MCID: LYM023
MIFTS: 33

Lymphatic System Cancer

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Lymphatic System Cancer

MalaCards integrated aliases for Lymphatic System Cancer:

Name: Lymphatic System Cancer 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060073

Summaries for Lymphatic System Cancer

Disease Ontology : 12 An immune system cancer that is located in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue.

MalaCards based summary : Lymphatic System Cancer is related to lymph node cancer and lymphangiosarcoma. An important gene associated with Lymphatic System Cancer is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Innate Immune System and Immune response Fc epsilon RI pathway. The drugs Antibodies, Blocking and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and lung, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Lymphatic System Cancer

Diseases related to Lymphatic System Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 lymph node cancer 11.1
2 lymphangiosarcoma 11.1
3 spleen cancer 11.1
4 nodular tenosynovitis 10.5 PTPRC SERPINA3
5 dendritic cell thymoma 10.4 CD5 TTN
6 primary cutaneous anaplastic large cell lymphoma 10.4 ALK NPM1 PTPRC
7 extracutaneous mastocytoma 10.4 CD2 PTPRC
8 histiocytoma 10.4 ALK PTPRC SERPINA3
9 alk-positive anaplastic large cell lymphoma 10.4 ALK NPM1
10 breast lymphoma 10.3 BCL6 CD5 CD79A
11 tracheal lymphoma 10.3 CD5 MME
12 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.3 BCL6 PTPRC
13 liver inflammatory pseudotumor 10.3 PTPRC UCHL1
14 hodgkin's lymphoma, mixed cellularity 10.3 PTPRC UCHL1
15 lymphoplasmacyte-rich meningioma 10.3 CD79A UCHL1
16 plasmacytoma 10.3 CD79A IL2 PTPRC
17 cortical thymoma 10.3 CD2 TTN
18 t-cell adult acute lymphocytic leukemia 10.3 CD2 CD5 IL2
19 lethal midline granuloma 10.3 CD2 NCAM1
20 lobomycosis 10.3 CD19 CD2
21 mediastinal cancer 10.3 CD5 CD79A NCAM1
22 t cell deficiency 10.3 CD2 IL2 PTPRC
23 myeloid sarcoma 10.2 NCAM1 NPM1 PTPRC
24 intravascular large b-cell lymphoma 10.2 BCL6 CD5 MME
25 myasthenia gravis 10.2 IL2 MUSK TTN
26 respiratory system disease 10.2 AKT1 ALK IL2
27 heart lymphoma 10.2 BCL6 MME PTPRC
28 central nervous system leukemia 10.2 CD19 MME
29 testicular lymphoma 10.2 BCL6 MME PTPRC
30 intestinal disease 10.2 AKT1 BCL6 IL2
31 autonomic nervous system neoplasm 10.2 AKT1 ALK NCAM1
32 peripheral nervous system neoplasm 10.2 AKT1 ALK NCAM1
33 autoimmune disease of musculoskeletal system 10.2 CD19 IL2 MUSK
34 invasive malignant thymoma 10.2 CD19 MME
35 thymus lipoma 10.2 CD5 PTPRC TNFRSF8
36 gastric small cell carcinoma 10.2 NCAM1 PTPRC UCHL1
37 congenital hypogammaglobulinemia 10.2 CD19 CD79A
38 immune system organ benign neoplasm 10.2 CD5 PTPRC TNFRSF8
39 lung combined type small cell carcinoma 10.2 MME NCAM1
40 histiocytosis 10.2 PTPRC SERPINA3 TNFRSF8
41 autoimmune lymphoproliferative syndrome, type v 10.2 ALK BCL6 CD5 SH2D1A
42 anterior scleritis 10.2 CD19 CD5 NCAM1
43 selective igg deficiency disease 10.2 CD19 CD79A NCAM1
44 extrahepatic bile duct adenocarcinoma 10.2 MME NCAM1
45 solitary osseous plasmacytoma 10.2 CD19 CD79A NCAM1
46 testicular infarct 10.2 PTPRC TNFRSF8 UCHL1
47 mediastinal malignant lymphoma 10.2 BCL6 CD79A TNFRSF8
48 composite lymphoma 10.2 BCL6 CD5
49 endometrial small cell carcinoma 10.2 NCAM1 PTPRC
50 reticulum cell sarcoma 10.1 CD2 PTPRC TNFRSF8

