Lymphatic System Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lymphatic System Cancer

MalaCards integrated aliases for Lymphatic System Cancer:

Name: Lymphatic System Cancer ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060073

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Summaries for Lymphatic System Cancer

Disease Ontology : ¹² An immune system cancer that is located in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue.

MalaCards based summary : Lymphatic System Cancer is related to lymphangiosarcoma and lymph node cancer. An important gene associated with Lymphatic System Cancer is ALK (ALK Receptor Tyrosine Kinase), and among its related pathways/superpathways are Immune response Fc epsilon RI pathway and NF-kappaB Signaling. The drugs Immunotoxins and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and lymph node, and related phenotypes are hematopoietic system and immune system

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Related Diseases for Lymphatic System Cancer

Diseases related to Lymphatic System Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)

#	Related Disease	Score	Top Affiliating Genes
1	lymphangiosarcoma	31.5	LYZ MYC SMUG1
2	lymph node cancer	11.0
3	spleen cancer	11.0
4	prostate lymphoma	10.3	CD5 SMUG1
5	bone lymphoma	10.3	BCL6 SMUG1
6	brain sarcoma	10.3	PTPRC SMUG1
7	alk-positive anaplastic large cell lymphoma	10.2	ALK NPM1
8	gallbladder small cell carcinoma	10.2	NCAM1 SMUG1
9	liver inflammatory pseudotumor	10.2	PTPRC UCHL1
10	extracutaneous mastocytoma	10.2	CD2 PTPRC
11	tracheal lymphoma	10.2	CD5 MME
12	lymphoplasmacyte-rich meningioma	10.2	CD79A UCHL1
13	viral esophagitis	10.2	CD79A TIA1
14	orbit lymphoma	10.2	NCAM1 TIA1
15	high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement	10.2	BCL6 MYC
16	lymphomatoid papulosis	10.2	ALK NPM1 TIA1
17	myeloid sarcoma	10.2	NCAM1 NPM1 PTPRC
18	lung combined type small cell carcinoma	10.2	MME NCAM1
19	composite lymphoma	10.2	BCL6 CD5 TIA1
20	gastric small cell carcinoma	10.2	NCAM1 PTPRC UCHL1
21	congenital hypogammaglobulinemia	10.2	CD19 CD79A
22	central nervous system leukemia	10.2	CD19 MME
23	parasitic ichthyosporea infectious disease	10.2	NCAM1 TIA1
24	intravascular large b-cell lymphoma	10.2	BCL6 CD5 MME
25	rhinosporidiosis	10.2	NCAM1 TIA1
26	heart lymphoma	10.2	BCL6 MME PTPRC
27	extrahepatic bile duct adenocarcinoma	10.2	MME NCAM1
28	central nervous system hematologic cancer	10.2	BCL6 MME SMUG1
29	testicular lymphoma	10.2	BCL6 MME PTPRC
30	invasive malignant thymoma	10.1	CD19 MME
31	selective igg deficiency disease	10.1	CD19 CD79A NCAM1
32	endometrial small cell carcinoma	10.1	NCAM1 PTPRC
33	anterior scleritis	10.1	CD19 CD5 NCAM1
34	breast lymphoma	10.1	BCL6 CD5 CD79A SMUG1
35	solitary osseous plasmacytoma	10.1	CD19 CD79A NCAM1
36	primary mediastinal large b-cell lymphoma	10.1	BCL6 MYC
37	respiratory system cancer	10.1	ALK MYC SMUG1
38	malignant epithelioid hemangioendothelioma	10.1	MYC SMUG1
39	plasmablastic lymphoma	10.1	BCL6 MYC PTPRC
40	encephalitozoonosis	10.1	CD19 PHYH
41	primary cutaneous anaplastic large cell lymphoma	10.1	ALK NPM1 PTPRC TIA1
42	malignant giant cell tumor of soft parts	10.1	LYZ PTPRC
43	t-cell adult acute lymphocytic leukemia	10.1	CD2 CD5 TIA1
44	intestinal disease	10.1	BCL6 MYC SMUG1
45	hodgkin's lymphoma, lymphocytic-histiocytic predominance	10.1	BCL6 PHYH PTPRC
46	plasmacytoma	10.1	CD79A MYC PTPRC
47	mediastinal cancer	10.1	CD5 CD79A NCAM1 SMUG1
48	plasma protein metabolism disease	10.1	CD19 CD5 MME
49	thymoma	10.1	CD2 CD5 PTPRC
50	pericoronitis	10.1	CD19 CD2 NCAM1

Graphical network of the top 20 diseases related to Lymphatic System Cancer:

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Symptoms & Phenotypes for Lymphatic System Cancer

MGI Mouse Phenotypes related to Lymphatic System Cancer:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.25	BCL6 CD19 CD5 CD79A LYZ MYC
2	immune system	MP:0005387	10.21	BCL6 CD19 CD5 CD79A LYZ MME
3	homeostasis/metabolism	MP:0005376	10.18	ALK BCL6 CD19 CD79A LYZ MME
4	liver/biliary system	MP:0005370	9.96	BCL6 CD19 CD79A LYZ MME MYC
5	integument	MP:0010771	9.92	ALK CD19 CD5 LYZ MME MYC
6	neoplasm	MP:0002006	9.81	ALK CD19 CD79A LYZ MYC NPM1
7	nervous system	MP:0003631	9.7	ALK CD19 CD5 CD79A LYZ MYC
8	normal	MP:0002873	9.23	BCL6 CD19 CD2 CD5 CD79A LYZ

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Drugs & Therapeutics for Lymphatic System Cancer

Drugs for Lymphatic System Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Immunotoxins
2	Immunologic Factors
3	Antibodies
4	Antibodies, Blocking
5	Immunoglobulins

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Collection of Human Samples to Study Hairy Cell and Other Leukemias, and to Develop Recombinant Immunotoxins for Cancer Treatment	Recruiting	NCT01087333

Search NIH Clinical Center for Lymphatic System Cancer

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Genetic Tests for Lymphatic System Cancer

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Anatomical Context for Lymphatic System Cancer

MalaCards organs/tissues related to Lymphatic System Cancer:

⁴¹

Lung, Bone, Lymph Node, T Cells, B Cells, Thymus, Myeloid

The Foundational Model of Anatomy Ontology organs/tissues related to Lymphatic System Cancer:

¹⁹

The Lymphatic System

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Publications for Lymphatic System Cancer

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Genes for Lymphatic System Cancer

Genes related to Lymphatic System Cancer (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	17.64	DISEASES inferred ¹⁵
2	NPM1	Nucleophosmin 1	Protein Coding	17.46	DISEASES inferred ¹⁵
3	SMUG1	Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1	Protein Coding	16.84	DISEASES inferred ¹⁵
4	BCL6	BCL6, Transcription Repressor	Protein Coding	16.8	DISEASES inferred ¹⁵
5	CD5	CD5 Molecule	Protein Coding	16.73	DISEASES inferred ¹⁵
6	PTPRC	Protein Tyrosine Phosphatase, Receptor Type C	Protein Coding	16.69	DISEASES inferred ¹⁵
7	UCHL1	Ubiquitin C-Terminal Hydrolase L1	Protein Coding	16.55	DISEASES inferred ¹⁵
8	CD79A	CD79a Molecule	Protein Coding	16.46	DISEASES inferred ¹⁵
9	SH2D1A	SH2 Domain Containing 1A	Protein Coding	16.45	DISEASES inferred ¹⁵
10	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	16.24	DISEASES inferred ¹⁵
11	CD19	CD19 Molecule	Protein Coding	16.2	DISEASES inferred ¹⁵
12	TIA1	TIA1 Cytotoxic Granule Associated RNA Binding Protein	Protein Coding	16.14	DISEASES inferred ¹⁵
13	CD2	CD2 Molecule	Protein Coding	16.08	DISEASES inferred ¹⁵
14	MME	Membrane Metalloendopeptidase	Protein Coding	16.07	DISEASES inferred ¹⁵
15	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	16.01	DISEASES inferred ¹⁵
16	PHYH	Phytanoyl-CoA 2-Hydroxylase	Protein Coding	15.95	DISEASES inferred ¹⁵
17	LYZ	Lysozyme	Protein Coding	15.81	DISEASES inferred ¹⁵
18	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	8.57	DISEASES inferred ¹⁵
19	SPN	Sialophorin	Protein Coding	6.33	DISEASES inferred ¹⁵

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Variations for Lymphatic System Cancer

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Expression for Lymphatic System Cancer

Search GEO for disease gene expression data for Lymphatic System Cancer.

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Pathways for Lymphatic System Cancer

Pathways related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Immune response Fc epsilon RI pathway ²² Show member pathways Fc epsilon RI signaling pathway ³⁷ Fc-epsilon receptor I signaling in mast cells ¹ Immune response BCR pathway ²² VEGF signaling pathway ³⁷	12.29	BCL6 CD19 CD79A PTPRC
2	NF-kappaB Signaling ⁴	12.27	BCL6 CD19 CD2 CD79A NCAM1 PTPRC
3	B cell receptor signaling pathway (KEGG) ³⁷ Show member pathways B Cell Receptor Signaling Pathway ¹ BCR signaling pathway ¹	12.09	BCL6 CD19 CD79A MYC PTPRC
4	Cell adhesion molecules (CAMs) ³⁷	11.89	CD2 NCAM1 PTPRC SPN
5	Hematopoietic cell lineage ³⁷	11.66	CD19 CD2 CD5 MME
6	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.62	CD19 CD2 CD5 CD79A MME NCAM1
7	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.52	CD19 MME NCAM1 PTPRC SPN
8	Primary immunodeficiency ³⁷	11.15	CD19 CD79A PTPRC
9	B Cell Development Pathways ⁶⁵	10.89	BCL6 CD19 CD5 MME PTPRC SPN

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GO Terms for Lymphatic System Cancer

Cellular components related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	9.5	ALK CD19 CD2 CD5 MME PTPRC
2	external side of plasma membrane	GO:0009897	9.1	CD19 CD2 CD5 CD79A NCAM1 PTPRC

Biological processes related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface receptor signaling pathway	GO:0007166	9.56	CD19 CD2 CD79A PTPRC
2	B cell receptor signaling pathway	GO:0050853	9.5	CD19 CD79A PTPRC
3	positive regulation of tumor necrosis factor biosynthetic process	GO:0042535	9.16	SPN TNFRSF8
4	B cell differentiation	GO:0030183	9.13	BCL6 CD79A PTPRC
5	cellular defense response	GO:0006968	8.8	CD19 SH2D1A SPN

Molecular functions related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane signaling receptor activity	GO:0004888	9.02	ALK CD5 CD79A SPN TNFRSF8

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Sources for Lymphatic System Cancer

¹ BioSystems

² BitterDB

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⁴ Cell Signaling Technology

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