MCID: LYM127
MIFTS: 50

Lymphatic Malformations

Categories: Cancer diseases, Cardiovascular diseases, Fetal diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Neuronal diseases, Oral diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Lymphatic Malformations

MalaCards integrated aliases for Lymphatic Malformations:

Name: Lymphatic Malformations 54
Lymphatic Malformation 30
Lymphangiomas 54
Lymphangioma 74

Classifications:



External Ids:

ICD10 34 D18.1
UMLS 74 C0024221

Summaries for Lymphatic Malformations

NIH Rare Diseases : 54 Lymphatic malformations or lymphangiomas are benign (non-cancerous) vascular lesions made of fluid-filled spaces (cysts) thought to occur due to abnormal development of the lymphatic system.  In general, lymphatic malformations are categorized into macrocystic, microcystic, or combined depending on the size of the cysts; they are also classified in superficial lesions known as lymphangioma circumscriptum, and more deep-seated lesions (cavernous lymphangioma and cystic hygroma). They are present at birth, although they may be discovered later in life. They are most commonly located in the neck and axilla, but they also occur in the mouth, arm, mediastinum, lung, leg, abdomen and viscera. Some may appear as a tiny blue or red spot while others are massive and affect an entire arm or leg. The signs and symptoms vary depending on the size and location of the mass; however, lymphangiomas can disfigure affected areas and disrupt the function of nearby organs or tissues. The exact underlying cause is unknown. Treatment options vary based on the signs and symptoms present in each person but may include surgery.

MalaCards based summary : Lymphatic Malformations, also known as lymphatic malformation, is related to lymphangioma and lymphangiosarcoma. An important gene associated with Lymphatic Malformations is PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha), and among its related pathways/superpathways are Cargo trafficking to the periciliary membrane and Signaling events mediated by VEGFR1 and VEGFR2. The drugs Risperidone and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include thymus, lung and endothelial, and related phenotypes are Decreased viability in esophageal squamous lineage and Decreased cell migration

Related Diseases for Lymphatic Malformations

Diseases in the Lymphatic Malformations family:

Lymphatic Malformation 1 Lymphatic Malformation 5
Lymphatic Malformation 2 Lymphatic Malformation 3
Lymphatic Malformation 4 Lymphatic Malformation 6
Lymphatic Malformation 7

Diseases related to Lymphatic Malformations via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 227)
# Related Disease Score Top Affiliating Genes
1 lymphangioma 29.9 FLT4 PIK3CA PROX1
2 lymphangiosarcoma 29.7 FLT4 PROX1
3 angiosarcoma 29.6 FLT4 PROX1
4 hydrocele 29.6 FLT4 PKD2
5 cystic kidney disease 29.5 PKD1 PKD2
6 kaposiform hemangioendothelioma 29.5 FLT4 PROX1
7 alveoli adenoma 29.4 FLT4 PROX1
8 hemangioma 29.3 FLT4 PROX1
9 tuberous sclerosis 29.2 PIK3CA PKD1
10 microcystic lymphatic malformation 12.7
11 capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth 12.5
12 abdominal cystic lymphangioma 12.5
13 lymphatic malformation 2 12.4
14 lymphatic malformation 3 12.4
15 lymphatic malformation 6 12.4
16 capillary lymphangioma 12.3
17 cavernous lymphangioma 12.2
18 diffuse lymphatic malformation 12.2
19 colonic lymphangioma 12.2
20 lymphatic malformation 1 12.2
21 lymphatic malformation 5 12.2
22 lymphatic malformation 4 12.2
23 lymphatic malformation 7 12.2
24 mixed cystic lymphatic malformation 12.2
25 orbital lymphangioma 12.2
26 primary laryngeal lymphangioma 12.1
27 nuchal bleb, familial 12.0
28 cobb syndrome 11.5
29 cystic lymphangioma 11.4
30 klippel-trenaunay-weber syndrome 11.3
31 multiple enchondromatosis, maffucci type 11.1
32 infantile myofibromatosis 11.1
33 hygroma cervical 11.0
34 cavernous hemangioma 10.5
35 hemangioma-thrombocytopenia syndrome 10.4
36 retiform hemangioendothelioma 10.4
37 sarcoma 10.4
38 intussusception 10.3
39 kaposi sarcoma 10.3
40 intestinal obstruction 10.1
41 anogenital venereal wart 10.1
42 squamous cell carcinoma 10.1
43 lymphangiectasis 10.1
44 malignant hemangioma 10.1
45 multifocal lymphangioendotheliomatosis with thrombocytopenia 10.1
46 kaposiform lymphangiomatosis 10.1
47 lymphoma 10.1
48 human venous malformation 10.1
49 adenomatoid tumor 10.0
50 multicystic dysplastic kidney 10.0 PKD1 PKD2

Comorbidity relations with Lymphatic Malformations via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Lymphatic Malformations:



Diseases related to Lymphatic Malformations

Symptoms & Phenotypes for Lymphatic Malformations

GenomeRNAi Phenotypes related to Lymphatic Malformations according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.35 FLT4 PIK3CA PKD1 PKD2 PROX1
2 Decreased cell migration GR00055-A-1 9.33 PIK3CA PKD1 PKD2
3 Increased cell migration GR00055-A-3 8.8 PIK3CA PKD1 PKD2

MGI Mouse Phenotypes related to Lymphatic Malformations:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.72 FLT4 PIK3CA PKD1 PKD2 PROX1
2 adipose tissue MP:0005375 9.67 FLT4 PIK3CA PKD1 PROX1
3 digestive/alimentary MP:0005381 9.56 FLT4 PKD1 PKD2 PROX1
4 immune system MP:0005387 9.55 FLT4 PIK3CA PKD1 PKD2 PROX1
5 liver/biliary system MP:0005370 9.26 FLT4 PKD1 PKD2 PROX1
6 muscle MP:0005369 8.92 FLT4 PIK3CA PKD1 PROX1

Drugs & Therapeutics for Lymphatic Malformations

Drugs for Lymphatic Malformations (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 107)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
2
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
3
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
4 Picibanil Phase 4,Phase 2,Phase 3
5 Psychotropic Drugs Phase 4
6 Neurotransmitter Agents Phase 4,Phase 1,Phase 2
7 Serotonin Agents Phase 4
8 Serotonin Antagonists Phase 4
9 Dopamine Agents Phase 4
10 Neurotransmitter Uptake Inhibitors Phase 4
11 Central Nervous System Depressants Phase 4,Phase 1,Phase 2
12 Antipsychotic Agents Phase 4
13 Dopamine Uptake Inhibitors Phase 4
14 Central Nervous System Stimulants Phase 4
15 Dopamine Antagonists Phase 4
16 Tranquilizing Agents Phase 4
17
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
18
Tocopherol Approved, Investigational Phase 2, Phase 3 1406-66-2 14986
19
Mineral oil Approved, Vet_approved Phase 2, Phase 3 8042-47-5
20
Parathyroid hormone Approved, Investigational Phase 3,Phase 1,Phase 2 9002-64-6
21
Vitamin E Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3 59-02-9 14985
22
Calcium Approved, Nutraceutical Phase 3,Phase 1,Phase 2 7440-70-2 271
23 Tocotrienol Investigational Phase 2, Phase 3 6829-55-6
24 Omega 3 Fatty Acid Phase 2, Phase 3
25 Tocotrienols Phase 2, Phase 3
26 Tocopherols Phase 2, Phase 3
27 Vitamins Phase 2, Phase 3
28 Calcium, Dietary Phase 3,Phase 1,Phase 2
29
Octreotide Approved, Investigational Phase 2 83150-76-9 6400441 383414
30
Sodium Citrate Approved, Investigational Phase 1, Phase 2,Phase 2 68-04-2
31
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
32
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
33
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
34
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
35
alemtuzumab Approved, Investigational Phase 2 216503-57-0
36
Melphalan Approved Phase 2 148-82-3 460612 4053
37
Fludarabine Approved Phase 2 75607-67-9, 21679-14-1 30751
38
Histamine Approved, Investigational Phase 1, Phase 2 51-45-6 774
39
Promethazine Approved, Investigational Phase 1, Phase 2 60-87-7 4927
40
Acetaminophen Approved Phase 1, Phase 2 103-90-2 1983
41
Tacrolimus Approved, Investigational Phase 1, Phase 2 104987-11-3 445643 439492 6473866
42
Methylprednisolone hemisuccinate Approved Phase 1, Phase 2 2921-57-5
43
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
44
Diphenhydramine Approved, Investigational Phase 1, Phase 2 147-24-0, 58-73-1 3100
45
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
46
Prednisolone phosphate Approved, Vet_approved Phase 1, Phase 2 302-25-0
47
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
48
Citric Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2,Phase 2 77-92-9 311
49
Prednisolone hemisuccinate Experimental Phase 1, Phase 2 2920-86-7
50 Gastrointestinal Agents Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 54)
# Name Status NCT ID Phase Drugs
1 OK432 (Picibanil) in the Treatment of Lymphatic Malformations Completed NCT03427619 Phase 4 OK432
2 The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome Recruiting NCT00768820 Phase 4 methylphenidate, fluoxetin, risperidone
3 Indicated Prevention With Long-chain Polyunsaturated Omega-3 Fatty Acids in Patients With 22q11 Microdeletion Syndrome. Unknown status NCT02070211 Phase 2, Phase 3
4 Study of Picibanil (OK432) Sclerotherapy in Children With Macrocystic Lymphatic Malformations Completed NCT00010452 Phase 2, Phase 3 picibanil
5 Effects of PTH Replacement on Bone in Hypoparathyroidism Terminated NCT00395538 Phase 3 PTH 1-34
6 Octreotide VS Placebo in Prevention of Salivary Fistulae After Post Radiation Salvage Surgery Unknown status NCT02437825 Phase 2 octreotide
