Lymphatic Malformation 7 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

LMPHM7 MCID: LYM150 MIFTS: 43	Lymphatic Malformation 7 (LMPHM7) Categories: Cardiovascular diseases, Fetal diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Respiratory diseases, Skin diseases
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Aliases & Classifications for Lymphatic Malformation 7

MalaCards integrated aliases for Lymphatic Malformation 7:

Name: Lymphatic Malformation 7 ⁵⁷ ⁷²

Hydrops Fetalis, Nonimmune, and/or Atrial Septal Defect, Susceptibility to ²⁹ ⁶

Central Conduction Lymphatic Anomaly ⁵⁷ ⁷²

Hydrops Fetalis ⁴⁴ ⁷⁰

Lmphm7 ⁵⁷ ⁷²

Hfasd ⁵⁷ ⁷²

Hydrops Fetalis, Nonimmune, and/or Atrial Septal Defect; Hfasd ⁵⁷

Hydrops Fetalis, Non-Immune, and/or Atrial Septal Defect ⁷²

Hydrops Fetalis, Nonimmune, and/or Atrial Septal Defect ⁵⁷

Lymphatic Malformation, Type 7 ³⁹

Characteristics:

OMIM®:

⁵⁷ (Updated 20-May-2021)

Miscellaneous:
variable expressivity
variable severity
variability in age of onset (prenatal to adolescence)
onset of hydrops fetalis in utero
hydrops fetalis is associated with high morbidity and mortality in the neonatal period
hydrops resolves spontaneously with time after the neonatal period

Inheritance:
autosomal dominant

HPO:

³¹

lymphatic malformation 7:
Inheritance autosomal dominant inheritance
Onset and clinical course variable expressivity

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Fetal diseases
Anatomical: Neuronal diseases Cardiovascular diseases Reproductive diseases Skin diseases Immune diseases Gastrointestinal diseases Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM® ⁵⁷ 617300

OMIM Phenotypic Series ⁵⁷ PS153100

MeSH ⁴⁴ D015160

MedGen ⁴¹ C4310629 CN239945

UMLS ⁷⁰ C0020305

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Summaries for Lymphatic Malformation 7

UniProtKB/Swiss-Prot : ⁷² Lymphatic malformation 7: A form of primary lymphedema, a disease characterized by swelling of body parts due to developmental anomalies and functional defects of the lymphatic system. Patients with lymphedema may suffer from recurrent local infections. LMPHM7 is an autosomal dominant form with variable expressivity. Some individuals present with severe non-immune hydrops fetalis, which may cause perinatal demise or fully resolve after the neonatal period. Others present with no edema and have milder clinical features, such as atrial septal defect or varicose veins as adults.

MalaCards based summary : Lymphatic Malformation 7, also known as hydrops fetalis, nonimmune, and/or atrial septal defect, susceptibility to, is related to hydrops fetalis, nonimmune and immune hydrops fetalis, and has symptoms including edema and peau d'orange. An important gene associated with Lymphatic Malformation 7 is EPHB4 (EPH Receptor B4). The drug Anti-Arrhythmia Agents has been mentioned in the context of this disorder. Affiliated tissues include heart, placenta and brain, and related phenotypes are anemia and atrial septal defect

OMIM® : ⁵⁷ LMPHM7 is an autosomal dominant disorder with variable expressivity. Some patients may develop severe nonimmune lymphatic-related hydrops fetalis (LRHF) in utero, resulting in early death, whereas others may have milder manifestations, such as atrial septal defect (ASD) or varicose veins as adults. The hydrops and/or swelling improves spontaneously in those who survive the neonatal period (summary by Martin-Almedina et al., 2016). For a discussion of genetic heterogeneity of lymphatic malformation, see 153100. (617300) (Updated 20-May-2021)

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Related Diseases for Lymphatic Malformation 7

Diseases in the Rare Lymphatic Malformation family:

Lymphatic Malformation 1	Lymphatic Malformation 5
Lymphatic Malformation 2	Lymphatic Malformation 3
Lymphatic Malformation 4	Lymphatic Malformation 6
Lymphatic Malformation 7	Lymphatic Malformation 8
Lymphatic Malformation 9

