Aliases & Classifications for Lymphatic System Disease

MalaCards integrated aliases for Lymphatic System Disease:

Name: Lymphatic System Disease 12 15
Lymphatic Diseases 43 44 73
Adenopathy 12 15
Disorder of Lymph Node and Lymphatics 12
Abnormality of the Lymphatic System 29
Disorder of Lymphatic System 12
Disorder of Lymphoid System 12
Disease of Lympoid System 12
Lympoid System Disease 12
Lymphatic Disorder 12
Lymphatic Disease 12
Lymphangiopathy 12


External Ids:

Disease Ontology 12 DOID:75
MeSH 44 D008206
SNOMED-CT 68 3305006
UMLS 73 C0024228

Summaries for Lymphatic System Disease

MedlinePlus : 43 The lymphatic system is a network of tissues and organs. It is made up of Lymph - a fluid that contains white blood cells that defend against germs Lymph vessels - vessels that carry lymph throughout your body. They are different from blood vessels. Lymph nodes - glands found throughout the lymph vessels. Along with your spleen, these nodes are where white blood cells fight infection. Your bone marrow and thymus produce the cells in lymph. They are part of the system, too. The lymphatic system clears away infection and keeps your body fluids in balance. If it's not working properly, fluid builds in your tissues and causes swelling, called lymphedema. Other lymphatic system problems can include infections, blockage, and cancer.

MalaCards based summary : Lymphatic System Disease, also known as lymphatic diseases, is related to hemophagocytic lymphohistiocytosis and lymphedema, and has symptoms including edema, axillary lymph node pain and axillary lymph node tenderness. An important gene associated with Lymphatic System Disease is UNC13D (Unc-13 Homolog D), and among its related pathways/superpathways are Deregulation of Rab and Rab Effector Genes in Bladder Cancer and VEGF binds to VEGFR leading to receptor dimerization. The drug Sirolimus has been mentioned in the context of this disorder. Affiliated tissues include lymph node, b cells and bone, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 An immune system disease that is located in the lymphatic system.

Wikipedia : 76 Lymphatic disease is a class of disorders which directly affect the components of the lymphatic... more...

Related Diseases for Lymphatic System Disease

Diseases related to Lymphatic System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
# Related Disease Score Top Affiliating Genes
1 hemophagocytic lymphohistiocytosis 31.5 CD5 RAB27A SH2D1A STX11 STXBP2 UNC13D
2 lymphedema 30.2 FLT4 FOXC2 VEGFC
3 periodic fever, aphthous stomatitis, pharyngitis and adenitis 11.7
4 follicular lymphoma 11.1
5 systemic onset juvenile idiopathic arthritis 11.1
6 hennekam syndrome 10.9
7 histiocytosis 10.9
8 lymphangitis 10.9
9 mycosis fungoides 10.9
10 hyper-igd syndrome 10.9
11 astrakhan spotted fever 10.9
12 indian tick typhus 10.9
13 israeli tick typhus 10.9
14 far eastern spotted fever 10.9
15 flinders island spotted fever 10.9
16 japanese spotted fever 10.9
17 mesenteric lymphadenitis 10.9
18 siberian tick typhus 10.9
19 boutonneuse fever 10.9
20 lymphadenitis 10.9
21 lymphedema, hereditary, ia 10.8
22 yellow nail syndrome 10.8
23 lymphangiectasia, pulmonary, congenital 10.8
24 good syndrome 10.3 STX11 UNC13D
25 neural crest tumor 10.3 SDHB SDHD
26 gorham's disease 10.3 FLT4 VEGFC
27 hemangioma of spleen 10.3 FLT4 SMUG1
28 extra-adrenal pheochromocytoma 10.3 SDHB SDHD
29 lymphoproliferative syndrome, x-linked, 2 10.3 SH2D1A STXBP2
30 pharyngitis 10.3
31 stomatitis 10.3
32 eye lymphoma 10.3 CD5 TLR9
33 cerebral lymphoma 10.3 SMUG1 TLR9
34 chediak-higashi syndrome 10.3 CD207 RAB27A UNC13D
35 parapsoriasis 10.2 CD5 TLR9
36 congenital lymphedema 10.2 FLT4 FOXC2 VEGFC
37 prostate lymphoma 10.2 CD5 SMUG1
38 hereditary lymphedema 10.2 FLT4 FOXC2 VEGFC
39 selective immunoglobulin deficiency disease 10.2 SH2D1A STXBP2
40 paragangliomas 1 10.2 SDHB SDHD
41 pulmonary artery leiomyosarcoma 10.2 CD68 SMUG1
42 gastrointestinal tuberculosis 10.2 CRP SMUG1
43 heart cancer 10.2 SDHB SMUG1
44 breast lymphoma 10.2 CD5 SMUG1
45 malignant epithelioid hemangioendothelioma 10.2 FLT4 SMUG1
46 sternum cancer 10.2 CD68 SMUG1
47 aortitis 10.2 CRP SMUG1
48 aphthous stomatitis 10.2
49 brain sarcoma 10.2 CD68 SMUG1
50 central nervous system vasculitis 10.2 CRP SMUG1 TLR9

