MCID: LYM026
MIFTS: 64

Lymphoblastic Leukemia

Categories: Cancer diseases, Immune diseases, Blood diseases, Rare diseases, Genetic diseases

Aliases & Classifications for Lymphoblastic Leukemia

MalaCards integrated aliases for Lymphoblastic Leukemia:

Name: Lymphoblastic Leukemia 12 15
Precursor Cell Lymphoblastic Leukemia Lymphoma 73
Acute Lymphocytic Leukemia 73
Leukemia, Lymphoid 44
Lymphoid Leukemia 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1037
ICD10 33 C91 C91.9 C91.90
ICD9CM 35 204 204.9
MeSH 44 D007945
NCIt 50 C7539

Summaries for Lymphoblastic Leukemia

Disease Ontology : 12 A leukemia that has material basis in lymphoblasts (immature white blood cells).

MalaCards based summary : Lymphoblastic Leukemia, also known as precursor cell lymphoblastic leukemia lymphoma, is related to b-cell childhood acute lymphoblastic leukemia and leukemia, acute lymphoblastic, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Lymphoblastic Leukemia is DLEU2 (Deleted In Lymphocytic Leukemia 2
Dleu2 is an antisense transcript that encompasses the Kcnrg and Trim13 genes,as well as two microRNA genes,Mirn16-1 and Mirn15a,which have been previously identified in lymphocytic leukemia.
Dysfunction Pattern: Locus), and among its related pathways/superpathways are Pathways in cancer and NF-kappaB Signaling. The drugs Arranon and Blincyto have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related phenotypes are cellular and hematopoietic system

Related Diseases for Lymphoblastic Leukemia

Diseases in the Lymphoblastic Leukemia family:

Leukemia, Acute Lymphoblastic Leukemia, Acute Lymphoblastic 2
Leukemia, Acute Lymphoblastic 3

Diseases related to Lymphoblastic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 456)
# Related Disease Score Top Affiliating Genes
1 b-cell childhood acute lymphoblastic leukemia 34.9 ETV6 IKZF1 RUNX1
2 leukemia, acute lymphoblastic 34.7 ABL1 ETV6 FLT3 NBN RUNX1
3 lymphoblastic leukemia, acute, with lymphomatous features 34.3 ABL1 CRLF2 JAK2 NT5C2
4 precursor t-cell acute lymphoblastic leukemia 34.1 ABL1 ETV6 FLT3 IKZF1 LMO2 LYL1
5 acute lymphocytic leukemia 33.8 ETV6 NOTCH1 RUNX1 TAL2
6 b-cell adult acute lymphocytic leukemia 33.7 ABL1 IKZF1 PBX1
7 leukemia, acute lymphoblastic 3 33.2 ABL1 ETV6 FLT3 IKZF1 PBX1 RUNX1
8 lymphoid leukemia 32.7 ETV6 FLT3 JAK2 NBN
9 leukemia, acute myeloid 32.1 ABL1 ETV6 FLT3 HOTAIR JAK2 RUNX1
10 childhood leukemia 31.5 ABL1 ETV6 PBX1 RUNX1 TCF3
11 acute leukemia 31.4 ETV6 FLT3 JAK2 RUNX1 TCF3
12 leukemia 31.4 ABL1 ETV6 FLT3 HOTAIR JAK2 LYL1
13 myeloid leukemia 31.4 ABL1 ETV6 FLT3 JAK2 RUNX1
14 chronic myelomonocytic leukemia 31.0 ETV6 FLT3 JAK2 RUNX1
15 myelodysplastic syndrome 30.8 ABL1 ETV6 FLT3 JAK2 RUNX1
16 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 30.7 ETV6 FLT3 RUNX1
17 leukemia, chronic myeloid 30.0 ABL1 ETV6 FLT3 HOTAIR IKZF1 JAK2
18 acute lymphoblastic leukemia, childhood 12.4
19 acute non lymphoblastic leukemia 12.2
20 acute lymphoblastic leukemia congenital sporadic aniridia 12.0
21 lymphoblastic lymphoma 11.9
22 acute t cell leukemia 11.8
23 precursor lymphoblastic lymphoma/leukemia 11.7
24 t-cell childhood acute lymphocytic leukemia 11.6
25 bone marrow necrosis 11.4
26 leukemia, chronic lymphocytic 11.4
27 precursor b lymphoblastic lymphoma/leukemia 11.4
28 t-cell adult acute lymphocytic leukemia 11.2
29 null-cell leukemia 11.2
30 medulloblastoma 11.0
31 precursor t-lymphoblastic lymphoma/leukemia 11.0
32 childhood precursor t-lymphoblastic lymphoma/leukemia 11.0
33 acute myeloid leukemia with t(8;21)(q22;q22) translocation 10.9 FLT3 RUNX1
34 core binding factor acute myeloid leukemia 10.7 FLT3 JAK2 RUNX1
35 platelet disorder, familial, with associated myeloid malignancy 10.7 ETV6 RUNX1
36 atypical chronic myeloid leukemia 10.7 ABL1 JAK2 RUNX1
37 lymphoma 10.7
38 bone marrow cancer 10.6 ABL1 ETV6 FLT3 JAK2 RUNX1
39 neutrophilia, hereditary 10.5 FLT3 JAK2
40 hematologic cancer 10.5 ABL1 ETV6 FLT3 IKZF1 JAK2 NOTCH1
41 mn1 10.4 ETV6 FLT3
42 glucocorticoid resistance, generalized 10.3
43 hematopoietic stem cell transplantation 10.3
44 prostate cancer 10.3
45 aging 10.2
46 sarcoma 10.2
47 down syndrome 10.2
48 osteonecrosis 10.1
49 thrombosis 10.1
50 wilms tumor 5 10.1

