Lymphangioma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LYM022 MIFTS: 49	Lymphangioma Categories: Cancer diseases, Immune diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Lymphangioma

MalaCards integrated aliases for Lymphangioma:

Name: Lymphangioma ¹² ³⁷ ²⁹ ⁵⁵ ⁴⁴ ¹⁵ ⁷³

Congenital Lymphangioma ¹²

Benign Lymphangioma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Neoplasms

Benign neoplasms

Haemangioma and lymphangioma, any site

Lymphangioma, any site

External Ids:

Disease Ontology ¹² DOID:1475

ICD10 ³³ D18.1

ICD9CM ³⁵ 228.1

MeSH ⁴⁴ D008202

NCIt ⁵⁰ C8965

SNOMED-CT ⁶⁸ 69044001 93168006

KEGG ³⁷ H01471

UMLS ⁷³ C0024221

Sources

Summaries for Lymphangioma

MalaCards based summary : Lymphangioma, also known as congenital lymphangioma, is related to orbital lymphangioma and lymphatic malformations. An important gene associated with Lymphangioma is FLT4 (Fms Related Tyrosine Kinase 4), and among its related pathways/superpathways are Nanog in Mammalian ESC Pluripotency and Focal Adhesion. The drugs Picibanil and Octreotide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, tongue and lymph node, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : ⁷⁶ Lymphangiomas are malformations of the lymphatic system characterized by lesions that are thin-walled... more...

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Related Diseases for Lymphangioma

Diseases related to Lymphangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 248)

#	Related Disease	Score	Top Affiliating Genes
1	orbital lymphangioma	33.6	FLT4 PDPN
2	lymphatic malformations	33.4	FLT4 PROX1
3	capillary lymphangioma	33.4	HBA1 PROX1
4	infantile myofibromatosis	31.6	ACTC1 VIM
5	kaposiform hemangioendothelioma	30.5	FLT4 KDR PROX1
6	malignant hemangioma	30.3	FLT4 KDR
7	lymphangiectasis	30.3	ACTC1 VIM
8	kaposi sarcoma	30.3	IFNA2 KDR VEGFA
9	hemangioendothelioma	30.3	FLT4 KDR
10	hemangioma	30.3	ACTC1 FLT4 KDR PDPN PROX1 VEGFA
11	epithelioid hemangioendothelioma	30.1	KDR VEGFA
12	gorham's disease	30.0	FLT4 IFNA2 VEGFC
13	glomus tumor	30.0	ACTC1 VIM
14	hydrocele	29.8	FLT4 VEGFA
15	congenital lymphedema	29.8	FLT4 PDPN VEGFC
16	spindle cell sarcoma	29.7	ACTC1 VIM
17	gastrointestinal stromal tumor	29.5	ACTC1 VEGFA VIM
18	alveoli adenoma	29.4	FLT4 HBA1 PROX1
19	lymphangiosarcoma	29.2	FLT4 HBA1 PDPN PROX1 VEGFA VEGFC
20	cystic lymphangioma	12.5
21	abdominal cystic lymphangioma	12.5
22	microcystic lymphatic malformation	12.2
23	cavernous lymphangioma	12.2
24	colonic lymphangioma	12.2
25	primary laryngeal lymphangioma	12.1
26	nuchal bleb, familial	12.0
27	diffuse lymphatic malformation	11.6
28	cobb syndrome	11.5
29	lymphangiomatosis	11.4
30	mixed cystic lymphatic malformation	11.3
31	multiple enchondromatosis, maffucci type	11.0
32	cavernous hemangioma	10.5
33	hemangioma-thrombocytopenia syndrome	10.4
34	retiform hemangioendothelioma	10.4
35	sarcoma	10.3
36	mucinous cystadenocarcinoma of the pancreas	10.2	PDPN VEGFC
37	malignant epithelioid hemangioendothelioma	10.2	FLT4 KDR
38	hereditary lymphedema	10.2	FLT4 VEGFC
39	hemangioma, capillary infantile	10.2	FLT4 KDR
40	hemifacial spasm	10.2	FLT4 VEGFA
41	intussusception	10.2
42	infiltrating angiolipoma	10.2	VEGFA VEGFC
43	angiokeratoma circumscriptum	10.2	KDR VEGFA
44	discoid lupus erythematosus	10.2	IFNA2 PDPN
45	radiation proctitis	10.2	KDR VEGFA
46	klippel-trenaunay-weber syndrome	10.2
47	pulmonary vein stenosis	10.2	ACTC1 KDR
48	miliaria	10.2	HBA1 PDPN
49	leukostasis	10.1	KDR VEGFA
50	pyogenic granuloma	10.1	ACTC1 VEGFA

