Lymphoblastic Leukemia, Acute, with Lymphomatous Features disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

LALL MCID: LYM138 MIFTS: 49	Lymphoblastic Leukemia, Acute, with Lymphomatous Features (LALL) Categories: Cancer diseases, Immune diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Lymphoblastic Leukemia, Acute, with Lymphomatous Features

MalaCards integrated aliases for Lymphoblastic Leukemia, Acute, with Lymphomatous Features:

Name: Lymphoblastic Leukemia, Acute, with Lymphomatous Features ⁵⁷ ²⁹ ⁶

Acute Lymphoblastic Leukemia with Lymphomatous Features ⁷³

Leukemia, Acute Lymphoblastic ⁵⁷

Lymphomatous All ⁵⁷

Lall ⁵⁷

Characteristics:

OMIM:

⁵⁷

Inheritance:
acquired specific neoplasm by autosomal recessive mechanism through somatic cell mutation

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁷ 247640

MedGen ⁴² C1855472

SNOMED-CT via HPO ⁶⁹ 115244002 118600007 188676008 more

UMLS ⁷³ C1855472

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Summaries for Lymphoblastic Leukemia, Acute, with Lymphomatous Features

MalaCards based summary : Lymphoblastic Leukemia, Acute, with Lymphomatous Features, also known as acute lymphoblastic leukemia with lymphomatous features, is related to leukemia, acute lymphoblastic and leukemia, acute lymphoblastic 3. An important gene associated with Lymphoblastic Leukemia, Acute, with Lymphomatous Features is ABL1 (ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. Affiliated tissues include myeloid, t cells and bone, and related phenotypes are lymphoma and t-cell acute lymphoblastic leukemias

Description from OMIM: 247640

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Related Diseases for Lymphoblastic Leukemia, Acute, with Lymphomatous Features

Diseases related to Lymphoblastic Leukemia, Acute, with Lymphomatous Features via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)

#	Related Disease	Score	Top Affiliating Genes
1	leukemia, acute lymphoblastic	12.9
2	leukemia, acute lymphoblastic 3	12.4
3	leukemia, acute lymphoblastic 2	12.4
4	acute lymphocytic leukemia	11.6
5	lymphocytic leukemia	10.7
6	leukemia	10.6
7	thrombocythemia 3	10.1	INSL6 JAK2
8	lymphoid leukemia	10.1	INSL6 JAK2
9	stuttering	10.1
10	myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1	10.1	FGFR1 JAK2
11	myelodysplastic myeloproliferative cancer	10.1	ABL1 JAK2
12	jak3-deficient severe combined immunodeficiency	10.1	JAK1 JAK3
13	atypical chronic myeloid leukemia	10.1	ABL1 JAK2
14	chronic eosinophilic leukemia	10.1	ABL1 FGFR1
15	primary polycythemia	10.0	ABL1 JAK1 JAK2
16	lactocele	10.0	JAK1 JAK2 JAK3
17	thrombocytopenia-absent radius syndrome	10.0	FGFR1 JAK2
18	t-cell prolymphocytic leukemia	10.0	ABL1 JAK1 JAK3
19	leukemia, acute myeloid	9.9
20	myeloid leukemia	9.9
21	leukemia, chronic myeloid	9.9	ABL1 FGFR1 JAK2
22	hematologic cancer	9.9	ABL1 FGFR1 JAK2
23	severe combined immunodeficiency, x-linked	9.9	IL7R JAK3
24	systemic mastocytosis	9.9	FGFR1 JAK2
25	combined t cell and b cell immunodeficiency	9.9	IL7R JAK3
26	polycythemia vera	9.9	ABL1 JAK1 JAK2 JAK3
27	myeloproliferative neoplasm	9.8	ABL1 FGFR1 JAK2 JAK3
28	bone marrow cancer	9.8	ABL1 FGFR1 JAK2 JAK3
29	interleukin-7 receptor alpha deficiency	9.8	CRLF2 IL7R JAK3
30	acute leukemia	9.8
31	lymphosarcoma	9.8

Graphical network of the top 20 diseases related to Lymphoblastic Leukemia, Acute, with Lymphomatous Features:

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Symptoms & Phenotypes for Lymphoblastic Leukemia, Acute, with Lymphomatous Features

Symptoms via clinical synopsis from OMIM:

⁵⁷

Heme:
acute lymphoblastic leukemia (all)
lymphomatous all (lall)
t-cell all

Lab:
chromosome loss of bands 9p22-p21 by deletion, unbalanced translocation, or loss of entire chromosome
loss of methylthioadenosine phosphorylase in malignant cells during relapse

Misc:
bulky disease of lymph nodes, spleen, and mediastinum

Clinical features from OMIM:

247640

Human phenotypes related to Lymphoblastic Leukemia, Acute, with Lymphomatous Features:

³²

#	Description	HPO Frequency	HPO Source Accession
1	lymphoma ³²		HP:0002665
2	t-cell acute lymphoblastic leukemias ³²		HP:0006727

GenomeRNAi Phenotypes related to Lymphoblastic Leukemia, Acute, with Lymphomatous Features according to GeneCards Suite gene sharing:

²⁶ (show all 36)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00221-A-1	10	ABL1 FGFR1
2	Decreased viability	GR00221-A-2	10	ABL1 FGFR1 JAK1 JAK2
3	Decreased viability	GR00221-A-3	10	ABL1
4	Decreased viability	GR00342-S-1	10	ABL1
5	Decreased viability	GR00342-S-2	10	ABL1
6	Decreased viability	GR00342-S-3	10	ABL1
7	Decreased viability	GR00402-S-2	10	ABL1 FGFR1 JAK1 JAK2
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-100	9.87	ABL1 FGFR1
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-105	9.87	ABL1 JAK3
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-11	9.87	JAK3
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-123	9.87	ABL1
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-125	9.87	FGFR1
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-126	9.87	FGFR1
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-143	9.87	IL7R
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-149	9.87	JAK3
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-151	9.87	ABL1
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-156	9.87	IL7R
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-157	9.87	ABL1
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-169	9.87	FGFR1
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-183	9.87	FGFR1
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-189	9.87	IL7R
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-195	9.87	JAK3
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-197	9.87	IL7R
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-2	9.87	IL7R
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-3	9.87	ABL1
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-30	9.87	ABL1
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	9.87	ABL1 FGFR1 IL7R JAK3
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-47	9.87	ABL1 FGFR1
29	Increased shRNA abundance (Z-score > 2)	GR00366-A-50	9.87	FGFR1
30	Increased shRNA abundance (Z-score > 2)	GR00366-A-6	9.87	JAK3
31	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	9.87	FGFR1
32	Increased shRNA abundance (Z-score > 2)	GR00366-A-83	9.87	ABL1 FGFR1
33	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	9.87	ABL1 JAK3
34	Increased shRNA abundance (Z-score > 2)	GR00366-A-96	9.87	JAK3
35	Decreased human cytomegalovirus (HCMV) strain AD169 replication	GR00248-A	9.56	ABL1 FGFR1 JAK1 JAK3
36	Decreased viability in HMC1.1 cells	GR00105-A-0	8.96	JAK1 JAK3

MGI Mouse Phenotypes related to Lymphoblastic Leukemia, Acute, with Lymphomatous Features:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	9.8	ABL1 CRLF2 FGFR1 IL7R INSL6 JAK2
2	endocrine/exocrine gland	MP:0005379	9.76	ABL1 CRLF2 FGFR1 IL7R INSL6 JAK1
3	hematopoietic system	MP:0005397	9.56	ABL1 CRLF2 FGFR1 IL7R JAK1 JAK2
4	immune system	MP:0005387	9.17	ABL1 CRLF2 FGFR1 IL7R JAK1 JAK2

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Drugs & Therapeutics for Lymphoblastic Leukemia, Acute, with Lymphomatous Features

Search Clinical Trials , NIH Clinical Center for Lymphoblastic Leukemia, Acute, with Lymphomatous Features

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Genetic Tests for Lymphoblastic Leukemia, Acute, with Lymphomatous Features

Genetic tests related to Lymphoblastic Leukemia, Acute, with Lymphomatous Features:

#	Genetic test	Affiliating Genes
1	Lymphoblastic Leukemia, Acute, with Lymphomatous Features ²⁹

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Anatomical Context for Lymphoblastic Leukemia, Acute, with Lymphomatous Features

MalaCards organs/tissues related to Lymphoblastic Leukemia, Acute, with Lymphomatous Features:

⁴¹

Myeloid, T Cells, Bone, Bone Marrow, Testes, Lymph Node, Spleen

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Publications for Lymphoblastic Leukemia, Acute, with Lymphomatous Features

Articles related to Lymphoblastic Leukemia, Acute, with Lymphomatous Features:

#	Title	Authors	Year
1	Molecular analysis of the CALM/AF10 fusion: identical rearrangements in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma patients. ( 10637482 )		2000
2	Expression of MDR1 gene in acute leukemia cells: association with CD7+ acute myeloblastic leukemia/acute lymphoblastic leukemia. ( 7694687 )		1993

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Genes for Lymphoblastic Leukemia, Acute, with Lymphomatous Features

Genes related to Lymphoblastic Leukemia, Acute, with Lymphomatous Features (4 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	418.47	Pathogenic/Likely pathogenic ⁶ GeneCards inferred via : Variants (show sections)
2	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	418.47	Pathogenic/Likely pathogenic ⁶ GeneCards inferred via : Variants (show sections)
3	CRLF2	Cytokine Receptor Like Factor 2	Protein Coding	408.12	Pathogenic ⁶ GeneCards inferred via : Variants (show sections)
4	LALL	Lymphomatous Acute Lymphoblastic Leukemia	Genetic Locus	50	Genetic linkage ⁵⁷
5	JAK1	Janus Kinase 1	Protein Coding	18.67	GeneCards inferred via : Variants (show sections)
6	JAK2	Janus Kinase 2	Protein Coding	18.67	GeneCards inferred via : Variants (show sections)
7	INSL6	Insulin Like 6	Protein Coding	18.67	GeneCards inferred via : Variants (show sections)
8	JAK3	Janus Kinase 3	Protein Coding	18.47	GeneCards inferred via : Variants (show sections)
9	IL7R	Interleukin 7 Receptor	Protein Coding	18.12	GeneCards inferred via : Variants (show sections)
10	NT5C2	5'-Nucleotidase, Cytosolic II	Protein Coding	18.12	GeneCards inferred via : Variants (show sections)

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Variations for Lymphoblastic Leukemia, Acute, with Lymphomatous Features

ClinVar genetic disease variations for Lymphoblastic Leukemia, Acute, with Lymphomatous Features:

⁶ (show all 33)

