MCID: LYM127
MIFTS: 45

Lymphatic Malformations

Categories: Rare diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Lymphatic Malformations

MalaCards integrated aliases for Lymphatic Malformations:

Name: Lymphatic Malformations 53
Lymphatic Malformation 29
Lymphangiomas 53
Lymphangioma 73

Classifications:



External Ids:

ICD10 33 D18.1

Summaries for Lymphatic Malformations

NIH Rare Diseases : 53 Lymphatic malformations or lymphangiomas are benign (non-cancerous) vascular lesions made of fluid-filled spaces (cysts) thought to occur due to abnormal development of the lymphatic system.  In general, lymphatic malformations are categorized into macrocystic, microcystic, or combined depending on the size of the cysts; they are also classified in superficial lesions known as lymphangioma circumscriptum, and more deep-seated lesions (cavernous lymphangioma and cystic hygroma). They are present at birth, although they may be discovered later in life. They are most commonly located in the neck and axilla, but they also occur in the mouth, arm, mediastinum, lung, leg, abdomen and viscera. Some may appear as a tiny blue or red spot while others are massive and affect an entire arm or leg.[8019 The signs and symptoms vary depending on the size and location of the mass; however, lymphangiomas can disfigure affected areas and disrupt the function of nearby organs or tissues. The exact underlying cause is unknown. Treatment options vary based on the signs and symptoms present in each person but may include surgery.

MalaCards based summary : Lymphatic Malformations, also known as lymphatic malformation, is related to lymphangioma and kaposiform hemangioendothelioma. An important gene associated with Lymphatic Malformations is FLT4 (Fms Related Tyrosine Kinase 4), and among its related pathways/superpathways are Cargo trafficking to the periciliary membrane and Signaling events mediated by VEGFR1 and VEGFR2. The drugs Dopamine and Risperidone have been mentioned in the context of this disorder. Affiliated tissues include thymus, lung and tongue, and related phenotypes are Decreased viability in esophageal squamous lineage and Decreased cell migration

Related Diseases for Lymphatic Malformations

Diseases related to Lymphatic Malformations via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 lymphangioma 29.9 FLT4 PROX1
2 kaposiform hemangioendothelioma 29.3 FLT4 PROX1
3 hemangioma 28.9 FLT4 PROX1
4 microcystic lymphatic malformation 12.5
5 diffuse lymphatic malformation 12.1
6 capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth 12.0
7 mixed cystic lymphatic malformation 12.0
8 cystic lymphangioma 11.3
9 klippel-trenaunay-weber syndrome 11.2
10 cervicitis 10.1
11 multicystic dysplastic kidney 10.0 PKD1 PKD2
12 polycystic kidney disease 3 with or without polycystic liver disease 10.0 PKD1 PKD2
13 mediastinitis 9.9
14 polycystic kidney disease 2 with or without polycystic liver disease 9.9 PKD1 PKD2
15 bardet-biedl syndrome 17 9.9 PKD1 PKD2
16 polycystic liver disease 1 with or without kidney cysts 9.9 PKD1 PKD2
17 polycystic kidney disease 1 with or without polycystic liver disease 9.9 PKD1 PKD2
18 endotheliitis 9.9
19 interstitial emphysema 9.9 FLT4 PROX1
20 lymphangiosarcoma 9.9 FLT4 PROX1
21 polycystic liver disease 9.9 PKD1 PKD2
22 hennekam syndrome 9.9 FLT4 PROX1
23 polycystic kidney disease 4 with or without polycystic liver disease 9.8 PKD1 PKD2
24 autosomal genetic disease 9.8 PKD1 PKD2
25 angiosarcoma 9.8 FLT4 PROX1
26 macroglossia 9.8
27 noonan syndrome 1 9.8
28 pseudo-turner syndrome 9.8
29 tuberous sclerosis 9.8 PIK3CA PKD1
30 cystic kidney disease 9.7 PKD1 PKD2
31 lymphedema 9.7 FLT4 PROX1
32 polycystic kidney disease 9.7 PKD1 PKD2
33 myofibroma 9.6
34 gorham's disease 9.6
35 sleep apnea 9.6
36 hobnail hemangioma 9.6
37 orbital cellulitis 9.6
38 lymphopenia 9.6
39 ichthyosis 9.6
40 peritonitis 9.6
41 congenital ichthyosiform erythroderma 9.6
42 appendicitis 9.6
43 epilepsy 9.6
44 congenital fibrosarcoma 9.6
45 apnea, obstructive sleep 9.6
46 gigantism 9.6
47 dermoid cyst 9.6
48 hemangioendothelioma 9.6
49 transitional cell carcinoma 9.6
50 horseshoe kidney 9.6

