MCID: LYM040
MIFTS: 53

Lymphoblastic Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases
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Aliases & Classifications for Lymphoblastic Lymphoma

MalaCards integrated aliases for Lymphoblastic Lymphoma:

Name: Lymphoblastic Lymphoma 11 19 75 14 36
Precursor Cell Lymphoblastic Leukemia Lymphoma 71
Precursor Cell Lymphoblastic Lymphoma 71
Lymphoma, Lymphoblastic 19
Lymphoma Lymphoblastic 53

Classifications:



External Ids:

Disease Ontology 11 DOID:0080147
ICD10 31 C83.5
UMLS 71 C0079748 C1961102

Summaries for Lymphoblastic Lymphoma

Disease Ontology: 11 A lymphoma that has material basis in immature malignant lymphocytes (lymphoblasts) committed to the B-cell or T-cell lineage and located in primarily lymph nodes or located in extranodal sites.

MalaCards based summary: Lymphoblastic Lymphoma, also known as precursor cell lymphoblastic leukemia lymphoma, is related to b-lymphoblastic leukemia/lymphoma and childhood t-cell acute lymphoblastic leukemia. An important gene associated with Lymphoblastic Lymphoma is DNTT (DNA Nucleotidylexotransferase), and among its related pathways/superpathways are Hematopoietic Stem Cells and Lineage-specific Markers and NF-kappaB Signaling. The drugs Lenograstim and Morphine have been mentioned in the context of this disorder. Affiliated tissues include primarily lymph nodes, extranodal sites and t cells, and related phenotypes are nervous system and growth/size/body region

GARD: 19 A lymphoma composed of immature small to medium-sized precursor lymphoid cells (lymphoblasts). It includes the B- and T-cell lymphoblastic lymphoma.

Wikipedia: 75 Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the... more...