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	ABL1	NM_007313.2(ABL1): c.1001C> T (p.Thr334Ile)	single nucleotide variant	Pathogenic/Likely pathogenic	rs121913459	GRCh37	Chromosome 9, 133748283: 133748283
2	ABL1	NM_007313.2(ABL1): c.1001C> T (p.Thr334Ile)	single nucleotide variant	Pathogenic/Likely pathogenic	rs121913459	GRCh38	Chromosome 9, 130872896: 130872896
3	ABL1	NM_007313.2(ABL1): c.814T> C (p.Tyr272His)	single nucleotide variant	Pathogenic/Likely pathogenic	rs121913461	GRCh37	Chromosome 9, 133738357: 133738357
4	ABL1	NM_007313.2(ABL1): c.814T> C (p.Tyr272His)	single nucleotide variant	Pathogenic/Likely pathogenic	rs121913461	GRCh38	Chromosome 9, 130862970: 130862970
5	JAK3	NM_000215.3(JAK3): c.2164G> A (p.Val722Ile)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs3213409	GRCh37	Chromosome 19, 17945696: 17945696
6	JAK3	NM_000215.3(JAK3): c.2164G> A (p.Val722Ile)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs3213409	GRCh38	Chromosome 19, 17834887: 17834887
7	JAK3	NM_000215.3(JAK3): c.394C> A (p.Pro132Thr)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs3212723	GRCh37	Chromosome 19, 17954215: 17954215
8	JAK3	NM_000215.3(JAK3): c.394C> A (p.Pro132Thr)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs3212723	GRCh38	Chromosome 19, 17843406: 17843406
9	FGFR1	NM_023110.2(FGFR1): c.1966A> G (p.Lys656Glu)	single nucleotide variant	Pathogenic/Likely pathogenic	rs869320694	GRCh37	Chromosome 8, 38272308: 38272308
10	FGFR1	NM_023110.2(FGFR1): c.1966A> G (p.Lys656Glu)	single nucleotide variant	Pathogenic/Likely pathogenic	rs869320694	GRCh38	Chromosome 8, 38414790: 38414790
11	JAK1	NM_002227.3(JAK1): c.1901C> A (p.Ala634Asp)	single nucleotide variant	Likely pathogenic	rs869312953	GRCh37	Chromosome 1, 65312418: 65312418
12	JAK1	NM_002227.3(JAK1): c.1901C> A (p.Ala634Asp)	single nucleotide variant	Likely pathogenic	rs869312953	GRCh38	Chromosome 1, 64846735: 64846735
13	INSL6; JAK2	NM_004972.3(JAK2): c.2047A> G (p.Arg683Gly)	single nucleotide variant	Pathogenic/Likely pathogenic	rs1057519721	GRCh37	Chromosome 9, 5078360: 5078360
14	INSL6; JAK2	NM_004972.3(JAK2): c.2047A> G (p.Arg683Gly)	single nucleotide variant	Pathogenic/Likely pathogenic	rs1057519721	GRCh38	Chromosome 9, 5078360: 5078360
15	INSL6; JAK2	NM_004972.3(JAK2): c.2048G> C (p.Arg683Thr)	single nucleotide variant	Pathogenic	rs1057519722	GRCh37	Chromosome 9, 5078361: 5078361
16	INSL6; JAK2	NM_004972.3(JAK2): c.2048G> C (p.Arg683Thr)	single nucleotide variant	Pathogenic	rs1057519722	GRCh38	Chromosome 9, 5078361: 5078361
17	INSL6; JAK2	NM_004972.3(JAK2): c.2049A> C (p.Arg683Ser)	single nucleotide variant	Pathogenic	rs1057519723	GRCh37	Chromosome 9, 5078362: 5078362
18	INSL6; JAK2	NM_004972.3(JAK2): c.2049A> C (p.Arg683Ser)	single nucleotide variant	Pathogenic	rs1057519723	GRCh38	Chromosome 9, 5078362: 5078362
19	INSL6; JAK2	NM_004972.3(JAK2): c.2049A> T (p.Arg683Ser)	single nucleotide variant	Pathogenic	rs1057519723	GRCh37	Chromosome 9, 5078362: 5078362
20	INSL6; JAK2	NM_004972.3(JAK2): c.2049A> T (p.Arg683Ser)	single nucleotide variant	Pathogenic	rs1057519723	GRCh38	Chromosome 9, 5078362: 5078362
21	CRLF2	NM_022148.3(CRLF2): c.695T> G (p.Phe232Cys)	single nucleotide variant	Pathogenic	rs1057519743	GRCh37	Chromosome X, 1314966: 1314966
22	CRLF2	NM_022148.3(CRLF2): c.695T> G (p.Phe232Cys)	single nucleotide variant	Pathogenic	rs1057519743	GRCh38	Chromosome X, 1196852: 1196852
23	CRLF2	NM_022148.3(CRLF2): c.695T> G (p.Phe232Cys)	single nucleotide variant	Pathogenic	rs1057519743	GRCh38	Chromosome Y, 1196852: 1196852
24	JAK1	NM_002227.3(JAK1): c.1972G> T (p.Val658Phe)	single nucleotide variant	Likely pathogenic	rs1057519753	GRCh37	Chromosome 1, 65312347: 65312347
25	JAK1	NM_002227.3(JAK1): c.1972G> T (p.Val658Phe)	single nucleotide variant	Likely pathogenic	rs1057519753	GRCh38	Chromosome 1, 64846664: 64846664
26	IL7R	NM_002185.4(IL7R): c.553A> T (p.Ser185Cys)	single nucleotide variant	Likely pathogenic	rs1057519759	GRCh37	Chromosome 5, 35873597: 35873597
27	IL7R	NM_002185.4(IL7R): c.553A> T (p.Ser185Cys)	single nucleotide variant	Likely pathogenic	rs1057519759	GRCh38	Chromosome 5, 35873495: 35873495
28	JAK1	NM_002227.3(JAK1): c.1937C> T (p.Ser646Phe)	single nucleotide variant	Likely pathogenic	rs151047872	GRCh37	Chromosome 1, 65312382: 65312382
29	JAK1	NM_002227.3(JAK1): c.1937C> T (p.Ser646Phe)	single nucleotide variant	Likely pathogenic	rs151047872	GRCh38	Chromosome 1, 64846699: 64846699
30	NT5C2	NM_012229.4(NT5C2): c.1075A> C (p.Lys359Gln)	single nucleotide variant	not provided	rs1057519867	GRCh37	Chromosome 10, 104852980: 104852980
31	NT5C2	NM_012229.4(NT5C2): c.1075A> C (p.Lys359Gln)	single nucleotide variant	not provided	rs1057519867	GRCh38	Chromosome 10, 103093223: 103093223
32	FGFR1	NM_023110.2(FGFR1): c.1968G> C (p.Lys656Asn)	single nucleotide variant	Likely pathogenic	rs1057519897	GRCh37	Chromosome 8, 38272306: 38272306
33	FGFR1	NM_023110.2(FGFR1): c.1968G> C (p.Lys656Asn)	single nucleotide variant	Likely pathogenic	rs1057519897	GRCh38	Chromosome 8, 38414788: 38414788

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Expression for Lymphoblastic Leukemia, Acute, with Lymphomatous Features

Search GEO for disease gene expression data for Lymphoblastic Leukemia, Acute, with Lymphomatous Features.

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Pathways for Lymphoblastic Leukemia, Acute, with Lymphomatous Features

Pathways related to Lymphoblastic Leukemia, Acute, with Lymphomatous Features according to GeneCards Suite gene sharing:

(show all 41)

#	Super pathways	Score	Top Affiliating Genes
1	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.21	FGFR1 IL7R JAK1 JAK2 JAK3
2	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.15	FGFR1 IL7R JAK1 JAK2 JAK3
3	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.76	FGFR1 IL7R JAK1 JAK2 JAK3
4	NFAT and Cardiac Hypertrophy ⁶⁴ Show member pathways IGF1R Signaling ⁶⁴ Signaling Involved in Cardiac Hypertrophy ⁶⁴	12.68	FGFR1 JAK1 JAK2 JAK3
5	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁵ Show member pathways Adipokines and Insulin Signaling Pathways ⁶⁵ Development Thrombopoietin-regulated cell processes ²² IL-15 Signaling Pathways ⁶⁵ IL-2 Signaling Pathways ⁶⁵ IL-21 Signaling Pathways ⁶⁵ IL-4 Signaling Pathways ⁶⁵ IL-7 Signaling Pathways ⁶⁵ IL-9 Pathway ⁶⁴ IL-9 Signaling Pathways ⁶⁵ Immune response IL-9 signaling pathway ²²	12.58	IL7R JAK1 JAK2 JAK3
6	Glioma ³⁷ Show member pathways EGFR tyrosine kinase inhibitor resistance ³⁷ Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.56	FGFR1 JAK1 JAK2 JAK3
7	Pathways in cancer ³⁷	12.52	ABL1 FGFR1 IL7R JAK1 JAK2 JAK3
8	Development VEGF signaling via VEGFR2 - generic cascades ²² Show member pathways Development VEGF signaling and activation ²² VEGF - VEGF R2 Signaling Pathways ⁶⁵	12.23	JAK1 JAK2 JAK3
9	Development IGF-1 receptor signaling ²² Show member pathways IL-4 Signaling Pathway ¹ Immune response IL-4 signaling pathway ²² Signal transduction AKT signaling ²²	12.22	JAK1 JAK2 JAK3
10	CNTF Signaling ⁶⁴ Show member pathways FLT3 Signaling ⁶⁴ IL-3 Pathway ⁶⁴ Nur77-Induced AICD in Macrophage ⁶⁴ OSM Pathway ⁶⁴	12.16	JAK1 JAK2 JAK3
11	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.09	FGFR1 JAK1 JAK2 JAK3
12	G-protein signaling Ras family GTPases in kinase cascades (scheme) ²² Show member pathways Activation of the AP-1 family of transcription factors ⁶⁶ Immune response Oncostatin M signaling via MAPK in human cells ²² MAPK Cascade ¹ Oncostatin M Signaling Pathway ¹	12.08	JAK1 JAK2 JAK3
13	MAPK Signaling: Mitogen Stimulation Pathway ⁶⁵ Show member pathways Akt Signaling Pathway ⁶⁵	12.04	FGFR1 IL7R JAK1
14	Necroptosis ³⁷ Show member pathways Nanoparticle triggered regulated necrosis ¹	12.04	JAK1 JAK2 JAK3
15	EGF/EGFR Signaling Pathway ¹	12.01	ABL1 JAK1 JAK2
