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MCID: LYM024
MIFTS: 54

Lymphatic System Disease

Categories: Immune diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Lymphatic System Disease

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MalaCards integrated aliases for Lymphatic System Disease:

Name: Lymphatic System Disease 12 15
Lymphatic Diseases 43 44 73
Disorder of Lymph Node and Lymphatics 12
Abnormality of the Lymphatic System 29
Disorder of Lymphatic System 12
Disorder of Lymphoid System 12
Disease of Lympoid System 12
Lympoid System Disease 12
Lymphatic Disorder 12
Lymphatic Disease 12
Lymphangiopathy 12
Adenopathy 12

Classifications:

MalaCards categories:
Anatomical: Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:75
MeSH 44 D008206
UMLS 73 C0024228
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Summaries for Lymphatic System Disease

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MedlinePlus : 43 The lymphatic system is a network of tissues and organs. It is made up of Lymph - a fluid that contains white blood cells that defend against germs Lymph vessels - vessels that carry lymph throughout your body. They are different from blood vessels. Lymph nodes - glands found throughout the lymph vessels. Along with your spleen, these nodes are where white blood cells fight infection. Your bone marrow and thymus produce the cells in lymph. They are part of the system, too. The lymphatic system clears away infection and keeps your body fluids in balance. If it's not working properly, fluid builds in your tissues and causes swelling, called lymphedema. Other lymphatic system problems can include infections, blockage, and cancer.

MalaCards based summary : Lymphatic System Disease, also known as lymphatic diseases, is related to hennekam syndrome and hemophagocytic lymphohistiocytosis, and has symptoms including edema, axillary lymph node pain and axillary lymph node tenderness. An important gene associated with Lymphatic System Disease is UNC13D (Unc-13 Homolog D), and among its related pathways/superpathways are Lysosome and LDL Oxidation in Atherogenesis. The drugs Teniposide and rituximab have been mentioned in the context of this disorder. Affiliated tissues include the lymphatic system, b cells and t cells, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 An immune system disease that is located in the lymphatic system.

Wikipedia : 76 Lymphatic disease is a class of disorders which directly affect the components of the lymphatic... more...

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Related Diseases for Lymphatic System Disease

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Diseases related to Lymphatic System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 hennekam syndrome 32.0 FLT4 GJC2 VEGFC
2 hemophagocytic lymphohistiocytosis 31.9 SH2D1A STX11 STXBP2 UNC13D
3 yellow nail syndrome 31.5 CD40LG FOXC2
4 lymphedema 29.8 FLT4 FOXC2 GJC2 VEGFC
5 periodic fever, aphthous stomatitis, pharyngitis and adenitis 11.6
6 niemann-pick disease type c, severe perinatal form 11.0 NPC1 NPC2
7 niemann-pick disease type c, late infantile neurologic onset 11.0 NPC1 NPC2
8 niemann-pick disease type c, severe early infantile neurologic onset 11.0 NPC1 NPC2
9 niemann-pick disease type c, adult neurologic onset 11.0 NPC1 NPC2
10 niemann-pick disease type c, juvenile neurologic onset 11.0 NPC1 NPC2
11 acid sphingomyelinase deficiency 11.0 NPC1 SMPD1
12 follicular lymphoma 11.0
13 systemic onset juvenile idiopathic arthritis 11.0
14 good syndrome 10.8 STX11 UNC13D
15 hemophagocytic lymphohistiocytosis, familial, 4 10.8 STX11 STXBP2 UNC13D
16 histiocytosis 10.8
17 lymphangitis 10.8
18 mycosis fungoides 10.8
19 hyper-igd syndrome 10.8
20 astrakhan spotted fever 10.8
21 indian tick typhus 10.8
22 israeli tick typhus 10.8
23 far eastern spotted fever 10.8
24 flinders island spotted fever 10.8
25 japanese spotted fever 10.8
26 siberian tick typhus 10.8
27 boutonneuse fever 10.8
28 niemann-pick disease, type c1 10.8 NPC1 NPC2 SMPD1
29 sphingolipidosis 10.8 NPC1 NPC2 SMPD1
30 neural crest tumor 10.8 SDHB SDHD
31 niemann-pick disease 10.7 NPC1 NPC2 SMPD1
32 lipid storage disease 10.7 NPC1 NPC2 SMPD1
33 paragangliomas 1 10.7 SDHB SDHD
34 adrenal medulla cancer 10.7 SDHB SDHD
35 gorham's disease 10.7 FLT4 VEGFC
36 extra-adrenal pheochromocytoma 10.7 SDHB SDHD
37 lymphedema, hereditary, ia 10.7
38 lymphangiectasia, pulmonary, congenital 10.7
39 lymphoproliferative syndrome, x-linked, 2 10.7 SH2D1A STXBP2
40 hereditary lymphedema 10.7 FLT4 FOXC2 GJC2
41 non-langerhans-cell histiocytosis 10.6 CD207 NPC1 NPC2 SMPD1
42 congenital lymphedema 10.6 FLT4 FOXC2 VEGFC
43 borderline leprosy 10.6 CD40LG SDHD
44 lymphangiosarcoma 10.5 FLT4 GJC2 VEGFC
45 selective immunoglobulin deficiency disease 10.4 CD40LG SH2D1A STXBP2
46 persistent generalized lymphadenopathy 10.4 CD40LG SDHB SDHD
47 ocular toxoplasmosis 10.4 CD40LG TLR9
48 granulomatous gastritis 10.4 CD40LG CD68
49 dysgammaglobulinemia 10.4 CD40LG SH2D1A
50 parasitic ichthyosporea infectious disease 10.3 CD40LG CD68

Graphical network of the top 20 diseases related to Lymphatic System Disease:



Diseases related to Lymphatic System Disease
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Symptoms & Phenotypes for Lymphatic System Disease

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UMLS symptoms related to Lymphatic System Disease:


edema, axillary lymph node pain, axillary lymph node tenderness

MGI Mouse Phenotypes related to Lymphatic System Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 SH2D1A CD68 SMPD1 STX11 GJC2 STXBP2
2 homeostasis/metabolism MP:0005376 9.97 SH2D1A FLT4 SMPD1 FOXC2 STX11 TLR9
3 immune system MP:0005387 9.86 SH2D1A CD68 SMPD1 FLT4 FOXC2 STX11
4 mortality/aging MP:0010768 9.4 CD40LG FLT4 SMPD1 FOXC2 GJC2 STXBP2
Sources

Drugs & Therapeutics for Lymphatic System Disease

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Drugs for Lymphatic System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 984)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Teniposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 29767-20-2 34698
2
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 174722-31-7 10201696
3
Gemcitabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 95058-81-4 60750
4
Vidarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 24356-66-9 32326 21704
5
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 135968-09-1
6
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 21679-14-1, 75607-67-9 30751
7
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 33419-42-0 36462
8
Menthol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2216-51-5 16666
9
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15663-27-1 84093 441203 2767
10
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 23214-92-8 31703
11
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 302962-49-8 3062316
12
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-23-7 5754
13
Dacarbazine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 4342-03-4 5351166
14
Denileukin diftitox Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 173146-27-5
15
Vinblastine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 865-21-4 13342 241903
16
Pentostatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53910-25-1 40926 439693
17
Mechlorethamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 51-75-2 4033
18
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 3778-73-2 3690
19
Iron Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 7439-89-6 23925
20
Aprepitant Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 170729-80-3 151165 6918365
21
Dopamine Approved Phase 4,Phase 1,Not Applicable 51-61-6, 62-31-7 681
22
Ganciclovir Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 82410-32-0 3454
23
Azithromycin Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 83905-01-5 55185 447043
24
Mesna Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 3375-50-6 598
25
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2068-78-2, 57-22-7 5978
26
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1959-05-2, 59-05-2 126941
27
Chlorambucil Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 305-03-3 2708
28
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-78-2 2244
29
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 147-94-4 6253
30
Zidovudine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 30516-87-1 35370
31
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
32
Thiotepa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52-24-4 5453
33
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
34
Iloprost Approved, Investigational Phase 4 78919-13-8 6443959
35
Iodine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 7553-56-2 807
36
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
37
Valproic Acid Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable,Early Phase 1 99-66-1 3121
38
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 55-98-1 2478
39
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58957-92-9 42890
40
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
41
Oxaliplatin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 61825-94-3 5310940 9887054 43805 6857599
42
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 159351-69-6 6442177
43
Bortezomib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 179324-69-7 387447 93860
44
Melphalan Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 148-82-3 4053 460612
45
Mycophenolic acid Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 24280-93-1 446541
46
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 65271-80-9 4212
47
Bexarotene Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 153559-49-0 82146
48
Azathioprine Approved Phase 4,Phase 3,Early Phase 1 446-86-6 2265
49
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 20830-81-3 30323
50
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 128794-94-5 5281078

Interventional clinical trials:

(show top 50) (show all 6915)
# Name Status NCT ID Phase Drugs
1 Use of Roflumilast to Prevent Exacerbations in Fibrotic Sarcoidosis Patients (REFS) Unknown status NCT01830959 Phase 4 Roflumilast;Placebo
2 Acthar Gel for Chronic Pulmonary Sarcoidosis (ACPS) Unknown status NCT02188017 Phase 4 Acthar gel
3 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
4 Low Grade Lymphoma Unknown status NCT01698866 Phase 4
5 Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients Unknown status NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
6 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
7 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
8 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
9 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
10 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
11 CEOP/IVE/GDP Compared With CEOP as the First-line Therapy for Newly Diagnosed Adult Patients With PTCL Unknown status NCT02533700 Phase 4 CEOP/IVE/GDP chemotherapy regimen;CEOP chemotherapy regimen for 6 cycles
12 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
13 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
14 Efficacy and Safety of Nipent, Cytoxan and Rituxan in the Treatment of Chronic Lymphocytic Leukemia. Unknown status NCT00131313 Phase 4 Nipent, Cytoxan, Rituxan
15 Optimization of the Primary Therapy for Patients With Hodgkin's Disease and Evaluation of PET Unknown status NCT00188149 Phase 4 Combined chemotherapy (ABVD, BACOPP-D)
16 CHUSPAN SCS BP Treatment of Churg–Strauss Syndrome Without Poor-Prognosis Factors Unknown status NCT00399399 Phase 4 azathioprine;cyclophosphamide
17 Effectiveness of Intracavitary Manual Lymphatic Drainage Completed NCT02960841 Phase 4
18 Comparison Between a Non-elastic Falcro Device and Current Method After Total Knee Arthroplasty Completed NCT02375945 Phase 4
19 A Comparison of Dermal Autograft to AlloDerm in Breast Reconstruction Completed NCT01561287 Phase 4
20 Short Term Effectiveness Study of Juxta-Fit Versus Trico Bandages in the Treatment of Leg Lymphedema Completed NCT01068431 Phase 4
21 A Study for Lymphocele and Lymphorrhea Control Following Inguinal and Axillary Radical Lymph Node Dissection Completed NCT02476357 Phase 4
22 Fludarabine, Cyclophosphamide, Doxorubicin and Rituximab for the Treatment of Post-transplant Lymphoproliferative Disease (PTLD) Completed NCT01088724 Phase 4 fludarabine, cyclophosphamide, doxorubicin, rituximab
23 A Study of the Quality of Life and Treatment Response to Once Weekly Epoetin Beta (Recormon) Treatment in Anemic Participants With Solid and Lymphoid Malignancies Completed NCT00776425 Phase 4 Epoetin beta
24 Use of Focalin for Fatigue in Sarcoidosis Completed NCT00361387 Phase 4 d-methylphenidate
25 Fractionated Versus Target-controlled Propofol Administration in Bronchoscopy Completed NCT02246023 Phase 4
26 Rasburicase for Treatment of Hyperuricemia in Children and Adolescence Patients With Tumor Lysis Syndrome Completed NCT00563771 Phase 4 Rasburicase
27 Rasburicase in Tumor Lysis Syndrome Completed NCT00302653 Phase 4 Rasburicase
28 Efficacy and Safety of Vivaglobin® in Previously Untreated Patients With Primary Immunodeficiency Completed NCT00520494 Phase 4 Vivaglobin
29 PEG-rhG-CSF in Patients With Lymphoma Receiving Chemotherapy Completed NCT02805218 Phase 4 PEG-rhG-CSF
30 An Expanded Access Program of Pegfilgrastim (Neulastim) in Participants With Non-Hodgkin's Lymphoma (NHL) Completed NCT02782845 Phase 4 Chemotherapy;Immunochemotherapy;Pegfilgrastim
31 Study of Combined Therapy of Aspirin and "IVIG-SN" in Kawasaki Disease Completed NCT01524939 Phase 4 immunoglobulin G
32 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
33 Evaluation of Approved Weight-Based Dose Compared to Fixed Dose of Plerixafor in Patients With Non-Hodgkin's Lymphoma (NHL) Weighing Less Than 70 Kilograms Completed NCT01164475 Phase 4 Granulocyte-colony stimulating factor (G-CSF);Fixed Dose Plerixafor;Weight-Based Plerixafor
34 Efficacy Response Duration and Toxicity of Rituximab, Fludarabine, and Cyclophosphamide (RFC) as 1st Line Treatment and Rituximab (R) in Maintenance Treatment in Follicular Non Hodgkin (FNH) Lymphoma Completed NCT01124526 Phase 4 Rituximab Fludarabine Cyclophosphamide
35 Doxorubicin Pharmacokinetics and Response in Non Hodgkin's Lymphoma Completed NCT00969462 Phase 4 Doxorubicin
36 Fasturtec TLS Treatment / Prophylysis Completed NCT00651911 Phase 4 urate oxidase
37 LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4 Prednisolone;Daunorubicin;Vincristine;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside
38 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin;Mercaptopurine;Prednisone;Vincristine;Methotrexate
39 MAXIMA Study: A Study of Maintenance Therapy With MabThera (Rituximab) in Patients With Non-Hodgkin's Lymphoma. Completed NCT00430352 Phase 4 rituximab [MabThera/Rituxan]
40 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
41 Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
42 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
43 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
44 Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
45 Zevalin® Followed by Rituxan® Maintenance in Previously Treated Low Grade Non-Hodgkin’s Lymphoma Completed NCT00168727 Phase 4 ibritumomab tiuxetan (Zevalin®)
46 Whole Brain Irradiation in Primary Central Nervous System (CNS) Lymphoma (PCNSL) Completed NCT00153530 Phase 4 methotrexate
47 Effect of Rituximab on Immunological Recall Response to Specific Antigens in the Treatment of Non-Hodgkin's Lymphoma Completed NCT00090038 Phase 4 rituximab
48 Inhaled Iloprost for Sarcoidosis-associated Pulmonary Hypertension Completed NCT00403650 Phase 4 Iloprost
49 Conventional Versus Ultrasound-guided Transbronchial Needle Aspiration for the Diagnosis of Hilar/Mediastinal Lymphadenopathies Completed NCT01658280 Phase 4
50 The Study on the Pharmacokinetics of PEG-rhG-CSF in Children and Adolescents Completed NCT02953730 Phase 4 PEG-rhG-CSF

Search NIH Clinical Center for Lymphatic System Disease

Cochrane evidence based reviews: lymphatic diseases

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Genetic Tests for Lymphatic System Disease

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Genetic tests related to Lymphatic System Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Lymphatic System 29
Sources

Anatomical Context for Lymphatic System Disease

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The Foundational Model of Anatomy Ontology organs/tissues related to Lymphatic System Disease:

19
The Lymphatic System

MalaCards organs/tissues related to Lymphatic System Disease:

41
B Cells, T Cells, Bone, Bone Marrow, Myeloid, Lung, Lymph Node
Sources

Publications for Lymphatic System Disease

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Articles related to Lymphatic System Disease:

# Title Authors Year
1
New developments in clinical aspects of lymphatic disease. ( 24590276 )
2014
2
Is tuberculosis a lymphatic disease with a pulmonary portal? ( 24268591 )
2013
3
Diffuse pulmonary lymphatic disease presenting as interstitial lung disease in adulthood: report of 3 cases. ( 22982897 )
2012
4
Klippel-TrAcnaunay syndrome: the importance of "geographic stains" in identifying lymphatic disease and risk of complications. ( 15337982 )
2004
5
Preclinical models of lymphatic disease: the potential for growth factor and gene therapy. ( 12543717 )
2002
6
Research perspectives in inherited lymphatic disease. ( 12543715 )
2002
7
The RA'le of the Lymphatics in Laryngeal Disease; and the RA'le of the Larynx in Lymphatic Disease. ( 19985030 )
1926
Sources

Variations for Lymphatic System Disease

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Expression for Lymphatic System Disease

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Search GEO for disease gene expression data for Lymphatic System Disease.
Sources

Pathways for Lymphatic System Disease

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Pathways related to Lymphatic System Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Lysosome 37
11.01 CD68 NPC1 NPC2 SMPD1
2
LDL Oxidation in Atherogenesis 64
10.46 CD68 SMPD1
3
VEGF ligand-receptor interactions 66
Show member pathways
 10.36 FLT4 VEGFC
4
Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF) 22
Show member pathways
 10.1 NPC1 NPC2
Sources

GO Terms for Lymphatic System Disease

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Cellular components related to Lymphatic System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 CD40LG FLT4 NPC1 NPC2 SMPD1 STXBP2
2 endosome GO:0005768 9.65 CD68 NPC1 SMPD1 TLR9 UNC13D
3 lysosome GO:0005764 9.02 NPC1 NPC2 SMPD1 TLR9 UNC13D
4 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.96 SDHB SDHD

Biological processes related to Lymphatic System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 exocytosis GO:0006887 9.5 STX11 STXBP2 UNC13D
2 lymph vessel development GO:0001945 9.26 FLT4 FOXC2
3 lymphangiogenesis GO:0001946 9.16 FLT4 FOXC2
4 regulation of mast cell degranulation GO:0043304 8.96 STXBP2 UNC13D
5 vascular endothelial growth factor receptor signaling pathway GO:0048010 8.8 FLT4 FOXC2 VEGFC

Molecular functions related to Lymphatic System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquinone binding GO:0048039 8.96 SDHB SDHD
2 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.62 SDHB SDHD
Sources

Sources for Lymphatic System Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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