MCID: LYM025
MIFTS: 55

Lymphedema

Categories: Blood diseases, Cancer diseases, Fetal diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Neuronal diseases, Oral diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Lymphedema

MalaCards integrated aliases for Lymphedema:

Name: Lymphedema 38 76 29 55 43 3 40 73

Classifications:



External Ids:

UMLS 73 C0024236

Summaries for Lymphedema

MedlinePlus : 43 Lymphedema is the name of a type of swelling. It happens when lymph builds up in your body's soft tissues. Lymph is a fluid that contains white blood cells that defend against germs. It can build up when the lymph system is damaged or blocked. It usually happens in the arms or legs. Causes of lymphedema include Infection Cancer Scar tissue from radiation therapy or surgical removal of lymph nodes Inherited conditions in which lymph nodes or vessels are absent or abnormal Treatment can help control symptoms. It includes exercise, compression devices, skin care, and massage. NIH: National Cancer Institute

MalaCards based summary : Lymphedema is related to hereditary lymphedema i and lymphedema, hereditary, ii, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Lymphedema is FLT4 (Fms Related Tyrosine Kinase 4), and among its related pathways/superpathways are VEGF Pathway (Qiagen) and Heart Development. The drugs Mekinist and Ketoprofen have been mentioned in the context of this disorder. Affiliated tissues include Heart, breast and lymph node, and related phenotypes are Decreased viability in esophageal squamous lineage and homeostasis/metabolism

CDC : 3 People with the disease can suffer from lymphedema and elephantiasis and in men, swelling of the scrotum, called hydrocele. Lymphatic filariasis is a leading cause of permanent disability worldwide. Communities frequently shun and reject women and men disfigured by the disease. Affected people frequently are unable to work because of their disability, and this harms their families and their communities.

Wikipedia : 76 Lymphedema, also known as lymphoedema and lymphatic edema, is a condition of localized fluid retention... more...

Related Diseases for Lymphedema

Diseases in the Lymphedema family:

Lymphedema, Hereditary, Ia Lymphedema, Hereditary, Ii
Lymphedema, Congenital Recessive Lymphedema, Hereditary, Ib
Lymphedema, Hereditary, Ic Lymphedema, Hereditary, Id
Lymphedema, Hereditary, Iii Hereditary Lymphedema
Hereditary Lymphedema I Congenital Lymphedema

Diseases related to Lymphedema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 275)
# Related Disease Score Top Affiliating Genes
1 hereditary lymphedema i 33.8 FLT4 SOX18
2 lymphedema, hereditary, ii 33.7 FOXC2 SOX18
3 yellow nail syndrome 33.2 FOXC2 SOX18
4 hereditary lymphedema 33.1 FLT4 FOXC2 SOX18 VEGFC
5 hennekam syndrome 32.9 CCBE1 FLT4 VEGFC
6 congenital lymphedema 32.6 FLT4 FOXC2 KIF11 VEGFC
7 lymphangiosarcoma 32.6 FLT4 VEGFC
8 lymphatic system disease 30.9 CCBE1 FLT4 FOXC2 VEGFC
9 gorham's disease 29.6 FLT4 VEGFC
10 klippel-trenaunay-weber syndrome 29.6 FLT4 FOXC2 SOX18
11 lymphedema-distichiasis syndrome 12.7
12 lymphedema, hereditary, ia 12.6
13 microcephaly with or without chorioretinopathy, lymphedema, or mental retardation 12.6
14 hypotrichosis-lymphedema-telangiectasia syndrome 12.5
15 hennekam lymphangiectasia-lymphedema syndrome 1 12.5
16 cholestasis-lymphedema syndrome 12.5
17 lymphedema, primary, with myelodysplasia 12.4
18 choanal atresia and lymphedema 12.4
19 lymphedema, hereditary, ic 12.4
20 lymphedema, hereditary, iii 12.4
21 lymphedema, hereditary, id 12.4
22 hennekam lymphangiectasia-lymphedema syndrome 2 12.3
23 ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis, and lymphedema 12.3
24 deafness-lymphedema-leukemia syndrome 12.3
25 hennekam lymphangiectasia-lymphedema syndrome 3 12.3
26 lymphedema, hereditary, ib 12.3
27 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 12.2
28 lymphedema, cardiac septal defects, and characteristic facies 12.2
29 agenesis of the corpus callosum and congenital lymphedema 12.1
30 lymphedema and cerebral arteriovenous anomaly 12.0
31 lymphedema-hypoparathyroidism syndrome 12.0
32 lymphedema, congenital recessive 11.9
33 dahlberg borer newcomer syndrome 11.7
34 takenouchi-kosaki syndrome 11.6
35 filarial elephantiasis 11.5
36 elephantiasis 11.3
37 kaposi sarcoma 11.3
38 podoconiosis 11.2
39 turner syndrome 11.2
40 oculodentodigital dysplasia 11.2
41 immunodeficiency 21 11.2
42 bier spots 11.2
43 irons bhan syndrome 11.1
44 microcephaly and chorioretinopathy, autosomal recessive, 1 10.9
45 immunodeficiency 33 10.9
46 cerebellar ataxia, deafness, and narcolepsy, autosomal dominant 10.9
47 phelan-mcdermid syndrome 10.9
48 kanzaki disease 10.9
49 poikiloderma, hereditary fibrosing, with tendon contractures, myopathy, and pulmonary fibrosis 10.9
50 verruciform xanthoma of skin 10.9

Graphical network of the top 20 diseases related to Lymphedema:



Diseases related to Lymphedema

Symptoms & Phenotypes for Lymphedema

UMLS symptoms related to Lymphedema:


angina pectoris, edema, chest pain, peau d'orange

GenomeRNAi Phenotypes related to Lymphedema according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.1 CCBE1 FLT4 FOXC2 GATA2 KIF11 SOX18

MGI Mouse Phenotypes related to Lymphedema:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.87 CCBE1 FLT4 FOXC2 GATA2 IKBKG SOX18
2 cardiovascular system MP:0005385 9.85 FLT4 FOXC2 GATA2 IKBKG SOX18 VEGFC
3 immune system MP:0005387 9.8 CCBE1 FLT4 FOXC2 GJC2 IKBKG SOX18
4 adipose tissue MP:0005375 9.71 FLT4 FOXC2 IKBKG SOX18
5 mortality/aging MP:0010768 9.61 CCBE1 FLT4 FOXC2 GATA2 GJC2 IKBKG
6 liver/biliary system MP:0005370 9.55 CCBE1 FLT4 FOXC2 GATA2 IKBKG
7 normal MP:0002873 9.17 CCBE1 FLT4 FOXC2 GATA2 GJC2 IKBKG

Drugs & Therapeutics for Lymphedema

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Mekinist 18 49 TRAMETINIB DIMETHYL SULFOXIDE GlaxoSmithKline May of 2013

Drugs for Lymphedema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 167)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketoprofen Approved, Vet_approved Phase 4,Not Applicable 22071-15-4 3825
2
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
3
Ivermectin Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 70288-86-7 6474909
4
Albendazole Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 54965-21-8 2082
5
Azithromycin Approved Phase 4,Phase 3,Phase 2,Not Applicable 83905-01-5 55185 447043
6 Radiopharmaceuticals Phase 4,Phase 2,Early Phase 1,Not Applicable
7 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
8 Anti-Inflammatory Agents Phase 4,Not Applicable
9 Cyclooxygenase Inhibitors Phase 4,Not Applicable
10 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Not Applicable
11 Analgesics Phase 4,Not Applicable
12 Antirheumatic Agents Phase 4,Not Applicable
13 Analgesics, Non-Narcotic Phase 4,Not Applicable
14 penicillins Phase 4
15 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Not Applicable
16 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
17 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
18 Coagulants Phase 4,Phase 3,Not Applicable
19 Fibrin Tissue Adhesive Phase 4,Phase 3,Not Applicable
20 Hemostatics Phase 4,Phase 3,Not Applicable
21 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
22 Antimitotic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
23 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
24 Anthelmintics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
25
Petrolatum Approved, Investigational Phase 3 8009-03-8
26
Glycerol Approved, Investigational Phase 3 56-81-5 753
27
Doxycycline Approved, Investigational, Vet_approved Phase 3,Phase 2 564-25-0 54671203
28
Ropivacaine Approved Phase 3,Not Applicable 84057-95-4 175805 71273
29
Diethylcarbamazine Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 90-89-1 3052
30
Clarithromycin Approved Phase 2, Phase 3 81103-11-9 84029
31
Streptomycin Approved, Vet_approved Phase 2, Phase 3 57-92-1 19649
32
Rifampicin Approved Phase 2, Phase 3 13292-46-1 5458213 5381226
33 Anesthetics Phase 3,Not Applicable
34 Anesthetics, Local Phase 3,Not Applicable
35 Eusol Phase 3
36 Protective Agents Phase 3,Phase 2
37 Sodium hypochlorite Phase 3
38 Disinfectants Phase 3
39 Antimalarials Phase 3,Phase 2
40 Central Nervous System Depressants Phase 3,Not Applicable
41 Lipoxygenase Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
42 Pharmaceutical Solutions Phase 3,Phase 2,Not Applicable
43 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
44 Cytochrome P-450 CYP3A Inducers Phase 2, Phase 3
45 Antitubercular Agents Phase 2, Phase 3
46 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
47 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
48
Selenious acid Approved, Investigational Phase 2 7783-00-8
49
Selenium Approved, Investigational, Vet_approved Phase 2 7782-49-2
50
Pentoxifylline Approved, Investigational Phase 2 6493-05-6 4740

Interventional clinical trials:

(show top 50) (show all 392)
# Name Status NCT ID Phase Drugs
1 Lymphedema Study for Arm or Leg Lymphedema Completed NCT02257970 Phase 4 Ketoprofen;Placebo
2 Short Term Effectiveness Study of Juxta-Fit Versus Trico Bandages in the Treatment of Leg Lymphedema Completed NCT01068431 Phase 4
3 Low Level Laser Treatment and Breast Cancer Related Lymphedema Completed NCT00852930 Phase 4
4 Comparison Between a Non-elastic Falcro Device and Current Method After Total Knee Arthroplasty Completed NCT02375945 Phase 4
5 A Comparison of Dermal Autograft to AlloDerm in Breast Reconstruction Completed NCT01561287 Phase 4
6 A Study for Lymphocele and Lymphorrhea Control Following Inguinal and Axillary Radical Lymph Node Dissection Completed NCT02476357 Phase 4
7 RCT to Investigate if Prophylactic Antibiotics Prevent Further Episodes of Cellulitis (Erysipelas) of the Leg Completed NCT00552799 Phase 4 Penicillin VK
8 Post-Operative Drainage Following Lymph Node Dissection Completed NCT00324272 Phase 4 Fibrin Sealant (Tisseel) used in the Experimental Arm.
9 Impact of Albendazole -Ivermectin on Wuchereria Bancrofti in Mali Completed NCT02784743 Phase 4 ''albendazole'' and ''ivermectin''
10 Twice Yearly Treatment for the Control of LF Recruiting NCT03036059 Phase 4 400 μg/kg Ivermectin + 400 mg Albendazole
11 Lower-Limb Drainage Mapping in Pelvic Lymphadenectomy for Gynaecological Cancer Active, not recruiting NCT01946672 Phase 4
12 Effect of Exercise on Indocyanine Green (ICG) Lymphography Imaging Not yet recruiting NCT03584633 Phase 4 Indocyanine Green
13 Cluster RCT of Co-administration Azithromycin, Albendazole & Ivermectin Not yet recruiting NCT03570814 Phase 4 Administration of Albendazole on Day 1;Administration of Ivermectin on Day 1;Administration of Azithromycin on Day 1;Administration of Azithromycin on Day 15
14 Pulsed Electromagnetic Fields (PEMF) and Post-Axillary Surgery Morbidity Terminated NCT01255631 Phase 4
15 Flexitouch Compression System for Venous Stasis Ulcer Terminated NCT00534937 Phase 4
16 Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis Withdrawn NCT01903057 Phase 4 azithromycin;ivermectin;albendazole;placebo
17 Treatment Trial for Post-Thrombotic Syndrome Unknown status NCT00633971 Phase 3
18 Prevention of Pelvic Lymphocele by Floseal During Pelvic Lymphadenectomy for Gynecologic Cancer Unknown status NCT01974193 Phase 3 Floseal
19 Randomized Trial of Exercise on Lower Extremity Edema After Lymphadenectomy in Gynecologic Cancer Unknown status NCT01849224 Phase 3
20 Lymphedema Upper Limb of Breast Cancer Through Muscle Strengthening Associated With Complex Physical Therapy Completed NCT02574780 Phase 2, Phase 3
21 Fibrin Sealant in Decreasing Lymphedema Following Surgery to Remove Lymph Nodes in Patients With Cancer of the Vulva Completed NCT00028951 Phase 3 fibrin sealant
22 Trial of Decongestive Lymphatic Therapy for Lymphedema in Women With Breast Cancer "DELTA STUDY" Completed NCT00201890 Phase 3
23 Does Scar Massage Improve Postoperative Pain and Function in Women With Breast Cancer? Completed NCT00175344 Phase 3
24 Immediate Radiotherapy or Observation After Surgery for Melanoma Involving Lymph Nodes Completed NCT00287196 Phase 3
25 Effects of Aerobic Exercise Versus Weight Training in Breast Cancer Survivors During Chemotherapy Completed NCT00115713 Phase 3
26 Effect of the LIVESTRONG at the YMCA Exercise Program on Cancer Related Outcomes in Cancer Survivors Completed NCT02112149 Phase 3
27 An RCT to Evaluate the Effect of a New Skin Care Regimen on SBF in Those With Podoconiosis Completed NCT02839772 Phase 3
28 Repeat Ivermectin Mass Drug Administrations for Control of Malaria: a Pilot Safety and Efficacy Study Completed NCT02509481 Phase 2, Phase 3 Ivermectin;Albendazole
29 A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali Recruiting NCT02927496 Phase 3 Doxycycline;Placebo
30 Treatment of Breast Cancer-related Lymphedema With Stem Cells and Fat Grafting Recruiting NCT03776721 Phase 3
31 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka Recruiting NCT02929134 Phase 3 Doxycycline;Placebo
32 Pre-existing Factors, Early Detection and Early Treatment of Breast Cancer Related Lymphedema Recruiting NCT03210311 Phase 3
33 Conventional Versus Hypofractionated Radiotherapy in Node Positive Breast Cancer Recruiting NCT02690636 Phase 3
34 Breast Cancer Rehabilitation With Acupuncture and Physical Therapy Protocol Recruiting NCT02798263 Phase 2, Phase 3
35 Evaluation of Groin Lymphadenectomy Extent For Metastatic Melanoma Recruiting NCT02166788 Phase 3
36 Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer Recruiting NCT03414970 Phase 3
37 Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy Recruiting NCT01901094 Phase 3
38 Regional Radiotherapy in Biomarker Low Risk Node Positive Breast Cancer Recruiting NCT03488693 Phase 3
39 Education With or Without Exercise and Counseling in Preventing Lymphedema in Women With Stage I, Stage II, or Stage III Breast Cancer Who Are Undergoing Axillary Lymph Node Dissection Active, not recruiting NCT00376597 Phase 3
40 MIRs03: Paravertebral Block With Ropivacaine Before Breast Cancer Surgery Active, not recruiting NCT02408393 Phase 3 Saline;Ropivacaine
41 WHO Drug Study for Buruli Ulcer - Comparison of SR8 and CR8 Active, not recruiting NCT01659437 Phase 2, Phase 3 Clarithromycin Extended Release;Streptomycin intramuscular injection
42 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India Not yet recruiting NCT02929121 Phase 3 Doxycycline;Placebo
43 Immunonutrition and Carbohydrate Loading Strategies in Breast Reconstruction Not yet recruiting NCT03764943 Phase 3
44 Safety of Co-administration of IDA and Azithromycin for NTDs ( ComboNTDs ) Not yet recruiting NCT03676140 Phase 3 Albendazole on Day 1;Ivermectin on Day 1;Diethylcarbamazine on day 1;Azithromycin on Day 1;Azithromycin on Day 8
45 Flexitouch® Home Maintenance Therapy or Standard Home Maintenance Therapy in Treating Patients With Lower-Extremity Lymphedema Caused by Treatment for Cervical Cancer, Vulvar Cancer, or Endometrial Cancer Terminated NCT00577317 Phase 3
46 Fat Grafting Used for the Treatment of Breast Cancer Related Lymphedema in China Unknown status NCT02981485 Phase 2
47 Treatment of Breast Cancer Related Lymphedema With Cell-assisted Lipotransfer Unknown status NCT02592213 Phase 2
48 Treatment of Lymphedema: Application of the Kinesio Taping Unknown status NCT00155220 Phase 2
49 Hyperbaric Oxygen Therapy Compared With Standard Therapy in Treating Chronic Arm Lymphedema in Patients Who Have Undergone Radiation Therapy for Cancer Unknown status NCT00077090 Phase 2 hyperbaric oxygen
50 Therapeutical Assessment of Compression Armsleeves for Lymphatic Indications Unknown status NCT01318785 Phase 2

Search NIH Clinical Center for Lymphedema

Genetic Tests for Lymphedema

Genetic tests related to Lymphedema:

# Genetic test Affiliating Genes
1 Lymphedema 29

Anatomical Context for Lymphedema

MalaCards organs/tissues related to Lymphedema:

41
Breast, Lymph Node, Skin, Endothelial, Testes, Heart, Myeloid
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Lymphedema:
# Tissue Anatomical CompartmentCell Relevance
1 Heart Cardinal Veins Venous Endothelial Cells Affected by disease, potential therapeutic candidate

Publications for Lymphedema

Articles related to Lymphedema:

(show top 50) (show all 1846)
# Title Authors Year
1
Non-contrast Magnetic Resonance Lymphangiography: an emerging technique for the study of lymphedema. ( 30340075 )
2019
2
Evaluation of patency rates of different lymphaticovenous anastomosis techniques and risk factors for obstruction in secondary upper extremity lymphedema. ( 30442581 )
2019
3
Correction to: "Effects of Aqua-Lymphatic Therapy on Lower Extremity Lymphedema: A Randomized Controlled Study" by G Ergin, D Karadibak, HO Sener, and B Gurpinar Lymphatic Research and Biology 2017; 15(3): 284-291 DOI: 10.1089/lrb.2017.0017. ( 29432065 )
2018
4
A lymphedema surveillance program for breast cancer patients reveals the promise of surgical prevention. ( 29397949 )
2018
5
Head and neck lymphedema management: Evaluation of a therapy program. ( 29385298 )
2018
6
Vectra 3D Imaging for Suprapubic Lymphedema and Volume Change of the Lower Abdomen Associated with Lower Extremity Lymphedema. ( 29381554 )
2018
7
Donor-Site Lymphedema Following Lymph Node Transfer for Breast Cancer-Related Lymphedema: A Systematic Review of the Literature. ( 29087763 )
2018
8
Indocyanine green lymphography for diagnosis of lymphedema following thigh lift surgery. ( 29921015 )
2018
9
Hand Edema in Patients at Risk of Breast Cancer-Related Lymphedema (BCRL): Health Professionals Should Take Notice. ( 29361079 )
2018
10
Lymphedema symptoms and limb measurement changes in breast cancer survivors treated with neoadjuvant chemotherapy and axillary dissection: results of American College of Surgeons Oncology Group (ACOSOG) Z1071 (Alliance) substudy. ( 29980907 )
2018
11
A rare symptom of a very rare disease: a case report of a oculodentodigital dysplasia with lymphedema. ( 29624507 )
2018
12
Primary Congenital Lymphedema. ( 29762243 )
2018
13
Supplementation with RobuvitAr in post-mastectomy post-radiation arm lymphedema. ( 29911794 )
2018
14
Further delineation of the SOX18-related Hypotrichosis, Lymphedema, Telangiectasia syndrome (HTLS). ( 29307792 )
2018
15
Primary lymphedema and other lymphatic anomalies are associated with 22q11.2 deletion syndrome. ( 29447908 )
2018
16
Lymphedema secondary to limited cutaneous systemic sclerosis. ( 29909388 )
2018
17
Quality of Life Questionnaires in Breast Cancer-Related Lymphedema Patients: Review of the Literature. ( 29437542 )
2018
18
Warty Fingers and Toes in a Child With Congenital Lymphedema: Elephantiasis Nostras Verrucosa. ( 29710245 )
2018
19
Changes in volume and incidence of lymphedema during and after treatment with docetaxel, doxorubicin, and cyclophosphamide (TAC) in patients with breast cancer. ( 29127528 )
2018
20
Lymphedema-Distichiasis Syndrome in a Male Patient Followed for 16 Years. ( 29342028 )
2018
21
Preoperative Lymphedema-Related Risk Factors in Early-Stage Breast Cancer. ( 28346852 )
2018
22
Lymphedema surgery: the current state of the art. ( 29980891 )
2018
23
Lymphedema in ovarian cancer survivors: Assessing diagnostic methods and the effects of physical activity. ( 29437202 )
2018
24
The Effect of Exercise on Breast Cancer-Related Lymphedema: What the Lymphatic Surgeon Needs to Know. ( 29935493 )
2018
25
Validation of a short form FLQA-LS quality of life instrument for lymphedema. ( 29927481 )
2018
26
Improvement of the efficacy of vascularized lymph node transfer for lower-extremity lymphedema via a prefabricated lympho-venous shunt through lymphaticovenular anastomosis between the efferent lymphatic vessel and small vein in the elevated vascularized lymph node. ( 28877360 )
2018
27
Preventing Breast Cancer-Related Lymphedema in High-Risk Patients: The Impact of a Structured Surveillance Protocol Using Bioimpedance Spectroscopy. ( 29946531 )
2018
28
A quantitative evaluation with an innovative wireless bio-impedance device to check improvement of limb lymphedema after receiving two-site vascularized lymph node transfer simultaneously in a patient. ( 29446479 )
2018
29
Diagnosis and Treatment of Edema and Lymphedema in the Cancer Patient. ( 29957700 )
2018
30
Association between extremity kaposiform hemangioendothelioma and lymphedema. ( 29266383 )
2018
31
Clinical effectiveness of decongestive treatments on excess arm volume and patient-centered outcomes in women with early breast cancer-related arm lymphedema: a systematic review. ( 29419623 )
2018
32
Correlation Between Changes in Extremity Volume and Bioelectrical Impedance in Arm and Leg Lymphedema. ( 29356595 )
2018
33
Genetic tests in lymphatic vascular malformations and lymphedema. ( 29440349 )
2018
34
Novel FOXC2 Mutation and Distichiasis in a Patient With Lymphedema-Distichiasis Syndrome. ( 29406328 )
2018
35
Psychometric evaluation of the Persian version of the Lymphedema Life Impact Scale (LLIS, version 1) in breast cancer patients. ( 29954381 )
2018
36
Mapping the geographical distribution of podoconiosis in Cameroon using parasitological, serological, and clinical evidence to exclude other causes of lymphedema. ( 29324858 )
2018
37
Incidence of Cellulitis among Children with Primary Lymphedema. ( 29791815 )
2018
38
Function, Shoulder Motion, Pain, and Lymphedema in Breast Cancer With and Without Axillary Web Syndrome: An 18-Month Follow-Up. ( 29361075 )
2018
39
Visualization of lymphatic ducts with preoperative ICG lymphography prevents donor-site lymphedema following PAP flap. ( 29936003 )
2018
40
Reply to Letter to the Editor "Vectra 3D Imaging for Quantitative Volumetric Analysis of the Upper Limb: A Feasibility Study for Tracking Outcomes of Lymphedema Treatment". ( 29381551 )
2018
41
US budget impact of increased payer adoption of the Flexitouch advanced pneumatic compression device in lymphedema patients with advanced chronic venous insufficiency and multiple infections. ( 29975564 )
2018
42
The Effectiveness of the Sport "Dragon Boat Racing" in Reducing the Risk of Lymphedema Incidence: An Observational Study. ( 29933309 )
2018
43
Stem Cell Therapy Using Bone Marrow-Derived Mononuclear Cells in Treatment of Lower Limb Lymphedema: A Randomized Controlled Clinical Trial. ( 29912663 )
2018
44
The Effect of Lymphaticovenous Anastomosis in Breast Cancer-Related Lymphedema: A Review of the Literature. ( 29356596 )
2018
45
Prospective Experimental Study of Microvascular Reconstruction in Lymphedema. ( 29912665 )
2018
46
Reply to comment on: Ileocecal vascularized lymph node transfer for the treatment of extremity lymphedema: A case report. ( 29974502 )
2018
47
Delayed Breast Reconstruction on Patients With Upper Extremity Lymphedema: A Systematic Review of the Literature and Pooled Analysis. ( 29944525 )
2018
48
Disseminated Mycobacterium marinum skin infection due to chronic lymphedema in an immunocompetent patient. ( 29603601 )
2018
49
Machine learning for detection of lymphedema among breast cancer survivors. ( 29963562 )
2018
50
Comparison of long-term clinical outcomes among different vascularized lymph node transfers: 6-year experience of a single center's approach to the treatment of lymphedema. ( 29357118 )
2018

Variations for Lymphedema

Expression for Lymphedema

Search GEO for disease gene expression data for Lymphedema.

Pathways for Lymphedema

GO Terms for Lymphedema

Cellular components related to Lymphedema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitotic spindle GO:0072686 8.62 IKBKG KIF11

Biological processes related to Lymphedema according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.8 FLT4 FOXC2 GATA2 SOX18 VEGFC
2 heart development GO:0007507 9.72 FOXC2 GATA2 SOX18
3 angiogenesis GO:0001525 9.71 FLT4 SOX18 VEGFC
4 positive regulation of angiogenesis GO:0045766 9.65 CCBE1 GATA2 VEGFC
5 positive regulation of endothelial cell proliferation GO:0001938 9.59 FLT4 VEGFC
6 blood vessel development GO:0001568 9.58 FOXC2 SOX18
7 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.58 FOXC2 GATA2
8 cell maturation GO:0048469 9.57 GATA2 SOX18
9 respiratory gaseous exchange GO:0007585 9.56 CCBE1 FLT4
10 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.54 FLT4 FOXC2 VEGFC
11 positive regulation of vascular endothelial growth factor production GO:0010575 9.52 CCBE1 FLT4
12 vasculature development GO:0001944 9.51 FLT4 SOX18
13 positive regulation of endothelial cell migration GO:0010595 9.5 CCBE1 FLT4 FOXC2
14 embryonic heart tube development GO:0035050 9.49 FOXC2 SOX18
15 vascular endothelial growth factor signaling pathway GO:0038084 9.46 FLT4 VEGFC
16 respiratory system process GO:0003016 9.43 CCBE1 FLT4
17 sprouting angiogenesis GO:0002040 9.33 CCBE1 FLT4 VEGFC
18 positive regulation of lymphangiogenesis GO:1901492 9.26 CCBE1 VEGFC
19 lymph vessel development GO:0001945 9.26 CCBE1 FLT4 FOXC2 SOX18
20 lymphangiogenesis GO:0001946 8.92 CCBE1 FLT4 FOXC2 SOX18

Sources for Lymphedema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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