MCID: LYM023
MIFTS: 31

Lymphatic System Cancer

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Lymphatic System Cancer

MalaCards integrated aliases for Lymphatic System Cancer:

Name: Lymphatic System Cancer 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060073

Summaries for Lymphatic System Cancer

Disease Ontology : 12 An immune system cancer that is located in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue.

MalaCards based summary : Lymphatic System Cancer is related to lymph node cancer and lymphangiosarcoma. An important gene associated with Lymphatic System Cancer is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Immune response Fc epsilon RI pathway and NF-kappaB Signaling. The drugs Antibodies, Blocking and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include the lymphatic system, and related phenotypes are hematopoietic system and cellular

Related Diseases for Lymphatic System Cancer

Diseases related to Lymphatic System Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 lymph node cancer 11.1
2 lymphangiosarcoma 11.1
3 spleen cancer 11.1
4 nodular tenosynovitis 10.5 PTPRC SERPINA3
5 prostate lymphoma 10.4 CD5 SMUG1
6 dendritic cell thymoma 10.4 CD5 TTN
7 heart lymphoma 10.4 BCL6 PTPRC
8 brain sarcoma 10.4 PTPRC SMUG1
9 bone lymphoma 10.4 BCL6 SMUG1
10 splenic tuberculosis 10.4 IL2 SMUG1
11 pharynx squamous cell carcinoma 10.4 AKT1 SMUG1
12 intravascular large b-cell lymphoma 10.4 BCL6 CD5
13 primary cutaneous anaplastic large cell lymphoma 10.4 ALK NPM1 PTPRC
14 alk-positive anaplastic large cell lymphoma 10.4 ALK NPM1
15 histiocytoma 10.4 ALK PTPRC SERPINA3
16 extracutaneous mastocytoma 10.4 CD2 PTPRC
17 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.4 BCL6 PTPRC
18 testicular lymphoma 10.4 BCL6 PTPRC
19 liver inflammatory pseudotumor 10.3 PTPRC UCHL1
20 connective tissue cancer 10.3 AKT1 SERPINA3 SMUG1
21 lymphoblastic lymphoma 10.3 BCL6 CD5 PTPRC
22 hodgkin's lymphoma, mixed cellularity 10.3 PTPRC UCHL1
23 plasma protein metabolism disease 10.3 CD19 CD5 SERPINA3
24 lymphoplasmacyte-rich meningioma 10.3 CD79A UCHL1
25 marginal zone b-cell lymphoma 10.3 BCL6 CD5 CD79A
26 respiratory system cancer 10.3 AKT1 ALK SMUG1
27 cortical thymoma 10.3 CD2 TTN
28 sternum cancer 10.3 SMUG1 TNFRSF8
29 plasmacytoma 10.3 CD79A IL2 PTPRC
30 bladder lymphoma 10.3 CD19 CD5 CD79A
31 t-cell adult acute lymphocytic leukemia 10.3 CD2 CD5 IL2
32 lobomycosis 10.3 CD19 CD2
33 gallbladder small cell carcinoma 10.3 NCAM1 SMUG1
34 myasthenia gravis 10.2 IL2 MUSK TTN
35 lethal midline granuloma 10.2 CD2 NCAM1
36 t cell deficiency 10.2 CD2 IL2 PTPRC
37 myeloid sarcoma 10.2 NCAM1 NPM1 PTPRC
38 congenital hypogammaglobulinemia 10.2 CD19 CD79A
39 breast lymphoma 10.2 BCL6 CD5 CD79A SMUG1
40 thymus lipoma 10.2 CD5 PTPRC TNFRSF8
41 immune system organ benign neoplasm 10.2 CD5 PTPRC TNFRSF8
42 histiocytosis 10.2 PTPRC SERPINA3 TNFRSF8
43 autonomic nervous system neoplasm 10.2 AKT1 ALK NCAM1
44 composite lymphoma 10.2 BCL6 CD5
45 peripheral nervous system neoplasm 10.2 AKT1 ALK NCAM1
46 autoimmune disease of musculoskeletal system 10.2 CD19 IL2 MUSK
47 respiratory system disease 10.2 AKT1 ALK IL2 SMUG1
48 endometrial small cell carcinoma 10.2 NCAM1 PTPRC
49 gastric small cell carcinoma 10.2 NCAM1 PTPRC UCHL1
50 conventional fibrosarcoma 10.2 PTPRC TNFRSF8

Graphical network of the top 20 diseases related to Lymphatic System Cancer:



Diseases related to Lymphatic System Cancer

Symptoms & Phenotypes for Lymphatic System Cancer

MGI Mouse Phenotypes related to Lymphatic System Cancer:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.21 AKT1 BCL6 CD19 CD5 CD79A IL2
2 cellular MP:0005384 10.2 AKT1 BCL6 CD19 CD79A IL2 MUSK
3 immune system MP:0005387 10.15 AKT1 BCL6 CD19 CD5 CD79A IL2
4 homeostasis/metabolism MP:0005376 10.14 AKT1 ALK BCL6 CD19 CD79A IL2
5 mortality/aging MP:0010768 10.03 AKT1 ALK BCL6 CD19 IL2 MUSK
6 liver/biliary system MP:0005370 9.92 AKT1 BCL6 CD19 CD79A IL2 NPM1
7 neoplasm MP:0002006 9.81 AKT1 ALK CD19 CD79A IL2 NPM1
8 normal MP:0002873 9.56 AKT1 BCL6 CD19 CD2 CD5 CD79A
9 respiratory system MP:0005388 9.17 AKT1 ALK BCL6 IL2 MUSK PTPRC

Drugs & Therapeutics for Lymphatic System Cancer

Drugs for Lymphatic System Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies, Blocking
2 Immunoglobulins
3 Immunotoxins
4 Antibodies
5 Immunologic Factors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Collection of Human Samples to Study Hairy Cell and Other Leukemias, and to Develop Recombinant Immunotoxins for Cancer Treatment Recruiting NCT01087333

Search NIH Clinical Center for Lymphatic System Cancer

Genetic Tests for Lymphatic System Cancer

Anatomical Context for Lymphatic System Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Lymphatic System Cancer:

20
The Lymphatic System

Publications for Lymphatic System Cancer

Variations for Lymphatic System Cancer

Expression for Lymphatic System Cancer

Search GEO for disease gene expression data for Lymphatic System Cancer.

Pathways for Lymphatic System Cancer

GO Terms for Lymphatic System Cancer

Cellular components related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.93 AKT1 ALK CD19 CD2 CD5 CD79A
2 integral component of plasma membrane GO:0005887 9.5 ALK CD19 CD2 CD5 MUSK PTPRC
3 external side of plasma membrane GO:0009897 9.1 CD19 CD2 CD5 CD79A NCAM1 PTPRC

Biological processes related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.65 CD2 CD79A PTPRC
2 B cell differentiation GO:0030183 9.54 BCL6 CD79A PTPRC
3 positive regulation of regulatory T cell differentiation GO:0045591 9.46 BCL6 IL2
4 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.43 SPN TNFRSF8
5 positive regulation of isotype switching to IgG isotypes GO:0048304 9.4 IL2 PTPRC
6 positive regulation of protein phosphorylation GO:0001934 9.33 AKT1 IL2 MUSK
7 negative regulation of B cell apoptotic process GO:0002903 9.32 BCL6 IL2
8 cellular defense response GO:0006968 9.26 SH2D1A SPN
9 positive regulation of B cell proliferation GO:0030890 9.13 BCL6 IL2 PTPRC
10 negative regulation of apoptotic process GO:0043066 8.92 AKT1 BCL6 IL2 NPM1

Molecular functions related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 AKT1 ALK BCL6 CD19 CD2 CD5
2 transmembrane signaling receptor activity GO:0004888 8.92 CD5 CD79A SPN TNFRSF8

Sources for Lymphatic System Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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