Lymphoblastic Lymphoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LYM040 MIFTS: 53	Lymphoblastic Lymphoma Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Lymphoblastic Lymphoma

MalaCards integrated aliases for Lymphoblastic Lymphoma:

Name: Lymphoblastic Lymphoma ¹¹ ¹⁹ ⁷⁵ ¹⁴ ³⁶

Precursor Cell Lymphoblastic Leukemia Lymphoma ⁷¹

Precursor Cell Lymphoblastic Lymphoma ⁷¹

Lymphoma, Lymphoblastic ¹⁹

Lymphoma Lymphoblastic ⁵³

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Immune diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Neoplasms

Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue

Non-follicular lymphoma

Lymphoblastic (diffuse) lymphoma

External Ids:

Disease Ontology ¹¹ DOID:0080147

ICD10 ³¹ C83.5

UMLS ⁷¹ C0079748 C1961102

Sources

Summaries for Lymphoblastic Lymphoma

Disease Ontology: ¹¹ A lymphoma that has material basis in immature malignant lymphocytes (lymphoblasts) committed to the B-cell or T-cell lineage and located in primarily lymph nodes or located in extranodal sites.

MalaCards based summary: Lymphoblastic Lymphoma, also known as precursor cell lymphoblastic leukemia lymphoma, is related to b-lymphoblastic leukemia/lymphoma and childhood t-cell acute lymphoblastic leukemia. An important gene associated with Lymphoblastic Lymphoma is DNTT (DNA Nucleotidylexotransferase), and among its related pathways/superpathways are Hematopoietic Stem Cells and Lineage-specific Markers and NF-kappaB Signaling. The drugs Lenograstim and Morphine have been mentioned in the context of this disorder. Affiliated tissues include primarily lymph nodes, extranodal sites and t cells, and related phenotypes are nervous system and growth/size/body region

GARD: ¹⁹ A lymphoma composed of immature small to medium-sized precursor lymphoid cells (lymphoblasts). It includes the B- and T-cell lymphoblastic lymphoma.

Wikipedia: ⁷⁵ Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the... more...

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Related Diseases for Lymphoblastic Lymphoma

Diseases related to Lymphoblastic Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 404)