7 A Study to Evaluate Sildenafil for the Treatment of Lymphatic Malformations Completed NCT01290484 Phase 1, Phase 2 Sildenafil
8 Sildenafil for the Treatment of Lymphatic Malformations Recruiting NCT02335242 Phase 2 Sildenafil 20 mg tablets
9 Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic Malformations Recruiting NCT03243019 Phase 2 rapamycin
10 Trial of Taselisib in Overgrowth Recruiting NCT03290092 Phase 1, Phase 2 Taselisib (GDC0032);Taselisib (GDC0032)
11 Immune Disorder HSCT Protocol Recruiting NCT01821781 Phase 2 Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan
12 Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies Active, not recruiting NCT00975819 Phase 2 sirolimus
13 Phase I/II Thymus Transplantation With Immunosuppression #950 Active, not recruiting NCT00579527 Phase 1, Phase 2 Rabbit anti-thymocyte globulin;Cyclosporine;Tacrolimus;Methylprednisolone or Prednisolone;Daclizumab;Mycophenolate mofetil
14 Thymus Transplantation Dose in DiGeorge #932 Active, not recruiting NCT00576836 Phase 2
15 Thymus Transplantation in DiGeorge Syndrome #668 Active, not recruiting NCT00576407 Phase 2
16 Metyrosine (Demser®) for the Treatment of Psychotic Disorders in Patients With Velocardiofacial Syndrome Terminated NCT01127503 Phase 2 Metyrosine;Placebo
17 Phase I Drug Trial for S/E of Marimastat in Disabling Malformations When no Other Options. Completed NCT00261391 Phase 1 Marimastat
18 Safety and Efficacy Study of NFC-1 in Subjects Aged 12-17 Years With 22q11.2DS & Associated Neuropsychiatric Conditions Completed NCT02895906 Phase 1 NFC-1
19 Thymus Transplantation With Immunosuppression Active, not recruiting NCT00579709 Phase 1
20 Parathyroid and Thymus Transplantation in DiGeorge #931 Active, not recruiting NCT00566488 Phase 1
21 Selenium in the Treatment of Complicated Lymphatic Malformations Terminated NCT01212965 Phase 1 Selenium
22 Serum-Free Thymus Transplantation in DiGeorge Anomaly Terminated NCT00849888 Phase 1
23 Prenatal Examination of Deletion 22q11 Syndrome : Thymic Dysgenesis THYMI Study Unknown status NCT02890472
24 Non-Invasive Chromosomal Evaluation of 22q11.2 Unknown status NCT02541058
25 Genetic Modifiers for 22q11.2 Syndrome Unknown status NCT00916955
26 Genetics and Psychopathology in the 22q11 Deletion Syndrome Unknown status NCT00161109
27 Immunologic Evaluation in Patients With DiGeorge Syndrome or Velocardiofacial Syndrome Unknown status NCT00005102
28 Airway Vascular Lesions Completed NCT00866827
29 Imaging of Lymphatic Anomalies Completed NCT02744027 Not Applicable
30 Diagnosis of Hemangiomas and Vascular Malformations Completed NCT00577213
31 Expanded Noninvasive Genomic Medical Assessment: The Enigma Study Completed NCT02787486
32 Perception of Facial Emotions in Schizophrenia and 22q11 Deletion Syndrome Completed NCT02634671 Not Applicable
33 Resolution of Primary Immune Defect in 22q11.2 Deletion Syndrome Completed NCT02460328
34 Cognitive Remediation in 22q11DS Completed NCT01781923 Not Applicable
35 National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions Completed NCT01322165
36 Computerized Cognitive Skills Training for Adolescents With Velocardiofacial Syndrome Completed NCT00917189 Not Applicable
37 Middle and Inner Ear Malformation in Children With Velocardiofacial Syndrome Completed NCT00784173
38 Velocardiofacial (VCFS; 22q11.2; DiGeorge) Syndrome Study Completed NCT00105274
39 Study of Phenotype and Genotype Correlations in Patients With Contiguous Gene Deletion Syndromes Completed NCT00004351
40 Lymphatic Anomalies Registry Recruiting NCT02399527
41 Development of a Specific Scale of Life'Quality for Children With Low-flow Vascular Malformations Recruiting NCT03440827 Not Applicable
42 AVAST Anomalies Vasculaires Associées au Syndrome de Turner (Vascular Abnormalities Associated With Turner Syndrome) Recruiting NCT02250456
43 Registry for Vascular Anomalies Associated With Coagulopathy Recruiting NCT00576888
44 Pathogenetic Basis of Aortopathy and Aortic Valve Disease Recruiting NCT03440697
45 First Trimester Screening for Trisomy 21, 18, 13 and 22q11.2 Deletion Syndrome Recruiting NCT03375359
46 Social Cognition Training and Cognitive Remediation Recruiting NCT03284060 Not Applicable
47 Whole Blood Specimen Collection From Pregnant Subjects Recruiting NCT02430584
48 Lymphatic Function in Patients With a Fontan-Kreutzer Circulation Active, not recruiting NCT03379805
49 SNP-based Microdeletion and Aneuploidy RegisTry (SMART) Active, not recruiting NCT02381457
50 Examining Genetic Factors That Affect the Severity of 22q11.2 Deletion Syndrome Active, not recruiting NCT00556530

