MCID: LYM035
MIFTS: 29

Lymphangiectasis

Categories: Gastrointestinal diseases, Immune diseases, Rare diseases

Aliases & Classifications for Lymphangiectasis

MalaCards integrated aliases for Lymphangiectasis:

Name: Lymphangiectasis 53 73
Lymphangiectasia 53

Classifications:



External Ids:

UMLS 73 C0024214

Summaries for Lymphangiectasis

MalaCards based summary : Lymphangiectasis, also known as lymphangiectasia, is related to lymphangioma and hennekam lymphangiectasia-lymphedema syndrome 2. An important gene associated with Lymphangiectasis is ACTC1 (Actin, Alpha, Cardiac Muscle 1), and among its related pathways/superpathways are Cytoskeletal Signaling and Striated Muscle Contraction. The drugs Sirolimus and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include small intestine, lung and heart.

Wikipedia : 76 Lymphangiectasia is a pathologic dilation of lymph vessels. When it occurs in the intestines of dogs,... more...

Related Diseases for Lymphangiectasis

Diseases related to Lymphangiectasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 203)
# Related Disease Score Top Affiliating Genes
1 lymphangioma 30.0 ACTC1 VIM
2 hennekam lymphangiectasia-lymphedema syndrome 2 12.5
3 hennekam lymphangiectasia-lymphedema syndrome 3 12.4
4 aplasia cutis congenita with intestinal lymphangiectasia 12.4
5 secondary intestinal lymphangiectasia 12.1
6 mullerian derivatives, persistence of, with lymphangiectasia and postaxial polydactyly 11.3
7 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 11.2
8 lymphedema, hereditary, iii 11.2
9 lymphangiectasia, pulmonary, congenital 11.2
10 lymphangiectasia, intestinal 11.0
11 hennekam lymphangiectasia-lymphedema syndrome 1 11.0
12 hennekam syndrome 11.0
13 primary intestinal lymphangiectasia 11.0
14 lymphedema 10.3
15 lymphoma 10.2
16 hydrops fetalis, nonimmune, and/or atrial septal defect 10.1
17 fetal edema 10.1
18 hydrops fetalis 10.1
19 breast cancer 10.1
20 protein-losing enteropathy 10.1
21 ascites, chylous 10.1
22 yellow nail syndrome 10.0
23 nephrotic syndrome 10.0
24 noonan syndrome 1 10.0
25 osteomalacia 10.0
26 constrictive pericarditis 10.0
27 pericarditis 10.0
28 pseudo-turner syndrome 10.0
29 b-cell lymphomas 10.0
30 filariasis 10.0
31 tuberous sclerosis 10.0
32 aplasia cutis congenita 10.0
33 immune hydrops fetalis 10.0
34 glomangiomyoma 10.0 ACTC1 VIM
35 angiolipoma 10.0 ACTC1 VIM
36 intravascular papillary endothelial hyperplasia 10.0 ACTC1 VIM
37 cutaneous leiomyosarcoma 10.0 ACTC1 VIM
38 leiomyosarcoma 10.0 ACTC1 VIM
39 spindle cell lipoma 10.0 ACTC1 VIM
40 parachordoma 10.0 ACTC1 VIM
41 ossifying fibromyxoid tumor 10.0 ACTC1 VIM
42 epithelioid leiomyosarcoma 9.9 ACTC1 VIM
43 benign metastasizing leiomyoma 9.9 ACTC1 VIM
44 leiomyoma 9.9 ACTC1 VIM
45 adenofibroma 9.9 ACTC1 VIM
46 spiradenoma 9.9 ACTC1 VIM
47 angiocentric glioma 9.9 ACTC1 VIM
48 perivascular epithelioid cell tumor 9.9 ACTC1 VIM
49 cutaneous fibrous histiocytoma 9.9 ACTC1 VIM
50 fibrous histiocytoma 9.9 ACTC1 VIM

Graphical network of the top 20 diseases related to Lymphangiectasis:



Diseases related to Lymphangiectasis

Symptoms & Phenotypes for Lymphangiectasis

Drugs & Therapeutics for Lymphangiectasis

Drugs for Lymphangiectasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
2
Everolimus Approved Phase 2 159351-69-6 6442177
3
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
4 Antibiotics, Antitubercular Phase 2
5 Immunologic Factors Phase 2
6 Immunosuppressive Agents Phase 2
7 Anti-Infective Agents Phase 2
8 Anti-Bacterial Agents Phase 2
9 Antifungal Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies Active, not recruiting NCT00975819 Phase 2 sirolimus
2 Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders Recruiting NCT02156115
3 International Lymphatic Disease and Lymphedema Registry Recruiting NCT01336790

Search NIH Clinical Center for Lymphangiectasis

Genetic Tests for Lymphangiectasis

Anatomical Context for Lymphangiectasis

MalaCards organs/tissues related to Lymphangiectasis:

41
Small Intestine, Lung, Heart, Breast, Endothelial, Lymph Node, B Cells

Publications for Lymphangiectasis

Articles related to Lymphangiectasis:

(show top 50) (show all 330)
# Title Authors Year
1
Acquired Cutaneous Lymphangiectasia Secondary to Cervical Cancer Treatment. ( 30289772 )
2018
2
Endoscopic Ultrasound-guided Cytodiagnosis of Adrenal Histoplasmosis with Reversible CD4 T-Lymphocytopenia and Jejunal Lymphangiectasia. ( 29643659 )
2018
3
Intestinal lymphangiectasia: a rare cause of intussusception in an adolescent. ( 30322285 )
2018
4
An additional case of Hennekam lymphangiectasia-lymphedema syndrome caused by loss-of-function mutation in ADAMTS3. ( 30450763 )
2018
5
Primary intestinal lymphangiectasia and a review of the current literature. ( 30381277 )
2018
6
Primary Intestinal Lymphangiectasia (Waldmann's disease). ( 30410036 )
2018
7
Lymphangiectasia. ( 29232763 )
2018
8
Unique Case of Postural Acquired Lymphangiectasia of the Scrotum Exacerbated by an Erect Position. ( 29853762 )
2018
9
Lymphaticovenous anastomosis and resection for genital acquired lymphangiectasia (GAL). ( 30327121 )
2018
10
Acquired widespread lymphangiectasia mimicking immunobullous disease: A case report. ( 30327718 )
2018
11
Cutaneous Lymphangiectasia of Genitalia: A Rare Occurrence. ( 30347955 )
2018
12
Acquired Lymphangiectasia of the Scrotum. ( 30413230 )
2018
13
Novel Magnified Single-Balloon Enteroscopy Enables Observation of Jejunal White Spots Associated with Lymphangiectasia. ( 30466073 )
2018
14
Deterioration of duodenal lymphangiectasia after radiotherapy for gastric MALT lymphoma. ( 28798810 )
2017
15
Congenital pulmonary lymphangiectasia and early mortality after stage 1 reconstruction procedures. ( 28287055 )
2017
16
Congenital Pulmonary Lymphangiectasia: A Disorder not only of Fetoneonates. ( 28718185 )
2017
17
Congenital pulmonary lymphangiectasia and chylothorax - a case series. ( 30248723 )
2017
18
Surgical Drainage of Lymphangiectasia Haemorrhagica Conjunctivae. ( 27684459 )
2017
19
Cutaneous Lymphangiectasia in Systemic Sclerosis. ( 27860469 )
2017
20
Scrotal lymphangiectasia following scrofuloderma. ( 28272061 )
2017
21
Atypical Conjunctival Lymphangiectasia Presenting as Conjunctival Horn. ( 28329886 )
2017
22
Renal lymphangiectasia treated with percutaneous drainage and sclerotherapy. ( 28598807 )
2017
23
Diagnosis of secondary pulmonary lymphangiectasia in congenital heart disease: a novel role for chest ultrasound and prognostic implications. ( 28631156 )
2017
24
Role of CT scan in diagnosis of renal lymphangiectasia: our single-center experience. ( 28639460 )
2017
25
Lymphovenous Anastomosis and Secondary Resection for Noonan Syndrome with Vulvar Lymphangiectasia. ( 27622088 )
2016
26
Retroperitoneal lymphangiectasia. ( 24889353 )
2016
27
Acquired lymphoedema and cutaneous lymphangiectasia of abdominal skin following bilateral breast reduction and abdominoplasty. ( 26113117 )
2016
28
Intestinal lymphangiectasia in children. A favorable response to dietary modifications. ( 26837404 )
2016
29
Renal lymphangiectasia: One disease, many names! ( 26937083 )
2016
30
Successful Treatment of Conjunctival Lymphangiectasia With Subconjunctival Injection of Bevacizumab. ( 27227398 )
2016
31
Successful Treatment of Acquired Balanic Lymphangiectasia Following Circumcision Using 2,940-nm Erbium-Doped Yttrium Aluminium Garnet Laser. ( 27243132 )
2016
32
Large retroperitoneal filarial lymphangiectasia. ( 27257331 )
2016
33
Intestinal Lymphangiectasia: Insights on Management and Literature Review. ( 27440277 )
2016
34
Bilateral renal lymphangiectasia-an unusual cause of abdominal distension and flank pain in a child. ( 27709085 )
2016
35
Bilateral Renal Lymphangiectasia. ( 27790546 )
2016
36
Renal lymphangiectasia: know it in order to diagnose it. ( 28057970 )
2016
37
Severe primary pulmonary lymphangiectasis in a premature infant: management and follow up to early childhood. ( 25711257 )
2015
38
Reply to scurry et Al.: vulvar lymphangiectasis, an indicator of lymph stasis, is an authentic sign of abnormal histopathology in labiaplasty specimens. ( 25811280 )
2015
39
Acquired lymphangiectasis following surgery and radiotherapy of breast cancer. ( 25657438 )
2015
40
Primary intestinal lymphangiectasia with generalized warts. ( 26217101 )
2015
41
Noonan Syndrome Complicated by Primary Pulmonary Lymphangiectasia. ( 26803093 )
2015
42
Pediatric lymphangiectasia: an imaging spectrum. ( 25301383 )
2015
43
Acquired lymphangiectasia of the vulva. ( 25706522 )
2015
44
Bilateral Renal Lymphangiectasia in a Thirty-two-Year-Old Woman. ( 25738118 )
2015
45
What is your diagnosis? acquired lymphangiectasia. ( 25750966 )
2015
46
Bilateral renal lymphangiectasia: radiological findings by ultrasound, computed tomography, and magnetic resonance imaging. ( 25806141 )
2015
47
Conjunctival Lymphangiectasia Imaged with Anterior Segment OCT. ( 25902083 )
2015
48
Renal Lymphangiectasia: A Curious Cause of Pleural Effusion. ( 26858768 )
2015
49
Congenital generalized lymphangiectasia: a rare developmental disorder for non-immune fetal hydrops. ( 26894043 )
2015
50
Acquired Lymphangiectasia of the Breast After Breast Conserving Surgery. ( 27011587 )
2015

Variations for Lymphangiectasis

Expression for Lymphangiectasis

Search GEO for disease gene expression data for Lymphangiectasis.

Pathways for Lymphangiectasis

Pathways related to Lymphangiectasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.44 ACTC1 VIM
2 10.48 ACTC1 VIM

GO Terms for Lymphangiectasis

Cellular components related to Lymphangiectasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 focal adhesion GO:0005925 8.62 ACTC1 VIM

Biological processes related to Lymphangiectasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 8.96 ACTC1 VIM
2 muscle filament sliding GO:0030049 8.62 ACTC1 VIM

Sources for Lymphangiectasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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