MCID: LYM014
MIFTS: 41

Lymphangitis

Categories: Blood diseases, Cardiovascular diseases, Immune diseases

Aliases & Classifications for Lymphangitis

MalaCards integrated aliases for Lymphangitis:

Name: Lymphangitis 12 43 15 17 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:9317
ICD9CM 34 457.2
MeSH 43 D008205
NCIt 49 C34790
SNOMED-CT 67 1415005
ICD10 32 I89.1
UMLS 71 C0024225

Summaries for Lymphangitis

Disease Ontology : 12 A lymphatic system disease that is characterized by inflammation of the lymphatic channels which occurs as a result of infection at a site distal to the channel. It is caused by Streptococcus pyogenes (Group A strep) or Staphylococcus aureus. Lymphangitis is also sometimes called blood poisoning.

MalaCards based summary : Lymphangitis is related to benign mesothelioma and hereditary lymphedema i. An important gene associated with Lymphangitis is SIGLEC5 (Sialic Acid Binding Ig Like Lectin 5), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Angiogenesis (CST). The drugs Clavulanate and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and skin, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 Lymphangitis is an inflammation or an infection of the lymphatic channels that occurs as a result of... more...

Related Diseases for Lymphangitis

Diseases related to Lymphangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 331)
# Related Disease Score Top Affiliating Genes
1 benign mesothelioma 30.6 PECAM1 CEACAM5
2 hereditary lymphedema i 30.5 VEGFC PROX1 PDPN FLT4
3 filariasis 30.3 FLT4 CRP ALB
4 mucinous adenocarcinoma 29.9 NKX2-1 CEACAM5 ALK
5 gastric adenocarcinoma 29.8 VEGFD VEGFC FLT4 CRP CEACAM5
6 pneumothorax 29.7 NKX2-1 CRP ALK
7 adenocarcinoma 29.6 VEGFD VEGFC NKX2-1 CEACAM5 ALK
8 lung disease 29.0 NKX2-1 CRP CEACAM5 ALB
9 lymphangioma 28.9 VEGFC PROX1 PECAM1 PDPN LYVE1 FLT4
10 lung cancer susceptibility 3 28.6 VEGFD VEGFC PECAM1 NKX2-1 FLT4 CEACAM5
11 renal cell carcinoma, nonpapillary 28.4 VEGFD VEGFC PECAM1 NKX2-1 FLT4
12 lymphogranuloma venereum 11.5
13 vasculitis 11.5
14 melioidosis 11.3
15 mesenteric lymphadenitis 11.2
16 filarial elephantiasis 11.2
17 milker's nodule 11.2
18 mucinous cystadenocarcinoma of the pancreas 10.5 VEGFC PDPN
19 conjunctival squamous cell carcinoma 10.5 PDPN LYVE1
20 epiglottitis 10.5 SIGLEC5 CRP
21 gallbladder papillary carcinoma 10.4 PDPN CEACAM5
22 mature teratoma of the ovary 10.4 SIGLEC5 CEACAM5
23 esophageal adenoid cystic carcinoma 10.4 PDPN CEACAM5
24 external ear carcinoma 10.4 CRP CEACAM5
25 bacterial conjunctivitis 10.4 SIGLEC5 CRP
26 pericardial tuberculosis 10.4 CRP CEACAM5
27 marantic endocarditis 10.4 CRP CEACAM5
28 xanthogranulomatous cholecystitis 10.4 PDPN CEACAM5
29 intramuscular hemangioma 10.4 PECAM1 LYVE1
30 eccrine papillary adenocarcinoma 10.4 PDPN CEACAM5
31 elephantiasis 10.4
32 orbital lymphangioma 10.4 PDPN FLT4
33 paratesticular lipoma 10.4 CEACAM5 ALK
34 lipoma of spermatic cord 10.4 CEACAM5 ALK
35 pustulosis of palm and sole 10.4 SIGLEC5 CRP
36 pleural lipoma 10.4 CEACAM5 ALK
37 cholecystolithiasis 10.4 CRP CEACAM5
38 eccrine mixed tumor of skin 10.4 PECAM1 CEACAM5
39 histoplasmosis 10.4
40 maxillary sinusitis 10.4 PDPN CRP
41 lymphatic malformation 1 10.3 VEGFC FLT4
42 acute dacryoadenitis 10.3 HECTD4 CRP
43 respiratory failure 10.3
44 intravascular fasciitis 10.3 PECAM1 ALK
45 neurogenic arthropathy 10.3 HECTD4 CRP
46 cellulitis 10.3
47 lymphangiectasis 10.3
48 intestinal tuberculosis 10.3 CRP ALB
49 calcific tendinitis 10.3 HECTD4 CRP
50 hereditary lymphedema ii 10.3 PROX1 FLT4

Comorbidity relations with Lymphangitis via Phenotypic Disease Network (PDN):


Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Lymphangitis:



Diseases related to Lymphangitis

Symptoms & Phenotypes for Lymphangitis

MGI Mouse Phenotypes related to Lymphangitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 ALB CRP FLT4 LYVE1 NKX2-1 PDPN
2 homeostasis/metabolism MP:0005376 9.36 ALB ALK CRP FLT4 GPT2 NKX2-1

Drugs & Therapeutics for Lymphangitis

Drugs for Lymphangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clavulanate Approved, Vet_approved 58001-44-8 5280980
2
Amoxicillin Approved, Vet_approved 26787-78-0 33613
3
Cefazolin Approved 25953-19-9 656510 33255
4
Cefuroxime Approved 55268-75-2 5479529 5361202
5 Amoxicillin-Potassium Clavulanate Combination
6 beta-Lactamase Inhibitors
7 Anti-Infective Agents
8 Anti-Bacterial Agents
9 Anesthetics
10 cefuroxime axetil
11 Cephalosporins
12 Antibiotics, Antitubercular

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The CORE Study (Chemotherapy OR Endocrine Treatment First?) A Randomized Study by the Scandinavian Breast Group [CORE] Withdrawn NCT00403182 Phase 3 chemotherapy;letrozole
2 Biliary Tissue Sampling Using a Cytology Brush or the G.I.U.M. Catheter: a Prospective Randomized Controlled Study. Unknown status NCT00160836 Phase 1
3 Evaluation of Peripheral Intravenous Catheter and Urinary Catheters Present on Admission to the "Maladies Infectieuses aiguës" Department. Unknown status NCT03329768
4 Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) Completed NCT01406275 Amoxicillin and clavulanate
5 Histologic Analysis of the Lymphatic Collecting Vessels Used for Minimally Invasive Supermicrosurgical Lymphatico-venous Anastomoses in the Treatment of Lymphedema Recruiting NCT03465930
6 Effect of Small Bowel Crohn's Disease on Chylomicron Secretion After Ingestion of a Fatty Meal Recruiting NCT03496818
7 Axillary Reverse Mapping (ARM). Identification of the Arm Lymphatic Pathways in Breast Cancer Surgery to Prevent Breast Cancer Related Lymphedema (BCRL): a Randomized Clinical Trial. Recruiting NCT03333226
8 Comparison of the Cosmetic Results, Quality of Life and Patient Satisfaction Achieved With Round-block and Retroglandular Oncoplastic Breast Conserving Surgeries. Response-adaptive (RAR) Prospective Randomised, Comperative Clinical Study Recruiting NCT04349527
9 Examining the Cosmetic Results and Patient Satisfaction Achieved With Skin Reducing Nipple Sparing Mastectomy of Ptotic Breast Followed by Delayed-immediate Submuscular Implant Based- Breast Reconstruction Surgery, and Comparing it to Submuscular Delayed- Immediate Implant- Based Breast Reconstruction Procedures After Skin- Sparing Mastectomy. Response-adaptive, Prospective Randomized Clinical Trial Recruiting NCT04345081
10 Results of Surgical Management According to the Type of Empirical Antibiotics in Acute Inflammatory Gallbladder Disease; a Randomized Controlled Trial Not yet recruiting NCT04321902

Search NIH Clinical Center for Lymphangitis

Cochrane evidence based reviews: lymphangitis

Genetic Tests for Lymphangitis

Anatomical Context for Lymphangitis

MalaCards organs/tissues related to Lymphangitis:

40
Breast, Lung, Skin, Lymph Node, Prostate, Testes, Colon

Publications for Lymphangitis

Articles related to Lymphangitis:

(show top 50) (show all 990)
# Title Authors PMID Year
1
Non-venereal sclerosing lymphangitis of the penis. 61
32516445 2020
2
Pulmonary manifestations of lymphoma: A pictorial essay. 61
32367851 2020
3
Signet ring cells in carcinomatous lymphangitis due to gastric adenocarcinoma. 61
32487420 2020
4
Association of metastatic pattern and molecular status in stage IV non-small cell lung cancer adenocarcinoma. 61
32323012 2020
5
Tubular acute lymphangitis caused by Rickettsia sibirica mongolitimonae. 61
32362407 2020
6
Acute lymphangitis. 61
32127433 2020
7
Complications of peripheral venous catheters: The need to propose an alternative route of administration. 61
31926285 2020
8
Salvage surgery for primary lung cancer complicated with Trousseau's syndrome after chemotherapy: a case report. 61
32206749 2020
9
Vascularized lymph node transfer with submental free flap. 61
31859077 2020
10
Efficacy of regorafenib in acute pulmonary carcinomatous lymphangitis as a manifestation of rectal cancer: A case report. 61
31807169 2019
11
Surgical Treatment of Advanced Lymphatic Filariasis of Lower Extremity Combining Vascularized Lymph Node Transfer and Excisional Procedures. 61
31038386 2019
12
Human Orf: An Under-recognized Entity. 61
31969245 2019
13
Microscopic features of small bowel mucosa of patients with Crohn's disease. 61
31888502 2019
14
Case report: palmar herpetic whitlow and forearm lymphangitis in a 10-year-old female. 61
31752766 2019
15
Lymphangitis associated with herpetic whitlow. 61
31785802 2019
16
Superficial allergic lymphangitis with a cutaneous recall reaction to a mosquito bite. 61
31400464 2019
17
Successful management of cutaneous lymphangitis carcinomatosa arising from cervical cancer with paclitaxel-cisplatin and bevacizumab combination therapy: a case report and review of the literature. 61
31699140 2019
18
Pulmonary lymphangitic carcinomatosis without concurrent liver metastasis from colon cancer detected using 18F-FDG PET/CT: A case report. 61
31593099 2019
19
[Ovarian cancer revealed by mammary skin metastases and cutaneous lymphangitis]. 61
31522828 2019
20
Platinum-doublet chemotherapy followed by pembrolizumab therapy for lung cancer with lymphangitis carcinomatosa mimicking interstitial pneumonitis: A case report. 61
31415404 2019
21
Brown recluse (L. rufescens) can bite in Northern Italy, too: first case report and review of the literature. 61
31401585 2019
22
Zosteriform lymphangitis carcinomatosis in the cervical area arising from pyriform fossa adenocarcinoma. 61
30520088 2019
23
Skin lesion and lymphangitis in an immunocompetent patient. 61
30792017 2019
24
Pulmonary lymphangitis carcinomatosis: systematic review and meta-analysis of case reports, 1970-2018. 61
30900501 2019
25
Efficacy of a collagen-fibrin sealant patch (TachoSil®) as adjuvant treatment in the inguinofemoral lymphadenectomy for vulvar cancer: a double-blind randomized-controlled trial. 61
30859297 2019
26
Fungicidal efficacy of photodynamic therapy using methylene blue against Sporothrix globosa in vitro and in vivo. 61
31106759 2019
27
Diagnosis and Management of Non-Purulent Cellulitis in the Emergency Department. 61
30892175 2019
28
Comparative pathophysiology and management of protein-losing enteropathy. 61
30762910 2019
29
Relationship between EGFR mutation and computed tomography characteristics of the lung in patients with lung adenocarcinoma. 61
30516345 2019
30
Slow-growing and Linearly Spreading Cutaneous Lesion: Often Misdiagnosed Mycobacterium Marinum Infection. 61
31058037 2019
31
An outbreak of tuberculosis in a middle school in Henan, China: Epidemiology and risk factors. 61
31730664 2019
32
Incidental finding of pulmonary lymphangitis carcinomatosa in a patient of chest trauma. 61
30745621 2019
33
[A Case of Type 4 Ascending Colon Cancer Showing Early Postoperative Lymphangitis Carcinomatosa]. 61
30765667 2019
34
The Place of Reductive Surgery in the Management of Gestational Ulcerative Gigantomastia: A Case Report at Sourô Sanou Teaching Hospital. 61
31236302 2019
35
CELLULITIS: A mnemonic to increase accuracy of cellulitis diagnosis. 61
30710907 2019
36
Penile Lymphangioma Secondary to Sclerosing Lymphangitis/Mondor's Disease in an HIV-Positive Patient. 61
31145067 2019
37
Lymphangiosis Carcinomatosa in a Patient with Giant Cutaneous SCC: Cervicopectoral Advancement Flap in Combination with Tunnel Transposition Flap from the Back as Promising Treatment Approach? 61
30607195 2018
38
Transcriptome analysis of Corynebacterium pseudotuberculosis biovar Equi in two conditions of the environmental stress. 61
30098432 2018
39
Bronchoalveolar carcinoma as an unsuspected cause for worsening shortness of breath in a patient with metastatic breast cancer. 61
30413446 2018
40
Cutaneous lymphangitic carcinomatosis: A rare metastasis from cervical cancer. 61
30128348 2018
41
A Prospective Evaluation of Health-Related Quality of Life following Lymphaticovenular Anastomosis for Upper and Lower Extremities Lymphedema. 61
29689576 2018
42
Pulmonary lymphangitic carcinomatosis with ground-glass opacities as presentation of prostate cancer. 61
29983983 2018
43
Local extensive granulomatous inflammation of the neck region and lymphangitis caused by Lichtheimia corymbifera infection in a Japanese Black calf. 61
30046515 2018
44
Nonvenereal Sclerosing Lymphangitis of the Penis: Importance of the Clinical Diagnosis. 61
29598993 2018
45
Lung Parenchymal and Endobronchial Metastases From Ovarian Carcinoma. 61
29944589 2018
46
Obstructive Lymphangitis Precedes Colitis in Murine Norovirus-Infected Stat1-Deficient Mice. 61
29753791 2018
47
Streptococcus equi subspecies zooepidemicus septicemia in alpacas: three cases and review of the literature. 61
29717639 2018
48
Pediatric lateral neck infections - Computed tomography vs ultrasound on initial evaluation. 61
29728170 2018
49
Nodular Lymphangitis (Sporotrichoid Lymphocutaneous Infections). Clues to Differential Diagnosis. 61
29747448 2018
50
Cutaneous lymphangitis carcinomatosa made cervicofacial oedema intractable in a patient with superior vena cava syndrome. 61
29674402 2018

Variations for Lymphangitis

Expression for Lymphangitis

Search GEO for disease gene expression data for Lymphangitis.

Pathways for Lymphangitis

GO Terms for Lymphangitis

Cellular components related to Lymphangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.8 VEGFD VEGFC ALB

Biological processes related to Lymphangitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.91 VEGFD VEGFC TBCB PROX1 PDPN FLT4
2 angiogenesis GO:0001525 9.78 VEGFD VEGFC PECAM1 FLT4
3 positive regulation of protein phosphorylation GO:0001934 9.71 VEGFD VEGFC PECAM1 FLT4
4 lung development GO:0030324 9.67 PROX1 PDPN NKX2-1
5 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.63 VEGFD VEGFC FLT4
6 platelet degranulation GO:0002576 9.56 VEGFD VEGFC PECAM1 ALB
7 induction of positive chemotaxis GO:0050930 9.52 VEGFD VEGFC
8 lymph vessel development GO:0001945 9.51 PROX1 FLT4
9 sprouting angiogenesis GO:0002040 9.5 VEGFD VEGFC FLT4
10 positive regulation of mast cell chemotaxis GO:0060754 9.43 VEGFD VEGFC
11 vascular endothelial growth factor signaling pathway GO:0038084 9.33 VEGFD VEGFC FLT4
12 positive regulation of endothelial cell proliferation GO:0001938 9.26 VEGFD VEGFC PROX1 FLT4
13 lymphangiogenesis GO:0001946 8.8 PROX1 PDPN FLT4

Molecular functions related to Lymphangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.03 VEGFD VEGFC TBCB SIGLEC5 PROX1 PECAM1
2 vascular endothelial growth factor receptor binding GO:0005172 8.96 VEGFD VEGFC
3 vascular endothelial growth factor receptor 3 binding GO:0043185 8.62 VEGFD VEGFC

Sources for Lymphangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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