Related Diseases for Lymphoblastic Lymphoma

Diseases related to Lymphoblastic Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 404)
# Related Disease Score Top Affiliating Genes
1 b-lymphoblastic leukemia/lymphoma 32.1 PTPRC PAX5 DNTT CDKN2B CD7
2 childhood t-cell acute lymphoblastic leukemia 31.9 TAL1 LMO2 CD7
3 t-cell acute lymphoblastic leukemia 31.3 TNFRSF8 TAL1 RAG1 PTPRC NOTCH1 LMO2
4 burkitt lymphoma 31.3 TNFRSF8 PAX5 DNTT CDKN2B BCL6 BCL2
5 precursor t-cell acute lymphoblastic leukemia 30.9 TAL1 NOTCH1 LMO2 DNTT CDKN2B CD7
6 leukemia, acute lymphoblastic 30.8 TAL1 RAG1 PTPRC PAX5 NOTCH1 LMO2
7 lymphoma 30.8 ZMYM2 TNFRSF8 TAL1 PTPRC PAX5 FGFR1
8 lymphoma, hodgkin, classic 30.8 TNFRSF8 RAG1 PTPRC PAX5 BCL6 BCL2
9 leukemia 30.7 ZMYM2 TAL1 NOTCH1 LMO2 FLI1 FGFR1
10 thymoma 30.7 PTPRC DNTT CD8A BCL2
11 ovarian lymphoma 30.6 DNTT BCL6 BCL2
12 myeloid sarcoma 30.4 TNFRSF8 PTPRC DNTT CD7
13 mediastinal cancer 30.4 TNFRSF8 PAX5
14 lymphosarcoma 30.4 TNFRSF8 BCL6 BCL2
15 diffuse large b-cell lymphoma 30.4 TNFRSF8 PAX5 BCL6 BCL2
16 ewing sarcoma 30.4 TNFRSF8 PTPRC FLI1 FGFR1 DNTT CD99
17 acute biphenotypic leukemia 30.3 PAX5 DNTT CD7
18 thymus cancer 30.3 PTPRC DNTT CD8A BCL2
19 testicular lymphoma 30.2 TNFRSF8 BCL6 BCL2
20 acute leukemia 30.2 TAL1 PAX5 DNTT CDKN2B CD8A CD7
21 b-cell lymphoma 30.2 TNFRSF8 PTPRC PAX5 CDKN2B CDKN1B BCL6
22 lymphoproliferative syndrome 30.2 TNFRSF8 BCL6 BCL2
23 breast lymphoma 30.2 TNFRSF8 PAX5 BCL6 BCL2
24 leukemia, chronic myeloid 30.1 TAL1 PTPRC NOTCH1 FGFR1 DNTT CDKN2B
25 hematologic cancer 30.1 TNFRSF8 PAX5 NOTCH1 FGFR1 DNTT CDKN2B
26 adult t-cell leukemia/lymphoma 30.1 TNFRSF8 CD8A CD7 BCL2
27 mycosis fungoides 30.0 TNFRSF8 CDKN2B CD7 BCL2
28 t-cell adult acute lymphocytic leukemia 30.0 TNFRSF8 CD8A CD7
