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MCID: LYM021
MIFTS: 63

Lymphadenitis

Categories: Immune diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Lymphadenitis

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MalaCards integrated aliases for Lymphadenitis:

Name: Lymphadenitis 12 45 15 74
Chronic Lymphadenitis 12 74
Acute Lymphadenitis 12 74
Inflammation of Lymph Node 12
Chronic Adenitis 12
Acute Adenitis 12
Adenitis 12

Classifications:

MalaCards categories:
Anatomical: Skin diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:1602
ICD9CM 36 289.1 683
MeSH 45 D008199
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Summaries for Lymphadenitis

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MalaCards based summary : Lymphadenitis, also known as chronic lymphadenitis, is related to aphthous stomatitis and human immunodeficiency virus infectious disease, and has symptoms including nausea and vomiting, abdominal pain and syncope. An important gene associated with Lymphadenitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Prednisone and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include lymph node, testes and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 77 Lymphadenopathy or adenopathy is disease of the lymph nodes, in which they are abnormal in size or... more...

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Related Diseases for Lymphadenitis

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Diseases related to Lymphadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 517)
# Related Disease Score Top Affiliating Genes
1 aphthous stomatitis 31.8 IL10 IL1B TNF
2 human immunodeficiency virus infectious disease 30.8 IFNG IL10 TNF
3 appendicitis 30.6 CXCL8 IL10 IL1B TNF
4 hepatitis a 30.5 IFNG IL10 TNF
5 mixed connective tissue disease 30.5 IFNG IL10 TNF
6 adult-onset still's disease 30.4 IL18 IL1B TNF
7 pericarditis 30.3 IFNG IL1B TNF
8 familial mediterranean fever 30.3 IL1B NOD2 TNF
9 meningitis 30.3 CXCL8 IFNG IL10 IL1B TNF
10 toxoplasmosis 30.3 IFNG IL10 IL1B TLR4 TNF
11 ileitis 30.3 NOD2 TLR4 TNF
12 fasciitis 30.2 CXCL8 IL18 TNF
13 mycobacterium fortuitum 30.2 CXCL8 IFNGR1 IL12RB1
14 miliary tuberculosis 30.2 IFNG IL12RB1 TNF
15 myasthenia gravis 30.1 IFNG IL10 TNF
16 neuritis 30.1 IFNG IL1B TNF
17 cystitis 30.1 CXCL8 TLR4 TNF
18 aseptic meningitis 30.0 CXCL8 IFNG IL10 IL1B TNF
19 dermatitis 30.0 CCL22 IFNG IL18 NOD2
20 human immunodeficiency virus type 1 30.0 CCR7 CD209 IFNG IL10 TNF
21 melioidosis 30.0 IFNG IL10 IL18 TLR4 TNF
22 endocarditis 30.0 CXCL8 IL10 TNF
23 cutaneous lupus erythematosus 30.0 CXCR3 ICAM1 IL18 TNF
24 tonsillitis 29.9 CXCL8 IFNG IL1B TNF
25 pneumonia 29.9 CXCL8 IL10 IL1B TLR4 TNF
26 graft-versus-host disease 29.9 FASLG IFNG IL10 IL1B TNF
27 coccidioidomycosis 29.9 IFNGR1 IL10 TLR4
28 acquired immunodeficiency syndrome 29.9 IFNG IL10 IL1B IL2RA TNF
29 plasmodium falciparum malaria 29.8 ICAM1 IFNG IL10 IL18 TNF
30 haemophilus influenzae 29.8 CXCL8 IL1B TNF
31 cysticercosis 29.8 TLR4 IL1B IL18
32 schistosomiasis 29.8 IFNG IFNGR1 IL10 TNF
33 heart disease 29.7 CXCL8 ICAM1 IL10 IL1B TNF
34 osteomyelitis 29.7 CXCL8 IFNG IFNGR1 IL10 IL1B TNF
35 peritonitis 29.7 CXCL8 ICAM1 IL10 IL1B TNF
36 multidrug-resistant tuberculosis 29.7 TNF SLC11A1 IL10
37 chlamydia 29.7 CXCL8 IFNG IL10 IL1B TLR4 TNF
38 pleurisy 29.6 CXCL8 ICAM1 IFNG TNF
39 bacterial sepsis 29.6 CXCL8 IL10 TLR4 TNF
40 pulmonary tuberculosis 29.6 IFNG IFNGR1 IL10 IL12RB1 IL18 SLC11A1
41 erythema multiforme 29.6 CXCR3 FASLG ICAM1 IFNG TNF
42 bone inflammation disease 29.6 CXCL8 IFNG IL10 IL1B TNF
43 autoimmune disease 29.6 IFNG IL10 IL1B IL2RA TNF
44 synovitis 29.5 CXCL8 ICAM1 IL18 IL1B TNF
45 hemophagocytic lymphohistiocytosis 29.5 CXCL8 IFNG IL10 IL18 IL2RA TNF
46 toxic shock syndrome 29.5 CXCL8 IFNG IL10 IL1B TLR4 TNF
47 intermediate uveitis 29.5 CXCR3 IFNG IL10 IL2RA TNF
48 q fever 29.5 IFNG IL10 IL1B NOD2 TLR4 TNF
49 otitis media 29.5 CXCL8 IL10 IL1B TLR4 TNF
50 cutaneous leishmaniasis 29.4 IFNG IL10 SLC11A1 TLR4 TNF

