MCID: LYM023
MIFTS: 24

Lymphatic System Cancer

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Lymphatic System Cancer

MalaCards integrated aliases for Lymphatic System Cancer:

Name: Lymphatic System Cancer 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060073

Summaries for Lymphatic System Cancer

Disease Ontology : 12 An immune system cancer that is located in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue.

MalaCards based summary : Lymphatic System Cancer is related to lymphangiosarcoma and lymph node cancer. An important gene associated with Lymphatic System Cancer is ALK (ALK Receptor Tyrosine Kinase), and among its related pathways/superpathways are Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors and B Cell Development Pathways. The drugs Antibodies and Antibodies, Blocking have been mentioned in the context of this disorder. Affiliated tissues include the lymphatic system, and related phenotypes are nervous system and no phenotypic analysis

Related Diseases for Lymphatic System Cancer

Diseases related to Lymphatic System Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 lymphangiosarcoma 30.6 LYZ MYC
2 lymph node cancer 10.9
3 spleen cancer 10.9
4 alk-positive anaplastic large cell lymphoma 10.8 ALK NPM1
5 high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement 10.7 BCL6 MYC
6 heart lymphoma 10.7 BCL6 PTPRC
7 nodular lymphocyte predominant hodgkin lymphoma 10.7 BCL6 PTPRC
8 testicular lymphoma 10.7 BCL6 PTPRC
9 subcutaneous panniculitis-like t-cell lymphoma 10.7 MYC TIA1
10 lymphomatoid papulosis 10.6 ALK NPM1 TIA1
11 ovarian lymphoma 10.6 MYC PTPRC
12 intravascular large b-cell lymphoma 10.5 BCL6 CD5
13 alk-negative anaplastic large cell lymphoma 10.5 ALK DUSP22
14 primary effusion lymphoma 10.5 BCL6 MYC
15 lymphosarcoma 10.5 BCL6 PTPRC
16 plasmablastic lymphoma 10.4 BCL6 MYC PTPRC
17 mature b-cell neoplasm 10.4 BCL6 MYC PTPRC
18 inflammatory myofibroblastic tumor 10.4 ALK NPM1 TPM3
19 t-cell/histiocyte rich large b cell lymphoma 10.4 BCL6 TNFRSF8
20 breast lymphoma 10.4 ALK BCL6 CD5
21 composite lymphoma 10.3 BCL6 CD5 TIA1
22 b cell prolymphocytic leukemia 10.3 CD5 MYC
23 primary cutaneous anaplastic large cell lymphoma 10.3 ALK NPM1 PTPRC TIA1
24 conventional fibrosarcoma 10.3 PTPRC TNFRSF8
25 testicular infarct 10.3 PTPRC TNFRSF8
26 lymphoma, hodgkin, classic 10.3 ALK BCL6 PTPRC TIA1
27 hodgkin's lymphoma, lymphocytic depletion 10.2 ALK PTPRC TNFRSF8
28 lymphoblastic lymphoma 10.2 BCL6 CD5 PTPRC
29 reticulum cell sarcoma 10.2 PTPRC TNFRSF8
30 mantle cell lymphoma 10.1 BCL6 CD5 MYC
31 cd45 deficiency 10.1 CD5 PTPRC
32 malignant giant cell tumor of soft parts 10.0 LYZ PTPRC
33 mesenchymal cell neoplasm 10.0 ALK FGF19 TPM3
34 anaplastic large cell lymphoma 9.9 ALK NPM1 PTPRC TNFRSF8
35 immune system organ benign neoplasm 9.9 CD5 PTPRC TNFRSF8
36 thymus lipoma 9.9 CD5 PTPRC TNFRSF8
37 childhood kidney cell carcinoma 9.9 ALK TPM3
38 aleukemic leukemia cutis 9.8 LYZ NPM1
39 lung lymphoma 9.7 ALK BCL6 CD5 TNFRSF8
40 adult lymphoma 9.7 ALK CD5 MYC TNFRSF8
41 epidural neoplasm 9.7 BCL6 CD5 PTPRC TNFRSF8
42 granulomatous myositis 9.7 LYZ TNFRSF8
43 lymphoma 9.6 ALK BCL6 MYC NPM1 TNFRSF8
44 reticulohistiocytic granuloma 9.5 LYZ PTPRC TNFRSF8
45 peripheral t-cell lymphoma 9.5 ALK BCL6 CD5 TIA1 TNFRSF8
46 colon lymphoma 9.4 ALK BCL6 CD5 PTPRC TNFRSF8
47 malignant histiocytosis 9.4 LYZ MYC TNFRSF8
48 in situ pulmonary adenocarcinoma 9.4 ALK FGF19 LYZ
49 reticulosarcoma 9.4 ALK BCL6 NPM1 PTPRC TIA1 TNFRSF8
50 diffuse large b-cell lymphoma 9.4 ALK BCL6 CD5 MYC TNFRSF8

Graphical network of the top 20 diseases related to Lymphatic System Cancer:



Diseases related to Lymphatic System Cancer

Symptoms & Phenotypes for Lymphatic System Cancer

MGI Mouse Phenotypes related to Lymphatic System Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.61 ALK CD5 FGF19 LYZ MYC NPM1
2 no phenotypic analysis MP:0003012 9.1 BCL6 CD5 LYZ MYC PTPRC TPM3

Drugs & Therapeutics for Lymphatic System Cancer

Drugs for Lymphatic System Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies
2 Antibodies, Blocking
3 Immunoglobulins
4 Immunotoxins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Collection of Human Samples to Study Hairy Cell and Other Leukemias, and to Develop Recombinant Immunotoxins for Cancer Treatment Recruiting NCT01087333

Search NIH Clinical Center for Lymphatic System Cancer

Genetic Tests for Lymphatic System Cancer

Anatomical Context for Lymphatic System Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Lymphatic System Cancer:

19
The Lymphatic System

Publications for Lymphatic System Cancer

Variations for Lymphatic System Cancer

Expression for Lymphatic System Cancer

Search GEO for disease gene expression data for Lymphatic System Cancer.

Pathways for Lymphatic System Cancer

GO Terms for Lymphatic System Cancer

Biological processes related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.55 ALK BCL6 LTK MYC NPM1
2 cell proliferation GO:0008283 9.35 ALK CD5 DUSP22 LTK MYC
3 regulation of cell proliferation GO:0042127 9.02 ALK BCL6 DUSP22 TFAP2D TNFRSF8

Molecular functions related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 8.92 ALK CD5 LTK TNFRSF8

Sources for Lymphatic System Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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