Graphical network of the top 20 diseases related to Lymphatic System Disease:

Diseases related to Lymphatic System Disease

Symptoms & Phenotypes for Lymphatic System Disease

UMLS symptoms related to Lymphatic System Disease:

edema, axillary lymph node pain, axillary lymph node tenderness

MGI Mouse Phenotypes related to Lymphatic System Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 CD207 CD5 CD68 ITPKC RAB27A SDHB
2 homeostasis/metabolism MP:0005376 9.73 CRP FLT4 FOXC2 RAB27A SDHB SDHD
3 immune system MP:0005387 9.47 CD207 CD5 CD68 CRP FLT4 FOXC2

Drugs & Therapeutics for Lymphatic System Disease

Drugs for Lymphatic System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

# Name Status Phase Clinical Trials Cas Number PubChem Id
Sirolimus Approved, Investigational Phase 1 53123-88-9 46835353 6436030 5284616

Interventional clinical trials:

# Name Status NCT ID Phase Drugs
1 Ultra-Low Dose IL-2 Therapy as GVHD Prophylaxis in Haploidentical Allogeneic Stem Cell Transplantation Completed NCT02226861 Phase 1

Search NIH Clinical Center for Lymphatic System Disease

Cochrane evidence based reviews: lymphatic diseases

Genetic Tests for Lymphatic System Disease

Genetic tests related to Lymphatic System Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Lymphatic System 29

Anatomical Context for Lymphatic System Disease

MalaCards organs/tissues related to Lymphatic System Disease:

Lymph Node, B Cells, Bone, Bone Marrow, T Cells, Spleen, Thymus

The Foundational Model of Anatomy Ontology organs/tissues related to Lymphatic System Disease:

The Lymphatic System

Publications for Lymphatic System Disease

Articles related to Lymphatic System Disease:

# Title Authors Year
Use of Unenhanced MR Lymphography to Characterize Lung Lymphatic Diseases. ( 28639922 )
Reply to "Use of Unenhanced MR Lymphography to Characterize Lung Lymphatic Diseases". ( 28639923 )
Imaging of thoracic lymphatic diseases. ( 19933641 )
Lymphatic diseases. ( 1735059 )
Heterochromatin and nucleolus organizer regions in cells of patients with malignant and premalignant lymphatic diseases. ( 6490006 )
Skin and diabetes. III. Incidence of diabetes in a group of patients with skin disorders caused by venous and/or lymphatic diseases of the leg. ( 4470105 )

Variations for Lymphatic System Disease

Expression for Lymphatic System Disease

Search GEO for disease gene expression data for Lymphatic System Disease.

Pathways for Lymphatic System Disease

Pathways related to Lymphatic System Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.36 RAB27A UNC13D
Show member pathways
10.16 FLT4 VEGFC
3 9.7 RAB27A UNC13D

GO Terms for Lymphatic System Disease

Cellular components related to Lymphatic System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial envelope GO:0005740 9.16 ENSG00000255292 SDHD
2 Weibel-Palade body GO:0033093 8.96 RAB27A UNC13D
3 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.8 ENSG00000255292 SDHB SDHD

Biological processes related to Lymphatic System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.54 FLT4 FOXC2 VEGFC
2 vascular endothelial growth factor signaling pathway GO:0038084 9.48 FLT4 VEGFC
3 lymph vessel development GO:0001945 9.46 FLT4 FOXC2
4 lymphangiogenesis GO:0001946 9.43 FLT4 FOXC2
5 regulation of mast cell degranulation GO:0043304 9.4 STXBP2 UNC13D
6 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.32 ENSG00000255292 SDHD
7 natural killer cell degranulation GO:0043320 9.26 RAB27A UNC13D
8 positive regulation of regulated secretory pathway GO:1903307 9.16 RAB27A UNC13D
9 tricarboxylic acid cycle GO:0006099 9.13 ENSG00000255292 SDHB SDHD
10 exocytosis GO:0006887 8.92 RAB27A STX11 STXBP2 UNC13D

Molecular functions related to Lymphatic System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.96 SDHB SDHD
2 ubiquinone binding GO:0048039 8.8 ENSG00000255292 SDHB SDHD

Sources for Lymphatic System Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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