MCID: LYM022
MIFTS: 52

Lymphangioma

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Lymphangioma

MalaCards integrated aliases for Lymphangioma:

Name: Lymphangioma 12 37 29 55 44 15 73
Congenital Lymphangioma 12
Benign Lymphangioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1475
ICD10 33 D18.1
ICD9CM 35 228.1
MeSH 44 D008202
NCIt 50 C8965
KEGG 37 H01471
UMLS 73 C0024221

Summaries for Lymphangioma

MalaCards based summary : Lymphangioma, also known as congenital lymphangioma, is related to orbital lymphangioma and lymphatic malformations. An important gene associated with Lymphangioma is FLT4 (Fms Related Tyrosine Kinase 4), and among its related pathways/superpathways are TGF-Beta Pathway and Focal Adhesion. The drugs Picibanil and Octreotide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, tongue and lymph node, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Lymphangiomas are malformations of the lymphatic system characterized by lesions that are thin-walled... more...

Related Diseases for Lymphangioma

Diseases related to Lymphangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 219)
# Related Disease Score Top Affiliating Genes
1 orbital lymphangioma 34.1 FLT4 PDPN
2 lymphatic malformations 33.2 FLT4 PROX1
3 capillary lymphangioma 33.0 HBA1 PROX1
4 hemangioendothelioma 30.7 FLT4 KDR
5 epithelioid hemangioendothelioma 30.3 KDR VEGFA
6 hydrocele 30.1 FLT4 VEGFA
7 gorham's disease 30.1 FLT4 IFNA2 VEGFC
8 kaposiform hemangioendothelioma 30.1 FLT4 KDR PROX1
9 hemangioma 28.3 ACTC1 FLT4 KDR PDPN PROX1 VEGFA
10 lymphangiosarcoma 27.2 FLT4 HBA1 PDPN PROX1 VEGFA VEGFC
11 cystic lymphangioma 12.3
12 abdominal cystic lymphangioma 12.3
13 microcystic lymphatic malformation 12.1
14 cavernous lymphangioma 12.1
15 colonic lymphangioma 12.1
16 primary laryngeal lymphangioma 12.0
17 nuchal bleb, familial 11.7
18 cobb syndrome 11.3
19 lymphangiomatosis 11.2
20 mixed cystic lymphatic malformation 11.2
21 diffuse lymphatic malformation 11.1
22 multiple enchondromatosis, maffucci type 10.9
23 infantile myofibromatosis 10.9
24 mucinous cystadenocarcinoma of the pancreas 10.7 PDPN VEGFC
25 hemangioma, capillary infantile 10.6 FLT4 KDR
26 hemifacial spasm 10.6 FLT4 VEGFA
27 infiltrating angiolipoma 10.6 VEGFA VEGFC
28 angiokeratoma circumscriptum 10.5 KDR VEGFA
29 discoid lupus erythematosus 10.5 IFNA2 PDPN
30 radiation proctitis 10.5 KDR VEGFA
31 kuhnt-junius degeneration 10.5 KDR VEGFA
32 pulmonary vein stenosis 10.4 ACTC1 KDR
33 congenital lymphedema 10.4 FLT4 PDPN VEGFC
34 intravascular papillary endothelial hyperplasia 10.4 ACTC1 VEGFA
35 acute hemorrhagic leukoencephalitis 10.4 KDR VEGFA
36 miliaria 10.4 HBA1 PDPN
37 pyogenic granuloma 10.4 ACTC1 VEGFA
38 leukostasis 10.4 KDR VEGFA
39 senile angioma 10.4 HBA1 KDR
40 carcinoid syndrome 10.4 IFNA2 VEGFA
41 hemangioma of liver 10.4 HBA1 IFNA2
42 pediatric angiosarcoma 10.4 HBA1 VEGFA
43 mediastinitis 10.3
44 cavernous hemangioma 10.3
45 pneumatosis cystoides intestinalis 10.3 HBA1 PDPN
46 hypoglycemic coma 10.3 HBA1 VEGFA
47 glomeruloid hemangioma 10.3 HBA1 VEGFA
48 spindle cell sarcoma 10.3 ACTC1 VEGFA
49 pancreatitis 10.3
50 hemangioma-thrombocytopenia syndrome 10.3

Graphical network of the top 20 diseases related to Lymphangioma:



