MCID: LYM023
MIFTS: 30

Lymphatic System Cancer

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Lymphatic System Cancer

MalaCards integrated aliases for Lymphatic System Cancer:

Name: Lymphatic System Cancer 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060073

Summaries for Lymphatic System Cancer

Disease Ontology : 12 An immune system cancer that is located in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue.

MalaCards based summary : Lymphatic System Cancer is related to lymphangiosarcoma and lymph node cancer. An important gene associated with Lymphatic System Cancer is ALK (ALK Receptor Tyrosine Kinase), and among its related pathways/superpathways are Immune response Fc epsilon RI pathway and NF-kappaB Signaling. The drugs Immunotoxins and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and lymph node, and related phenotypes are hematopoietic system and immune system

Related Diseases for Lymphatic System Cancer

Diseases related to Lymphatic System Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 lymphangiosarcoma 31.5 LYZ MYC SMUG1
2 lymph node cancer 11.0
3 spleen cancer 11.0
4 prostate lymphoma 10.3 CD5 SMUG1
5 bone lymphoma 10.3 BCL6 SMUG1
6 brain sarcoma 10.3 PTPRC SMUG1
7 alk-positive anaplastic large cell lymphoma 10.2 ALK NPM1
8 gallbladder small cell carcinoma 10.2 NCAM1 SMUG1
9 liver inflammatory pseudotumor 10.2 PTPRC UCHL1
10 extracutaneous mastocytoma 10.2 CD2 PTPRC
11 tracheal lymphoma 10.2 CD5 MME
12 lymphoplasmacyte-rich meningioma 10.2 CD79A UCHL1
13 viral esophagitis 10.2 CD79A TIA1
14 orbit lymphoma 10.2 NCAM1 TIA1
15 high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement 10.2 BCL6 MYC
16 lymphomatoid papulosis 10.2 ALK NPM1 TIA1
17 myeloid sarcoma 10.2 NCAM1 NPM1 PTPRC
18 lung combined type small cell carcinoma 10.2 MME NCAM1
19 composite lymphoma 10.2 BCL6 CD5 TIA1
20 gastric small cell carcinoma 10.2 NCAM1 PTPRC UCHL1
21 congenital hypogammaglobulinemia 10.2 CD19 CD79A
22 central nervous system leukemia 10.2 CD19 MME
23 parasitic ichthyosporea infectious disease 10.2 NCAM1 TIA1
24 intravascular large b-cell lymphoma 10.2 BCL6 CD5 MME
25 rhinosporidiosis 10.2 NCAM1 TIA1
26 heart lymphoma 10.2 BCL6 MME PTPRC
27 extrahepatic bile duct adenocarcinoma 10.2 MME NCAM1
28 central nervous system hematologic cancer 10.2 BCL6 MME SMUG1
29 testicular lymphoma 10.2 BCL6 MME PTPRC
30 invasive malignant thymoma 10.1 CD19 MME
31 selective igg deficiency disease 10.1 CD19 CD79A NCAM1
32 endometrial small cell carcinoma 10.1 NCAM1 PTPRC
33 anterior scleritis 10.1 CD19 CD5 NCAM1
34 breast lymphoma 10.1 BCL6 CD5 CD79A SMUG1
35 solitary osseous plasmacytoma 10.1 CD19 CD79A NCAM1
36 primary mediastinal large b-cell lymphoma 10.1 BCL6 MYC
37 respiratory system cancer 10.1 ALK MYC SMUG1
38 malignant epithelioid hemangioendothelioma 10.1 MYC SMUG1
39 plasmablastic lymphoma 10.1 BCL6 MYC PTPRC
40 encephalitozoonosis 10.1 CD19 PHYH
41 primary cutaneous anaplastic large cell lymphoma 10.1 ALK NPM1 PTPRC TIA1
42 malignant giant cell tumor of soft parts 10.1 LYZ PTPRC
43 t-cell adult acute lymphocytic leukemia 10.1 CD2 CD5 TIA1
44 intestinal disease 10.1 BCL6 MYC SMUG1
45 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.1 BCL6 PHYH PTPRC
46 plasmacytoma 10.1 CD79A MYC PTPRC
47 mediastinal cancer 10.1 CD5 CD79A NCAM1 SMUG1
48 plasma protein metabolism disease 10.1 CD19 CD5 MME
49 thymoma 10.1 CD2 CD5 PTPRC
50 pericoronitis 10.1 CD19 CD2 NCAM1

Graphical network of the top 20 diseases related to Lymphatic System Cancer:



Diseases related to Lymphatic System Cancer

Symptoms & Phenotypes for Lymphatic System Cancer

MGI Mouse Phenotypes related to Lymphatic System Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.25 BCL6 CD19 CD5 CD79A LYZ MYC
2 immune system MP:0005387 10.21 BCL6 CD19 CD5 CD79A LYZ MME
3 homeostasis/metabolism MP:0005376 10.18 ALK BCL6 CD19 CD79A LYZ MME
4 liver/biliary system MP:0005370 9.96 BCL6 CD19 CD79A LYZ MME MYC
5 integument MP:0010771 9.92 ALK CD19 CD5 LYZ MME MYC
6 neoplasm MP:0002006 9.81 ALK CD19 CD79A LYZ MYC NPM1
7 nervous system MP:0003631 9.7 ALK CD19 CD5 CD79A LYZ MYC
8 normal MP:0002873 9.23 BCL6 CD19 CD2 CD5 CD79A LYZ

Drugs & Therapeutics for Lymphatic System Cancer

Drugs for Lymphatic System Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunotoxins
2 Immunologic Factors
3 Antibodies
4 Antibodies, Blocking
5 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Collection of Human Samples to Study Hairy Cell and Other Leukemias, and to Develop Recombinant Immunotoxins for Cancer Treatment Recruiting NCT01087333

Search NIH Clinical Center for Lymphatic System Cancer

Genetic Tests for Lymphatic System Cancer

Anatomical Context for Lymphatic System Cancer

MalaCards organs/tissues related to Lymphatic System Cancer:

41
Lung, Bone, Lymph Node, T Cells, B Cells, Thymus, Myeloid

The Foundational Model of Anatomy Ontology organs/tissues related to Lymphatic System Cancer:

19
The Lymphatic System

Publications for Lymphatic System Cancer

Variations for Lymphatic System Cancer

Expression for Lymphatic System Cancer

Search GEO for disease gene expression data for Lymphatic System Cancer.

Pathways for Lymphatic System Cancer

GO Terms for Lymphatic System Cancer

Cellular components related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.5 ALK CD19 CD2 CD5 MME PTPRC
2 external side of plasma membrane GO:0009897 9.1 CD19 CD2 CD5 CD79A NCAM1 PTPRC

Biological processes related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.56 CD19 CD2 CD79A PTPRC
2 B cell receptor signaling pathway GO:0050853 9.5 CD19 CD79A PTPRC
3 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.16 SPN TNFRSF8
4 B cell differentiation GO:0030183 9.13 BCL6 CD79A PTPRC
5 cellular defense response GO:0006968 8.8 CD19 SH2D1A SPN

Molecular functions related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.02 ALK CD5 CD79A SPN TNFRSF8

Sources for Lymphatic System Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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