Graphical network of the top 20 diseases related to Lymphangioma:

Sources

Symptoms & Phenotypes for Lymphangioma

MGI Mouse Phenotypes related to Lymphangioma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.91	ACTC1 FLT4 KDR PDPN PROX1 SERPINF1
2	homeostasis/metabolism	MP:0005376	9.76	ACTC1 FLT4 KDR PDPN PROX1 VEGFA
3	immune system	MP:0005387	9.56	FLT4 KDR PDPN PROX1 SERPINF1 VEGFA
4	muscle	MP:0005369	9.17	ACTC1 FLT4 KDR PDPN PROX1 VEGFA

Sources

Drugs & Therapeutics for Lymphangioma

Drugs for Lymphangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Picibanil

Phase 4,Phase 2,Phase 3

Octreotide

Approved, Investigational

Phase 2

83150-76-9

383414 6400441

Synonyms:

(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide

10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa

10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide

10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide

79517-01-4 (acetate salt)

83150-76-9

AC1L1GVU

AC1L8LCD

AC1L9M4X

C07306

C5H12O2.C4H10

CHEBI:427278

CHEBI:611465

CHEMBL1680

CID383414

CID448601

CID54374

Compound 201 995

Compound 201995

Compound 201-995

D00442

D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide

D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide

D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide

DRG-0115

HMS2090C09

HS-2020

L000453

L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L- threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide, (R-(R*

Longastatin

LS-177735

LS-187135

NCGC00181796-01

nchembio.184-comp3

NCI60_025753

Octreotida

Octreotida [Spanish]

Octreotide

Octreotide (USAN/INN)

Octreotide [USAN:INN:BAN]

Octreotide acetate

Octreotide acetate salt

Octreotide Acetate Salt

Octreotide-LAR

Octreotidum

Octreotidum [Latin]

Octrotide

SAN 201-995

Sandostatin

Sandostatine

Sandoz 201 995

Sandoz 201995

Sandoz 201-995

SM 201-995

SMS 201-995

SMS-201-995

UNII-RWM8CCW8GP

zacycloicosane-4-carboxamide acetate

Everolimus

Approved

Phase 2

159351-69-6

6442177

Synonyms:

(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.0(sup 4,9))hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone

(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.04,9)hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone

(1R,9S,12S,15R,16E,23S,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.0(sup 4,9))hexatriacont

(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34as)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethy

(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone

(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone

001, RAD

07741_FLUKA

159351-69-6

40-O-(2-hydroxyethyl)-rapamycin

40-O-(2-Hydroxyethyl)-rapamycin

42-O-(2-Hydroxyethyl)rapamycin

Afinitor

Certican

CERTICAN(R)

CHEMBL1201755

D02714

DB01590

everolimus

Everolimus

Everolimus (JAN/USAN/INN)

Everolimus [USAN]

LS-143292

MolPort-003-847-342

MolPort-003-925-588

NCGC00167512-01

NVP-RAD-001

RAD 001

RAD, SDZ

RAD001

RAD-001

RAD001, SDZ-RAD, Certican, Zortress, Afinitor, Everolimus

RAD-001C

S1120_Selleck

SDZ RAD

SDZ-RAD

UNII-9HW64Q8G6G

Zortress

Sirolimus

Approved, Investigational

Phase 2

53123-88-9

46835353 6436030 5284616

Synonyms:

(-)-rapamycin

(-)-Rapamycin

1fkb

1pbk

23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine

23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine

23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29

3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone

53123-88-9

A422989, NSC226080

AC1L1JH9

AC1L7MJ9

AC1L9ZMV

AC-722

Ambotz53123-88-9

Antibiotic AY 22989

AY 22989

AY22989

AY-22989

BIDD:PXR0165

Bio1_000293

Bio1_000782

Bio1_001271

Bio2_000375

Bio2_000855

BiomolKI2_000084

C07909

C51H79NO13

CBiol_002007

CCRIS 9024

CHEBI:100923

CHEBI:9168

CHEMBL413

CID10213190

CID10795871

CID11949238

CID11959112

CID313006

CID478951

CID5040

CID5284616

CID5358081

CID5374464

CID5460439

CID5497196

CID5924240

CID6436030

CID6610270

CID6610346

CID6711160

CID6713081

CID9833581

CID9854379

CID9854380

CID9962926

CID9962928

D00753

DB00877

DE-109

DivK1c_006936

FT-0082351

heptadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy

HMS2089A21

HSDB 7284

KBio1_001880

KBio2_000410

KBio2_002978

KBio2_005546

KBio3_000779

KBio3_000780

KBioGR_000410

KBioSS_000410

LCP-Siro

LMPK06000003

LS-143290

MLS000028373

MolMap_000043

MolPort-003-959-433

MS-R001

NCGC00021305-05

nchembio.100-comp4

nchembio.2007.42-comp2

nchembio.79-comp1

nchembio762-comp1

nchembio883-comp3

NCI60_001851

NCIMech_000355

NSC 226080

NSC226080

Perceiva

QTL1_000069

R0395_SIAL

R0395_SIGMA

RAP

RAPA

Rapammune

Rapamune

Rapamune (TN)

rapamycin

Rapamycin

Rapamycin (TN)

Rapamycin C-7, analog 4

Rapamycin from Streptomyces hygroscopicus

Rapamycin Immunosuppressant Drug

RPM

S1039_Selleck

SIIA 9268A

SILA 9268A

SILA9268A

sirolimus

Sirolimus

sirolimús

Sirolimus (RAPAMUNE)

Sirolimus (USAN/INN)

Sirolimus [USAN:BAN:INN]

Sirolimus, Rapamune,Rapamycin

sirolimusum

SMP1_000255

SMR000058564

SpecPlus_000840

UNII-W36ZG6FT64

UNM-0000358684

Wy 090217

WY-090217

Miconazole

Approved, Investigational, Vet_approved

Phase 2

22916-47-8

4189

Synonyms:

(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole

1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole

1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole

1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole

1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole

1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole

1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole

1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole

1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole

1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole

22832-87-7 (NITRATE)

22916-47-8

75319-47-0

AB00053500

AC1L1HM1

Aflorix(nitrate)

AKOS001574474

Albistat(nitrate)

Andergin(nitrate)

BPBio1_000279

BRD-A82396632-001-03-0

BRD-A82396632-008-02-7

Brentan

BRN 0965511

BSPBio_000253

BSPBio_002033

CCRIS 7924

CHEBI:6923

CHEMBL91

CID4189

Conofite(nitrate)

CPD-4501

D00416

Dactarin

Daktarin iv

Daktarin IV

DB01110

DivK1c_000156

EINECS 245-324-5

Epi-Monistat(nitrate)

Esteve brand OF miconazole

Femizol-M

Florid(nitrate)

Gyno-Daktar(nitrate)

HMS1568M15

HMS2090B21

I14-14342

IDI1_000156

imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)

Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)

Janssen cilag brand OF miconazole

Janssen-cilag brand OF miconazole

Johnston and johnston brand OF miconazole nitrate

KBio1_000156

KBio2_001445

KBio2_004013

KBio2_006581

KBio3_001533

KBioGR_000581

KBioSS_001445

Lotrimin AF(nitrate)

LS-78378

MCZ

Micantin (nitrate)

Miconasil nitrate

Miconasil Nitrate

Miconazol

Miconazol [INN-Spanish]

miconazole

Miconazole

Miconazole (JP15/USP/INN)

Miconazole [USAN:BAN:INN:JAN]

Miconazole 3

Miconazole 3 Combination Pack

Miconazole 7 Combination Pack

Miconazole esteve brand

Miconazole janssen-cilag brand

Miconazole nitrate

Miconazole nitrate salt

Miconazole-7

Miconazolo

Miconazolo [DCIT]

Miconazolum

Miconazolum [INN-Latin]

Micozole

Minostate

MJR 1762

MLS002222203

MolPort-002-557-553

Monazole 7

Monista (nitrate)

Monistat

Monistat (TN)

Monistat 1 Combination Pack

Monistat 3 Dual-Pak

Monistat 3 Vaginal Ovules

Monistat 5 Tampon

Monistat 7 Dual-Pak

Monistat 7 Vaginal Suppositories

Monistat Dual- PAK

Monistat IV

Monistat iv (tn)

Monistat iv (TN)

Monistat-Derm

NCI60_001353

NCI60_001380

NINDS_000156

Nitrate, miconasil

Nitrate, miconazole

Novo-Miconazole Vaginal Ovules

NSC 170986

NSC169434

NSC170986

Oprea1_091955

Prestwick_335

Prestwick0_000067

Prestwick1_000067

Prestwick2_000067

Prestwick3_000067

R 18134

R-14,889

SMR001307249

SPBio_000976

SPBio_002174

Spectrum_000965

Spectrum2_001048

Spectrum3_000507

Spectrum4_000061

Spectrum5_001297

STK834405

STOCK1S-93556

UNII-7NNO0D7S5M

Vusion

Zimycan

Citric Acid

Approved, Nutraceutical, Vet_approved

Phase 1, Phase 2,Phase 2

77-92-9

311

Synonyms:

