MCID: LYM021
MIFTS: 57

Lymphadenitis

Categories: Immune diseases, Skin diseases

Aliases & Classifications for Lymphadenitis

MalaCards integrated aliases for Lymphadenitis:

Name: Lymphadenitis 12 43 15 71
Acute Lymphadenitis 12 71 32
Chronic Lymphadenitis 12 71
Inflammation of Lymph Node 12
Chronic Adenitis 12
Acute Adenitis 12
Adenitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1602
ICD9CM 34 289.1 683
MeSH 43 D008199
ICD10 32 I88.1 L04 L04.9
UMLS 71 C0024205 C0154304 C0157705

Summaries for Lymphadenitis

MalaCards based summary : Lymphadenitis, also known as acute lymphadenitis, is related to axillary adenitis and kawasaki disease, and has symptoms including nausea and vomiting, abdominal pain and syncope. An important gene associated with Lymphadenitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Azithromycin and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, t cells and testes, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Increased viability with MLN4924 (a NAE inhibitor)

Related Diseases for Lymphadenitis

Diseases related to Lymphadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 941)
# Related Disease Score Top Affiliating Genes
1 axillary adenitis 33.2 IL12RB1 IFNGR1
2 kawasaki disease 33.1 TNF IL1B IL18 IL10
3 chronic granulomatous disease 32.9 TNF IL1B IFNG ICAM1 CXCL8
4 aphthous stomatitis 31.7 TNF TLR4 IL1B IL18 IL10 IFNG
5 tularemia 31.4 TNF TLR4 IL1B IL18
6 extrapulmonary tuberculosis 31.3 TNF IL1B IL10 IFNGR1 IFNG CXCL9
7 appendicitis 31.3 TNF TLR4 IL1B IL10 IFNG CXCL8
8 exanthem 31.3 TNF IL1B IL10 IFNG CXCL8
9 thyroiditis 31.2 TNF IL10 FASLG
10 neutropenia 31.2 TNF TLR4 IL1B IL10 IFNG FASLG
11 cellulitis 31.1 TNF IL1B IL10 IFNG
12 obstructive jaundice 31.1 TNF TLR4 CXCL8
13 mycobacterium fortuitum 31.1 IL12RB1 IFNGR1 CXCL8
14 toxoplasmosis 31.1 TNF TLR4 STAT3 IL1B IL10 IFNGR1
15 cryptococcosis 31.1 TNF IL10 IFNG
16 aseptic meningitis 31.0 TNF IL1B IL10 IFNG CXCL8
17 familial mediterranean fever 31.0 TNF TLR4 NOD2 IL1B IL18 IL10
18 syphilis 31.0 TNF IFNG FAS CD209
19 multidrug-resistant tuberculosis 31.0 TNF IL10 IFNG
20 lymphoma 31.0 STAT3 IL2RA IL10 FAS CCR7 CASP3
21 abdominal tuberculosis 31.0 TNF IL12RB1 IFNG
22 pharyngitis 31.0 TNF IL1B CXCL8
23 pyoderma 31.0 TNF NOD2 IL1B CXCL8
24 histoplasmosis 30.9 TNF IL12RB1 IFNG
25 encephalitis 30.9 TNF IL1B IL10 CXCL9 CD209
26 plague 30.9 TNF TLR4 IL1B IL10
27 chickenpox 30.9 TNF IL10 IFNG
28 human immunodeficiency virus type 1 30.9 TNF IL10 IFNG CD209 CCR7
29 pulmonary tuberculosis 30.9 TNF TLR4 IL2RA IL1B IL18 IL12RB1
30 acquired immunodeficiency syndrome 30.8 TNF IL2RA IL1B IL10 IFNG ICAM1
31 miliary tuberculosis 30.8 TNF IL12RB1 IFNGR1 IFNG
32 ileitis 30.8 TNF TLR4 STAT3 NOD2 IL10
33 purpura 30.8 TNF IL10 IFNG
34 pericarditis 30.8 TNF IL1B IFNG CXCL8
35 intestinal tuberculosis 30.8 TNF NOD2 IFNG
36 allergic hypersensitivity disease 30.8 TNF IL10 IFNG ICAM1 CXCL8
37 rheumatic heart disease 30.7 TNF IL1B IL10
38 meningitis 30.7 TNF TLR4 IL1B IL18 IL10 IFNG
39 chlamydia 30.7 TNF TLR4 IL1B IL18 IL10 IFNG
40 listeriosis 30.7 TNF TLR4 IL1B IL10
41 adult-onset still's disease 30.7 TNF IL1B IL18 CXCL8
42 cyclic neutropenia 30.7 TNF IL1B IFNG CXCL8
43 typhoid fever 30.7 TNF TLR4 IL1B IFNGR1 IFNG
44 mixed connective tissue disease 30.7 TNF IL10 IFNG
45 filariasis 30.7 TNF TLR4 IL10 IFNG
46 herpes zoster 30.7 TNF IL10 IFNG
47 panniculitis 30.7 IFNG FASLG FAS CASP3
48 peritonitis 30.6 TNF TLR4 IL1B IL18 IL10 IFNG
49 connective tissue disease 30.6 TNF IL1B IL10 IFNG CXCL8
50 pleurisy 30.6 TNF TLR4 IFNG ICAM1 CXCL8

Comorbidity relations with Lymphadenitis via Phenotypic Disease Network (PDN):


Prostate Cancer

Graphical network of the top 20 diseases related to Lymphadenitis:



Diseases related to Lymphadenitis

Symptoms & Phenotypes for Lymphadenitis

UMLS symptoms related to Lymphadenitis:


nausea and vomiting, abdominal pain, syncope, signs and symptoms of ill-defined conditions, (non-specific) malaise and fatigue, adenitis, fever of unknown origin

GenomeRNAi Phenotypes related to Lymphadenitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 ICAM1 NOD2
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 CASP3 FAS FASLG IL10 IL18 IL1B
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.6 CASP3 CXCL8 FAS IL10 IL18 IL1B
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.6 CASP3 CXCL8 FAS ICAM1 IL10 IL18
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.6 ICAM1
6 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.46 CASP3 CXCL8 IL2RA TNF

MGI Mouse Phenotypes related to Lymphadenitis:

45 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.45 CASP3 CCR7 CXCR3 FAS FASLG ICAM1
2 homeostasis/metabolism MP:0005376 10.44 CASP3 CCR7 CXCR3 FAS FASLG ICAM1
3 cardiovascular system MP:0005385 10.43 CASP3 CXCR3 FAS FASLG ICAM1 IFNG
4 cellular MP:0005384 10.42 CASP3 CCR7 CXCR3 FAS FASLG ICAM1
5 immune system MP:0005387 10.42 CASP3 CCR7 CXCR3 FAS FASLG ICAM1
6 digestive/alimentary MP:0005381 10.4 CASP3 CCR7 FAS FASLG ICAM1 IFNG
7 growth/size/body region MP:0005378 10.35 CASP3 FAS ICAM1 IFNG IL10 IL12RB1
8 mortality/aging MP:0010768 10.31 CASP3 CXCR3 FAS FASLG ICAM1 IFNG
9 endocrine/exocrine gland MP:0005379 10.29 CASP3 CCR7 FAS FASLG ICAM1 IFNG
10 integument MP:0010771 10.29 CASP3 FAS FASLG ICAM1 IFNG IFNGR1
11 nervous system MP:0003631 10.13 CASP3 CCR7 FAS FASLG ICAM1 IFNG
12 craniofacial MP:0005382 10.11 CASP3 FAS IFNG IL10 IL1B STAT3
13 neoplasm MP:0002006 10.11 CXCR3 FAS FASLG ICAM1 IFNG IFNGR1
14 liver/biliary system MP:0005370 10.06 FAS FASLG IFNG IFNGR1 IL10 STAT3
15 muscle MP:0005369 10.06 CASP3 FAS ICAM1 IFNG IL10 IL18
16 renal/urinary system MP:0005367 9.86 CASP3 CXCR3 FAS FASLG IFNG IFNGR1
17 respiratory system MP:0005388 9.85 CASP3 CXCR3 FAS FASLG IFNG IL10
18 skeleton MP:0005390 9.73 CASP3 FAS FASLG IFNG IFNGR1 IL10
19 vision/eye MP:0005391 9.4 CASP3 CCR7 FAS FASLG ICAM1 IFNG

Drugs & Therapeutics for Lymphadenitis

Drugs for Lymphadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 447043 55185
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3
BCG vaccine Investigational Phase 4
4 Vaccines Phase 4
5
Clavulanate Approved, Vet_approved Phase 3 58001-44-8 5280980
6
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
7
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
8 Gentamicins Phase 3
9 Anti-Bacterial Agents Phase 3
10 Anti-Infective Agents Phase 3
11 Amoxicillin-Potassium Clavulanate Combination Phase 3
12 beta-Lactamase Inhibitors Phase 3
13 Hormones Phase 3
14 Hormone Antagonists Phase 3
15 glucocorticoids Phase 3
16 Antineoplastic Agents, Hormonal Phase 3
17 Anti-Inflammatory Agents Phase 3
18 Antiparasitic Agents Phase 3
19 Antiprotozoal Agents Phase 3
20 Antimalarials Phase 3
21
Zinc Approved, Investigational Phase 2 7440-66-6 32051
22
Zinc oxide Approved Phase 2 1314-13-2
23 Histone Deacetylase Inhibitors Phase 2
24 Givinostat hydrochloride Phase 2
25 Dermatologic Agents Phase 2
26 Sunscreening Agents Phase 2
27 Radiation-Protective Agents Phase 2
28 Calcium, Dietary Phase 2
29 Protective Agents Phase 2
30
Calcium Nutraceutical Phase 2 7440-70-2 271
31
Formaldehyde Approved, Vet_approved 50-00-0 712
32
Ethanol Approved 64-17-5 702
33
Iodine Approved, Investigational 7553-56-2 807
34 Disinfectants
35 Fluorides
36 Fluorodeoxyglucose F18
37 Adjuvants, Immunologic
38 Immunologic Factors
39 cadexomer iodine

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Open Label Study of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
2 Evaluating the Non-specific Effects of Different BCG Strains in Guinea-Bissau: Randomized Trial of the Impact on Early-life Hospital Admissions and Deaths Active, not recruiting NCT03400878 Phase 4
3 Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis: A Randomized Controlled Study Recruiting NCT03132116 Phase 3 gentamicin;placebo
4 Evaluation of the Efficacy of an Antibiotic Combined With Standard Treatment in Severe Alcoholic Hepatitis Active, not recruiting NCT02281929 Phase 3 Amoxicillin;Placebo;Prednisolone
5 A Multi-center, Double-blind, Randomized, 24-month Study, to Compare the Efficacy of Doxycycline Once Daily for 6 Weeks Versus Placebo in Improving Filarial Lymphedema Independent of Active Filarial Infection Active, not recruiting NCT02929134 Phase 3 Doxycycline;Placebo
6 A Multi-center, Double-blind, Randomized, 24-month Study, to Compare the Efficacy of Doxycycline Once Daily for 6 Weeks Versus Placebo in Improving Filarial Lymphedema Independent of Active Filarial Infection Active, not recruiting NCT02929121 Phase 3 Doxycycline;Placebo
7 A Multi-center, Double-blind, Randomized, 24-month Study, to Compare the Efficacy of Doxycycline Once Daily for 6 Weeks Versus Placebo in Improving Filarial Lymphedema Independent of Active Filarial Infection Active, not recruiting NCT02927496 Phase 3 Doxycycline;Placebo
8 A Multi-national, Multi-center, Randomized, Double-Blind, Active-Controlled, Phase III Study to Investigate the Efficacy and Safety of 'GC3107(BCG Vaccine)' After Intradermal Administration in Healthy Infants Not yet recruiting NCT03947138 Phase 3
9 Comparison of Antibiotic Therapy Alone or Combined With Corticosteroids for the Treatment of Nontuberculous Mycobacterial Cervicofacial Lymphadenitis in Children: A Randomized Double-Blind Placebo-Controlled Study Withdrawn NCT01614977 Phase 3 Methylprednisoline
10 The Effects and Side Effects of ITS2357 in Autoinflammatory Syndromes Unknown status NCT00442182 Phase 2 ITF2357
11 Clinical, Microbiological and Quality of Life Outcomes Following Use of Systemic and Local Antimicrobials in the Management of Odontogenic Infections in Paediatric Patients Completed NCT03761264 Phase 2 Odontopaste®;Pulpdent;Amoxicillin
12 Effects of Probiotic Addition to Corticosteroid Treatment for PFAPA Withdrawn NCT02535962 Phase 2
13 Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Recruiting NCT02775994 Phase 1 Canakinumab
14 CT Enlarged Mediastinal/Hilar Lymph Nodes Not Visible on Chest X-ray in the Non Cancer Patient : Diagnosis and Clinical Implications Using Endobronchial or Esophageal Ultrasound Controlled Needle Aspiration E(B)US-NA Unknown status NCT01383226
15 Ultrasonographic Differentiation Between Kikuchi's Disease and Lymphoma in Patients With Cervical Lymphadenopathy Unknown status NCT01310933
16 Role of Doppler Ultrasound in Evaluation of Superficial Soft Tissue Masses Unknown status NCT03171857
17 Comparison of the Diagnostic Accuracy of Nested and Real-time Polymerase Chain Reaction for Mycobacterium Tuberculosis Using EBUS-TBNA Samples in Patients With Isolated Intrathoracic Lymphadenopathy Unknown status NCT02497079
18 Dx Mediastinal Malignant LAP:Compare PET and EBUS-TBNA Unknown status NCT01367366
19 Diagnosis of Mediastinal Tuberculous Lymphadenopathy by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA) Unknown status NCT01121432
20 Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) Completed NCT01406275 Amoxicillin and clavulanate
21 Evaluation of Efficacy of Thrice Weekly DOTS Regimen in Tubercular Pleural Effusion at 6 Months Completed NCT01560078
22 Rapid Strep Testing in Children With Recent Streptococcal Pharyngitis Completed NCT03055728
23 Rapid Characterization of Mycobacteria and Drug Resistance In Paucibacillary TB Completed NCT00421798
24 Tuberculosis Immunity in Children Completed NCT00170638
25 Value of EBUS-TBNA for Mediastinal Lymph Nodes in Non-small Cell Lung Cancer in a Tuberculosis-endemic Country Completed NCT01156623
26 Explanations for Negative Laparoscopic Appendectomies and Normal Laparoscopies. What Does the Patient Suffer From When the Appendix Proves to be Healthy? Completed NCT03349814
27 Tonsillotomy or Follow-up in PFAPA -Syndrome - Randomised, Controlled Study Using Sequential Design Recruiting NCT03331497
28 Evaluation of a Novel Axillary Lymph Node Ink Localization Technique: A Feasibility Study Recruiting NCT04136496
29 The Role of Maternal TB Infection for Adverse Pregnancy and Infant Health Outcomes in Ethiopia - a Long-term Prospective Cohort Study Active, not recruiting NCT03305991
30 BCG Vaccination Scar Formation in Children Under Five Years :Factors Affecting Its Formation and Subsequent Adverse Effects . Not yet recruiting NCT03548233
31 Treatment Efficacy and Safety of Low-dose Radioiodine Ablation for Intermediate-risk Differentiated Thyroid Carcinoma Patients Without Metastasis: a Double-blind Randomized Clinical Trial Not yet recruiting NCT04354324 Radioiodine
32 Clinical Studies of Kikuchi's Disease Withdrawn NCT00172445

Search NIH Clinical Center for Lymphadenitis

Cochrane evidence based reviews: lymphadenitis

Genetic Tests for Lymphadenitis

Anatomical Context for Lymphadenitis

MalaCards organs/tissues related to Lymphadenitis:

40
Lymph Node, T Cells, Testes, Skin, Thyroid, B Cells, Breast

Publications for Lymphadenitis

Articles related to Lymphadenitis:

(show top 50) (show all 6140)
# Title Authors PMID Year
1
Tuberculosis-associated chylothorax revealing an enlarged lymphatic duct due to tuberculosis lymphadenitis. 61
32566230 2020
2
Low body mass index has minimal impact on plasma levels of cytokines and chemokines in tuberculous lymphadenitis. 61
32420460 2020
3
Mediastinal Lymphadenitis Due to Nocardia Infection. 61
32569081 2020
4
Molecular targeting of PD-1 signaling pathway as a novel therapeutic approach in HTLV-1 infection. 61
32283259 2020
5
Imaging and clinical features of breast tuberculosis: a review series of 62 cases. 61
32321647 2020
6
Unilateral inguinal lymphadenitis caused by Yersinia pseudotuberculosis. A case report. 61
32386928 2020
7
False-positive Results of Quantiferon-Tb-Gold Assay in Children. 61
32084111 2020
8
Far Eastern Scarlet-Like Fever is a Special Clinical and Epidemic Manifestation of Yersinia pseudotuberculosis Infection in Russia. 61
32498317 2020
9
Long-term outcome of surgical excision for treatment of cervicofacial granulomatous lymphadenitis in children. 61
32144570 2020
10
Disseminated Cryptococcosis After Liver Transplant: A Case Report. 61
30696395 2020
11
What is the optimal management of pediatric nontuberculous mycobacterial cervicofacial lymphadenitis? 61
31825090 2020
12
Clinical IRAK4 deficiency caused by homozygosity for the novel IRAK4 (c.1049delG, p.Gly350Glufs*15) variant. 61
32532880 2020
13
HHV8-positive, EBV-positive Hodgkin lymphoma-like large B cell lymphoma: expanding the spectrum of HHV8 and EBV-associated lymphoproliferative disorders. 61
32529584 2020
14
Parotitis-Like Symptoms Associated with COVID-19, France, March-April 2020. 61
32491984 2020
15
Caprine nodular thelitis due to Mycobacterium uberis: A series of 26 cases in 11 dairy goat farms in Western France. 61
32540717 2020
16
MELIOIDOSIS IN A BOTTLENOSE DOLPHIN (TURSIOPS TRUNCATUS) AFTER A HURRICANE IN THE CARIBBEAN ISLANDS. 61
32549577 2020
17
The combination of Brazilian red propolis and recombinant protein rCP01850 in the immunoprophylaxis of Corynebacterium pseudotuberculosis infection in mice. 61
32569789 2020
18
Clinical manifestations and genetic analysis of 4 children with chronic granulomatous disease. 61
32502033 2020
19
Phylogenomic characterisation of a novel corynebacterial species pathogenic to animals. 61
32500295 2020
20
Utility assessment of an Enzyme-linked immunosorbent assay for detection of subclinical cases of caseous lymphadenitis in small ruminant flocks. 61
32567811 2020
21
Sterile granulomatous dermatitis and lymphadenitis (juvenile cellulitis) in adult dogs: a retrospective analysis of 90 cases (2004-2018). 61
31789433 2020
22
Relapse of cervical tuberculous lymphadenitis immediately after completion of effective anti-tuberculosis treatments. 61
32269777 2020
23
Cervicofacial non-tuberculous mycobacterial lymphadenitis: clinical determinants of incomplete surgical removal. 61
32371179 2020
24
Suppurative cervical lymphadenitis in adult: An analysis of predictors for surgical drainage. 61
32370913 2020
25
Diminished systemic levels of antimicrobial peptides in tuberculous lymphadenitis and their reversal after anti-tuberculosis treatment. 61
32275232 2020
26
Meningomyeloencephalitis secondary to Mycobacterium haemophilum infection in AIDS. 61
32430060 2020
27
Prediction Model for the Differential Diagnosis of Kawasaki Disease and Acute Cervical Lymphadenitis in Patients Initially Presenting with Fever and Cervical Lymphadenitis. 61
32450069 2020
28
Histology-Independent Signature Distinguishes Kikuchi-Fujimoto Disease/Systemic Lupus Erythematosus-Associated Lymphadenitis From Benign and Malignant Lymphadenopathies. 61
32367142 2020
29
A melting, encapsulated, calcified pulmonary nodule in a healthy 51-year-old woman: a case report. 61
32357852 2020
30
From Diagnosis to Treatment of Pediatric Tuberculosis: Ten Years Experience in a Single Institution. 61
32088989 2020
31
Retrospective assessment of the clinical relevance of surgical biopsies of abdominal lymph nodes in cats: 51 cases (2014-2018). 61
32419573 2020
32
[One case of histiocytic necrotizing lymphadenitis with severe thrombocytopenia]. 61
32209200 2020
33
Lymphadenitis and aortitis due to Brucella melitensis infection. 61
31950431 2020
34
Imaging Strategies and Outcomes in Children Hospitalized with Cervical Lymphadenitis. 61
31891560 2020
35
Submandibular lymphadenitis due to Mycobacterium malmoense: first reported case from Greece. 61
32341090 2020
36
Surgical management of atypical mycobacterial cervical lymphadenitis in an outbreak of odontological infection. 61
31981916 2020
37
[Cervical lymphadenitis caused by non-tuberculous mycobacteria in children with different residence]. 61
32268397 2020
38
Retroperitoneal fibromatosis presenting as a mesenteric mass: A case report. 61
32332594 2020
39
High prevalence of subclinical paratuberculosis in buffaloes (Bubalus bubalis) in Maranhão, Brazil. 61
32291741 2020
40
Bacillus Calmette-Guérin Cervical Lymphadenitis in a 6-Year-Old Boy on Infliximab for Inflammatory Bowel Disease. 61
32345827 2020
41
Exploring the presence of dental anomalies as a consequence of treatment of malignancy: A case report. 61
32322476 2020
42
An evidence-based clinical pathway for the diagnosis of tuberculous lymphadenitis: A systematic review. 61
32474531 2020
43
[Efficacy of medicinal penetration on acupoint as adjunctive therapy on histiocytic necrotizing lymphadenitis of heat-toxin syndrome: a randomized controlled trial]. 61
32275363 2020
44
Kikuchi-Fujimoto Disease and Prognostic Implications. 61
30888636 2020
45
Triple infection with Cryptococcus, varicella-zoster virus, and Mycobacterium abscessus in a patient with anti-interferon-gamma autoantibodies: a case report. 61
32188404 2020
46
Risk Factors for Complicated Lymphadenitis Caused by Nontuberculous Mycobacteria in Children. 61
32091372 2020
47
In Response to the Management of Nontuberculous Mycobacterial Cervicofacial Lymphadenitis: A View Beyond Surgery. 61
32154910 2020
48
In Reference to The Management of Nontuberculous Mycobacterial Cervicofacial Lymphadenitis: A View Beyond Surgery. 61
32154935 2020
49
A Pseudomonas monteilii unilateral inguinofemoral granulomatous lymphadenitis in a two-year-old girl. A case report. 61
32153254 2020
50
Strong association of Torque teno virus/Torque teno-like minivirus to Kikuchi-Fujimoto lymphadenitis (histiocytic necrotizing lymphadenitis) on quantitative analysis. 61
31782015 2020

Variations for Lymphadenitis

Expression for Lymphadenitis

Search GEO for disease gene expression data for Lymphadenitis.

Pathways for Lymphadenitis

Pathways related to Lymphadenitis according to GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.18 TNF TLR4 STAT3 NOD2 IL2RA IL1B
2
Show member pathways
13.97 TNF STAT3 IL2RA IL1B IL18 IL12RB1
3
Show member pathways
13.71 TNF STAT3 IL2RA IL1B IL18 IL12RB1
4
Show member pathways
13.67 TNF TLR4 STAT3 IL2RA IL1B IL18
5
Show member pathways
13.45 TNF STAT3 NOD2 IL2RA IL1B IL18
6
Show member pathways
13.45 TNF TLR4 STAT3 IL2RA IL1B IL18
7
Show member pathways
13.43 TNF IL2RA IL1B IL18 IL12RB1 IL10
8
Show member pathways
13.31 TNF TLR4 STAT3 IL2RA IL1B IFNGR1
9
Show member pathways
13.2 TNF TLR4 STAT3 IL1B IL10 IFNGR1
10
Show member pathways
13.13 TNF TLR4 STAT3 IL1B IFNGR1 ICAM1
11
Show member pathways
13.08 TNF TLR4 IL2RA FASLG FAS CASP3
12
Show member pathways
13.05 STAT3 FASLG FAS CXCR3 CXCL9 CXCL8
13 13.04 STAT3 IL2RA IL12RB1 IFNGR1 IFNG FASLG
14
Show member pathways
13.01 TNF IL2RA IL1B IL10 IFNG ICAM1
15 12.97 TNF IL1B IFNGR1 IFNG FASLG FAS
16
Show member pathways
12.88 TNF STAT3 IL1B IFNGR1 IFNG FASLG
17
Show member pathways
12.86 TNF TLR4 NOD2 IL1B IL18 CXCL8
18 12.85 TNF IL1B FASLG FAS CASP3
19
Show member pathways
12.83 TNF IL2RA IL18 IL12RB1 IL10 IFNGR1
20
Show member pathways
12.82 TNF TLR4 STAT3 IL1B IL10 IFNGR1
21
Show member pathways
12.8 TNF STAT3 IL1B IL18 IL12RB1 IL10
22
Show member pathways
12.77 TNF STAT3 FASLG FAS CASP3
23
Show member pathways
12.76 TNF TLR4 IL1B FASLG FAS CASP3
24 12.76 TNF STAT3 IL2RA IL1B IL10 IFNG
25
Show member pathways
12.72 TNF IFNGR1 IFNG ICAM1 FASLG FAS
26
Show member pathways
12.65 TNF TLR4 STAT3 NOD2 IL2RA IL1B
27
Show member pathways
12.63 STAT3 IL2RA IL12RB1 IL10 IFNGR1 IFNG
28
Show member pathways
12.55 TNF IL2RA IL18 IL10 CXCR3 CXCL9
29 12.54 TNF TLR4 IL1B IL18 CXCL8
30
Show member pathways
12.54 TNF STAT3 IL1B IFNG CXCL8 CASP3
31
Show member pathways
12.51 TNF TLR4 IL1B IFNGR1 IFNG CXCL8
32 12.51 TNF TLR4 IL1B IL18 CXCL8 CASP3
33 12.51 TNF TLR4 STAT3 FASLG FAS CASP3
34 12.48 TNF TLR4 IL1B IL18 FASLG FAS
35
Show member pathways
12.47 TNF TLR4 STAT3 IL1B IL10 IFNGR1
36
Show member pathways
12.46 TNF IL2RA IL1B IL18 IL10 IFNG
37 12.44 TNF TLR4 NOD2 IL1B IL18 CXCL8
38
Show member pathways
12.41 TNF IL1B IFNG ICAM1
39
Show member pathways
12.41 TNF TLR4 STAT3 IL1B IFNGR1 IFNG
40
Show member pathways
12.39 TLR4 FASLG FAS CASP3
41 12.39 TNF TLR4 STAT3 IFNGR1 IFNG CASP3
42
Show member pathways
12.39 TNF TLR4 IL1B IFNGR1 IFNG FASLG
43 12.35 TNF IL1B IL10 CXCL8 CASP3
44 12.34 TNF FASLG FAS CASP3
45
Show member pathways
12.32 TNF FASLG FAS CASP3
46
Show member pathways
12.31 TNF IL1B IL10 CD209
47 12.25 TNF TLR4 IL1B IL18 IL10 CXCL8
48 12.25 TNF TLR4 IL1B IFNG ICAM1 CXCL8
49 12.24 TNF IL1B FAS CASP3
50 12.23 TNF IL2RA IL10 IFNG CD209 CCR7

GO Terms for Lymphadenitis

Cellular components related to Lymphadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.22 TNF TLR4 STAT3 NOD2 IL2RA IL12RB1
2 extracellular region GO:0005576 10.02 TNF IL1B IL18 IL10 IFNG FASLG
3 extracellular space GO:0005615 9.91 TNF IL1B IL18 IL10 IFNG ICAM1
4 cell surface GO:0009986 9.65 TNF TLR4 NOD2 IL2RA ICAM1 FASLG
5 membrane raft GO:0045121 9.55 TNF ICAM1 FASLG FAS CASP3
6 death-inducing signaling complex GO:0031264 9.37 FAS CASP3
7 external side of plasma membrane GO:0009897 9.36 TNF TLR4 IL2RA IL12RB1 ICAM1 FASLG

Biological processes related to Lymphadenitis according to GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.29 TNF TLR4 STAT3 NOD2 IL1B IL18
2 signal transduction GO:0007165 10.27 TLR4 STAT3 IL1B IL18 IL12RB1 IL10
3 apoptotic process GO:0006915 10.22 IL2RA IL1B IFNG FASLG FAS CXCR3
4 positive regulation of gene expression GO:0010628 10.17 TNF TLR4 STAT3 IL1B IL18 IFNGR1
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.08 TNF TLR4 NOD2 ICAM1 CCR7
6 cell-cell signaling GO:0007267 10.06 IL1B IL18 FASLG CXCL9
7 positive regulation of protein phosphorylation GO:0001934 10.04 TNF IL1B IFNG FAS
8 defense response GO:0006952 10.04 TNF STAT3 NOD2 CXCL9 CXCL8
9 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.04 TNF TLR4 NOD2 IL1B FASLG CCR7
10 chemotaxis GO:0006935 10.03 CXCR3 CXCL9 CXCL8 CCR7
11 activation of MAPK activity GO:0000187 10.01 TNF TLR4 NOD2 IL1B
12 cellular response to interferon-gamma GO:0071346 9.99 TLR4 IL12RB1 ICAM1 FASLG
13 positive regulation of inflammatory response GO:0050729 9.99 TNF TLR4 IL1B IL18 IFNG
14 response to organic substance GO:0010033 9.98 TNF STAT3 IL10 CASP3
15 chemokine-mediated signaling pathway GO:0070098 9.97 CXCR3 CXCL9 CXCL8 CCR7
16 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.97 TNF STAT3 IL18 IFNG
17 positive regulation of JNK cascade GO:0046330 9.97 TNF TLR4 NOD2 IL1B CCR7
18 apoptotic signaling pathway GO:0097190 9.95 TNF TLR4 FASLG FAS CASP3
19 response to lipopolysaccharide GO:0032496 9.95 TLR4 IL1B IL10 ICAM1 FASLG CCR7
20 cellular response to mechanical stimulus GO:0071260 9.94 TLR4 IL1B FAS
21 positive regulation of interleukin-6 production GO:0032755 9.94 TNF TLR4 NOD2 IL1B
22 neutrophil chemotaxis GO:0030593 9.93 IL1B CXCL9 CXCL8
23 interferon-gamma-mediated signaling pathway GO:0060333 9.93 IFNGR1 IFNG ICAM1
24 regulation of insulin secretion GO:0050796 9.93 TNF IL1B IFNG
25 response to glucocorticoid GO:0051384 9.92 TNF IL10 CASP3
26 positive regulation of T cell proliferation GO:0042102 9.92 IL2RA IL1B CD209
27 extrinsic apoptotic signaling pathway GO:0097191 9.92 TNF IFNG FASLG FAS
28 positive regulation of neuron apoptotic process GO:0043525 9.91 TNF FASLG CASP3
29 regulation of cell adhesion GO:0030155 9.91 IL18 CXCR3 CXCL8
30 positive regulation of interleukin-6 secretion GO:2000778 9.91 TNF TLR4 IL1B IFNG
31 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.91 TNF TLR4 NOD2 IL1B IL18
32 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 TNF TLR4 STAT3 NOD2 IL1B IL18
33 positive regulation of phagocytosis GO:0050766 9.9 TNF IL1B IFNG
34 interleukin-12-mediated signaling pathway GO:0035722 9.9 IL12RB1 IL10 IFNG
35 lipopolysaccharide-mediated signaling pathway GO:0031663 9.9 TNF TLR4 IL1B IL18
36 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.89 TNF STAT3 IL10
37 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.89 ICAM1 FASLG FAS
38 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.89 IL1B FAS CASP3
39 cellular response to organic substance GO:0071310 9.89 IL1B ICAM1 CASP3
40 negative regulation of interleukin-6 production GO:0032715 9.89 TNF TLR4 IL10
41 positive regulation of cytokine secretion GO:0050715 9.88 TNF IL10 IFNG
42 microglial cell activation GO:0001774 9.88 TNF IFNGR1 IFNG
43 positive regulation of interleukin-8 production GO:0032757 9.88 TNF TLR4 NOD2 IL1B
44 positive regulation of interferon-gamma production GO:0032729 9.88 TNF TLR4 IL1B IL18 IL12RB1
45 positive regulation of activated T cell proliferation GO:0042104 9.87 IL2RA IL18 IL12RB1
46 positive regulation of interleukin-12 production GO:0032735 9.87 TLR4 IFNG CCR7
47 leukocyte chemotaxis GO:0030595 9.86 IL10 CXCL9 CXCL8
48 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.86 TNF TLR4 STAT3 NOD2
49 cellular response to lipopolysaccharide GO:0071222 9.86 TNF TLR4 NOD2 IL1B IL10 ICAM1
50 inflammatory response GO:0006954 9.85 TNF TLR4 STAT3 IL2RA IL1B IL18

Molecular functions related to Lymphadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 TNF TLR4 STAT3 NOD2 IL2RA IL1B
2 cytokine activity GO:0005125 9.23 TNF IL1B IL18 IL10 IFNG FASLG

Sources for Lymphadenitis

3 CDC
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10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
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30 HMDB
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68 SNOMED-CT via HPO
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70 Tocris
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72 UMLS via Orphanet
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