Diseases related to Lymphatic Malformation 7 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 442)

#	Related Disease	Score
1	hydrops fetalis, nonimmune	12.2
2	immune hydrops fetalis	11.5
3	mucopolysaccharidosis, type vii	11.5
4	alpha-thalassemia	11.4
5	lymphatic malformation 8	11.4
6	ephb4-related lymphatic-related hydrops fetalis	11.4
7	piezo1-related generalized lymphatic dysplasia with non-immune hydrops fetalis	11.4
8	congenital disorder of glycosylation, type ia	11.3
9	hemoglobin h disease	11.3
10	lymphatic malformation 6	11.3
11	transaldolase deficiency	11.3
12	achondrogenesis, type ii	11.3
13	chondrodysplasia, blomstrand type	11.3
14	greenberg dysplasia	11.3
15	hypochondrogenesis	11.3
16	hydrops fetalis, nonimmune, with gracile bones and dysmorphism	11.2
17	gaucher's disease	11.2
18	galactosialidosis	11.2
19	glycoproteinosis	11.2
20	congenital dyserythropoietic anemia	11.2
21	free sialic acid storage disorders	11.2
22	multiple pterygium syndrome, escobar variant	11.1
23	hennekam syndrome	11.1
24	lymphangiectasia, pulmonary, congenital	11.1
25	pyruvate kinase deficiency of red cells	11.1
26	gaucher disease, perinatal lethal	11.1
27	arterial calcification of infancy	11.1
28	achondrogenesis	11.1
29	dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema	11.1
30	short-rib thoracic dysplasia 12	11.1
31	porphyria, congenital erythropoietic	11.1
32	pyknoachondrogenesis	11.1
33	megalencephaly-capillary malformation-polymicrogyria syndrome	11.1
34	congenital disorder of glycosylation, type ih	11.1
35	fetal erythroblastosis	11.1
36	fetal parvovirus syndrome	11.1
37	dyserythropoietic anemia and thrombocytopenia	11.1
38	thalassemia	10.9
39	polyhydramnios	10.7
40	cystic lymphangioma	10.6
41	down syndrome	10.6
42	teratoma	10.6
43	deficiency anemia	10.6
44	chorioangioma	10.6
45	mucopolysaccharidosis-plus syndrome	10.6
46	chromosomal triplication	10.6
47	hemolytic anemia	10.5
48	lymphangiectasis	10.5
49	pre-eclampsia	10.5
50	lysosomal storage disease	10.5

Graphical network of the top 20 diseases related to Lymphatic Malformation 7:

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Symptoms & Phenotypes for Lymphatic Malformation 7

Human phenotypes related to Lymphatic Malformation 7:

³¹ (show all 10)

#	Description	HPO Frequency	HPO Source Accession
1	anemia ³¹	occasional (7.5%)	HP:0001903
2	atrial septal defect ³¹	occasional (7.5%)	HP:0001631
3	lymphedema ³¹		HP:0001004
4	varicose veins ³¹		HP:0002619
5	respiratory distress ³¹		HP:0002098
6	abdominal distention ³¹		HP:0003270
7	pericardial effusion ³¹		HP:0001698
8	facial edema ³¹		HP:0000282
9	nonimmune hydrops fetalis ³¹		HP:0001790
10	pulmonary edema ³¹		HP:0100598

Symptoms via clinical synopsis from OMIM®:

⁵⁷ (Updated 20-May-2021)

Muscle Soft Tissue:
lymphedema
edema

Abdomen External Features:
abdominal distention

Respiratory Lung:
pulmonary edema
pleural effusions
abnormal large lymphatic structures seen on lung biopsy
abnormal retrograde pulmonary lymphatic perfusion of right lung seen on magnetic resonance lymphangiography
proliferation of lymphatic channels in the lungs

Prenatal Manifestations:
hydrops fetalis, nonimmune
nuchal translucency

Head And Neck Neck:
retrograde flow of contrast in lymphatics into neck

Chest:
retrograde flow of contrast in lymphatics into mediastinum
dilated and tortuous thoracic duct
lymphatic valves appear absent or dysfunctional

