Lymphatic System Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lymphatic System Cancer

MalaCards integrated aliases for Lymphatic System Cancer:

Name: Lymphatic System Cancer ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060073

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Summaries for Lymphatic System Cancer

Disease Ontology : ¹² An immune system cancer that is located in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue.

MalaCards based summary : Lymphatic System Cancer is related to lymph node cancer and lymphangiosarcoma. An important gene associated with Lymphatic System Cancer is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Immune response Fc epsilon RI pathway and NF-kappaB Signaling. The drugs Antibodies, Blocking and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include the lymphatic system, and related phenotypes are hematopoietic system and cellular

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Related Diseases for Lymphatic System Cancer

Diseases related to Lymphatic System Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)

#	Related Disease	Score	Top Affiliating Genes
1	lymph node cancer	11.1
2	lymphangiosarcoma	11.1
3	spleen cancer	11.1
4	nodular tenosynovitis	10.5	PTPRC SERPINA3
5	prostate lymphoma	10.4	CD5 SMUG1
6	dendritic cell thymoma	10.4	CD5 TTN
7	heart lymphoma	10.4	BCL6 PTPRC
8	brain sarcoma	10.4	PTPRC SMUG1
9	bone lymphoma	10.4	BCL6 SMUG1
10	splenic tuberculosis	10.4	IL2 SMUG1
11	pharynx squamous cell carcinoma	10.4	AKT1 SMUG1
12	intravascular large b-cell lymphoma	10.4	BCL6 CD5
13	primary cutaneous anaplastic large cell lymphoma	10.4	ALK NPM1 PTPRC
14	alk-positive anaplastic large cell lymphoma	10.4	ALK NPM1
15	histiocytoma	10.4	ALK PTPRC SERPINA3
16	extracutaneous mastocytoma	10.4	CD2 PTPRC
17	hodgkin's lymphoma, lymphocytic-histiocytic predominance	10.4	BCL6 PTPRC
18	testicular lymphoma	10.4	BCL6 PTPRC
19	liver inflammatory pseudotumor	10.3	PTPRC UCHL1
20	connective tissue cancer	10.3	AKT1 SERPINA3 SMUG1
21	lymphoblastic lymphoma	10.3	BCL6 CD5 PTPRC
22	hodgkin's lymphoma, mixed cellularity	10.3	PTPRC UCHL1
23	plasma protein metabolism disease	10.3	CD19 CD5 SERPINA3
24	lymphoplasmacyte-rich meningioma	10.3	CD79A UCHL1
25	marginal zone b-cell lymphoma	10.3	BCL6 CD5 CD79A
26	respiratory system cancer	10.3	AKT1 ALK SMUG1
27	cortical thymoma	10.3	CD2 TTN
28	sternum cancer	10.3	SMUG1 TNFRSF8
29	plasmacytoma	10.3	CD79A IL2 PTPRC
30	bladder lymphoma	10.3	CD19 CD5 CD79A
31	t-cell adult acute lymphocytic leukemia	10.3	CD2 CD5 IL2
32	lobomycosis	10.3	CD19 CD2
33	gallbladder small cell carcinoma	10.3	NCAM1 SMUG1
34	myasthenia gravis	10.2	IL2 MUSK TTN
35	lethal midline granuloma	10.2	CD2 NCAM1
36	t cell deficiency	10.2	CD2 IL2 PTPRC
37	myeloid sarcoma	10.2	NCAM1 NPM1 PTPRC
38	congenital hypogammaglobulinemia	10.2	CD19 CD79A
39	breast lymphoma	10.2	BCL6 CD5 CD79A SMUG1
40	thymus lipoma	10.2	CD5 PTPRC TNFRSF8
41	immune system organ benign neoplasm	10.2	CD5 PTPRC TNFRSF8
42	histiocytosis	10.2	PTPRC SERPINA3 TNFRSF8
43	autonomic nervous system neoplasm	10.2	AKT1 ALK NCAM1
44	composite lymphoma	10.2	BCL6 CD5
45	peripheral nervous system neoplasm	10.2	AKT1 ALK NCAM1
46	autoimmune disease of musculoskeletal system	10.2	CD19 IL2 MUSK
47	respiratory system disease	10.2	AKT1 ALK IL2 SMUG1
48	endometrial small cell carcinoma	10.2	NCAM1 PTPRC
49	gastric small cell carcinoma	10.2	NCAM1 PTPRC UCHL1
50	conventional fibrosarcoma	10.2	PTPRC TNFRSF8

Graphical network of the top 20 diseases related to Lymphatic System Cancer:

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Symptoms & Phenotypes for Lymphatic System Cancer

MGI Mouse Phenotypes related to Lymphatic System Cancer:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.21	AKT1 BCL6 CD19 CD5 CD79A IL2
2	cellular	MP:0005384	10.2	AKT1 BCL6 CD19 CD79A IL2 MUSK
3	immune system	MP:0005387	10.15	AKT1 BCL6 CD19 CD5 CD79A IL2
4	homeostasis/metabolism	MP:0005376	10.14	AKT1 ALK BCL6 CD19 CD79A IL2
5	mortality/aging	MP:0010768	10.03	AKT1 ALK BCL6 CD19 IL2 MUSK
6	liver/biliary system	MP:0005370	9.92	AKT1 BCL6 CD19 CD79A IL2 NPM1
7	neoplasm	MP:0002006	9.81	AKT1 ALK CD19 CD79A IL2 NPM1
8	normal	MP:0002873	9.56	AKT1 BCL6 CD19 CD2 CD5 CD79A
9	respiratory system	MP:0005388	9.17	AKT1 ALK BCL6 IL2 MUSK PTPRC

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Drugs & Therapeutics for Lymphatic System Cancer

Drugs for Lymphatic System Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Antibodies, Blocking
2	Immunoglobulins
3	Immunotoxins
4	Antibodies
5	Immunologic Factors

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Collection of Human Samples to Study Hairy Cell and Other Leukemias, and to Develop Recombinant Immunotoxins for Cancer Treatment	Recruiting	NCT01087333

Search NIH Clinical Center for Lymphatic System Cancer

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Genetic Tests for Lymphatic System Cancer

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Anatomical Context for Lymphatic System Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Lymphatic System Cancer:

²⁰

The Lymphatic System

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Publications for Lymphatic System Cancer

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Genes for Lymphatic System Cancer

Genes related to Lymphatic System Cancer (0 elite genes):

(show all 23)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SERPINA3	Serpin Family A Member 3	Protein Coding	18.76	DISEASES inferred ¹⁵ ¹⁵
2	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	17.4	DISEASES inferred ¹⁵
3	ZNF23	Zinc Finger Protein 23	Protein Coding	17.39	DISEASES inferred ¹⁵ ¹⁵
4	CD5	CD5 Molecule	Protein Coding	17.36	DISEASES inferred ¹⁵
5	NPM1	Nucleophosmin 1	Protein Coding	17.18	DISEASES inferred ¹⁵
6	SMUG1	Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1	Protein Coding	16.94	DISEASES inferred ¹⁵
7	TTN	Titin	Protein Coding	16.84	DISEASES inferred ¹⁵
8	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	16.66	DISEASES inferred ¹⁵
9	MUSK	Muscle Associated Receptor Tyrosine Kinase	Protein Coding	16.6	DISEASES inferred ¹⁵
10	BCL6	BCL6 Transcription Repressor	Protein Coding	16.57	DISEASES inferred ¹⁵
11	CD79A	CD79a Molecule	Protein Coding	16.41	DISEASES inferred ¹⁵
12	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	16.38	DISEASES inferred ¹⁵
13	IL2	Interleukin 2	Protein Coding	16.36	DISEASES inferred ¹⁵
14	UCHL1	Ubiquitin C-Terminal Hydrolase L1	Protein Coding	16.32	DISEASES inferred ¹⁵
15	CD2	CD2 Molecule	Protein Coding	16.17	DISEASES inferred ¹⁵
16	CD19	CD19 Molecule	Protein Coding	16.15	DISEASES inferred ¹⁵
17	SH2D1A	SH2 Domain Containing 1A	Protein Coding	16.12	DISEASES inferred ¹⁵
18	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	16.04	DISEASES inferred ¹⁵
19	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	8.29	DISEASES inferred ¹⁵
20	SPN	Sialophorin	Protein Coding	6.21	DISEASES inferred ¹⁵
21	MME	Membrane Metalloendopeptidase	Protein Coding	6.02	DISEASES inferred ¹⁵
22	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	5.95	DISEASES inferred ¹⁵
23	DPYSL5	Dihydropyrimidinase Like 5	Protein Coding	5.92	DISEASES inferred ¹⁵

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Variations for Lymphatic System Cancer

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Expression for Lymphatic System Cancer

Search GEO for disease gene expression data for Lymphatic System Cancer.

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Pathways for Lymphatic System Cancer

Pathways related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

(show all 11)

#	Super pathways	Score	Top Affiliating Genes
1	Immune response Fc epsilon RI pathway ²³ Show member pathways Fc epsilon RI signaling pathway ³⁸ Fc-epsilon receptor I signaling in mast cells ¹ Immune response BCR pathway ²³ VEGF signaling pathway ³⁸	12.36	AKT1 BCL6 CD19 CD79A PTPRC
2	NF-kappaB Signaling ⁴	12.12	BCL6 CD19 CD2 CD79A IL2 NCAM1
3	B Cell Receptor Signaling Pathway (sino) ⁶⁸ Show member pathways B Cell Receptor Signaling Pathway ⁶⁸	12.09	AKT1 BCL6 CD19 PTPRC
4	B cell receptor signaling pathway (KEGG) ³⁸ Show member pathways B Cell Receptor Signaling Pathway ¹ BCR signaling pathway ¹	12.09	AKT1 BCL6 CD19 CD79A PTPRC
5	Cell adhesion molecules (CAMs) ³⁸	11.86	CD2 NCAM1 PTPRC SPN
6	Hematopoietic cell lineage ³⁸	11.66	CD19 CD2 CD5
7	Innate Lymphoid Cell Differentiation Pathways ⁶⁶	11.56	IL2 NCAM1 PTPRC
8	Dendritic Cells Developmental Lineage Pathway ⁶⁶	11.52	CD19 IL2 NCAM1 PTPRC SPN
9	B Cell Development Pathways ⁶⁶	11.36	BCL6 CD19 CD5 PTPRC SPN TNFRSF8
10	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁶	11.29	CD19 CD2 CD5 CD79A IL2 NCAM1
11	Primary immunodeficiency ³⁸	11.11	CD19 CD79A PTPRC

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GO Terms for Lymphatic System Cancer

Cellular components related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	9.93	AKT1 ALK CD19 CD2 CD5 CD79A
2	integral component of plasma membrane	GO:0005887	9.5	ALK CD19 CD2 CD5 MUSK PTPRC
3	external side of plasma membrane	GO:0009897	9.1	CD19 CD2 CD5 CD79A NCAM1 PTPRC

Biological processes related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface receptor signaling pathway	GO:0007166	9.65	CD2 CD79A PTPRC
2	B cell differentiation	GO:0030183	9.54	BCL6 CD79A PTPRC
3	positive regulation of regulatory T cell differentiation	GO:0045591	9.46	BCL6 IL2
4	positive regulation of tumor necrosis factor biosynthetic process	GO:0042535	9.43	SPN TNFRSF8
5	positive regulation of isotype switching to IgG isotypes	GO:0048304	9.4	IL2 PTPRC
6	positive regulation of protein phosphorylation	GO:0001934	9.33	AKT1 IL2 MUSK
7	negative regulation of B cell apoptotic process	GO:0002903	9.32	BCL6 IL2
8	cellular defense response	GO:0006968	9.26	SH2D1A SPN
9	positive regulation of B cell proliferation	GO:0030890	9.13	BCL6 IL2 PTPRC
10	negative regulation of apoptotic process	GO:0043066	8.92	AKT1 BCL6 IL2 NPM1

Molecular functions related to Lymphatic System Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	9.89	AKT1 ALK BCL6 CD19 CD2 CD5
2	transmembrane signaling receptor activity	GO:0004888	8.92	CD5 CD79A SPN TNFRSF8

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Sources for Lymphatic System Cancer

¹ BioSystems

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²¹ GeneAnalytics

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²⁴ GeneHancer via GeneCards

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³⁴ ICD10

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