Comorbidity relations with Lymphadenitis via Phenotypic Disease Network (PDN):


Prostate Cancer

Graphical network of the top 20 diseases related to Lymphadenitis:



Diseases related to Lymphadenitis
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Symptoms & Phenotypes for Lymphadenitis

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UMLS symptoms related to Lymphadenitis:


nausea and vomiting, abdominal pain, syncope, signs and symptoms of ill-defined conditions, (non-specific) malaise and fatigue, adenitis, fever of unknown origin

GenomeRNAi Phenotypes related to Lymphadenitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.89 CASP3 CXCL8 ICAM1 IL10 IL18 IL1B
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.89 CASP3 CXCL8 ICAM1 IL10 IL18 IL1B
3 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.26 CASP3 CXCL8 IL2RA TNF

MGI Mouse Phenotypes related to Lymphadenitis:

47 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.38 CASP3 CCR7 CXCR3 FASLG ICAM1 IFNG
2 immune system MP:0005387 10.36 CASP3 CCL22 CCR7 CXCR3 FASLG ICAM1
3 homeostasis/metabolism MP:0005376 10.33 CASP3 CCR7 CXCR3 FASLG ICAM1 IFNG
4 digestive/alimentary MP:0005381 10.32 CASP3 CCR7 FASLG ICAM1 IFNG IFNGR1
5 cellular MP:0005384 10.3 CASP3 CCR7 CXCR3 FASLG ICAM1 IFNG
6 cardiovascular system MP:0005385 10.28 CASP3 CXCR3 FASLG ICAM1 IFNG IFNGR1
7 mortality/aging MP:0010768 10.24 CASP3 CCL22 CXCR3 FASLG ICAM1 IFNG
8 endocrine/exocrine gland MP:0005379 10.15 CASP3 CCR7 FASLG ICAM1 IFNG IFNGR1
9 integument MP:0010771 10.1 CASP3 FASLG ICAM1 IFNG IFNGR1 IL10
10 neoplasm MP:0002006 10.02 CXCR3 FASLG ICAM1 IFNG IFNGR1 IL10
11 nervous system MP:0003631 10 CASP3 CCR7 FASLG ICAM1 IFNG IFNGR1
12 respiratory system MP:0005388 9.76 CASP3 CXCR3 FASLG IFNG IL10 IL2RA
13 skeleton MP:0005390 9.61 CASP3 FASLG IFNG IFNGR1 IL10 IL1B
14 vision/eye MP:0005391 9.32 CASP3 CCR7 FASLG ICAM1 IFNG IL10
Sources

