MCID: LYM014
MIFTS: 42

Lymphangitis

Categories: Blood diseases, Cardiovascular diseases, Immune diseases
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Aliases & Classifications for Lymphangitis

Summaries for Lymphangitis

Disease Ontology: 11 A lymphatic system disease that is characterized by inflammation of the lymphatic channels which occurs as a result of infection at a site distal to the channel. It is caused by Streptococcus pyogenes (Group A strep) or Staphylococcus aureus. Lymphangitis is also sometimes called blood poisoning.

MalaCards based summary: Lymphangitis, also known as inflammation of lymphatics, is related to elephantiasis and hereditary lymphedema i. An important gene associated with Lymphangitis is LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. Affiliated tissues include breast, lung and lymph node, and related phenotypes are homeostasis/metabolism and neoplasm

Wikipedia: 75 Lymphangitis is an inflammation or an infection of the lymphatic channels that occurs as a result of... more...

Related Diseases for Lymphangitis

Diseases related to Lymphangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 709)
# Related Disease Score Top Affiliating Genes
1 elephantiasis 30.7 VEGFC FLT4 CD4
2 hereditary lymphedema i 30.2 VEGFD VEGFC PDPN LYVE1 FLT4
3 rectal benign neoplasm 30.2 KRT7 EGFR CEACAM5
4 cellulitis 30.0 FLT4 CRP CD4 ALB
5 krukenberg carcinoma 30.0 KRT7 CEACAM5
6 ascending colon cancer 30.0 KRT7 CEACAM5
7 benign mesothelioma 30.0 PDPN NKX2-1 KRT7 CEACAM5
8 lung benign neoplasm 30.0 NKX2-1 KRT7 EGFR
9 syphilis 30.0 CRP CD4 ALB
10 nocardiosis 30.0 CRP CD4
11 eccrine porocarcinoma 29.9 MUC1 KRT7 CEACAM5
12 peritoneal mesothelioma 29.9 PDPN KRT7 CEACAM5
13 lymphoepithelioma-like carcinoma 29.9 KRT7 EGFR ALK
14 respiratory failure 29.9 NKX2-1 CRP CD4 ALB
15 kaposi sarcoma 29.8 VEGFC PDPN LYVE1 FLT4
16 bile duct cysts 29.7 KRT7 CEACAM5 ALB
17 inflammatory myofibroblastic tumor 29.7 ROS1 EGFR ALK
18 miliary tuberculosis 29.7 CRP CD4 ALB
19 protein-losing enteropathy 29.7 CRP CD4 ALB
20 interstitial lung disease 29.6 NKX2-1 MUC1 EGFR CRP
21 sweat gland cancer 29.6 KRT7 ERBB2 CEACAM5
22 pneumothorax 29.5 NKX2-1 MUC1 CRP ALK
23 obstructive jaundice 29.5 KRT7 CRP CEACAM5 ALB
24 intestinal tuberculosis 29.5 CRP CD4 ALB
25 whipple disease 29.4 CRP CD4 ALB
26 scarlet fever 29.4 CRP CD4 ALB
27 fungal infectious disease 29.4 CRP CD4 ALB
28 bronchus cancer 29.4 KRT7 ERBB2 EGFR CEACAM5 ALK
29 colonic benign neoplasm 29.4 KRT7 ERBB2 EGFR CEACAM5 CD4
30 hydronephrosis 29.4 KRT7 CRP ALB
31 small cell carcinoma 29.4 NKX2-1 KRT7 EGFR CEACAM5 ALK
32 cervix carcinoma 29.3 KRT7 ERBB2 EGFR CEACAM5 CD4
33 duodenum cancer 29.2 MUC1 KRT7 ERBB2 CEACAM5
34 mammary paget's disease 29.2 MUC1 KRT7 ERBB2 CEACAM5
35 renal cell carcinoma, papillary, 1 29.2 PDPN KRT7 ERBB2 EGFR ALK
36 exanthem 29.1 ERBB2 EGFR CRP CD4 ALK ALB
37 lymphangioma 29.1 VEGFC PDPN LYVE1 KRT7 FLT4 EGFR
38 signet ring cell adenocarcinoma 29.0 PDPN MUC1 KRT7 ERBB2 CEACAM5
39 mesothelioma, malignant 29.0 PDPN NKX2-1 MUC1 KRT7 FLT4 CEACAM5
40 papillary carcinoma 29.0 VEGFC NKX2-1 MUC1 KRT7 ERBB2
41 ovary adenocarcinoma 29.0 MUC1 KRT7 ERBB2 EGFR CEACAM5
42 thyroid gland cancer 28.9 NKX2-1 KRT7 ERBB2 EGFR CEACAM5 ALK
43 breast ductal carcinoma 28.7 VEGFD VEGFC MUC1 KRT7 ERBB2 EGFR
44 peripheral nervous system disease 28.5 ERBB2 EGFR CRP CD4 ALK ALB
45 skin disease 28.5 ERBB2 EGFR CRP CD4 ALK ALB
46 mucinous adenocarcinoma 28.5 ROS1 NKX2-1 MUC1 KRT7 ERBB2 EGFR
47 gallbladder cancer 28.1 PDPN MUC1 KRT7 ERBB2 EGFR CEACAM5
48 breast adenocarcinoma 28.0 MUC1 KRT7 ERBB2 EGFR CEACAM5 CD4
49 gastric cancer 27.9 VEGFD VEGFC PDPN MUC1 FLT4 ERBB2
50 lung cancer susceptibility 3 27.9 VEGFD VEGFC ROS1 NKX2-1 MUC1 KRT7

Comorbidity relations with Lymphangitis via Phenotypic Disease Network (PDN):


Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Lymphangitis:



Diseases related to Lymphangitis

Symptoms & Phenotypes for Lymphangitis

MGI Mouse Phenotypes related to Lymphangitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10 ALB ALK CD4 CEACAM5 CRP EGFR
2 neoplasm MP:0002006 9.92 ALB ALK CEACAM5 EGFR ERBB2 MUC1
3 normal MP:0002873 9.86 ALB ALK EGFR ERBB2 FLT4 MUC1
4 digestive/alimentary MP:0005381 9.61 ALB CD4 CEACAM5 EGFR ERBB2 FLT4
5 cardiovascular system MP:0005385 9.36 ALB CEACAM5 CRP EGFR ERBB2 FLT4

Drugs & Therapeutics for Lymphangitis

Search Clinical Trials, NIH Clinical Center for Lymphangitis

Cochrane evidence based reviews: lymphangitis

Genetic Tests for Lymphangitis

Anatomical Context for Lymphangitis

Organs/tissues related to Lymphangitis:

MalaCards : Breast, Lung, Lymph Node, Skin, Cervix, Colon, Prostate

Publications for Lymphangitis

Articles related to Lymphangitis:

(show top 50) (show all 1097)
# Title Authors PMID Year
1
Cutaneous lymphangitis carcinomatosa in salivary duct carcinoma. 62
36347591 2022
2
Monkeypox infection with rapidly developing painful lymphangitis. 62
36371758 2022
3
Colorectal Cancer Stage at Diagnosis Before vs During the COVID-19 Pandemic in Italy. 62
36409496 2022
4
Non-Venereal Sclerosing Lymphangitis of the Penis in a 35-Year-Old Saudi Male: A Case Report. 62
36475165 2022
5
Association between CA 15‑3 and progression of interstitial lung disease in a case of coexisting systemic sclerosis and recurrent breast cancer: A case report. 62
36157317 2022
6
Pathophysiology, Diagnosis, and Management of Canine Intestinal Lymphangiectasia: A Comparative Review. 62
36290177 2022
7
Long-term treatment with ALK inhibitors for postoperative recurrence of ALK-rearranged lung cancer. 62
36186223 2022
8
Optimizing Antibiotic Treatment of Skin Infections in Pediatric Emergency and Urgent Care Centers. 62
36073197 2022
9
Long-term patency of multiple lymphatic-venous anastomoses in cancer-related lymphedema: A single center observational study. 62
35916247 2022
10
Uncommon defibrinogenation and coagulopathy caused by Trimeresurus stejnegeri stejnegeri envenomation in a patient with swelling above the ankle. 62
35987354 2022
11
Risk Factors Associated with Adverse Outcomes after Ablative Surgery for Lymphedema. 62
36162422 2022
12
Lymphaticovenular Anastomosis: Superficial Venous Anatomical Approach. 62
36159382 2022
13
A Case of Autoimmune Pulmonary Alveolar Proteinosis with Suspected Exacerbation after Osimertinib Administration for Lung Cancer. 62
36070942 2022
14
Retrograde lymph flow in the lymphatic vessels in limb lymphedema. 62
35714902 2022
15
Review of Malpractice Litigation in the Diagnosis and Treatment of Venous & Lymphatic Disease. 62
35926792 2022
16
[Duodenal lymphangitis carcinomatosa: a rare endoscopic finding]. 62
34169491 2022
17
Prevalence and risk factors of epizootic lymphangitis in cart pulling horses and mules in Central and South Gondar zones, Amhara region, Ethiopia. 62
35928106 2022
18
Surgical treatment of lower extremity lymphedema with subcutaneous implantation of silicone tubing. 62
36303685 2022
19
Complicated Ulceroglandular Tularemia. 62
36237562 2022
20
Pulmonary Lymphangitis Carcinomatosa Mimicking Immunotherapy-Related Interstitial Pneumonitis: A Case Report. 62
36157702 2022
21
Pulmonary tumour embolism and lymphangitis carcinomatosa: a case report and review of the literature. 62
35525999 2022
22
Synchronous gallbladder metastasis originating from residual gastric cancer: a case report and the review of literature. 62
35524891 2022
23
Cutaneous Lymphangitis Carcinomatosa: Dermoscopic and Reflectance Confocal Microscopy Features. 62
36386063 2022
24
Acute lymphangitis. 62
35267196 2022
25
Pediatric tubular acute lymphangitis caused by Rickettsia sibirica mongolitimonae: Case report and literature review. 62
35473997 2022
26
Pulmonary Lymphangitis Poses a Major Challenge for Radiologists in an Oncological Setting during the COVID-19 Pandemic. 62
35455740 2022
27
Pulmonary inflammatory myofibroblastic tumor coexisting with lymphangitis carcinomatosis: Mimicking metastatic papillary thyroid carcinoma with nodular fasciitis-like stroma. 62
35435385 2022
28
Evaluation of the degree and distribution of lymphangiectasia in full-thickness canine small intestinal specimens diagnosed with lymphoplasmacytic enteritis and granulomatous lymphangitis. 62
35283405 2022
29
Long-term follow up after sentinel node biopsy alone for early-stage cervical cancer. 62
35151491 2022
30
Not only lymphadenopathy: case of chest lymphangitis assessed with MRI after COVID 19 vaccine. 62
35300727 2022
31
Pulmonary lymphangitis sarcomatosis: a rare cause of severe progressive dyspnoea. 62
35241446 2022
32
Practical application of steroids in palliative therapy. 62
35184049 2022
33
Vulvar cancer in hidradenitis suppurativa. 62
35106355 2022
34
A review of the ethnopharmacology, phytochemistry and pharmacology of Cynanchumatratum. 62
34662666 2022
35
Lymphatic flow through (LyFT) ALT flap: an original solution to reconstruct soft tissue loss with lymphatic leakage or lower limb lymphedema. 62
35189063 2022
36
A Case of Endonasal Endoscopic Surgery for Intraorbital Metastasis of Gastric Ring Cell Carcinoma. 62
32697105 2022
37
Objective Thoracoscopic Criteria in Differentiation between Benign and Malignant Pleural Effusions. 62
34515216 2022
38
Lymphangitis carcinomatosa from gallbladder cancer. 62
35309973 2022
39
Genomic profiling of non-small cell lung cancer with the rare pulmonary lymphangitic carcinomatosis and clinical outcome of the exploratory anlotinib treatment. 62
36324591 2022
40
Lymphangitis Carcinomatosa in Neck Soft Tissue: Computed Tomography Findings With Emphasis on Differentiation From Cellulitis. 62
35099146 2022
41
The efficacy of 99mTc-rituximab as a tracer for sentinel lymph node biopsy in cutaneous melanoma patients. 62
35282108 2022
42
Equine Histoplasmosis in Ethiopia: Phylogenetic Analysis by Sequencing of the Internal Transcribed Spacer Region of rRNA Genes. 62
35909976 2022
43
Epizootic lymphangitis: A neglected disease of working equids. 62
34961653 2022
44
Intrinsic subtypes and therapeutic decision-making in hormone receptor-positive/HER2-negative metastatic breast cancer with visceral crisis: A case report. 62
36425558 2022
45
Ileitis-associated tertiary lymphoid organs arise at lymphatic valves and impede mesenteric lymph flow in response to tumor necrosis factor. 62
34788601 2021
46
Physical therapies in the decongestive treatment of lymphedema: A randomized, non-inferiority controlled study. 62
34514891 2021
47
A case report of RASA1-associated inherited lymphoedema with recurrent life-threatening lymphangitis. 62
34859188 2021
48
A comparative pan-genomic analysis of 53 C. pseudotuberculosis strains based on functional domains. 62
32779519 2021
49
Breast Carcinomatous Lymphangitis as an Unusual Presentation of Ovarian Cancer. 62
34829453 2021
50
Acute Lymphangitis after a Land Leech Bite. 62
34092727 2021

Variations for Lymphangitis

Expression for Lymphangitis

Search GEO for disease gene expression data for Lymphangitis.

Pathways for Lymphangitis

Pathways related to Lymphangitis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.58 VEGFD VEGFC ROS1 MUC1 FLT4 ERBB2
2
Show member pathways
13.52 ALK CD4 EGFR ERBB2 FLT4 ROS1
3
Show member pathways
13.37 VEGFD VEGFC ROS1 FLT4 ERBB2 EGFR
4
Show member pathways
13.33 ALK CD4 EGFR ERBB2 FLT4 ROS1
5
Show member pathways
13.15 VEGFD VEGFC ROS1 FLT4 ERBB2 EGFR
6
Show member pathways
13.13 VEGFD VEGFC FLT4 ERBB2 EGFR CD4
7
Show member pathways
13.12 ALK CD4 EGFR ERBB2 FLT4 ROS1
8
Show member pathways
13.03 VEGFD VEGFC ROS1 FLT4 ERBB2 EGFR
9
Show member pathways
12.79 ROS1 FLT4 ERBB2 EGFR ALK
10 12.52 VEGFD VEGFC FLT4 ERBB2 EGFR ALK
11
Show member pathways
12.29 VEGFD VEGFC FLT4 EGFR
12
Show member pathways
12.25 VEGFD VEGFC FLT4 EGFR
13 12.13 VEGFD VEGFC ERBB2 EGFR
14
Show member pathways
11.79 VEGFD VEGFC ROS1 FLT4 ERBB2 EGFR
15 11.7 VEGFC PDPN FLT4
16 11.58 VEGFD VEGFC ERBB2 EGFR
17 11.27 VEGFC ROS1 FLT4 ERBB2 EGFR ALK
18 11.24 MUC1 LYVE1 CEACAM5
19 10.96 VEGFD VEGFC FLT4
20
Show member pathways
10.64 VEGFD VEGFC FLT4
21 10.6 VEGFD VEGFC ROS1 FLT4 ERBB2 EGFR

GO Terms for Lymphangitis

Cellular components related to Lymphangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.8 ROS1 PDPN MUC1 LYVE1 FLT4 ERBB2
2 plasma membrane GO:0005887 9.8 ROS1 PDPN MUC1 LYVE1 FLT4 ERBB2
3 receptor complex GO:0043235 9.65 ROS1 FLT4 ERBB2 EGFR ALK

Biological processes related to Lymphangitis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 10.24 ALB CEACAM5 EGFR ERBB2 FLT4 PDPN
2 protein autophosphorylation GO:0046777 10.14 FLT4 ERBB2 EGFR ALK
3 positive regulation of MAPK cascade GO:0043410 10.13 FLT4 ERBB2 CD4 ALK
4 positive regulation of protein phosphorylation GO:0001934 10.1 VEGFD VEGFC FLT4 ERBB2 EGFR CD4
5 sprouting angiogenesis GO:0002040 9.95 VEGFD VEGFC FLT4
6 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.93 VEGFD VEGFC FLT4
7 regulation of ERK1 and ERK2 cascade GO:0070372 9.91 ROS1 ERBB2 EGFR
8 peptidyl-tyrosine phosphorylation GO:0018108 9.9 ALK CD4 EGFR ERBB2 FLT4 ROS1
9 ERBB2-EGFR signaling pathway GO:0038134 9.86 ERBB2 EGFR
10 enzyme-linked receptor protein signaling pathway GO:0007167 9.85 ERBB2 CD4
11 vascular endothelial growth factor signaling pathway GO:0038084 9.85 VEGFD VEGFC FLT4
12 positive regulation of mast cell chemotaxis GO:0060754 9.81 VEGFD VEGFC
13 peptidyl-tyrosine autophosphorylation GO:0038083 9.8 ALK EGFR ROS1
14 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.73 ROS1 FLT4 ERBB2 EGFR CD4 ALK
15 multicellular organism development GO:0007275 9.65 ROS1 FLT4 ERBB2 EGFR ALK
16 positive regulation of kinase activity GO:0033674 9.4 ROS1 FLT4 ERBB2 EGFR CD4 ALK

Molecular functions related to Lymphangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein phosphatase binding GO:0019903 9.86 ROS1 FLT4 ERBB2 EGFR
2 protein kinase activity GO:0004672 9.77 ROS1 FLT4 ERBB2 EGFR ALK
3 vascular endothelial growth factor receptor binding GO:0005172 9.62 VEGFD VEGFC
4 protein tyrosine kinase activity GO:0004713 9.61 ROS1 FLT4 ERBB2 EGFR ALK
5 vascular endothelial growth factor receptor 3 binding GO:0043185 9.46 VEGFD VEGFC
6 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.32 ROS1 FLT4 ERBB2 EGFR ALK

Sources for Lymphangitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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