Search NIH Clinical Center for Lymphatic Malformations

Genetic Tests for Lymphatic Malformations

Genetic tests related to Lymphatic Malformations:

# Genetic test Affiliating Genes
1 Lymphatic Malformation 30

Anatomical Context for Lymphatic Malformations

MalaCards organs/tissues related to Lymphatic Malformations:

42
Thymus, Lung, Endothelial, Bone, Whole Blood, Tongue, Lymph Node

Publications for Lymphatic Malformations

Articles related to Lymphatic Malformations:

(show top 50) (show all 282)
# Title Authors Year
1
Symptom Resolution and Volumetric Reduction of Abdominal Lymphatic Malformations With Sclerotherapy. ( 30502256 )
2019
2
Cervical lymphatic malformations: Prenatal characteristics and ex-utero intrapartum treatment. ( 30707444 )
2019
3
Retropharyngeal lymphatic malformations: report of two successfully treated cases and review of the literature. ( 30745588 )
2019
4
Flow Pattern Classification in Lymphatic Malformations by Indocyanine Green Lymphography. ( 30817659 )
2019
5
Clinical application of molecular genetics in lymphatic malformations. ( 30847392 )
2019
6
Topical rapamycin in superficial lymphatic malformation: microcystic lymphatic malformation or verrucous venous malformation? ( 30710605 )
2019
7
Expression of Embryonic Stem Cell Markers in Microcystic Lymphatic Malformation. ( 30901291 )
2019
8
Liposuction-like Sclerotherapy Technique: a Deep Approach to Superficial Lymphatic Malformation. ( 30731174 )
2019
9
Indications for tracheostomy in children with head and neck lymphatic malformation: analysis of a nationwide survey in Japan. ( 30778735 )
2019
10
Guidelines (short version) of the French Society of Otorhinolaryngology (SFORL) on cervical lymphatic malformation in adults and children: Diagnosis. ( 30819600 )
2019
11
The Application of Virtual Reality for Preoperative Planning of Lymphovenous Anastomosis in a Patient with a Complex Lymphatic Malformation. ( 30884770 )
2019
12
A Novel Presentation of Littoral Cell Angioma and Lymphatic Malformations in a Neonate. ( 29610184 )
2018
13
New Frontiers in Our Understanding of Lymphatic Malformations of the Head and Neck: Natural History and Basic Research. ( 29217059 )
2018
14
Thirty-day perioperative outcomes in resection of cervical lymphatic malformations. ( 29447887 )
2018
15
Multidisciplinary Approach to the Management of Lymphatic Malformations of the Head and Neck. ( 29217060 )
2018
16
Treatment of giant cervico-mediastinal lymphatic malformations: a caseA series. ( 29903033 )
2018
17
Combined capillary-venous-lymphatic malformations without overgrowth in patients with Klippel-TrAcnaunay syndrome. ( 29233587 )
2018
18
Abdominal lymphatic malformations. ( 29796772 )
2018
19
Use of percutaneous bleomycin sclerotherapy for orbital lymphatic malformations. ( 29902086 )
2018
20
Treatment of Lymphatic Malformations with the mTOR Inhibitor Sirolimus: A Systematic Review. ( 29924669 )
2018
21
Epithelial-Myoepithelial Carcinoma Presenting as a Pseudo Veno-Lymphatic Malformation. ( 30080758 )
2018
22
Verrucous hemangioma (also known as verrucous venous malformation): A vascular anomaly frequently misdiagnosed as a lymphatic malformation. ( 30216519 )
2018
23
PIK3CA mutations are specifically localized to lymphatic endothelial cells of lymphatic malformations. ( 29985963 )
2018
24
A Genetic Approach to the Classification of Primary Lymphoedema and Lymphatic Malformations. ( 30055909 )
2018
25
Gene Expression Differences in Pediatric Lymphatic Malformations: Size Really Matters. ( 30130159 )
2018
26
The use of topical rapamycin in the treatment of superficial lymphatic malformations. ( 30296533 )
2018
27
Acquired lymphatic malformations of the buccal mucosa: A case report. ( 30349701 )
2018
28
Giant Lymphatic Malformations in Lower Extremity in an Adult: A Case Report. ( 30453789 )
2018
29
Image-Guided Percutaneous Bleomycin and Bevacizumab Sclerotherapy of Orbital Lymphatic Malformations in Children. ( 30488306 )
2018
30
Percutaneous Lauromacrogol Foam Sclerotherapy for the Treatment of Acute Airway Compression Caused by Lymphatic Malformations in Infants. ( 30498754 )
2018
31
Long-term health-related quality of life in children with lymphatic malformations treated with sclerotherapy generally matched age-appropriate standardised population norms. ( 30556934 )
2018
32
30-Day outcomes analysis of NSQIP-pediatric for surgical management of head and neck lymphatic malformations in children. ( 30578991 )
2018
33
A case of microcystic lymphatic malformation successfully treated with topical sirolimus. ( 30133999 )
2018
34
Topical rapamycin (sirolimus) for treatment of cutaneous microcystic lymphatic malformation of the gluteal area. ( 30530427 )
2018
35
Papillary thyroid cancer nodal metastases mimicking a slow-flow lymphatic malformation. ( 29982186 )
2018
36
Lower lip capillary malformation associated with lymphatic malformation without overgrowth: Part of the spectrum of CLAPO syndrome. ( 29766551 )
2018
37
Lymphatic malformation with acquired Horner syndrome in an infant. ( 29326377 )
2018
38
Right Paracardiac Cystic Lymphatic Malformation. ( 28733166 )
2018
39
Normalization of Congenital Venous Stasis Retinopathy Following Sclerotherapy of a Macrocystic Lymphatic Malformation. ( 28746255 )
2018
40
Current status, pitfalls and future directions in the diagnosis and therapy of lymphatic malformation. ( 28851128 )
2018
41
Linkage of Metabolic Defects to Activated PIK3CA Alleles in Endothelial Cells Derived from Lymphatic Malformation. ( 29346025 )
2018
42
An Omental Lymphatic Malformation Mimicking Ascites in a 2-Year-Old Boy. ( 29470295 )
2018
43
Treatment of mediastinal lymphatic malformation in children: an analysis of a nationwide survey in Japan. ( 29484494 )
2018
44
Net-like superficial lymphatic malformation: a new entity? ( 29736938 )
2018
45
Is multiple session of intralesional bleomycin mandatory for complete resolution of macrocystic lymphatic malformation? ( 29928081 )
2018
46
Isolated lymphatic malformation of the postcricoid space. ( 30138530 )
2018
47
Lymphatic malformation of the masseter: A case report. ( 30191108 )
2018
48
Sirolimus for the treatment of "verrucous" venous malformation: are we missing the lymphatic malformation component? ( 30240774 )
2018
49
Spontaneously Resolved Macrocystic Lymphatic Malformations: Predictive Variables and Outcomes. ( 29026809 )
2017
50
Fetal Lymphatic Malformations: More Variable Than We Think? ( 28127788 )
2017

Variations for Lymphatic Malformations

Expression for Lymphatic Malformations

Search GEO for disease gene expression data for Lymphatic Malformations.

Pathways for Lymphatic Malformations

GO Terms for Lymphatic Malformations

Cellular components related to Lymphatic Malformations according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ciliary membrane GO:0060170 8.96 PKD1 PKD2
2 polycystin complex GO:0002133 8.62 PKD1 PKD2

Biological processes related to Lymphatic Malformations according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of endothelial cell proliferation GO:0001938 9.58 FLT4 PROX1
2 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.58 FLT4 PIK3CA
3 positive regulation of endothelial cell migration GO:0010595 9.57 FLT4 PROX1
4 spinal cord development GO:0021510 9.56 PKD1 PKD2
5 JAK-STAT cascade GO:0007259 9.55 PKD1 PKD2
6 vasculature development GO:0001944 9.54 FLT4 PIK3CA
7 kidney development GO:0001822 9.54 PKD1 PKD2 PROX1
8 embryonic placenta development GO:0001892 9.52 PKD1 PKD2
9 renal system development GO:0072001 9.51 PKD1 PKD2
10 detection of mechanical stimulus GO:0050982 9.49 PKD1 PKD2
11 placenta blood vessel development GO:0060674 9.48 PKD1 PKD2
12 lymph vessel development GO:0001945 9.46 FLT4 PROX1
13 lymphangiogenesis GO:0001946 9.43 FLT4 PROX1
14 cytoplasmic sequestering of transcription factor GO:0042994 9.4 PKD1 PKD2
15 mesonephric tubule development GO:0072164 9.32 PKD1 PKD2
16 mesonephric duct development GO:0072177 9.26 PKD1 PKD2
17 metanephric ascending thin limb development GO:0072218 9.16 PKD1 PKD2
18 neural tube development GO:0021915 9.13 PKD1 PKD2 PROX1
19 liver development GO:0001889 8.92 PIK3CA PKD1 PKD2 PROX1

Molecular functions related to Lymphatic Malformations according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium channel activity GO:0005262 8.62 PKD1 PKD2

Sources for Lymphatic Malformations

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35 ICD10 via Orphanet
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