MCID: LYM023
MIFTS: 26

Lymphatic System Cancer

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Lymphatic System Cancer

MalaCards integrated aliases for Lymphatic System Cancer:

Name: Lymphatic System Cancer 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060073

Summaries for Lymphatic System Cancer

Disease Ontology : 12 An immune system cancer that is located in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue.

MalaCards based summary : Lymphatic System Cancer is related to lymph node carcinoma and lymphangiosarcoma. An important gene associated with Lymphatic System Cancer is IRF4 (Interferon Regulatory Factor 4), and among its related pathways/superpathways are MicroRNAs in cancer and Alzheimers Disease. Affiliated tissues include lymphatic system and breast.

Related Diseases for Lymphatic System Cancer

Diseases related to Lymphatic System Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 267)
# Related Disease Score Top Affiliating Genes
1 lymph node carcinoma 11.1
2 lymphangiosarcoma 11.1
3 spleen cancer 11.1
4 bacterial infectious disease 10.7 MIR155 ICOSLG H2AC18 CCR6
5 autoimmune disease of exocrine system 10.6 MIR155 ICOSLG H2AC18 CCR6
6 eye degenerative disease 10.6 U2AF1 MIR17 KDM4C ICOSLG H2AC18 CCR6
7 blood protein disease 10.6 MIR17 MIR126 ICOSLG H2AC18 CCR6
8 monoclonal gammopathy of uncertain significance 10.6 U2AF1 MIR126 IRF4 ICOSLG CCR6
9 central nervous system hematologic cancer 10.6 MIR199A1 KDM4C IRF4 CCR6
10 marginal zone b-cell lymphoma 10.6 U2AF1 MIR142 KDM4C IRF4 CCR6
11 extrinsic cardiomyopathy 10.6 MIR21 MIR199A1 MIR142 ICOSLG H2AC18 CCR6
12 pre-malignant neoplasm 10.6 MIR181A1 MIR17 MIR142 H2AC18 CCR6
13 hypersensitivity reaction type iv disease 10.6 MIR155 ICOSLG H2AC18 CCR6
14 lipid storage disease 10.6 MIR21 MIR199A1 MIR155 MIR142 H2AC18 CCR6
15 mature t-cell and nk-cell lymphoma 10.6 MIR199A1 MIR17 MIR126 KDM4C ICOSLG H2AC18
16 chromosomal deletion syndrome 10.6 MIR9-1 MIR17 MIR142 KDM4C ICOSLG H2AC18
17 spinal cord disease 10.6 MIR142 ICOSLG H2AC18 CCR6
18 lymphoma, mucosa-associated lymphoid type 10.6 MIR142 KDM4C IRF4 ICOSLG CCR6
19 parasitic helminthiasis infectious disease 10.6 MIR21 ICOSLG H2AC18 CCR6
20 autoimmune disease of endocrine system 10.6 MIR142 MIR125A ICOSLG H2AC18 CCR6
21 bronchial disease 10.6 MIR21 MIR17 MIR155 MIR142 MIR126 ICOSLG
22 autoimmune disease of the nervous system 10.6 U2AF1 MIR9-1 MIR155 MIR142 MIR126 MIR125A
23 thyroid gland disease 10.6 MIR9-1 MIR199A1 MIR181A1 MIR17 MIR142 MIR125A
24 autoimmune disease of central nervous system 10.6 U2AF1 MIR9-1 MIR155 MIR142 MIR126 MIR125A
25 testicular disease 10.6 MIR199A1 MIR181A1 KDM4C H2AC18 CCR6
26 pleural disease 10.6 MIR199A1 MIR17 MIR125A H2AC18 CCR6
27 colonic benign neoplasm 10.6 MIR20A MIR15A KDM4C H2AC18 CCR6
28 cervix carcinoma 10.6 U2AF1 MIR199A1 MIR142 H2AC18 CCR6
29 bacterial pneumonia 10.6 MIR155 ICOSLG H2AC18 CCR6
30 x-linked recessive disease 10.6 U2AF1 MIR196A1 MIR142 ICOSLG H2AC18 CCR6
31 primary bacterial infectious disease 10.6 MIR21 MIR155 MIR142 MIR125A ICOSLG H2AC18
32 cerebellar disease 10.6 U2AF1 MIR9-1 KDM4C IRF4 H2AC18
33 thymus gland disease 10.6 MIR125A ICOSLG H2AC18 CCR6
34 intestinal benign neoplasm 10.6 MIR21 MIR20A MIR199A1 MIR196A1 MIR17 MIR15A
35 cardiovascular organ benign neoplasm 10.6 MIR15A KDM4C H2AC18 CCR6
36 heart septal defect 10.6 U2AF1 MIR199A1 MIR17 H2AC18
37 gastrointestinal system benign neoplasm 10.6 MIR21 MIR20A MIR199A1 MIR196A1 MIR17 MIR15A
38 thymus cancer 10.6 MIR125A ICOSLG H2AC18 CCR6
39 intrinsic cardiomyopathy 10.6 MIR21 MIR199A1 MIR142 MIR126 ICOSLG H2AC18
40 mycobacterium tuberculosis 1 10.6 MIR21 MIR155 ICOSLG H2AC18 CCR6
41 lymphangioma 10.6 MIR20A MIR15A KDM4C H2AC18 CCR6
42 autoimmune disease of urogenital tract 10.6 ICOSLG H2AC18 CCR6
43 lymphoma, hodgkin, classic 10.6 MIR21 MIR20A MIR155 KDM4C IRF4 ICOSLG
44 bone sarcoma 10.6 MIR9-1 MIR21 MIR199A1 MIR17 MIR142 KDM4C
45 b-cell lymphoma 10.6 MIR34A MIR21 MIR20A MIR17 MIR155 MIR142
46 in situ carcinoma 10.6 MIR181A1 MIR17 MIR142 MIR126 H2AC18
47 hypotrichosis 1 10.6 KDM4C ICOSLG H2AC18 CCR6
48 hair disease 10.6 KDM4C ICOSLG H2AC18 CCR6
49 hereditary lymphedema 10.6 MIR150 KDM4C H2AC18 CCR6
50 heart valve disease 10.6 MIR21 MIR199A1 MIR17 MIR150 MIR126 H2AC18

Graphical network of the top 20 diseases related to Lymphatic System Cancer:



Diseases related to Lymphatic System Cancer

Symptoms & Phenotypes for Lymphatic System Cancer

Drugs & Therapeutics for Lymphatic System Cancer

Search Clinical Trials , NIH Clinical Center for Lymphatic System Cancer

Genetic Tests for Lymphatic System Cancer

Anatomical Context for Lymphatic System Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Lymphatic System Cancer:

19
Lymphatic System

MalaCards organs/tissues related to Lymphatic System Cancer:

40
Breast

Publications for Lymphatic System Cancer

Articles related to Lymphatic System Cancer:

# Title Authors PMID Year
1
How breast cancer chemotherapy increases the risk of leukemia: Thoughts about a case of diffuse large B-cell lymphoma and leukemia after breast cancer chemotherapy. 61
26861804 2016
2
[Risk of neoplasms among workers in the paper-cellulose industry]. 61
1635447 1992

Variations for Lymphatic System Cancer

Expression for Lymphatic System Cancer

Search GEO for disease gene expression data for Lymphatic System Cancer.

Pathways for Lymphatic System Cancer

Pathways related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.89 MIR9-1 MIR34A MIR21 MIR20A MIR199A1 MIR181A1
2 11.63 MIR9-1 MIR21 MIR181A1 MIR125A
3 10.84 MIR9-1 MIR199A1 MIR181A1 MIR150
4 10.21 MIR150 MIR126

GO Terms for Lymphatic System Cancer

Cellular components related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.81 MIR9-1 MIR34A MIR21 MIR17 MIR15A MIR155
2 extracellular space GO:0005615 9.7 MIR21 MIR20A MIR199A1 MIR181A1 MIR17 MIR15A
3 extracellular vesicle GO:1903561 9.17 MIR34A MIR21 MIR20A MIR17 MIR15A MIR126

Biological processes related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.04 MIR34A MIR21 MIR155 MIR125A KDM4C
2 negative regulation of gene expression GO:0010629 9.95 MIR34A MIR21 MIR20A MIR181A1 MIR17 MIR155
3 positive regulation of angiogenesis GO:0045766 9.89 MIR21 MIR20A MIR199A1 MIR126
4 negative regulation of cell migration GO:0030336 9.88 MIR9-1 MIR34A MIR21 MIR126
5 cellular response to hypoxia GO:0071456 9.85 MIR34A MIR17 MIR155 MIR126
6 negative regulation of inflammatory response GO:0050728 9.85 MIR20A MIR181A1 MIR15A MIR155 MIR142 MIR126
7 negative regulation of angiogenesis GO:0016525 9.84 MIR34A MIR21 MIR15A MIR125A
8 positive regulation of inflammatory response GO:0050729 9.83 MIR21 MIR155 MIR126
9 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.83 MIR21 MIR15A MIR155
10 negative regulation of interleukin-6 production GO:0032715 9.82 MIR181A1 MIR155 MIR125A
11 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.77 MIR21 MIR20A MIR17
12 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.74 MIR21 MIR20A MIR199A1
13 negative regulation of sprouting angiogenesis GO:1903671 9.73 MIR34A MIR20A MIR17
14 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.72 MIR20A MIR199A1 MIR196A1 MIR15A MIR155
15 positive regulation of sprouting angiogenesis GO:1903672 9.7 MIR155 MIR126 MIR125A
16 miRNA mediated inhibition of translation GO:0035278 9.7 MIR9-1 MIR21 MIR20A MIR181A1 MIR17 MIR15A
17 positive regulation of activated T cell proliferation GO:0042104 9.69 MIR21 MIR155 ICOSLG
18 negative regulation of toll-like receptor signaling pathway GO:0034122 9.67 MIR17 IRF4
19 negative regulation of cell adhesion molecule production GO:0060354 9.67 MIR20A MIR155
20 negative regulation of hydrogen peroxide-induced cell death GO:1903206 9.67 MIR17 MIR155
21 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.67 MIR34A MIR21 MIR15A
22 negative regulation of cytokine-mediated signaling pathway GO:0001960 9.66 MIR21 MIR125A
23 positive regulation of microglial cell activation GO:1903980 9.65 MIR155 MIR142
24 positive regulation of endothelial cell differentiation GO:0045603 9.65 MIR21 MIR181A1 MIR150
25 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.64 MIR155 MIR125A
26 positive regulation of metalloendopeptidase activity GO:1904685 9.63 MIR21 MIR17
27 negative regulation of vascular wound healing GO:0061044 9.63 MIR34A MIR155
28 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.63 MIR199A1 MIR17 MIR155
29 negative regulation of bicellular tight junction assembly GO:1903347 9.62 MIR155 MIR142
30 negative regulation of regulatory T cell differentiation GO:0045590 9.62 MIR21 MIR155
31 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.61 MIR21 MIR17
32 negative regulation of interleukin-1 alpha production GO:0032690 9.61 MIR181A1 MIR142
33 positive regulation of connective tissue replacement GO:1905205 9.61 MIR34A MIR199A1 MIR155
34 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.58 MIR20A MIR17
35 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.56 MIR20A MIR199A1 MIR17 MIR155
36 gene silencing by miRNA GO:0035195 9.47 MIR125A MIR126 MIR142 MIR150 MIR155 MIR15A
37 negative regulation of vascular endothelial growth factor production GO:1904046 9.43 MIR34A MIR20A MIR199A1 MIR17 MIR15A MIR125A

Molecular functions related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.65 MIR9-1 MIR34A MIR21 MIR20A MIR181A1 MIR17
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.47 MIR9-1 MIR34A MIR21 MIR20A MIR199A1 MIR196A1
3 RNA polymerase II complex binding GO:0000993 9.33 MIR20A MIR126 MIR125A

Sources for Lymphatic System Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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