Abdomen Gastrointestinal:
diarrhea with fat-rich foods (in some patients)

Skin Nails Hair Skin Histology:
markedly increased dermal vascular structures

Respiratory:
respiratory distress
chylothoraces
hydrothoraces

Head And Neck Face:
facial edema

Hematology:
anemia (in some patients)

Cardiovascular Heart:
pericardial effusions
atrial septal defect (in some patients)

Cardiovascular Vascular:
prominent veins in lower limbs
varicose veins (in older patients)
venous stasis
superficial clots in lower limbs

Abdomen:
retrograde flow of contrast in lymphatics into retroperitoneum and abdomen
proliferation of lymphatic channels in retroperitoneum
retroperitoneal masses

Skeletal Spine:
proliferation of lymphatic channels around the spine

Clinical features from OMIM®:

617300 (Updated 20-May-2021)

UMLS symptoms related to Lymphatic Malformation 7:

edema; peau d'orange

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Drugs & Therapeutics for Lymphatic Malformation 7

Drugs for Lymphatic Malformation 7 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#		Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1		Anti-Arrhythmia Agents

Interventional clinical trials:

#	Name	Status	NCT ID	Phase
1	A Single-Center, Non-Randomized Study of the Safety and Efficacy of In Utero Hematopoietic Stem Cell Transplantation for the Treatment of Fetuses With Alpha Thalassemia Major	Recruiting	NCT02986698	Phase 1
2	Precision Medical Research of Non-immune Fetal Hydrops (NIFH)-From Prenatal Diagnosis to Intrauterine Treatment	Unknown status	NCT02956564
3	Hydrops: Diagnosing & Redefining Outcomes With Precision Study	Recruiting	NCT03412760
4	FAST Trial Registry: Prospective Observational Cohort Study of Fetal Atrial Flutter & Supraventricular Tachycardia	Recruiting	NCT03376438
5	Fetal Electrophysiologic Abnormalities in High-risk Pregnancies Associated With Fetal Demise	Recruiting	NCT03775954
6	Whole Exome Sequencing and Whole Genome Sequencing for Non-immune Fetal/Neonatal Hydrops	Recruiting	NCT03911531
7	Multicentric Prospective Study to Screen Inborn Errors of Metabolism in Non-immune Hydrops Fetalis by Massively Parallel Sequencing	Not yet recruiting	NCT04308603
8	Amniotic Fluid Tandem Mass Spectrometry for Pregnancies Complicated by Nonimmune Hydrops and Severe Symmetrical Intrauterine Growth Restriction-A Multicenter Prospective Pilot Cohort Study	Terminated	NCT00143039

Search NIH Clinical Center for Lymphatic Malformation 7

Cochrane evidence based reviews: hydrops fetalis

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Genetic Tests for Lymphatic Malformation 7

Genetic tests related to Lymphatic Malformation 7:

#	Genetic test	Affiliating Genes
1	Hydrops Fetalis, Nonimmune, and/or Atrial Septal Defect, Susceptibility to ²⁹	EPHB4

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Anatomical Context for Lymphatic Malformation 7

MalaCards organs/tissues related to Lymphatic Malformation 7:

⁴⁰

Heart, Placenta, Brain, Lung, Bone, Bone Marrow, Kidney

Sources

Publications for Lymphatic Malformation 7

Articles related to Lymphatic Malformation 7:

(show top 50) (show all 2271)

#	Title	Authors	PMID	Year
1	EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis. ⁶ ⁶¹ ⁵⁷	Martin-Almedina S...Ostergaard P	27400125	2016
2	Pathogenic variant in EPHB4 results in central conducting lymphatic anomaly. ⁶ ⁵⁷	Li D...Hakonarson H	29905864	2018
3	Newborn with hydrops fetalis and a severe supraventricular arrhythmia. ⁶¹	Battistuz E...Risso FM	31434639	2021
4	Ultrasound Features of Fetal Anemia Lessons From Hemoglobin Bart Disease. ⁶¹	Thammavong K...Tongsong T	32815580	2021
5	Hydrops fetalis in PKD1L1-related heterotaxy: Report of two foetuses and expanding the phenotypic and molecular spectrum. ⁶¹	Correa ARE...Gupta N	33655537	2021
6	Neonatal hereditary spherocytosis caused by a de novo frameshift mutation of the SPTB gene characterized by hydrops fetalis: A case report. ⁶¹	Zhang Y...Zhang X	33761640	2021
7	Hydrops fetalis with isolated massive ascites in a preterm neonate with rhesus disease. ⁶¹	Nourkami-Tutdibi N...Meyer S	33738630	2021
8	Congenital Chylothorax and Hydrops Fetalis: A Novel Neonatal Presentation of RASA1 Mutation. ⁶¹	Gallipoli A...Sehgal A	33608416	2021
9	High diagnosis rate for nonimmune hydrops fetalis with prenatal clinical exome from the Hydrops-Yielding Diagnostic Results of Prenatal Sequencing (HYDROPS) Study. ⁶¹	Al-Kouatly HB...Berger SI	33686258	2021
10	Disentangling molecular and clinical stratification patterns in beta-galactosidase deficiency. ⁶¹	Tebani A...Bekri S	33737400	2021
11	Persistence of SARS-CoV-2 in the first trimester placenta leading to transplacental transmission and fetal demise from an asymptomatic mother. ⁶¹	Shende P...Modi D	33346816	2021
12	Novel compound heterozygous frameshift variants in WDR81 associated with congenital hydrocephalus 3 with brain anomalies: First Chinese prenatal case confirms WDR81 involvement. ⁶¹	Su J...Qin Z	33724704	2021
13	[Isolated fetal pericardial effusion follow-up: Should we worry?] ⁶¹	Hidalgo Sanz J...Ayerza Casas A	33781717	2021
14	Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal cardiomyopathy. ⁶¹	Lieberwirth JK...Abou Jamra R	33547425	2021
15	Mucopolysaccharidosis type VII as a cause of recurrent Non-Immune Hydrops Fetalis: The first Tunisian case confirmed by Next-Generation Sequencing. ⁶¹	Hizem S...Ben Jemaa L	33382994	2021
16	Manifestations of thrombospondin type-1 domain-containing protein 1 gene mutation in an extremely premature infant with nonimmune hydrops fetalis. ⁶¹	Al Rawi WN...Al Zidgali FM	33569873	2021
17	Neonatal Hydrops Simulation Model: A Technical Report. ⁶¹	Connors J...Rosen O	33786242	2021
18	The role of chromosomal microarray analysis among fetuses with normal karyotype and single system anomaly or nonspecific sonographic findings. ⁶¹	Hui AS...Leung TY	32981064	2021
19	Nonimmune hydrops fetalis management from the perspective of fetal cardiologists: A single tertiary center experience from Egypt. ⁶¹	Rakha S...Elmarsafawy H	33074198	2021
20	Staged Management of Congenital Chylothorax With Hydrops Fetalis: An Insight Into EXIT Related Procedures. ⁶¹	Tai HL...Lien R	33681104	2021
21	Outcomes of haemoglobin Bart's hydrops fetalis following intrauterine transfusion in Ontario, Canada. ⁶¹	Zhang HJ...Kirby-Allen M	32616558	2021
22	A systematic review of monogenic etiologies of nonimmune hydrops fetalis. ⁶¹	Quinn AM...Berger SI	33082562	2021
23	Postnatal IVIG treatment for persistent anaemia in neonate due to congenital parvovirus infection. ⁶¹	Janssen O...Lin J	33431449	2021
24	Outcome of 45,X fetuses with cystic hygroma: A systematic review. ⁶¹	Levy AT...Al-Kouatly HB	33026168	2021
25	Case report of neonatal ductus venosus atresia. ⁶¹	Baller SE...Fauchere JC	32925113	2021
26	Prenatal diagnosis of abdominal lymphatic malformations. ⁶¹	Liu YP...Chen CP	33494985	2021
27	Obstetrician patterns of steroid administration for the prenatal management of congenital pulmonary airway malformations. ⁶¹	Aziz KB...Jelin EB	33164951	2021
28	Human parvovirus B19: a review of clinical and epidemiological aspects in Brazil. ⁶¹	Cnc Garcia R...Leon LA	33438475	2021
29	Evaluation of Pulmonary Hypoplasia in Various Congenital Anomalies with a Comparison of Two Conventional Methods of Assessment: Radial Alveolar Count (RAC) and Lung Weight: Body Weight Ratio (LBW). ⁶¹	Cherian DM...D P	33432563	2021
30	Non-immune hydrops fetalis was rare in Sweden during 1997-2015, but cases were associated with complications and poor prognosis. ⁶¹	Whybra C...Gunnarsson R	32187745	2020
31	Prenatal and Postnatal Management of Intrauterine Pleural Effusions Associated with Nonimmune Hydrops Fetalis. ⁶¹	Comert HSY...Sarihan H	33321527	2020
32	Challenges in chronic transfusion for patients with thalassemia. ⁶¹	Lal A	33275743	2020
33	Comprehensive screening for coexisting heterozygous α0-thalassemia in hemoglobin E trait. ⁶¹	Polprasert C...Rojnuckarin P	32633642	2020
34	Prenatal Treatment of Congenital Cytomegalovirus With Valganciclovir: A Case Report. ⁶¹	DeNoble AE...Hughes BL	32198512	2020
35	Rare Case of Fetal Permanent Junctional Reciprocating Tachycardia Refractory to Prenatal Antiarrhythmic Therapy. ⁶¹	Narang K...Cetta F	33367217	2020
36	Identification and management of congenital parvovirus B19 infection. ⁶¹	Attwood LO...Hui L	32860469	2020
37	Prenatal delineation of a distinct lethal fetal syndrome caused by a homozygous truncating KIDINS220 variant. ⁶¹	El-Dessouky SH...Zaki MS	32909676	2020
38	Intrauterine Fetal Blood Transfusion (IUBT) for Rh Incompatibility - 12 Years' Experience from Pakistan. ⁶¹	Raashid Y...Majeed N	33222739	2020
39	Prenatal diagnosis and management of monozygotic twins discordant for severe fetal abnormalities. ⁶¹	Chen CP...Wang W	33218418	2020
40	Nonimmune Hydrops Fetalis - More Than Meets the Eye? ⁶¹	Kilby MD	33027567	2020
41	Hydrops fetalis associated with anti-CD36 antibodies in fetal and neonatal alloimmune thrombocytopenia: Possible underlying mechanism. ⁶¹	Wu Y...Fu Y	32720360	2020
42	Complete resolution of arrhythmia-induced hydrops fetalis in utero. ⁶¹	Narayanan M...Kauffman RP	33040036	2020
43	Exome Sequencing for Prenatal Diagnosis in Nonimmune Hydrops Fetalis. ⁶¹	Sparks TN...University of California, San Francisco Center for Maternal-Fetal Precision Medicine	33027564	2020
44	A retrospective clinical analysis of 20 cases of congenital lung masses. ⁶¹	Gilad N...Weissmann-Brenner A	33108914	2020
45	New Insights of Human Parvovirus B19 in Modulating Erythroid Progenitor Cell Differentiation. ⁶¹	Feng S...Zhao D	32412895	2020
46	Congenital Hemolytic Anemia Because of Glucose Phosphate Isomerase Deficiency: Identification of 2 Novel Missense Mutations in the GPI Gene. ⁶¹	See WQ...Ha SY	31415279	2020
47	Prevalence of Alpha(α)-Thalassemia in Southeast Asia (2010-2020): A Meta-Analysis Involving 83,674 Subjects. ⁶¹	Goh LPW...Lee PC	33050119	2020
48	A homozygous variant in growth and differentiation factor 2 (GDF2) may cause lymphatic dysplasia with hydrothorax and nonimmune hydrops fetalis. ⁶¹	Aukema SM...Kerstjens-Frederikse WS	32618121	2020
49	Intrapericardial teratoma presenting hydrops fetalis in a 29-week preterm infant. ⁶¹	Endo R...Yoshimoto S	32808373	2020
50	A prospective study on rapid exome sequencing as a diagnostic test for multiple congenital anomalies on fetal ultrasound. ⁶¹	Corsten-Janssen N...van Diemen CC	32627857	2020

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Genes for Lymphatic Malformation 7

Genes related to Lymphatic Malformation 7 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	EPHB4	EPH Receptor B4	Protein Coding	1341.57	Molecular basis known ⁵⁷ Pathogenic ⁶ Causative variation ⁷² Genetic Tests ²⁹ Likely pathogenic ⁶ GeneCards inferred via : Disorders Variants (show sections)	27400125

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Variations for Lymphatic Malformation 7

ClinVar genetic disease variations for Lymphatic Malformation 7:

⁶

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	EPHB4	NM_004444.5(EPHB4):c.2345T>G (p.Ile782Ser)	SNV	Pathogenic	374837	rs1057519264	GRCh37: 7:100404181-100404181 GRCh38: 7:100806559-100806559
2	EPHB4	NM_004444.5(EPHB4):c.2216G>A (p.Arg739Gln)	SNV	Pathogenic	374836	rs1057519263	GRCh37: 7:100405105-100405105 GRCh38: 7:100807483-100807483
3	EPHB4	NM_004444.5(EPHB4):c.2334+1G>C	SNV	Pathogenic	599047	rs1562967463	GRCh37: 7:100404986-100404986 GRCh38: 7:100807364-100807364
4	EPHB4	NM_004444.5(EPHB4):c.2858_2859CT[1] (p.Leu954fs)	Microsatellite	Likely pathogenic	692019	rs1584651110	GRCh37: 7:100401186-100401187 GRCh38: 7:100803564-100803565

UniProtKB/Swiss-Prot genetic disease variations for Lymphatic Malformation 7:

⁷²

#	Symbol	AA change	Variation ID	SNP ID
1	EPHB4	p.Arg739Gln	VAR_078063	rs105751926
2	EPHB4	p.Ile782Ser	VAR_078064	rs105751926

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Expression for Lymphatic Malformation 7

Search GEO for disease gene expression data for Lymphatic Malformation 7.

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Pathways for Lymphatic Malformation 7

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GO Terms for Lymphatic Malformation 7

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Sources for Lymphatic Malformation 7

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia

Lymphatic Malformation 7 (LMPHM7)

Aliases & Classifications for Lymphatic Malformation 7

MalaCards integrated aliases for Lymphatic Malformation 7:

Characteristics:

OMIM®:

HPO:

Classifications:

External Ids:

Summaries for Lymphatic Malformation 7

Related Diseases for Lymphatic Malformation 7

Diseases in the Rare Lymphatic Malformation family:

Diseases related to Lymphatic Malformation 7 via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Lymphatic Malformation 7:

Symptoms & Phenotypes for Lymphatic Malformation 7

Human phenotypes related to Lymphatic Malformation 7:

Symptoms via clinical synopsis from OMIM®:

Clinical features from OMIM®:

UMLS symptoms related to Lymphatic Malformation 7:

Drugs & Therapeutics for Lymphatic Malformation 7

Drugs for Lymphatic Malformation 7 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Cochrane evidence based reviews: hydrops fetalis

Genetic Tests for Lymphatic Malformation 7

Genetic tests related to Lymphatic Malformation 7:

Anatomical Context for Lymphatic Malformation 7

MalaCards organs/tissues related to Lymphatic Malformation 7:

Publications for Lymphatic Malformation 7

Articles related to Lymphatic Malformation 7:

Genes for Lymphatic Malformation 7

Genes related to Lymphatic Malformation 7 (1 elite genes):

Variations for Lymphatic Malformation 7

ClinVar genetic disease variations for Lymphatic Malformation 7:

UniProtKB/Swiss-Prot genetic disease variations for Lymphatic Malformation 7:

Expression for Lymphatic Malformation 7

Pathways for Lymphatic Malformation 7

GO Terms for Lymphatic Malformation 7

Sources for Lymphatic Malformation 7