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MCID: LYM035
MIFTS: 30

Lymphangiectasis

Categories: Rare diseases, Immune diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Lymphangiectasis

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MalaCards integrated aliases for Lymphangiectasis:

Name: Lymphangiectasis 53 73
Lymphangiectasia 53

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Immune diseases
See all MalaCards categories (disease lists)


External Ids:

UMLS 73 C0024214
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Summaries for Lymphangiectasis

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MalaCards based summary : Lymphangiectasis, also known as lymphangiectasia, is related to mullerian derivatives, persistence of, with lymphangiectasia and postaxial polydactyly and lymphangiectasia, pulmonary, congenital. An important gene associated with Lymphangiectasis is ACTC1 (Actin, Alpha, Cardiac Muscle 1), and among its related pathways/superpathways are Cytoskeletal Signaling and Striated Muscle Contraction. The drugs Miconazole and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and endothelial.

Wikipedia : 76 Lymphangiectasia is a pathologic dilation of lymph vessels. When it occurs in the intestines of dogs,... more...

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Related Diseases for Lymphangiectasis

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Diseases related to Lymphangiectasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 mullerian derivatives, persistence of, with lymphangiectasia and postaxial polydactyly 11.2
2 lymphangiectasia, pulmonary, congenital 11.0
3 hennekam syndrome 10.9
4 lymphangiectasia, intestinal 10.9
5 hennekam lymphangiectasia-lymphedema syndrome 1 10.9
6 primary intestinal lymphangiectasia 10.9
7 lymphangioma 10.0
8 glomangiomyoma 9.9 ACTC1 VIM
9 angiolipoma 9.9 ACTC1 VIM
10 intravascular papillary endothelial hyperplasia 9.9 ACTC1 VIM
11 spindle cell lipoma 9.9 ACTC1 VIM
12 parachordoma 9.9 ACTC1 VIM
13 ossifying fibromyxoid tumor 9.9 ACTC1 VIM
14 epithelioid leiomyosarcoma 9.9 ACTC1 VIM
15 syringocystadenoma papilliferum 9.8 ACTC1 VIM
16 benign metastasizing leiomyoma 9.8 ACTC1 VIM
17 adenofibroma 9.8 ACTC1 VIM
18 congenital fibrosarcoma 9.8 ACTC1 VIM
19 pericarditis 9.8
20 peritonitis 9.8
21 breast cancer 9.8
22 osteomalacia 9.8
23 protein-losing enteropathy 9.8
24 noonan syndrome 1 9.8
25 constrictive pericarditis 9.8
26 pseudo-turner syndrome 9.8
27 angiocentric glioma 9.8 ACTC1 VIM
28 pleomorphic liposarcoma 9.8 ACTC1 VIM
29 perivascular epithelioid cell tumor 9.8 ACTC1 VIM
30 reticulum cell sarcoma 9.8 ACTC1 VIM
31 cutaneous fibrous histiocytoma 9.8 ACTC1 VIM
32 glomus tumor 9.8 ACTC1 VIM
33 spindle cell sarcoma 9.8 ACTC1 VIM
34 pseudosarcomatous fibromatosis 9.8 ACTC1 VIM
35 dendritic cell tumor 9.8 ACTC1 VIM
36 rhabdoid cancer 9.8 ACTC1 VIM
37 smooth muscle tumor 9.8 ACTC1 VIM
38 hemangiopericytoma, malignant 9.8 ACTC1 VIM
39 granulosa cell tumor of the ovary 9.8 ACTC1 VIM
40 polymorphous low-grade adenocarcinoma 9.8 ACTC1 VIM
41 infantile myofibromatosis 9.8 ACTC1 VIM
42 chondromyxoid fibroma 9.8 ACTC1 VIM
43 malignant fibroxanthoma 9.7 ACTC1 VIM
44 fasciitis 9.7 ACTC1 VIM
45 glomangioma 9.7 ACTC1 VIM
46 fibromatosis 9.7 ACTC1 VIM
47 myoepithelioma 9.7 ACTC1 VIM
48 spindle cell carcinoma 9.7 ACTC1 VIM
49 wilson-mikity syndrome 9.7
50 gonadal agenesis 9.7

Graphical network of the top 20 diseases related to Lymphangiectasis:



Diseases related to Lymphangiectasis
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Symptoms & Phenotypes for Lymphangiectasis

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Drugs & Therapeutics for Lymphangiectasis

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Drugs for Lymphangiectasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
2
Everolimus Approved Phase 2 159351-69-6 6442177
3
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
4 Anti-Bacterial Agents Phase 2
5 Antibiotics, Antitubercular Phase 2
6 Immunosuppressive Agents Phase 2
7 Anti-Infective Agents Phase 2
8 Antifungal Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies Active, not recruiting NCT00975819 Phase 2 sirolimus
2 Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders Recruiting NCT02156115
3 International Lymphatic Disease and Lymphedema Registry Recruiting NCT01336790

Search NIH Clinical Center for Lymphangiectasis

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Genetic Tests for Lymphangiectasis

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Anatomical Context for Lymphangiectasis

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MalaCards organs/tissues related to Lymphangiectasis:

41
Lung, Breast, Endothelial, Testes, Kidney, Spleen, Heart
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Publications for Lymphangiectasis

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Articles related to Lymphangiectasis:

(show top 50) (show all 122)
# Title Authors Year
1
Severe primary pulmonary lymphangiectasis in a premature infant: management and follow up to early childhood. ( 25711257 )
2015
2
Reply to scurry et Al.: vulvar lymphangiectasis, an indicator of lymph stasis, is an authentic sign of abnormal histopathology in labiaplasty specimens. ( 25811280 )
2015
3
Acquired lymphangiectasis following surgery and radiotherapy of breast cancer. ( 25657438 )
2015
4
Congenital pulmonary lymphangiectasis. ( 24997116 )
2014
5
A case of transient lymphangiectasis of the penis. ( 24846179 )
2014
6
Mildly progressive pulmonary lymphangiectasis diagnosed in a young adult. ( 24684358 )
2014
7
Removal of lymphangiectasis using high-frequency radio wave electrosurgery. ( 22968357 )
2013
8
Firm cord-like band over the penile shaft. Benign transient lymphangiectasis of the penis. ( 22182374 )
2012
9
[Congenital pulmonary lymphangiectasis: an unusual cause of respiratory distress in neonates]. ( 22381667 )
2012
10
Intestinal lymphangiectasis and lipidosis in rats following subchronic exposure to indole-3-carbinol via oral gavage. ( 22328411 )
2012
11
Osteomalacia and osteoporosis associated with primary intestinal lymphangiectasis. ( 22800909 )
2012
12
Conjunctival Lymphangiectasis. ( 20429497 )
2010
13
Congenital pulmonary lymphangiectasis: report of an autopsy case masquerading as pulmonary interstitial emphysema. ( 20399027 )
2010
14
Lymphangiectasis of lower limb: A rare challenging case. ( 20368868 )
2009
15
Lymphangiectasis of lower limb. ( 20368869 )
2009
16
Combination technique of radiofrequency ablation with sclerotherapy in acquired lymphangiectasis of the vulva. ( 20300370 )
2009
17
Outcome of children with pulmonary lymphangiectasis. ( 19330773 )
2009
18
In-transit metastasis from melanoma presenting as lymphangiectasis: a case report. ( 19842575 )
2009
19
Congenital pulmonary lymphangiectasis. ( 19172338 )
2009
20
Osteomalacia in a patient with primary intestinal lymphangiectasis (Waldmann's disease). ( 17900962 )
2008
21
The Multi-Detector CT findings of giant abdominal lymphangiectasis mimicking a mesenteric cystic mass in a patient with midgut volvulus. ( 25610038 )
2008
22
Clinico-pathological characteristics of congenital pulmonary lymphangiectasis: report of two cases. ( 17728521 )
2007
23
An adult with a cord round the neck: benign transient lymphangiectasis of the penis. ( 17921623 )
2007
24
Endothelial, inducible and neuronal nitric oxide synthase in congenital pulmonary lymphangiectasis. ( 16772393 )
2006
25
Congenital pulmonary lymphangiectasis sequence: a rare, heterogeneous, and lethal etiology for prenatal pleural effusion. ( 16941717 )
2006
26
Pulmonary lymphangiectasis in an asymptomatic adult. ( 16179818 )
2006
27
Unilobar congenital pulmonary lymphangiectasis mimicking congenital lobar emphysema: an underestimated presentation? ( 15136998 )
2004
28
Autopsy case of congenital pulmonary lymphangiectasis. ( 15189509 )
2004
29
Acquired lymphangiectasis after breast conservation treatment for breast cancer: report of a case. ( 15347491 )
2004
30
Primary pulmonary lymphangiectasis in a premature infant: resolution following intensive care. ( 12687599 )
2003
31
Congenital pulmonary lymphangiectasis. ( 14686556 )
2003
32
Surgical management of conjunctival lymphangiectasis by conjunctival resection. ( 14516817 )
2003
33
Chylous reflux into localized pulmonary lymphangiectasis. ( 12173851 )
2002
34
Thoracic lymphangiectasis presenting with chyloptysis and bronchial cast expectoration. ( 12522631 )
2002
35
A case of cutaneous lymphangiectasis secondary to breast cancer treatment. ( 11903671 )
2001
36
Persistence of MA1llerian derivatives and intestinal lymphangiectasis in two newborn brothers: confirmation of the Urioste syndrome. ( 11746031 )
2001
37
Lymphangiectasis with iniencephaly. ( 11844186 )
2001
38
Thoracic lymphangiomas, lymphangiectasis, lymphangiomatosis, and lymphatic dysplasia syndrome. ( 10712360 )
2000
39
Lymphangioma and congenital pulmonary lymphangiectasis: a histologic, immunohistochemical, and clinicopathologic comparison. ( 10392631 )
1999
40
Treatment of acquired cutaneous lymphangiectasis of the thigh and vulva with a carbon dioxide laser. ( 10430005 )
1999
41
Acquired lymphangiectasis. ( 9932832 )
1999
42
Congenital unilobar pulmonary lymphangiectasis. ( 10230931 )
1999
43
Cutaneous lymphangiectasis: treatment with sclerotherapy. ( 9462778 )
1998
44
Acquired lymphangiectasis following mastectomy and radiation therapy--report of a case and review of the literature. ( 8894426 )
1996
45
Benign transient lymphangiectasis. ( 8854157 )
1996
46
[Congenital pulmonary lymphangiectasis]. ( 7788732 )
1995
47
Unilateral lymphangiectasis of the kidney: an unusual cause of renal enlargement in an infant. ( 7815616 )
1995
48
Progressive lymphangiectasis and recurrent chylothorax in a dog after thoracic duct ligation. ( 7559046 )
1995
49
Congenital pulmonary lymphangiectasis presenting as a unilateral hyperlucent lung. ( 8181508 )
1994
50
Pancreatic lymphangiectasis. ( 7942757 )
1994
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Variations for Lymphangiectasis

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Expression for Lymphangiectasis

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Search GEO for disease gene expression data for Lymphangiectasis.
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Pathways for Lymphangiectasis

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Pathways related to Lymphangiectasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cytoskeletal Signaling 4
11.44 ACTC1 VIM
2
Striated Muscle Contraction 1 66
10.48 ACTC1 VIM
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GO Terms for Lymphangiectasis

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Cellular components related to Lymphangiectasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 focal adhesion GO:0005925 8.62 ACTC1 VIM

Biological processes related to Lymphangiectasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 8.96 ACTC1 VIM
2 muscle filament sliding GO:0030049 8.62 ACTC1 VIM
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Sources for Lymphangiectasis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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