Lymphangitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology: ¹¹ A lymphatic system disease that is characterized by inflammation of the lymphatic channels which occurs as a result of infection at a site distal to the channel. It is caused by Streptococcus pyogenes (Group A strep) or Staphylococcus aureus. Lymphangitis is also sometimes called blood poisoning.

MalaCards based summary: Lymphangitis, also known as inflammation of lymphatics, is related to elephantiasis and hereditary lymphedema i. An important gene associated with Lymphangitis is LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. Affiliated tissues include breast, lung and lymph node, and related phenotypes are homeostasis/metabolism and neoplasm

Wikipedia: ⁷⁵ Lymphangitis is an inflammation or an infection of the lymphatic channels that occurs as a result of... more...

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Related Diseases for Lymphangitis

Diseases related to Lymphangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 709)

#	Related Disease	Score	Top Affiliating Genes
1	elephantiasis	30.7	VEGFC FLT4 CD4
2	hereditary lymphedema i	30.2	VEGFD VEGFC PDPN LYVE1 FLT4
3	rectal benign neoplasm	30.2	KRT7 EGFR CEACAM5
4	cellulitis	30.0	FLT4 CRP CD4 ALB
5	krukenberg carcinoma	30.0	KRT7 CEACAM5
6	ascending colon cancer	30.0	KRT7 CEACAM5
7	benign mesothelioma	30.0	PDPN NKX2-1 KRT7 CEACAM5
8	lung benign neoplasm	30.0	NKX2-1 KRT7 EGFR
9	syphilis	30.0	CRP CD4 ALB
10	nocardiosis	30.0	CRP CD4
11	eccrine porocarcinoma	29.9	MUC1 KRT7 CEACAM5
12	peritoneal mesothelioma	29.9	PDPN KRT7 CEACAM5
13	lymphoepithelioma-like carcinoma	29.9	KRT7 EGFR ALK
14	respiratory failure	29.9	NKX2-1 CRP CD4 ALB
15	kaposi sarcoma	29.8	VEGFC PDPN LYVE1 FLT4
16	bile duct cysts	29.7	KRT7 CEACAM5 ALB
17	inflammatory myofibroblastic tumor	29.7	ROS1 EGFR ALK
18	miliary tuberculosis	29.7	CRP CD4 ALB
19	protein-losing enteropathy	29.7	CRP CD4 ALB
20	interstitial lung disease	29.6	NKX2-1 MUC1 EGFR CRP
21	sweat gland cancer	29.6	KRT7 ERBB2 CEACAM5
22	pneumothorax	29.5	NKX2-1 MUC1 CRP ALK
23	obstructive jaundice	29.5	KRT7 CRP CEACAM5 ALB
24	intestinal tuberculosis	29.5	CRP CD4 ALB
25	whipple disease	29.4	CRP CD4 ALB
26	scarlet fever	29.4	CRP CD4 ALB
27	fungal infectious disease	29.4	CRP CD4 ALB
28	bronchus cancer	29.4	KRT7 ERBB2 EGFR CEACAM5 ALK
29	colonic benign neoplasm	29.4	KRT7 ERBB2 EGFR CEACAM5 CD4
30	hydronephrosis	29.4	KRT7 CRP ALB
31	small cell carcinoma	29.4	NKX2-1 KRT7 EGFR CEACAM5 ALK
32	cervix carcinoma	29.3	KRT7 ERBB2 EGFR CEACAM5 CD4
33	duodenum cancer	29.2	MUC1 KRT7 ERBB2 CEACAM5
34	mammary paget's disease	29.2	MUC1 KRT7 ERBB2 CEACAM5
35	renal cell carcinoma, papillary, 1	29.2	PDPN KRT7 ERBB2 EGFR ALK
36	exanthem	29.1	ERBB2 EGFR CRP CD4 ALK ALB
37	lymphangioma	29.1	VEGFC PDPN LYVE1 KRT7 FLT4 EGFR
38	signet ring cell adenocarcinoma	29.0	PDPN MUC1 KRT7 ERBB2 CEACAM5
39	mesothelioma, malignant	29.0	PDPN NKX2-1 MUC1 KRT7 FLT4 CEACAM5
40	papillary carcinoma	29.0	VEGFC NKX2-1 MUC1 KRT7 ERBB2
41	ovary adenocarcinoma	29.0	MUC1 KRT7 ERBB2 EGFR CEACAM5
42	thyroid gland cancer	28.9	NKX2-1 KRT7 ERBB2 EGFR CEACAM5 ALK
43	breast ductal carcinoma	28.7	VEGFD VEGFC MUC1 KRT7 ERBB2 EGFR
44	peripheral nervous system disease	28.5	ERBB2 EGFR CRP CD4 ALK ALB
45	skin disease	28.5	ERBB2 EGFR CRP CD4 ALK ALB
46	mucinous adenocarcinoma	28.5	ROS1 NKX2-1 MUC1 KRT7 ERBB2 EGFR
47	gallbladder cancer	28.1	PDPN MUC1 KRT7 ERBB2 EGFR CEACAM5
48	breast adenocarcinoma	28.0	MUC1 KRT7 ERBB2 EGFR CEACAM5 CD4
49	gastric cancer	27.9	VEGFD VEGFC PDPN MUC1 FLT4 ERBB2
50	lung cancer susceptibility 3	27.9	VEGFD VEGFC ROS1 NKX2-1 MUC1 KRT7

Comorbidity relations with Lymphangitis via Phenotypic Disease Network (PDN):

Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Lymphangitis:

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Symptoms & Phenotypes for Lymphangitis

MGI Mouse Phenotypes related to Lymphangitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10	ALB ALK CD4 CEACAM5 CRP EGFR
2	neoplasm	MP:0002006	9.92	ALB ALK CEACAM5 EGFR ERBB2 MUC1
3	normal	MP:0002873	9.86	ALB ALK EGFR ERBB2 FLT4 MUC1
4	digestive/alimentary	MP:0005381	9.61	ALB CD4 CEACAM5 EGFR ERBB2 FLT4
5	cardiovascular system	MP:0005385	9.36	ALB CEACAM5 CRP EGFR ERBB2 FLT4

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Drugs & Therapeutics for Lymphangitis

Search Clinical Trials, NIH Clinical Center for Lymphangitis

Cochrane evidence based reviews: lymphangitis

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Genetic Tests for Lymphangitis

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Anatomical Context for Lymphangitis

Organs/tissues related to Lymphangitis:

MalaCards : Breast, Lung, Lymph Node, Skin, Cervix, Colon, Prostate

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Publications for Lymphangitis

Articles related to Lymphangitis:

(show top 50) (show all 1097)

#	Title	Authors	PMID	Year
1	Cutaneous lymphangitis carcinomatosa in salivary duct carcinoma. ⁶²	Uijen MJ...van Herpen CM	36347591	2022
2	Monkeypox infection with rapidly developing painful lymphangitis. ⁶²	Kreuter A...Wieland U	36371758	2022
3	Colorectal Cancer Stage at Diagnosis Before vs During the COVID-19 Pandemic in Italy. ⁶²	Rottoli M...COVID-Colorectal Cancer (CRC) Study Group	36409496	2022
4	Non-Venereal Sclerosing Lymphangitis of the Penis in a 35-Year-Old Saudi Male: A Case Report. ⁶²	Alrubaiaan MT...Alekrish KA	36475165	2022
5	Association between CA 15‑3 and progression of interstitial lung disease in a case of coexisting systemic sclerosis and recurrent breast cancer: A case report. ⁶²	Ohara M...Yoshida Y	36157317	2022
6	Pathophysiology, Diagnosis, and Management of Canine Intestinal Lymphangiectasia: A Comparative Review. ⁶²	Jablonski SA	36290177	2022
7	Long-term treatment with ALK inhibitors for postoperative recurrence of ALK-rearranged lung cancer. ⁶²	Kodama K...Kishima H	36186223	2022
8	Optimizing Antibiotic Treatment of Skin Infections in Pediatric Emergency and Urgent Care Centers. ⁶²	Wiltrakis SM...Jain S	36073197	2022
9	Long-term patency of multiple lymphatic-venous anastomoses in cancer-related lymphedema: A single center observational study. ⁶²	Boccardo F...Dessalvi S	35916247	2022
10	Uncommon defibrinogenation and coagulopathy caused by Trimeresurus stejnegeri stejnegeri envenomation in a patient with swelling above the ankle. ⁶²	Chen YH...Wen CY	35987354	2022
11	Risk Factors Associated with Adverse Outcomes after Ablative Surgery for Lymphedema. ⁶²	Kuruvilla AS...Krajewski A	36162422	2022
12	Lymphaticovenular Anastomosis: Superficial Venous Anatomical Approach. ⁶²	Winaikosol K...Surakunprapha P	36159382	2022
13	A Case of Autoimmune Pulmonary Alveolar Proteinosis with Suspected Exacerbation after Osimertinib Administration for Lung Cancer. ⁶²	Shimoda M...Ohta K	36070942	2022
14	Retrograde lymph flow in the lymphatic vessels in limb lymphedema. ⁶²	Mackie H...Koelmeyer LA	35714902	2022
15	Review of Malpractice Litigation in the Diagnosis and Treatment of Venous & Lymphatic Disease. ⁶²	Choinski K...Phair J	35926792	2022
16	[Duodenal lymphangitis carcinomatosa: a rare endoscopic finding]. ⁶²	List J	34169491	2022
17	Prevalence and risk factors of epizootic lymphangitis in cart pulling horses and mules in Central and South Gondar zones, Amhara region, Ethiopia. ⁶²	Molla AM...Fentahun T	35928106	2022
18	Surgical treatment of lower extremity lymphedema with subcutaneous implantation of silicone tubing. ⁶²	Cevirme D...Kaan Kirali M	36303685	2022
19	Complicated Ulceroglandular Tularemia. ⁶²	Brmbolic B...Karic U	36237562	2022
20	Pulmonary Lymphangitis Carcinomatosa Mimicking Immunotherapy-Related Interstitial Pneumonitis: A Case Report. ⁶²	Imakita T...Mio T	36157702	2022
21	Pulmonary tumour embolism and lymphangitis carcinomatosa: a case report and review of the literature. ⁶²	Engel J...Auer J	35525999	2022
22	Synchronous gallbladder metastasis originating from residual gastric cancer: a case report and the review of literature. ⁶²	Kawamoto A...Nishizaki T	35524891	2022
23	Cutaneous Lymphangitis Carcinomatosa: Dermoscopic and Reflectance Confocal Microscopy Features. ⁶²	Lopez-Trujillo E...Segura S	36386063	2022
24	Acute lymphangitis. ⁶²	Tai YL...Lin CY	35267196	2022
25	Pediatric tubular acute lymphangitis caused by Rickettsia sibirica mongolitimonae: Case report and literature review. ⁶²	Vazquez-Perez A...Santos-Perez JL	35473997	2022
26	Pulmonary Lymphangitis Poses a Major Challenge for Radiologists in an Oncological Setting during the COVID-19 Pandemic. ⁶²	Fusco R...Granata V	35455740	2022
27	Pulmonary inflammatory myofibroblastic tumor coexisting with lymphangitis carcinomatosis: Mimicking metastatic papillary thyroid carcinoma with nodular fasciitis-like stroma. ⁶²	Yadav SC...Rekhi B	35435385	2022
28	Evaluation of the degree and distribution of lymphangiectasia in full-thickness canine small intestinal specimens diagnosed with lymphoplasmacytic enteritis and granulomatous lymphangitis. ⁶²	Nagahara T...Tsujimoto H	35283405	2022
29	Long-term follow up after sentinel node biopsy alone for early-stage cervical cancer. ⁶²	Yahata H...Kato K	35151491	2022
30	Not only lymphadenopathy: case of chest lymphangitis assessed with MRI after COVID 19 vaccine. ⁶²	Granata V...Petrillo A	35300727	2022
31	Pulmonary lymphangitis sarcomatosis: a rare cause of severe progressive dyspnoea. ⁶²	Quigley D...McDonnell C	35241446	2022
32	Practical application of steroids in palliative therapy. ⁶²	Frank N...Csikos A	35184049	2022
33	Vulvar cancer in hidradenitis suppurativa. ⁶²	Vergeldt TFM...de Hullu JA	35106355	2022
34	A review of the ethnopharmacology, phytochemistry and pharmacology of Cynanchumatratum. ⁶²	Zhang Y...Chang YX	34662666	2022
35	Lymphatic flow through (LyFT) ALT flap: an original solution to reconstruct soft tissue loss with lymphatic leakage or lower limb lymphedema. ⁶²	Guillier D...di Summa PG	35189063	2022
36	A Case of Endonasal Endoscopic Surgery for Intraorbital Metastasis of Gastric Ring Cell Carcinoma. ⁶²	Tsuruta Y...Inohara H	32697105	2022
37	Objective Thoracoscopic Criteria in Differentiation between Benign and Malignant Pleural Effusions. ⁶²	Ellayeh M...Rahman N	34515216	2022
38	Lymphangitis carcinomatosa from gallbladder cancer. ⁶²	Kitahara Y...Nakano K	35309973	2022
39	Genomic profiling of non-small cell lung cancer with the rare pulmonary lymphangitic carcinomatosis and clinical outcome of the exploratory anlotinib treatment. ⁶²	Dong C...Fang S	36324591	2022
40	Lymphangitis Carcinomatosa in Neck Soft Tissue: Computed Tomography Findings With Emphasis on Differentiation From Cellulitis. ⁶²	Kim DG...Lee Y	35099146	2022
41	The efficacy of 99mTc-rituximab as a tracer for sentinel lymph node biopsy in cutaneous melanoma patients. ⁶²	Liu J...Si L	35282108	2022
42	Equine Histoplasmosis in Ethiopia: Phylogenetic Analysis by Sequencing of the Internal Transcribed Spacer Region of rRNA Genes. ⁶²	Ameni G...Sori T	35909976	2022
43	Epizootic lymphangitis: A neglected disease of working equids. ⁶²	Cabanes FJ	34961653	2022
44	Intrinsic subtypes and therapeutic decision-making in hormone receptor-positive/HER2-negative metastatic breast cancer with visceral crisis: A case report. ⁶²	Schettini F...Vidal M	36425558	2022
45	Ileitis-associated tertiary lymphoid organs arise at lymphatic valves and impede mesenteric lymph flow in response to tumor necrosis factor. ⁶²	Czepielewski RS...Randolph GJ	34788601	2021
46	Physical therapies in the decongestive treatment of lymphedema: A randomized, non-inferiority controlled study. ⁶²	Forner-Cordero I...Rel-Monzo P	34514891	2021
47	A case report of RASA1-associated inherited lymphoedema with recurrent life-threatening lymphangitis. ⁶²	Westphal DS...Ibrahim T	34859188	2021
48	A comparative pan-genomic analysis of 53 C. pseudotuberculosis strains based on functional domains. ⁶²	Bernardes JS...Coronado MA	32779519	2021
49	Breast Carcinomatous Lymphangitis as an Unusual Presentation of Ovarian Cancer. ⁶²	Muoio B...Del Grande M	34829453	2021
50	Acute Lymphangitis after a Land Leech Bite. ⁶²	Ono S...Nishio K	34092727	2021