Drugs & Therapeutics for Lymphadenitis

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Drugs for Lymphadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 447043
3 Anti-Inflammatory Agents Phase 4,Phase 3
4 Hormones Phase 4,Phase 3
5 Antineoplastic Agents, Hormonal Phase 4,Phase 3
6 Hormone Antagonists Phase 4,Phase 3
7 glucocorticoids Phase 4,Phase 3
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
9
Sulfadiazine Approved, Investigational, Vet_approved Phase 3 68-35-9 5215
10
Petrolatum Approved, Investigational Phase 3 8009-03-8
11
Silver sulfadiazine Approved, Vet_approved Phase 3 22199-08-2 441244
12
Clavulanate Approved, Vet_approved Phase 3 58001-44-8 5280980
13
Amoxicillin Approved, Vet_approved Phase 3,Phase 2 26787-78-0 33613
14
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
15
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
16
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
17
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
18
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
19
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
20 Anti-Infective Agents Phase 3,Phase 2,Not Applicable
21 Antiprotozoal Agents Phase 3
22 Dermatologic Agents Phase 3
23 Antiparasitic Agents Phase 3
24 Emollients Phase 3
25 Anti-Bacterial Agents Phase 3,Phase 2
26 Anti-Infective Agents, Local Phase 3
27 Amoxicillin-Potassium Clavulanate Combination Phase 3
28 beta-Lactamase Inhibitors Phase 3
29 Gentamicins Phase 3
30 Antimalarials Phase 3
31 Peripheral Nervous System Agents Phase 3
32 Prednisolone acetate Phase 3
33 Autonomic Agents Phase 3
34 Antibiotics, Antitubercular Phase 3
35 Antiemetics Phase 3
36 Methylprednisolone Acetate Phase 3
37 Gastrointestinal Agents Phase 3
38 Protective Agents Phase 3
39 Neuroprotective Agents Phase 3
40
Zinc Approved, Investigational Phase 2 7440-66-6 32051
41
Zinc oxide Approved Phase 2 1314-13-2
42
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
43 Calcium, Dietary Phase 2
44 Immunoglobulins Phase 1
45 Antibodies, Monoclonal Phase 1
46 Antibodies Phase 1
47 Immunologic Factors Phase 1,Not Applicable
48
Formaldehyde Approved, Vet_approved Not Applicable 50-00-0 712
49
Ethanol Approved Not Applicable 64-17-5 702
50
BCG vaccine Investigational Not Applicable

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
2 A Trial Comparing the Efficacy and Safety of Open Dressing With Petrolatum Jelly vs. Standard Gauze Dressing With Silver Sulfadiazine Completed NCT02109718 Phase 3 Open Dressings with Petrolatum Jelly;Silver Sulfadiazine Gauze Dressing Group
3 Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis Recruiting NCT03132116 Phase 3 gentamicin;placebo
4 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka Recruiting NCT02929134 Phase 3 Doxycycline;Placebo
5 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India Recruiting NCT02929121 Phase 3 Doxycycline;Placebo
6 A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali Recruiting NCT02927496 Phase 3 Doxycycline;Placebo
7 Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone Recruiting NCT02281929 Phase 3 Amoxicillin;Placebo;Prednisolone
8 Comparison of Antibiotic Therapy Alone or Combined With Corticosteroids for the Treatment of Nontuberculous Mycobacterial Cervicofacial Lymphadenitis in Children: A Randomized Double-Blind Placebo-Controlled Study Withdrawn NCT01614977 Phase 3 Methylprednisoline
9 Systemic and Local Antimicrobials in the Management of Dental Abscess in Children Recruiting NCT03761264 Phase 2 Odontopaste®;Pulpdent;Amoxicillin
10 Probiotics and Corticosteroids for Treating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) Withdrawn NCT02535962 Phase 2
11 Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Recruiting NCT02775994 Phase 1 Canakinumab
12 Linear Endosonography for the Assessment of Sarcoidosis Stage O Unknown status NCT01383226 Not Applicable
13 Diagnostic Accuracy of Polymerase Chain Reaction for Mycobacterium Tuberculosis Using EBUS-TBNA Samples Unknown status NCT02497079 Not Applicable
14 Ultrasonographic Differentiation Between Kikuchi's Disease and Lymphoma in Patients With Cervical Lymphadenopathy Unknown status NCT01310933
15 Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) Completed NCT01406275 Amoxicillin and clavulanate
16 Efficacy Study of Thrice Weekly Directly Observed Treatment Short-Course Regimen in Tubercular Pleural Effusion Completed NCT01560078
17 Tonsillotomy or Follow-up in PFAPA Syndrome Recruiting NCT03331497 Not Applicable
18 Explanations for Negative Laparoscopic Appendectomies and Normal Laparoscopies Recruiting NCT03349814
19 Study of Bcg Scars of Under Five Years Old Children in Assiut University Hospital Not yet recruiting NCT03548233 Not Applicable
20 Clinical Studies of Kikuchi's Disease Withdrawn NCT00172445 Not Applicable

