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MCID: LYM040
MIFTS: 53

Lymphoblastic Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Lymphoblastic Lymphoma

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MalaCards integrated aliases for Lymphoblastic Lymphoma:

Name: Lymphoblastic Lymphoma 12 73 20 15 37
Precursor Cell Lymphoblastic Leukemia Lymphoma 70
Precursor Cell Lymphoblastic Lymphoma 70
Lymphoma, Lymphoblastic 20
Lymphoma Lymphoblastic 54

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Immune diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:0080147
ICD10 32 C83.5
UMLS 70 C0079748 C1961102
Sources

Summaries for Lymphoblastic Lymphoma

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Disease Ontology : 12 A lymphoma that has material basis in immature malignant lymphocytes (lymphoblasts) committed to the B-cell or T-cell lineage and located in primarily lymph nodes or located in extranodal sites.

MalaCards based summary : Lymphoblastic Lymphoma, also known as precursor cell lymphoblastic leukemia lymphoma, is related to t-cell acute lymphoblastic leukemia and b-lymphoblastic leukemia/lymphoma. An important gene associated with Lymphoblastic Lymphoma is DNTT (DNA Nucleotidylexotransferase), and among its related pathways/superpathways are Transcriptional misregulation in cancer and NF-kappaB Signaling. The drugs Morphine and Idarubicin have been mentioned in the context of this disorder. Affiliated tissues include primarily lymph nodes, extranodal sites and t cells, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 73 Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the... more...

Sources

Related Diseases for Lymphoblastic Lymphoma

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Diseases related to Lymphoblastic Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 350)
# Related Disease Score Top Affiliating Genes
1 t-cell acute lymphoblastic leukemia 31.9 TAL1 RAG1 PTPRC NOTCH1 MYC LMO2
2 b-lymphoblastic leukemia/lymphoma 31.4 ZMYM2 PTPRC MYC MPO MME KMT2A
3 lymphoma, hodgkin, classic 30.9 TNFRSF8 PTPRC BCL6
4 ovarian lymphoma 30.6 MME BCL6
5 myeloproliferative neoplasm 30.6 ZMYM2 MPO KMT2A FGFR1 CEP85L
6 leukemia 30.6 TAL1 NOTCH1 MYC MME LMO2 KMT2A
7 lymphosarcoma 30.5 TNFRSF8 PTPRC BCL6
8 myeloid sarcoma 30.5 PTPRC MPO KMT2A DNTT
9 burkitt lymphoma 30.4 TNFRSF8 MYC MME DNTT CDKN2B BCL6
10 lymphoma 30.4 ZMYM2 TNFRSF8 TAL1 PTPRC MYC FGFR1
11 follicular lymphoma 30.4 MYC MME CD5 BCL6
12 precursor t-cell acute lymphoblastic leukemia 30.3 TAL1 NOTCH1 MYC MPO LMO2 KMT2A
13 adult acute lymphocytic leukemia 30.3 TNFRSF8 CDKN2B CD7
14 angioimmunoblastic t-cell lymphoma 30.2 TNFRSF8 MME BCL6
15 mixed phenotype acute leukemia 30.2 MPO KMT2A FGFR1 DNTT
16 b-cell lymphoma 30.2 TNFRSF8 PTPRC MYC MME CDKN2B CD5
17 pediatric lymphoma 30.2 TNFRSF8 MYC MME BCL6
18 primary cutaneous b-cell lymphoma 30.2 CDKN2B BCL6
19 ewing sarcoma 30.1 TNFRSF8 PTPRC MYC FLI1 DNTT CD99
20 leukemia, acute lymphoblastic 30.1 TNFRSF8 TAL1 RAG1 PTPRC NOTCH1 MYC
21 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 30.1 MPO KMT2A DNTT
22 t-cell non-hodgkin lymphoma 30.1 PTPRC NOTCH1
23 acute leukemia 30.1 TAL1 NOTCH1 MPO KMT2A FGFR1 DNTT
24 lymphoma, non-hodgkin, familial 30.1 ZMYM2 TNFRSF8 TAL1 RAG1 PTPRC NOTCH1
25 dendritic cell tumor 30.1 PTPRC MPO DNTT
26 peripheral t-cell lymphoma 30.0 TNFRSF8 PTPRC NOTCH1 MME CD5 BCL6
27 childhood leukemia 30.0 MPO KMT2A CDKN2B
28 hematologic cancer 30.0 TNFRSF8 NOTCH1 KMT2A FGFR1 DNTT CDKN2B
29 myelodysplastic syndrome 30.0 NOTCH1 MYC MPO KMT2A DNTT CDKN2B
30 t-cell adult acute lymphocytic leukemia 30.0 TNFRSF8 CD7 CD5
31 cll/sll 29.9 MME CD5 BCL6
32 lymphoplasmacytic lymphoma 29.9 MME CD5 BCL6
33 mantle cell lymphoma 29.9 PTPRC NOTCH1 MYC MME CDKN2B CD5
34 t-cell lymphoma, subcutaneous panniculitis-like 29.9 TNFRSF8 CD7
35 marginal zone b-cell lymphoma 29.8 TNFRSF8 MME CD5 BCL6
36 childhood acute lymphocytic leukemia 29.8 RAG1 PTPRC MME KMT2A DNTT CDKN2B
37 diffuse large b-cell lymphoma 29.8 TNFRSF8 PTPRC MYC MME LMO2 CD5
38 leukemia, chronic myeloid 29.8 TAL1 PTPRC MYC MPO KMT2A FGFR1
39 myeloma, multiple 29.7 PTPRC NOTCH1 MYC CD5 BCL6
40 composite lymphoma 29.6 TNFRSF8 MME CD5 BCL6
41 lymphoproliferative syndrome 29.6 TNFRSF8 PTPRC CD5 BCL6
42 t-cell lymphoblastic leukemia/lymphoma 29.6 TNFRSF8 TAL1 RAG1 PTPRC NOTCH1 MYC
43 immune deficiency disease 29.2 TNFRSF8 RAG1 PTPRC CD5 BCL6
44 acute promyelocytic leukemia 29.2 PTPRC NOTCH1 MYC MPO KMT2A CDKN2B
45 leukemia, chronic lymphocytic 28.9 TNFRSF8 PTPRC NOTCH1 MYC MME KMT2A
46 leukemia, acute myeloid 28.6 TNFRSF8 TAL1 PTPRC NOTCH1 MYC MPO
47 t-cell childhood lymphoblastic lymphoma 11.6
48 childhood t-cell acute lymphoblastic leukemia 11.1
49 chromosome 8p11 myeloproliferative syndrome 11.1
50 refractory t lymphoblastic leukemia/lymphoma 11.1

Graphical network of the top 20 diseases related to Lymphoblastic Lymphoma:



Diseases related to Lymphoblastic Lymphoma
Sources

Symptoms & Phenotypes for Lymphoblastic Lymphoma

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GenomeRNAi Phenotypes related to Lymphoblastic Lymphoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 9.93 PTPRC
2 Decreased viability GR00221-A-1 9.93 FGFR1 MYC
3 Decreased viability GR00221-A-2 9.93 FGFR1
4 Decreased viability GR00221-A-3 9.93 MYC
5 Decreased viability GR00249-S 9.93 MYC
6 Decreased viability GR00386-A-1 9.93 CD5 FGFR1 NOTCH1
7 Decreased viability GR00402-S-2 9.93 KMT2A MYC TNFRSF8
8 Reduced mammosphere formation GR00396-S 9.28 BCL6 CD5 CD7 KMT2A LMO2 MYC
9 Increased the percentage of infected cells GR00402-S-1 8.65 CD99

MGI Mouse Phenotypes related to Lymphoblastic Lymphoma:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.39 BCL6 CD5 CD7 CDKN2B DNTT FGFR1
2 hematopoietic system MP:0005397 10.38 BCL6 CD5 CD7 CDKN2B DNTT FGFR1
3 cardiovascular system MP:0005385 10.31 BCL6 FGFR1 FLI1 KMT2A LMO2 MME
4 cellular MP:0005384 10.3 BCL6 CDKN2B FGFR1 FLI1 KMT2A LMO2
5 endocrine/exocrine gland MP:0005379 10.21 BCL6 CD7 CDKN2B FGFR1 FLI1 MYC
6 integument MP:0010771 10.21 BCL6 CD5 CDKN2B FGFR1 KMT2A LMO2
7 mortality/aging MP:0010768 10.18 BCL6 CDKN2B FGFR1 FLI1 KMT2A LMO2
8 liver/biliary system MP:0005370 10.06 BCL6 FLI1 KMT2A LMO2 MME MYC
9 nervous system MP:0003631 10 CD5 FGFR1 FLI1 KMT2A LMO2 MME
10 hearing/vestibular/ear MP:0005377 9.97 CEP85L FGFR1 KMT2A MYC NOTCH1 RAG1
11 neoplasm MP:0002006 9.92 CDKN2B FLI1 KMT2A LMO2 MYC NOTCH1
12 no phenotypic analysis MP:0003012 9.7 BCL6 CD5 CDKN2B FGFR1 KMT2A MYC
13 normal MP:0002873 9.61 BCL6 CD5 DNTT FGFR1 KMT2A MYC
14 renal/urinary system MP:0005367 9.23 CDKN2B FGFR1 KMT2A LMO2 NOTCH1 PTPRC
Sources

Drugs & Therapeutics for Lymphoblastic Lymphoma

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Drugs for Lymphoblastic Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 502)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Morphine Approved, Investigational Phase 4 57-27-2 5288826
2
Idarubicin Approved Phase 4 58957-92-9 42890
3
Nicotine Approved Phase 4 54-11-5 942 89594
4
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
7
Vincristine Approved, Investigational Phase 4 2068-78-2, 57-22-7 5978
8
Cytarabine Approved, Investigational Phase 4 147-94-4 6253
9
Cyclophosphamide Approved, Investigational Phase 4 50-18-0, 6055-19-2 2907
10
Etoposide Approved Phase 4 33419-42-0 36462
11
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
12
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
13
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
14
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
15
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
16
Daunorubicin Approved Phase 4 20830-81-3 30323
17
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
18
Mercaptopurine Approved Phase 4 50-44-2 667490
19
Vindesine Approved, Investigational Phase 4 59917-39-4, 53643-48-4 40839
20
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
21
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
22
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
23
Mitoxantrone Approved, Investigational Phase 4 65271-80-9 4212
24
Micafungin Approved, Investigational Phase 4 235114-32-6 3081921 477468
25
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
26
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
27
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
28
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
29
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
30
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
31
Calcifediol Approved, Nutraceutical Phase 4 19356-17-3 5283731 6433735
32
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
33
Ethylene Phase 4 74-85-1 6325
34 Antibiotics, Antitubercular Phase 4
35 Antirheumatic Agents Phase 4
36 Immunosuppressive Agents Phase 4
37 Alkylating Agents Phase 4
38 Immunologic Factors Phase 4
39 Anti-Infective Agents Phase 4
40 Anti-Bacterial Agents Phase 4
41 Etoposide phosphate Phase 4
42 Dermatologic Agents Phase 4
43 Antimetabolites Phase 4
44 Vitamin B9 Phase 4
45 Tubulin Modulators Phase 4
46 Gastrointestinal Agents Phase 4
47 Methylprednisolone Acetate Phase 4
48 Folate Phase 4
49 Vitamin B Complex Phase 4
50 Folic Acid Antagonists Phase 4

Interventional clinical trials:

(show top 50) (show all 1530)
# Name Status NCT ID Phase Drugs
1 A Clinical Trial of Decitabine Combined With CODOX-M/IVAC in Relapsed or Refractory T-lymphoblastic Lymphoma Unknown status NCT03558412 Phase 4 Decitabine
2 Multicenter Study To Optimize Treatment in Elderly Patients (> 55 Years, No Upper Age Limit) With Acute Lymphoblastic Leukemia (GMALL Elderly 1/2003)(Amend 2) Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
3 An Open-label,Multi-center,Prospective Study of Idarubicin and Etoposide Intensified Conditioning Regimen Allogeneic Hematopoietic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
4 PEG-asparaginase During Two Treatment Courses in the Treatment of Childhood Acute Lymphoblastic Leukemia Unknown status NCT00192673 Phase 4 PEG-asparaginase
5 Plasma Kinetics of Tablet and Liquid Formulations of 6-mercaptopurine in Childhood Acute Lymphoblastic Leukemia. Unknown status NCT01906671 Phase 4 Xaluprine;Puri-Nethol
6 Medical Research Council Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
7 German Multicenter Study for Treatment Optimisation in Acute Lymphoblastic Leukemia in Adults and Adolescents Above 15 Years (Amend 3) (GMALL 07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
8 G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor: a Prospective, Multicentre, Randomised Controlled Trial Unknown status NCT02933333 Phase 4
9 Clinical Study of GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia in Guangdong Province Unknown status NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
10 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
11 Ma-Spore ALL 2010 Study Unknown status NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
12 The Combination of Lower Dosage of Chemotherapy With Tyrosine Kinase Inhibitor to Treat Newly Diagnosed ph+ Acute Lymphoblastic Leukemia Patients Unknown status NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
13 Philadelphia -Negative High-risk Children Acute Lymphoblastic Leukemia(ALL) Treatment:Induction Therapy:Vincristine(V),Idarubicin(I),L-asparaginase(L),Dexamethasone(D);Consolidation:V+Daunorubicin(D)+L+D, Methotrexate,Cytarabine Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
14 Multicenter Trial for Treatment Optimization in T-lymphoblastic Lymphoma in Adults and Adolescents Older Than 15 Years (GMALL T-LBL 1/2004) (Amend 1) Completed NCT00199017 Phase 4 Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
15 Pulses of Vincristine and Dexamethasone During Maintenance in BFM Protocols for Children With Intermediate-Risk Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
16 Multicenter Trial for Treatment of Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
17 Multicenter Trial for Treatment of Acute Lymphocytic Leukemia in Adults (Pilot Study 06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
18 German Multicenter Trial for Treatment Optimisation in Acute Lymphoblastic Leukemia in Adults and Adolescents Above 15 Years With Rituximab for Improvement of Prognosis in CD20 Positive Standard Risk ALL (Amend 2) Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
19 ALL-REZ BFM 2002: Protocol for the Treatment of Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
20 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin;Mercaptopurine;Prednisone;Vincristine;Methotrexate
21 A Randomized Open-Label Trial of Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Completed NCT01200355 Phase 4 micafungin;posaconazole
22 The Study on the Pharmacokinetics of Pegylated Recombinant Human Granulocyte Stimulating Factor（PEG-rhG-CSF） in Children and Adolescents Completed NCT02953730 Phase 4 PEG-rhG-CSF
23 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 (Stoss Therapy) in Pediatric Patients Undergoing HSCT to Prevent Vitamin D Deficiency and Insufficiency During Transplant Completed NCT03176849 Phase 4
24 Pilot Study for Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
25 Multicenter Study to Optimise Therapy of B-ALL, Burkitt's NHL and High-Grade Non-Hodgkin's Lymphoma in Adults (Amend 7) Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
26 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4 Methylphenidate
27 Prospective Study of Rituximab Combined With Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
28 Treatment of High Risk Adult Acute Lymphoblastic Leukemia Completed NCT00853008 Phase 4 Vincristine;Daunorubicin;Prednisone;Mitoxantrone;Cytosine Arabinoside;Dexamethasone;Methotrexate (MTX);Cytarabine;ASP;Mercaptopurine;Teniposide;Hydrocortisone
29 Vaccinating Children After Chemotherapy for Acute Lymphoblastic Leukemia: A Canadian Immunization Research Network Study Completed NCT02447718 Phase 4
30 LAL-AR-N-2005: Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4 Prednisolone;Daunorubicin;Vincristine;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside
31 LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive Completed NCT00526305 Phase 4 Vincristine;Daunorubicin;Prednisone;L-Asparaginase;Mitoxantrone;Cytosine Arabinoside;Hydrocortisone;Mercaptopurine;Cyclophosphamide;Dexamethasone
32 LAL-BR/2001: Study Treatment to Low Risk ALL Completed NCT00526175 Phase 4 Prednisone;Vincristine;Daunorubicin;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside;Mercaptopurine;VP-16
33 Hematology , Shanghai Jiaotong University Affiliated Shanghai First People's Hospital, Shanghai, China Recruiting NCT02938741 Phase 4 Anti-human Thymoglobulin;Placebo
34 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
35 A PHASE 4, OPEN-LABEL, RANDOMIZED STUDY OF TWO INOTUZUMAB OZOGAMICIN DOSE LEVELS IN ADULT PATIENTS WITH RELAPSED OR REFRACTORY B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA ELIGIBLE FOR HEMATOPOIETIC STEM CELL TRANSPLANTATION AND WHO HAVE RISK FACTOR(S) FOR VENO-OCCLUSIVE DISEASE Recruiting NCT03677596 Phase 4 inotuzumab ozogamicin-dose level 2;Inotuzumab ozogamicin-dose level 1
36 PROTOCOL FOR THE TREATMENT Acute Lymphoblastic Leukemia With Ph 'NEGATIVE IN ELDERLY PATIENTS (> 55 Years) Recruiting NCT01366898 Phase 4 Dexamethasona, Idarubicine, ARA-C, Methotrexate
37 Allogeneic Stem Cell Transplant for Children and Adolescents With Acute Lymoblastic Leukemia FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
38 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
39 Treatment Protocol For All Fragile Patients Ph' Negative Over 55 Years Recruiting NCT01358201 Phase 4 vINCRISTINE;Dexamethasone;Methotrexate;Cytosine arabinoside
40 Determinants of Mercaptopurine Toxicity in Paediatric Acute Lymphoblastic Enrolling by invitation NCT03920813 Phase 4 Mercaptopurine
41 A Phase 4, Multi-center Open-label Feasibility Study to Evaluate Outpatient Blinatumomab Administration in Adult Subjects With Minimal Residual Disease (MRD) of B-precursor Acute Lymphoblastic Leukemia (ALL) in Complete Hematologic Remission Not yet recruiting NCT04506086 Phase 4 Blinatumomab
42 ProphyALL - Pilot Study on Safety of Four Weekly Administrations of 7 mg/kg of Liposomal Amphotericin B (AmBisome®) in Antifungal Primary Prophylaxis Treatment of Elderly Patients With Acute Lymphoblastic Leukemia Undergoing Induction Chemotherapy Within the GMALL-Elderly Protocol Terminated NCT00386997 Phase 4 liposomal amphotericin B (AmBisome®)
43 A Phase III Randomized Trial of G-CSF Stimulated Bone Marrow vs. Conventional Bone Marrow as a Stem Cell Source In Matched Sibling Donor Transplantation Unknown status NCT00450450 Phase 3
44 The Value of Dexamethasone Versus Prednisolone During Induction and Maintenance Therapy of Prolonged Versus Conventional Duration of L-Asparaginase Therapy During Consolidation and Late Intensification, and of Corticosteroid + VCR Pulses During Maintenance in Acute Lymphoblastic Leukemia and Lymphoblastic Non-Hodgkin Lymphoma of Childhood Unknown status NCT00003728 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisolone;therapeutic hydrocortisone;thioguanine;vincristine sulfate;vindesine
45 An Open-Label, One-Arm, Multi-Site Trial of Precision Diagnosis Directing Target Total Therapy for Adult Ph-like Acute Lymphoblastic Leukemia Unknown status NCT03564470 Phase 2, Phase 3 Chidamide;Dasatinib
46 Randomized Study of Atorvastatin Prophylaxis as a Supplement to Standard of Care Prophylaxis to Prevent Chronic Graft Versus Host Disease Allogeneic Stem Cell Transplantation From Matched Unrelated Donors Unknown status NCT03066466 Phase 3 Atorvastatin;Methotrexate;Tacrolimus
47 CART-19 Cells For Patients With Minimal Residual Disease (MRD) Positive CD19+ Acute Lymphoblastic Leukemia Unknown status NCT03027739 Phase 2, Phase 3
48 Evaluation of a Donor Testing Kit for the Prediction of Acute GVHD in Patient Receiving a Peripheral Blood Stem Cells Allograft- Predictor 2 Unknown status NCT03887156 Phase 2, Phase 3
49 A Phase-2 Clinical Study to Determine the Efficacy and Safety of Depocyt (Cytarabine Liposome Injection) for the Treatment of CNS Relapse in Adult Patients With Acute Lymphoblastic Leukemia or Very Aggressive Lymphoma Unknown status NCT00199108 Phase 2, Phase 3 Depocyt;Dexamethasone
50 Randomized Controlled Trial to Test Efficacy of High-Dose Methotrexate Consolidation Therapy for BCR-ABL-Negative Acute Lymphoblastic Leukemia in Adults Unknown status NCT00131027 Phase 3 Cyclophosphamide;Daunorubicin;Vincristine;Prednisolone;L-asparaginase;Cytarabine;Etoposide;Dexamethasone;Methotrexate;Mercaptopurine;Doxorubicin;Methotrexate

Search NIH Clinical Center for Lymphoblastic Lymphoma

Inferred drug relations via UMLS 70 / NDF-RT 51 :


ASPARAGINASE
Cyclophosphamide
Idarubicin
Idarubicin Hydrochloride
Ifosfamide
mercaptopurine
pegaspargase
sargramostim

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Lymphoblastic Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Lymphoblastic Lymphoma:
Blood stem cell transplantation for hematological diseases
Hematopoietic stem cells for treatment of hematologic malignancies
Peripheral blood stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Lymphoblastic Lymphoma:
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived hematopoietic stem cells
Sources

Genetic Tests for Lymphoblastic Lymphoma

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Sources

Anatomical Context for Lymphoblastic Lymphoma

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The Foundational Model of Anatomy Ontology organs/tissues related to Lymphoblastic Lymphoma:

19
Primarily Lymph Nodes, Extranodal Sites

MalaCards organs/tissues related to Lymphoblastic Lymphoma:

40
T Cells, Myeloid, Bone Marrow, Bone, Nk Cells, Breast, Kidney
Sources

Publications for Lymphoblastic Lymphoma

About this section

Articles related to Lymphoblastic Lymphoma:

(show top 50) (show all 2079)
# Title Authors PMID Year
1
Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of t(14;18)-negative follicular lymphoma. 54 61
19633642 2009
2
Immunohistochemical evaluation of FLI-1 in acute lymphoblastic lymphoma (ALL): a potential diagnostic pitfall. 54 61
19349856 2009
3
PAX immunoreactivity identifies alveolar rhabdomyosarcoma. 54 61
19145202 2009
4
K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors. 54 61
18663146 2008
5
Reactivity with TdT in Merkel cell carcinoma: a potential diagnostic pitfall. 54 61
18480005 2008
6
A six-year-old boy with a suspicious thyroid nodule: intrathyroidal thymic tissue. 54 61
18341382 2008
7
TdT expression in Merkel cell carcinoma: potential diagnostic pitfall with blastic hematological malignancies and expanded immunohistochemical analysis. 61 54
17885674 2007
8
CD26, together with cell surface adenosine deaminase, is selectively expressed on ALK-positive, but not on ALK-negative, anaplastic large cell lymphoma and Hodgkin's lymphoma. 54 61
17071493 2006
9
Primary malignant lymphoma of the central nervous system in an immunocompetent child: a case report. 61 54
16217262 2005
10
[NSE-positive lymphoblastic lymphoma in a boy with cutaneous involvement, giant splenomegaly, and hyper-gamma globulinemia]. 61 54
15678916 2004
11
Methylation status of cyclin-dependent kinase inhibitor genes within the transforming growth factor beta pathway in human T-cell lymphoblastic lymphoma/leukemia. 61 54
15475071 2004
12
[Pathologic diagnoses of core needle biopsies of the mediastinum]. 54 61
15132850 2004
13
CD26 expression correlates with a reduced sensitivity to 2'-deoxycoformycin-induced growth inhibition and apoptosis in T-cell leukemia/lymphomas. 54 61
14760072 2004
14
Immunohistochemical expression of the transcription factor DP-1 and its heterodimeric partner E2F-1 in non-Hodgkin lymphoma. 61 54
12607600 2002
15
The 8p11 myeloproliferative syndrome: a distinct clinical entity caused by constitutive activation of FGFR1. 54 61
11919391 2002
16
Peripheral T-cell lymphoma with aberrant expression of CD79a and CD20: a diagnostic pitfall. 54 61
11235901 2001
17
BCL-6 protein is expressed in precursor T-cell lymphoblastic lymphoma and in prenatal and postnatal thymus. 54 61
11133771 2001
18
Ewing sarcoma vs lymphoblastic lymphoma. A comparative immunohistochemical study. 61 54
11190795 2001
19
Therapy-related T cell lymphoblastic lymphoma with t(11;19)(q23;p13) and MLL gene rearrangement. 54 61
10602439 1999
20
Lymphoblastic lymphoma expressing CD56 and TdT. 54 61
9422326 1998
21
MIC2, TdT, bcl-2, and CD34 expression in paraffin-embedded high-grade lymphoma/acute lymphoblastic leukemia distinguishes between distinct clinicopathologic entities. 54 61
9343323 1997
22
An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice. 61 54
9171354 1997
23
Terminal deoxynucleotidyl transferase staining of malignant lymphomas in paraffin sections: a useful method for the diagnosis of lymphoblastic lymphoma. 54 61
9227346 1997
24
Defects of the mismatch repair gene MSH2 are implicated in the development of murine and human lymphoblastic lymphomas and are associated with the aberrant expression of rhombotin-2 (Lmo-2) and Tal-1 (SCL). 61 54
9116269 1997
25
Application of rearrangements of T cell receptor gene in the diagnosis of mediastinal T-lymphoblastic lymphoma: a case report. 61 54
9175304 1997
26
Lymphoblastic lymphoma expressing natural killer cell phenotype with involvement of the mediastinum and nasal cavity. 61 54
9042293 1997
27
A T cell lymphoblastic lymphoma patient with two malignant cell populations carrying different 9p deletions including the p16INK4 and p15INK4B genes: Clinical response to interferon-alpha therapy in one of the subclones. 61 54
8656689 1996
28
Expression pattern of CD45 RA/RO isoformic antigens in T-lineage neoplasms. 61 54
7741140 1995
29
Involvement of CDKN2 (p16INK4A/MTS1) and p15INK4B/MTS2 in human leukemias and lymphomas. 54 61
7882348 1995
30
Terminal deoxynucleotidyl transferase staining of malignant lymphomas in paraffin sections. 54 61
7937725 1994
31
Lineage determination of CD7+ CD5- CD2- and CD7+ CD5+ CD2- lymphoblasts: studies on phenotype, genotype, and gene expression of myeloperoxidase, CD3 epsilon, and CD3 delta. 54 61
7513945 1994
32
Small cell osteosarcoma of bone: an immunohistochemical study with differential diagnostic considerations. 54 61
7503935 1993
33
Human recombination activating gene-1 in leukemia/lymphoma cells: expression depends on stage of lymphoid differentiation defined by phenotype and genotype. 54 61
8391873 1993
34
Emergence of a B-cell lymphoblastic lymphoma in a patient with B-cell chronic lymphocytic leukemia: evidence for the single-cell origin of the two tumors. 54 61
1859892 1991
35
Flow cytometric analysis of terminal deoxynucleotidyl transferase. 61 54
1996546 1991
36
Expression of enolases in T cell tumors and Hodgkin's disease. 61 54
2255187 1990
37
Genuine CD7 expression in acute leukemia and lymphoblastic lymphoma. 61 54
1701841 1990
38
Diffuse large B cell lymphoma presenting with renal failure and bone lesions in a 46-year-old woman: a case report and review of literature. 61
32989684 2021
39
Lymphoreticular malignancies in serous effusions: Cytomorphologic, flow cytometric and immunocytochemical analysis. 61
33629825 2021
40
A case of primary cutaneous B-cell lymphoma with immature features in an old man. Diffuse large B-cell lymphoma with immature features or B-cell lymphoblastic lymphoma? 61
32623764 2021
41
Utility of 18F-FDG-PET/CT in lymphoblastic lymphoma. 61
33275056 2021
42
Mediastinal Gamma-Delta T-Cell Lymphoblastic Lymphoma Successfully Treated With Chemotherapy Alone. 61
33370002 2021
43
Multiple Primary Osseous B-Lymphoblastic Lymphoma/Leukemia Shown on Bone Scintigraphy. 61
33795591 2021
44
Primary Paraspinal and Spinal Epidural Non-Hodgkin Lymphoma in Childhood. 61
32520843 2021
45
Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities. 61
33063290 2021
46
B-cell lymphoblastic lymphoma of unilateral primary breast mass in a boy aged 11 years. 61
33527573 2021
47
Primary and isolated cutaneous precursor B-lymphoblastic lymphoma in an infant. 61
33738831 2021
48
Intensive chemotherapy and sequential hematopoietic stem cell transplantation: Is it necessary for high-risk T-cell lymphoblastic lymphoma? 61
33605562 2021
49
Altered FDG Biodistribution in Subcutaneous White Fat on PET/CT Following l-Asparaginase Chemotherapy. 61
33086270 2021
50
A single assessment of methotrexate levels at 42 hours permits safe administration and early discharge in children with lymphoblastic lymphoma and leukemia receiving high-dose methotrexate. 61
33764242 2021
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Variations for Lymphoblastic Lymphoma

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Expression for Lymphoblastic Lymphoma

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Search GEO for disease gene expression data for Lymphoblastic Lymphoma.
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Pathways for Lymphoblastic Lymphoma

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Pathways related to Lymphoblastic Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Transcriptional misregulation in cancer 36
11.72 MYC MPO LMO2 KMT2A FLI1 BCL6
2
NF-kappaB Signaling 4
11.68 TNFRSF8 TAL1 RAG1 PTPRC MPO FLI1
3
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.62 PTPRC NOTCH1 MPO MME CD5
4
Neural Crest Differentiation 1
11.59 NOTCH1 MYC FGFR1
5
Hematopoietic cell lineage 36
11.55 MME DNTT CD7 CD5
6
Validated targets of C-MYC transcriptional repression 1
11.33 MYC DNTT CDKN2B
7
Hematopoietic Stem Cell Differentiation 1
11.18 NOTCH1 LMO2 FLI1
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GO Terms for Lymphoblastic Lymphoma

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Biological processes related to Lymphoblastic Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 9.43 RAG1 PTPRC BCL6
2 embryonic hemopoiesis GO:0035162 9.4 TAL1 KMT2A
3 megakaryocyte development GO:0035855 9.37 TAL1 FLI1
4 cellular response to extracellular stimulus GO:0031668 9.32 PTPRC CDKN2B
5 positive regulation of transcription by RNA polymerase II GO:0045944 9.17 TAL1 NOTCH1 MYC LMO2 KMT2A FLI1
6 megakaryocyte differentiation GO:0030219 9.16 TAL1 CDKN2B
7 regulation of hematopoietic stem cell differentiation GO:1902036 9.13 TAL1 LMO2 KMT2A

Molecular functions related to Lymphoblastic Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.62 ZMYM2 TNFRSF8 TAL1 RAG1 PTPRC NOTCH1
2 chromatin binding GO:0003682 9.35 TAL1 NOTCH1 MPO FLI1 BCL6
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Sources for Lymphoblastic Lymphoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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