Lymphatic System Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lymphatic System Cancer

MalaCards integrated aliases for Lymphatic System Cancer:

Name: Lymphatic System Cancer ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060073

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Summaries for Lymphatic System Cancer

Disease Ontology : ¹² An immune system cancer that is located in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue.

MalaCards based summary : Lymphatic System Cancer is related to lymph node cancer and lymphangiosarcoma. An important gene associated with Lymphatic System Cancer is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Innate Immune System and Immune response Fc epsilon RI pathway. The drugs Antibodies, Blocking and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and lung, and related phenotypes are hematopoietic system and homeostasis/metabolism

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Related Diseases for Lymphatic System Cancer

Diseases related to Lymphatic System Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)

#	Related Disease	Score	Top Affiliating Genes
1	lymph node cancer	11.1
2	lymphangiosarcoma	11.1
3	spleen cancer	11.1
4	nodular tenosynovitis	10.5	PTPRC SERPINA3
5	dendritic cell thymoma	10.4	CD5 TTN
6	primary cutaneous anaplastic large cell lymphoma	10.4	ALK NPM1 PTPRC
7	extracutaneous mastocytoma	10.4	CD2 PTPRC
8	histiocytoma	10.4	ALK PTPRC SERPINA3
9	alk-positive anaplastic large cell lymphoma	10.4	ALK NPM1
10	breast lymphoma	10.3	BCL6 CD5 CD79A
11	tracheal lymphoma	10.3	CD5 MME
12	hodgkin's lymphoma, lymphocytic-histiocytic predominance	10.3	BCL6 PTPRC
13	liver inflammatory pseudotumor	10.3	PTPRC UCHL1
14	hodgkin's lymphoma, mixed cellularity	10.3	PTPRC UCHL1
15	lymphoplasmacyte-rich meningioma	10.3	CD79A UCHL1
16	plasmacytoma	10.3	CD79A IL2 PTPRC
17	cortical thymoma	10.3	CD2 TTN
18	t-cell adult acute lymphocytic leukemia	10.3	CD2 CD5 IL2
19	lethal midline granuloma	10.3	CD2 NCAM1
20	lobomycosis	10.3	CD19 CD2
21	mediastinal cancer	10.3	CD5 CD79A NCAM1
22	t cell deficiency	10.3	CD2 IL2 PTPRC
23	myeloid sarcoma	10.2	NCAM1 NPM1 PTPRC
24	intravascular large b-cell lymphoma	10.2	BCL6 CD5 MME
25	myasthenia gravis	10.2	IL2 MUSK TTN
26	respiratory system disease	10.2	AKT1 ALK IL2
27	heart lymphoma	10.2	BCL6 MME PTPRC
28	central nervous system leukemia	10.2	CD19 MME
29	testicular lymphoma	10.2	BCL6 MME PTPRC
30	intestinal disease	10.2	AKT1 BCL6 IL2
31	autonomic nervous system neoplasm	10.2	AKT1 ALK NCAM1
32	peripheral nervous system neoplasm	10.2	AKT1 ALK NCAM1
33	autoimmune disease of musculoskeletal system	10.2	CD19 IL2 MUSK
34	invasive malignant thymoma	10.2	CD19 MME
35	thymus lipoma	10.2	CD5 PTPRC TNFRSF8
36	gastric small cell carcinoma	10.2	NCAM1 PTPRC UCHL1
37	congenital hypogammaglobulinemia	10.2	CD19 CD79A
38	immune system organ benign neoplasm	10.2	CD5 PTPRC TNFRSF8
39	lung combined type small cell carcinoma	10.2	MME NCAM1
40	histiocytosis	10.2	PTPRC SERPINA3 TNFRSF8
41	autoimmune lymphoproliferative syndrome, type v	10.2	ALK BCL6 CD5 SH2D1A
42	anterior scleritis	10.2	CD19 CD5 NCAM1
43	selective igg deficiency disease	10.2	CD19 CD79A NCAM1
44	extrahepatic bile duct adenocarcinoma	10.2	MME NCAM1
45	solitary osseous plasmacytoma	10.2	CD19 CD79A NCAM1
46	testicular infarct	10.2	PTPRC TNFRSF8 UCHL1
47	mediastinal malignant lymphoma	10.2	BCL6 CD79A TNFRSF8
48	composite lymphoma	10.2	BCL6 CD5
49	endometrial small cell carcinoma	10.2	NCAM1 PTPRC
50	reticulum cell sarcoma	10.1	CD2 PTPRC TNFRSF8

Graphical network of the top 20 diseases related to Lymphatic System Cancer:

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Symptoms & Phenotypes for Lymphatic System Cancer

MGI Mouse Phenotypes related to Lymphatic System Cancer:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.21	AKT1 BCL6 CD19 CD5 CD79A IL2
2	homeostasis/metabolism	MP:0005376	10.18	AKT1 ALK BCL6 CD19 CD79A IL2
3	immune system	MP:0005387	10.18	AKT1 BCL6 CD19 CD5 CD79A IL2
4	integument	MP:0010771	9.92	AKT1 ALK CD19 CD5 MME MUSK
5	liver/biliary system	MP:0005370	9.91	AKT1 BCL6 CD19 CD79A IL2 MME
6	neoplasm	MP:0002006	9.76	AKT1 ALK CD19 CD79A IL2 NPM1
7	normal	MP:0002873	9.56	AKT1 BCL6 CD19 CD2 CD5 CD79A
8	respiratory system	MP:0005388	9.17	AKT1 ALK BCL6 IL2 MUSK PTPRC

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Drugs & Therapeutics for Lymphatic System Cancer

Drugs for Lymphatic System Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Antibodies, Blocking
2	Immunologic Factors
3	Antibodies
4	Immunotoxins
5	Immunoglobulins

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Collection of Human Samples to Study Hairy Cell and Other Leukemias, and to Develop Recombinant Immunotoxins for Cancer Treatment	Recruiting	NCT01087333

Search NIH Clinical Center for Lymphatic System Cancer

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Genetic Tests for Lymphatic System Cancer

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Anatomical Context for Lymphatic System Cancer

MalaCards organs/tissues related to Lymphatic System Cancer:

⁴²

B Cells, T Cells, Lung, Myeloid, Thymus, Lymph Node, Spleen

The Foundational Model of Anatomy Ontology organs/tissues related to Lymphatic System Cancer:

²⁰

The Lymphatic System

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Publications for Lymphatic System Cancer

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Genes for Lymphatic System Cancer

Genes related to Lymphatic System Cancer (0 elite genes):

(show all 23)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SERPINA3	Serpin Family A Member 3	Protein Coding	18.78	DISEASES inferred ¹⁵ ¹⁵
2	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	17.42	DISEASES inferred ¹⁵
3	ZNF23	Zinc Finger Protein 23	Protein Coding	17.41	DISEASES inferred ¹⁵ ¹⁵
4	CD5	CD5 Molecule	Protein Coding	17.38	DISEASES inferred ¹⁵
5	NPM1	Nucleophosmin 1	Protein Coding	17.18	DISEASES inferred ¹⁵
6	TTN	Titin	Protein Coding	16.86	DISEASES inferred ¹⁵
7	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	16.66	DISEASES inferred ¹⁵
8	MUSK	Muscle Associated Receptor Tyrosine Kinase	Protein Coding	16.61	DISEASES inferred ¹⁵
9	BCL6	BCL6 Transcription Repressor	Protein Coding	16.57	DISEASES inferred ¹⁵
10	CD79A	CD79a Molecule	Protein Coding	16.42	DISEASES inferred ¹⁵
11	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	16.4	DISEASES inferred ¹⁵
12	IL2	Interleukin 2	Protein Coding	16.38	DISEASES inferred ¹⁵
13	UCHL1	Ubiquitin C-Terminal Hydrolase L1	Protein Coding	16.32	DISEASES inferred ¹⁵
14	CD2	CD2 Molecule	Protein Coding	16.18	DISEASES inferred ¹⁵
15	CD19	CD19 Molecule	Protein Coding	16.15	DISEASES inferred ¹⁵
16	SH2D1A	SH2 Domain Containing 1A	Protein Coding	16.12	DISEASES inferred ¹⁵
17	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	16.05	DISEASES inferred ¹⁵
18	MME	Membrane Metalloendopeptidase	Protein Coding	16.03	DISEASES inferred ¹⁵
19	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	8.31	DISEASES inferred ¹⁵
20	SPN	Sialophorin	Protein Coding	6.22	DISEASES inferred ¹⁵
21	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	6	DISEASES inferred ¹⁵
22	DPYSL5	Dihydropyrimidinase Like 5	Protein Coding	5.93	DISEASES inferred ¹⁵
23	PHYH	Phytanoyl-CoA 2-Hydroxylase	Protein Coding	5.87	DISEASES inferred ¹⁵

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Variations for Lymphatic System Cancer

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Expression for Lymphatic System Cancer

Search GEO for disease gene expression data for Lymphatic System Cancer.

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Pathways for Lymphatic System Cancer

Pathways related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁷ Show member pathways Immune System ⁶⁷ Neutrophil degranulation ⁶⁷	13.84	AKT1 BCL6 CD19 CD79A IL2 MME
2	Immune response Fc epsilon RI pathway ²³ Show member pathways Fc epsilon RI signaling pathway ³⁸ Fc-epsilon receptor I signaling in mast cells ¹ Immune response BCR pathway ²³ VEGF signaling pathway ³⁸	12.39	AKT1 BCL6 CD19 CD79A PTPRC
3	NF-kappaB Signaling ⁴	12.32	BCL6 CD19 CD2 CD79A IL2 NCAM1
4	B Cell Receptor Signaling Pathway (sino) ⁶⁸ Show member pathways T Cell Receptor Signaling Pathway ⁶⁸	12.11	AKT1 BCL6 CD19 PTPRC
5	B cell receptor signaling pathway (KEGG) ³⁸ Show member pathways B Cell Receptor Signaling Pathway ¹ BCR signaling pathway ¹	12.09	AKT1 BCL6 CD19 CD79A PTPRC
6	Cell adhesion molecules (CAMs) ³⁸	11.9	CD2 NCAM1 PTPRC SPN
7	Hematopoietic cell lineage ³⁸	11.66	CD19 CD2 CD5 MME
8	Dendritic Cells Developmental Lineage Pathway ⁶⁶	11.6	CD19 IL2 MME NCAM1 PTPRC SPN
9	Innate Lymphoid Cell Differentiation Pathways ⁶⁶	11.57	IL2 NCAM1 PTPRC
10	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁶	11.34	CD19 CD2 CD5 CD79A IL2 MME
11	B Cell Development Pathways ⁶⁶	11.22	BCL6 CD19 CD5 MME PTPRC SPN
12	Primary immunodeficiency ³⁸	11.15	CD19 CD79A PTPRC

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GO Terms for Lymphatic System Cancer

Cellular components related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	9.97	AKT1 ALK CD19 CD2 CD5 CD79A
2	integral component of plasma membrane	GO:0005887	9.56	ALK CD19 CD2 CD5 MME MUSK
3	external side of plasma membrane	GO:0009897	9.1	CD19 CD2 CD5 CD79A NCAM1 PTPRC

Biological processes related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface receptor signaling pathway	GO:0007166	9.65	CD2 CD79A PTPRC
2	B cell differentiation	GO:0030183	9.54	BCL6 CD79A PTPRC
3	positive regulation of regulatory T cell differentiation	GO:0045591	9.46	BCL6 IL2
4	positive regulation of tumor necrosis factor biosynthetic process	GO:0042535	9.43	SPN TNFRSF8
5	positive regulation of isotype switching to IgG isotypes	GO:0048304	9.4	IL2 PTPRC
6	positive regulation of protein phosphorylation	GO:0001934	9.33	AKT1 IL2 MUSK
7	negative regulation of B cell apoptotic process	GO:0002903	9.32	BCL6 IL2
8	cellular defense response	GO:0006968	9.26	SH2D1A SPN
9	positive regulation of B cell proliferation	GO:0030890	9.13	BCL6 IL2 PTPRC
10	negative regulation of apoptotic process	GO:0043066	8.92	AKT1 BCL6 IL2 NPM1

Molecular functions related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	9.89	AKT1 ALK BCL6 CD19 CD2 CD5
2	transmembrane signaling receptor activity	GO:0004888	8.92	CD5 CD79A SPN TNFRSF8

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Sources for Lymphatic System Cancer

¹ BioSystems

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²¹ GeneAnalytics

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²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

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³³ HPO

³⁴ ICD10

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⁵⁴ NIH Rare Diseases

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⁵⁶ Novoseek

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⁶⁹ SNOMED-CT

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⁷² TGDB

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