Graphical network of the top 20 diseases related to Lymphatic System Cancer:



Diseases related to Lymphatic System Cancer

Symptoms & Phenotypes for Lymphatic System Cancer

MGI Mouse Phenotypes related to Lymphatic System Cancer:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.21 AKT1 BCL6 CD19 CD5 CD79A IL2
2 homeostasis/metabolism MP:0005376 10.18 AKT1 ALK BCL6 CD19 CD79A IL2
3 immune system MP:0005387 10.18 AKT1 BCL6 CD19 CD5 CD79A IL2
4 integument MP:0010771 9.92 AKT1 ALK CD19 CD5 MME MUSK
5 liver/biliary system MP:0005370 9.91 AKT1 BCL6 CD19 CD79A IL2 MME
6 neoplasm MP:0002006 9.76 AKT1 ALK CD19 CD79A IL2 NPM1
7 normal MP:0002873 9.56 AKT1 BCL6 CD19 CD2 CD5 CD79A
8 respiratory system MP:0005388 9.17 AKT1 ALK BCL6 IL2 MUSK PTPRC

Drugs & Therapeutics for Lymphatic System Cancer

Drugs for Lymphatic System Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies, Blocking
2 Immunologic Factors
3 Antibodies
4 Immunotoxins
5 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Collection of Human Samples to Study Hairy Cell and Other Leukemias, and to Develop Recombinant Immunotoxins for Cancer Treatment Recruiting NCT01087333

Search NIH Clinical Center for Lymphatic System Cancer

Genetic Tests for Lymphatic System Cancer

Anatomical Context for Lymphatic System Cancer

MalaCards organs/tissues related to Lymphatic System Cancer:

42
B Cells, T Cells, Lung, Myeloid, Thymus, Lymph Node, Spleen

The Foundational Model of Anatomy Ontology organs/tissues related to Lymphatic System Cancer:

20
The Lymphatic System

Publications for Lymphatic System Cancer

Variations for Lymphatic System Cancer

Expression for Lymphatic System Cancer

Search GEO for disease gene expression data for Lymphatic System Cancer.

Pathways for Lymphatic System Cancer

GO Terms for Lymphatic System Cancer

Cellular components related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.97 AKT1 ALK CD19 CD2 CD5 CD79A
2 integral component of plasma membrane GO:0005887 9.56 ALK CD19 CD2 CD5 MME MUSK
3 external side of plasma membrane GO:0009897 9.1 CD19 CD2 CD5 CD79A NCAM1 PTPRC

Biological processes related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.65 CD2 CD79A PTPRC
2 B cell differentiation GO:0030183 9.54 BCL6 CD79A PTPRC
3 positive regulation of regulatory T cell differentiation GO:0045591 9.46 BCL6 IL2
4 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.43 SPN TNFRSF8
5 positive regulation of isotype switching to IgG isotypes GO:0048304 9.4 IL2 PTPRC
6 positive regulation of protein phosphorylation GO:0001934 9.33 AKT1 IL2 MUSK
7 negative regulation of B cell apoptotic process GO:0002903 9.32 BCL6 IL2
8 cellular defense response GO:0006968 9.26 SH2D1A SPN
9 positive regulation of B cell proliferation GO:0030890 9.13 BCL6 IL2 PTPRC
10 negative regulation of apoptotic process GO:0043066 8.92 AKT1 BCL6 IL2 NPM1

Molecular functions related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 AKT1 ALK BCL6 CD19 CD2 CD5
2 transmembrane signaling receptor activity GO:0004888 8.92 CD5 CD79A SPN TNFRSF8

Sources for Lymphatic System Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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