2-hydroxy-1,2,3-propanetricarboxyic acid

2-Hydroxy-1,2,3-propanetricarboxylate

2-Hydroxy-1,2,3-propanetricarboxylic acid

2-Hydroxytricarballylate

2-Hydroxytricarballylic acid

3-Carboxy-3-hydroxypentane-1,5-dioate

3-carboxy-3-hydroxypentane-1,5-dioic acid

3-Carboxy-3-hydroxypentane-1,5-dioic acid

Acid monohydrate, citric

Acidum citricum

Aciletten

Anhydrous citrate

Anhydrous citric acid

beta-Hydroxytricarballylate

beta-Hydroxytricarballylic acid

Chemfill

Citraclean

Citrate

Citretten

Citric acid monoglyceride

Citric acid monohydrate

Citric acid, anhydrous

Citric Acid, Anhydrous

Citric acid,anhydrous

Citro

Citronensaeure

Citronensäure

e 330

e330

H3Cit

Hydrocerol a

Kyselina citronova

Monohydrate, citric acid

Suby g

Uralyt u

uro-Trainer

Antineoplastic Agents, Hormonal

Phase 2

Gastrointestinal Agents

Phase 2

Phosphodiesterase 5 Inhibitors

Phase 1, Phase 2,Phase 2

Phosphodiesterase Inhibitors

Phase 1, Phase 2,Phase 2

Citrate

Phase 1, Phase 2,Phase 2

Sildenafil Citrate

Phase 1, Phase 2,Phase 2

171599-83-0

Vasodilator Agents

Phase 1, Phase 2,Phase 2

Anti-Bacterial Agents

Phase 2

Antibiotics, Antitubercular

Phase 2

Immunosuppressive Agents

Phase 2

Anti-Infective Agents

Phase 2

Immunologic Factors

Phase 2

Antifungal Agents

Phase 2

Selenium

Approved, Investigational, Vet_approved

Phase 1

7782-49-2

Synonyms:

Se(2+)

Se2+

Selanediide

Selen

Selenide

Selenide(2-)

Selenio

Sélénium

Selenium dication

Selenium elemental

Selenium ion (se2+)

Selenium metallicum

Selenium, elemental

Marimastat

Investigational

Phase 1

154039-60-8

119031

Synonyms:

(2R,3S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N',3-dihydroxy-2-(2-methylpropyl)butanediamide

(2S,3R)-3-(((1S)-2,2-Dimethyl-1-(methylcarbamoxy)propyl)carboyl)-2-hydroxy-5-methylhexanohydroxamic acid

(2S,3R)-3-(((1S)-2,2-Dimethyl-1-(methylcarbamoyl)propyl)carbamoyl)-2-hydroxy-5-methylhexanohydroxamic acid

(2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N(1),2-dihydroxy-3-(2-methylpropyl)butanediamide

15039-60-8

154039-60-8

AC1L3O2N

BB 2516

BB-2516

C100342

C15H29N3O5

CHEBI:50662

CHEMBL279785

CID119031

D03795

DB00786

LS-45634

Marimastat

Marimastat (USAN/INN)

Marimastat [USAN]

UNII-D5EQV23TDS

Antioxidants

Phase 1

Trace Elements

Phase 1

Protective Agents

Phase 1

Micronutrients

Phase 1

Pancrelipase

Approved, Investigational

53608-75-6

Anesthetics

Not Applicable

pancreatin

Interventional clinical trials:

(show all 19)

#	Name	Status	NCT ID	Phase	Drugs
1	OK432 (Picibanil) in the Treatment of Lymphatic Malformations	Completed	NCT03427619	Phase 4	OK432
2	Study of Picibanil (OK432) Sclerotherapy in Children With Macrocystic Lymphatic Malformations	Completed	NCT00010452	Phase 2, Phase 3	picibanil
3	Octreotide VS Placebo in Prevention of Salivary Fistulae After Post Radiation Salvage Surgery	Unknown status	NCT02437825	Phase 2	octreotide
4	A Study to Evaluate Sildenafil for the Treatment of Lymphatic Malformations	Completed	NCT01290484	Phase 1, Phase 2	Sildenafil
5	Sildenafil for the Treatment of Lymphatic Malformations	Recruiting	NCT02335242	Phase 2	Sildenafil 20 mg tablets
6	Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic Malformations	Recruiting	NCT03243019	Phase 2	rapamycin
7	Trial of Taselisib in Overgrowth	Recruiting	NCT03290092	Phase 1, Phase 2	Taselisib (GDC0032);Taselisib (GDC0032)
8	Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies	Active, not recruiting	NCT00975819	Phase 2	sirolimus
9	Phase I Drug Trial for S/E of Marimastat in Disabling Malformations When no Other Options.	Completed	NCT00261391	Phase 1	Marimastat
10	Selenium in the Treatment of Complicated Lymphatic Malformations	Terminated	NCT01212965	Phase 1	Selenium
11	Airway Vascular Lesions	Completed	NCT00866827
12	Imaging of Lymphatic Anomalies	Completed	NCT02744027	Not Applicable
13	Diagnosis of Hemangiomas and Vascular Malformations	Completed	NCT00577213
14	Lymphatic Anomalies Registry	Recruiting	NCT02399527
15	AVAST Anomalies Vasculaires Associées au Syndrome de Turner (Vascular Abnormalities Associated With Turner Syndrome)	Recruiting	NCT02250456
16	Development of a Specific Scale of Life'Quality for Children With Low-flow Vascular Malformations	Recruiting	NCT03440827	Not Applicable
17	Registry for Vascular Anomalies Associated With Coagulopathy	Recruiting	NCT00576888
18	Imaging Lymphatic Function in Normal Subjects and in Persons With Lymphatic Disorders	Enrolling by invitation	NCT00833599		NIRFLI with ICG
19	Needle-based Confocal Laser Endomicroscopy on Pancreatic Cystic Lesions	Terminated	NCT02494388

