MCID: LYM040
MIFTS: 57

Lymphoblastic Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Lymphoblastic Lymphoma

MalaCards integrated aliases for Lymphoblastic Lymphoma:

Name: Lymphoblastic Lymphoma 39 12 77 54 15
Precursor Cell Lymphoblastic Leukemia Lymphoma 74
Precursor Cell Lymphoblastic Lymphoma 74
Lymphoma, Lymphoblastic 54
Lymphoma Lymphoblastic 56

Classifications:



External Ids:

Disease Ontology 12 DOID:0080147
ICD10 34 C83.5

Summaries for Lymphoblastic Lymphoma

Disease Ontology : 12 A lymphoma that has material basis in immature malignant lymphocytes (lymphoblasts) committed to the B-cell or T-cell lineage and located in primarily lymph nodes or located in extranodal sites.

MalaCards based summary : Lymphoblastic Lymphoma, also known as precursor cell lymphoblastic leukemia lymphoma, is related to acute t cell leukemia and leukemia, acute lymphoblastic. An important gene associated with Lymphoblastic Lymphoma is ZMYM2 (Zinc Finger MYM-Type Containing 2), and among its related pathways/superpathways are NF-kappaB Signaling and Transcriptional misregulation in cancer. The drugs Arranon and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Wikipedia : 77 Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the... more...

Related Diseases for Lymphoblastic Lymphoma

Diseases related to Lymphoblastic Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 acute t cell leukemia 31.9 CD7 NOTCH1 TAL1 TRB
2 leukemia, acute lymphoblastic 31.1 DNTT KMT2A MME
3 acute lymphocytic leukemia 30.4 CDKN2B MME NOTCH1 TAL1
4 leukemia, acute lymphoblastic 3 30.1 CDKN2B DNTT KMT2A MME MPO
5 lymphocytic leukemia 29.9 CD5 DNTT KMT2A MME NOTCH1 TAL1
6 ewing's family of tumors 29.8 CDKN2B FLI1
7 myeloid sarcoma 29.8 DNTT KMT2A MPO PTPRC
8 8p11 myeloproliferative syndrome 29.8 FGFR1 ZMYM2
9 bone marrow cancer 29.7 FGFR1 KMT2A MPO ZMYM2
10 acute biphenotypic leukemia 29.7 DNTT KMT2A MPO
11 dendritic cell tumor 29.7 DNTT MPO PTPRC
12 thymoma 29.5 CD5 DNTT PTPRC TRB
13 leukemia, chronic myeloid 29.5 CDKN2B DNTT FGFR1 KMT2A MPO
14 acute leukemia 29.5 CD7 DNTT KMT2A MPO TAL1
15 peripheral t-cell lymphoma 29.4 BCL6 CD5 MME
16 diffuse large b-cell lymphoma 29.4 BCL6 CD5 MME
17 lymphosarcoma 29.3 BCL6 CD5 PTPRC
18 lymphoma, hodgkin, classic 29.2 BCL6 CD5 MME PTPRC
19 mantle cell lymphoma 28.9 BCL6 CD5 MME PTPRC
20 leukemia, acute myeloid 28.5 CD7 CDKN2B DNTT KMT2A MME MPO
21 precursor t-cell acute lymphoblastic leukemia 28.5 CD7 CDKN2B DNTT KMT2A MPO NOTCH1
22 lymphoma, non-hodgkin, familial 28.1 BCL6 CD5 CD7 CDKN2B DNTT MME
23 t-cell childhood lymphoblastic lymphoma 12.5
24 precursor t-lymphoblastic lymphoma/leukemia 12.4
25 precursor b lymphoblastic lymphoma/leukemia 12.3
26 precursor lymphoblastic lymphoma/leukemia 12.3
27 childhood precursor t-lymphoblastic lymphoma/leukemia 12.2
28 precursor t-lymphoblastic lymphoma/leukemia refractory 12.2
29 chromosome 8p11 myeloproliferative syndrome 11.3
30 lymphoma 11.1
31 leukemia 10.7
32 myasthenic syndrome, congenital, 6, presynaptic 10.3 FGFR1 ZMYM2
33 photokeratitis 10.3 DNTT PTPRC
34 chromosomal triplication 10.3 BCL6 KMT2A
35 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.3 BCL6 PTPRC
36 immunodeficiency 18 10.3 PTPRC TAL1
37 ovarian lymphoma 10.2 MME PTPRC
38 t-cell/histiocyte rich large b cell lymphoma 10.2 BCL6 MME
39 chronic monocytic leukemia 10.2 MPO PTPRC
40 extraskeletal ewing sarcoma 10.2 FLI1 PTPRC
41 erythroleukemia, familial 10.2 FLI1 TAL1
42 sarcoma 10.2
43 central nervous system hematologic cancer 10.2 BCL6 MME
44 plasmablastic lymphoma 10.1 BCL6 NOTCH1 PTPRC
45 burkitt lymphoma 10.1
46 thymoma, familial 10.1
47 hematopoietic stem cell transplantation 10.1
48 myeloproliferative neoplasm 10.1
49 hypereosinophilic syndrome 10.1
50 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.1 DNTT KMT2A MPO

Graphical network of the top 20 diseases related to Lymphoblastic Lymphoma:



Diseases related to Lymphoblastic Lymphoma

Symptoms & Phenotypes for Lymphoblastic Lymphoma

GenomeRNAi Phenotypes related to Lymphoblastic Lymphoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 BCL6 CD5 CD7 KMT2A NOTCH1 PTPRC

MGI Mouse Phenotypes related to Lymphoblastic Lymphoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.21 BCL6 CD5 CD7 CDKN2B DNTT FGFR1
2 immune system MP:0005387 10.18 BCL6 CD5 CD7 CDKN2B DNTT FGFR1
3 homeostasis/metabolism MP:0005376 10.1 BCL6 CDKN2B DNTT FGFR1 KMT2A MME
4 cardiovascular system MP:0005385 10 BCL6 FGFR1 FLI1 KMT2A MPO NOTCH1
5 integument MP:0010771 9.87 CD5 CDKN2B FGFR1 KMT2A MME NOTCH1
6 liver/biliary system MP:0005370 9.73 BCL6 FLI1 KMT2A MME NOTCH1 PTPRC
7 no phenotypic analysis MP:0003012 9.63 BCL6 CD5 CDKN2B FGFR1 KMT2A PTPRC
8 normal MP:0002873 9.5 BCL6 CD5 DNTT FGFR1 KMT2A NOTCH1
9 renal/urinary system MP:0005367 9.1 CDKN2B FGFR1 KMT2A NOTCH1 PTPRC TAL1

Drugs & Therapeutics for Lymphoblastic Lymphoma

FDA approved drugs:

# Drug Name Active Ingredient(s) 19 Company Approval Date
1
Arranon 19 50 NELARABINE GlaxoSmithKline October 2005

Drugs for Lymphoblastic Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 692)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1959-05-2, 59-05-2 126941
2
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
3
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 302962-49-8 3062316
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1177-87-3
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
6
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 143 6006
7
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58957-92-9 42890
8
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 20830-81-3 30323
9
Cytarabine Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 147-94-4, 65-46-3 6253
10
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2068-78-2, 57-22-7 5978
11
Mercaptopurine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-44-2 667490
12
Sargramostim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 123774-72-1, 83869-56-1
13
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 174722-31-7 10201696
14
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
15
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 135968-09-1
16
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
17
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
18
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
19
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
20
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 130167-69-0
21
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 23214-92-8 31703
22
Cladribine Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 4291-63-8 20279
23
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 33419-42-0 36462
24
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 154-42-7 2723601
25
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 75607-67-9, 21679-14-1 30751
26
Vindesine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 53643-48-4, 59917-39-4 40839
27
Teniposide Approved Phase 4,Phase 3,Phase 2,Not Applicable 29767-20-2 34698
28
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 3778-73-2 3690
29
Thiotepa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52-24-4 5453
30
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 65271-80-9 4212
31
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-23-7 5754
32
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-03-3
33
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
34
Epirubicin Approved Phase 4,Phase 3,Phase 2 56420-45-2 41867
35
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 55-98-1 2478
36
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 477468 3081921
37
Posaconazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 171228-49-2 147912
38
Dopamine Approved Phase 4,Not Applicable 62-31-7, 51-61-6 681
39
Methylphenidate Approved, Investigational Phase 4,Not Applicable 113-45-1 4158
40
Oprelvekin Approved, Investigational Phase 4,Phase 2 145941-26-0
41
Morphine Approved, Investigational Phase 4,Phase 3,Not Applicable 57-27-2 5288826
42
Decitabine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 2353-33-5 451668
43
Azacitidine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 320-67-2 9444
44
inotuzumab ozogamicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 635715-01-4
45
Nicotine Approved Phase 4,Not Applicable 54-11-5 89594 942
46
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
47
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1401-55-4
48
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 5280965 14956
49
Tyrosine Approved, Investigational, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 60-18-4 6057
50
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-30-3 6037