Comorbidity relations with Lymphatic Malformations via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Lymphatic Malformations:



Diseases related to Lymphatic Malformations

Symptoms & Phenotypes for Lymphatic Malformations

GenomeRNAi Phenotypes related to Lymphatic Malformations according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.35 FLT4 PIK3CA PKD1 PKD2 PROX1
2 Decreased cell migration GR00055-A-1 9.33 PIK3CA PKD1 PKD2
3 Increased cell migration GR00055-A-3 8.8 PIK3CA PKD1 PKD2

MGI Mouse Phenotypes related to Lymphatic Malformations:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.72 PROX1 FLT4 PIK3CA PKD1 PKD2
2 adipose tissue MP:0005375 9.67 PROX1 FLT4 PIK3CA PKD1
3 digestive/alimentary MP:0005381 9.56 PROX1 FLT4 PKD1 PKD2
4 immune system MP:0005387 9.55 PROX1 FLT4 PIK3CA PKD1 PKD2
5 liver/biliary system MP:0005370 9.26 PROX1 FLT4 PKD1 PKD2
6 muscle MP:0005369 8.92 PROX1 FLT4 PIK3CA PKD1

Drugs & Therapeutics for Lymphatic Malformations

Drugs for Lymphatic Malformations (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 90)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
3
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
4 Picibanil Phase 4,Phase 2,Phase 3
5 Central Nervous System Depressants Phase 4
6 Central Nervous System Stimulants Phase 4
7 Serotonin Agents Phase 4
8 Serotonin Antagonists Phase 4
9 Neurotransmitter Agents Phase 4
10 Neurotransmitter Uptake Inhibitors Phase 4
11 Tranquilizing Agents Phase 4
12 Dopamine Agents Phase 4
13 Dopamine Antagonists Phase 4
14 Dopamine Uptake Inhibitors Phase 4
15 Antipsychotic Agents Phase 4
16 Psychotropic Drugs Phase 4
17
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
18
Tocopherol Approved, Investigational, Nutraceutical Phase 2, Phase 3 1406-66-2 14986
19
Vitamin E Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3 59-02-9 14985
20 Tocopherols Phase 2, Phase 3
21 Tocotrienols Phase 2, Phase 3
22 Vitamins Phase 2, Phase 3
23 Calcium, Dietary Phase 3,Phase 1,Phase 2
24 Tocotrienol Investigational, Nutraceutical Phase 2, Phase 3 6829-55-6
25 Omega 3 Fatty Acid Nutraceutical Phase 2, Phase 3
26
alemtuzumab Approved, Investigational Phase 2 216503-57-0
27
Fludarabine Approved Phase 2 21679-14-1, 75607-67-9 30751
28
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
29
Melphalan Approved Phase 2 148-82-3 4053 460612
30
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
31
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
32
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
33
Acetaminophen Approved Phase 1, Phase 2 103-90-2 1983
34
Everolimus Approved Phase 2 159351-69-6 6442177
35
Tacrolimus Approved, Investigational Phase 1, Phase 2 104987-11-3 445643 439492
36
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
37
Mycophenolate mofetil Approved, Investigational Phase 1, Phase 2 128794-94-5 5281078
38
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
39
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
40
Citric Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2,Phase 2 77-92-9 311
41 Sildenafil Citrate Phase 1, Phase 2,Phase 2 171599-83-0
42 Anesthetics Phase 1, Phase 2,Phase 2,Not Applicable
43 Vasodilator Agents Phase 1, Phase 2,Phase 2
44 Phosphodiesterase 5 Inhibitors Phase 1, Phase 2,Phase 2
45 Phosphodiesterase Inhibitors Phase 1, Phase 2,Phase 2
46 Alkylating Agents Phase 2
47 Gastrointestinal Agents Phase 2,Phase 1
48 Immunosuppressive Agents Phase 2,Phase 1
49 Antimetabolites Phase 2
50 Antimetabolites, Antineoplastic Phase 2

Interventional clinical trials:

(show top 50) (show all 52)
# Name Status NCT ID Phase Drugs
1 The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome Recruiting NCT00768820 Phase 4 methylphenidate, fluoxetin, risperidone
2 OK432 (Picibanil) in the Treatment of Lymphatic Malformations Active, not recruiting NCT03427619 Phase 4 OK432
3 Indicated Prevention With Long-chain Polyunsaturated Omega-3 Fatty Acids in Patients With 22q11 Microdeletion Syndrome. Unknown status NCT02070211 Phase 2, Phase 3
4 Study of Picibanil (OK432) Sclerotherapy in Children With Macrocystic Lymphatic Malformations Completed NCT00010452 Phase 2, Phase 3 picibanil
5 Effects of PTH Replacement on Bone in Hypoparathyroidism Completed NCT00395538 Phase 3 PTH 1-34
6 A Study to Evaluate Sildenafil for the Treatment of Lymphatic Malformations Completed NCT01290484 Phase 1, Phase 2 Sildenafil
7 Sildenafil for the Treatment of Lymphatic Malformations Recruiting NCT02335242 Phase 2 Sildenafil 20 mg tablets
8 Trial of Taselisib in Overgrowth Recruiting NCT03290092 Phase 1, Phase 2 Taselisib (GDC0032);Taselisib (GDC0032)
9 Octreotide VS Placebo in Prevention of Salivary Fistulae After Post Radiation Salvage Surgery Recruiting NCT02437825 Phase 2 octreotide
10 Immune Disorder HSCT Protocol Recruiting NCT01821781 Phase 2 Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan
11 Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies Active, not recruiting NCT00975819 Phase 2 sirolimus
12 Phase I/II Thymus Transplantation With Immunosuppression #950 Active, not recruiting NCT00579527 Phase 1, Phase 2 Rabbit anti-thymocyte globulin;Cyclosporine;Tacrolimus;Methylprednisolone or Prednisolone;Daclizumab;Mycophenolate mofetil
13 Thymus Transplantation Dose in DiGeorge #932 Active, not recruiting NCT00576836 Phase 2
14 Thymus Transplantation in DiGeorge Syndrome #668 Active, not recruiting NCT00576407 Phase 2
15 Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic Malformations Not yet recruiting NCT03243019 Phase 2 rapamycin
16 Metyrosine (Demser®) for the Treatment of Psychotic Disorders in Patients With Velocardiofacial Syndrome Terminated NCT01127503 Phase 2 Metyrosine;Placebo
17 Phase I Drug Trial for S/E of Marimastat in Disabling Malformations When no Other Options. Completed NCT00261391 Phase 1 Marimastat
18 Safety and Efficacy Study of NFC-1 in Subjects Aged 12-17 Years With 22q11.2DS & Associated Neuropsychiatric Conditions Completed NCT02895906 Phase 1 NFC-1
19 Thymus Transplantation With Immunosuppression Active, not recruiting NCT00579709 Phase 1
20 Parathyroid and Thymus Transplantation in DiGeorge #931 Active, not recruiting NCT00566488 Phase 1
21 Selenium in the Treatment of Complicated Lymphatic Malformations Terminated NCT01212965 Phase 1 Selenium
22 Serum-Free Thymus Transplantation in DiGeorge Anomaly Terminated NCT00849888 Phase 1
23 Expanded Noninvasive Genomic Medical Assessment: The Enigma Study Unknown status NCT02787486
24 Non-Invasive Chromosomal Evaluation of 22q11.2 Unknown status NCT02541058
25 Whole Blood Specimen Collection From Pregnant Subjects Unknown status NCT02430584
26 Genetic Modifiers for 22q11.2 Syndrome Unknown status NCT00916955
27 Genetics and Psychopathology in the 22q11 Deletion Syndrome Unknown status NCT00161109
28 Immunologic Evaluation in Patients With DiGeorge Syndrome or Velocardiofacial Syndrome Unknown status NCT00005102
29 Imaging of Lymphatic Anomalies Completed NCT02744027 Not Applicable
30 Diagnosis of Hemangiomas and Vascular Malformations Completed NCT00577213
31 Perception of Facial Emotions in Schizophrenia and 22q11 Deletion Syndrome Completed NCT02634671 Not Applicable
32 Resolution of Primary Immune Defect in 22q11.2 Deletion Syndrome Completed NCT02460328
33 Cognitive Remediation in 22q11DS Completed NCT01781923 Not Applicable
34 Computerized Cognitive Skills Training for Adolescents With Velocardiofacial Syndrome Completed NCT00917189 Not Applicable
35 Middle and Inner Ear Malformation in Children With Velocardiofacial Syndrome Completed NCT00784173
36 Velocardiofacial (VCFS; 22q11.2; DiGeorge) Syndrome Study Completed NCT00105274
37 Study of Phenotype and Genotype Correlations in Patients With Contiguous Gene Deletion Syndromes Completed NCT00004351
38 Lymphatic Anomalies Registry Recruiting NCT02399527
39 Development of a Specific Scale of Life'Quality for Children With Low-flow Vascular Malformations Recruiting NCT03440827 Not Applicable
40 AVAST Anomalies Vasculaires Associées au Syndrome de Turner (Vascular Abnormalities Associated With Turner Syndrome) Recruiting NCT02250456
41 Registry for Vascular Anomalies Associated With Coagulopathy Recruiting NCT00576888
42 First Trimester Screening for Trisomy 21, 18, 13 and 22q11.2 Deletion Syndrome Recruiting NCT03375359
43 Social Cognition Training and Cognitive Remediation Recruiting NCT03284060 Not Applicable
44 SNP-based Microdeletion and Aneuploidy RegisTry (SMART) Recruiting NCT02381457
45 Airway Vascular Lesions Active, not recruiting NCT00866827
46 Lymphatic Function in Patients With a Fontan-Kreutzer Circulation Active, not recruiting NCT03379805
47 Examining Genetic Factors That Affect the Severity of 22q11.2 Deletion Syndrome Active, not recruiting NCT00556530
48 Thymus Transplantation Safety-Efficacy Available NCT01220531 Rabbit anti-thymocyte globulin;Cyclosporine;Tacrolimus;Methylprednisolone or Prednisolone;Basiliximab;Mycophenolate mofetil
49 Imaging Lymphatic Function in Normal Subjects and in Persons With Lymphatic Disorders Enrolling by invitation NCT00833599 NIRFLI with ICG
50 Prenatal Examination of Deletion 22q11 Syndrome : Thymic Dysgenesis THYMI Study Enrolling by invitation NCT02890472

Search NIH Clinical Center for Lymphatic Malformations

Genetic Tests for Lymphatic Malformations

Genetic tests related to Lymphatic Malformations:

# Genetic test Affiliating Genes
1 Lymphatic Malformation 29

Anatomical Context for Lymphatic Malformations

MalaCards organs/tissues related to Lymphatic Malformations:

41
Thymus, Lung, Tongue, Bone, Whole Blood, Skin, Endothelial

Publications for Lymphatic Malformations

Articles related to Lymphatic Malformations:

(show top 50) (show all 207)
# Title Authors Year
1
A Novel Presentation of Littoral Cell Angioma and Lymphatic Malformations in a Neonate. ( 29610184 )
2018
2
New Frontiers in Our Understanding of Lymphatic Malformations of the Head and Neck: Natural History and Basic Research. ( 29217059 )
2018
3
Thirty-day perioperative outcomes in resection of cervical lymphatic malformations. ( 29447887 )
2018
4
Multidisciplinary Approach to the Management of Lymphatic Malformations of the Head and Neck. ( 29217060 )
2018
5
Sirolimus as treatment for 19 patients with refractory cervicofacial lymphatic malformation. ( 28782106 )
2018
6
Lymphographic-Like Technique for the Treatment of Microcystic Lymphatic Malformation Components of <3 mm. ( 29191875 )
2018
7
Treatment of giant cervico-mediastinal lymphatic malformations: a caseA series. ( 29903033 )
2018
8
Combined capillary-venous-lymphatic malformations without overgrowth in patients with Klippel-TrAcnaunay syndrome. ( 29233587 )
2018
9
Abdominal lymphatic malformations. ( 29796772 )
2018
10
Use of percutaneous bleomycin sclerotherapy for orbital lymphatic malformations. ( 29902086 )
2018
11
Treatment of Lymphatic Malformations with the mTOR Inhibitor Sirolimus: A Systematic Review. ( 29924669 )
2018
12
Intraneural microcystic lymphatic malformation of the ulnar nerve at the Guyon canal: Unusual cause of ulnar pain in a child. ( 28342818 )
2017
13
Spontaneously Resolved Macrocystic Lymphatic Malformations: Predictive Variables and Outcomes. ( 29026809 )
2017
14
Fetal Lymphatic Malformations: More Variable Than We Think? ( 28127788 )
2017
15
National Characteristics of Lymphatic Malformations in Children: Inpatient Estimates and Trends in the United States, 2000 to 2009. ( 29293192 )
2017
16
Diagnosis and surgical treatment of cervical macrocystic lymphatic malformations in infants. ( 28810590 )
2017
17
Role of intralesional bleomycin sclerotherapy as the sole or adjunct treatment of superficial ocular adnexal lymphatic malformations. ( 28776595 )
2017
18
Long-Term Follow-Up of Lymphatic Malformations in Children Treated with Sildenafil. ( 28884903 )
2017
19
Down-regulation of polycystin in lymphatic malformations: possible role in the proliferation of lymphatic endothelial cells. ( 28552828 )
2017
20
Microcystic Lymphatic Malformation Successfully Treated With Topical Rapamycin. ( 28557723 )
2017
21
Multistage Sclerotherapy for Extensive Lymphatic Malformations With Airway Involvement in Infant: A Protocol to Prevent Tracheotomy. ( 28390757 )
2017
22
VIPAR, a quantitative approach to 3D histopathology applied to lymphatic malformations. ( 28814672 )
2017
23
Efficacy and safety of oral sildenafil in treatment of pediatric head and neck lymphatic malformations. ( 28093934 )
2017
24
Percutaneous ultrasound-guided sclerotherapy with polidocanol microfoam for lymphatic malformations. ( 28818226 )
2017
25
Prenatal growth characteristics of lymphatic malformations. ( 27836363 )
2017
26
Efficacy of Topical Sirolimus (Rapamycin) for the Treatment of Microcystic Lymphatic Malformations. ( 27784048 )
2017
27
Anatomic distribution of cervicofacial lymphatic malformations based on lymph node groups. ( 28483255 )
2017
28
Retrograde Lymph Flow Leads to Chylothorax in Transgenic Mice with Lymphatic Malformations. ( 28683257 )
2017
29
Single center experience with intralesional bleomycin sclerotherapy for lymphatic malformations. ( 28779454 )
2017
30
Percutaneous sclerotherapy of pediatric lymphatic malformations: experience and outcomes according to the agent used. ( 28606692 )
2017
31
Intralesional Endoscopy and Septectomy as a Diagnostic Tool and Treatment Method for Lymphatic Malformations. ( 29038775 )
2017
32
Surgical excision is the treatment of choice for cervical lymphatic malformations with mediastinal expansion. ( 29173777 )
2017
33
New Navigation Surgery for Resection of Lymphatic Malformations Using Indocyanine Green Fluorescence Imaging. ( 28500279 )
2017
34
The Public Health Burden of Lymphatic Malformations in Children: National Estimates in the United States, 2000-2009. ( 28759318 )
2017
35
Using sildenafil (viagra) to treat congenital lymphatic malformations of the head and neck, our experience. ( 28390608 )
2017
36
Somatic KRAS mutation in an infant with linear nevus sebaceous syndrome associated with lymphatic malformations: A case report and literature review. ( 29381910 )
2017
37
A large retroperitoneal lymphatic malformation successfully treated with traditional Japanese Kampo medicine in combination with surgery. ( 28718090 )
2017
38
Real-time MRI-guided percutaneous sclerotherapy of low-flow head and neck lymphatic malformations in the pediatric population - a stepwise approach. ( 28213627 )
2017
39
Oral sildenafil as a treatment option for lymphatic malformations in PIK3CA-related tissue overgrowth syndromes. ( 27502552 )
2016
40
Imaging Appearance of Lymphatic Malformations. ( 27657191 )
2016
41
Treatment of deep-seated facial microcystic lymphatic malformations with intralesional injection of pingyangmycin. ( 27631231 )
2016
42
Pediatric lymphatic malformations: evolving understanding and therapeutic options. ( 26815877 )
2016
43
Surgical Excision With Bleomycin Irrigation: A Better Primary Treatment Choice for Pediatric Submandibular Lymphatic Malformations. ( 27789267 )
2016
44
Recurrent Orbital Inflammation Mimicking Orbital Cellulitis Associated With Orbitopalpebral Venous Lymphatic Malformation. ( 27879620 )
2016
45
Lymphatic Malformation in Newborns as the First Sign of Diffuse Lymphangiomatosis: Successful Treatment with Sirolimus. ( 26506225 )
2016
46
Intraabdominal Lymphatic Malformations: Pearls and Pitfalls of Diagnosis and Differential Diagnoses in Pediatric Patients. ( 28004970 )
2016
47
TLR4 preconditioning is associated with low success of OK-432 treatment for lymphatic malformations in children. ( 26801484 )
2016
48
Surgical Treatment Outcomes of Head and Neck Lymphatic Malformations in Patients With a Variety of Ages and Unusual Sites. ( 27046466 )
2016
49
Guidelines and parameters: percutaneous sclerotherapy for the treatment of head and neck venous and lymphatic malformations. ( 26801946 )
2016
50
Update on orbital lymphatic malformations. ( 27219273 )
2016

Variations for Lymphatic Malformations

Expression for Lymphatic Malformations

Search GEO for disease gene expression data for Lymphatic Malformations.

Pathways for Lymphatic Malformations

GO Terms for Lymphatic Malformations

Cellular components related to Lymphatic Malformations according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 motile cilium GO:0031514 9.16 PKD1 PKD2
2 ciliary membrane GO:0060170 8.96 PKD1 PKD2
3 polycystin complex GO:0002133 8.62 PKD1 PKD2

Biological processes related to Lymphatic Malformations according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.59 FLT4 PIK3CA
2 positive regulation of endothelial cell proliferation GO:0001938 9.58 FLT4 PROX1
3 positive regulation of endothelial cell migration GO:0010595 9.58 FLT4 PROX1
4 kidney development GO:0001822 9.58 PKD1 PKD2 PROX1
5 spinal cord development GO:0021510 9.57 PKD1 PKD2
6 JAK-STAT cascade GO:0007259 9.56 PKD1 PKD2
7 vasculature development GO:0001944 9.55 FLT4 PIK3CA
8 embryonic placenta development GO:0001892 9.54 PKD1 PKD2
9 renal system development GO:0072001 9.52 PKD1 PKD2
10 detection of mechanical stimulus GO:0050982 9.51 PKD1 PKD2
11 placenta blood vessel development GO:0060674 9.49 PKD1 PKD2
12 lymph vessel development GO:0001945 9.48 FLT4 PROX1
13 lymphangiogenesis GO:0001946 9.46 FLT4 PROX1
14 cytoplasmic sequestering of transcription factor GO:0042994 9.43 PKD1 PKD2
15 mesonephric tubule development GO:0072164 9.37 PKD1 PKD2
16 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031659 9.32 PKD1 PKD2
17 mesonephric duct development GO:0072177 9.26 PKD1 PKD2
18 metanephric ascending thin limb development GO:0072218 9.16 PKD1 PKD2
19 neural tube development GO:0021915 9.13 PKD1 PKD2 PROX1
20 liver development GO:0001889 8.92 PIK3CA PKD1 PKD2 PROX1

Molecular functions related to Lymphatic Malformations according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel binding GO:0044325 8.96 PKD1 PKD2
2 calcium channel activity GO:0005262 8.62 PKD1 PKD2

Sources for Lymphatic Malformations

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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