MCID: LYM022
MIFTS: 49

Lymphangioma

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Lymphangioma

MalaCards integrated aliases for Lymphangioma:

Name: Lymphangioma 12 37 29 55 44 15 73
Congenital Lymphangioma 12
Benign Lymphangioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1475
ICD10 33 D18.1
ICD9CM 35 228.1
MeSH 44 D008202
NCIt 50 C8965
SNOMED-CT 68 69044001 93168006
KEGG 37 H01471
UMLS 73 C0024221

Summaries for Lymphangioma

MalaCards based summary : Lymphangioma, also known as congenital lymphangioma, is related to orbital lymphangioma and lymphatic malformations. An important gene associated with Lymphangioma is FLT4 (Fms Related Tyrosine Kinase 4), and among its related pathways/superpathways are Nanog in Mammalian ESC Pluripotency and Focal Adhesion. The drugs Picibanil and Octreotide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, tongue and lymph node, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Lymphangiomas are malformations of the lymphatic system characterized by lesions that are thin-walled... more...

Related Diseases for Lymphangioma

Diseases related to Lymphangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 248)
# Related Disease Score Top Affiliating Genes
1 orbital lymphangioma 33.6 FLT4 PDPN
2 lymphatic malformations 33.4 FLT4 PROX1
3 capillary lymphangioma 33.4 HBA1 PROX1
4 infantile myofibromatosis 31.6 ACTC1 VIM
5 kaposiform hemangioendothelioma 30.5 FLT4 KDR PROX1
6 malignant hemangioma 30.3 FLT4 KDR
7 lymphangiectasis 30.3 ACTC1 VIM
8 kaposi sarcoma 30.3 IFNA2 KDR VEGFA
9 hemangioendothelioma 30.3 FLT4 KDR
10 hemangioma 30.3 ACTC1 FLT4 KDR PDPN PROX1 VEGFA
11 epithelioid hemangioendothelioma 30.1 KDR VEGFA
12 gorham's disease 30.0 FLT4 IFNA2 VEGFC
13 glomus tumor 30.0 ACTC1 VIM
14 hydrocele 29.8 FLT4 VEGFA
15 congenital lymphedema 29.8 FLT4 PDPN VEGFC
16 spindle cell sarcoma 29.7 ACTC1 VIM
17 gastrointestinal stromal tumor 29.5 ACTC1 VEGFA VIM
18 alveoli adenoma 29.4 FLT4 HBA1 PROX1
19 lymphangiosarcoma 29.2 FLT4 HBA1 PDPN PROX1 VEGFA VEGFC
20 cystic lymphangioma 12.5
21 abdominal cystic lymphangioma 12.5
22 microcystic lymphatic malformation 12.2
23 cavernous lymphangioma 12.2
24 colonic lymphangioma 12.2
25 primary laryngeal lymphangioma 12.1
26 nuchal bleb, familial 12.0
27 diffuse lymphatic malformation 11.6
28 cobb syndrome 11.5
29 lymphangiomatosis 11.4
30 mixed cystic lymphatic malformation 11.3
31 multiple enchondromatosis, maffucci type 11.0
32 cavernous hemangioma 10.5
33 hemangioma-thrombocytopenia syndrome 10.4
34 retiform hemangioendothelioma 10.4
35 sarcoma 10.3
36 mucinous cystadenocarcinoma of the pancreas 10.2 PDPN VEGFC
37 malignant epithelioid hemangioendothelioma 10.2 FLT4 KDR
38 hereditary lymphedema 10.2 FLT4 VEGFC
39 hemangioma, capillary infantile 10.2 FLT4 KDR
40 hemifacial spasm 10.2 FLT4 VEGFA
41 intussusception 10.2
42 infiltrating angiolipoma 10.2 VEGFA VEGFC
43 angiokeratoma circumscriptum 10.2 KDR VEGFA
44 discoid lupus erythematosus 10.2 IFNA2 PDPN
45 radiation proctitis 10.2 KDR VEGFA
46 klippel-trenaunay-weber syndrome 10.2
47 pulmonary vein stenosis 10.2 ACTC1 KDR
48 miliaria 10.2 HBA1 PDPN
49 leukostasis 10.1 KDR VEGFA
50 pyogenic granuloma 10.1 ACTC1 VEGFA

Graphical network of the top 20 diseases related to Lymphangioma:



Diseases related to Lymphangioma

Symptoms & Phenotypes for Lymphangioma

MGI Mouse Phenotypes related to Lymphangioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 ACTC1 FLT4 KDR PDPN PROX1 SERPINF1
2 homeostasis/metabolism MP:0005376 9.76 ACTC1 FLT4 KDR PDPN PROX1 VEGFA
3 immune system MP:0005387 9.56 FLT4 KDR PDPN PROX1 SERPINF1 VEGFA
4 muscle MP:0005369 9.17 ACTC1 FLT4 KDR PDPN PROX1 VEGFA

Drugs & Therapeutics for Lymphangioma

Drugs for Lymphangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Picibanil Phase 4,Phase 2,Phase 3
2
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
3
Everolimus Approved Phase 2 159351-69-6 6442177
4
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
5
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
6
Citric Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2,Phase 2 77-92-9 311
7 Antineoplastic Agents, Hormonal Phase 2
8 Gastrointestinal Agents Phase 2
9 Phosphodiesterase 5 Inhibitors Phase 1, Phase 2,Phase 2
10 Phosphodiesterase Inhibitors Phase 1, Phase 2,Phase 2
11 Citrate Phase 1, Phase 2,Phase 2
12 Sildenafil Citrate Phase 1, Phase 2,Phase 2 171599-83-0
13 Vasodilator Agents Phase 1, Phase 2,Phase 2
14 Anti-Bacterial Agents Phase 2
15 Antibiotics, Antitubercular Phase 2
16 Immunosuppressive Agents Phase 2
17 Anti-Infective Agents Phase 2
18 Immunologic Factors Phase 2
19 Antifungal Agents Phase 2
20
Selenium Approved, Investigational, Vet_approved Phase 1 7782-49-2
21
Marimastat Investigational Phase 1 154039-60-8 119031
22 Antioxidants Phase 1
23 Trace Elements Phase 1
24 Protective Agents Phase 1
25 Micronutrients Phase 1
26
Pancrelipase Approved, Investigational 53608-75-6
27 Anesthetics Not Applicable
28 pancreatin

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 OK432 (Picibanil) in the Treatment of Lymphatic Malformations Completed NCT03427619 Phase 4 OK432
2 Study of Picibanil (OK432) Sclerotherapy in Children With Macrocystic Lymphatic Malformations Completed NCT00010452 Phase 2, Phase 3 picibanil
3 Octreotide VS Placebo in Prevention of Salivary Fistulae After Post Radiation Salvage Surgery Unknown status NCT02437825 Phase 2 octreotide
4 A Study to Evaluate Sildenafil for the Treatment of Lymphatic Malformations Completed NCT01290484 Phase 1, Phase 2 Sildenafil
5 Sildenafil for the Treatment of Lymphatic Malformations Recruiting NCT02335242 Phase 2 Sildenafil 20 mg tablets
6 Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic Malformations Recruiting NCT03243019 Phase 2 rapamycin
7 Trial of Taselisib in Overgrowth Recruiting NCT03290092 Phase 1, Phase 2 Taselisib (GDC0032);Taselisib (GDC0032)
8 Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies Active, not recruiting NCT00975819 Phase 2 sirolimus
9 Phase I Drug Trial for S/E of Marimastat in Disabling Malformations When no Other Options. Completed NCT00261391 Phase 1 Marimastat
10 Selenium in the Treatment of Complicated Lymphatic Malformations Terminated NCT01212965 Phase 1 Selenium
11 Airway Vascular Lesions Completed NCT00866827
12 Imaging of Lymphatic Anomalies Completed NCT02744027 Not Applicable
13 Diagnosis of Hemangiomas and Vascular Malformations Completed NCT00577213
14 Lymphatic Anomalies Registry Recruiting NCT02399527
15 AVAST Anomalies Vasculaires Associées au Syndrome de Turner (Vascular Abnormalities Associated With Turner Syndrome) Recruiting NCT02250456
16 Development of a Specific Scale of Life'Quality for Children With Low-flow Vascular Malformations Recruiting NCT03440827 Not Applicable
17 Registry for Vascular Anomalies Associated With Coagulopathy Recruiting NCT00576888
18 Imaging Lymphatic Function in Normal Subjects and in Persons With Lymphatic Disorders Enrolling by invitation NCT00833599 NIRFLI with ICG
19 Needle-based Confocal Laser Endomicroscopy on Pancreatic Cystic Lesions Terminated NCT02494388

Search NIH Clinical Center for Lymphangioma

Cochrane evidence based reviews: lymphangioma

Genetic Tests for Lymphangioma

Genetic tests related to Lymphangioma:

# Genetic test Affiliating Genes
1 Lymphangioma 29

Anatomical Context for Lymphangioma

MalaCards organs/tissues related to Lymphangioma:

41
Pancreas, Tongue, Lymph Node, Colon, Spleen, Breast, Ovary

Publications for Lymphangioma

Articles related to Lymphangioma:

(show top 50) (show all 1295)
# Title Authors Year
1
Giant cystic lymphangioma of adrenal gland: A case report and review of the literature. ( 30306048 )
2019
2
Genital Warts, Lymphangioma, and Treatment with Imiquimod. ( 29803364 )
2018
3
A rare cause of small-bowel bleeding: haemorrhagic small-bowel lymphangioma diagnosed by antegrade double-balloon enteroscopy. ( 29351701 )
2018
4
Ileal Cystic Lymphangioma presenting with Acute Appendicitis. ( 29386763 )
2018
5
Lymphangioma circumscriptum of the tongue: A case with marked hemorrhagic component. ( 29315723 )
2018
6
Lymphangioma Of Tongue. ( 29504356 )
2018
7
Isolated splenic lymphangioma presenting as a huge mass causing anemia and abdominal distension in an adult patient: a case report. ( 29656712 )
2018
8
Acquired lymphangioma circumscriptum of the genitals in an individual with chronic hidradenitis suppurativa. ( 29387752 )
2018
9
Lymphangioma of the Esophagus. ( 29867174 )
2018
10
Lymphangioma circumscriptum of the vulva in a patient with Noonan syndrome. ( 29232041 )
2018
11
Endoscopic submucosal dissection of a giant esophageal lymphangioma. ( 29742767 )
2018
12
An Unusual Aspirate and Microbiopsy of a Pancreas Cyst Diagnostic for Pancreatic Lymphangioma. ( 29574030 )
2018
13
Lymphangioma on 68Ga-NOTA-Evans Blue PET/MRI. ( 29742595 )
2018
14
Lymphangioma circumscriptum treated with combination of Bleomycin sclerotherapy and Radiofrequency ablation. ( 29979907 )
2018
15
Splenic lymphangioma in an adult. ( 29543313 )
2018
16
Percutaneous full endoscopic treatment of cystic lymphangioma of cauda equina: a case report. ( 29658356 )
2018
17
Mediastinal lymphangioma in an adult. ( 29397964 )
2018
18
A young woman with steroid-responsive, IgG4-positive plasma cell-enriched cystic lymphangioma and chylous ascites. ( 29881573 )
2018
19
Sirolimus-induced regression of a large orbital lymphangioma. ( 29405800 )
2018
20
Lymphangioma Circumscriptum Post Radiotherapy for Penile Cancer Treated with COa88 Laser. ( 29782301 )
2018
21
Symptomatic lymphangioma of the adrenal gland: a case report. ( 29876049 )
2018
22
Cystic Lymphangioma: Are Triglycerides Always Measurable? ( 29686910 )
2018
23
Lymphangioma Circumscriptum in Vulva with Klippel-Trenaunay Syndrome. ( 29451158 )
2018
24
Genital Warts, Lymphangioma, and Treatment with Imiquimod. ( 29803363 )
2018
25
Percutaneous therapy of a mediastinal lymphangioma with fibrin glue: case report with clinical success after 4A years. ( 29361923 )
2018
26
A Supernumerary Nipple-Like Clinical Presentation of Lymphangioma Circumscriptum. ( 29796322 )
2018
27
Surgery of multiple lymphangioma in small bowel: a rare case report of chronic gastrointestinal bleeding. ( 29333427 )
2018
28
Retroperitoneal cystic lymphangioma in an adult: A case report. ( 29785367 )
2018
29
A case of extensive acquired progressive lymphangioma. ( 29633311 )
2018
30
Lymphangioma circumscriptum der Vulva bei einer Patientin mit Noonan-Syndrom. ( 29314699 )
2018
31
Spontaneous rupture of a retroperitoneal lymphangioma: Understanding chylous signal with chemical-shift and TrueFISP MR sequence. ( 29910170 )
2018
32
Single-port laparoscopic-assisted resection for a large abdominal cystic lymphangioma: a case report. ( 30105531 )
2018
33
Intra-Abdominal Cystic Lymphangioma. ( 30318372 )
2018
34
Mediastinal Lymphangioma Complicated by Chylopericardium, Tamponade, and Cardiac Arrest Treated with an Endolymphatic Stent Graft. ( 30266225 )
2018
35
A Rare, Giant, Cystic, and Cavernous Lymphangioma Originated from the Stomach in a Young Woman. ( 30039446 )
2018
36
Rare Case of Pancreatic Cystic Lymphangioma. ( 29151529 )
2018
37
Cystic lymphangioma of pancreas: A rare case report and review of the literature. ( 29995757 )
2018
38
Adult Cystic Lymphangioma of the Parotid Gland: An Unwonted Presentation. ( 30034966 )
2018
39
Congenital superior caval vein aneurysm in a newborn with cystic lymphangioma: a rare case report. ( 30043721 )
2018
40
Cystic lymphangioma of nasopharynx in a 54-year-old man - case report. A new histogenetic hypothesis. ( 30173266 )
2018
41
Cystic lymphangioma of the pancreas: a hard diagnostic challenge between pancreatic cystic lesions-review of recent literature. ( 30505770 )
2018
42
Coincidental Lymphangioma and Hemangioma in a Single Lymph Node. ( 30376741 )
2018
43
Jejunal lymphangioma causing intussusception in an adult: An unusual case with review of the literature. ( 30210794 )
2018
44
Palmoplantar lymphangioma-like Kaposi sarcoma. ( 30506813 )
2018
45
Cystic mesenteric lymphangioma: a case report. ( 28419699 )
2018
46
Sonographic findings in two cases of lymphangioma of the mesocolon in adults. ( 28440897 )
2018
47
Axillary lymphangioma in an asymptomatic adult female. ( 28877380 )
2018
48
Vulvar Lymphangioma Circumscriptum Treated With Fractional Ablative Erbium: Yttrium Aluminium Garnet Laser. ( 29077628 )
2018
49
A case of lymphangioma-like mesenteric cysts diagnosed as adenocarcinoma of possible pancreatic origin on EUS-FNA. ( 29113789 )
2018
50
Lymphangioma cavernous of the small bowel mesentery, an infrequent cause of acute abdomen in adult. ( 29479419 )
2018

Variations for Lymphangioma

Expression for Lymphangioma

Search GEO for disease gene expression data for Lymphangioma.

Pathways for Lymphangioma

Pathways related to Lymphangioma according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.04 FLT4 KDR VEGFA VEGFC VIM
2
Show member pathways
12.67 FLT4 KDR VEGFA VEGFC
3
Show member pathways
12.67 FLT4 IFNA2 KDR VEGFA VEGFC
4 12.61 FLT4 IFNA2 VEGFA VEGFC
5 12.52 FLT4 KDR VEGFA VEGFC
6
Show member pathways
12.47 FLT4 KDR VEGFA VEGFC
7
Show member pathways
12.34 FLT4 KDR VEGFA VEGFC
8
Show member pathways
12.13 FLT4 KDR VEGFA VEGFC
9
Show member pathways
12.09 FLT4 KDR VEGFA VEGFC
10
Show member pathways
12.01 FLT4 IFNA2 KDR VEGFC
11
Show member pathways
12 KDR VEGFA VEGFC
12 11.88 FLT4 KDR VEGFC
13 11.68 KDR PROX1 VEGFA VIM
14
Show member pathways
11.42 FLT4 KDR VEGFA VEGFC
15 11.3 FLT4 KDR PDPN PROX1 VEGFC
16 11.17 FLT4 KDR VEGFA
17 11.14 KDR VEGFA
18 10.96 KDR VEGFA
19 10.92 FLT4 VEGFC
20 10.8 FLT4 KDR VEGFC VIM
21 10.77 FLT4 KDR VEGFA VEGFC
22 10.43 VEGFA VEGFC
23
Show member pathways
10.13 FLT4 KDR VEGFA VEGFC

GO Terms for Lymphangioma

Cellular components related to Lymphangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 ACTC1 HBA1 IFNA2 SERPINF1 VEGFA VEGFC
2 extracellular region GO:0005576 9.17 FLT4 HBA1 IFNA2 KDR SERPINF1 VEGFA

Biological processes related to Lymphangioma according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.93 ACTC1 FLT4 KDR PDPN VEGFA
2 positive regulation of cell proliferation GO:0008284 9.89 FLT4 KDR PROX1 VEGFA VEGFC
3 negative regulation of gene expression GO:0010629 9.87 IFNA2 KDR SERPINF1 VEGFA
4 positive regulation of cell migration GO:0030335 9.83 KDR PDPN VEGFA
5 angiogenesis GO:0001525 9.83 FLT4 KDR VEGFA VEGFC
6 positive regulation of angiogenesis GO:0045766 9.81 KDR VEGFA VEGFC
7 regulation of cell shape GO:0008360 9.8 KDR PDPN VEGFA
8 kidney development GO:0001822 9.79 PROX1 SERPINF1 VEGFA
9 lung development GO:0030324 9.77 PDPN PROX1 VEGFA
10 positive regulation of protein phosphorylation GO:0001934 9.73 FLT4 KDR VEGFA VEGFC
11 muscle filament sliding GO:0030049 9.66 ACTC1 VIM
12 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.66 KDR VEGFA
13 positive regulation of focal adhesion assembly GO:0051894 9.65 KDR VEGFA
14 positive regulation of protein autophosphorylation GO:0031954 9.65 VEGFA VEGFC
15 positive regulation of neuroblast proliferation GO:0002052 9.64 VEGFA VEGFC
16 cell migration involved in sprouting angiogenesis GO:0002042 9.64 KDR VEGFA
17 positive regulation of blood vessel endothelial cell migration GO:0043536 9.63 KDR VEGFA VEGFC
18 induction of positive chemotaxis GO:0050930 9.62 VEGFA VEGFC
19 skeletal muscle thin filament assembly GO:0030240 9.62 ACTC1 PROX1
20 lymph vessel development GO:0001945 9.61 FLT4 PROX1
21 positive regulation of positive chemotaxis GO:0050927 9.6 KDR VEGFA
22 positive regulation of cellular component movement GO:0051272 9.58 PDPN VEGFA
23 positive regulation of protein kinase C signaling GO:0090037 9.58 FLT4 VEGFA
24 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.58 FLT4 KDR VEGFA
25 positive regulation of mast cell chemotaxis GO:0060754 9.56 VEGFA VEGFC
26 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.56 FLT4 KDR VEGFA VEGFC
27 sprouting angiogenesis GO:0002040 9.54 FLT4 VEGFA VEGFC
28 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.51 KDR VEGFA
29 lymphangiogenesis GO:0001946 9.5 FLT4 PDPN PROX1
30 actin-mediated cell contraction GO:0070252 9.48 ACTC1 PDPN
31 positive regulation of endothelial cell migration GO:0010595 9.46 FLT4 KDR PROX1 VEGFA
32 positive regulation of endothelial cell proliferation GO:0001938 9.35 FLT4 KDR PROX1 VEGFA VEGFC
33 vascular endothelial growth factor signaling pathway GO:0038084 8.92 FLT4 KDR VEGFA VEGFC
34 multicellular organism development GO:0007275 10.02 KDR PDPN PROX1 SERPINF1 VEGFA VEGFC

Molecular functions related to Lymphangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 9.16 VEGFA VEGFC
2 vascular endothelial growth factor-activated receptor activity GO:0005021 8.96 FLT4 KDR
3 vascular endothelial growth factor receptor 3 binding GO:0043185 8.62 VEGFA VEGFC

Sources for Lymphangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....