Interventional clinical trials:

(show top 50) (show all 2062)
# Name Status NCT ID Phase Drugs
1 Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients Unknown status NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
2 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
3 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Unknown status NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
4 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
5 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
6 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
7 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Unknown status NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
8 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
9 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
10 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
11 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
12 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4 Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
13 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
14 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
15 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
16 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
17 LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4 Prednisolone;Daunorubicin;Vincristine;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside
18 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin;Mercaptopurine;Prednisone;Vincristine;Methotrexate
19 Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
20 LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive Completed NCT00526305 Phase 4 Vincristine;Daunorubicin;Prednisone;L-Asparaginase;Mitoxantrone;Cytosine Arabinoside;Hydrocortisone;Mercaptopurine;Cyclophosphamide;Dexamethasone
21 ALL-REZ BFM 2002: Multi-Center Study for Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
22 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
23 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
24 Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
25 Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Completed NCT01200355 Phase 4 micafungin;posaconazole
26 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4 Methylphenidate
27 LAL-BR/2001: Study Treatment to Low Risk ALL Completed NCT00526175 Phase 4 Prednisone;Vincristine;Daunorubicin;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside;Mercaptopurine;VP-16
28 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4 rhIL-11
29 The Study on the Pharmacokinetics of PEG-rhG-CSF in Children and Adolescents Completed NCT02953730 Phase 4 PEG-rhG-CSF
30 Nilotinib in Newly Diagnosed Adult Philadelphia Chromosome & /or BCR-ABL Positive Chronic Myeloid Leukaemia in Chronic Phase Completed NCT01061177 Phase 4 Nilotinib
31 A Clinical Trial of Decitabine in Relapsed or Refractory T-lymphoblastic Lymphoma Recruiting NCT03558412 Phase 4 Decitabine
32 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4 Anti-human Thymoglobulin;Placebo
33 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
34 Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years) Recruiting NCT01366898 Phase 4 Dexamethasona, Idarubicine, ARA-C, Methotrexate
35 A Study Of Two Inotuzumab Ozogamicin Doses in Relapsed/ Refractory Acute Lymphoblastic Leukemia Transplant Eligible Patients Recruiting NCT03677596 Phase 4 inotuzumab ozogamicin-dose level 2;Inotuzumab ozogamicin-dose level 1
36 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
37 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid Recruiting NCT01906671 Phase 4 Xaluprine;Puri-Nethol
38 PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years Recruiting NCT01358201 Phase 4 vINCRISTINE;Dexamethasone;Methotrexate;Cytosine arabinoside
39 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
40 Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Recruiting NCT02036489 Phase 4 Vincristine;Daunorubicin;Prednisone;L-asparaginase;Ciclophosphamide;Metotrexate;ARA-C;Hidrocortisone;Mercaptopurine;VP-16;Dexametasone
41 G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor Recruiting NCT02933333 Phase 4
42 Treatment of High Risk Adult Acute Lymphoblastic Leukemia Active, not recruiting NCT00853008 Phase 4 Vincristine;Daunorubicin;Prednisone;Mitoxantrone;Cytosine Arabinoside;Dexamethasone;Methotrexate (MTX);Cytarabine;ASP;Mercaptopurine;Teniposide;Hydrocortisone
43 Vaccinating Children After Chemotherapy Active, not recruiting NCT02447718 Phase 4
44 Determinants of Mercaptopurine Toxicity in Paediatric Acute Lymphoblastic Leukemia Maintenance Therapy Enrolling by invitation NCT03920813 Phase 4 Mercaptopurine
45 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT Enrolling by invitation NCT03176849 Phase 4
46 ProphyALL - Study on the Safety of Liposomal Amphotericin B to Prevent Antifungal Infections in Elderly Patients With Acute Lymphoblastic Leukemia Terminated NCT00386997 Phase 4 liposomal amphotericin B (AmBisome®)
47 Atomoxetine for Children With Acquired Attentional Disorders Following Completion of Chemotherapy for ALL Terminated NCT00299234 Phase 4 Atomoxetine
48 Combination Chemotx in Treating Children or Adolescents With Newly Diagnosed Stg III or Stg IV Lymphoblastic Lymphoma Unknown status NCT00004228 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate
49 Combination Chemotherapy in Treating Children With Non-Hodgkin's Lymphoma Unknown status NCT00003650 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisone;vincristine sulfate
50 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3 ketamine hydrochloride

Search NIH Clinical Center for Lymphoblastic Lymphoma

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Lymphoblastic Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Lymphoblastic Lymphoma

Anatomical Context for Lymphoblastic Lymphoma

MalaCards organs/tissues related to Lymphoblastic Lymphoma:

42
T Cells, B Cells, Bone, Bone Marrow, Myeloid, B Lymphoblasts, Kidney

The Foundational Model of Anatomy Ontology organs/tissues related to Lymphoblastic Lymphoma:

20
Primarily Lymph Nodes Or

Publications for Lymphoblastic Lymphoma

Articles related to Lymphoblastic Lymphoma:

(show top 50) (show all 692)
# Title Authors Year
1
Non-leukemic pediatric mixed phenotype acute leukemia/lymphoma: Genomic characterization and clinical outcome in a prospective trial for pediatric lymphoblastic lymphoma. ( 30578714 )
2019
2
FDG PET/CT Demonstrated Precursor B-cell Lymphoblastic Lymphoma in a Pediatric Patient With Hemophilia B. ( 31021910 )
2019
3
Steroid-induced Bradycardia During Induction Chemotherapy in Children and Young Adults Diagnosed With Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma. ( 30994505 )
2019
4
A Case of Renal Involvement in B Lymphoblastic Lymphoma Leukemia. ( 30775881 )
2019
5
Expression and significance of CD47, PD1 and PDL1 in T-cell acute lymphoblastic lymphoma/leukemia. ( 30466764 )
2019
6
A Young Man with a Mass: Non-Early Precursor T-Cell Lymphoblastic Lymphoma. ( 30138599 )
2019
7
B-lymphoblastic lymphoma with TCF3-PBX1 fusion gene. ( 30262566 )
2019
8
T-lymphoblastic lymphoma after previous thymoma: how NGS helps establishing the diagnosis and procures new insights. ( 30301393 )
2019
9
Orbital precursor B-lymphoblastic lymphoma involving the extraocular muscles in a 56-year-old male and a review of the literature. ( 30675202 )
2019
10
Cutaneous involvement as the first manifestation of T-lymphoblastic lymphoma and review of the literature. ( 30680766 )
2019
11
Acral Involvement of Lymphoblastic Lymphoma Revealed on FDG PET/CT. ( 30688741 )
2019
12
Sustained Response to Imatinib in a Pediatric Patient with Concurrent Myeloproliferative Disease and Lymphoblastic Lymphoma Associated with a CCDC88C-PDGFRB Fusion Gene. ( 30726835 )
2019
13
Downregulation of specific FBXW7 isoforms with differential effects in T-cell lymphoblastic lymphoma. ( 30742097 )
2019
14
S194-P-FADD as a marker of aggressiveness and poor prognosis in human T-cell lymphoblastic lymphoma. ( 30805584 )
2019
15
Lymphoblastic lymphoma in children and adolescents: review of current challenges and future opportunities. ( 30809797 )
2019
16
Clinical Predictors and Prognostic Model for Pediatric Lymphoblastic Lymphoma Treated With Uniform BFM90 Protocol: A Single-Center Experience of 65 Patients From Asia. ( 30905539 )
2019
17
Detection of novel fusion-transcripts by RNA-Seq in T-cell lymphoblastic lymphoma. ( 30914738 )
2019
18
Primary Cutaneous T-Cell Lymphoblastic Lymphoma: Case Report and Literature Review. ( 30915242 )
2019
19
Circ-LAMP1 promotes T-cell lymphoblastic lymphoma progression via acting as a ceRNA for miR-615-5p to regulate DDR2 expression. ( 30922709 )
2019
20
Complete Blood Count Score Model Integrating Reduced Lymphocyte-Monocyte Ratio, Elevated Neutrophil-Lymphocyte Ratio, and Elevated Platelet-Lymphocyte Ratio Predicts Inferior Clinical Outcomes in Adult T-Lymphoblastic Lymphoma. ( 30952822 )
2019
21
Prognostic and predictive value of a microRNA signature in adults with T-cell lymphoblastic lymphoma. ( 30953029 )
2019
22
Double-hit pancreatic B-lymphoblastic lymphoma with a variant translocation t(2;18)(p11;q21). ( 30963474 )
2019
23
Endovascular mechanical thrombectomy for superior sagittal sinus thrombosis in a patient with T-lymphoblastic lymphoma treated with L-asparaginase. ( 31092500 )
2019
24
Diagnostic challenges in T-lymphoblastic lymphoma, early T-cell precursor acute lymphoblastic leukemia or mixed phenotype acute leukemia: A case report. ( 30313079 )
