Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect
News and Views Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: LYM021
MIFTS: 55

Lymphadenitis

Categories: Immune diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Lymphadenitis

About this section

MalaCards integrated aliases for Lymphadenitis:

Name: Lymphadenitis 12 44 15 70
Acute Lymphadenitis 12 70 32
Chronic Lymphadenitis 12 70
Inflammation of Lymph Node 12
Chronic Adenitis 12
Acute Adenitis 12
Adenitis 12

Classifications:

MalaCards categories:
Anatomical: Skin diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1602
ICD9CM 34 289.1 683
MeSH 44 D008199
ICD10 32 I88.1 L04 L04.9
UMLS 70 C0024205 C0154304 C0157705
Sources

Summaries for Lymphadenitis

About this section
MalaCards based summary : Lymphadenitis, also known as acute lymphadenitis, is related to axillary adenitis and kawasaki disease, and has symptoms including nausea and vomiting, abdominal pain and syncope. An important gene associated with Lymphadenitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Azithromycin and Gentamicins have been mentioned in the context of this disorder. Affiliated tissues include lymph node, skin and thyroid, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Increased viability with MLN4924 (a NAE inhibitor)

Wikipedia : 73 Lymphadenopathy or adenopathy is a disease of the lymph nodes, in which they are abnormal in size or... more...

Sources

Related Diseases for Lymphadenitis

About this section

Diseases related to Lymphadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 945)
# Related Disease Score Top Affiliating Genes
1 axillary adenitis 32.2 IL12RB1 IFNGR1
2 kawasaki disease 31.9 TNF MYD88 IL1B IL18 IL10
3 chronic granulomatous disease 31.6 TNF SLC11A1 IL1B IL18 IFNG ICAM1
4 aphthous stomatitis 31.5 TNF TLR4 IL1B IL18 IL10 IFNG
5 extrapulmonary tuberculosis 31.0 SLC11A1 IL1B IL10 IFNGR1 IFNG CXCL9
6 appendicitis 31.0 TNF TLR4 IL1B IL10 IFNG CXCL8
7 pulmonary tuberculosis 31.0 TNF SLC11A1 IL18 IL12RB1 IL10 IFNGR1
8 toxoplasmosis 30.9 TNF TLR4 MYD88 IL1B IL10 IFNGR1
9 exanthem 30.9 TNF IL1B IL18 IL10 IFNG CXCL8
10 tularemia 30.9 TNF TLR4 SLC11A1 MYD88 IL1B
11 obstructive jaundice 30.9 TNF TLR4 CXCL8
12 mycobacterium fortuitum 30.8 IL12RB1 IFNGR1 CXCL8
13 neutropenia 30.8 TNF IL1B IL10 FASLG CXCL8
14 familial mediterranean fever 30.8 TNF TLR4 NOD2 IL1B IL18 IL10
15 cryptococcosis 30.8 TNF IL10 IFNG
16 aseptic meningitis 30.7 TNF IL1B IL10 IFNG CXCL8
17 acquired immunodeficiency syndrome 30.7 TNF IL1B IL10 IFNG ICAM1
18 syphilis 30.7 TNF IFNG FAS CD209
19 pharyngitis 30.7 TNF IL1B CXCL8
20 ileitis 30.7 TNF TLR4 NOD2
21 abdominal tuberculosis 30.6 TNF IL12RB1 IFNG
22 multidrug-resistant tuberculosis 30.6 TNF SLC11A1 IL10 IFNG
23 thyroiditis 30.6 TNF IL1B IL10 IFNG FASLG
24 pyoderma 30.6 TNF NOD2 IL1B CXCL8
25 miliary tuberculosis 30.6 TNF IL12RB1 IFNGR1 IFNG
26 anthracosis 30.6 TNF IL1B CXCL8
27 histoplasmosis 30.5 TNF IL12RB1 IFNG
28 chickenpox 30.5 TNF IL10 IFNG
29 purpura 30.5 TNF IL10 IFNG
30 lymphopenia 30.5 IL10 IFNG FASLG FAS
31 herpes zoster 30.5 TNF IL10 IFNG
32 encephalitis 30.5 TNF IL1B IL10 CXCL9 CD209
33 plague 30.5 TNF TLR4 MYD88 IL1B IL10
34 chlamydia 30.5 TNF TLR4 IL1B IL18 IL10 IFNG
35 meningitis 30.4 TNF TLR4 IL1B IL18 IL10 IFNG
36 ileus 30.4 TNF IL1B IL10
37 pericarditis 30.4 TNF IL1B IFNG CXCL8
38 coccidioidomycosis 30.4 TLR4 IL12RB1 IFNGR1
39 erythema nodosum 30.4 TNF NOD2 IL1B IL10 IFNG ICAM1
40 lymphoproliferative syndrome 30.4 IL10 FASLG FAS CCR7
41 mixed connective tissue disease 30.4 TNF IL10 IFNG
42 tonsillitis 30.4 TNF TLR4 IL1B IL10 IFNG CXCL8
43 leishmaniasis 30.4 TNF TLR4 SLC11A1 IL1B IL10 IFNGR1
44 intestinal tuberculosis 30.4 TNF NOD2 IFNG
45 filariasis 30.4 TNF TLR4 IL10 IFNG
46 connective tissue disease 30.4 TNF IL1B IL10 IFNG CXCL8
47 typhoid fever 30.4 TNF TLR4 SLC11A1 IL1B IFNGR1 IFNG
48 peritonitis 30.4 TNF TLR4 MYD88 IL1B IL18 IL10
49 actinomycosis 30.4 TNF IL1B IL10 CASP3
50 cyclic neutropenia 30.4 TNF IL1B IFNG CXCL8