Search NIH Clinical Center for Lymphangioma

Cochrane evidence based reviews: lymphangioma

Sources

Genetic Tests for Lymphangioma

Genetic tests related to Lymphangioma:

#	Genetic test	Affiliating Genes
1	Lymphangioma ²⁹

Sources

Anatomical Context for Lymphangioma

MalaCards organs/tissues related to Lymphangioma:

⁴¹

Pancreas, Tongue, Lymph Node, Colon, Spleen, Breast, Ovary

Sources

Publications for Lymphangioma

Articles related to Lymphangioma:

(show top 50) (show all 1295)

#	Title	Authors	Year
1	Giant cystic lymphangioma of adrenal gland: A case report and review of the literature. ( 30306048 )	Bibi M...Nouira Y	2019
2	Genital Warts, Lymphangioma, and Treatment with Imiquimod. ( 29803364 )	Padilla-EspaA+a L....MillA!n-Cayetano J.F.	2018
3	A rare cause of small-bowel bleeding: haemorrhagic small-bowel lymphangioma diagnosed by antegrade double-balloon enteroscopy. ( 29351701 )	Gaeta L....Despott E.J.	2018
4	Ileal Cystic Lymphangioma presenting with Acute Appendicitis. ( 29386763 )	Lui S.A....Mali V.P.	2018
5	Lymphangioma circumscriptum of the tongue: A case with marked hemorrhagic component. ( 29315723 )	Alrashdan M.S....Alorjani M.	2018
6	Lymphangioma Of Tongue. ( 29504356 )	Bajpai M....Kumar M.	2018
7	Isolated splenic lymphangioma presenting as a huge mass causing anemia and abdominal distension in an adult patient: a case report. ( 29656712 )	Efared B....Chbani L.	2018
8	Acquired lymphangioma circumscriptum of the genitals in an individual with chronic hidradenitis suppurativa. ( 29387752 )	Piernick D.M....Daveluy S.	2018
9	Lymphangioma of the Esophagus. ( 29867174 )	Min M....Liu Y.	2018
10	Lymphangioma circumscriptum of the vulva in a patient with Noonan syndrome. ( 29232041 )	Schirra A....Streit E.	2018
11	Endoscopic submucosal dissection of a giant esophageal lymphangioma. ( 29742767 )	Hu L....Wu H.	2018
12	An Unusual Aspirate and Microbiopsy of a Pancreas Cyst Diagnostic for Pancreatic Lymphangioma. ( 29574030 )	Trindade A.J....Rishi A.	2018
13	Lymphangioma on 68Ga-NOTA-Evans Blue PET/MRI. ( 29742595 )	Hou G....Cheng W.	2018
14	Lymphangioma circumscriptum treated with combination of Bleomycin sclerotherapy and Radiofrequency ablation. ( 29979907 )	Khurana A....Malhotra P.	2018
15	Splenic lymphangioma in an adult. ( 29543313 )		2018
16	Percutaneous full endoscopic treatment of cystic lymphangioma of cauda equina: a case report. ( 29658356 )		2018
17	Mediastinal lymphangioma in an adult. ( 29397964 )		2018
18	A young woman with steroid-responsive, IgG4-positive plasma cell-enriched cystic lymphangioma and chylous ascites. ( 29881573 )		2018
19	Sirolimus-induced regression of a large orbital lymphangioma. ( 29405800 )		2018
20	Lymphangioma Circumscriptum Post Radiotherapy for Penile Cancer Treated with COa88 Laser. ( 29782301 )		2018
21	Symptomatic lymphangioma of the adrenal gland: a case report. ( 29876049 )		2018
22	Cystic Lymphangioma: Are Triglycerides Always Measurable? ( 29686910 )		2018
23	Lymphangioma Circumscriptum in Vulva with Klippel-Trenaunay Syndrome. ( 29451158 )		2018
24	Genital Warts, Lymphangioma, and Treatment with Imiquimod. ( 29803363 )		2018
25	Percutaneous therapy of a mediastinal lymphangioma with fibrin glue: case report with clinical success after 4A years. ( 29361923 )		2018
26	A Supernumerary Nipple-Like Clinical Presentation of Lymphangioma Circumscriptum. ( 29796322 )		2018
27	Surgery of multiple lymphangioma in small bowel: a rare case report of chronic gastrointestinal bleeding. ( 29333427 )		2018
28	Retroperitoneal cystic lymphangioma in an adult: A case report. ( 29785367 )		2018
29	A case of extensive acquired progressive lymphangioma. ( 29633311 )		2018
30	Lymphangioma circumscriptum der Vulva bei einer Patientin mit Noonan-Syndrom. ( 29314699 )		2018
31	Spontaneous rupture of a retroperitoneal lymphangioma: Understanding chylous signal with chemical-shift and TrueFISP MR sequence. ( 29910170 )		2018
32	Single-port laparoscopic-assisted resection for a large abdominal cystic lymphangioma: a case report. ( 30105531 )	Kogo H...Uchida E	2018
33	Intra-Abdominal Cystic Lymphangioma. ( 30318372 )	Chew BJW...Khare MM	2018
34	Mediastinal Lymphangioma Complicated by Chylopericardium, Tamponade, and Cardiac Arrest Treated with an Endolymphatic Stent Graft. ( 30266225 )	Malhotra G...Srinivasa RN	2018
35	A Rare, Giant, Cystic, and Cavernous Lymphangioma Originated from the Stomach in a Young Woman. ( 30039446 )	Zhuang K...Huang S	2018
36	Rare Case of Pancreatic Cystic Lymphangioma. ( 29151529 )	Fujii M...Shiode J	2018
37	Cystic lymphangioma of pancreas: A rare case report and review of the literature. ( 29995757 )	Chen D...Wu J	2018
38	Adult Cystic Lymphangioma of the Parotid Gland: An Unwonted Presentation. ( 30034966 )	Chinnakkulam Kandhasamy S...Gunasekaran G	2018
39	Congenital superior caval vein aneurysm in a newborn with cystic lymphangioma: a rare case report. ( 30043721 )	Attene J...Versacci P	2018
40	Cystic lymphangioma of nasopharynx in a 54-year-old man - case report. A new histogenetic hypothesis. ( 30173266 )	Vr?nceanu D...Georgescu MG	2018
41	Cystic lymphangioma of the pancreas: a hard diagnostic challenge between pancreatic cystic lesions-review of recent literature. ( 30505770 )	Viscosi F...Cucinotta E	2018
42	Coincidental Lymphangioma and Hemangioma in a Single Lymph Node. ( 30376741 )	Collins K...DiGiuseppe JA	2018
43	Jejunal lymphangioma causing intussusception in an adult: An unusual case with review of the literature. ( 30210794 )	Samuelson H...Guralnick A	2018
44	Palmoplantar lymphangioma-like Kaposi sarcoma. ( 30506813 )	V?zquez-Osorio I...Rodr?guez-D?az E	2018
45	Cystic mesenteric lymphangioma: a case report. ( 28419699 )	Durgakeri P...Penington B	2018
46	Sonographic findings in two cases of lymphangioma of the mesocolon in adults. ( 28440897 )	Naganuma H...Miyauchi T	2018
47	Axillary lymphangioma in an asymptomatic adult female. ( 28877380 )	Chotai N...Ho B	2018
48	Vulvar Lymphangioma Circumscriptum Treated With Fractional Ablative Erbium: Yttrium Aluminium Garnet Laser. ( 29077628 )	Makdisi J...Zachary CB	2018
49	A case of lymphangioma-like mesenteric cysts diagnosed as adenocarcinoma of possible pancreatic origin on EUS-FNA. ( 29113789 )	Delvincourt M...Carroll NR	2018
50	Lymphangioma cavernous of the small bowel mesentery, an infrequent cause of acute abdomen in adult. ( 29479419 )	Rojas CL...Molina GA	2018

Sources

Genes for Lymphangioma

Genes related to Lymphangioma (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	FLT4	Fms Related Tyrosine Kinase 4	Protein Coding	31.81	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	19151999 11742043 17584927 (more) 12060670 10697276 11585321 10590384
2	VEGFC	Vascular Endothelial Growth Factor C	Protein Coding	27.42	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	19151999 11742043
3	PROX1	Prospero Homeobox 1	Protein Coding	24.83	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	12060670 17584927
4	PDPN	Podoplanin	Protein Coding	22.48	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	14559986 10931742 16670463 (more) 11585321 17584927
5	KDR	Kinase Insert Domain Receptor	Protein Coding	20.87	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	IFNA2	Interferon Alpha 2	Protein Coding	20	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	19.76	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	ACTC1	Actin, Alpha, Cardiac Muscle 1	Protein Coding	19.19	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	10922105
9	HBA1	Hemoglobin Subunit Alpha 1	Protein Coding	16.79	DISEASES inferred ¹⁵
10	VIM	Vimentin	Protein Coding	16.59	GeneCards inferred via : Publications (show sections)
11	SERPINF1	Serpin Family F Member 1	Protein Coding	16.59	GeneCards inferred via : Publications (show sections)

Sources

Variations for Lymphangioma

Sources

Expression for Lymphangioma

Search GEO for disease gene expression data for Lymphangioma.

Sources

Pathways for Lymphangioma

Pathways related to Lymphangioma according to GeneCards Suite gene sharing:

(show all 23)

#	Super pathways	Score	Top Affiliating Genes
1	Nanog in Mammalian ESC Pluripotency ⁶⁴ Show member pathways 14-3-3 Induced Intracellular Signaling ⁶⁴ eNOS Signaling ⁶⁴ GSK3 Signaling ⁶⁴	13.04	FLT4 KDR VEGFA VEGFC VIM
2	Focal Adhesion ¹ ³⁷ Show member pathways HGF Pathway ⁶⁴ Integrin-mediated Cell Adhesion ¹	12.67	FLT4 KDR VEGFA VEGFC
3	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.67	FLT4 IFNA2 KDR VEGFA VEGFC
4	Pathways in cancer ³⁷	12.61	FLT4 IFNA2 VEGFA VEGFC
5	MAPK signaling pathway ³⁷ ¹	12.52	FLT4 KDR VEGFA VEGFC
6	Ras signaling pathway ³⁷ Show member pathways Rap1 signaling pathway ³⁷	12.47	FLT4 KDR VEGFA VEGFC
7	TRAF Pathway ⁶⁴ Show member pathways 14-3-3 Induced Apoptosis ⁶⁴ TNF Superfamily Pathway ⁶⁴ Toll-Like Receptors Pathway ⁶⁴	12.34	FLT4 KDR VEGFA VEGFC
8	VEGF Pathway (Qiagen) ²² Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶⁴ Neurophilin interactions with VEGF and VEGFR ⁶⁶ VEGF Family Ligands and Receptor Interactions ⁶⁴ VEGF Pathway ⁶⁴	12.13	FLT4 KDR VEGFA VEGFC
9	RhoGDI Pathway ⁶⁴ Show member pathways Fc-GammaR-Mediated Phagocytosis in Macrophages ⁶⁴	12.09	FLT4 KDR VEGFA VEGFC
10	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶⁴ Interferon alpha/beta signaling ⁶⁶ Regulation of IFNA signaling ⁶⁶	12.01	FLT4 IFNA2 KDR VEGFC
11	VEGF Signaling Pathway ⁶¹ ⁶⁷ Show member pathways Nanoparticle-mediated activation of receptor signaling ¹ TGF-beta Signaling ⁶⁷	12	KDR VEGFA VEGFC
12	Tyrosine Kinases / Adaptors ⁴	11.88	FLT4 KDR VEGFC
13	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.68	KDR PROX1 VEGFA VIM
14	Signaling events mediated by VEGFR1 and VEGFR2 ¹ Show member pathways VEGFR1 specific signals ¹	11.42	FLT4 KDR VEGFA VEGFC
15	Angiogenesis (CST) ⁴	11.3	FLT4 KDR PDPN PROX1 VEGFC
16	Vemurafenib Pathway, Pharmacodynamics ⁶¹	11.17	FLT4 KDR VEGFA
17	HIF-2-alpha transcription factor network ¹	11.14	KDR VEGFA
18	Angiogenesis (WikiPathways) ¹	10.96	KDR VEGFA
19	VEGFR3 signaling in lymphatic endothelium ¹	10.92	FLT4 VEGFC
20	G-protein signaling_Rap2B regulation pathway ²²	10.8	FLT4 KDR VEGFC VIM
21	Cytoskeleton remodeling_RalB regulation pathway ²²	10.77	FLT4 KDR VEGFA VEGFC
22	miR-148a/miR-31/FIH1/HIF1andalpha;-Notch signaling in glioblastoma ¹	10.43	VEGFA VEGFC
23	VEGF binds to VEGFR leading to receptor dimerization ⁶⁶ Show member pathways VEGF ligand-receptor interactions ⁶⁶	10.13	FLT4 KDR VEGFA VEGFC

