Lymphatic Malformation 7 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

HFASD MCID: LYM150 MIFTS: 40	Lymphatic Malformation 7 (HFASD) Categories: Cancer diseases, Cardiovascular diseases, Fetal diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Neuronal diseases, Oral diseases, Rare diseases, Reproductive diseases
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Lymphatic Malformation 7

MalaCards integrated aliases for Lymphatic Malformation 7:

Name: Lymphatic Malformation 7 ⁵⁸

Hfasd ⁵⁸ ⁷⁶

Hydrops Fetalis, Nonimmune, and/or Atrial Septal Defect, Susceptibility to ⁶

Hydrops Fetalis, Nonimmune, and/or Atrial Septal Defect; Hfasd ⁵⁸

Hydrops Fetalis, Non-Immune, and/or Atrial Septal Defect ⁷⁶

Hydrops Fetalis, Nonimmune, and/or Atrial Septal Defect ⁵⁸

Central Conduction Lymphatic Anomaly ⁵⁸

Hydrops Fetalis ⁴⁵

Lmphm7 ⁵⁸

Characteristics:

OMIM:

⁵⁸

Inheritance:
autosomal dominant

Miscellaneous:
variable expressivity
variable severity
variability in age of onset (prenatal to adolescence)
onset of hydrops fetalis in utero
hydrops fetalis is associated with high morbidity and mortality in the neonatal period
hydrops resolves spontaneously with time after the neonatal period

HPO:

³³

lymphatic malformation 7:
Onset and clinical course variable expressivity
Inheritance autosomal dominant inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases Fetal diseases Rare diseases Cancer diseases
Anatomical: Immune diseases Cardiovascular diseases Neuronal diseases Reproductive diseases Oral diseases Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁸ 617300

MeSH ⁴⁵ D015160

MedGen ⁴³ C4310629 CN239945

SNOMED-CT via HPO ⁷⁰ 128060009 12856003 165397008 more

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Summaries for Lymphatic Malformation 7

UniProtKB/Swiss-Prot : ⁷⁶ Hydrops fetalis, non-immune, and/or atrial septal defect: A form of non-immune hydrops fetalis, a condition characterized by fluid accumulation in at least 2 fetal compartments, including abdominal cavities, pleura, and pericardium, or in body tissue. The majority of hydrops fetalis cases are non-immune conditions that present with generalized edema of the fetus. Approximately 15% of non- immune cases result from a lymphatic abnormality. HFASD is an autosomal dominant, lymphatic-related form with variable expressivity. Some patients suffer from severe manifestations that can result in early death, whereas others have milder clinical features, such as atrial septal defect or varicose veins as adults. The hydrops and/or swelling improves spontaneously in those who survive the neonatal period.

MalaCards based summary : Lymphatic Malformation 7, also known as hfasd, is related to hydrops fetalis and hydrops fetalis, nonimmune. An important gene associated with Lymphatic Malformation 7 is EPHB4 (EPH Receptor B4). Affiliated tissues include lung, heart and placenta, and related phenotypes are anemia and atrial septal defect

OMIM : ⁵⁸ LMPHM7 is an autosomal dominant disorder with variable expressivity. Some patients may develop severe nonimmune lymphatic-related hydrops fetalis (LRHF) in utero, resulting in early death, whereas others may have milder manifestations, such as atrial septal defect (ASD) or varicose veins as adults. The hydrops and/or swelling improves spontaneously in those who survive the neonatal period (summary by Martin-Almedina et al., 2016). (617300)

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Related Diseases for Lymphatic Malformation 7

Diseases in the Lymphatic Malformations family:

Lymphatic Malformation 1	Lymphatic Malformation 5
Lymphatic Malformation 2	Lymphatic Malformation 3
Lymphatic Malformation 4	Lymphatic Malformation 6
Lymphatic Malformation 7

Diseases related to Lymphatic Malformation 7 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 206)

#	Related Disease	Score
1	hydrops fetalis	13.0
2	hydrops fetalis, nonimmune	13.0
3	immune hydrops fetalis	12.7
4	hydrops fetalis, nonimmune, with gracile bones and dysmorphic features	12.3
5	hydrops fetalis anemia immune disorder absent thumb	12.3
6	fetal edema	12.0
7	mucopolysaccharidosis, type vii	11.8
8	hemoglobin h disease	11.7
9	alpha-thalassemia	11.6
10	teratoma	11.6
11	pyruvate kinase deficiency of red cells	11.6
12	gaucher disease, perinatal lethal	11.6
13	transaldolase deficiency	11.6
14	achondrogenesis, type ii	11.4
15	chondrodysplasia, blomstrand type	11.4
16	lymphatic malformation 6	11.4
17	semmekrot haraldsson weemaes syndrome	11.3
18	dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema	11.2
19	greenberg dysplasia	11.2
20	porphyria, congenital erythropoietic	11.2
21	pyknoachondrogenesis	11.2
22	retinohepatoendocrinologic syndrome	11.2
23	short-rib thoracic dysplasia 12	11.2
24	megalencephaly-capillary malformation-polymicrogyria syndrome	11.2
25	hypochondrogenesis	11.2
26	fetal erythroblastosis	11.2
27	fetal parvovirus syndrome	11.2
28	glucosephosphate isomerase deficiency	11.2
29	thalassemia	10.7
30	chorioangioma	10.5
31	down syndrome	10.4
32	cystic lymphangioma	10.4
33	atrial standstill 1	10.4
34	polyhydramnios	10.3
35	pulmonary sequestration	10.3
36	lymphangiectasia, pulmonary, congenital	10.3
37	chylothorax, congenital	10.3
38	diamond-blackfan anemia	10.3
39	hemophagocytic lymphohistiocytosis	10.3
40	lymphedema	10.3
41	thrombosis	10.3
42	gaucher's disease	10.3
43	syphilis	10.3
44	hemangioendothelioma	10.3
45	cytomegalovirus infection	10.3
46	autism	10.3
47	neuroblastoma	10.2
48	hemangioma	10.2
49	congenital dyserythropoietic anemia	10.2
50	congenital syphilis	10.2

Graphical network of the top 20 diseases related to Lymphatic Malformation 7:

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Symptoms & Phenotypes for Lymphatic Malformation 7

Human phenotypes related to Lymphatic Malformation 7:

³³ (show all 8)

#	Description	HPO Frequency	HPO Source Accession
1	anemia ³³	occasional (7.5%)	HP:0001903
2	atrial septal defect ³³	occasional (7.5%)	HP:0001631
3	respiratory distress ³³		HP:0002098
4	varicose veins ³³		HP:0002619
5	pericardial effusion ³³		HP:0001698
6	facial edema ³³		HP:0000282
7	pulmonary edema ³³		HP:0100598
8	nonimmune hydrops fetalis ³³		HP:0001790

Symptoms via clinical synopsis from OMIM:

⁵⁸

Muscle Soft Tissue:
edema
lymphedema

Abdomen External Features:
abdominal distention

Respiratory Lung:
pulmonary edema
pleural effusions
abnormal large lymphatic structures seen on lung biopsy
abnormal retrograde pulmonary lymphatic perfusion of right lung seen on magnetic resonance lymphangiography
proliferation of lymphatic channels in the lungs

Cardiovascular Heart:
pericardial effusions
atrial septal defect (in some patients)

Prenatal Manifestations Amniotic Fluid:
hydrops fetalis, nonimmune

Cardiovascular Vascular:
prominent veins in lower limbs
varicose veins (in older patients)
venous stasis
superficial clots in lower limbs

Abdomen:
retrograde flow of contrast in lymphatics into retroperitoneum and abdomen
proliferation of lymphatic channels in retroperitoneum
retroperitoneal masses

Skeletal Spine:
proliferation of lymphatic channels around the spine

Respiratory:
respiratory distress
chylothoraces
hydrothoraces

Head And Neck Face:
facial edema

Hematology:
anemia (in some patients)

Prenatal Manifestations:
nuchal translucency

Head And Neck Neck:
retrograde flow of contrast in lymphatics into neck

Chest:
retrograde flow of contrast in lymphatics into mediastinum
dilated and tortuous thoracic duct
lymphatic valves appear absent or dysfunctional

Abdomen Gastrointestinal:
diarrhea with fat-rich foods (in some patients)

Skin Nails Hair Skin Histology:
markedly increased dermal vascular structures

Clinical features from OMIM:

617300

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Drugs & Therapeutics for Lymphatic Malformation 7

Search Clinical Trials , NIH Clinical Center for Lymphatic Malformation 7

Cochrane evidence based reviews: hydrops fetalis

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Genetic Tests for Lymphatic Malformation 7

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Anatomical Context for Lymphatic Malformation 7

MalaCards organs/tissues related to Lymphatic Malformation 7:

⁴²

Lung, Heart, Placenta, Brain, Testes, Kidney, Bone

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Publications for Lymphatic Malformation 7

Articles related to Lymphatic Malformation 7:

(show top 50) (show all 847)

#	Title	Authors	Year
1	Placental chorioangioma associated with polyhydramnios and hydrops fetalis. ( 30700468 )	Willis C...Soydemir F	2019
2	Fetal-onset congenital dyserythropoietic anemia type 1 due to CDAN1 mutations presenting as hydrops fetalis. ( 30786798 )	Liu S...Li DZ	2019
3	Trisomy 21 and hydrops fetalis: parvovirus B19 or transient abnormal myelopoiesis? ( 30634881 )	Tan LN...Kilby MD	2019
4	Biallelic loss of function variants in ATP1A2 cause hydrops fetalis, microcephaly, arthrogryposis and extensive cortical malformations. ( 30690204 )	Monteiro FP...Kok F	2019
5	Non-immune hydrops fetalis neonate born to a mother with yellow nail syndrome. ( 30883972 )	Yamamoto H...Ihara K	2019
6	Outcomes following antenatal identification of hydrops fetalis: a single-centre experience from 2001 to 2012. ( 29769237 )	Gilby D.M....Manley B.J.	2018
7	A case of vasculopathy of unknown etiology associated with fatal hydrops fetalis and review of the literature on intimomedial mucoid degeneration. ( 29414431 )	Zaleski M.P....Millington K.	2018
8	Improved diagnosis in nonimmune hydrops fetalis using a standardized algorithm. ( 29500832 )	Laterre M....Sznajer Y.	2018
9	Thymic teratoma presenting as non-immune hydrops fetalis. ( 29515979 )	Hamza A....Higgins M.J.	2018
10	Mesalazine as a cause of fetal anemia and hydrops fetalis: A case report: Erratum. ( 29480868 )		2018
11	Nonimmune Hydrops Fetalis: Factors Which Predict Outcome. ( 29895999 )	Kumar M....Singh A.	2018
12	Recurring mutations in <i>RPL15</i> are linked to hydrops fetalis and treatment independence in Diamond-Blackfan anemia. ( 29599205 )	Wlodarski M.W....MacInnes A.W.	2018
13	Iron overload in transfusion-dependent survivors of hemoglobin Bart's hydrops fetalis. ( 29371322 )	Amid A....Kirby-Allen M.	2018
14	Characterization of Hb Bart's Hydrops Fetalis Caused by -a88-<sup>SEA</sup> and a Large Novel I+<sup>0</sup>-Thalassemia Deletion. ( 29493331 )	He S....Chen B.	2018
15	Biochemical and molecular analyses of infantile sialic acid storage disease in a patient with nonimmune hydrops fetalis. ( 29654786 )	Kang E....Lee B.H.	2018
16	Perinatal Lethal Gaucher Disease due to RecNcil Recombinant Mutation in the <i>GBA</i> Gene Presenting with Hydrops Fetalis and Severe Congenital Anemia. ( 29854527 )	Bhutada E....Matsika A.	2018
17	A case of mirror syndrome caused by hydrops fetalis after fetoscopic laser photocoagulation. ( 29881553 )	Kino E....Sameshima H.	2018
18	Sonographic Demonstration of Intracranial Hemorrhage in a Fetus with Hydrops Fetalis due to Rh Alloimmunization after Intrauterine Intravascular Transfusion: A Case Report and Review of the Literature. ( 29780649 )	Melekoglu R....Kural H.	2018
19	Invasive prenatal diagnosis of I+-thalassemia to control Hb Bart's hydrops fetalis syndrome: 15A years of experience. ( 29948167 )	Lai K....Chen P.	2018
20	Outcomes and morbidities of patients who survive haemoglobin Bart's hydrops fetalis syndrome: 20-year retrospective review. ( 29632273 )	Chan W.Y....Ha S.Y.	2018
21	Effect of maternal betamethasone on hydrops fetalis caused by extralobar pulmonary sequestration: a case report. ( 29553854 )	Guenot C....Vial Y.	2018
22	Metabolic causes of nonimmune hydrops fetalis: A next-generation sequencing panel as a first-line investigation. ( 29476731 )	SudriAc-Arnaud B....Bekri S.	2018
23	Potential new approaches to the management of the Hb Bart's hydrops fetalis syndrome: the most severe form of α-thalassemia. ( 30504332 )	King AJ...Higgs DR	2018
24	Depression, Anxiety, and Hyperactivity in Youth with HFASD: A Replication and Extension of Symptom Level Differences in Self-Report Versus Parent Report. ( 30357643 )	Taylor JM...Smerbeck A	2018
25	Hemochromatosis associated with cholelithiasis as a cause of hydrops fetalis and stillbirth: Prenatal diagnosis. ( 30378124 )	Darouich S...Masmoudi A	2018
26	Placental Chorioangioma with Nonimmune Hydrops Fetalis. ( 30075468 )	Merry-Sperry AD...Werthammer J	2018
27	A recessive truncating variant in thrombospondin-1 domain containing protein 1 gene THSD1 is the underlying cause of nonimmune hydrops fetalis, congenital cardiac defects, and haemangiomas in four patients from a consanguineous family. ( 30055085 )	Abdelrahman HA...Al-Gazali L	2018
28	hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia. ( 30115739 )	Mackie DI...Caron KM	2018
29	Hydrops Fetalis And The Parvovirus B-19. ( 30124157 )	Kontomanolis EN...Fasoulakis Z	2018
30	Peripheral Blood Smear of Bart's Hydrops Fetalis. ( 30127576 )	Aiempanakit K...Apinantriyo B	2018
31	Identification of novel PIEZO1 variants using prenatal exome sequencing and correlation to ultrasound and autopsy findings of recurrent hydrops fetalis. ( 30244526 )	Datkhaeva I...Janzen C	2018
32	Nonimmune hydrops fetalis: identifying the underlying genetic etiology. ( 30410095 )	Sparks TN...University of California Fetal?Maternal Consortium (UCfC)	2018
33	A Rare Hb H Hydrops Fetalis Syndrome Caused by the - -SEA Deletion in Combination with the Rare Hb Hirosaki Mutation in a Chinese Patient. ( 30486690 )	Li Q...Li L	2018
34	Deletion of macro domain containing 2(MACRO D2) associated with transient hydrops fetalis. ( 30545550 )	Uzun ?ilingir I...Varol F	2018
35	Novel mutation in CCBE 1 as a cause of recurrent hydrops fetalis from Hennekam lymphangiectasia-lymphedema syndrome-1. ( 30564329 )	Melber DJ...Lamale-Smith LM	2018
36	Fetal Thoracoamniotic Shunting in a Case of Congenital Pulmonary Airway Malformations with Hydrops Fetalis. ( 28948063 )	Nitta H....Aoki Y.	2017
37	Interstitial deletion of chromosome 1 (1p21.1p12) in an infant with congenital diaphragmatic hernia, hydrops fetalis, and interrupted aortic arch. ( 28174644 )	Ibrahim M....Tan K.	2017
38	Fetal hemoglobin Bart's hydrops fetalis: pathophysiology, prenatal diagnosis and possibility of intrauterine treatment. ( 28277912 )	Jatavan P....Tongsong T.	2017
39	Inborn errors of metabolism in a cohort of pregnancies with non-immune hydrops fetalis: a single center experience. ( 28822227 )	Bruwer Z....Al-Thihli K.	2017
40	A 6-year-old girl diagnosed with mevalonate kinase deficiency who had hydrops fetalis and neonatal-onset cholestasis. ( 28603204 )	Yamashita Y....Inui A.	2017
41	Genetic origin of I+(0)-thalassemia (SEA deletion) in Southeast Asian populations and application to accurate prenatal diagnosis of Hb Bart's hydrops fetalis syndrome. ( 28381876 )	Jomoui W....Fucharoen S.	2017
42	Alpha-Thalassemia Major and Restrictive Foramen Ovale in a Preterm Neonate Without Severe Hydrops Fetalis. ( 28381365 )	Hsu S.Y....Fu R.H.	2017
43	Nonimmune hydrops fetalis due to autosomal recessive hereditary spherocytosis. ( 29594000 )	Hannah D.M....Taboada C.D.	2017
44	Prognostic factors of hydrops fetalis with pleural effusion. ( 28672054 )	Nakayama A....Hayakawa M.	2017
45	Pulmonary Neuroendocrine Cell Hyperplasia in Hemoglobin Bart-induced Hydrops Fetalis: A model for Chronic Intrauterine Hypoxia. ( 28727978 )	Taweevisit M....Thorner P.S.	2017
46	Compound heterozygous GATA5 mutations in a girl with hydrops fetalis, congenital heart defects and genital anomalies. ( 28180938 )	Hempel M....Lessel D.	2017
47	Fetal Anemia Causing Hydrops Fetalis From an Alpha-Globin Variant: Homozygous Hemoglobin Constant Spring. ( 29240037 )	Komvilaisak P....Fucharoen G.	2017
48	An international registry of survivors with Hb Bart's Hydrops Fetalis Syndrome. ( 28057638 )	Songdej D....Higgs D.R.	2017
49	Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter? ( 29076544 )	Berger V.K....Gonzalez J.M.	2017
50	Mesalazine as a cause of fetal anemia and hydrops fetalis: A case report. ( 29390381 )	Ek S....Rosenborg S.	2017

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Genes for Lymphatic Malformation 7

Genes related to Lymphatic Malformation 7 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	EPHB4	EPH Receptor B4	Protein Coding	1200	Molecular basis known ⁵⁸ Pathogenic ⁶ Causative variation ⁷⁶	27400125 29905864

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Variations for Lymphatic Malformation 7

UniProtKB/Swiss-Prot genetic disease variations for Lymphatic Malformation 7:

⁷⁶

#	Symbol	AA change	Variation ID	SNP ID
1	EPHB4	p.Arg739Gln	VAR_078063	rs105751926
2	EPHB4	p.Ile782Ser	VAR_078064	rs105751926

ClinVar genetic disease variations for Lymphatic Malformation 7:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	EPHB4	NM_004444.4(EPHB4): c.2216G> A (p.Arg739Gln)	single nucleotide variant	Pathogenic	rs1057519263	GRCh38	Chromosome 7, 100807483: 100807483
2	EPHB4	NM_004444.4(EPHB4): c.2216G> A (p.Arg739Gln)	single nucleotide variant	Pathogenic	rs1057519263	GRCh37	Chromosome 7, 100405105: 100405105
3	EPHB4	NM_004444.4(EPHB4): c.2345T> G (p.Ile782Ser)	single nucleotide variant	Pathogenic	rs1057519264	GRCh38	Chromosome 7, 100806559: 100806559
4	EPHB4	NM_004444.4(EPHB4): c.2345T> G (p.Ile782Ser)	single nucleotide variant	Pathogenic	rs1057519264	GRCh37	Chromosome 7, 100404181: 100404181
5	EPHB4	NM_004444.5(EPHB4): c.2334+1G> C	single nucleotide variant	Pathogenic		GRCh38	Chromosome 7, 100807364: 100807364
6	EPHB4	NM_004444.5(EPHB4): c.2334+1G> C	single nucleotide variant	Pathogenic		GRCh37	Chromosome 7, 100404986: 100404986

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Expression for Lymphatic Malformation 7

Search GEO for disease gene expression data for Lymphatic Malformation 7.

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Pathways for Lymphatic Malformation 7

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GO Terms for Lymphatic Malformation 7

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Sources for Lymphatic Malformation 7

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia

Lymphatic Malformation 7 (HFASD)

Aliases & Classifications for Lymphatic Malformation 7

MalaCards integrated aliases for Lymphatic Malformation 7:

Characteristics:

OMIM:

HPO:

Classifications:

External Ids:

Summaries for Lymphatic Malformation 7

Related Diseases for Lymphatic Malformation 7

Diseases in the Lymphatic Malformations family:

Diseases related to Lymphatic Malformation 7 via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Lymphatic Malformation 7:

Symptoms & Phenotypes for Lymphatic Malformation 7

Human phenotypes related to Lymphatic Malformation 7:

Symptoms via clinical synopsis from OMIM:

Clinical features from OMIM:

Drugs & Therapeutics for Lymphatic Malformation 7

Cochrane evidence based reviews: hydrops fetalis

Genetic Tests for Lymphatic Malformation 7

Anatomical Context for Lymphatic Malformation 7

MalaCards organs/tissues related to Lymphatic Malformation 7:

Publications for Lymphatic Malformation 7

Articles related to Lymphatic Malformation 7:

Genes for Lymphatic Malformation 7

Genes related to Lymphatic Malformation 7 (1 elite genes):

Variations for Lymphatic Malformation 7

UniProtKB/Swiss-Prot genetic disease variations for Lymphatic Malformation 7:

ClinVar genetic disease variations for Lymphatic Malformation 7:

Expression for Lymphatic Malformation 7

Pathways for Lymphatic Malformation 7

GO Terms for Lymphatic Malformation 7

Sources for Lymphatic Malformation 7