29 anaplastic large cell lymphoma 30.0 TNFRSF8 PTPRC PAX5 CDKN1B BCL2
30 myelodysplastic syndrome 30.0 PTPRC FGFR1 DNTT CDKN2B CD8A CD7
31 childhood lymphoma 30.0 TNFRSF8 PAX5 DNTT BCL6 BCL2
32 breast implant-associated anaplastic large cell lymphoma 30.0 TNFRSF8 CD7
33 lymphatic system disease 29.9 TNFRSF8 CD8A BCL6 BCL2
34 marginal zone b-cell lymphoma 29.9 TNFRSF8 PAX5 BCL6 BCL2
35 lymphoplasmacytic lymphoma 29.9 PAX5 BCL6 BCL2
36 mediastinal malignant lymphoma 29.9 TNFRSF8 PAX5
37 primary cutaneous t-cell non-hodgkin lymphoma 29.9 TNFRSF8 CDKN2B CD7
38 peripheral t-cell lymphoma 29.8 TNFRSF8 PTPRC PAX5 CD8A CD7 BCL6
39 mantle cell lymphoma 29.8 TNFRSF8 PTPRC PAX5 NOTCH1 CD8A BCL6
40 angioimmunoblastic t-cell lymphoma 29.8 TNFRSF8 PAX5 CD8A CD7 BCL6
41 peripheral nervous system disease 29.8 TNFRSF8 PTPRC NOTCH1 CD8A BCL2
42 wilms tumor 1 29.7 PTPRC NOTCH1 CD99 CD8A BCL2
43 composite lymphoma 29.7 TNFRSF8 PAX5 BCL6 BCL2
44 chronic lymphocytic leukemia/small lymphocytic lymphoma 29.7 TNFRSF8 PAX5 BCL6 BCL2
45 central nervous system lymphoma 29.7 TNFRSF8 PAX5 BCL6 BCL2
46 adult acute lymphocytic leukemia 29.6 TNFRSF8 TAL1 PAX5 CDKN2B CD8A CD7
47 nervous system disease 29.6 PTPRC NOTCH1 FGFR1 DNTT CDKN2B CDKN1B
48 acute promyelocytic leukemia 29.4 PTPRC NOTCH1 DNTT CDKN2B CDKN1B CD7
49 skin disease 29.4 TNFRSF8 PTPRC NOTCH1 CD8A CD7 BCL2
50 lymphoma, non-hodgkin, familial 29.4 ZMYM2 TNFRSF8 TAL1 RAG1 PTPRC PAX5

Graphical network of the top 20 diseases related to Lymphoblastic Lymphoma:



Diseases related to Lymphoblastic Lymphoma

Symptoms & Phenotypes for Lymphoblastic Lymphoma

GenomeRNAi Phenotypes related to Lymphoblastic Lymphoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.19 BCL2 BCL6 CD7 CD8A CDKN1B CDKN2B
2 no effect GR00402-S-2 10.19 BCL2 BCL6 CD7 CD99 CDKN1B CDKN2B

MGI Mouse Phenotypes related to Lymphoblastic Lymphoma:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.27 BCL2 CD8A CDKN1B CEP85L FGFR1 FLI1
2 growth/size/body region MP:0005378 10.25 BCL2 BCL6 CDKN1B CEP85L FGFR1 FGFR1OP2
3 renal/urinary system MP:0005367 10.22 BCL2 CD8A CDKN1B CDKN2B CEP85L FGFR1
4 immune system MP:0005387 10.21 BCL2 BCL6 CD7 CD8A CD99 CDKN1B
5 endocrine/exocrine gland MP:0005379 10.18 BCL2 BCL6 CD7 CD8A CDKN1B CDKN2B
6 cellular MP:0005384 10.18 BCL2 BCL6 CD8A CDKN1B CDKN2B FGFR1
7 neoplasm MP:0002006 10.16 BCL2 CDKN1B CDKN2B FLI1 LMO2 NOTCH1
8 hematopoietic system MP:0005397 10.09 BCL2 BCL6 CD7 CD8A CD99 CDKN1B
9 cardiovascular system MP:0005385 10.06 BCL2 BCL6 CDKN1B FGFR1 FGFR1OP2 FLI1
10 hearing/vestibular/ear MP:0005377 10 BCL2 CDKN1B CEP85L FGFR1 NOTCH1 PAX5
11 pigmentation MP:0001186 9.92 BCL2 CDKN1B NOTCH1 RAG1 TAL1
12 mortality/aging MP:0010768 9.83 BCL2 BCL6 CD8A CDKN1B CDKN2B FGFR1
13 integument MP:0010771 9.44 BCL2 BCL6 CD8A CDKN1B CDKN2B CEP85L

Drugs & Therapeutics for Lymphoblastic Lymphoma

Drugs for Lymphoblastic Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 523)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenograstim Approved, Investigational Phase 4 135968-09-1
2
Morphine Approved, Investigational Phase 4 57-27-2 5288826
3
Sargramostim Approved, Investigational Phase 4 123774-72-1
4
Nicotine Approved Phase 4 54-11-5 942 89594
5
Cladribine Approved, Investigational Phase 4 4291-63-8 20279
6
Teniposide Approved Phase 4 29767-20-2 34698 452548
7
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
8
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
9
Posaconazole Approved, Investigational, Vet_approved Phase 4 171228-49-2 147912
10
Micafungin Approved, Investigational Phase 4 235114-32-6 477468
11
Idarubicin Approved Phase 4 58957-92-9 42890
12
Treosulfan Approved, Investigational Phase 4 299-75-2 9296
13
Simvastatin Approved Phase 4 79902-63-9 54454
14
Acetylcysteine Approved, Investigational Phase 4 616-91-1 581 12035
15
Cholecalciferol Approved, Nutraceutical, Vet_approved Phase 4 67-97-0, 1406-16-2 5280795 10883523
16
Calcifediol Approved, Nutraceutical Phase 4 19356-17-3 5283731
17
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
18
Molgramostim Investigational Phase 4 99283-10-0
19 Adjuvants, Immunologic Phase 4
20
Ethylene Phase 4 74-85-1 6325
21 Neurotransmitter Agents Phase 4
22 Calciferol Phase 4
23 Central Nervous System Stimulants Phase 4
24 Dopamine Uptake Inhibitors Phase 4
25 Dopamine Agents Phase 4
26 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
27 Antiprotozoal Agents Phase 4
28 Antiparasitic Agents Phase 4
29 Cytochrome P-450 Enzyme Inhibitors Phase 4
30
Vitamin D2 Phase 4 3249
31 Ergocalciferols Phase 4
32 Hydroxycholecalciferols Phase 4
33 Hypolipidemic Agents Phase 4
34 Anticholesteremic Agents Phase 4
35 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
36 Lipid Regulating Agents Phase 4
37 Respiratory System Agents Phase 4
38 Antioxidants Phase 4
39 Expectorants Phase 4
40 N-monoacetylcystine Phase 4
41
Lorazepam Approved Phase 3 846-49-1 3958
42
Pentoxifylline Approved, Investigational Phase 2, Phase 3 6493-05-6 4740
43
Sirolimus Approved, Investigational Phase 3 53123-88-9 5284616 6436030
44
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 4112 126941
45
Risedronic acid Approved, Investigational Phase 3 105462-24-6 5245
46
Etidronic acid Approved Phase 3 2809-21-4, 7414-83-7 3305
47
Epirubicin Approved Phase 3 56420-45-2 41867
48
Carvedilol Approved, Investigational Phase 3 72956-09-3 2585
49
Enalaprilat Approved Phase 3 76420-72-9 6917719 5462501
50
Enalapril Approved, Vet_approved Phase 3 75847-73-3 40466924 5388962 5362032