Diseases related to Lymphangioma

Symptoms & Phenotypes for Lymphangioma

MGI Mouse Phenotypes related to Lymphangioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 PDPN ACTC1 PROX1 FLT4 SERPINF1 VEGFA
2 homeostasis/metabolism MP:0005376 9.92 KDR PDPN ACTC1 PROX1 FLT4 VEGFA
3 immune system MP:0005387 9.86 KDR PDPN PROX1 FLT4 SERPINF1 VEGFA
4 digestive/alimentary MP:0005381 9.85 PDPN PROX1 FLT4 SERPINF1 VEGFA IFNG
5 liver/biliary system MP:0005370 9.55 KDR PROX1 FLT4 VEGFA IFNG
6 muscle MP:0005369 9.5 PDPN ACTC1 PROX1 FLT4 VEGFA IFNG
7 normal MP:0002873 9.1 KDR ACTC1 PROX1 FLT4 VEGFA IFNG

Drugs & Therapeutics for Lymphangioma

Drugs for Lymphangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Picibanil Phase 4,Phase 2,Phase 3
2
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
3
Everolimus Approved Phase 2 159351-69-6 6442177
4
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
5
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
6
Citric Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2,Phase 2 77-92-9 311
7 Phosphodiesterase 5 Inhibitors Phase 1, Phase 2,Phase 2
8 Phosphodiesterase Inhibitors Phase 1, Phase 2,Phase 2
9 Sildenafil Citrate Phase 1, Phase 2,Phase 2 171599-83-0
10 Vasodilator Agents Phase 1, Phase 2,Phase 2
11 Antineoplastic Agents, Hormonal Phase 2
12 Gastrointestinal Agents Phase 2
13 Anti-Bacterial Agents Phase 2
14 Antibiotics, Antitubercular Phase 2
15 Antifungal Agents Phase 2
16 Anti-Infective Agents Phase 2
17 Immunosuppressive Agents Phase 2
18 Citrate Nutraceutical Phase 1, Phase 2,Phase 2
19
Marimastat Approved, Investigational Phase 1 154039-60-8 119031
20
Selenium Approved, Investigational, Vet_approved Phase 1 7782-49-2
21 Antioxidants Phase 1
22 Micronutrients Phase 1
23 Protective Agents Phase 1
24 Trace Elements Phase 1
25
Pancrelipase Approved, Investigational 53608-75-6
26 Anesthetics Not Applicable
27 pancreatin

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 OK432 (Picibanil) in the Treatment of Lymphatic Malformations Active, not recruiting NCT03427619 Phase 4 OK432
2 Study of Picibanil (OK432) Sclerotherapy in Children With Macrocystic Lymphatic Malformations Completed NCT00010452 Phase 2, Phase 3 picibanil
3 A Study to Evaluate Sildenafil for the Treatment of Lymphatic Malformations Completed NCT01290484 Phase 1, Phase 2 Sildenafil
4 Sildenafil for the Treatment of Lymphatic Malformations Recruiting NCT02335242 Phase 2 Sildenafil 20 mg tablets
5 Trial of Taselisib in Overgrowth Recruiting NCT03290092 Phase 1, Phase 2 Taselisib (GDC0032);Taselisib (GDC0032)
6 Octreotide VS Placebo in Prevention of Salivary Fistulae After Post Radiation Salvage Surgery Recruiting NCT02437825 Phase 2 octreotide
7 Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies Active, not recruiting NCT00975819 Phase 2 sirolimus
8 Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic Malformations Not yet recruiting NCT03243019 Phase 2 rapamycin
9 Phase I Drug Trial for S/E of Marimastat in Disabling Malformations When no Other Options. Completed NCT00261391 Phase 1 Marimastat
10 Selenium in the Treatment of Complicated Lymphatic Malformations Terminated NCT01212965 Phase 1 Selenium
11 Imaging of Lymphatic Anomalies Completed NCT02744027 Not Applicable
12 Diagnosis of Hemangiomas and Vascular Malformations Completed NCT00577213
13 Lymphatic Anomalies Registry Recruiting NCT02399527
14 AVAST Anomalies Vasculaires Associées au Syndrome de Turner (Vascular Abnormalities Associated With Turner Syndrome) Recruiting NCT02250456
15 Development of a Specific Scale of Life'Quality for Children With Low-flow Vascular Malformations Recruiting NCT03440827 Not Applicable
16 Registry for Vascular Anomalies Associated With Coagulopathy Recruiting NCT00576888
17 Airway Vascular Lesions Active, not recruiting NCT00866827
18 Imaging Lymphatic Function in Normal Subjects and in Persons With Lymphatic Disorders Enrolling by invitation NCT00833599 NIRFLI with ICG
19 Needle-based Confocal Laser Endomicroscopy on Pancreatic Cystic Lesions Terminated NCT02494388