Comorbidity relations with Lymphadenitis via Phenotypic Disease Network (PDN):


Prostate Cancer

Graphical network of the top 20 diseases related to Lymphadenitis:



Diseases related to Lymphadenitis
Sources

Symptoms & Phenotypes for Lymphadenitis

About this section

UMLS symptoms related to Lymphadenitis:


nausea and vomiting; abdominal pain; syncope; signs and symptoms of ill-defined conditions; (non-specific) malaise and fatigue; adenitis; fever of unknown origin

GenomeRNAi Phenotypes related to Lymphadenitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 ICAM1 NOD2
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 CASP3 FAS FASLG IL10 IL18 IL1B
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.6 CASP3 CXCL8 FAS IL10 IL18 IL1B
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.6 CASP3 CXCL8 FAS ICAM1 IL10 IL18
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.6 ICAM1

MGI Mouse Phenotypes related to Lymphadenitis:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.48 CASP3 CCR7 CD209 CXCR3 FAS FASLG
2 homeostasis/metabolism MP:0005376 10.44 CASP3 CCR7 CD209 CXCR3 FAS FASLG
3 immune system MP:0005387 10.42 CASP3 CCR7 CXCR3 FAS FASLG ICAM1
4 cellular MP:0005384 10.4 CASP3 CCR7 CXCR3 FAS FASLG ICAM1
5 digestive/alimentary MP:0005381 10.39 CASP3 CCR7 FAS FASLG ICAM1 IFNG
6 cardiovascular system MP:0005385 10.38 CASP3 CXCR3 FAS FASLG ICAM1 IFNG
7 mortality/aging MP:0010768 10.31 CASP3 CXCR3 FAS FASLG ICAM1 IFNG
8 integument MP:0010771 10.29 CASP3 FAS FASLG ICAM1 IFNG IFNGR1
9 endocrine/exocrine gland MP:0005379 10.24 CASP3 CCR7 FAS FASLG ICAM1 IFNG
10 neoplasm MP:0002006 10.15 CXCR3 FAS FASLG ICAM1 IFNG IFNGR1
11 nervous system MP:0003631 10.13 CASP3 CCR7 FAS FASLG ICAM1 IFNG
12 liver/biliary system MP:0005370 10.06 FAS FASLG IFNG IFNGR1 IL10 MYD88
13 muscle MP:0005369 10.01 CASP3 FAS ICAM1 IFNG IL10 IL18
14 renal/urinary system MP:0005367 9.86 CASP3 CXCR3 FAS FASLG IFNG IFNGR1
15 respiratory system MP:0005388 9.81 CASP3 CXCR3 FAS FASLG IFNG IL10
16 skeleton MP:0005390 9.73 CASP3 FAS FASLG IFNG IFNGR1 IL10
17 vision/eye MP:0005391 9.36 CASP3 CCR7 FAS FASLG ICAM1 IFNG
Sources

Drugs & Therapeutics for Lymphadenitis

About this section

Drugs for Lymphadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 3 83905-01-5 55185 447043
2 Gentamicins Phase 3
3 Anti-Infective Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis: A Randomized Controlled Study Recruiting NCT03132116 Phase 3 gentamicin;placebo
2 Comparison of Antibiotic Therapy Alone or Combined With Corticosteroids for the Treatment of Nontuberculous Mycobacterial Cervicofacial Lymphadenitis in Children: A Randomized Double-Blind Placebo-Controlled Study Withdrawn NCT01614977 Phase 3 Methylprednisoline
3 Effects of Probiotic Addition to Corticosteroid Treatment for PFAPA Withdrawn NCT02535962 Phase 2
4 Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Unknown status NCT02775994 Phase 1 Canakinumab
5 CT Enlarged Mediastinal/Hilar Lymph Nodes Not Visible on Chest X-ray in the Non Cancer Patient : Diagnosis and Clinical Implications Using Endobronchial or Esophageal Ultrasound Controlled Needle Aspiration E(B)US-NA Unknown status NCT01383226
6 Ultrasonographic Differentiation Between Kikuchi's Disease and Lymphoma in Patients With Cervical Lymphadenopathy Unknown status NCT01310933
7 Evaluation of a Novel Axillary Lymph Node Ink Localization Technique: A Feasibility Study Recruiting NCT04136496
8 Clinical Studies of Kikuchi's Disease Withdrawn NCT00172445

Search NIH Clinical Center for Lymphadenitis

Cochrane evidence based reviews: lymphadenitis

Sources

Genetic Tests for Lymphadenitis

About this section
Sources

Anatomical Context for Lymphadenitis

About this section

MalaCards organs/tissues related to Lymphadenitis:

40
Lymph Node, Skin, Thyroid, Breast, Liver, Bone, Kidney
Sources

Publications for Lymphadenitis

About this section

Articles related to Lymphadenitis:

(show top 50) (show all 6337)
# Title Authors PMID Year
1
Necrotizing lymphadenitis : A case report and literature review. 61
33241524 2021
2
Angioimmunoblastic T-cell lymphoma masquerading as granulomatous lymphadenitis: Fine needle aspiration cytology, clinical and radiology correlation. 61
33629798 2021
3
A review on the interactions between dendritic cells, filarial parasite and parasite-derived molecules in regulating the host immune responses. 61
33247468 2021
4
Diagnosis of nontuberculous mycobacterial lymphadenitis: the role of fine-needle aspiration. 61
33205252 2021
5
Histopathological Characterization of Cases of Spontaneous Fatal Feline Severe Fever with Thrombocytopenia Syndrome, Japan. 61
33754983 2021
6
Recurrent tracheal tumor with a critical airway requiring 'Y' stent - unique presentation of tuberculosis. 61
33794588 2021
7
Host biomarkers for monitoring therapeutic response in extrapulmonary tuberculosis. 61
33799008 2021
8
Usefulness of lactate dehydrogenase in differentiating abnormal cervical lymphadenopathy. 61
33717779 2021
9
Kikuchi-Fujimoto Disease Triggered by Systemic Lupus Erythematosus and Mycoplasma pneumoniae Infection-A Report of a Case and a Review of the Literature. 61
32809980 2021
10
Performance of cytology, acid-fast bacilli smear, gene Xpert and mycobacterial cultures in endobronchial ultrasound-transbronchial needle aspiration aspirate in diagnosing mediastinal tuberculous lymphadenitis. 61
33687004 2021
11
Surgical Experience of Video-Assisted Mediastinoscopy for Nonlung Cancer Diseases. 61
32634834 2021
12
Central Nervous System Vasculitis Due to an Endemic Zoonosis in Turkey; Tularemia. 61
33795957 2021
13
Development of Kikuchi-Fujimoto disease after a cervical lymph node metastasis of mucoepidermoid carcinoma: a case report. 61
32856133 2021
14
Analyses of tularemia cases and their long-term results. 61
33797535 2021
15
In vitro antimycobacterial studies of flavonols from Bauhinia vahlii Wight and Arn. 61
33614388 2021
16
Mycobacterium marseillense lymphadenitis: A newly identified strain in the pediatric population. 61
33798729 2021
17
Vaccines for caseous lymphadenitis: up-to-date and forward-looking strategies. 61
33651132 2021
18
Bacteriological, cytological, and molecular investigation of Corynebacterium pseudotuberculosis, mycobacteria, and other bacteria in caseous lymphadenitis and healthy lymph nodes of slaughtered sheep. 61
33185852 2021
19
PET-CT SCAN TO DIAGNOSE AND DEMONSTRATE RESOLUTION OF LUPUS LYMPHADENITIS WITH BELIMUMAB. 61
33693531 2021
20
Distinguishing lupus lymphadenitis from Kikuchi disease based on clinicopathological features and C4d immunohistochemistry. 61
33169134 2021
21
Bartonella henselae IgM seropositivity in both adult and pediatric patients with diverse clinical conditions in Turkey. 61
33661136 2021
22
Evidence for the medicinal value of Squama Manitis (pangolin scale): A systematic review. 61
32837905 2021
23
Cutaneous Kikuchi disease-like inflammatory pattern without lymph node involvement is associated with systemic disease and severe features in lupus erythematous: A case-control study. 61
33292039 2021
24
Positron-emission-tomography in tubercular lymphadenopathy: A study on its role in evaluating post-treatment response. 61
33642491 2021
25
Hemophagocytic Lymphohistiocytosis Associated with Histiocytic Necrotizing Lymphadenitis: A Clinical Study of 13 Children and Literature Review. 61
32956695 2021
26
Systemic coccidioidomycosis in a llama cria native to Missouri. 61
33583365 2021
27
Factors Affecting Cervical Lymph Node Suppuration in Oropharyngeal Tularemia Cases. 61
33645188 2021
28
The Transcriptional Regulatory Network of Corynebacterium pseudotuberculosis. 61
33671149 2021
29
Characterization of Plasmacytoid Dendritic Cells, Microbial Sequences, and Identification of a Candidate Public T-Cell Clone in Kikuchi-Fujimoto Disease. 61
33530869 2021
30
A novel approach for an immunogen against Corynebacterium pseudotuberculosis infection: An Escherichia coli bacterin expressing phospholipase D. 61
33485993 2021
31
Fine-needle aspiration cytology of Bacille Calmette-Guerin adenitis: A perplexing distinct clinical entity. 61
32918799 2021
32
An immunocompetent female with Mycobacterium abscessus cervical lymphadenitis mimicking malignancy. 61
33601034 2021
33
Altered plasma levels of βC and γC chain cytokines and post-treatment modulation in tuberculous lymphadenitis. 61
33341600 2021
34
Necrotising lymphadenitis resembling Kikuchi-Fujimoto disease in a patient receiving treatment with risankizumab. 61
32808283 2021
35
The rare multidrug cervical tubercular lymphadenitis in an infant from Iran: A case report and literature review. 61
33598225 2021
36
Recurrent lymphadenitis in a female XIAP/BIRC4 mutation carrier with normal lyonization. 61
33212241 2021
37
Clinical performance of Xpert MTB/RIF on contrast-enhanced ultrasound-guided core biopsy specimens for rapid diagnosis of superficial tuberculous lymphadenitis in high TB burden settings. 61
33543403 2021
38
Long-term outcome of nonsurgical treatment of nontuberculous mycobacterial cervicofacial lymphadenitis in children. 61
33358987 2021
39
Clinical and Immunological Characteristics of 63 Patients with Chronic Granulomatous Disease: Hacettepe Experience. 61
33629196 2021
40
Identification of Cytochrome b-245, beta-chain gene mutations, and clinical presentations in Iranian patients with X-linked chronic granulomatous disease. 61
33098164 2021
41
Interventions for bacterial folliculitis and boils (furuncles and carbuncles). 61
33634465 2021
42
A Novel Presentation of Tuberculosis with Intestinal Perforation in a Free-Ranging Australian Sea Lion (Neophoca cinerea). 61
33635989 2021
43
A Case of Nasopharyngeal Tuberculosis with Cervical Lymph Node Tuberculosis Suspected of Cervical Malignant Disease at the First Examination. 61
33572824 2021
44
Drug Resistance Conferring Mutation and Genetic Diversity of Mycobacterium tuberculosis Isolates in Tuberculosis Lymphadenitis Patients; Ethiopia. 61
33623398 2021
45
Diagnostic utility of medical thoracoscopy in T cell lymphoblastic lymphoma presenting with pleural effusion. 61
33425676 2021
46
Coinfection by Talaromyces marneffei and Mycobacterium abscessus in a human immunodeficiency virus-negative patient with anti-interferon-γ autoantibody: a case report. 61
33435770 2021
47
Diagnostic yield of endoscopic ultrasound-guided fine-needle aspiration of tubercular lymphadenitis using combination of cytology and Gene Xpert Mycobacterium tuberculosis/rifampicin (MTB/RIF) genes. 61
33443639 2021
48
Invasive Bacterial Infections in Afebrile Infants Diagnosed With Acute Otitis Media. 61
33288730 2021
49
Case report: Delayed retinoblastoma relapse in a lymph node after 9 years of complete remission. 61
33618927 2021
50
Comparative Proteomic Analyses Between Biofilm-Forming and Non-biofilm-Forming Strains of Corynebacterium pseudotuberculosis Isolated From Goats. 61
33665217 2021
Sources

Variations for Lymphadenitis

About this section
Sources

Expression for Lymphadenitis

About this section
Search GEO for disease gene expression data for Lymphadenitis.
Sources

Pathways for Lymphadenitis

About this section

Pathways related to Lymphadenitis according to GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.15 TNF TLR4 SLC11A1 NOD2 MYD88 IL1B
2
ERK Signaling 63
Show member pathways
 13.97 TNF IL1B IL18 IL12RB1 IL10 FASLG
3
PEDF Induced Signaling 63
Show member pathways
 13.75 TNF TLR4 IL1B IL18 IL12RB1 IL10
4
TGF-Beta Pathway 63
Show member pathways
 13.65 TNF IL1B IL18 IL12RB1 IL10 IFNGR1
5
PAK Pathway 63
Show member pathways
 13.45 TNF IL1B IL18 IL12RB1 IL10 FASLG
6
Akt Signaling 63
Show member pathways
 13.45 TNF TLR4 MYD88 IL1B IL18 IL12RB1
7
Cytokine Signaling in Immune system 65
Show member pathways
 13.43 TNF NOD2 MYD88 IL1B IL18 IL12RB1
8
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.16 TNF TLR4 MYD88 IL1B IL18 IL10
9
Human cytomegalovirus infection 36
Show member pathways
 13.12 TNF TLR4 MYD88 IL1B IFNGR1 ICAM1
10
Allograft rejection 36 1
Show member pathways
 13.01 TNF IL1B IL10 IFNG ICAM1 FASLG
11
Pathways in cancer 36
13 IL12RB1 IFNGR1 IFNG FASLG FAS CXCL8
12
CCR5 Pathway in Macrophages 63
Show member pathways
 12.99 FASLG FAS CXCR3 CXCL9 CXCL8 CCR7
13
Herpes simplex virus 1 infection 36
12.98 TNF MYD88 IL1B IFNGR1 IFNG FASLG
14
Salmonella infection (KEGG) 36
Show member pathways
 12.93 TNF TLR4 MYD88 IL1B IL18 FASLG
15
IL-2 Pathway 63
Show member pathways
 12.91 TNF TLR4 MYD88 IL1B IFNGR1 IFNG
16
MAPK signaling pathway 36 1
12.9 TNF MYD88 IL1B FASLG FAS CASP3
17
4-1BB Pathway 63
Show member pathways
 12.84 TNF IL1B IFNGR1 IFNG FASLG FAS
18
RANK Signaling in Osteoclasts 63
Show member pathways
 12.8 TNF IL1B IL10 IFNGR1 IFNG ICAM1
19
Apoptosis Modulation and Signaling 1
Show member pathways
 12.79 TNF MYD88 FASLG FAS CASP3
20
T cell receptor signaling pathway 36
Show member pathways
 12.79 TNF TLR4 MYD88 IL1B IL10 IFNGR1
21
Immune response NFAT in immune response 23
Show member pathways
 12.78 TNF IL18 IL12RB1 IL10 IFNGR1 IFNG
22
Immune response IL-23 signaling pathway 23
Show member pathways
 12.77 TNF IL1B IL18 IL12RB1 IL10 IFNG
23
TRAF Pathway 63
Show member pathways
 12.77 TNF TLR4 MYD88 IL1B FASLG FAS
24
Th17 cell differentiation 36
Show member pathways
 12.77 TNF TLR4 NOD2 IL1B IL18 IL12RB1
25
NF-kappaB Signaling 4
12.75 TNF MYD88 IL1B IL10 IFNG FASLG
26
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 12.7 TNF IFNGR1 IFNG ICAM1 FASLG FAS
27
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.62 TNF TLR4 NOD2 MYD88 IL1B IL18
28
Shigellosis 36
12.59 TNF TLR4 MYD88 IL1B IL18 CXCL8
29
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.54 TNF IL18 IL10 CXCR3 CXCL9 CXCL8
30
Toll Comparative Pathway 63
Show member pathways
 12.52 TNF TLR4 MYD88 IL1B IFNGR1 IFNG
31
JAK-STAT signaling pathway 36
Show member pathways
 12.48 IL12RB1 IL10 IFNGR1 IFNG
32
IL-17 Family Signaling Pathways 64
Show member pathways
 12.48 TNF IL1B IFNG CXCL8 CASP3
33
Proteoglycans in cancer 36
12.45 TNF TLR4 FASLG FAS CASP3
34
NOD-like receptor signaling pathway 36
12.44 TNF TLR4 NOD2 MYD88 IL1B IL18
35
Toxoplasmosis 36
Show member pathways
 12.43 TNF TLR4 MYD88 IL1B IL10 IFNGR1
36
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.42 TNF IL1B IL18 IL10 IFNG CXCL8
37
Selenium Micronutrient Network 1
Show member pathways
 12.41 TNF IL1B IFNG ICAM1
38
Necroptosis 36
Show member pathways
 12.41 TNF TLR4 IL1B IFNGR1 IFNG FASLG
39
Dimerization of procaspase-8 65
Show member pathways
 12.38 TLR4 FASLG FAS CASP3
40
IL-1 Family Signaling Pathways 64
Show member pathways
 12.38 TNF MYD88 IL1B IL18 CXCL8
41
C-type lectin receptor signaling pathway 36
Show member pathways
 12.37 TNF MYD88 IL1B IL10 CD209
42
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.35 TNF TLR4 MYD88 CXCL8
43
Colorectal Cancer Metastasis 63
12.35 TNF TLR4 IFNGR1 IFNG CASP3
44
Apoptosis and Autophagy 4
12.34 TNF FASLG FAS CASP3
45
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.34 TNF IL1B IL10 CXCL8 CASP3
46
Apoptosis and survival Caspase cascade 23
Show member pathways
 12.32 TNF FASLG FAS CASP3
47
Yersinia infection 36
12.29 TNF TLR4 MYD88 IL1B IL18 IL10
48
Bacterial infections in CF airways 23
Show member pathways
 12.27 TNF TLR4 MYD88 IL1B IFNGR1 IFNG
49
Alzheimers Disease 1
12.24 TNF IL1B FAS CASP3
50
Spinal Cord Injury 1
12.22 TNF TLR4 IL1B IFNG ICAM1 CXCL8
Sources