Comorbidity relations with Lymphoblastic Leukemia via Phenotypic Disease Network (PDN):


Deficiency Anemia Leukemia, Chronic Lymphocytic
Neutropenia

Graphical network of the top 20 diseases related to Lymphoblastic Leukemia:



Diseases related to Lymphoblastic Leukemia

Symptoms & Phenotypes for Lymphoblastic Leukemia

UMLS symptoms related to Lymphoblastic Leukemia:


angina pectoris, chest pain, edema

MGI Mouse Phenotypes related to Lymphoblastic Leukemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.29 ABL1 AFF4 CRLF2 ETV6 FLT3 IKZF1
2 hematopoietic system MP:0005397 10.27 ABL1 AFF4 CRLF2 ETV6 FLT3 IKZF1
3 growth/size/body region MP:0005378 10.22 RUNX1 TAL2 TCF3 ABL1 AFF4 ETV6
4 endocrine/exocrine gland MP:0005379 10.21 FLT3 IKZF1 JAK2 NBN NOTCH1 PBX1
5 embryo MP:0005380 10.16 NOTCH1 PBX1 RUNX1 TCF3 ABL1 AFF4
6 immune system MP:0005387 10.13 RUNX1 TCF3 ABL1 CRLF2 ETV6 FLT3
7 mortality/aging MP:0010768 10 ABL1 AFF4 CRLF2 ETV6 FLT3 IKZF1
8 liver/biliary system MP:0005370 9.86 ABL1 IKZF1 JAK2 LMO2 NOTCH1 PBX1
9 neoplasm MP:0002006 9.61 ETV6 FLT3 IKZF1 JAK2 LMO2 NBN
10 respiratory system MP:0005388 9.17 NOTCH1 PBX1 RUNX1 ABL1 AFF4 CRLF2

Drugs & Therapeutics for Lymphoblastic Leukemia

FDA approved drugs:

(show all 7)
# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Arranon 18 49 NELARABINE GlaxoSmithKline October 2005
2
Blincyto 18 49 BLINATUMOMAB Amgen December 2014
3
Clolar 18 49 CLOFARABINE Genzyme December, 2004
4
Erwinaze 18 49 asparaginase Erwinia chrysanthemi Eusa Pharma November of 2011
5
Iclusig 18 49 PONATINIB HYDROCHLORIDE Ariad Pharmaceuticals December 2012
6
Marqibo 18 49 VINCRISTINE SULFATE Talon Therapeutics August 2012
7
Sprycel 18 49 DASATINIB Bristol-Myers Squibb June 2006

Drugs for Lymphoblastic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 693)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 302962-49-8 3062316
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
3
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1959-05-2, 59-05-2 126941
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
5
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 147-94-4 6253
6
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 20830-81-3 30323
7
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58957-92-9 42890
8
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2068-78-2, 57-22-7 5978
9
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
10
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 23214-92-8 31703
11
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 130167-69-0
12
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 135968-09-1
13
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
14
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
15
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 174722-31-7 10201696
16
Cladribine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 4291-63-8 20279
17
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 33419-42-0 36462
18
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 21679-14-1, 75607-67-9 30751
19
Teniposide Approved Phase 4,Phase 3,Phase 2,Not Applicable 29767-20-2 34698
20
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 154-42-7 2723601
21
Vindesine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 59917-39-4, 53643-48-4 40839
22
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 58-61-7 60961
23
Pentostatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53910-25-1 40926 439693
24
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 3778-73-2 3690
25
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-23-7 5754
26
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 65271-80-9 4212
27
Chlorambucil Approved Phase 4,Phase 3,Phase 2,Phase 1 305-03-3 2708
28
Vidarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 24356-66-9 32326 21704
29
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
30
Thiotepa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52-24-4 5453
31
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 55-98-1 2478
32
Valganciclovir Approved, Investigational Phase 4,Phase 2,Not Applicable 175865-60-8 64147
33
Dopamine Approved Phase 4,Not Applicable 51-61-6, 62-31-7 681
34
Methylphenidate Approved, Investigational Phase 4,Not Applicable 113-45-1 4158
35
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 3081921 477468
36
Posaconazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 171228-49-2 147912
37
Oprelvekin Approved, Investigational Phase 4 145941-26-0
38
Menthol Approved Phase 4,Not Applicable 2216-51-5 16666
39
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 14956 5280965
40
Nicotine Approved Phase 4 54-11-5 942 89594
41
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-30-3 6037
42
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 143 6006
43
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 1406-16-2
44
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 3,Early Phase 1,Not Applicable 67-97-0 6221 5280795
45
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 50-14-6 5280793
46
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 31703
47
Butyric Acid Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 107-92-6 264
48
Treosulfan Investigational Phase 4,Phase 3,Phase 2,Phase 1 299-75-2 9296
49
Lactitol Investigational Phase 4,Phase 2,Phase 1 585-86-4 3871
50 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 2767)
# Name Status NCT ID Phase Drugs
1 Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients Unknown status NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
2 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
3 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
4 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
5 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
6 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
7 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
8 Efficacy and Safety of Nipent, Cytoxan and Rituxan in the Treatment of Chronic Lymphocytic Leukemia. Unknown status NCT00131313 Phase 4 Nipent, Cytoxan, Rituxan
9 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
10 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
11 Low Grade Lymphoma Unknown status NCT01698866 Phase 4
12 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
13 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
14 LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4 Prednisolone;Daunorubicin;Vincristine;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside
15 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin;Mercaptopurine;Prednisone;Vincristine;Methotrexate
16 LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive Completed NCT00526305 Phase 4 Vincristine;Daunorubicin;Prednisone;L-Asparaginase;Mitoxantrone;Cytosine Arabinoside;Hydrocortisone;Mercaptopurine;Cyclophosphamide;Dexamethasone
17 Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
18 A Study of MabThera Added to Bendamustine or Chlorambucil in Patients With Chronic Lymphocytic Leukemia (MaBLe) Completed NCT01056510 Phase 4 bendamustine;chlorambucil;rituximab [MabThera/Rituxan]
19 ALL-REZ BFM 2002: Multi-Center Study for Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
20 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
21 Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
22 Antiviral Treatment of Chronic Lymphocytic Leukemia Completed NCT01255644 Phase 4 Valganciclovir
23 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
24 A Study to Compare Mabthera (Rituximab), Fludarabine and Cyclophosphamide to Mabthera and Chlorambucil in Patients With Chronic Lymphocytic Leukemia and Unfavourable Somatic Status Completed NCT01283386 Phase 4 chlorambucil;cyclophosphamide;fludarabine;rituximab [MabThera]
25 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4 Methylphenidate
26 LAL-BR/2001: Study Treatment to Low Risk ALL Completed NCT00526175 Phase 4 Prednisone;Vincristine;Daunorubicin;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside;Mercaptopurine;VP-16
27 Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Completed NCT01200355 Phase 4 micafungin;posaconazole
28 A Study to Confirm the Efficacy and Safety of Fludarabine Phosphate Administered in Untreated Chronic Lymphocytic Leukemia Patients With Anemia and/or Thrombocytopenia Completed NCT00220311 Phase 4 Fludarabine Phosphate (Fludara)
29 Efficacy and Safety of Ofatumumab Retreatment and Maintenance Treatment in Patients With B-cell Chronic Lymphocytic Leukemia (CLL) Completed NCT00802737 Phase 4 Ofatumumab
30 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4 rhIL-11
31 The Duration of Humoral Immunity and the Memory Cell Function After Vaccination With 7-valent Pneumococcal Conjugate Vaccine in CLL Completed NCT00919321 Phase 4
32 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
33 Effect of Epoetin Alfa on Hemoglobin, Symptom Distress, and Quality of Life in Patients Receiving Chemotherapy Completed NCT00524407 Phase 4 Epoetin alfa
34 The Study on the Pharmacokinetics of PEG-rhG-CSF in Children and Adolescents Completed NCT02953730 Phase 4 PEG-rhG-CSF
35 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4 Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
36 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
37 Nilotinib in Newly Diagnosed Adult Philadelphia Chromosome & /or BCR-ABL Positive Chronic Myeloid Leukaemia in Chronic Phase Completed NCT01061177 Phase 4 Nilotinib
38 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
39 Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years) Recruiting NCT01366898 Phase 4 Dexamethasona, Idarubicine, ARA-C, Methotrexate
40 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Recruiting NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
41 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Recruiting NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
42 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
43 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid Recruiting NCT01906671 Phase 4 Xaluprine;Puri-Nethol
44 PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years Recruiting NCT01358201 Phase 4 vINCRISTINE;Dexamethasone;Methotrexate;Cytosine arabinoside
45 Vaccinating Children After Chemotherapy Recruiting NCT02447718 Phase 4
46 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
47 Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Recruiting NCT02036489 Phase 4 Vincristine;Daunorubicin;Prednisone;L-asparaginase;Ciclophosphamide;Metotrexate;ARA-C;Hidrocortisone;Mercaptopurine;VP-16;Dexametasone
48 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4 Anti-human Thymoglobulin;Placebo
49 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate
50 A Clinical Trial of Decitabine in Relapse and Refractory T-lymphoblastic Lymphoma Recruiting NCT03558412 Phase 4 Decitabine