Search NIH Clinical Center for Lymphangioma

Cochrane evidence based reviews: lymphangioma

Genetic Tests for Lymphangioma

Genetic tests related to Lymphangioma:

# Genetic test Affiliating Genes
1 Lymphangioma 29

Anatomical Context for Lymphangioma

MalaCards organs/tissues related to Lymphangioma:

41
Pancreas, Tongue, Lymph Node, Colon, Spleen, Adrenal Gland, Endothelial

Publications for Lymphangioma

Articles related to Lymphangioma:

(show top 50) (show all 1055)
# Title Authors Year
1
Genital Warts, Lymphangioma, and Treatment with Imiquimod. ( 29803364 )
2018
2
A rare cause of small-bowel bleeding: haemorrhagic small-bowel lymphangioma diagnosed by antegrade double-balloon enteroscopy. ( 29351701 )
2018
3
Ileal Cystic Lymphangioma presenting with Acute Appendicitis. ( 29386763 )
2018
4
Lymphangioma circumscriptum of the tongue: A case with marked hemorrhagic component. ( 29315723 )
2018
5
Lymphangioma Of Tongue. ( 29504356 )
2018
6
Isolated splenic lymphangioma presenting as a huge mass causing anemia and abdominal distension in an adult patient: a case report. ( 29656712 )
2018
7
Acquired lymphangioma circumscriptum of the genitals in an individual with chronic hidradenitis suppurativa. ( 29387752 )
2018
8
Lymphangioma of the Esophagus. ( 29867174 )
2018
9
Lymphangioma circumscriptum of the vulva in a patient with Noonan syndrome. ( 29232041 )
2018
10
Endoscopic submucosal dissection of a giant esophageal lymphangioma. ( 29742767 )
2018
11
An Unusual Aspirate and Microbiopsy of a Pancreas Cyst Diagnostic for Pancreatic Lymphangioma. ( 29574030 )
2018
12
Lymphangioma on 68Ga-NOTA-Evans Blue PET/MRI. ( 29742595 )
2018
13
Lymphangioma circumscriptum treated with combination of Bleomycin sclerotherapy and Radiofrequency ablation. ( 29979907 )
2018
14
Splenic lymphangioma in an adult. ( 29543313 )
2018
15
Percutaneous full endoscopic treatment of cystic lymphangioma of cauda equina: a case report. ( 29658356 )
2018
16
Mediastinal lymphangioma in an adult. ( 29397964 )
2018
17
A young woman with steroid-responsive, IgG4-positive plasma cell-enriched cystic lymphangioma and chylous ascites. ( 29881573 )
2018
18
Sirolimus-induced regression of a large orbital lymphangioma. ( 29405800 )
2018
19
Lymphangioma Circumscriptum Post Radiotherapy for Penile Cancer Treated with COa88 Laser. ( 29782301 )
2018
20
Symptomatic lymphangioma of the adrenal gland: a case report. ( 29876049 )
2018
21
Cystic Lymphangioma: Are Triglycerides Always Measurable? ( 29686910 )
2018
22
Lymphangioma Circumscriptum in Vulva with Klippel-Trenaunay Syndrome. ( 29451158 )
2018
23
Genital Warts, Lymphangioma, and Treatment with Imiquimod. ( 29803363 )
2018
24
Percutaneous therapy of a mediastinal lymphangioma with fibrin glue: case report with clinical success after 4A years. ( 29361923 )
2018
25
A Supernumerary Nipple-Like Clinical Presentation of Lymphangioma Circumscriptum. ( 29796322 )
2018
26
Surgery of multiple lymphangioma in small bowel: a rare case report of chronic gastrointestinal bleeding. ( 29333427 )
2018
27
Retroperitoneal cystic lymphangioma in an adult: A case report. ( 29785367 )
2018
28
A case of extensive acquired progressive lymphangioma. ( 29633311 )
2018
29
Lymphangioma circumscriptum der Vulva bei einer Patientin mit Noonan-Syndrom. ( 29314699 )
2018
30
Spontaneous rupture of a retroperitoneal lymphangioma: Understanding chylous signal with chemical-shift and TrueFISP MR sequence. ( 29910170 )
2018
31
Recurring Giant Mediastinal Cystic Lymphangioma. ( 28363031 )
2017
32
Vulvar lymphangioma circumscriptum: comparison of primary and acquired forms in a cohort of 57 patients. ( 28758249 )
2017
33
An adult case of lymphangioma of the hepatoduodenal ligament mimicking a hepatic cyst. ( 28050777 )
2017
34
Acquired progressive lymphangioma: Case report with partial response to imiquimod 5% cream. ( 28940760 )
2017
35
Cystic lymphangioma in a 44-year-old woman. ( 28451011 )
2017
36
Cystic lymphangioma of spleen in adults. ( 28122799 )
2017
37
Splenic lymphangioma in an adult. ( 29114705 )
2017
38
Epididymal Cystic Lymphangioma Presenting as Scrotal Swelling in a Post Surgery Case of Carcinoma Rectum- A Case Report. ( 29207807 )
2017
39
Cystic lymphangioma of the lesser omentum in a pregnant woman: a case report and review of the literature. ( 28976139 )
2017
40
Pancreatic Lymphangioma: A Diagnostic and Treatment Dilemma. ( 28738930 )
2017
41
A prospective study of the role of intralesional bleomycin in orbital lymphangioma. ( 28300684 )
2017
42
A Large Hemispherical Colon Lymphangioma. ( 28050035 )
2017
43
Transient Reactive Eruptive Lymphangiectasia Following Partial Vulvectomy for Chronic Acquired Lymphangioma. ( 28859749 )
2017
44
Mixed Lymphangioma and Cavernous Hemangioma Within the Ulnar Nerve: A Case Report. ( 28391718 )
2017
45
Small bowel volvulus in an adult with mesenteric lymphangioma and ascariasis. ( 28266164 )
2017
46
Natural Course of Fetal Axillary Lymphangioma Based on Prenatal Ultrasound Studies. ( 29119576 )
2017
47
Thoracoscopic resection of a huge mediastinal cystic lymphangioma. ( 29268428 )
2017
48
Imaging findings of axillary cystic lymphangioma in adult. ( 28735807 )
2017
49
Incidental finding of (131)I uptake in mesenteric cystic lymphangioma on post-therapy (131)I SPECT/CT imaging. ( 28215398 )
2017
50
Cystic Lymphangioma of the Colon: Endoscopic Removal beyond the Frontiers of Size. ( 28512390 )
2017

Variations for Lymphangioma

Expression for Lymphangioma

Search GEO for disease gene expression data for Lymphangioma.

Pathways for Lymphangioma

Pathways related to Lymphangioma according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.19 FLT4 IFNA2 IFNG KDR VEGFA VEGFC
2
Show member pathways
12.67 FLT4 KDR VEGFA VEGFC
3
Show member pathways
12.63 FLT4 IFNA2 KDR VEGFA VEGFC
4 12.54 FLT4 KDR VEGFA VEGFC
5
Show member pathways
12.48 FLT4 KDR VEGFA VEGFC
6 12.44 FLT4 IFNA2 IFNG VEGFA VEGFC
7
Show member pathways
12.11 FLT4 KDR VEGFA VEGFC
8
Show member pathways
12.05 FLT4 KDR VEGFA VEGFC
9
Show member pathways
12.02 KDR VEGFA VEGFC
10 11.89 FLT4 KDR VEGFC
11 11.84 IFNG KDR VEGFA
12 11.81 KDR PROX1 VEGFA
13
Show member pathways
11.81 FLT4 IFNG KDR VEGFC
14
Show member pathways
11.42 FLT4 KDR VEGFA VEGFC
15 11.3 FLT4 KDR PDPN PROX1 VEGFC
16 11.19 IFNA2 IFNG
17 11.16 HBA1 IFNG
18 11.14 KDR VEGFA
19 11.06 FLT4 KDR VEGFA
20 10.96 KDR VEGFA
21 10.94 FLT4 VEGFC
22 10.86 IFNG VEGFA
23 10.41 VEGFA VEGFC
24
Show member pathways
10.13 FLT4 KDR VEGFA VEGFC

GO Terms for Lymphangioma

Cellular components related to Lymphangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 ACTC1 HBA1 IFNA2 IFNG SERPINF1 VEGFA
2 extracellular region GO:0005576 9.23 FLT4 HBA1 IFNA2 IFNG KDR SERPINF1

Biological processes related to Lymphangioma according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.95 FLT4 KDR PDPN PROX1 SERPINF1 VEGFA
2 regulation of signaling receptor activity GO:0010469 9.94 IFNA2 IFNG VEGFA VEGFC
3 negative regulation of apoptotic process GO:0043066 9.93 ACTC1 FLT4 KDR PDPN VEGFA
4 positive regulation of cell migration GO:0030335 9.85 KDR PDPN VEGFA
5 angiogenesis GO:0001525 9.85 FLT4 KDR VEGFA VEGFC
6 positive regulation of cell proliferation GO:0008284 9.85 FLT4 IFNG KDR PROX1 VEGFA VEGFC
7 regulation of cell shape GO:0008360 9.83 KDR PDPN VEGFA
8 positive regulation of angiogenesis GO:0045766 9.82 KDR VEGFA VEGFC
9 kidney development GO:0001822 9.8 PROX1 SERPINF1 VEGFA
10 lung development GO:0030324 9.77 PDPN PROX1 VEGFA
11 positive regulation of protein phosphorylation GO:0001934 9.76 FLT4 IFNG KDR VEGFA
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.73 IFNA2 IFNG VEGFA
13 negative regulation of gene expression GO:0010629 9.72 IFNA2 IFNG KDR SERPINF1 VEGFA
14 vasculogenesis GO:0001570 9.7 FLT4 KDR VEGFA
15 positive chemotaxis GO:0050918 9.68 VEGFA VEGFC
16 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.67 KDR VEGFA
17 positive regulation of focal adhesion assembly GO:0051894 9.67 KDR VEGFA
18 positive regulation of protein complex assembly GO:0031334 9.66 IFNG VEGFA
19 positive regulation of protein autophosphorylation GO:0031954 9.66 VEGFA VEGFC
20 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.65 IFNA2 IFNG
21 positive regulation of neuroblast proliferation GO:0002052 9.65 VEGFA VEGFC
22 positive regulation of blood vessel endothelial cell migration GO:0043536 9.65 KDR VEGFA VEGFC
23 cell migration involved in sprouting angiogenesis GO:0002042 9.63 KDR VEGFA
24 induction of positive chemotaxis GO:0050930 9.63 VEGFA VEGFC
25 positive regulation of positive chemotaxis GO:0050927 9.62 KDR VEGFA
26 lymph vessel development GO:0001945 9.61 FLT4 PROX1
27 vascular endothelial growth factor signaling pathway GO:0038084 9.61 FLT4 KDR
28 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.61 FLT4 KDR VEGFA
29 positive regulation of cellular component movement GO:0051272 9.59 PDPN VEGFA
30 skeletal muscle thin filament assembly GO:0030240 9.58 ACTC1 PROX1
31 positive regulation of protein kinase C signaling GO:0090037 9.58 FLT4 VEGFA
32 positive regulation of mast cell chemotaxis GO:0060754 9.57 VEGFA VEGFC
33 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.56 FLT4 KDR VEGFA VEGFC
34 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.51 KDR VEGFA
35 actin-mediated cell contraction GO:0070252 9.49 ACTC1 PDPN
36 lymphangiogenesis GO:0001946 9.33 FLT4 PDPN PROX1
37 positive regulation of endothelial cell migration GO:0010595 9.26 FLT4 KDR PROX1 VEGFA
38 positive regulation of endothelial cell proliferation GO:0001938 9.02 FLT4 KDR PROX1 VEGFA VEGFC

Molecular functions related to Lymphangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 9.16 VEGFA VEGFC
2 cytokine activity GO:0005125 9.13 IFNA2 IFNG VEGFA
3 vascular endothelial growth factor-activated receptor activity GO:0005021 8.62 FLT4 KDR

Sources for Lymphangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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