2018
25
Coexistence of T-cell lymphoblastic lymphoma and acute myeloid leukemia mimicking acute lymphocytic leukemia. ( 30004087 )
2018
26
T-Cell Acute Lymphoblastic Lymphoma Presenting as Dissecting Cellulitis and Cavernous Sinus Syndrome. ( 30418330 )
2018
27
Outcome of adult T-lymphoblastic lymphoma depends on ALL-type chemotherapy, prognostic factors, and performance of allogeneic hematopoietic stem cell transplantation. ( 29995776 )
2018
28
Allogeneic hematopoietic stem cell transplantation should be in preference to conventional chemotherapy as post-remission treatment for adults with lymphoblastic lymphoma. ( 29712994 )
2018
29
Secondary Thymoma among Adult Treated For Acute Lymphoblastic Lymphoma/Leukemia: Report of a Case and Review of the Literature. ( 30607194 )
2018
30
Bcl-2 maturation pattern in T-cells distinguishes thymic neoplasm/hyperplasia, T-lymphoblastic lymphoma, and reactive lymph nodes. ( 28718205 )
2018
31
Immunophenotypic analysis of adult patients with T-cell lymphoblastic lymphoma treated with hyper-CVAD. ( 28778131 )
2018
32
Myeloid Neoplasia and Lymphoblastic Lymphoma with Eosinophilia After Radioactive Iodine: A Case Report. ( 28958974 )
2018
33
Lymphoblastic Lymphoma Involving Multiple Vertebrae. ( 28962960 )
2018
34
Hyper-CVAD plus nelarabine in newly diagnosed adult T-cell acute lymphoblastic leukemia and T-lymphoblastic lymphoma. ( 29047158 )
2018
35
Outcome of pediatric patients with acute lymphoblastic leukemia/lymphoblastic lymphoma with hypersensitivity to pegaspargase treated with PEGylated Erwinia asparaginase, pegcrisantaspase: A report from the Children's Oncology Group. ( 29090524 )
2018
36
FGFR1 translocation with concurrent myeloproliferative neoplasm, systemic mastocytosis, and lymphoblastic lymphoma: a case report. ( 29107667 )
2018
37
Pediatric Patient With T-Cell Lymphoblastic Lymphoma and Acute Vision Loss. ( 29121170 )
2018
38
Case Report: A Cryptosporidium infection in a patient with relapsed T-lymphoblastic lymphoma undergoing allogeneic stem cell transplantation. ( 29140544 )
2018
39
Indolent T-lymphoblastic proliferation concomitant with acinic cell carcinoma mimicking T-lymphoblastic lymphoma: case report and literature review. ( 29143359 )
2018
40
Successful Treatment of Mediastinal γδ T-Cell Lymphoblastic Lymphoma in a 3-Year-Old Girl by Allogeneic Cord Blood Transplantation. ( 29200146 )
2018
41
Patients over 40 years old with precursor T-cell lymphoblastic lymphoma have different prognostic factors comparing to the youngers. ( 29348421 )
2018
42
Acute lymphoblastic leukemia and lymphoblastic lymphoma in adolescents and young adults. ( 29418064 )
2018
43
Antitumor effect of triptolide in T-cell lymphoblastic lymphoma by inhibiting cell viability, invasion, and epithelial-mesenchymal transition via regulating the PI3K/AKT/mTOR pathway. ( 29483777 )
2018
44
Myositis in bilateral calves mimicking lymphoma on interim PET/CT in a patient with T-lymphoblastic lymphoma. ( 29590432 )
2018
45
Precursor T-Lymphoblastic Lymphoma Associated with t(8;9)(p11.2;q33): A Case Report and Review of the Literature. ( 29614500 )
2018
46
Transformation of T-Cell Acute Lymphoblastic Lymphoma to Peripheral T-Cell Lymphoma: A Report of Two Cases. ( 29682368 )
2018
47
A case report of B lymphoblastic lymphoma with brain metastases: Clinical and pathological significance of head trauma misdiagnosis. ( 29768334 )
2018
48
Successful treatment of pulmonary invasive fungal infection by Penicillium non-marneffei in lymphoblastic lymphoma: case report and literature review. ( 29881585 )
2018
49
Terminal deoxynucleotidyl transferase (TdT)-negative T-cell lymphoblastic lymphoma with loss of the T-cell lineage-specific marker CD3 at relapse: a rare entity with an aggressive outcome. ( 29884716 )
2018
50
Philadelphia chromosome-positive lymphoblastic lymphoma-Is it rare or underdiagnosed? ( 29913129 )
2018

Variations for Lymphoblastic Lymphoma

Expression for Lymphoblastic Lymphoma

Search GEO for disease gene expression data for Lymphoblastic Lymphoma.

Pathways for Lymphoblastic Lymphoma

Pathways related to Lymphoblastic Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.17 BCL6 FLI1 MPO PTPRC TAL1
2 11.89 BCL6 FLI1 KMT2A MPO
3 11.44 CD5 CD7 DNTT MME
4 11.09 CD5 MME MPO NOTCH1 PTPRC
5 10.98 BCL6 CD5 MME PTPRC

GO Terms for Lymphoblastic Lymphoma

Biological processes related to Lymphoblastic Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of hematopoietic stem cell differentiation GO:1902036 9.4 KMT2A TAL1
2 cellular response to extracellular stimulus GO:0031668 9.37 CDKN2B PTPRC
3 embryonic hemopoiesis GO:0035162 9.32 KMT2A TAL1
4 megakaryocyte development GO:0035855 9.26 FLI1 TAL1
5 generation of neurons GO:0048699 9.16 FGFR1 TAL1
6 megakaryocyte differentiation GO:0030219 8.96 CDKN2B TAL1
7 regulation of cell proliferation GO:0042127 8.92 BCL6 FGFR1 NOTCH1 TAL1

Molecular functions related to Lymphoblastic Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.33 FGFR1 MPO PTPRC
2 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 9.13 FLI1 KMT2A TAL1
3 chromatin binding GO:0003682 9.02 BCL6 FLI1 MPO NOTCH1 TAL1

Sources for Lymphoblastic Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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