GO Terms for Lymphadenitis

About this section

Cellular components related to Lymphadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.22 TNF TLR4 SLC11A1 NOD2 MYD88 IL12RB1
2 extracellular space GO:0005615 9.97 TNF IL1B IL18 IL10 IFNG ICAM1
3 extracellular region GO:0005576 9.96 TNF IL1B IL18 IL10 IFNG FASLG
4 cell surface GO:0009986 9.61 TNF TLR4 NOD2 ICAM1 FASLG FAS
5 membrane raft GO:0045121 9.55 TNF ICAM1 FASLG FAS CASP3
6 death-inducing signaling complex GO:0031264 9.37 FAS CASP3
7 external side of plasma membrane GO:0009897 9.32 TNF TLR4 IL12RB1 ICAM1 FASLG FAS

Biological processes related to Lymphadenitis according to GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.34 TLR4 MYD88 IL1B IL18 IL12RB1 IL10
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.29 TNF TLR4 SLC11A1 NOD2 IL18 IL10
3 apoptotic process GO:0006915 10.24 MYD88 IL1B IFNG FASLG FAS CXCR3
4 defense response to bacterium GO:0042742 10.12 TNF TLR4 SLC11A1 NOD2 MYD88 IL10
5 positive regulation of gene expression GO:0010628 10.11 TNF TLR4 SLC11A1 MYD88 IL1B IL18
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.09 TNF TLR4 NOD2 ICAM1 CCR7
7 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.08 TNF TLR4 NOD2 MYD88 FASLG CCR7
8 cell-cell signaling GO:0007267 10.06 IL1B IL18 FASLG CXCL9
9 positive regulation of protein phosphorylation GO:0001934 10.05 TNF IL1B IFNG FAS
10 chemotaxis GO:0006935 10.03 CXCR3 CXCL9 CXCL8 CCR7
11 defense response GO:0006952 10.02 TNF NOD2 CXCL9 CXCL8
12 activation of MAPK activity GO:0000187 10.02 TNF TLR4 NOD2 IL1B
13 positive regulation of inflammatory response GO:0050729 10.02 TNF TLR4 IL1B IL18 IFNG
14 inflammatory response GO:0006954 10.02 TNF TLR4 SLC11A1 MYD88 IL1B IL18
15 response to virus GO:0009615 10.01 TNF MYD88 IFNGR1 IFNG
16 positive regulation of tumor necrosis factor production GO:0032760 10.01 TLR4 NOD2 MYD88 IFNGR1 IFNG
17 cellular response to interferon-gamma GO:0071346 10 TLR4 IL12RB1 ICAM1 FASLG
18 regulation of inflammatory response GO:0050727 10 TNF TLR4 NOD2 MYD88
19 cellular response to mechanical stimulus GO:0071260 9.99 TLR4 MYD88 IL1B FAS
20 apoptotic signaling pathway GO:0097190 9.99 TNF TLR4 FASLG FAS CASP3
21 chemokine-mediated signaling pathway GO:0070098 9.98 CXCR3 CXCL9 CXCL8 CCR7
22 cellular response to organic cyclic compound GO:0071407 9.98 TNF NOD2 IL1B IL18 CASP3
23 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.97 TNF TLR4 NOD2 IL1B IL18
24 positive regulation of interleukin-6 production GO:0032755 9.97 TNF TLR4 NOD2 MYD88 IL1B IFNG
25 positive regulation of interleukin-1 beta production GO:0032731 9.96 TNF TLR4 NOD2 IFNG
26 positive regulation of cytokine production GO:0001819 9.96 TNF SLC11A1 IL10 IFNG
27 extrinsic apoptotic signaling pathway GO:0097191 9.95 TNF IFNG FASLG FAS
28 positive regulation of interleukin-8 production GO:0032757 9.95 TNF TLR4 NOD2 MYD88 IL1B
29 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.95 TNF TLR4 NOD2 MYD88 IL1B IL18
30 phagocytosis GO:0006909 9.94 TLR4 SLC11A1 MYD88
31 negative regulation of tumor necrosis factor production GO:0032720 9.94 TLR4 NOD2 IL10
32 regulation of insulin secretion GO:0050796 9.94 TNF IL1B IFNG
33 negative regulation of interleukin-6 production GO:0032715 9.93 TNF TLR4 IL10
34 interferon-gamma-mediated signaling pathway GO:0060333 9.93 IFNGR1 IFNG ICAM1
35 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.93 TNF IL18 IFNG
36 response to glucocorticoid GO:0051384 9.93 TNF IL10 CASP3
37 positive regulation of interleukin-12 production GO:0032735 9.93 TLR4 NOD2 IFNG CCR7
38 positive regulation of chemokine production GO:0032722 9.93 TNF TLR4 MYD88 IFNG
39 positive regulation of phagocytosis GO:0050766 9.93 TNF SLC11A1 NOD2 IL1B IFNG
40 positive regulation of smooth muscle cell proliferation GO:0048661 9.92 TNF MYD88 IL18
41 positive regulation of neuron apoptotic process GO:0043525 9.92 TNF FASLG CASP3
42 regulation of cell adhesion GO:0030155 9.91 IL18 CXCR3 CXCL8
43 JNK cascade GO:0007254 9.91 TNF NOD2 MYD88
44 positive regulation of nitric oxide biosynthetic process GO:0045429 9.91 TNF TLR4 IL1B IFNG ICAM1
45 positive regulation of JNK cascade GO:0046330 9.91 TNF TLR4 NOD2 MYD88 IL1B CCR7
46 cellular response to lipopolysaccharide GO:0071222 9.91 TNF TLR4 NOD2 MYD88 IL1B IL10
47 interleukin-12-mediated signaling pathway GO:0035722 9.9 IL12RB1 IL10 IFNG
48 negative regulation of interferon-gamma production GO:0032689 9.9 TLR4 NOD2 IL10
49 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.9 TNF TLR4 NOD2 MYD88
50 cytokine-mediated signaling pathway GO:0019221 9.9 TNF MYD88 IL1B IL18 IL12RB1 IL10

Molecular functions related to Lymphadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.46 TLR4 ICAM1 FAS CXCR3
2 cytokine activity GO:0005125 9.23 TNF IL1B IL18 IL10 IFNG FASLG
3 death receptor binding GO:0005123 9.13 MYD88 FASLG CASP3
Sources

Sources for Lymphadenitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....