#	Related Disease	Score	Top Affiliating Genes
1	b-lymphoblastic leukemia/lymphoma	32.1	PTPRC PAX5 DNTT CDKN2B CD7
2	childhood t-cell acute lymphoblastic leukemia	31.9	TAL1 LMO2 CD7
3	t-cell acute lymphoblastic leukemia	31.3	TNFRSF8 TAL1 RAG1 PTPRC NOTCH1 LMO2
4	burkitt lymphoma	31.3	TNFRSF8 PAX5 DNTT CDKN2B BCL6 BCL2
5	precursor t-cell acute lymphoblastic leukemia	30.9	TAL1 NOTCH1 LMO2 DNTT CDKN2B CD7
6	leukemia, acute lymphoblastic	30.8	TAL1 RAG1 PTPRC PAX5 NOTCH1 LMO2
7	lymphoma	30.8	ZMYM2 TNFRSF8 TAL1 PTPRC PAX5 FGFR1
8	lymphoma, hodgkin, classic	30.8	TNFRSF8 RAG1 PTPRC PAX5 BCL6 BCL2
9	leukemia	30.7	ZMYM2 TAL1 NOTCH1 LMO2 FLI1 FGFR1
10	thymoma	30.7	PTPRC DNTT CD8A BCL2
11	ovarian lymphoma	30.6	DNTT BCL6 BCL2
12	myeloid sarcoma	30.4	TNFRSF8 PTPRC DNTT CD7
13	mediastinal cancer	30.4	TNFRSF8 PAX5
14	lymphosarcoma	30.4	TNFRSF8 BCL6 BCL2
15	diffuse large b-cell lymphoma	30.4	TNFRSF8 PAX5 BCL6 BCL2
16	ewing sarcoma	30.4	TNFRSF8 PTPRC FLI1 FGFR1 DNTT CD99
17	acute biphenotypic leukemia	30.3	PAX5 DNTT CD7
18	thymus cancer	30.3	PTPRC DNTT CD8A BCL2
19	testicular lymphoma	30.2	TNFRSF8 BCL6 BCL2
20	acute leukemia	30.2	TAL1 PAX5 DNTT CDKN2B CD8A CD7
21	b-cell lymphoma	30.2	TNFRSF8 PTPRC PAX5 CDKN2B CDKN1B BCL6
22	lymphoproliferative syndrome	30.2	TNFRSF8 BCL6 BCL2
23	breast lymphoma	30.2	TNFRSF8 PAX5 BCL6 BCL2
24	leukemia, chronic myeloid	30.1	TAL1 PTPRC NOTCH1 FGFR1 DNTT CDKN2B
25	hematologic cancer	30.1	TNFRSF8 PAX5 NOTCH1 FGFR1 DNTT CDKN2B
26	adult t-cell leukemia/lymphoma	30.1	TNFRSF8 CD8A CD7 BCL2
27	mycosis fungoides	30.0	TNFRSF8 CDKN2B CD7 BCL2
28	t-cell adult acute lymphocytic leukemia	30.0	TNFRSF8 CD8A CD7
29	anaplastic large cell lymphoma	30.0	TNFRSF8 PTPRC PAX5 CDKN1B BCL2
30	myelodysplastic syndrome	30.0	PTPRC FGFR1 DNTT CDKN2B CD8A CD7
31	childhood lymphoma	30.0	TNFRSF8 PAX5 DNTT BCL6 BCL2
32	breast implant-associated anaplastic large cell lymphoma	30.0	TNFRSF8 CD7
33	lymphatic system disease	29.9	TNFRSF8 CD8A BCL6 BCL2
34	marginal zone b-cell lymphoma	29.9	TNFRSF8 PAX5 BCL6 BCL2
35	lymphoplasmacytic lymphoma	29.9	PAX5 BCL6 BCL2
36	mediastinal malignant lymphoma	29.9	TNFRSF8 PAX5
37	primary cutaneous t-cell non-hodgkin lymphoma	29.9	TNFRSF8 CDKN2B CD7
38	peripheral t-cell lymphoma	29.8	TNFRSF8 PTPRC PAX5 CD8A CD7 BCL6
39	mantle cell lymphoma	29.8	TNFRSF8 PTPRC PAX5 NOTCH1 CD8A BCL6
40	angioimmunoblastic t-cell lymphoma	29.8	TNFRSF8 PAX5 CD8A CD7 BCL6
41	peripheral nervous system disease	29.8	TNFRSF8 PTPRC NOTCH1 CD8A BCL2
42	wilms tumor 1	29.7	PTPRC NOTCH1 CD99 CD8A BCL2
43	composite lymphoma	29.7	TNFRSF8 PAX5 BCL6 BCL2
44	chronic lymphocytic leukemia/small lymphocytic lymphoma	29.7	TNFRSF8 PAX5 BCL6 BCL2
45	central nervous system lymphoma	29.7	TNFRSF8 PAX5 BCL6 BCL2
46	adult acute lymphocytic leukemia	29.6	TNFRSF8 TAL1 PAX5 CDKN2B CD8A CD7
47	nervous system disease	29.6	PTPRC NOTCH1 FGFR1 DNTT CDKN2B CDKN1B
48	acute promyelocytic leukemia	29.4	PTPRC NOTCH1 DNTT CDKN2B CDKN1B CD7
49	skin disease	29.4	TNFRSF8 PTPRC NOTCH1 CD8A CD7 BCL2
50	lymphoma, non-hodgkin, familial	29.4	ZMYM2 TNFRSF8 TAL1 RAG1 PTPRC PAX5

Graphical network of the top 20 diseases related to Lymphoblastic Lymphoma:

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Symptoms & Phenotypes for Lymphoblastic Lymphoma

GenomeRNAi Phenotypes related to Lymphoblastic Lymphoma according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.19	BCL2 BCL6 CD7 CD8A CDKN1B CDKN2B
2	no effect	GR00402-S-2	10.19	BCL2 BCL6 CD7 CD99 CDKN1B CDKN2B

MGI Mouse Phenotypes related to Lymphoblastic Lymphoma:

⁴⁵ (show all 13)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	10.27	BCL2 CD8A CDKN1B CEP85L FGFR1 FLI1
2	growth/size/body region	MP:0005378	10.25	BCL2 BCL6 CDKN1B CEP85L FGFR1 FGFR1OP2
3	renal/urinary system	MP:0005367	10.22	BCL2 CD8A CDKN1B CDKN2B CEP85L FGFR1
4	immune system	MP:0005387	10.21	BCL2 BCL6 CD7 CD8A CD99 CDKN1B
5	endocrine/exocrine gland	MP:0005379	10.18	BCL2 BCL6 CD7 CD8A CDKN1B CDKN2B
6	cellular	MP:0005384	10.18	BCL2 BCL6 CD8A CDKN1B CDKN2B FGFR1
7	neoplasm	MP:0002006	10.16	BCL2 CDKN1B CDKN2B FLI1 LMO2 NOTCH1
8	hematopoietic system	MP:0005397	10.09	BCL2 BCL6 CD7 CD8A CD99 CDKN1B
9	cardiovascular system	MP:0005385	10.06	BCL2 BCL6 CDKN1B FGFR1 FGFR1OP2 FLI1
10	hearing/vestibular/ear	MP:0005377	10	BCL2 CDKN1B CEP85L FGFR1 NOTCH1 PAX5
11	pigmentation	MP:0001186	9.92	BCL2 CDKN1B NOTCH1 RAG1 TAL1
12	mortality/aging	MP:0010768	9.83	BCL2 BCL6 CD8A CDKN1B CDKN2B FGFR1
13	integument	MP:0010771	9.44	BCL2 BCL6 CD8A CDKN1B CDKN2B CEP85L

Sources

Drugs & Therapeutics for Lymphoblastic Lymphoma

Drugs for Lymphoblastic Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 523)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Lenograstim

Approved, Investigational

Phase 4

135968-09-1

Morphine

Approved, Investigational

Phase 4

57-27-2

5288826

Sargramostim

Approved, Investigational

Phase 4

123774-72-1

Nicotine

Approved

Phase 4

54-11-5

942 89594

Cladribine

Approved, Investigational

Phase 4

4291-63-8

20279

Teniposide

Approved

Phase 4

29767-20-2

34698 452548

Dopamine

Approved

Phase 4

62-31-7, 51-61-6

681

Methylphenidate

Approved, Investigational

Phase 4

113-45-1

4158

Posaconazole

Approved, Investigational, Vet_approved

Phase 4

171228-49-2

147912

Micafungin

Approved, Investigational

Phase 4

235114-32-6

477468

Idarubicin

Approved

Phase 4

58957-92-9

42890

Treosulfan

Approved, Investigational

Phase 4

299-75-2

9296

Simvastatin

Approved

Phase 4

79902-63-9

54454

Acetylcysteine

Approved, Investigational

Phase 4

616-91-1

581 12035

Cholecalciferol

Approved, Nutraceutical, Vet_approved

Phase 4

67-97-0, 1406-16-2

5280795 10883523

Calcifediol

Approved, Nutraceutical

Phase 4

19356-17-3

5283731

Ergocalciferol

Approved, Nutraceutical

Phase 4

50-14-6

5280793

Molgramostim

Investigational

Phase 4

99283-10-0

Adjuvants, Immunologic

Phase 4

Ethylene

Phase 4

74-85-1

6325

Neurotransmitter Agents

Phase 4

Calciferol

Phase 4

Central Nervous System Stimulants

Phase 4

Dopamine Uptake Inhibitors

Phase 4

Dopamine Agents

Phase 4

Heptavalent Pneumococcal Conjugate Vaccine

Phase 4

Antiprotozoal Agents

Phase 4

Antiparasitic Agents

Phase 4

Cytochrome P-450 Enzyme Inhibitors

Phase 4

Vitamin D2

Phase 4

3249

Ergocalciferols

Phase 4

Hydroxycholecalciferols

Phase 4

Hypolipidemic Agents

Phase 4

Anticholesteremic Agents

Phase 4

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Phase 4

Lipid Regulating Agents

Phase 4

Respiratory System Agents

Phase 4

Antioxidants

Phase 4

Expectorants

Phase 4

N-monoacetylcystine

Phase 4

Lorazepam

Approved

Phase 3

846-49-1

3958

Pentoxifylline

Approved, Investigational

Phase 2, Phase 3

6493-05-6

4740

Sirolimus

Approved, Investigational

Phase 3

53123-88-9

5284616 6436030

Methotrexate

Approved

Phase 3

1959-05-2, 59-05-2

4112 126941

Risedronic acid

Approved, Investigational

Phase 3

105462-24-6

5245

Etidronic acid

Approved

Phase 3

2809-21-4, 7414-83-7

3305

Epirubicin

Approved

Phase 3

56420-45-2

41867

Carvedilol

Approved, Investigational

Phase 3

72956-09-3

2585

Enalaprilat

Approved

Phase 3

76420-72-9

6917719 5462501

Enalapril

Approved, Vet_approved

Phase 3

75847-73-3

40466924 5388962 5362032

Interventional clinical trials:

(show top 50) (show all 1714)

#	Name	Status	NCT ID	Phase	Drugs
1	A Clinical Trial of Decitabine Combined With CODOX-M/IVAC in Relapsed or Refractory T-lymphoblastic Lymphoma	Unknown status	NCT03558412	Phase 4	Decitabine
2	Hematology , Shanghai Jiaotong University Affiliated Shanghai First People's Hospital, Shanghai, China	Unknown status	NCT02938741	Phase 4	Anti-human Thymoglobulin;Placebo
3	An Open-label,Multi-center,Prospective Study of Idarubicin and Etoposide Intensified Conditioning Regimen Allogeneic Hematopoietic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia	Unknown status	NCT01873807	Phase 4	IDA;CTX;VP-16
4	Determinants of Mercaptopurine Toxicity in Paediatric Acute Lymphoblastic	Unknown status	NCT03920813	Phase 4	Mercaptopurine
5	The Combination of Lower Dosage of Chemotherapy With Tyrosine Kinase Inhibitor to Treat Newly Diagnosed ph+ Acute Lymphoblastic Leukemia Patients	Unknown status	NCT02690922	Phase 4	Dasatinib;prednisone;dexamethasone;methotrexate
6	Plasma Kinetics of Tablet and Liquid Formulations of 6-mercaptopurine in Childhood Acute Lymphoblastic Leukemia.	Unknown status	NCT01906671	Phase 4	Xaluprine;Puri-Nethol
7	Philadelphia -Negative High-risk Children Acute Lymphoblastic Leukemia(ALL) Treatment:Induction Therapy:Vincristine(V),Idarubicin(I),L-asparaginase(L),Dexamethasone(D);Consolidation:V+Daunorubicin(D)+L+D, Methotrexate,Cytarabine	Unknown status	NCT01990807	Phase 4	Idarubicin(IDA)
8	Clinical Study of GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia in Guangdong Province	Unknown status	NCT00846703	Phase 4	6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
9	Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults	Unknown status	NCT00797810	Phase 4	Rituximab
10	PEG-asparaginase During Two Treatment Courses in the Treatment of Childhood Acute Lymphoblastic Leukemia	Unknown status	NCT00192673	Phase 4	PEG-asparaginase
11	Multicenter Study To Optimize Treatment in Elderly Patients (> 55 Years, No Upper Age Limit) With Acute Lymphoblastic Leukemia (GMALL Elderly 1/2003)(Amend 2)	Unknown status	NCT00198978	Phase 4	Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
12	Medical Research Council Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003	Unknown status	NCT00222612	Phase 4	Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
13	Ma-Spore ALL 2010 Study	Unknown status	NCT02894645	Phase 4	Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
14	G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor: a Prospective, Multicentre, Randomised Controlled Trial	Unknown status	NCT02933333	Phase 4
15	Multicenter Trial for Treatment Optimization in T-lymphoblastic Lymphoma in Adults and Adolescents Older Than 15 Years (GMALL T-LBL 1/2004) (Amend 1)	Completed	NCT00199017	Phase 4	Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
16	Multicenter Study to Optimise Therapy of B-ALL, Burkitt's NHL and High-Grade Non-Hodgkin's Lymphoma in Adults (Amend 7)	Completed	NCT00199082	Phase 4	Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
17	LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive	Completed	NCT00526305	Phase 4	Vincristine;Daunorubicin;Prednisone;L-Asparaginase;Mitoxantrone;Cytosine Arabinoside;Hydrocortisone;Mercaptopurine;Cyclophosphamide;Dexamethasone
18	Pulses of Vincristine and Dexamethasone During Maintenance in BFM Protocols for Children With Intermediate-Risk Acute Lymphoblastic Leukemia	Completed	NCT00411541	Phase 4	vincristine;dexamethasone
19	LAL-BR/2001: Study Treatment to Low Risk ALL	Completed	NCT00526175	Phase 4	Prednisone;Vincristine;Daunorubicin;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside;Mercaptopurine;VP-16
20	PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia	Completed	NCT00494897	Phase 4	Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin;Mercaptopurine;Prednisone;Vincristine;Methotrexate
21	LAL-AR-N-2005: Study Treatment for Children High Risk Acute Lymphoblastic Leukemia	Completed	NCT00526409	Phase 4	Prednisolone;Daunorubicin;Vincristine;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside
22	Treatment of High Risk Adult Acute Lymphoblastic Leukemia	Completed	NCT00853008	Phase 4	Vincristine;Daunorubicin;Prednisone;Mitoxantrone;Cytosine Arabinoside;Dexamethasone;Methotrexate (MTX);Cytarabine;ASP;Mercaptopurine;Teniposide;Hydrocortisone
23	The Study on the Pharmacokinetics of Pegylated Recombinant Human Granulocyte Stimulating Factor（PEG-rhG-CSF） in Children and Adolescents	Completed	NCT02953730	Phase 4	PEG-rhG-CSF
24	ALL-REZ BFM 2002: Protocol for the Treatment of Children With Relapsed Acute Lymphoblastic Leukemia	Completed	NCT00114348	Phase 4
25	A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 (Stoss Therapy) in Pediatric Patients Undergoing HSCT to Prevent Vitamin D Deficiency and Insufficiency During Transplant	Completed	NCT03176849	Phase 4
26	Vaccinating Children After Chemotherapy for Acute Lymphoblastic Leukemia: A Canadian Immunization Research Network Study	Completed	NCT02447718	Phase 4