Search NIH Clinical Center for Lymphoblastic Leukemia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: leukemia, lymphoid

Genetic Tests for Lymphoblastic Leukemia

Anatomical Context for Lymphoblastic Leukemia

MalaCards organs/tissues related to Lymphoblastic Leukemia:

41
B Cells, T Cells, Bone, Bone Marrow, Myeloid, B Lymphoblasts, Kidney

Publications for Lymphoblastic Leukemia

Articles related to Lymphoblastic Leukemia:

(show top 50) (show all 3893)
# Title Authors Year
1
Mutational status of NRAS, KRAS, and PTPN11 genes is associated with genetic/cytogenetic features in children with B-precursor acute lymphoblastic leukemia. ( 28853218 )
2018
2
Low Incidence of Osteonecrosis in Childhood Acute Lymphoblastic Leukemia Treated With ALL-97 and ALL-02 Study of Japan Association of Childhood Leukemia Study Group. ( 29360413 )
2018
3
Acute Lymphoblastic Leukemia Presenting as Fanconi Syndrome. ( 29515412 )
2018
4
Immunosuppressive monocytes (CD14<sup>+</sup>/HLA-DR<sup>low/-</sup>) increase in childhood precursor B-cell acute lymphoblastic leukemia after induction chemotherapy. ( 29429058 )
2018
5
Genetic predisposition to B-cell acute lymphoblastic leukemia at 14q11.2 is mediated by a CEBPE promoter polymorphism. ( 29977016 )
2018
6
The histone demethylase PHF8 promotes adult acute lymphoblastic leukemia through interaction with the MEK/ERK signaling pathway. ( 29330049 )
2018
7
Anti-E Detected in a 7-Month-Old Infant with Acute Lymphoblastic Leukemia after Transfusion. ( 29945333 )
2018
8
Long non-coding RNA PAX8-AS1 polymorphisms increase the risk of childhood acute lymphoblastic leukemia. ( 29435279 )
2018
9
Exposure-adjusted adverse events comparing blinatumomab with chemotherapy in advanced acute lymphoblastic leukemia. ( 29954814 )
2018
10
<i>PDGFRB</i> mutation and tyrosine kinase inhibitor resistance in Ph-like acute lymphoblastic leukemia. ( 29434033 )
2018
11
Outcome of pediatric patients with acute lymphoblastic leukemia/lymphoblastic lymphoma with hypersensitivity to pegaspargase treated with PEGylated Erwinia asparaginase, pegcrisantaspase: A report from the Children's Oncology Group. ( 29090524 )
2018
12
Lymphomatoid Granulomatosis in a 14-Year-Old Boy with Trisomy 21 and History of B-Lymphoblastic Leukemia/Lymphoma. ( 29336635 )
2018
13
Erratum: Cooperation of IRAK1/4 inhibitor and ABT-737 in nanoparticles for synergistic therapy of T cell acute lymphoblastic leukemia [Corrigendum]. ( 29443320 )
2018
14
Study of NOTCH1 and FBXW7 Mutations and Its Prognostic Significance in South Indian T-Cell Acute Lymphoblastic Leukemia. ( 29200162 )
2018
15
Daratumumab for relapsed/refractory Philadelphia-positive acute lymphoblastic leukemia. ( 29954929 )
2018
16
A rare e14a3 BCR/ABL fusion transcript in acute lymphoblastic leukemia patient treated with CAR-modified T-cell therapy. ( 29434963 )
2018
17
Both left ventricular papillary muscles necrosis, an eosinophylic lymphoblastic leukemia revealed by endomyocardial fibrosis. ( 29366603 )
2018
18
Combination of Blinatumomab and Vincristine Sulfate Liposome Injection for Treatment of Relapsed Philadelphia Chromosome Positive B-cell Acute Lymphoblastic Leukemia. ( 29953129 )
2018
19
Expression of miR-652-3p and Effect on Apoptosis and Drug Sensitivity in Pediatric Acute Lymphoblastic Leukemia. ( 29967774 )
2018
20
Anti-leukemic treatment-induced neurotoxicity in long-term survivors of childhood acute lymphoblastic leukemia: impact of reduced central nervous system radiotherapy and intermediate- to high-dose methotrexate. ( 29424258 )
2018
21
Flow cytometric characterization of acute leukemia reveals a distinctive &amp;quot;blast gate&amp;quot; of murine T-lymphoblastic leukemia/lymphoma. ( 29416774 )
2018
22
Extranodal histiocytic sarcoma in a child with acute lymphoblastic leukemia: Cytomorphological features of a rare entity with brief review of literature. ( 29676378 )
2018
23