Search NIH Clinical Center for Lymphadenitis

Cochrane evidence based reviews: lymphadenitis

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Genetic Tests for Lymphadenitis

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Anatomical Context for Lymphadenitis

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MalaCards organs/tissues related to Lymphadenitis:

42
Lymph Node, Testes, T Cells, Skin, Breast, Thyroid, B Cells
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Publications for Lymphadenitis

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Articles related to Lymphadenitis:

(show top 50) (show all 2044)
# Title Authors Year
1
Tuberculous lymphadenitis mimicking Castleman disease-like histological features. ( 30632056 )
2019
2
FDG-PET/CT findings, the vital clue to rare diagnosis of herpes simplex virus lymphadenitis simulating Richter transformation. ( 30471841 )
2019
3
Percutaneous ultrasound-guided laser ablation for the treatment of cervical tuberculous lymphadenitis: a pilot study. ( 30632441 )
2019
4
Canine sterile steroid-responsive lymphadenitis in 49 dogs. ( 30684356 )
2019
5
Pediatric acute unilateral suppurative lymphadenitis: The role of antibiotic susceptibilities at a large tertiary pediatric care center. ( 30743188 )
2019
6
50 Years Ago in The Journal of Pediatrics: Acute Mesenteric Lymphadenitis. ( 30798824 )
2019
7
Establishment of an objective endpoint in mice model for caseous lymphadenitis vaccine trials. ( 30827410 )
2019
8
Role of Mycobacterium avium lysate INF-γ, IL-17, and IL-2 ELISPOT assays in diagnosing nontuberculous mycobacteria lymphadenitis in children. ( 30834995 )
2019
9
A rare case of lymphadenitis and pulmonary disease caused by Mycobacterium paraffinicum. ( 30906560 )
2019
10
Chronic Neutropenia in Children With Abscess Forming Cervical Lymphadenitis Caused by Staphylococcus aureus. ( 29613972 )
2019
11
Recurrent Erythema Nodosum as a Warning of Tuberculous Lymphadenitis. ( 30611448 )
2019
12
Evaluation of loop mediated isothermal amplification (LAMP) assay in the diagnosis of tubercular lymphadenitis: A pilot study. ( 29332654 )
2018
13
Histiocytic necrotising lymphadenitis identical to Kikuchi-Fujimoto disease in CNS lupus. ( 29884722 )
2018
14
Multidrug-resistant Tuberculosis Lymphadenitis as the Initial Presentation of Secondary Multidrug-resistant Tuberculosis: A Case Report. ( 29805932 )
2018
15
Toxoplasmosis submandibular lymphadenitis: Report of an unusual case with a brief review. ( 29731568 )
2018
16
Lymphadenitis and Lymphadenopathy. ( 29131085 )
2018
17
Epitrochlear lymphadenitis mimicking subcutaneous abscess. ( 29444798 )
2018
18
Histological Comparison Of Two Staining Methods In Identification Of Mycobacterium Tuberculosis In Granulomatous Lymphadenitis. ( 29938410 )
2018
19
Human Herpes Virus 6 (HHV-6)-associated Lymphadenitis: Pitfalls in Diagnosis in Benign and Malignant Settings. ( 29975251 )
2018
20
Conservative treatment for cutaneous fistula resulted from abscess formation in patients with tuberculous cervical lymphadenitis. ( 29402607 )
2018
21
Diminished circulating plasma and elevated lymph node culture supernatant levels of IL-10 family cytokines in tuberculous lymphadenitis. ( 29871780 )
2018
22
Metastatic tubercular gummas and splenic tuberculoma secondary to tubercular lymphadenitis in an immunocompetent female. ( 29892975 )
2018
23
BCG-Induced Granulomatous Balanoposthitis and Lymphadenitis Unresponsive to Isoniazid Therapy: A Case Report and Review of theA Literature. ( 29463439 )
2018
24
Cervicofacial lymphadenitis due to<i>Mycobacterium mantenii:</i>rapid and reliable identification by MALDI-TOF MS. ( 29348923 )
2018
25
Association of Corynebacterium pseudotuberculosis recombinant proteins rCP09720 or rCP01850 with rPLD as immunogens in caseous lymphadenitis immunoprophylaxis. ( 29174312 )
2018
26
Leader gene of Corynebacterium pseudotuberculosis may be useful in vaccines against caseous lymphadenitis of goats: a bioinformatics approach. ( 29937460 )
2018
27
Purulent lymphadenitis caused by Staphylococcus argenteus, representing the first Japanese case of Staphylococcus argenteus (multilocus sequence type 2250) infection in a 12-year-old boy. ( 29709375 )
2018
28
Necrotizing lymphadenitis: If not tuberculosis then what? ( 29915771 )
2018
29
Severe Disseminated Necrotizing and Granulomatous Lymphadenitis and Encephalitis in a Dog Due to Sporotrichum pruinosum (Teleomorph: Phanerochaete chrysosporium). ( 29191132 )
2018
30
Minimally invasive approach to suppurated cervical lymphadenitis in children: Our experience on 60 patients. ( 29687954 )
2018
31
Image Gallery: Cervical lymphadenitis as an unusual presentation of disseminated coccidioidomycosis. ( 29897112 )
2018
32
Toxoplasma lymphadenitis caused by ingestion of raw blood and meat of deer in a 10-year-old boy. ( 29884335 )
2018
33
Unusual wound healing following suppurative BCG lymphadenitis. ( 29848543 )
2018
34
Severe bacterial sepsis results in delayed diagnosis of tuberculous lymphadenitis in a rheumatoid arthritis patient treated with adalimumab. ( 29862158 )
2018
35
Syphilitic lymphadenitis with abscess formation involving cervical lymph nodes. ( 29438971 )
2018
36
Kikuchi's disease (histiocytic necrotizing lymphadenitis): A rare presentation with acute kidney injury, peripheral neuropathy, and aseptic meningitis with cutaneous involvement. ( 29567898 )
2018
37
Mycobacterium lentiflavum as the main cause of lymphadenitis in pediatric population. ( 29395439 )
2018
38
Fine-needle aspiration cytology of leishmanial lymphadenitis in an HIV-reactive patient: Report of a rare case. ( 29930909 )
2018
39
Genotyping and molecular detection of multidrug-resistant <i>Mycobacterium tuberculosis</i> among tuberculosis lymphadenitis cases in Addis Ababa, Ethiopia. ( 29675262 )
2018
40
Lymphadenitis associated with cat-scratch disease simulating a neoplasm: Imaging findings with histopathological associations. ( 29399138 )
2018
41
Reactive Lymphoid Hyperplasia or Tubercular Lymphadenitis: Can Real-Time PCR on Fine-Needle Aspirates Help Physicians in Concluding the Diagnosis? ( 29763927 )
2018
42
Histiocytic Necrotizing Lymphadenitis Involving the Neck: Radiology-Pathology Correlation. ( 29858834 )
2018
43
Unusual case of cerebral demyelination and bilateral optic neuritis in an infant with suppurative BCG lymphadenitis. ( 29848532 )
2018
44
Noncaseating suppurative granulomatous lymphadenitis in adult onset Still's disease - a diagnostic dilemma in a tuberculosis-endemic region: a case report. ( 30318016 )
2018
45
A Case of Generalized, Superinfected Dermatitis and Inguinal Mycobacterium Lymphadenitis - TB or not TB? ( 30390733 )
2018
46
Imaging and Clinical Data Distinguish Lymphadenopathy-First-Presenting Kawasaki Disease from Bacterial Cervical Lymphadenitis. ( 30607392 )
2018
47
Three children of meningoencephalitis with Kikuchi necrotizing lymphadenitis. ( 29050838 )
2018
48
Cervical tuberculous lymphadenitis: diagnosis and demographics, a five-year case series in the UK. ( 29484929 )
2018
49
Ectopic Enterobius Vermicularis Infestation; An Extremely Rare Cause Of Mesenteric Lymphadenopathy Mimicking Tuberculous Lymphadenitis. ( 29504348 )
2018
50
Cervical Tuberculous Lymphadenitis. ( 29523421 )
2018
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Variations for Lymphadenitis

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Expression for Lymphadenitis

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Search GEO for disease gene expression data for Lymphadenitis.
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Pathways for Lymphadenitis

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Pathways related to Lymphadenitis according to GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 14.13 CASP3 CCL22 CD209 CXCL8 FASLG ICAM1
2
ERK Signaling 65
Show member pathways
 13.99 CASP3 CCL22 CCR7 CXCL8 CXCL9 CXCR3
3
PEDF Induced Signaling 65
Show member pathways
 13.72 CASP3 CCL22 CCR7 CXCL8 CXCL9 CXCR3
4
TGF-Beta Pathway 65
Show member pathways
 13.68 CCL22 CXCL8 ICAM1 IFNG IFNGR1 IL10
5
Akt Signaling 65
Show member pathways
 13.52 CASP3 CCL22 CCR7 CXCL8 CXCL9 CXCR3
6
PAK Pathway 65
Show member pathways
 13.43 CASP3 CCL22 CCR7 CXCL8 CXCL9 CXCR3
7
Cytokine Signaling in Immune system 67
Show member pathways
 13.39 CASP3 CCL22 CXCL8 FASLG ICAM1 IFNG
8
Toll-like Receptor Signaling Pathway 38 1
Show member pathways
 13.35 CXCL8 CXCL9 FASLG IFNG IFNGR1 IL10
9
Human cytomegalovirus infection 38
Show member pathways
 13.12 CASP3 CXCL8 FASLG ICAM1 IFNGR1 IL1B
10
CCR5 Pathway in Macrophages 65
Show member pathways
 12.99 CCL22 CCR7 CXCL8 CXCL9 CXCR3 FASLG
11
Pathways in cancer 38
12.99 CASP3 CXCL8 FASLG IFNG IFNGR1 IL12RB1
12
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 67
Show member pathways
 12.89 CXCL8 IFNG IL18 IL1B TLR4 TNF
13
4-1BB Pathway 65
Show member pathways
 12.81 CASP3 FASLG IFNG IFNGR1 IL1B TNF
14
Immune response NFAT in immune response 23
Show member pathways
 12.79 IFNG IFNGR1 IL10 IL12RB1 IL18 IL2RA
15
Immune response IL-23 signaling pathway 23
Show member pathways
 12.75 CXCL9 IFNG IL10 IL12RB1 IL18 IL1B
16
Th17 cell differentiation 38
Show member pathways
 12.73 IFNG IFNGR1 IL10 IL12RB1 IL18 IL1B
17
NF-kappaB Signaling 4
12.72 FASLG IFNG IL10 IL1B IL2RA TNF
18
Allograft rejection 1 38
Show member pathways
 12.71 CASP3 CXCL8 CXCL9 FASLG ICAM1 IFNG
19
TRAF Pathway 65
Show member pathways
 12.69 CASP3 FASLG IL1B TLR4 TNF
20
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 12.67 CASP3 FASLG ICAM1 IFNG IFNGR1 TNF
21
Influenza A 38
Show member pathways
 12.52 CASP3 CD209 CXCL8 FASLG ICAM1 IFNG
22
JAK-STAT signaling pathway (KEGG) 66
Show member pathways
 12.51 IFNG IFNGR1 IL10 IL12RB1 IL2RA
23
T cell receptor signaling pathway 38
Show member pathways
 12.48 IFNG IL10 IL1B TNF
24
Toll Comparative Pathway 65
Show member pathways
 12.48 CXCL8 IFNG IFNGR1 IL1B TLR4 TNF
25
IL-17 Family Signaling Pathways 66
Show member pathways
 12.47 CASP3 CXCL8 IFNG IL1B TNF
26
Toxoplasmosis 38
Show member pathways
 12.45 CASP3 IFNG IFNGR1 IL10 IL1B TLR4
27
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.43 CXCL8 IFNG IL10 IL18 IL1B IL2RA
28
Selenium Micronutrient Network 1
Show member pathways
 12.4 ICAM1 IFNG IL1B TNF
29
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 12.39 CCL22 CCR7 CXCL8 CXCL9 CXCR3 ICAM1
30
Bacterial infections in CF airways 23
Show member pathways
 12.39 CXCL8 FASLG IFNG IFNGR1 IL1B TLR4
31
Necroptosis 38
Show member pathways
 12.38 FASLG IFNG IFNGR1 IL1B TLR4 TNF
32
Proteoglycans in cancer 38
12.37 CASP3 FASLG TLR4 TNF
33
C-type lectin receptor signaling pathway 38
Show member pathways
 12.37 CCL22 CD209 IL10 IL1B TNF
34
Colorectal Cancer Metastasis 65
12.35 CASP3 IFNG IFNGR1 TLR4 TNF
35
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.34 CASP3 CXCL8 IL10 IL1B TNF
36
IL-1 Family Signaling Pathways 66
Show member pathways
 12.31 CXCL8 IL18 IL1B TNF
37
Immune response IFN gamma signaling pathway 23
Show member pathways
 12.26 CCL22 CXCL8 ICAM1 IFNG IFNGR1 IL10
38
Th1 Differentiation Pathway 66
Show member pathways
 12.23 IFNG IFNGR1 IL10 IL12RB1 IL18 IL1B
39
Spinal Cord Injury 1
12.21 CASP3 CXCL8 ICAM1 IFNG IL1B TLR4
40
Fluid shear stress and atherosclerosis 38
12.2 ICAM1 IFNG IL1B TNF
41
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
12.19 CCR7 CD209 IFNG IL10 IL2RA TNF
42
IL12-mediated signaling events 1
Show member pathways
 12.18 FASLG IFNG IL12RB1 IL18 IL1B IL2RA
43
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 66
Show member pathways
 12.17 CCL22 CCR7 CXCL8 CXCL9 CXCR3
44
Osteoclast differentiation 38
12.16 IFNG IFNGR1 IL1B TNF
45
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 12.15 IFNG IL1B TLR4 TNF
46
TNF signaling pathway 38
12.14 CASP3 ICAM1 IL1B NOD2 TNF
47
Interleukin-4 and 13 signaling 67
12.12 CCL22 CXCL8 FASLG ICAM1 IL10 IL18
48
AGE-RAGE signaling pathway in diabetic complications 38
12.09 CASP3 CXCL8 ICAM1 IL1B TNF
49
Amoebiasis 38
12.09 CASP3 CXCL8 IFNG IL10 IL1B TLR4
50
NF-kappa B signaling pathway 38
12.06 CXCL8 ICAM1 IL1B TLR4 TNF
Sources

GO Terms for Lymphadenitis

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Cellular components related to Lymphadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.96 CCL22 CD209 CXCL8 CXCL9 FASLG IFNG
2 extracellular space GO:0005615 9.85 CCL22 CXCL8 CXCL9 FASLG ICAM1 IFNG
3 membrane raft GO:0045121 9.62 CASP3 FASLG ICAM1 TNF
4 cell surface GO:0009986 9.61 CCR7 CD209 CXCR3 FASLG ICAM1 IL2RA
5 external side of plasma membrane GO:0009897 9.32 CCR7 CD209 CXCL9 CXCR3 FASLG ICAM1

Biological processes related to Lymphadenitis according to GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Name GO ID Score Top Affiliating Genes
1 defense response GO:0006952 9.99 CXCL8 CXCL9 NOD2 TNF
2 activation of MAPK activity GO:0000187 9.98 IL1B NOD2 TLR4 TNF
3 response to virus GO:0009615 9.98 CCL22 IFNG IFNGR1 TNF
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 ICAM1 IL18 IL1B NOD2 TLR4 TNF
5 cellular response to interferon-gamma GO:0071346 9.96 CCL22 ICAM1 IL12RB1 TLR4
6 positive regulation of JNK cascade GO:0046330 9.96 CCR7 IL1B NOD2 TLR4 TNF
7 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.94 CASP3 FASLG TNF
8 neutrophil chemotaxis GO:0030593 9.94 CCL22 CXCL8 CXCL9 IL1B
9 calcium-mediated signaling GO:0019722 9.93 CCR7 CXCL8 CXCR3
10 cell chemotaxis GO:0060326 9.93 CCL22 CCR7 CXCR3
11 cellular response to interleukin-1 GO:0071347 9.93 CCL22 CXCL8 ICAM1
12 chemokine-mediated signaling pathway GO:0070098 9.93 CCL22 CCR7 CXCL8 CXCL9 CXCR3
13 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.93 CCL22 CCR7 ICAM1 NOD2 TLR4 TNF
14 positive regulation of inflammatory response GO:0050729 9.92 IL18 TLR4 TNF
15 cellular response to organic cyclic compound GO:0071407 9.92 CASP3 IL18 IL1B NOD2 TNF
16 response to lipopolysaccharide GO:0032496 9.92 CASP3 CCR7 FASLG ICAM1 IL10 IL1B
17 interferon-gamma-mediated signaling pathway GO:0060333 9.91 ICAM1 IFNG IFNGR1
18 regulation of inflammatory response GO:0050727 9.91 NOD2 TLR4 TNF
19 regulation of insulin secretion GO:0050796 9.91 IFNG IL1B TNF
20 positive regulation of T cell proliferation GO:0042102 9.91 CD209 IL1B IL2RA
21 apoptotic signaling pathway GO:0097190 9.91 CASP3 FASLG TLR4 TNF
22 positive regulation of interleukin-6 production GO:0032755 9.91 IL1B NOD2 TLR4 TNF
23 inflammatory response GO:0006954 9.9 CCL22 CCR7 CXCL8 CXCL9 CXCR3 IL10
24 interleukin-12-mediated signaling pathway GO:0035722 9.88 IFNG IL10 IL12RB1
25 extrinsic apoptotic signaling pathway GO:0097191 9.88 FASLG IFNG TNF
26 cellular response to organic substance GO:0071310 9.88 CASP3 ICAM1 IL1B
27 regulation of cell adhesion GO:0030155 9.88 CXCL8 ICAM1 IL18
28 lipopolysaccharide-mediated signaling pathway GO:0031663 9.88 IL18 IL1B TLR4 TNF
29 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.88 IL18 IL1B NOD2 TLR4 TNF
30 positive regulation of interleukin-8 production GO:0032757 9.87 IL1B NOD2 TLR4 TNF
31 positive regulation of phagocytosis GO:0050766 9.86 IL1B SLC11A1 TNF
32 cellular response to lipopolysaccharide GO:0071222 9.86 CXCL8 CXCL9 ICAM1 IL10 IL1B NOD2
33 negative regulation of interleukin-6 production GO:0032715 9.85 IL10 TLR4 TNF
34 positive regulation of activated T cell proliferation GO:0042104 9.85 IL12RB1 IL18 IL2RA
35 positive regulation of interferon-gamma production GO:0032729 9.85 IL12RB1 IL18 IL1B SLC11A1 TLR4 TNF
36 positive regulation of interleukin-12 production GO:0032735 9.84 CCR7 IFNG TLR4
37 leukocyte chemotaxis GO:0030595 9.83 CXCL8 CXCL9 IL10
38 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 ICAM1 IFNG IL1B TLR4 TNF
39 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.8 IFNG IL1B TNF
40 response to glucocorticoid GO:0051384 9.8 CASP3 IL10 TNF
41 immune response GO:0006955 9.8 CCL22 CCR7 CXCL8 CXCL9 CXCR3 FASLG
42 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.79 IL10 IL1B TNF
43 positive regulation of dendritic cell antigen processing and presentation GO:0002606 9.77 CCR7 NOD2 SLC11A1
44 positive regulation of interleukin-17 production GO:0032740 9.76 IL18 NOD2
45 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.76 IFNG IFNGR1
46 interferon-gamma production GO:0032609 9.76 IL18 TLR4
47 negative regulation of interleukin-17 production GO:0032700 9.75 IFNG TLR4
48 response to molecule of bacterial origin GO:0002237 9.75 CXCL8 IL10
49 macrophage activation GO:0042116 9.75 SLC11A1 TLR4
50 neutrophil activation GO:0042119 9.75 CXCL8 IL18

Molecular functions related to Lymphadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 CCL22 CXCL8 CXCL9 FASLG IFNG IL10
2 chemokine activity GO:0008009 9.13 CCL22 CXCL8 CXCL9
Sources

Sources for Lymphadenitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
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33 HPO
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The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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