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Genes for Lymphangitis

Genes related to Lymphangitis (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	LYVE1	Lymphatic Vessel Endothelial Hyaluronan Receptor 1	Protein Coding	5.81	DISEASES inferred ¹⁴
2	CRP	C-Reactive Protein	Protein Coding	5.71	DISEASES inferred ¹⁴
3	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	5.6	DISEASES inferred ¹⁴
4	PDPN	Podoplanin	Protein Coding	5.27	DISEASES inferred ¹⁴
5	VEGFC	Vascular Endothelial Growth Factor C	Protein Coding	5.21	DISEASES inferred ¹⁴
6	FLT4	Fms Related Receptor Tyrosine Kinase 4	Protein Coding	5.14	DISEASES inferred ¹⁴
7	KRT7	Keratin 7	Protein Coding	5.11	DISEASES inferred ¹⁴
8	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	5.04	DISEASES inferred ¹⁴
9	EGFR	Epidermal Growth Factor Receptor	Protein Coding	5.04	DISEASES inferred ¹⁴
10	NKX2-1	NK2 Homeobox 1	Protein Coding	4.98	DISEASES inferred ¹⁴
11	CD4	CD4 Molecule	Protein Coding	4.97	DISEASES inferred ¹⁴
12	VEGFD	Vascular Endothelial Growth Factor D	Protein Coding	4.96	DISEASES inferred ¹⁴
13	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	4.94	DISEASES inferred ¹⁴
14	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	4.86	DISEASES inferred ¹⁴
15	ALB	Albumin	Protein Coding	4.81	DISEASES inferred ¹⁴
16	ROS1	ROS Proto-Oncogene 1, Receptor Tyrosine Kinase	Protein Coding	4.79	DISEASES inferred ¹⁴

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Variations for Lymphangitis

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Expression for Lymphangitis

Search GEO for disease gene expression data for Lymphangitis.

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Pathways for Lymphangitis

Pathways related to Lymphangitis according to GeneCards Suite gene sharing:

(show all 21)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.58	VEGFD VEGFC ROS1 MUC1 FLT4 ERBB2
2	GPCR Pathway ⁶⁴ Show member pathways Breast Cancer Regulation by Stathmin1 ⁶⁴ Estrogen Pathway ⁶⁴ NFAT in Immune Response ⁶⁴ P2Y Receptor Signaling ⁶⁴ Pancreatic Adenocarcinoma ⁶⁴ Paxillin Interactions ⁶⁴ Ras Pathway ⁶⁴	13.52	ALK CD4 EGFR ERBB2 FLT4 ROS1
3	Activation of cAMP-Dependent PKA ⁶⁴ Show member pathways Activation of PKA through GPCR ⁶⁴ cAMP Pathway ⁶⁴ PKA Signaling ⁶⁴	13.37	VEGFD VEGFC ROS1 FLT4 ERBB2 EGFR
4	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.33	ALK CD4 EGFR ERBB2 FLT4 ROS1
5	CREB Pathway ⁶⁴ Show member pathways Activation of PKC through GPCR ⁶⁴ Intracellular Calcium Signaling ⁶⁴ IP3 Pathway ⁶⁴	13.15	VEGFD VEGFC ROS1 FLT4 ERBB2 EGFR
6	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.13	VEGFD VEGFC FLT4 ERBB2 EGFR CD4
7	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.12	ALK CD4 EGFR ERBB2 FLT4 ROS1
8	Nanog in Mammalian ESC Pluripotency ⁶⁴ Show member pathways 14-3-3 Induced Intracellular Signaling ⁶⁴ eNOS Signaling ⁶⁴ GSK3 Signaling ⁶⁴	13.03	VEGFD VEGFC ROS1 FLT4 ERBB2 EGFR
9	Actin Nucleation by ARP-WASP Complex ⁶⁴ Show member pathways Actin Nucleation and Branching ⁶⁴ CDC42 Pathway ⁶⁴ RhoA Pathway ⁶⁴	12.79	ROS1 FLT4 ERBB2 EGFR ALK
10	Signaling by Receptor Tyrosine Kinases ⁶⁶	12.52	VEGFD VEGFC FLT4 ERBB2 EGFR ALK
11	VEGF Pathway (Qiagen) ⁶⁴ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶⁴ Development VEGF-family signaling ²² Neurophilin interactions with VEGF and VEGFR ⁶⁶ VEGF and VEGFR signaling network ⁶¹ VEGF Family Ligands and Receptor Interactions ⁶⁴	12.29	VEGFD VEGFC FLT4 EGFR
12	RhoGDI Pathway ⁶⁴ Show member pathways Fc-GammaR-Mediated Phagocytosis in Macrophages ⁶⁴	12.25	VEGFD VEGFC FLT4 EGFR
13	Focal adhesion ⁷⁴	12.13	VEGFD VEGFC ERBB2 EGFR
14	G-protein signaling RAC1 in cellular process ²² Show member pathways CDC42 signaling events ⁶¹ Cytoskeleton remodeling CDC42 in cellular processes ²² RAC1 signaling pathway ⁶¹	11.79	VEGFD VEGFC ROS1 FLT4 ERBB2 EGFR
15	Angiogenesis (CST) ³	11.7	VEGFC PDPN FLT4
16	G-protein signaling_RhoA regulation pathway ²²	11.58	VEGFD VEGFC ERBB2 EGFR
17	Tyrosine Kinases / Adaptors ³	11.27	VEGFC ROS1 FLT4 ERBB2 EGFR ALK
18	Cell adhesion_Cell-matrix glycoconjugates ²²	11.24	MUC1 LYVE1 CEACAM5
19	VEGFR3 signaling in lymphatic endothelium ⁶¹	10.96	VEGFD VEGFC FLT4
20	VEGF ligand-receptor interactions ⁶⁶ Show member pathways VEGF binds to VEGFR leading to receptor dimerization ⁶⁶	10.64	VEGFD VEGFC FLT4
21	G-protein signaling_Rap2B regulation pathway ²²	10.6	VEGFD VEGFC ROS1 FLT4 ERBB2 EGFR

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GO Terms for Lymphangitis

Cellular components related to Lymphangitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	9.8	ROS1 PDPN MUC1 LYVE1 FLT4 ERBB2
2	plasma membrane	GO:0005887	9.8	ROS1 PDPN MUC1 LYVE1 FLT4 ERBB2
3	receptor complex	GO:0043235	9.65	ROS1 FLT4 ERBB2 EGFR ALK

Biological processes related to Lymphangitis according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of apoptotic process	GO:0043066	10.24	ALB CEACAM5 EGFR ERBB2 FLT4 PDPN
2	protein autophosphorylation	GO:0046777	10.14	FLT4 ERBB2 EGFR ALK
3	positive regulation of MAPK cascade	GO:0043410	10.13	FLT4 ERBB2 CD4 ALK
4	positive regulation of protein phosphorylation	GO:0001934	10.1	VEGFD VEGFC FLT4 ERBB2 EGFR CD4
5	sprouting angiogenesis	GO:0002040	9.95	VEGFD VEGFC FLT4
6	vascular endothelial growth factor receptor signaling pathway	GO:0048010	9.93	VEGFD VEGFC FLT4
7	regulation of ERK1 and ERK2 cascade	GO:0070372	9.91	ROS1 ERBB2 EGFR
8	peptidyl-tyrosine phosphorylation	GO:0018108	9.9	ALK CD4 EGFR ERBB2 FLT4 ROS1
9	ERBB2-EGFR signaling pathway	GO:0038134	9.86	ERBB2 EGFR
10	enzyme-linked receptor protein signaling pathway	GO:0007167	9.85	ERBB2 CD4
11	vascular endothelial growth factor signaling pathway	GO:0038084	9.85	VEGFD VEGFC FLT4
12	positive regulation of mast cell chemotaxis	GO:0060754	9.81	VEGFD VEGFC
13	peptidyl-tyrosine autophosphorylation	GO:0038083	9.8	ALK EGFR ROS1
14	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.73	ROS1 FLT4 ERBB2 EGFR CD4 ALK
15	multicellular organism development	GO:0007275	9.65	ROS1 FLT4 ERBB2 EGFR ALK
16	positive regulation of kinase activity	GO:0033674	9.4	ROS1 FLT4 ERBB2 EGFR CD4 ALK

Molecular functions related to Lymphangitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein phosphatase binding	GO:0019903	9.86	ROS1 FLT4 ERBB2 EGFR
2	protein kinase activity	GO:0004672	9.77	ROS1 FLT4 ERBB2 EGFR ALK
3	vascular endothelial growth factor receptor binding	GO:0005172	9.62	VEGFD VEGFC
4	protein tyrosine kinase activity	GO:0004713	9.61	ROS1 FLT4 ERBB2 EGFR ALK
5	vascular endothelial growth factor receptor 3 binding	GO:0043185	9.46	VEGFD VEGFC
6	transmembrane receptor protein tyrosine kinase activity	GO:0004714	9.32	ROS1 FLT4 ERBB2 EGFR ALK

Sources

Sources for Lymphangitis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LYM014 MIFTS: 42	Lymphangitis Categories: Blood diseases, Cardiovascular diseases, Immune diseases	Data Licensing For inquiries, contact: [email protected]
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