16	G beta-gamma signalling through PI3Kgamma ⁶⁶ Show member pathways G-protein beta-gamma signalling ⁶⁶ GPVI-mediated activation cascade ⁶⁶	11.97	JAK1 JAK2 JAK3
17	AKT Signaling Pathway ⁶⁷	11.96	FGFR1 IL7R JAK1
18	Tyrosine Kinases / Adaptors ⁴	11.95	ABL1 FGFR1 JAK2
19	IL-2 Signaling Pathway ¹ Show member pathways IL2-mediated signaling events ¹ IL-5 Signaling Pathway ¹	11.89	JAK1 JAK2 JAK3
20	Th1 Differentiation Pathway ⁶⁵ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁵	11.87	JAK1 JAK2 JAK3
21	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	11.86	FGFR1 IL7R JAK1 JAK2
22	Signaling pathways regulating pluripotency of stem cells ³⁷	11.85	FGFR1 JAK1 JAK2 JAK3
23	Interleukin-4 and 13 signaling ⁶⁶	11.79	JAK1 JAK2 JAK3
24	Immune response IL-2 activation and signaling pathway ²² Show member pathways Immune response IL-3 activation and signaling pathway ²²	11.77	JAK1 JAK2 JAK3
25	Cytokine production by Th17 cells in CF (Mouse model) ²² Show member pathways Cytokine production by Th17 cells in CF ²²	11.68	JAK1 JAK2 JAK3
26	JAK-STAT signaling pathway (KEGG) ³⁷ Show member pathways Interleukin-19, 20, 22, 24 ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵	11.47	ABL1 CRLF2 IL7R JAK1 JAK2 JAK3
27	IL4-mediated signaling events ¹	11.45	JAK1 JAK2 JAK3
28	Interleukin-11 Signaling Pathway ¹	11.33	JAK1 JAK2
29	RAF-independent MAPK1/3 activation ⁶⁶ Show member pathways MAPK1 (ERK2) activation ⁶⁶ MAPK3 (ERK1) activation ⁶⁶	11.31	JAK1 JAK2
30	Signaling events mediated by TCPTP ¹ Show member pathways MET activates PI3K/AKT signaling ⁶⁶	11.3	JAK1 JAK3
31	IL-7 Signaling Pathway ¹ Show member pathways B-Cell Development ⁶⁴ IL-9 Signaling Pathway ¹	11.3	IL7R JAK1 JAK3
32	Jak-Stat Signaling Pathway (sino) ⁶⁷	11.3	ABL1 IL7R JAK1 JAK2 JAK3
33	Type III Interferon Signaling Pathways ⁶⁵ Show member pathways Type III interferon signaling ¹	11.26	JAK1 JAK2
34	Primary immunodeficiency ³⁷	11.23	IL7R JAK3
35	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway ¹	11.23	CRLF2 IL7R JAK1 JAK2
36	Type II interferon signaling (IFNG) ¹	11.22	JAK1 JAK2
37	Jak/STAT Signaling Pathway Intracellular Regulation ⁶⁵	11.21	JAK1 JAK2 JAK3
38	G-protein signaling_Cross-talk between Ras-family GTPases ²²	11.19	FGFR1 JAK1 JAK2 JAK3
39	Th2 Differentiation Pathway ⁶⁵	11.12	CRLF2 JAK1 JAK2 JAK3
40	Interleukin-7 signaling ⁶⁶	10.99	IL7R JAK1 JAK3
41	Immune response_Oncostatin M signaling via JAK-Stat in human cells ²²	10.9	JAK1 JAK2

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GO Terms for Lymphoblastic Leukemia, Acute, with Lymphomatous Features

Cellular components related to Lymphoblastic Leukemia, Acute, with Lymphomatous Features according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endomembrane system	GO:0012505	8.8	JAK1 JAK2 JAK3

Biological processes related to Lymphoblastic Leukemia, Acute, with Lymphomatous Features according to GeneCards Suite gene sharing:

(show all 27)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation	GO:0008284	9.91	CRLF2 FGFR1 IL7R JAK2
2	protein phosphorylation	GO:0006468	9.8	ABL1 FGFR1 JAK1 JAK2 JAK3
3	protein autophosphorylation	GO:0046777	9.77	ABL1 FGFR1 JAK2
4	phosphorylation	GO:0016310	9.73	ABL1 FGFR1 JAK1 JAK2 JAK3 NT5C2
5	MAPK cascade	GO:0000165	9.67	FGFR1 JAK1 JAK2 JAK3
6	erythrocyte differentiation	GO:0030218	9.63	JAK2 JAK3
7	interleukin-12-mediated signaling pathway	GO:0035722	9.63	JAK1 JAK2
8	B cell proliferation	GO:0042100	9.62	ABL1 IL7R
9	platelet-derived growth factor receptor signaling pathway	GO:0048008	9.62	ABL1 JAK2
10	response to antibiotic	GO:0046677	9.61	JAK1 JAK2
11	interleukin-6-mediated signaling pathway	GO:0070102	9.59	JAK1 JAK2
12	negative regulation of cell-cell adhesion	GO:0022408	9.58	ABL1 JAK2
13	interleukin-15-mediated signaling pathway	GO:0035723	9.58	JAK1 JAK3
14	JAK-STAT cascade involved in growth hormone signaling pathway	GO:0060397	9.57	JAK2 JAK3
15	regulation of interferon-gamma-mediated signaling pathway	GO:0060334	9.56	JAK1 JAK2
16	interleukin-27-mediated signaling pathway	GO:0070106	9.55	JAK1 JAK2
17	cytokine-mediated signaling pathway	GO:0019221	9.55	CRLF2 IL7R JAK1 JAK2 JAK3
18	interleukin-2-mediated signaling pathway	GO:0038110	9.54	JAK1 JAK3
19	interleukin-35-mediated signaling pathway	GO:0070757	9.52	JAK1 JAK2
20	regulation of JAK-STAT cascade	GO:0046425	9.51	JAK2 JAK3
21	interleukin-9-mediated signaling pathway	GO:0038113	9.49	JAK1 JAK3
22	tyrosine phosphorylation of STAT protein	GO:0007260	9.48	JAK2 JAK3
23	enzyme linked receptor protein signaling pathway	GO:0007167	9.46	JAK2 JAK3
24	interleukin-21-mediated signaling pathway	GO:0038114	9.43	JAK1 JAK3
25	peptidyl-tyrosine phosphorylation	GO:0018108	9.35	ABL1 FGFR1 JAK1 JAK2 JAK3
26	positive regulation of STAT cascade	GO:1904894	9.32	CRLF2 IL7R
27	interleukin-7-mediated signaling pathway	GO:0038111	8.92	CRLF2 IL7R JAK1 JAK3

Molecular functions related to Lymphoblastic Leukemia, Acute, with Lymphomatous Features according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ATP binding	GO:0005524	9.88	ABL1 FGFR1 JAK1 JAK2 JAK3
2	kinase activity	GO:0016301	9.77	ABL1 FGFR1 JAK1 JAK2 JAK3
3	protein kinase activity	GO:0004672	9.72	ABL1 FGFR1 JAK1 JAK2 JAK3
4	nucleotide binding	GO:0000166	9.65	FGFR1 JAK1 JAK2 JAK3 NT5C2
5	cytokine receptor activity	GO:0004896	9.46	CRLF2 IL7R
6	Ras guanyl-nucleotide exchange factor activity	GO:0005088	9.46	FGFR1 JAK1 JAK2 JAK3
7	SH2 domain binding	GO:0042169	9.43	ABL1 JAK2
8	growth hormone receptor binding	GO:0005131	9.4	JAK1 JAK2
9	protein tyrosine kinase activity	GO:0004713	9.35	ABL1 FGFR1 JAK1 JAK2 JAK3
10	non-membrane spanning protein tyrosine kinase activity	GO:0004715	8.92	ABL1 JAK1 JAK2 JAK3

Sources

Sources for Lymphoblastic Leukemia, Acute, with Lymphomatous Features

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⁷¹ TGDB

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⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Lymphoblastic Leukemia, Acute, with Lymphomatous Features (LALL)

Aliases & Classifications for Lymphoblastic Leukemia, Acute, with Lymphomatous Features

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Human phenotypes related to Lymphoblastic Leukemia, Acute, with Lymphomatous Features:

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Genes related to Lymphoblastic Leukemia, Acute, with Lymphomatous Features (4 elite genes):

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