Interventional clinical trials:

(show top 50) (show all 1714)
# Name Status NCT ID Phase Drugs
1 A Clinical Trial of Decitabine Combined With CODOX-M/IVAC in Relapsed or Refractory T-lymphoblastic Lymphoma Unknown status NCT03558412 Phase 4 Decitabine
2 Hematology , Shanghai Jiaotong University Affiliated Shanghai First People's Hospital, Shanghai, China Unknown status NCT02938741 Phase 4 Anti-human Thymoglobulin;Placebo
3 An Open-label,Multi-center,Prospective Study of Idarubicin and Etoposide Intensified Conditioning Regimen Allogeneic Hematopoietic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
4 Determinants of Mercaptopurine Toxicity in Paediatric Acute Lymphoblastic Unknown status NCT03920813 Phase 4 Mercaptopurine
5 The Combination of Lower Dosage of Chemotherapy With Tyrosine Kinase Inhibitor to Treat Newly Diagnosed ph+ Acute Lymphoblastic Leukemia Patients Unknown status NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
6 Plasma Kinetics of Tablet and Liquid Formulations of 6-mercaptopurine in Childhood Acute Lymphoblastic Leukemia. Unknown status NCT01906671 Phase 4 Xaluprine;Puri-Nethol
7 Philadelphia -Negative High-risk Children Acute Lymphoblastic Leukemia(ALL) Treatment:Induction Therapy:Vincristine(V),Idarubicin(I),L-asparaginase(L),Dexamethasone(D);Consolidation:V+Daunorubicin(D)+L+D, Methotrexate,Cytarabine Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
8 Clinical Study of GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia in Guangdong Province Unknown status NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
9 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
10 PEG-asparaginase During Two Treatment Courses in the Treatment of Childhood Acute Lymphoblastic Leukemia Unknown status NCT00192673 Phase 4 PEG-asparaginase
11 Multicenter Study To Optimize Treatment in Elderly Patients (> 55 Years, No Upper Age Limit) With Acute Lymphoblastic Leukemia (GMALL Elderly 1/2003)(Amend 2) Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
12 Medical Research Council Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
13 Ma-Spore ALL 2010 Study Unknown status NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
14 G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor: a Prospective, Multicentre, Randomised Controlled Trial Unknown status NCT02933333 Phase 4
15 Multicenter Trial for Treatment Optimization in T-lymphoblastic Lymphoma in Adults and Adolescents Older Than 15 Years (GMALL T-LBL 1/2004) (Amend 1) Completed NCT00199017 Phase 4 Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
16 Multicenter Study to Optimise Therapy of B-ALL, Burkitt's NHL and High-Grade Non-Hodgkin's Lymphoma in Adults (Amend 7) Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
17 LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive Completed NCT00526305 Phase 4 Vincristine;Daunorubicin;Prednisone;L-Asparaginase;Mitoxantrone;Cytosine Arabinoside;Hydrocortisone;Mercaptopurine;Cyclophosphamide;Dexamethasone
18 Pulses of Vincristine and Dexamethasone During Maintenance in BFM Protocols for Children With Intermediate-Risk Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
19 LAL-BR/2001: Study Treatment to Low Risk ALL Completed NCT00526175 Phase 4 Prednisone;Vincristine;Daunorubicin;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside;Mercaptopurine;VP-16
20 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin;Mercaptopurine;Prednisone;Vincristine;Methotrexate
21 LAL-AR-N-2005: Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4 Prednisolone;Daunorubicin;Vincristine;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside
22 Treatment of High Risk Adult Acute Lymphoblastic Leukemia Completed NCT00853008 Phase 4 Vincristine;Daunorubicin;Prednisone;Mitoxantrone;Cytosine Arabinoside;Dexamethasone;Methotrexate (MTX);Cytarabine;ASP;Mercaptopurine;Teniposide;Hydrocortisone
23 The Study on the Pharmacokinetics of Pegylated Recombinant Human Granulocyte Stimulating Factor(PEG-rhG-CSF) in Children and Adolescents Completed NCT02953730 Phase 4 PEG-rhG-CSF
24 ALL-REZ BFM 2002: Protocol for the Treatment of Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
25 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 (Stoss Therapy) in Pediatric Patients Undergoing HSCT to Prevent Vitamin D Deficiency and Insufficiency During Transplant Completed NCT03176849 Phase 4
26 Vaccinating Children After Chemotherapy for Acute Lymphoblastic Leukemia: A Canadian Immunization Research Network Study Completed NCT02447718 Phase 4
27 German Multicenter Trial for Treatment Optimisation in Acute Lymphoblastic Leukemia in Adults and Adolescents Above 15 Years With Rituximab for Improvement of Prognosis in CD20 Positive Standard Risk ALL (Amend 2) Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
28 Pilot Study for Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
29 Multicenter Trial for Treatment of Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
30 German Multicenter Study for Treatment Optimisation in Acute Lymphoblastic Leukemia in Adults and Adolescents Above 15 Years (Amend 3) (GMALL 07/2003) Completed NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;Etoposide;Prednisolone;Adriamycin;Thioguanine;Teniposide;Idarubicin;Fludarabine;Cladribine
31 Multicenter Trial for Treatment of Acute Lymphocytic Leukemia in Adults (Pilot Study 06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
32 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4 Methylphenidate
33 A Randomized Open-Label Trial of Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Completed NCT01200355 Phase 4 micafungin;posaconazole
34 Prospective Study of Rituximab Combined With Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
35 Allogeneic Stem Cell Transplant for Children and Adolescents With Acute Lymoblastic Leukemia FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
36 Efficacy of the Use of Bortezomib for the Treatment of Relapsed Leukemia or Positive Minimal Residual Disease Recruiting NCT05137860 Phase 4 Bortezomib
37 Effect of Simvastatin on Sepsis and Febrile Neutropenia in Patients With Acute Lymphoblastic Leukemia Recruiting NCT05133310 Phase 4 Simvastatin
38 A Phase 4, Multi-center Open-label Feasibility Study to Evaluate Outpatient Blinatumomab Administration in Adult Subjects With Minimal Residual Disease (MRD) of B-precursor Acute Lymphoblastic Leukemia (ALL) in Complete Hematologic Remission Recruiting NCT04506086 Phase 4 Blinatumomab
39 PROTOCOL FOR THE TREATMENT Acute Lymphoblastic Leukemia With Ph 'NEGATIVE IN ELDERLY PATIENTS (> 55 Years) Recruiting NCT01366898 Phase 4 Dexamethasona, Idarubicine, ARA-C, Methotrexate
40 Shanghai General Hospital, Shanghai, Jiao Tong University School of Medicine Recruiting NCT05379569 Phase 4 Fludarabine
41 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
42 Treatment Protocol For All Fragile Patients Ph' Negative Over 55 Years Recruiting NCT01358201 Phase 4 vINCRISTINE;Dexamethasone;Methotrexate;Cytosine arabinoside
43 A PHASE 4, OPEN-LABEL, RANDOMIZED STUDY OF TWO INOTUZUMAB OZOGAMICIN DOSE LEVELS IN ADULT PATIENTS WITH RELAPSED OR REFRACTORY B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA ELIGIBLE FOR HEMATOPOIETIC STEM CELL TRANSPLANTATION AND WHO HAVE RISK FACTOR(S) FOR VENO-OCCLUSIVE DISEASE Active, not recruiting NCT03677596 Phase 4 inotuzumab ozogamicin-dose level 2;Inotuzumab ozogamicin-dose level 1
44 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Terminated NCT02618109 Phase 4
45 N-Acetylcysteine vs Placebo as Adjunctive Treatment in Pediatric Leukemia: A Single Blind, Randomized Controlled Trial Terminated NCT05611086 Phase 4 N-Acetylcysteine;Placebo
46 ProphyALL - Pilot Study on Safety of Four Weekly Administrations of 7 mg/kg of Liposomal Amphotericin B (AmBisome®) in Antifungal Primary Prophylaxis Treatment of Elderly Patients With Acute Lymphoblastic Leukemia Undergoing Induction Chemotherapy Within the GMALL-Elderly Protocol Terminated NCT00386997 Phase 4 liposomal amphotericin B (AmBisome®)
47 An Open-Label, One-Arm, Multi-Site Trial of Precision Diagnosis Directing Histone Deacetylase Inhibitor Chidamide Total Therapy for Adult T-lymphoblastic Lymphoma/Leukemia Unknown status NCT03564704 Phase 2, Phase 3 Dexamethasone;vincristine;Cyclophosphamide;Idarubicin;Pegaspargase;Adriamycin;Methotrexate;6-mercaptopurine.;Etoposide;Cytarabine;Chidamide
48 Pegylated Liposomal Doxorubicin-contained Versus Daunorubicin-contained VDCLD Regimen in Previously Untreated Adult Patients With Acute Lymphoblastic Leukemia: Complete Remission Rates and Changes of Leukemia Stem Cells Unknown status NCT02070523 Phase 3 VDCLD regimen
49 Phase III Study of Vincristine Sulfate Liposome Or Vincristine Sulfate For Injection Combined Chemotherapy as Initial Induction Regimen In Adults Acute Lymphoblastic Leukemia Unknown status NCT02072785 Phase 3 Vincristine Sulfate Liposome;Vincristine Sulfate
50 A Randomized Trial of the I-BFM-SG for the Management of Childhood Non-B Acute Lymphoblastic Leukemia Unknown status NCT00764907 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine

Search NIH Clinical Center for Lymphoblastic Lymphoma

Inferred drug relations via UMLS 71 / NDF-RT 50 :


ASPARAGINASE
Cyclophosphamide
Idarubicin
Idarubicin Hydrochloride
Ifosfamide
mercaptopurine
pegaspargase
sargramostim

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Lymphoblastic Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Lymphoblastic Lymphoma

Anatomical Context for Lymphoblastic Lymphoma

Organs/tissues related to Lymphoblastic Lymphoma:

FMA: Primarily Lymph Nodes, Extranodal Sites
MalaCards : T Cells, Bone Marrow, Myeloid, Bone, Nk Cells, Skin, Lymph Node

Publications for Lymphoblastic Lymphoma

Articles related to Lymphoblastic Lymphoma:

(show top 50) (show all 2266)
# Title Authors PMID Year
1
Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of t(14;18)-negative follicular lymphoma. 53 62
19633642 2009
2
Immunohistochemical evaluation of FLI-1 in acute lymphoblastic lymphoma (ALL): a potential diagnostic pitfall. 53 62
19349856 2009
3
PAX immunoreactivity identifies alveolar rhabdomyosarcoma. 53 62
19145202 2009
4
K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors. 53 62
18663146 2008
5
Reactivity with TdT in Merkel cell carcinoma: a potential diagnostic pitfall. 53 62
18480005 2008
6
A six-year-old boy with a suspicious thyroid nodule: intrathyroidal thymic tissue. 53 62
18341382 2008
7
TdT expression in Merkel cell carcinoma: potential diagnostic pitfall with blastic hematological malignancies and expanded immunohistochemical analysis. 53 62
17885674 2007
8
CD26, together with cell surface adenosine deaminase, is selectively expressed on ALK-positive, but not on ALK-negative, anaplastic large cell lymphoma and Hodgkin's lymphoma. 53 62
17071493 2006
9
Primary malignant lymphoma of the central nervous system in an immunocompetent child: a case report. 53 62
16217262 2005
10
Methylation status of cyclin-dependent kinase inhibitor genes within the transforming growth factor beta pathway in human T-cell lymphoblastic lymphoma/leukemia. 53 62
15475071 2004
11
[NSE-positive lymphoblastic lymphoma in a boy with cutaneous involvement, giant splenomegaly, and hyper-gamma globulinemia]. 53 62
15678916 2004
12
[Pathologic diagnoses of core needle biopsies of the mediastinum]. 53 62
15132850 2004
13
CD26 expression correlates with a reduced sensitivity to 2'-deoxycoformycin-induced growth inhibition and apoptosis in T-cell leukemia/lymphomas. 53 62
14760072 2004
14
Immunohistochemical expression of the transcription factor DP-1 and its heterodimeric partner E2F-1 in non-Hodgkin lymphoma. 53 62
12607600 2002
15
The 8p11 myeloproliferative syndrome: a distinct clinical entity caused by constitutive activation of FGFR1. 53 62
11919391 2002
16
Peripheral T-cell lymphoma with aberrant expression of CD79a and CD20: a diagnostic pitfall. 53 62
11235901 2001
17
Ewing sarcoma vs lymphoblastic lymphoma. A comparative immunohistochemical study. 53 62
11190795 2001
18
BCL-6 protein is expressed in precursor T-cell lymphoblastic lymphoma and in prenatal and postnatal thymus. 53 62
11133771 2001
19
Therapy-related T cell lymphoblastic lymphoma with t(11;19)(q23;p13) and MLL gene rearrangement. 53 62
10602439 1999
20
Lymphoblastic lymphoma expressing CD56 and TdT. 53 62
9422326 1998
21
MIC2, TdT, bcl-2, and CD34 expression in paraffin-embedded high-grade lymphoma/acute lymphoblastic leukemia distinguishes between distinct clinicopathologic entities. 53 62
9343323 1997
22
An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice. 53 62
9171354 1997
23
Terminal deoxynucleotidyl transferase staining of malignant lymphomas in paraffin sections: a useful method for the diagnosis of lymphoblastic lymphoma. 53 62
9227346 1997
24
Defects of the mismatch repair gene MSH2 are implicated in the development of murine and human lymphoblastic lymphomas and are associated with the aberrant expression of rhombotin-2 (Lmo-2) and Tal-1 (SCL). 53 62
9116269 1997
25
Lymphoblastic lymphoma expressing natural killer cell phenotype with involvement of the mediastinum and nasal cavity. 53 62
9042293 1997
26
Application of rearrangements of T cell receptor gene in the diagnosis of mediastinal T-lymphoblastic lymphoma: a case report. 53 62
9175304 1997
27
A T cell lymphoblastic lymphoma patient with two malignant cell populations carrying different 9p deletions including the p16INK4 and p15INK4B genes: Clinical response to interferon-alpha therapy in one of the subclones. 53 62
8656689 1996
28
Expression pattern of CD45 RA/RO isoformic antigens in T-lineage neoplasms. 53 62
7741140 1995
29
Involvement of CDKN2 (p16INK4A/MTS1) and p15INK4B/MTS2 in human leukemias and lymphomas. 53 62
7882348 1995
30
Terminal deoxynucleotidyl transferase staining of malignant lymphomas in paraffin sections. 53 62
7937725 1994
31
Lineage determination of CD7+ CD5- CD2- and CD7+ CD5+ CD2- lymphoblasts: studies on phenotype, genotype, and gene expression of myeloperoxidase, CD3 epsilon, and CD3 delta. 53 62
7513945 1994
32
Small cell osteosarcoma of bone: an immunohistochemical study with differential diagnostic considerations. 53 62
7503935 1993
33
Human recombination activating gene-1 in leukemia/lymphoma cells: expression depends on stage of lymphoid differentiation defined by phenotype and genotype. 53 62
8391873 1993
34
Emergence of a B-cell lymphoblastic lymphoma in a patient with B-cell chronic lymphocytic leukemia: evidence for the single-cell origin of the two tumors. 53 62
1859892 1991
35
Flow cytometric analysis of terminal deoxynucleotidyl transferase. 53 62
1996546 1991
36
Expression of enolases in T cell tumors and Hodgkin's disease. 53 62
2255187 1990
37
Genuine CD7 expression in acute leukemia and lymphoblastic lymphoma. 53 62
1701841 1990
38
Warthin tumor complicated with T-lymphoblastic lymphoma: a case report. 62
36416328 2022
39
Clinical and prognostic role of 2-[18F]FDG PET/CT and sarcopenia in treatment-naïve patients with T-cell lymphoblastic lymphoma. 62
36123452 2022
40
Prolonged COVID-19 infection in a child with lymphoblastic non-Hodgkin lymphoma: which is the best management? 62
34965799 2022
41
Recurrent microangiopathic hemolysis after recovery from complement-mediated hemolytic uremia syndrome during chemotherapy for a CFH-mutated patient with T-lymphoblastic lymphoma. 62
35790695 2022
42
MYC oncogene elicits tumorigenesis associated with embryonic, ribosomal biogenesis, and tissue-lineage dedifferentiation gene expression changes. 62
36207533 2022
43
Clinicopathological Spectrum of Cutaneous Lymphomas and Distinction of Early Mycosis Fungoides from its Mimics-A Retro-Prospective Descriptive Study from Southern India. 62
36386732 2022
44
Donor CD7 CAR-T bridging allogeneic hematopoietic stem cell transplantation for T-cell hematological malignancy. 62
36427783 2022
45
Diverse mutations and structural variations contribute to Notch signaling deregulation in paediatric T-cell lymphoblastic lymphoma. 62
36000950 2022
46
Primary cutaneous B-Cell lymphoblastic lymphoma presenting with solitary scalp mass in a female child: A case report and review of the literature. 62
36381035 2022
47
A phase 1 study to evaluate the safety, pharmacology, and feasibility of continuous infusion nelarabine in patients with relapsed and/or refractory lymphoid malignancies. 62
36448227 2022
48
Impact of poverty and neighborhood opportunity on outcomes for children treated with CD19-directed CAR T-cell therapy. 62
36351239 2022
49
Nelarabine, etoposide, and cyclophosphamide in relapsed pediatric T-acute lymphoblastic leukemia and T-lymphoblastic lymphoma (study T2008-002 NECTAR). 62
35989458 2022
50
Acute undifferentiated leukemia limited to neck lymph nodes and a large mediastinal mass. 62
36261335 2022

Variations for Lymphoblastic Lymphoma

Expression for Lymphoblastic Lymphoma

Search GEO for disease gene expression data for Lymphoblastic Lymphoma.

Pathways for Lymphoblastic Lymphoma

GO Terms for Lymphoblastic Lymphoma

Biological processes related to Lymphoblastic Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell activation GO:0042110 9.85 PTPRC CD8A CD7
2 regulation of cell population proliferation GO:0042127 9.8 TAL1 NOTCH1 CDKN1B BCL6
3 negative regulation of glial cell proliferation GO:0060253 9.73 NOTCH1 CDKN2B
4 B cell proliferation GO:0042100 9.73 BCL2 BCL6 PTPRC
5 positive regulation of B cell proliferation GO:0030890 9.63 PTPRC BCL6 BCL2
6 stem cell development GO:0048864 9.62 PTPRC BCL2
7 mesenchymal cell development GO:0014031 9.26 NOTCH1 BCL2
8 B cell differentiation GO:0030183 9.23 RAG1 PTPRC PAX5 BCL6 BCL2

Sources for Lymphoblastic Lymphoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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