Lymphatic System Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lymphatic System Cancer

MalaCards integrated aliases for Lymphatic System Cancer:

Name: Lymphatic System Cancer ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060073

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Summaries for Lymphatic System Cancer

Disease Ontology : ¹² An immune system cancer that is located in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue.

MalaCards based summary : Lymphatic System Cancer is related to lymphangiosarcoma and lymph node cancer. An important gene associated with Lymphatic System Cancer is ALK (ALK Receptor Tyrosine Kinase), and among its related pathways/superpathways are Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors and B Cell Development Pathways. The drugs Antibodies and Antibodies, Blocking have been mentioned in the context of this disorder. Affiliated tissues include the lymphatic system, and related phenotypes are nervous system and no phenotypic analysis

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Related Diseases for Lymphatic System Cancer

Diseases related to Lymphatic System Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)

#	Related Disease	Score	Top Affiliating Genes
1	lymphangiosarcoma	30.6	LYZ MYC
2	lymph node cancer	10.9
3	spleen cancer	10.9
4	alk-positive anaplastic large cell lymphoma	10.8	ALK NPM1
5	high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement	10.7	BCL6 MYC
6	heart lymphoma	10.7	BCL6 PTPRC
7	nodular lymphocyte predominant hodgkin lymphoma	10.7	BCL6 PTPRC
8	testicular lymphoma	10.7	BCL6 PTPRC
9	subcutaneous panniculitis-like t-cell lymphoma	10.7	MYC TIA1
10	lymphomatoid papulosis	10.6	ALK NPM1 TIA1
11	ovarian lymphoma	10.6	MYC PTPRC
12	intravascular large b-cell lymphoma	10.5	BCL6 CD5
13	alk-negative anaplastic large cell lymphoma	10.5	ALK DUSP22
14	primary effusion lymphoma	10.5	BCL6 MYC
15	lymphosarcoma	10.5	BCL6 PTPRC
16	plasmablastic lymphoma	10.4	BCL6 MYC PTPRC
17	mature b-cell neoplasm	10.4	BCL6 MYC PTPRC
18	inflammatory myofibroblastic tumor	10.4	ALK NPM1 TPM3
19	t-cell/histiocyte rich large b cell lymphoma	10.4	BCL6 TNFRSF8
20	breast lymphoma	10.4	ALK BCL6 CD5
21	composite lymphoma	10.3	BCL6 CD5 TIA1
22	b cell prolymphocytic leukemia	10.3	CD5 MYC
23	primary cutaneous anaplastic large cell lymphoma	10.3	ALK NPM1 PTPRC TIA1
24	conventional fibrosarcoma	10.3	PTPRC TNFRSF8
25	testicular infarct	10.3	PTPRC TNFRSF8
26	lymphoma, hodgkin, classic	10.3	ALK BCL6 PTPRC TIA1
27	hodgkin's lymphoma, lymphocytic depletion	10.2	ALK PTPRC TNFRSF8
28	lymphoblastic lymphoma	10.2	BCL6 CD5 PTPRC
29	reticulum cell sarcoma	10.2	PTPRC TNFRSF8
30	mantle cell lymphoma	10.1	BCL6 CD5 MYC
31	cd45 deficiency	10.1	CD5 PTPRC
32	malignant giant cell tumor of soft parts	10.0	LYZ PTPRC
33	mesenchymal cell neoplasm	10.0	ALK FGF19 TPM3
34	anaplastic large cell lymphoma	9.9	ALK NPM1 PTPRC TNFRSF8
35	immune system organ benign neoplasm	9.9	CD5 PTPRC TNFRSF8
36	thymus lipoma	9.9	CD5 PTPRC TNFRSF8
37	childhood kidney cell carcinoma	9.9	ALK TPM3
38	aleukemic leukemia cutis	9.8	LYZ NPM1
39	lung lymphoma	9.7	ALK BCL6 CD5 TNFRSF8
40	adult lymphoma	9.7	ALK CD5 MYC TNFRSF8
41	epidural neoplasm	9.7	BCL6 CD5 PTPRC TNFRSF8
42	granulomatous myositis	9.7	LYZ TNFRSF8
43	lymphoma	9.6	ALK BCL6 MYC NPM1 TNFRSF8
44	reticulohistiocytic granuloma	9.5	LYZ PTPRC TNFRSF8
45	peripheral t-cell lymphoma	9.5	ALK BCL6 CD5 TIA1 TNFRSF8
46	colon lymphoma	9.4	ALK BCL6 CD5 PTPRC TNFRSF8
47	malignant histiocytosis	9.4	LYZ MYC TNFRSF8
48	in situ pulmonary adenocarcinoma	9.4	ALK FGF19 LYZ
49	reticulosarcoma	9.4	ALK BCL6 NPM1 PTPRC TIA1 TNFRSF8
50	diffuse large b-cell lymphoma	9.4	ALK BCL6 CD5 MYC TNFRSF8

Graphical network of the top 20 diseases related to Lymphatic System Cancer:

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Symptoms & Phenotypes for Lymphatic System Cancer

MGI Mouse Phenotypes related to Lymphatic System Cancer:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	9.61	ALK CD5 FGF19 LYZ MYC NPM1
2	no phenotypic analysis	MP:0003012	9.1	BCL6 CD5 LYZ MYC PTPRC TPM3

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Drugs & Therapeutics for Lymphatic System Cancer

Drugs for Lymphatic System Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Antibodies
2	Antibodies, Blocking
3	Immunoglobulins
4	Immunotoxins

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Collection of Human Samples to Study Hairy Cell and Other Leukemias, and to Develop Recombinant Immunotoxins for Cancer Treatment	Recruiting	NCT01087333

Search NIH Clinical Center for Lymphatic System Cancer

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Genetic Tests for Lymphatic System Cancer

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Anatomical Context for Lymphatic System Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Lymphatic System Cancer:

¹⁹

The Lymphatic System

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Publications for Lymphatic System Cancer

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Genes for Lymphatic System Cancer

Genes related to Lymphatic System Cancer (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	18.11	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	NPM1	Nucleophosmin 1	Protein Coding	17.85	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	BCL6	B Cell CLL/Lymphoma 6	Protein Coding	16.54	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	TIA1	TIA1 Cytotoxic Granule Associated RNA Binding Protein	Protein Coding	16	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	HNRNPH3	Heterogeneous Nuclear Ribonucleoprotein H3	Protein Coding	15.96	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	PTPRC	Protein Tyrosine Phosphatase, Receptor Type C	Protein Coding	15.88	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	15.83	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	RRP8	Ribosomal RNA Processing 8	Protein Coding	15.77	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	DUSP22	Dual Specificity Phosphatase 22	Protein Coding	15.75	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	TPM3	Tropomyosin 3	Protein Coding	15.55	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	TFAP2D	Transcription Factor AP-2 Delta	Protein Coding	15.43	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	CD5	CD5 Molecule	Protein Coding	15.41	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	LTK	Leukocyte Receptor Tyrosine Kinase	Protein Coding	15.36	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
14	FGF19	Fibroblast Growth Factor 19	Protein Coding	15.24	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
15	LYZ	Lysozyme	Protein Coding	15.23	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
16	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	8.52	DISEASES inferred ¹⁵

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Variations for Lymphatic System Cancer

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Expression for Lymphatic System Cancer

Search GEO for disease gene expression data for Lymphatic System Cancer.

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Pathways for Lymphatic System Cancer

Pathways related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors ⁶⁶ Show member pathways Activation of the TFAP2 (AP-2) family of transcription factors ⁶⁶ Negative regulation of activity of TFAP2 (AP-2) family transcription factors ⁶⁶ TFAP2 (AP-2) family regulates transcription of cell cycle factors ⁶⁶ TFAP2 (AP-2) family regulates transcription of growth factors and their receptors ⁶⁶ TFAP2 (AP-2) family regulates transcription of other transcription factors ⁶⁶ TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation ⁶⁶	11.1	MYC NPM1 TFAP2D
2	B Cell Development Pathways ⁶⁵	10.65	BCL6 CD5 PTPRC TNFRSF8

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GO Terms for Lymphatic System Cancer

Biological processes related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of apoptotic process	GO:0043066	9.55	ALK BCL6 LTK MYC NPM1
2	cell proliferation	GO:0008283	9.35	ALK CD5 DUSP22 LTK MYC
3	regulation of cell proliferation	GO:0042127	9.02	ALK BCL6 DUSP22 TFAP2D TNFRSF8

Molecular functions related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane signaling receptor activity	GO:0004888	8.92	ALK CD5 LTK TNFRSF8

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Sources for Lymphatic System Cancer

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

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¹⁰ dbSNP

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¹⁶ DrugBank

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¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

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⁴⁴ MeSH

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⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

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⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

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⁶⁸ SNOMED-CT

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⁷¹ TGDB

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⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia