 CXCL8 ICAM1 IL12RB1 TLR4
Sources

GO Terms for Lymphadenitis

About this section

Cellular components related to Lymphadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 CCL22 CD209 CXCL8 FASLG IFNG IL10
2 extracellular space GO:0005615 9.81 CCL22 CXCL8 FASLG ICAM1 IFNG IL10
3 membrane raft GO:0045121 9.56 CASP3 FASLG ICAM1 TNF
4 cell surface GO:0009986 9.56 CCR7 CD209 CXCR3 FASLG ICAM1 NOD2
5 external side of plasma membrane GO:0009897 9.17 CCR7 CD209 CXCR3 FASLG ICAM1 TLR4
6 plasma membrane GO:0005886 10.15 CASP3 CCR7 CD209 CXCR3 FASLG ICAM1

Biological processes related to Lymphadenitis according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Name GO ID Score Top Affiliating Genes
1 chemotaxis GO:0006935 9.99 CCL22 CCR7 CXCL8 CXCR3
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 ICAM1 IL1B NOD2 TLR4 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.97 CXCL8 ICAM1 IL10 TLR4 TNF
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.97 CCR7 FASLG IL1B NOD2 TLR4 TNF
5 activation of MAPK activity GO:0000187 9.95 IL1B NOD2 TLR4 TNF
6 response to virus GO:0009615 9.95 CCL22 IFNG IFNGR1 TNF
7 cellular response to interferon-gamma GO:0071346 9.92 CCL22 ICAM1 IL12RB1
8 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.92 CASP3 FASLG TNF
9 apoptotic signaling pathway GO:0097190 9.92 CASP3 FASLG TLR4 TNF
10 regulation of inflammatory response GO:0050727 9.91 NOD2 TLR4 TNF
11 chemokine-mediated signaling pathway GO:0070098 9.91 CCL22 CCR7 CXCL8 CXCR3
12 cellular response to organic cyclic compound GO:0071407 9.91 CASP3 IL18 IL1B NOD2 TNF
13 cellular response to interleukin-1 GO:0071347 9.9 CCL22 CXCL8 ICAM1
14 interferon-gamma-mediated signaling pathway GO:0060333 9.9 ICAM1 IFNG IFNGR1
15 regulation of insulin secretion GO:0050796 9.9 IFNG IL1B TNF
16 neutrophil chemotaxis GO:0030593 9.89 CCL22 CXCL8 IL1B
17 response to glucocorticoid GO:0051384 9.89 CASP3 IL10 TNF
18 positive regulation of interleukin-6 production GO:0032755 9.88 IL1B NOD2 TLR4 TNF
19 positive regulation of JNK cascade GO:0046330 9.88 CCR7 IL1B NOD2 TLR4 TNF
20 interleukin-12-mediated signaling pathway GO:0035722 9.85 IFNG IL10 IL12RB1
21 regulation of cell adhesion GO:0030155 9.85 CXCL8 ICAM1 IL18
22 extrinsic apoptotic signaling pathway GO:0097191 9.85 FASLG IFNG TNF
23 cellular response to organic substance GO:0071310 9.84 CASP3 ICAM1 IL1B
24 positive regulation of phagocytosis GO:0050766 9.84 IL1B SLC11A1 TNF
25 lipopolysaccharide-mediated signaling pathway GO:0031663 9.84 IL18 IL1B TLR4 TNF
26 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.83 IL1B NOD2 TNF
27 positive regulation of interleukin-8 production GO:0032757 9.83 IL1B NOD2 TLR4 TNF
28 negative regulation of interleukin-6 production GO:0032715 9.82 IL10 TLR4 TNF
29 positive regulation of interleukin-12 production GO:0032735 9.81 CCR7 IFNG TLR4
30 response to lipopolysaccharide GO:0032496 9.81 CASP3 CCR7 CXCL8 FASLG ICAM1 IL10
31 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.8 IL18 IL1B NOD2 TLR4 TNF
32 positive regulation of interferon-gamma production GO:0032729 9.8 IL12RB1 IL18 IL1B SLC11A1 TLR4 TNF
33 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.78 IFNG IL1B TNF
34 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.77 IFNG IFNGR1 SOCS1
35 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.77 IL10 IL1B TNF
36 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 ICAM1 IFNG IL1B TLR4 TNF
37 response to molecule of bacterial origin GO:0002237 9.74 CXCL8 IL10
38 positive regulation of interleukin-17 production GO:0032740 9.74 IL18 NOD2
39 interferon-gamma production GO:0032609 9.74 IL18 TLR4
40 negative regulation of interleukin-17 production GO:0032700 9.74 IFNG TLR4
41 neutrophil activation GO:0042119 9.73 CXCL8 IL18
42 T-helper 1 type immune response GO:0042088 9.73 IL18 TLR4
43 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.73 IL18 IL1B
44 macrophage activation GO:0042116 9.73 SLC11A1 TLR4
45 positive regulation of dendritic cell antigen processing and presentation GO:0002606 9.73 CCR7 NOD2 SLC11A1
46 positive regulation of T-helper 1 type immune response GO:0002827 9.72 IL12RB1 SLC11A1
47 positive regulation of chemokine biosynthetic process GO:0045080 9.72 IL1B TNF
48 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.71 TLR4 TNF
49 endothelial cell apoptotic process GO:0072577 9.71 IL10 TNF
50 positive regulation of MHC class II biosynthetic process GO:0045348 9.71 IL10 TLR4

Molecular functions related to Lymphadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 CCL22 CXCL8 FASLG IFNG IL10 IL18
Sources

Sources for Lymphadenitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....