27	German Multicenter Trial for Treatment Optimisation in Acute Lymphoblastic Leukemia in Adults and Adolescents Above 15 Years With Rituximab for Improvement of Prognosis in CD20 Positive Standard Risk ALL (Amend 2)	Completed	NCT00199004	Phase 4	Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
28	Pilot Study for Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia	Completed	NCT00199095	Phase 4	Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
29	Multicenter Trial for Treatment of Acute Lymphoblastic Leukemia in Adults (05/93)	Completed	NCT00199069	Phase 4	Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
30	German Multicenter Study for Treatment Optimisation in Acute Lymphoblastic Leukemia in Adults and Adolescents Above 15 Years (Amend 3) (GMALL 07/2003)	Completed	NCT00198991	Phase 4	Cyclophosphamide;Dexamethasone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;Etoposide;Prednisolone;Adriamycin;Thioguanine;Teniposide;Idarubicin;Fludarabine;Cladribine
31	Multicenter Trial for Treatment of Acute Lymphocytic Leukemia in Adults (Pilot Study 06/99)	Completed	NCT00199056	Phase 4	Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
32	Learning Impairments Among Survivors of Childhood Cancer	Completed	NCT00576472	Phase 4	Methylphenidate
33	A Randomized Open-Label Trial of Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome	Completed	NCT01200355	Phase 4	micafungin;posaconazole
34	Prospective Study of Rituximab Combined With Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia	Completed	NCT01358253	Phase 4	Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
35	Allogeneic Stem Cell Transplant for Children and Adolescents With Acute Lymoblastic Leukemia FORUM - Pharmacogenomic Study (add-on Study)	Recruiting	NCT02670564	Phase 4
36	Efficacy of the Use of Bortezomib for the Treatment of Relapsed Leukemia or Positive Minimal Residual Disease	Recruiting	NCT05137860	Phase 4	Bortezomib
37	Effect of Simvastatin on Sepsis and Febrile Neutropenia in Patients With Acute Lymphoblastic Leukemia	Recruiting	NCT05133310	Phase 4	Simvastatin
38	A Phase 4, Multi-center Open-label Feasibility Study to Evaluate Outpatient Blinatumomab Administration in Adult Subjects With Minimal Residual Disease (MRD) of B-precursor Acute Lymphoblastic Leukemia (ALL) in Complete Hematologic Remission	Recruiting	NCT04506086	Phase 4	Blinatumomab
39	PROTOCOL FOR THE TREATMENT Acute Lymphoblastic Leukemia With Ph 'NEGATIVE IN ELDERLY PATIENTS (> 55 Years)	Recruiting	NCT01366898	Phase 4	Dexamethasona, Idarubicine, ARA-C, Methotrexate
40	Shanghai General Hospital, Shanghai, Jiao Tong University School of Medicine	Recruiting	NCT05379569	Phase 4	Fludarabine
41	Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE	Recruiting	NCT01491763	Phase 4	Imatinib
42	Treatment Protocol For All Fragile Patients Ph' Negative Over 55 Years	Recruiting	NCT01358201	Phase 4	vINCRISTINE;Dexamethasone;Methotrexate;Cytosine arabinoside
43	A PHASE 4, OPEN-LABEL, RANDOMIZED STUDY OF TWO INOTUZUMAB OZOGAMICIN DOSE LEVELS IN ADULT PATIENTS WITH RELAPSED OR REFRACTORY B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA ELIGIBLE FOR HEMATOPOIETIC STEM CELL TRANSPLANTATION AND WHO HAVE RISK FACTOR(S) FOR VENO-OCCLUSIVE DISEASE	Active, not recruiting	NCT03677596	Phase 4	inotuzumab ozogamicin-dose level 2;Inotuzumab ozogamicin-dose level 1
44	Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia	Terminated	NCT02618109	Phase 4
45	N-Acetylcysteine vs Placebo as Adjunctive Treatment in Pediatric Leukemia: A Single Blind, Randomized Controlled Trial	Terminated	NCT05611086	Phase 4	N-Acetylcysteine;Placebo
46	ProphyALL - Pilot Study on Safety of Four Weekly Administrations of 7 mg/kg of Liposomal Amphotericin B (AmBisome®) in Antifungal Primary Prophylaxis Treatment of Elderly Patients With Acute Lymphoblastic Leukemia Undergoing Induction Chemotherapy Within the GMALL-Elderly Protocol	Terminated	NCT00386997	Phase 4	liposomal amphotericin B (AmBisome®)
47	An Open-Label, One-Arm, Multi-Site Trial of Precision Diagnosis Directing Histone Deacetylase Inhibitor Chidamide Total Therapy for Adult T-lymphoblastic Lymphoma/Leukemia	Unknown status	NCT03564704	Phase 2, Phase 3	Dexamethasone;vincristine;Cyclophosphamide;Idarubicin;Pegaspargase;Adriamycin;Methotrexate;6-mercaptopurine.;Etoposide;Cytarabine;Chidamide
48	Pegylated Liposomal Doxorubicin-contained Versus Daunorubicin-contained VDCLD Regimen in Previously Untreated Adult Patients With Acute Lymphoblastic Leukemia: Complete Remission Rates and Changes of Leukemia Stem Cells	Unknown status	NCT02070523	Phase 3	VDCLD regimen
49	Phase III Study of Vincristine Sulfate Liposome Or Vincristine Sulfate For Injection Combined Chemotherapy as Initial Induction Regimen In Adults Acute Lymphoblastic Leukemia	Unknown status	NCT02072785	Phase 3	Vincristine Sulfate Liposome;Vincristine Sulfate
50	A Randomized Trial of the I-BFM-SG for the Management of Childhood Non-B Acute Lymphoblastic Leukemia	Unknown status	NCT00764907	Phase 3	asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine

Search NIH Clinical Center for Lymphoblastic Lymphoma

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

ASPARAGINASE

Cyclophosphamide

Idarubicin

Idarubicin Hydrochloride

Ifosfamide

mercaptopurine

pegaspargase

sargramostim

Cell-based therapeutics:

Data from LifeMap, the Embryonic Development and Stem Cells Database

Read about Lymphoblastic Lymphoma cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Lymphoblastic Lymphoma:

	Blood stem cell transplantation for hematological diseases
	Hematopoietic stem cells for treatment of hematologic malignancies
	Peripheral blood stem cells for treatment of hematologic malignancies

Embryonic/Adult Cultured Cells Related to Lymphoblastic Lymphoma:

	Peripheral blood-derived hematopoietic stem cells (family)
	Bone marrow-derived hematopoietic stem cells

Sources

Genetic Tests for Lymphoblastic Lymphoma

Sources

Anatomical Context for Lymphoblastic Lymphoma

Organs/tissues related to Lymphoblastic Lymphoma:

FMA: Primarily Lymph Nodes, Extranodal Sites

MalaCards : T Cells, Bone Marrow, Myeloid, Bone, Nk Cells, Skin, Lymph Node

Sources

Publications for Lymphoblastic Lymphoma

Articles related to Lymphoblastic Lymphoma:

(show top 50) (show all 2266)

#	Title	Authors	PMID	Year
1	Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of t(14;18)-negative follicular lymphoma. ⁵³ ⁶²	Chiu A...Orazi A	19633642	2009
2	Immunohistochemical evaluation of FLI-1 in acute lymphoblastic lymphoma (ALL): a potential diagnostic pitfall. ⁵³ ⁶²	Lin O...Teruya-Feldstein J	19349856	2009
3	PAX immunoreactivity identifies alveolar rhabdomyosarcoma. ⁵³ ⁶²	Sullivan LM...LeGallo RD	19145202	2009
4	K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors. ⁵³ ⁶²	Kindler T...Gilliland DG	18663146	2008
5	Reactivity with TdT in Merkel cell carcinoma: a potential diagnostic pitfall. ⁵³ ⁶²	Buresh CJ...Miller RT	18480005	2008
6	A six-year-old boy with a suspicious thyroid nodule: intrathyroidal thymic tissue. ⁵³ ⁶²	Hernandez-Cassis C...McKenzie JM	18341382	2008
7	TdT expression in Merkel cell carcinoma: potential diagnostic pitfall with blastic hematological malignancies and expanded immunohistochemical analysis. ⁵³ ⁶²	Sur M...Alowami S	17885674	2007
8	CD26, together with cell surface adenosine deaminase, is selectively expressed on ALK-positive, but not on ALK-negative, anaplastic large cell lymphoma and Hodgkin's lymphoma. ⁵³ ⁶²	Kameoka J...Sasaki T	17071493	2006
9	Primary malignant lymphoma of the central nervous system in an immunocompetent child: a case report. ⁵³ ⁶²	Shiozawa Y...Yamashiro Y	16217262	2005
10	Methylation status of cyclin-dependent kinase inhibitor genes within the transforming growth factor beta pathway in human T-cell lymphoblastic lymphoma/leukemia. ⁵³ ⁶²	Scott SA...DeCoteau JF	15475071	2004
11	[NSE-positive lymphoblastic lymphoma in a boy with cutaneous involvement, giant splenomegaly, and hyper-gamma globulinemia]. ⁵³ ⁶²	Takahashi K...Nakazawa S	15678916	2004
12	[Pathologic diagnoses of core needle biopsies of the mediastinum]. ⁵³ ⁶²	Liu M...Li XH	15132850	2004
13	CD26 expression correlates with a reduced sensitivity to 2'-deoxycoformycin-induced growth inhibition and apoptosis in T-cell leukemia/lymphomas. ⁵³ ⁶²	Aldinucci D...Gattei V	14760072	2004
14	Immunohistochemical expression of the transcription factor DP-1 and its heterodimeric partner E2F-1 in non-Hodgkin lymphoma. ⁵³ ⁶²	Chan JA...Brynes RK	12607600	2002
15	The 8p11 myeloproliferative syndrome: a distinct clinical entity caused by constitutive activation of FGFR1. ⁵³ ⁶²	Macdonald D...Cross NC	11919391	2002
16	Peripheral T-cell lymphoma with aberrant expression of CD79a and CD20: a diagnostic pitfall. ⁵³ ⁶²	Yao X...Jaffe ES	11235901	2001
17	Ewing sarcoma vs lymphoblastic lymphoma. A comparative immunohistochemical study. ⁵³ ⁶²	Lucas DR...Mott MP	11190795	2001
18	BCL-6 protein is expressed in precursor T-cell lymphoblastic lymphoma and in prenatal and postnatal thymus. ⁵³ ⁶²	Hyjek E...Knowles DM	11133771	2001
19	Therapy-related T cell lymphoblastic lymphoma with t(11;19)(q23;p13) and MLL gene rearrangement. ⁵³ ⁶²	Thandla S...Aplan PD	10602439	1999
20	Lymphoblastic lymphoma expressing CD56 and TdT. ⁵³ ⁶²	Nakamura S...Suchi T	9422326	1998
21	MIC2, TdT, bcl-2, and CD34 expression in paraffin-embedded high-grade lymphoma/acute lymphoblastic leukemia distinguishes between distinct clinicopathologic entities. ⁵³ ⁶²	Soslow RA...Warnke RA	9343323	1997
22	An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice. ⁵³ ⁶²	Aplan PD...Gross KW	9171354	1997
23	Terminal deoxynucleotidyl transferase staining of malignant lymphomas in paraffin sections: a useful method for the diagnosis of lymphoblastic lymphoma. ⁵³ ⁶²	Suzumiya J...Tashiro K	9227346	1997
24	Defects of the mismatch repair gene MSH2 are implicated in the development of murine and human lymphoblastic lymphomas and are associated with the aberrant expression of rhombotin-2 (Lmo-2) and Tal-1 (SCL). ⁵³ ⁶²	Lowsky R...Minden MD	9116269	1997
25	Lymphoblastic lymphoma expressing natural killer cell phenotype with involvement of the mediastinum and nasal cavity. ⁵³ ⁶²	Koita H...Koono M	9042293	1997
26	Application of rearrangements of T cell receptor gene in the diagnosis of mediastinal T-lymphoblastic lymphoma: a case report. ⁵³ ⁶²	Change KE...Chen PM	9175304	1997
27	A T cell lymphoblastic lymphoma patient with two malignant cell populations carrying different 9p deletions including the p16INK4 and p15INK4B genes: Clinical response to interferon-alpha therapy in one of the subclones. ⁵³ ⁶²	Heyman M...Johansson B	8656689	1996
28	Expression pattern of CD45 RA/RO isoformic antigens in T-lineage neoplasms. ⁵³ ⁶²	Kawano S...Nakamura F	7741140	1995
29	Involvement of CDKN2 (p16INK4A/MTS1) and p15INK4B/MTS2 in human leukemias and lymphomas. ⁵³ ⁶²	Otsuki T...Raffeld M	7882348	1995
30	Terminal deoxynucleotidyl transferase staining of malignant lymphomas in paraffin sections. ⁵³ ⁶²	Orazi A...Neiman RS	7937725	1994
31	Lineage determination of CD7+ CD5- CD2- and CD7+ CD5+ CD2- lymphoblasts: studies on phenotype, genotype, and gene expression of myeloperoxidase, CD3 epsilon, and CD3 delta. ⁵³ ⁶²	Yoneda N...Yamaguchi N	7513945	1994
32	Small cell osteosarcoma of bone: an immunohistochemical study with differential diagnostic considerations. ⁵³ ⁶²	Devaney K...Sweet DE	7503935	1993
33	Human recombination activating gene-1 in leukemia/lymphoma cells: expression depends on stage of lymphoid differentiation defined by phenotype and genotype. ⁵³ ⁶²	Yoneda N...Yamaguchi N	8391873	1993
34	Emergence of a B-cell lymphoblastic lymphoma in a patient with B-cell chronic lymphocytic leukemia: evidence for the single-cell origin of the two tumors. ⁵³ ⁶²	Pistoia V...Ferrarini M	1859892	1991
35	Flow cytometric analysis of terminal deoxynucleotidyl transferase. ⁵³ ⁶²	Almasri NM...Braylan RC	1996546	1991
36	Expression of enolases in T cell tumors and Hodgkin's disease. ⁵³ ⁶²	Oka K...Kato K	2255187	1990
37	Genuine CD7 expression in acute leukemia and lymphoblastic lymphoma. ⁵³ ⁶²	Osada H...Takahashi T	1701841	1990
38	Warthin tumor complicated with T-lymphoblastic lymphoma: a case report. ⁶²	Xi Y...Zhao M	36416328	2022
39	Clinical and prognostic role of 2-[18F]FDG PET/CT and sarcopenia in treatment-naïve patients with T-cell lymphoblastic lymphoma. ⁶²	Tan X...Jiang L	36123452	2022
40	Prolonged COVID-19 infection in a child with lymphoblastic non-Hodgkin lymphoma: which is the best management? ⁶²	Gattuso G...Massimino M	34965799	2022
41	Recurrent microangiopathic hemolysis after recovery from complement-mediated hemolytic uremia syndrome during chemotherapy for a CFH-mutated patient with T-lymphoblastic lymphoma. ⁶²	Lee FW...Yen HJ	35790695	2022
42	MYC oncogene elicits tumorigenesis associated with embryonic, ribosomal biogenesis, and tissue-lineage dedifferentiation gene expression changes. ⁶²	Sullivan DK...Felsher DW	36207533	2022
43	Clinicopathological Spectrum of Cutaneous Lymphomas and Distinction of Early Mycosis Fungoides from its Mimics-A Retro-Prospective Descriptive Study from Southern India. ⁶²	Durgadevi S...Kar R	36386732	2022
44	Donor CD7 CAR-T bridging allogeneic hematopoietic stem cell transplantation for T-cell hematological malignancy. ⁶²	Li Z...Wu T	36427783	2022
45	Diverse mutations and structural variations contribute to Notch signaling deregulation in paediatric T-cell lymphoblastic lymphoma. ⁶²	Salmeron-Villalobos J...Salaverria I	36000950	2022
46	Primary cutaneous B-Cell lymphoblastic lymphoma presenting with solitary scalp mass in a female child: A case report and review of the literature. ⁶²	Montazer F...Dastgir R	36381035	2022
47	A phase 1 study to evaluate the safety, pharmacology, and feasibility of continuous infusion nelarabine in patients with relapsed and/or refractory lymphoid malignancies. ⁶²	Boddu PC...Kadia TM	36448227	2022
48	Impact of poverty and neighborhood opportunity on outcomes for children treated with CD19-directed CAR T-cell therapy. ⁶²	Newman H...Barz Leahy A	36351239	2022
49	Nelarabine, etoposide, and cyclophosphamide in relapsed pediatric T-acute lymphoblastic leukemia and T-lymphoblastic lymphoma (study T2008-002 NECTAR). ⁶²	Whitlock JA...Gore L	35989458	2022
50	Acute undifferentiated leukemia limited to neck lymph nodes and a large mediastinal mass. ⁶²	Hayashino K...Imai T	36261335	2022