Sources

GO Terms for Lymphangioma

Cellular components related to Lymphangioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.43	ACTC1 HBA1 IFNA2 SERPINF1 VEGFA VEGFC
2	extracellular region	GO:0005576	9.17	FLT4 HBA1 IFNA2 KDR SERPINF1 VEGFA

Biological processes related to Lymphangioma according to GeneCards Suite gene sharing:

(show all 34)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of apoptotic process	GO:0043066	9.93	ACTC1 FLT4 KDR PDPN VEGFA
2	positive regulation of cell proliferation	GO:0008284	9.89	FLT4 KDR PROX1 VEGFA VEGFC
3	negative regulation of gene expression	GO:0010629	9.87	IFNA2 KDR SERPINF1 VEGFA
4	positive regulation of cell migration	GO:0030335	9.83	KDR PDPN VEGFA
5	angiogenesis	GO:0001525	9.83	FLT4 KDR VEGFA VEGFC
6	positive regulation of angiogenesis	GO:0045766	9.81	KDR VEGFA VEGFC
7	regulation of cell shape	GO:0008360	9.8	KDR PDPN VEGFA
8	kidney development	GO:0001822	9.79	PROX1 SERPINF1 VEGFA
9	lung development	GO:0030324	9.77	PDPN PROX1 VEGFA
10	positive regulation of protein phosphorylation	GO:0001934	9.73	FLT4 KDR VEGFA VEGFC
11	muscle filament sliding	GO:0030049	9.66	ACTC1 VIM
12	positive regulation of cell migration involved in sprouting angiogenesis	GO:0090050	9.66	KDR VEGFA
13	positive regulation of focal adhesion assembly	GO:0051894	9.65	KDR VEGFA
14	positive regulation of protein autophosphorylation	GO:0031954	9.65	VEGFA VEGFC
15	positive regulation of neuroblast proliferation	GO:0002052	9.64	VEGFA VEGFC
16	cell migration involved in sprouting angiogenesis	GO:0002042	9.64	KDR VEGFA
17	positive regulation of blood vessel endothelial cell migration	GO:0043536	9.63	KDR VEGFA VEGFC
18	induction of positive chemotaxis	GO:0050930	9.62	VEGFA VEGFC
19	skeletal muscle thin filament assembly	GO:0030240	9.62	ACTC1 PROX1
20	lymph vessel development	GO:0001945	9.61	FLT4 PROX1
21	positive regulation of positive chemotaxis	GO:0050927	9.6	KDR VEGFA
22	positive regulation of cellular component movement	GO:0051272	9.58	PDPN VEGFA
23	positive regulation of protein kinase C signaling	GO:0090037	9.58	FLT4 VEGFA
24	cellular response to vascular endothelial growth factor stimulus	GO:0035924	9.58	FLT4 KDR VEGFA
25	positive regulation of mast cell chemotaxis	GO:0060754	9.56	VEGFA VEGFC
26	vascular endothelial growth factor receptor signaling pathway	GO:0048010	9.56	FLT4 KDR VEGFA VEGFC
27	sprouting angiogenesis	GO:0002040	9.54	FLT4 VEGFA VEGFC
28	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	GO:0038033	9.51	KDR VEGFA
29	lymphangiogenesis	GO:0001946	9.5	FLT4 PDPN PROX1
30	actin-mediated cell contraction	GO:0070252	9.48	ACTC1 PDPN
31	positive regulation of endothelial cell migration	GO:0010595	9.46	FLT4 KDR PROX1 VEGFA
32	positive regulation of endothelial cell proliferation	GO:0001938	9.35	FLT4 KDR PROX1 VEGFA VEGFC
33	vascular endothelial growth factor signaling pathway	GO:0038084	8.92	FLT4 KDR VEGFA VEGFC
34	multicellular organism development	GO:0007275	10.02	KDR PDPN PROX1 SERPINF1 VEGFA VEGFC

Molecular functions related to Lymphangioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chemoattractant activity	GO:0042056	9.16	VEGFA VEGFC
2	vascular endothelial growth factor-activated receptor activity	GO:0005021	8.96	FLT4 KDR
3	vascular endothelial growth factor receptor 3 binding	GO:0043185	8.62	VEGFA VEGFC

Sources

Sources for Lymphangioma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia