MCID: LYM035
MIFTS: 30

Lymphangiectasis

Categories: Gastrointestinal diseases, Immune diseases, Rare diseases

Aliases & Classifications for Lymphangiectasis

MalaCards integrated aliases for Lymphangiectasis:

Name: Lymphangiectasis 20 17 70
Lymphangiectasia 20

Classifications:



External Ids:

UMLS 70 C0024214

Summaries for Lymphangiectasis

MalaCards based summary : Lymphangiectasis, also known as lymphangiectasia, is related to lymphangioma and hemangioma. An important gene associated with Lymphangiectasis is ACTC1 (Actin Alpha Cardiac Muscle 1), and among its related pathways/superpathways are Cytoskeletal Signaling and Striated Muscle Contraction. The drug Complement System Proteins has been mentioned in the context of this disorder. Affiliated tissues include small intestine, breast and endothelial.

Wikipedia : 73 Lymphangiectasia, also known as "lymphangiectasis", is a pathologic dilation of lymph vessels. When it... more...

Related Diseases for Lymphangiectasis

Diseases related to Lymphangiectasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 394)
# Related Disease Score Top Affiliating Genes
1 lymphangioma 30.1 VIM ACTC1
2 hemangioma 29.4 VIM ACTC1
3 angiomyolipoma 29.3 VIM ACTC1
4 rhabdomyosarcoma 28.8 VIM ACTC1
5 hennekam lymphangiectasia-lymphedema syndrome 2 11.6
6 hennekam lymphangiectasia-lymphedema syndrome 3 11.5
7 aplasia cutis congenita with intestinal lymphangiectasia 11.5
8 lymphangiectasia, pulmonary, congenital 11.1
9 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 11.0
10 lymphatic malformation 6 11.0
11 primary intestinal lymphangiectasia 11.0
12 mullerian derivatives, persistence of, with lymphangiectasia and postaxial polydactyly 11.0
13 lymphangiectasia, intestinal 11.0
14 hennekam lymphangiectasia-lymphedema syndrome 1 10.9
15 agammaglobulinemia 10.4
16 protein-losing enteropathy 10.3
17 rare lymphatic malformation 10.3
18 hereditary lymphedema i 10.1
19 nephrotic syndrome 10.1
20 yellow nail syndrome 10.1
21 b-cell lymphoma 10.1
22 noonan syndrome 1 10.1
23 elephantiasis 10.1
24 lymphangitis 10.1
25 pseudo-turner syndrome 10.1
26 hypertelorism 10.0
27 filariasis 10.0
28 cryptorchidism, unilateral or bilateral 10.0
29 cyanosis, transient neonatal 10.0
30 pulmonary interstitial emphysema 10.0
31 respiratory failure 10.0
32 constrictive pericarditis 10.0
33 diarrhea 10.0
34 pneumothorax 10.0
35 pericarditis 10.0
36 cellulitis 10.0
37 lymphopenia 10.0
38 hydronephrosis 10.0
39 tuberous sclerosis 10.0
40 intestinal obstruction 10.0
41 amyloidosis 10.0
42 immune hydrops fetalis 10.0
43 aplasia cutis congenita, nonsyndromic 9.9
44 intussusception 9.9
45 scleroderma, familial progressive 9.9
46 tuberous sclerosis 1 9.9
47 immune deficiency disease 9.9
48 lymphangioleiomyomatosis 9.9
49 proteinuria, chronic benign 9.9
50 crohn's colitis 9.9

Graphical network of the top 20 diseases related to Lymphangiectasis:



Diseases related to Lymphangiectasis

Symptoms & Phenotypes for Lymphangiectasis

Drugs & Therapeutics for Lymphangiectasis

Drugs for Lymphangiectasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Complement System Proteins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Transcriptome and Metabolic Analyses of CHAPLE Disease Patients With or Without Eculizumab Treatment Recruiting NCT03950804 Eculizumab Injection
2 Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders Recruiting NCT02156115

Search NIH Clinical Center for Lymphangiectasis

Genetic Tests for Lymphangiectasis

Anatomical Context for Lymphangiectasis

MalaCards organs/tissues related to Lymphangiectasis:

40
Small Intestine, Breast, Endothelial, Colon, Lymph Node, Pancreas, Spleen

Publications for Lymphangiectasis

Articles related to Lymphangiectasis:

(show top 50) (show all 1474)
# Title Authors PMID Year
1
[Intestinal lymphangiectasia in a patient with Sanfilippo B syndrome]. 61
33749204 2021
2
Hennekam lymphangiectasia syndrome: A rare case of primary lymphedema. 61
33769747 2021
3
The diagnostic value of capsule endoscopy in children with intestinal lymphangiectasia. 61
33733798 2021
4
Posttransplant Renal Lymphangiectasia Presents Differently From Native Kidneys and Warrants Attention. 61
33317390 2021
5
Vulval lymphangiectasia in pregnancy-a rare case report. 61
33779006 2021
6
Dermatochalasis Through Decades: A Histopathologic Study. 61
33555688 2021
7
Long-term endoscopic findings in pediatric primary intestinal lymphangiectasia. 61
33598292 2021
8
DUODENAL LYMPHANGIECTASIAS - THE FIRST SIGN OF PANCREATIC ADENOCARCINOMA. 61
33569966 2021
9
Capsule Retention Caused by Cryptogenic Multifocal Ulcerous Stenosing Enteritis. 61
33562987 2021
10
Lymphangioma Formation Following Hyaluronic Acid Injection for Lip Augmentation. 61
33654610 2021
11
Retroperitoneal Lymphangioma in Adult: A Case Report. 61
33397879 2021
12
Scrotal Lymphangiectasia with Penile Elephantiasis in Underlying Lymphatic Filariasis-Challenging the Diagnostic Mind! A Case Report. 61
33401419 2021
13
Individual approach for treatment of primary intestinal lymphangiectasia in children: single-center experience and review of the literature. 61
33407260 2021
14
Primary Intestinal Lymphangiectasia: Diagnostic Accuracy of 99mTc-Labeled Human Serum Albumin Nanocolloid SPECT/CT Before Biopsy. 61
33031249 2021
15
Intestinal Lymphangiectasia Associated With Refractory Ascites in a Cirrhosis Patient. 61
33564554 2021
16
Dietary and Nutritional Approaches to the Management of Chronic Enteropathy in Dogs and Cats. 61
33131914 2021
17
Patterns of Mycobacterium avium-intracellulare complex infection in duodenal endoscopic biopsies in HIV/AIDS patients. 61
33069083 2020
18
Renal Lymphangiectasia in a Pediatric Patient. 61
32589505 2020
19
Acquired lymphangiectasia: a rare mimic of genital warts. 61
33423429 2020
20
A case of "misplaced" Tritrichomonas foetus infection in a dog in Northern Italy. 61
33308716 2020
21
Primary intestinal lymphangiectasia in an adult patient: A case report and review of literature. 61
33505146 2020
22
Primary pulmonary lymphangiectasia in Noonan syndrome: apropos of an extremely rare manifestation and a brief literature review. 61
33305557 2020
23
Chronic diarrhea with white colon: primary intestinal lymphangiectasia. 61
32330275 2020
24
Pleural effusion and ascites in extrarenal lymphangiectasia caused by post-biopsy hematoma: A case report. 61
33392314 2020
25
A pilot study on the effect of fat loading on the gastrointestinal tract of healthy dogs. 61
33035376 2020
26
Imaging of fetal lymphangiectasias: prenatal and postnatal imaging findings. 61
33252755 2020
27
A case of Heck's disease with primary intestinal lymphangiectasia treated with imiquimod. 61
32830787 2020
28
Primary intestinal lymphangiectasia in children: A review. 61
32463559 2020
29
Oral lymphangiectasia and gastrointestinal Crohn disease. 61
32761835 2020
30
Predictors of iron-deficiency anemia in primary care older adults: a real-world European multi-country longitudinal study. 61
31893385 2020
31
Enhanced Collagen Deposition in the Duodenum of Patients with Hyaline Fibromatosis Syndrome and Protein Losing Enteropathy. 61
33147779 2020
32
Conjunctival lymphangiectasia as a biomarker of severe systemic disease in Ser77Tyr hereditary transthyretin amyloidosis. 61
31949094 2020
33
Renal Lymphangiectasia: An Unusual Mimicker of Cystic Renal Disease - A Case Series and Literature Review. 61
33178504 2020
34
Refractory hypertension due to unilateral renal lymphangiectasia: An uncommon case with a surgical solution. 61
32322527 2020
35
Contrast enhanced ultrasound for the diagnosis of bilateral renal lymphangiectasia: literature review and contrast enhanced ultrasound findings. 61
32886346 2020
36
Primary intestinal lymphangiectasia diagnosed by video capsule endoscopy in a patient with immunodeficiency presenting with Morganella morganii bacteraemia. 61
32928820 2020
37
A homozygous variant in growth and differentiation factor 2 (GDF2) may cause lymphatic dysplasia with hydrothorax and nonimmune hydrops fetalis. 61
32618121 2020
38
Intestinal lymphangiectasia in a 3-month-old girl: A case report of Hennekam syndrome caused by CCBE1 mutation. 61
32629717 2020
39
Magnetic Resonance Lymphangiography. 61
32471538 2020
40
Risk stratification of patients with hypoplastic left heart syndrome and intact atrial septum using fetal MRI and echocardiography. 61
32406345 2020
41
[Variant analysis of CCBE1 gene in a case of Hennekam lymphangiectasia-lymphedema syndrome type 1]. 61
32472549 2020
42
Protein-Losing Enteropathy in Primary Lymphangiectasia. 61
32676544 2020
43
Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow. 61
32182215 2020
44
Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage. 61
32572022 2020
45
A familial case of alveolar capillary dysplasia with misalignment of the pulmonary veins: the clinicopathological features and unusual glomeruloid endothelial proliferation. 61
32386508 2020
46
Tuberous sclerosis complex presenting as primary intestinal lymphangiectasia: A case report. 61
32518792 2020
47
Orofacial granulomatosis presenting with the unusual sign of lymphangiectasia successfully treated with isotretinoin. 61
31769006 2020
48
Successful thoracic duct embolisation in a child with recurrent massive pericardial effusion diagnosed as a lymphatic anomaly. 61
32090718 2020
49
Vaginal discharge caused by lymphatic malformation identified by lymphoscintigraphy combined with T2-weighted magnetic resonance imaging. 61
32025595 2020
50
Primary Chylous Lymphangiectasia of Female Genitalia. 61
32180600 2020

Variations for Lymphangiectasis

Expression for Lymphangiectasis

Search GEO for disease gene expression data for Lymphangiectasis.

Pathways for Lymphangiectasis

Pathways related to Lymphangiectasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.44 VIM ACTC1
2 10.48 VIM ACTC1

GO Terms for Lymphangiectasis

Cellular components related to Lymphangiectasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 focal adhesion GO:0005925 8.62 VIM ACTC1

Biological processes related to Lymphangiectasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 8.96 VIM ACTC1
2 muscle filament sliding GO:0030049 8.62 VIM ACTC1

Sources for Lymphangiectasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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