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MCID: LYM024
MIFTS: 55

Lymphatic System Disease

Categories: Immune diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Lymphatic System Disease

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MalaCards integrated aliases for Lymphatic System Disease:

Name: Lymphatic System Disease 12 15 17
Lymphatic Diseases 44 45 74
Adenopathy 12 15
Disorder of Lymph Node and Lymphatics 12
Abnormality of the Lymphatic System 30
Disorder of Lymphatic System 12
Disorder of Lymphoid System 12
Disease of Lympoid System 12
Lympoid System Disease 12
Lymphatic Disorder 12
Lymphatic Disease 12
Lymphangiopathy 12

Classifications:

MalaCards categories:
Anatomical: Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:75
MeSH 45 D008206
SNOMED-CT 69 3305006
UMLS 74 C0024228
Sources

Summaries for Lymphatic System Disease

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MedlinePlus : 44 The lymphatic system is a network of tissues and organs. It is made up of Lymph - a fluid that contains white blood cells that defend against germs Lymph vessels - vessels that carry lymph throughout your body. They are different from blood vessels. Lymph nodes - glands found throughout the lymph vessels. Along with your spleen, these nodes are where white blood cells fight infection. Your bone marrow and thymus produce the cells in lymph. They are part of the system, too. The lymphatic system clears away infection and keeps your body fluids in balance. If it's not working properly, fluid builds in your tissues and causes swelling, called lymphedema. Other lymphatic system problems can include infections, blockage, and cancer.

MalaCards based summary : Lymphatic System Disease, also known as lymphatic diseases, is related to histiocytosis and hemophagocytic lymphohistiocytosis, and has symptoms including edema, axillary lymph node pain and axillary lymph node tenderness. An important gene associated with Lymphatic System Disease is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Tight junction and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. The drugs Prednisone and Azathioprine have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related phenotypes are no effect and hematopoietic system

Disease Ontology : 12 An immune system disease that is located in the lymphatic system.

Wikipedia : 77 Lymphatic disease is a class of disorders which directly affect the components of the lymphatic... more...

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Related Diseases for Lymphatic System Disease

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Diseases related to Lymphatic System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
# Related Disease Score Top Affiliating Genes
1 histiocytosis 31.9 CD1A CD207 SERPINA3 TNFRSF8
2 hemophagocytic lymphohistiocytosis 31.8 CD5 PRF1 STX11 STXBP2 UNC13D
3 periodic fever, aphthous stomatitis, pharyngitis and adenitis 11.8
4 pulmonary sarcoidosis 11.3
5 follicular lymphoma 11.1
6 systemic onset juvenile idiopathic arthritis 11.1
7 hennekam syndrome 11.0
8 lymphangitis 11.0
9 mycosis fungoides 11.0
10 hyper-igd syndrome 11.0
11 astrakhan spotted fever 11.0
12 indian tick typhus 11.0
13 israeli tick typhus 11.0
14 far eastern spotted fever 11.0
15 flinders island spotted fever 11.0
16 japanese spotted fever 11.0
17 mesenteric lymphadenitis 11.0
18 siberian tick typhus 11.0
19 boutonneuse fever 11.0
20 lymphadenitis 11.0
21 lymphatic malformation 1 10.9
22 yellow nail syndrome 10.9
23 lymphangiectasia, pulmonary, congenital 10.9
24 alk+ histiocytosis 10.5 CD1A CD207
25 middle ear carcinoma 10.5 CD1A SMUG1
26 good syndrome 10.5 STX11 UNC13D
27 langerhans cell sarcoma 10.5 CD1A CD207
28 nodular tenosynovitis 10.4 CD68 SERPINA3
29 hemangioma of spleen 10.4 FLT4 SMUG1
30 prostate lymphoma 10.4 CD5 SMUG1
31 breast lymphoma 10.4 CD5 SMUG1
32 congenital lymphedema 10.4 FLT4 FOXC2
33 hemophagocytic lymphohistiocytosis, familial, 4 10.4 STX11 STXBP2 UNC13D
34 inflammatory mfh 10.4 CD68 SERPINA3
35 pulmonary artery leiomyosarcoma 10.4 CD68 SMUG1
36 malignant epithelioid hemangioendothelioma 10.4 FLT4 SMUG1
37 multifocal motor neuropathy 10.4 CD1A CD1E
38 brain sarcoma 10.4 CD68 SMUG1
39 scrotal carcinoma 10.4 CD68 SERPINA3
40 macrophage activation syndrome 10.4 PRF1 UNC13D
41 dendritic cell tumor 10.4 CD1A CD207 CD68
42 xanthogranulomatous pyelonephritis 10.4 CD68 SERPINA3 SMUG1
43 xanthogranulomatous cholecystitis 10.3 CD68 SERPINA3 SMUG1
44 mediastinal cancer 10.3 CD5 SMUG1
45 eccrine adenocarcinoma 10.3 CD1C SMUG1
46 connective tissue cancer 10.3 CD68 SERPINA3 SMUG1
47 lactocele 10.3 CD68 SMUG1
48 conventional fibrosarcoma 10.3 CD68 TNFRSF8
49 lichen nitidus 10.3 CD68 TNFRSF8
50 adult lymphoma 10.3 CD5 SMUG1 TNFRSF8

Graphical network of the top 20 diseases related to Lymphatic System Disease:



Diseases related to Lymphatic System Disease
Sources

Symptoms & Phenotypes for Lymphatic System Disease

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UMLS symptoms related to Lymphatic System Disease:


edema, axillary lymph node pain, axillary lymph node tenderness

GenomeRNAi Phenotypes related to Lymphatic System Disease according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 CA8 CCR6 CD1A CD1B CD1C CD1D

MGI Mouse Phenotypes related to Lymphatic System Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 CCR6 CD1D CD207 CD5 CD68 PRF1
2 immune system MP:0005387 9.4 CCR6 CD1D CD207 CD5 CD68 FLT4
Sources

Drugs & Therapeutics for Lymphatic System Disease

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Drugs for Lymphatic System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1071)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
2
Azathioprine Approved Phase 4,Phase 3,Early Phase 1 446-86-6 2265
3
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1959-05-2, 59-05-2 126941
4
Azithromycin Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 83905-01-5 55185 447043
5
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 23214-92-8 31703
6
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 20830-81-3 30323
7
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
8
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 6006 143
9
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1177-87-3
10
Cytarabine Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 147-94-4, 65-46-3 6253
11
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
12
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 6055-19-2, 50-18-0 2907
13
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
14
Mercaptopurine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-44-2 667490
15
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 75607-67-9, 21679-14-1 30751
16
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
17
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
18
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 154-42-7 2723601
19
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2068-78-2, 57-22-7 5978
20
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 302962-49-8 3062316
21
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 33419-42-0 36462
22
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58957-92-9 42890
23
Riociguat Approved Phase 4 625115-55-1
24
Vinblastine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 865-21-4 13342 241903
25
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-23-7 5754
26
Teniposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 29767-20-2 34698
27
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 65271-80-9 4212
28
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-03-3
29
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 130167-69-0
30
Cladribine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 4291-63-8 20279
31
Vindesine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59917-39-4, 53643-48-4 40839
32
Sargramostim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 123774-72-1, 83869-56-1
33
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 174722-31-7 10201696
34
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 135968-09-1
35
Methylcobalamin Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1 13422-55-4
36
Ferrous succinate Approved Phase 4 10030-90-7
37
Iron Approved, Experimental Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 7439-89-6, 15438-31-0 23925 27284
38
Hydroxocobalamin Approved Phase 4,Phase 3,Phase 2,Phase 1 13422-51-0 11953898 15589840
39
Gemcitabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 95058-81-4 60750
40
Oxaliplatin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 61825-94-3 6857599 5310940 9887054 43805
41
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15663-27-1 441203 84093 2767
42
Epirubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 56420-45-2 41867
43
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 3778-73-2 3690
44
Entecavir Approved, Investigational Phase 4,Phase 2,Not Applicable 142217-69-4 153941
45
Pentostatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53910-25-1 40926 439693
46
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-61-7 60961
47
Vidarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 24356-66-9 21704 32326
48
Dopamine Approved Phase 4,Phase 1,Not Applicable 62-31-7, 51-61-6 681
49
Methylphenidate Approved, Investigational Phase 4,Not Applicable 113-45-1 4158
50
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-78-2 2244

Interventional clinical trials:

(show top 50) (show all 7367)
# Name Status NCT ID Phase Drugs
1 Use of Roflumilast to Prevent Exacerbations in Fibrotic Sarcoidosis Patients (REFS) Unknown status NCT01830959 Phase 4 Roflumilast;Placebo
2 Acthar Gel for Chronic Pulmonary Sarcoidosis (ACPS) Unknown status NCT02188017 Phase 4 Acthar gel
3 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
4 Low Grade Lymphoma Unknown status NCT01698866 Phase 4
5 PEG-rhG-CSF in Lymphoma Patients After Autologous Hematopoietic Stem Cell Transplantation Unknown status NCT02905942 Phase 4 PEG-rhG-CSF;rhG-CSF
6 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Unknown status NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
7 Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients Unknown status NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
8 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
9 Riociguat for Sarcoidosis Associated Pulmonary Hypertension Unknown status NCT02625558 Phase 4 Riociguat;Placebo
10 Surgery Alone, Surgery With Cyclophosphamide, Vinblastine, and Prednisolone (CVP), or CVP Alone in Treating Young Patients With Stage IA or Stage IIA Nodular Lymphocyte-Predominant Hodgkin Lymphoma Unknown status NCT01088750 Phase 4 cyclophosphamide;prednisolone;vinblastine sulfate
11 Treatment of High Risk Adult Acute Lymphoblastic Leukemia Unknown status NCT00853008 Phase 4 Vincristine;Daunorubicin;Prednisone;Mitoxantrone;Cytosine Arabinoside;Dexamethasone;Methotrexate (MTX);Cytarabine;ASP;Mercaptopurine;Teniposide;Hydrocortisone
12 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Unknown status NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
13 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
14 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
15 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
16 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
17 Erythropoietin in the Treatment of Anemia After Autologous Hematopoietic Stem Cell Transplantation Unknown status NCT03010579 Phase 4 erythropoietin;iron supplementation
18 PEG-rhG-CSF in Patients With Non-Hodgkin Lymphoma Receiving Chemotherapy to Prevent Neutropenia Unknown status NCT02996617 Phase 4 rhG-CSF regimen;Pegylated rhG-CSF regimen
19 To Compare the Efficacy of a Prophylactic Use of Tenofovir by Duration for the Non-Hodgkin's Lymphoma Unknown status NCT02585947 Phase 4 Tenofovir
20 CEOP/IVE/GDP Compared With CEOP as the First-line Therapy for Newly Diagnosed Adult Patients With PTCL Unknown status NCT02533700 Phase 4 CEOP/IVE/GDP chemotherapy regimen;CEOP chemotherapy regimen for 6 cycles
21 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
22 Treatment of Diffuse Large B Cell Lymphoma Unknown status NCT01949818 Phase 4 Yangzhengxiaoji capsule combined with CHOP regimen;CHOP regimen
23 Prophylactic Use of Entecavir for HBsAg Positive Lymphoma Patients Treated With Rituximab-based Immunochemotherapy Unknown status NCT01768195 Phase 4 Entecavir prophylaxis
24 Prophylactic Use of Entecavir for HBsAg Negative/HBcAb Positive/Hepatitis B Virus DNA Negative Patients With Lymphoma Unknown status NCT01765231 Phase 4 Entecavir prophylaxis;Observation arm
25 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
26 Efficacy and Safety of Nipent, Cytoxan and Rituxan in the Treatment of Chronic Lymphocytic Leukemia. Unknown status NCT00131313 Phase 4 Nipent, Cytoxan, Rituxan
27 Optimization of the Primary Therapy for Patients With Hodgkin's Disease and Evaluation of PET Unknown status NCT00188149 Phase 4 Combined chemotherapy (ABVD, BACOPP-D)
28 CHUSPAN SCS BP Treatment of Churg–Strauss Syndrome Without Poor-Prognosis Factors Unknown status NCT00399399 Phase 4 azathioprine;cyclophosphamide
29 Effectiveness of Intracavitary Manual Lymphatic Drainage Completed NCT02960841 Phase 4
30 Comparison Between a Non-elastic Falcro Device and Current Method After Total Knee Arthroplasty Completed NCT02375945 Phase 4
31 Lymphedema Study for Arm or Leg Lymphedema Completed NCT02257970 Phase 4 Ketoprofen;Placebo
32 A Comparison of Dermal Autograft to AlloDerm in Breast Reconstruction Completed NCT01561287 Phase 4
33 Short Term Effectiveness Study of Juxta-Fit Versus Trico Bandages in the Treatment of Leg Lymphedema Completed NCT01068431 Phase 4
34 A Study for Lymphocele and Lymphorrhea Control Following Inguinal and Axillary Radical Lymph Node Dissection Completed NCT02476357 Phase 4
35 Fludarabine, Cyclophosphamide, Doxorubicin and Rituximab for the Treatment of Post-transplant Lymphoproliferative Disease (PTLD) Completed NCT01088724 Phase 4 fludarabine, cyclophosphamide, doxorubicin, rituximab
36 A Study of the Quality of Life and Treatment Response to Once Weekly Epoetin Beta (Recormon) Treatment in Anemic Participants With Solid and Lymphoid Malignancies Completed NCT00776425 Phase 4 Epoetin beta
37 Use of Focalin for Fatigue in Sarcoidosis Completed NCT00361387 Phase 4 d-methylphenidate
38 OK432 (Picibanil) in the Treatment of Lymphatic Malformations Completed NCT03427619 Phase 4 OK432
39 Fractionated Versus Target-controlled Propofol Administration in Bronchoscopy Completed NCT02246023 Phase 4
40 Rasburicase for Treatment of Hyperuricemia in Children and Adolescence Patients With Tumor Lysis Syndrome Completed NCT00563771 Phase 4 Rasburicase
41 Rasburicase in Tumor Lysis Syndrome Completed NCT00302653 Phase 4 Rasburicase
42 Efficacy and Safety of Vivaglobin® in Previously Untreated Patients With Primary Immunodeficiency Completed NCT00520494 Phase 4 Vivaglobin
43 PEG-rhG-CSF in Patients With Lymphoma Receiving Chemotherapy Completed NCT02805218 Phase 4 PEG-rhG-CSF
44 An Expanded Access Program of Pegfilgrastim (Neulastim) in Participants With Non-Hodgkin's Lymphoma (NHL) Completed NCT02782845 Phase 4 Chemotherapy;Immunochemotherapy;Pegfilgrastim
45 Study of Combined Therapy of Aspirin and "IVIG-SN" in Kawasaki Disease Completed NCT01524939 Phase 4 immunoglobulin G
46 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
47 Comparison Of 2 Doses Of Temsirolimus (Torisel) In Patients With Mantle Cell Lymphoma Completed NCT01180049 Phase 4 temsirolimus;temsirolimus
48 Evaluation of Approved Weight-Based Dose Compared to Fixed Dose of Plerixafor in Patients With Non-Hodgkin's Lymphoma (NHL) Weighing Less Than 70 Kilograms Completed NCT01164475 Phase 4 Granulocyte-colony stimulating factor (G-CSF);Fixed Dose Plerixafor;Weight-Based Plerixafor
49 Efficacy Response Duration and Toxicity of Rituximab, Fludarabine, and Cyclophosphamide (RFC) as 1st Line Treatment and Rituximab (R) in Maintenance Treatment in Follicular Non Hodgkin (FNH) Lymphoma Completed NCT01124526 Phase 4 Rituximab Fludarabine Cyclophosphamide
50 Doxorubicin Pharmacokinetics and Response in Non Hodgkin's Lymphoma Completed NCT00969462 Phase 4 Doxorubicin

Search NIH Clinical Center for Lymphatic System Disease

Cochrane evidence based reviews: lymphatic diseases

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Genetic Tests for Lymphatic System Disease

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Genetic tests related to Lymphatic System Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Lymphatic System 30
Sources

Anatomical Context for Lymphatic System Disease

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MalaCards organs/tissues related to Lymphatic System Disease:

42
B Cells, T Cells, Bone, Breast, Bone Marrow, Myeloid, Lymph Node

The Foundational Model of Anatomy Ontology organs/tissues related to Lymphatic System Disease:

20
The Lymphatic System
Sources

Publications for Lymphatic System Disease

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Articles related to Lymphatic System Disease:

# Title Authors Year
1
Use of Unenhanced MR Lymphography to Characterize Lung Lymphatic Diseases. ( 28639922 )
2017
2
Reply to "Use of Unenhanced MR Lymphography to Characterize Lung Lymphatic Diseases". ( 28639923 )
2017
3
Imaging of thoracic lymphatic diseases. ( 19933641 )
2009
4
Lymphatic diseases. ( 1735059 )
1992
5
Heterochromatin and nucleolus organizer regions in cells of patients with malignant and premalignant lymphatic diseases. ( 6490006 )
1984
6
Skin and diabetes. III. Incidence of diabetes in a group of patients with skin disorders caused by venous and/or lymphatic diseases of the leg. ( 4470105 )
1974
7
CONGENITAL LYMPHATIC DISEASES-LYMPHANGIOMATA. ( 17857001 )
1937
Sources

Variations for Lymphatic System Disease

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Sources

Expression for Lymphatic System Disease

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Search GEO for disease gene expression data for Lymphatic System Disease.
Sources

Pathways for Lymphatic System Disease

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Pathways related to Lymphatic System Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Tight junction 38
11.78 CD1A CD1B CD1C CD1D CD1E
2
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 67
11.75 CD1A CD1B CD1C CD1D
3
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.61 CD1C CD5 CD68
4
Dendritic Cells Developmental Lineage Pathway 66
11.43 CD1A CD1C CD1D CD207
5
Hematopoietic cell lineage 38
11.09 CD1A CD1B CD1C CD1D CD1E CD5
6
B Cell Development Pathways 66
10.98 CD1C CD1D CD5 TNFRSF8
Sources

GO Terms for Lymphatic System Disease

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Cellular components related to Lymphatic System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.98 CCR6 CD1A CD1C CD1D CD1E CD5
2 cell surface GO:0009986 9.8 CCR6 CD1A CD1B CD1C CD1D CD1E
3 lysosome GO:0005764 9.77 CD1B CD1C CD1D CD1E UNC13D
4 cytolytic granule GO:0044194 9.4 PRF1 STXBP2
5 endosome membrane GO:0010008 9.35 CD1A CD1B CD1C CD1D CD68
6 endosome GO:0005768 9.23 CD1A CD1B CD1C CD1D CD1E CD68
7 membrane GO:0016020 10.33 CCR6 CD1A CD1B CD1C CD1D CD1E
8 integral component of membrane GO:0016021 10.1 CCR6 CD1A CD1B CD1C CD1D CD1E
9 plasma membrane GO:0005886 10 CCR6 CD1A CD1B CD1C CD1D CD1E

Biological processes related to Lymphatic System Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.88 CD1A CD1B CD1C CD1D CD1E
2 adaptive immune response GO:0002250 9.76 CD1A CD1B CD1C CD1E
3 immune response GO:0006955 9.73 CCR6 CD1A CD1B CD1C CD1D CD1E
4 exocytosis GO:0006887 9.67 STX11 STXBP2 UNC13D
5 regulation of immune response GO:0050776 9.62 CD1A CD1B CD1C CD1D
6 positive regulation of T cell mediated cytotoxicity GO:0001916 9.55 CD1A CD1B CD1C CD1D CD1E
7 lymph vessel development GO:0001945 9.43 FLT4 FOXC2
8 lymphangiogenesis GO:0001946 9.4 FLT4 FOXC2
9 regulation of mast cell degranulation GO:0043304 9.37 STXBP2 UNC13D
10 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.35 CD1A CD1B CD1C CD1D CD1E
11 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1A CD1B CD1C CD1D CD1E

Molecular functions related to Lymphatic System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.55 CD1A CD1B CD1C CD1D CD1E
2 endogenous lipid antigen binding GO:0030883 9.35 CD1A CD1B CD1C CD1D CD1E
3 exogenous lipid antigen binding GO:0030884 9.02 CD1A CD1B CD1C CD1D CD1E
Sources

Sources for Lymphatic System Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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