Successful Combination Therapy of Liposomal Amphotericin B and Caspofungin for Disseminated Fusariosis in a Pediatric Patient with Acute Lymphoblastic Leukemia. ( 29438132 )
2018
24
Overexpression of Lhx2 suppresses proliferation of human T cell acute lymphoblastic leukemia-derived cells, partly by reducing LMO2 protein levels. ( 29278703 )
2018
25
Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia &amp;amp; lymphoma study. ( 29728694 )
2018
26
Hyper-CVAD plus nelarabine in newly diagnosed adult T-cell acute lymphoblastic leukemia and T-lymphoblastic lymphoma. ( 29047158 )
2018
27
Therapeutic Targeting of mTOR in T-Cell Acute Lymphoblastic Leukemia: An Update. ( 29949919 )
2018
28
Transformation of Chronic Lymphocytic Leukemia (CLL) into B-cell Acute Lymphoblastic Leukemia (ALL). ( 29437555 )
2018
29
A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing. ( 29954933 )
2018
30
Living on a farm, contact with farm animals and pets, and childhood acute lymphoblastic leukemia: pooled and meta-analyses from the Childhood Leukemia International Consortium. ( 29663688 )
2018
31
Possible roles of genetic variations in chemotherapy related cardiotoxicity in pediatric acute lymphoblastic leukemia and osteosarcoma. ( 29970035 )
2018
32
Advanced parental age as risk factor for childhood acute lymphoblastic leukemia: results from studies of the Childhood Leukemia International Consortium. ( 29761423 )
2018
33
Recent Developments in Adolescent and Young Adult (AYA) Acute Lymphoblastic Leukemia. ( 29442287 )
2018
34
Whole-exome sequencing exploration of acquired uniparental disomies in B-cell precursor acute lymphoblastic leukemia. ( 29967378 )
2018
35
Nephrogenic diabetes insipidus in initial stage of acute lymphoblastic leukemia and relapse after haploidentical hematopoietic stem-cell transplantation: A case report. ( 29901649 )
2018
36
A case of B-cell precursor acute lymphoblastic leukemia with IL3-IGH rearrangement revealed by thromboembolism and marked eosinophilia. ( 29424254 )
2018
37
Brain morphology and information processing at the completion of chemotherapy-only treatment for pediatric acute lymphoblastic leukemia. ( 29969366 )
2018
38
Body composition in long-term survivors of acute lymphoblastic leukemia diagnosed in childhood and adolescence: A focus on sarcopenic obesity. ( 29231963 )
2018
39
A decrease in vitamin D levels is associated with methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia. ( 29922939 )
2018
40
Acute lymphoblastic leukemia and lymphoblastic lymphoma in adolescents and young adults. ( 29418064 )
2018
41
Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21. ( 29449437 )
2018
42
Comparing osteonecrosis clinical phenotype, timing, and risk factors in children and young adults treated for acute lymphoblastic leukemia. ( 29943905 )
2018
43
Pediatric-Inspired Treatment Regimens for Adolescents and Young Adults With Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia: A Review. ( 29450465 )
2018
44
Ikaros family zinc-finger 1 mutation is an independent factor for the poor prognosis of adult B-cell acute lymphoblastic leukemia, and allogeneic hematopoietic stem cell transplantation canA improve clinical outcomes. ( 29942002 )
2018
45
Recent Advances in the Biology and Treatment of T Cell Acute Lymphoblastic Leukemia. ( 29948644 )
2018
46
Acute lymphoblastic leukemia in a male with Simpson-Golabi-Behmel syndrome. ( 29737011 )
2018
47
Current paradigms in the management of Philadelphia chromosome positive acute lymphoblastic leukemia in adults. ( 28971501 )
2018
48
In vitro combinatorial anti-proliferative and immunosuppressive effects of Brucea javanica extract with CX-4945 and imatinib in human T-cell acute lymphoblastic leukemia cells. ( 29966986 )
2018
49
T-Lymphoblastic Leukemia/Lymphoma With Annular Skin Rash and Epidermotropism. ( 29443697 )
2018
50
Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice. ( 29441205 )
2018

Variations for Lymphoblastic Leukemia

Expression for Lymphoblastic Leukemia

Search GEO for disease gene expression data for Lymphoblastic Leukemia.

Pathways for Lymphoblastic Leukemia

GO Terms for Lymphoblastic Leukemia

Cellular components related to Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.7 ABL1 AFF4 BCL9 IKZF1 JAK2 LMO2
2 nucleus GO:0005634 9.5 ABL1 AFF4 BCL9 ETV6 FLT3 IKZF1

Biological processes related to Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.96 ABL1 AFF4 ETV6 IKZF1 LYL1 NOTCH1
2 positive regulation of cell proliferation GO:0008284 9.89 CRLF2 FLT3 JAK2 NOTCH1 PBX1
3 regulation of cell proliferation GO:0042127 9.73 ABL1 JAK2 NOTCH1 PBX1
4 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.71 ABL1 FLT3 JAK2
5 cell differentiation GO:0030154 9.7 ABL1 ETV6 FLT3 JAK2 NOTCH1 PBX1
6 B cell differentiation GO:0030183 9.54 FLT3 LYL1 TCF3
7 positive regulation of transcription of Notch receptor target GO:0007221 9.52 NOTCH1 PBX1
8 negative regulation of cell-cell adhesion GO:0022408 9.51 ABL1 JAK2
9 hematopoietic stem cell proliferation GO:0071425 9.48 ETV6 RUNX1
10 signal transduction in response to DNA damage GO:0042770 9.4 ABL1 NBN
11 positive regulation of interferon-gamma secretion GO:1902715 9.32 ABL1 HMHB1
12 regulation of hematopoietic stem cell differentiation GO:1902036 9.26 ABL1 LMO2 RUNX1 TCF3
13 positive regulation of transcription by RNA polymerase II GO:0045944 9.23 BCL9 ETV6 IKZF1 LMO2 NOTCH1 PBX1
14 transcription, DNA-templated GO:0006351 10.11 AFF4 ETV6 IKZF1 LYL1 NOTCH1 PBX1

Molecular functions related to Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding transcription factor activity GO:0003700 9.7 AFF4 ETV6 IKZF1 NOTCH1 PBX1 RUNX1
2 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 9.56 ETV6 IKZF1 LMO2 LYL1 PBX1 RUNX1
3 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001190 9.32 LMO2 NOTCH1
4 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.1 ETV6 LMO2 LYL1 PBX1 RUNX1 TAL2
5 protein binding GO:0005515 10.19 ABL1 AFF4 BCL9 CRLF2 ETV6 FLT3

Sources for Lymphoblastic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM