MCID: LYM021
MIFTS: 57

Lymphadenitis

Categories: Cardiovascular diseases, Endocrine diseases, Immune diseases, Skin diseases
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Aliases & Classifications for Lymphadenitis

MalaCards integrated aliases for Lymphadenitis:

Name: Lymphadenitis 11 43 14 71 75 33
Acute Lymphadenitis 11 71 31 33
Chronic Lymphadenitis 11 71 33
Chronic Adenitis 11 33
Chronic Adenitis of Any Lymph Node Except Mesenteric 33
Chronic Lymphadenitis Except Mesenteric 33
Chronic Non-Specific Lymphadenitis 33
Lymphatic Gland Inflammation 33
Inflammation of Lymph Node 11
Lymph Gland Inflammation 33
Inflammation of Gland 33
Acute Adenitis 11
Adenitis Nos 33
Polyadenitis 33
Adenitis 11

Classifications:



Summaries for Lymphadenitis

Disease Ontology: 11 A lymph node disease that is characterized by an acute or chronic inflammation of one or more lymph nodes.

MalaCards based summary: Lymphadenitis, also known as acute lymphadenitis, is related to cervical adenitis and filarial elephantiasis, and has symptoms including nausea and vomiting, abdominal pain and syncope. An important gene associated with Lymphadenitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are ERK Signaling and Disease. The drugs Azithromycin and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include lymph node, skin and salivary gland, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)

Related Diseases for Lymphadenitis

Diseases related to Lymphadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1046)
# Related Disease Score Top Affiliating Genes
1 cervical adenitis 32.6 TNF IL1B IFNG
2 filarial elephantiasis 32.1 TNF TLR4 IL10
3 axillary adenitis 32.0 IL12RB1 IFNGR1
4 chronic granulomatous disease 31.9 TNF IL1B IL12RB1 IFNG
5 familial mediterranean fever 31.6 TNF TLR4 NOD2 IL1B IL18 IL10
6 lymph node tuberculosis 31.2 TNF IFNG
7 toxoplasmosis 31.1 TNF TLR9 NOD2 IL1B IL10 IFNG
8 extrapulmonary tuberculosis 31.1 TNF SLC11A1 IL1B IL12RB1 IL10 IFNG
9 appendicitis 31.1 TNF TLR4 IL1B IL10 IFNG CXCL8
10 tularemia 31.0 TNF TLR4 SLC11A1 IL1B
11 exanthem 31.0 TNF IL1B IL18 IL10 IFNG CXCL8
12 macs syndrome 30.9 TNF SLC11A1 IL12RB1 IL10 IFNGR1 IFNG
13 aseptic meningitis 30.9 TNF IL1B IL10 CXCL8
14 cryptococcosis 30.9 TNF IL10 IFNG
15 cellulitis 30.9 TNF IL1B CXCL8
16 mycobacterium fortuitum 30.8 IL12RB1 IFNGR1
17 vasculitis 30.8 TNF IL1B IL10 ICAM1 CXCL8
18 ileitis 30.7 TNF TLR4 NOD2 IL10
19 human immunodeficiency virus type 1 30.7 IL10 IFNG CD209 CCR7
20 acquired immunodeficiency syndrome 30.7 TNF IL2RA IL1B IL10 IFNG ICAM1
21 multidrug-resistant tuberculosis 30.6 TNF IL10 IFNG
22 pyoderma 30.6 TNF NOD2 IL1B CXCL8
23 pharyngitis 30.6 TNF IL1B CXCL8
24 abdominal tuberculosis 30.6 TNF NOD2 IFNG
25 listeriosis 30.6 TNF IL1B IL18 IL10
26 thyroiditis 30.6 TNF IL1B IL10 IFNG FASLG
27 plague 30.6 TNF TLR4 IL1B IL10
28 miliary tuberculosis 30.6 TNF IL12RB1 IL10 IFNGR1 IFNG
29 anthracosis 30.6 TNF IL1B CXCL8
30 neutrophilic dermatosis, acute febrile 30.5 TNF IL1B CXCL8
31 aplastic anemia 30.5 TNF IL1B IL10 IFNG FASLG
32 cryptococcal meningitis 30.5 TNF IL10 IFNG
33 adult-onset still's disease 30.5 TNF IL1B IL18 FASLG
34 periodic fever, familial, autosomal dominant 30.5 TNF NOD2 IL1B IL18
35 chlamydia 30.5 TNF TLR4 IL1B IL18 IL10 IFNG
36 pulmonary tuberculosis 30.5 TNF TLR4 SLC11A1 IL2RA IL1B IL18
37 chickenpox 30.5 TNF IL1B IL10 IFNG
38 histoplasmosis 30.5 TNF IL12RB1 IFNG
39 juvenile rheumatoid arthritis 30.5 TNF SLC11A1 IL2RA IL1B IL18
40 purpura 30.5 TNF IL1B IL10 IFNG CXCL8
41 typhoid fever 30.5 TNF TLR4 SLC11A1 IL1B IFNGR1 IFNG
42 pleurisy 30.4 TNF IL1B IFNG CXCL8
43 pericarditis 30.4 TNF IL1B IFNG CXCL8
44 lymphopenia 30.4 IL2RA IL10 IFNG FASLG
45 myelitis 30.4 TNF IL10 CXCL8
46 leukemia, chronic lymphocytic 30.4 TNF TLR7 IL2RA IL10 CCR7 CASP3
47 intestinal tuberculosis 30.4 TNF NOD2 IFNG
48 mevalonic aciduria 30.4 TNF NOD2 IL1B IL18
49 coccidioidomycosis 30.4 TLR4 IL12RB1 IFNGR1
50 mixed connective tissue disease 30.4 TNF IL10 IFNG

Comorbidity relations with Lymphadenitis via Phenotypic Disease Network (PDN):


Prostate Cancer

Graphical network of the top 20 diseases related to Lymphadenitis:



Diseases related to Lymphadenitis

Symptoms & Phenotypes for Lymphadenitis

UMLS symptoms related to Lymphadenitis:


nausea and vomiting; abdominal pain; syncope; signs and symptoms of ill-defined conditions; (non-specific) malaise and fatigue; adenitis; fever of unknown origin

GenomeRNAi Phenotypes related to Lymphadenitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 10.2 CASP3 CXCL8 IL10 IL18 IL1B IL2RA
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 10.2 CASP3 CXCL8 FASLG ICAM1 IL10 IL18
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 10.2 ICAM1
4 no effect GR00402-S-1 10.13 CASP3 CCR7 CD209 CXCL8 CXCL9 FASLG
5 no effect GR00402-S-2 10.13 CASP3 CCR7 CD209 ICAM1 IFNG IFNGR1
6 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.46 CASP3 CXCL8 IL2RA TNF

MGI Mouse Phenotypes related to Lymphadenitis:

45 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.46 CASP3 CCR7 CD209 CXCL9 FASLG ICAM1
2 digestive/alimentary MP:0005381 10.38 CASP3 CCR7 CD209 FASLG ICAM1 IFNG
3 immune system MP:0005387 10.38 CASP3 CCR7 CD209 CXCL9 FASLG ICAM1
4 cellular MP:0005384 10.3 CASP3 CCR7 CD209 FASLG ICAM1 IFNG
5 neoplasm MP:0002006 10.25 FASLG ICAM1 IFNG IFNGR1 IL10 IL1B
6 endocrine/exocrine gland MP:0005379 10.24 CASP3 CCR7 FASLG ICAM1 IFNG IFNGR1
7 cardiovascular system MP:0005385 10.21 CASP3 FASLG ICAM1 IFNG IFNGR1 IL10
8 renal/urinary system MP:0005367 10.14 CASP3 CD209 FASLG IFNG IFNGR1 TLR4
9 muscle MP:0005369 10.13 CASP3 ICAM1 IFNG IL10 IL18 TLR4
10 hematopoietic system MP:0005397 10.13 CASP3 CCR7 CD209 CXCL9 FASLG ICAM1
11 vision/eye MP:0005391 10.03 CASP3 CCR7 FASLG ICAM1 IFNG IFNGR1
12 skeleton MP:0005390 10.02 CASP3 FASLG IFNG IFNGR1 IL10 IL1B
13 respiratory system MP:0005388 9.97 CASP3 FASLG IFNG IL10 IL2RA TLR4
14 mortality/aging MP:0010768 9.89 CASP3 CD209 CXCL9 FASLG ICAM1 IFNG
15 integument MP:0010771 9.4 CASP3 FASLG ICAM1 IFNG IFNGR1 IL10

Drugs & Therapeutics for Lymphadenitis

Drugs for Lymphadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 3 83905-01-5 447043
2 Anti-Infective Agents Phase 3
3 Gentamicins Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis: A Randomized Controlled Study Recruiting NCT03132116 Phase 3 gentamicin;placebo
2 Comparison of Antibiotic Therapy Alone or Combined With Corticosteroids for the Treatment of Nontuberculous Mycobacterial Cervicofacial Lymphadenitis in Children: A Randomized Double-Blind Placebo-Controlled Study Withdrawn NCT01614977 Phase 3 Methylprednisoline
3 Effects of Probiotic Addition to Corticosteroid Treatment for PFAPA Withdrawn NCT02535962 Phase 2
4 Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Unknown status NCT02775994 Phase 1 Canakinumab
5 CT Enlarged Mediastinal/Hilar Lymph Nodes Not Visible on Chest X-ray in the Non Cancer Patient : Diagnosis and Clinical Implications Using Endobronchial or Esophageal Ultrasound Controlled Needle Aspiration E(B)US-NA Unknown status NCT01383226
6 Ultrasonographic Differentiation Between Kikuchi's Disease and Lymphoma in Patients With Cervical Lymphadenopathy Unknown status NCT01310933
7 Immunology Dysregulation in Lymphadenitis Tuberculosis : An Observational Study Using Patient' Block Paraffins 2019 Until 2021 Completed NCT05202548
8 Evaluation of a Novel Axillary Lymph Node Ink Localization Technique: A Feasibility Study Recruiting NCT04136496
9 Clinical Studies of Kikuchi's Disease Withdrawn NCT00172445

Search NIH Clinical Center for Lymphadenitis

Cochrane evidence based reviews: lymphadenitis

Genetic Tests for Lymphadenitis

Anatomical Context for Lymphadenitis

Organs/tissues related to Lymphadenitis:

MalaCards : Lymph Node, Skin, Salivary Gland, Breast, T Cells, Thyroid, Bone Marrow

Publications for Lymphadenitis

Articles related to Lymphadenitis:

(show top 50) (show all 8126)
# Title Authors PMID Year
1
Primary syphilis presenting as a painful unilateral inguinal lymphadenopathy, without cutaneous manifestations, in a 71-year-old Japanese man: A case report. 62
36388614 2023
2
Immunoprophylactic properties of the Corynebacterium pseudotuberculosis-derived MBP:PLD:CP40 fusion protein. 62
36374330 2022
3
Disseminated histoplasmosis in an immunocompetent pediatric patient. 62
36445171 2022
4
Co-existence of atypical tuberculid with lupus vulgaris. 62
36461614 2022
5
Johne's disease in two Korean black goats (Capra hircus coreanae) with clinical and subclinical infection: A case report. 62
36426198 2022
6
Focused investigations to expedite cancer diagnosis among patients with lymphadenopathy in a tuberculosis- and HIV-endemic region. 62
36472201 2022
7
What is the optimal antibiotic therapy for the treatment of non-tuberculous mycobacterial lymphadenitis in children? 62
36270775 2022
8
Epidemiological characteristics and trends of Bacillus Calmette-Guérin lymphadenitis in Shanghai, China from 2010 to 2019. 62
34156902 2022
9
Tubercular lymphadenitis. 62
35917949 2022
10
Necrotizing herpes simplex lymphadenitis in a patient with chronic lymphocytic leukaemia/small lymphocytic lymphoma, clinically masquerading as Richter transformation. 62
35811089 2022
11
Tuberculous and non-tuberculous cervical lymphadenopathy incidence and distribution in Somalia from 2016 to 2020: A review of 241 cases. 62
36474662 2022
12
Two Distinct Cases of Adult-onset Kawasaki Disease. 62
35466164 2022
13
Aseptic meningitis in Kikuchi-Fujimoto Disease - Rare manifestation of a rare disease. 62
36281347 2022
14
The diagnostic and prognostic value of plasma circulating circNUP98 for nasopharyngeal carcinoma. 62
36330641 2022
15
Intussusception and COVID-19 in Children: A Systematic Review and Meta-Analysis. 62
36421194 2022
16
Does having MEFV gene sequence variants affect the clinical course and colchicine response in children with PFAPA syndrome? 62
36376520 2022
17
Fibrosing mediastinitis in a child with Mendelian susceptibility to mycobacterial disease possibly due to Bacillus Calmette-Guérin. 62
36397171 2022
18
Kikuchi lymphadenitis: A differential diagnosis of tuberculous cervical lymphadenitis. 62
36380612 2022
19
An Unusual Clinical Outcome and Surgical Intervention for Mediastinal Histoplasmosis. 62
36465220 2022
20
A Seven-Year-Old With Cervical Lymphadenitis and Multiple Animal Exposures. 62
36345070 2022
21
Clinicoepidemiologic considerations in the diagnosis of tuberculous lymphadenitis: evidence from a high burden country. 62
36167273 2022
22
Kikuchi-Fujimoto Disease and COVID-19 vaccination: pharmacovigilance approach. 62
36458479 2022
23
Kikuchi-Fujimoto disease following SARS-CoV-2 vaccination. 62
36414349 2022
24
A Seroepidemiological Survey of Corynebacterium pseudotuberculosis Infection in South Tyrol, Italy. 62
36365065 2022
25
First vaccination after birth: serious adverse events of Bacillus Calmette-Guérin (BCG) in real-world. 62
35687363 2022
26
Kikuchi-Fujimoto disease can present as delayed lymphadenopathy after COVID-19 vaccination. 62
35583472 2022
27
P22 protein complex in the serodiagnosis of animal tuberculosis: Antigenic stability and cross-reactivity with Corynebacterium pseudotuberculosis infection. 62
36265248 2022
28
Effect of heat-inactivated Mycobacterium avium subspecies paratuberculosis (MAP) vaccine on the lesions and immunopathology developed in target tissues of naturally MAP-infected goats. 62
36037619 2022
29
Uncommon defibrinogenation and coagulopathy caused by Trimeresurus stejnegeri stejnegeri envenomation in a patient with swelling above the ankle. 62
35987354 2022
30
Clinical, Microbiological Profile and Treatment Outcomes of Infants with BCG Adenitis: A Retrospective Study. 62
36370459 2022
31
Purulent lymphadenitis due to Halomonas hamiltonii: a case report. 62
36397607 2022
32
Incidence of lymphadenitis following Bacillus Calmette-Guérin (BCG) vaccination in north Indian children. 62
36460395 2022
33
All necrotizing nodes are not tuberculosis - A report of two cases. 62
36460410 2022
34
Delayed Diagnosis of Intestinal Tuberculosis: A Case Report. 62
36420228 2022
35
Prevalence of Castleman's disease in patients suffering from cervical lymphadenopathy. 62
36258858 2022
36
Ventricular septal defect with recurrent abdominal pain misdiagnosed as mesenteric lymphadenitis: A case report. 62
35589477 2022
37
Synchronous disease onset and flares in siblings with PFAPA. 62
36199113 2022
38
Accuracy of TB-PCR using endobronchial ultrasound guided trans-bronchial needle aspiration (EBUS-TBNA) samples in mediastinal granulomatous lymphadenopathy. 62
36460390 2022
39
Clinicopathologic Analysis of Kikuchi-Fujimoto Disease and Etiologic Exploration Using Metagenomic Next-Generation Sequencing. 62
36308713 2022
40
Chronic Granulomatous Disease: an Updated Experience, with Emphasis on Newly Recognized Features. 62
35696001 2022
41
Pyrazinamide related prolonged drug-induced liver injury: A case report. 62
36181061 2022
42
Morphologic Spectrum of Lymphadenopathy in Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome. 62
34902854 2022
43
Pathological study and molecular detection of zoonotic diseases in small ruminants at slaughterhouses in Mymensingh, Bangladesh. 62
36341049 2022
44
Incidence and Mortality of Extrapulmonary Tuberculosis in Ukraine: Analysis of National Surveillance Data. 62
34929028 2022
45
Two Cases of Kikuchi Disease Presenting with Aseptic Meningitis and Encephalitis. 62
35185045 2022
46
Chronic Leptin Deficiency Improves Tolerance of Physiological Damage and Host-Pathogen Cooperation during Yersinia pseudotuberculosis Infection. 62
35924898 2022
47
Study on the mechanism of Ginseng-Gegen for mesenteric lymphadenitis based on network pharmacology. 62
36247894 2022
48
Co-existent breast malignancy and contralateral primary axillary tuberculosis. 62
36101732 2022
49
Fine-needle aspiration of intramammary lymph nodes: a clinical, radiographic, and cytologic review. 62
36270911 2022
50
Herpes simplex virus lymphadenitis is associated with tumor reduction in a patient with chronic lymphocytic leukemia. 62
35862190 2022

Variations for Lymphadenitis

Expression for Lymphadenitis

Search GEO for disease gene expression data for Lymphadenitis.

Pathways for Lymphadenitis

Pathways related to Lymphadenitis according to GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 TNF IL2RA IL1B IL18 IL12RB1 IL10
2
Show member pathways
13.85 TLR9 TLR7 TLR4 NOD2 IL1B IL18
3
Show member pathways
13.76 CASP3 CD209 CXCL8 FASLG ICAM1 IFNG
4
Show member pathways
13.75 CASP3 CCR7 CXCL8 CXCL9 FASLG IFNG
5
Show member pathways
13.64 CXCL8 ICAM1 IFNG IFNGR1 IL10 IL12RB1
6
Show member pathways
13.54 TNF TLR9 TLR7 TLR4 IL2RA IL1B
7
Show member pathways
13.44 TNF IL2RA IL1B IL18 IL12RB1 IL10
8
Show member pathways
13.35 CASP3 CXCL8 FASLG ICAM1 IFNG IFNGR1
9
Show member pathways
13.31 TNF TLR9 TLR7 TLR4 IL2RA IL1B
10
Show member pathways
12.84 CASP3 CD209 CXCL8 CXCL9 FASLG IL1B
11
Show member pathways
12.79 CASP3 FASLG IFNG IFNGR1 IL1B TNF
12
Show member pathways
12.77 IL1B TLR4 TLR7 TLR9 TNF
13
Show member pathways
12.77 TNF TLR9 TLR7 TLR4 IL1B FASLG
14
Show member pathways
12.76 TNF IL2RA IL1B IL18 IL12RB1 IL10
15
Show member pathways
12.75 TNF TLR9 IL1B IL18 CXCL8 CD209
16
Show member pathways
12.74 TLR4 IL1B IL18 FASLG CASP3
17
Show member pathways
12.73 TNF IL1B IL18 IL12RB1 IL10 IFNG
18 12.73 TNF TLR9 TLR7 IL2RA IL1B IL10
19
Show member pathways
12.67 TNF TLR9 TLR7 TLR4 NOD2 IL1B
20
Show member pathways
12.46 TNF TLR4 IL1B IFNGR1 IFNG CXCL8
21
Show member pathways
12.46 TNF TLR9 TLR7 TLR4 IL1B IFNGR1
22 12.45 TNF IL1B FASLG CASP3
23 12.37 TNF TLR9 TLR7 TLR4 IFNGR1 IFNG
24 12.3 TNF IL1B IL10 CXCL8 CASP3
25
Show member pathways
12.26 CASP3 FASLG IL18 IL1B
26 12.24 TNF IL1B IL10 IFNGR1 IFNG
27
Show member pathways
12.23 TNF IL12RB1 IL10 IFNG
28 12.19 TNF IL2RA IL10 IFNG CD209 CCR7
29
Show member pathways
12.17 TLR9 TLR7 TLR4 IL2RA IL1B
30
Show member pathways
12.16 IL2RA IL1B IL18 IL12RB1 IFNG FASLG
31 12.15 TNF TLR4 IL1B IFNG ICAM1 CXCL8
32 12.1 CXCL8 FASLG ICAM1 IL10 IL18 IL1B
33
Show member pathways
12 TLR4 IL12RB1 ICAM1 CXCL8
34
Show member pathways
12 TLR9 TLR7 TLR4 IL1B IL12RB1 IFNG
35 11.99 CASP3 CXCL8 IL18 TLR4
36 11.96 CASP3 CXCL8 ICAM1 IL1B TLR4 TNF
37
Show member pathways
11.93 TNF IL1B IFNGR1 IFNG
38 11.93 TNF TLR7 TLR4 IL10 IFNG CCR7
39
Show member pathways
11.92 TLR9 TLR7 TLR4
40 11.92 TNF ICAM1 FASLG
41 11.92 TNF IL2RA IL1B IL18 IL12RB1 IL10
42 11.9 TLR4 IL10 IFNG CASP3
43
Show member pathways
11.89 TNF IL2RA IFNG FASLG CXCL8 CASP3
44 11.86 IL2RA IL1B IFNGR1 IFNG
45
Show member pathways
11.85 TNF IL1B IFNG ICAM1 CXCL8
46 11.85 TNF TLR7 TLR4 IL10 ICAM1 CXCL8
47 11.85 TNF TLR9 TLR7 IL1B IL10 IFNG
48 11.82 IFNG ICAM1 CXCL8
49 11.8 TNF TLR4 IL1B IL10
50 11.77 IL10 IFNG CXCL8

GO Terms for Lymphadenitis

Cellular components related to Lymphadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.8 TNF TLR4 NOD2 IL2RA ICAM1 FASLG
2 external side of plasma membrane GO:0009897 9.58 TNF TLR4 IL2RA IL12RB1 ICAM1 FASLG

Biological processes related to Lymphadenitis according to GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.68 TNF TLR9 TLR7 TLR4 SLC11A1 NOD2
2 signal transduction GO:0007165 10.56 CCR7 CXCL8 CXCL9 FASLG IFNG IFNGR1
3 positive regulation of gene expression GO:0010628 10.52 CXCL8 IFNG IFNGR1 IL18 IL1B SLC11A1
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.42 CCR7 ICAM1 NOD2 TLR4 TNF
5 defense response to bacterium GO:0042742 10.41 TNF TLR9 TLR4 SLC11A1 NOD2 IL10
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.41 IL18 IL1B NOD2 TLR4 TLR9 TNF
7 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.41 TNF TLR9 TLR4 NOD2 IL1B FASLG
8 positive regulation of tumor necrosis factor production GO:0032760 10.35 TLR9 TLR4 NOD2 IFNGR1 IFNG
9 inflammatory response GO:0006954 10.34 CCR7 CXCL8 CXCL9 IL18 IL1B IL2RA
10 positive regulation of JNK cascade GO:0046330 10.33 CCR7 IL1B NOD2 TLR4 TLR9 TNF
11 cellular response to type II interferon GO:0071346 10.32 TNF TLR4 IL12RB1 FASLG
12 JNK cascade GO:0007254 10.32 TNF TLR7 TLR4 NOD2 IL1B
13 positive regulation of inflammatory response GO:0050729 10.32 TNF TLR9 TLR7 TLR4 IL1B IL18
14 cellular response to lipopolysaccharide GO:0071222 10.31 TNF TLR9 TLR4 NOD2 IL1B IL10
15 positive regulation of MAP kinase activity GO:0043406 10.3 TNF TLR4 NOD2 IL1B
16 positive regulation of interleukin-6 production GO:0032755 10.3 IFNG IL1B NOD2 TLR4 TLR7 TLR9
17 positive regulation of interleukin-1 beta production GO:0032731 10.29 IFNG NOD2 TLR4 TNF
18 negative regulation of interleukin-6 production GO:0032715 10.29 TNF TLR9 TLR4 IL10
19 positive regulation of interleukin-8 production GO:0032757 10.29 IL1B NOD2 TLR4 TLR7 TLR9 TNF
20 defense response to Gram-positive bacterium GO:0050830 10.28 IL18 IL1B NOD2 TNF
21 response to virus GO:0009615 10.28 TNF TLR9 IFNGR1 IFNG
22 positive regulation of phagocytosis GO:0050766 10.28 TNF SLC11A1 NOD2 IL1B IFNG
23 MAPK cascade GO:0000165 10.27 IL18 IL1B NOD2 TLR7 TNF
24 positive regulation of interleukin-12 production GO:0032735 10.26 TLR9 TLR4 NOD2 IFNG CCR7
25 positive regulation of nitric oxide biosynthetic process GO:0045429 10.25 IFNG IL1B TLR4 TNF
26 cellular response to organic cyclic compound GO:0071407 10.25 TNF NOD2 IL1B IL18 CASP3
27 lipopolysaccharide-mediated signaling pathway GO:0031663 10.24 TNF TLR4 IL1B IL18
28 I-kappaB kinase/NF-kappaB signaling GO:0007249 10.24 TNF TLR9 TLR7 TLR4 NOD2 IL1B
29 regulation of insulin secretion GO:0050796 10.23 TNF IL1B IFNG
30 microglial cell activation GO:0001774 10.23 IFNG IFNGR1 TLR9 TNF
31 cellular response to amyloid-beta GO:1904646 10.22 TNF TLR4 ICAM1
32 negative regulation of type II interferon production GO:0032689 10.22 TLR4 NOD2 IL10
33 positive regulation of interleukin-10 production GO:0032733 10.22 NOD2 TLR4 TLR9
34 immune system process GO:0002376 10.22 TLR9 TLR7 TLR4 NOD2 IL2RA CD209
35 positive regulation of amyloid-beta formation GO:1902004 10.22 TNF IFNGR1 IFNG CASP3
36 positive regulation of cytokine production GO:0001819 10.22 TNF TLR9 SLC11A1 IL1B IL10 IFNG
37 positive regulation of interferon-beta production GO:0032728 10.21 TLR9 TLR7 TLR4
38 defense response GO:0006952 10.21 TNF NOD2 CXCL9 CXCL8
39 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 10.21 TLR9 TLR4 NOD2 IFNG
40 positive regulation of NIK/NF-kappaB signaling GO:1901224 10.21 TNF TLR9 TLR7 TLR4 NOD2 IL1B
41 positive regulation of activated T cell proliferation GO:0042104 10.19 IL2RA IL18 IL12RB1
42 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.19 TNF TLR4 NOD2
43 positive regulation of interferon-alpha production GO:0032727 10.19 TLR4 TLR7 TLR9
44 positive regulation of macrophage cytokine production GO:0060907 10.18 NOD2 TLR4 TLR7
45 toll-like receptor signaling pathway GO:0002224 10.18 TLR9 TLR7 TLR4
46 astrocyte activation GO:0048143 10.18 IFNG IFNGR1 IL1B TNF
47 negative regulation of interleukin-12 production GO:0032695 10.17 NOD2 IL10 CCR7
48 positive regulation of membrane protein ectodomain proteolysis GO:0051044 10.16 TNF IL1B IFNG
49 positive regulation of heterotypic cell-cell adhesion GO:0034116 10.16 TNF IL1B IL10
50 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 10.16 TLR9 IL1B IL18

Molecular functions related to Lymphadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.5 TNF IL1B IL18 IL10 IFNG FASLG
2 pattern recognition receptor activity GO:0038187 9.43 TLR9 TLR7 NOD2

Sources for Lymphadenitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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