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Genes for Lymphoblastic Lymphoma

Genes related to Lymphoblastic Lymphoma (0 elite genes):

(show all 31)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	DNTT	DNA Nucleotidylexotransferase	Protein Coding	26.07	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11190795 18480005 7937725 (more) 9042293 9175304 16217262 9353824 19633642 18341382 17885674 9343323 9227346 9422326 1996546 1859892 9110287
2	CD99	CD99 Molecule (Xg Blood Group)	Protein Coding	22.05	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8163272 9343323
3	ZMYM2	Zinc Finger MYM-Type Containing 2	Protein Coding	21.76	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
4	CD7	CD7 Molecule	Protein Coding	21.22	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1701841 7741140
5	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	21.07	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11190795 7503935
6	BCL6	BCL6 Transcription Repressor	Protein Coding	19.73	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11133771 9310496
7	NOTCH1	Notch Receptor 1	Protein Coding	19.2	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18663146
8	FLI1	Fli-1 Proto-Oncogene, ETS Transcription Factor	Protein Coding	18.8	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	19349856 11117787
9	TAL1	TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor	Protein Coding	18.51	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9116269 9171354
10	LMO2	LIM Domain Only 2	Protein Coding	18.48	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9116269
11	CDKN2B	Cyclin Dependent Kinase Inhibitor 2B	Protein Coding	17.69	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	7882348 8656689 8637248 (more) 15475071
12	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	17.53	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders (show sections)	11919391
13	CEP85L	Centrosomal Protein 85 Like	Protein Coding	16.08	GeneCards inferred via : Disorders Expressions (show sections)
14	RAG1	Recombination Activating 1	Protein Coding	15.46	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8391873
15	BCL2	BCL2 Apoptosis Regulator	Protein Coding	13.82	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
16	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	13.45	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
17	CD8A	CD8a Molecule	Protein Coding	12.88	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
18	PAX5	Paired Box 5	Protein Coding	12.2	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	19145202
19	FGFR1OP2	FGFR1 Oncogene Partner 2	Protein Coding	11.85	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
20	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	11.61	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
21	ADA	Adenosine Deaminase	Protein Coding	11.16	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
22	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	10.99	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
23	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	10.78	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
24	MS4A1	Membrane Spanning 4-Domains A1	Protein Coding	10.67	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11235901
25	MPO	Myeloperoxidase	Protein Coding	10.61	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	7513945 8037168
26	KMT2A	Lysine Methyltransferase 2A	Protein Coding	10.35	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	10602439
27	ENO2	Enolase 2	Protein Coding	10.02	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11190795 2255187 15678916
28	VIM	Vimentin	Protein Coding	9.48	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
29	CEP43	Centrosomal Protein 43	Protein Coding	7.44	GeneCards inferred via : Disorders (show sections)
30	CNTRL	Centriolin	Protein Coding	7.44	GeneCards inferred via : Disorders (show sections)
31	RANBP2	RAN Binding Protein 2	Protein Coding	7.44	GeneCards inferred via : Disorders (show sections)

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Variations for Lymphoblastic Lymphoma

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Expression for Lymphoblastic Lymphoma

Search GEO for disease gene expression data for Lymphoblastic Lymphoma.

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Pathways for Lymphoblastic Lymphoma

Pathways related to Lymphoblastic Lymphoma according to GeneCards Suite gene sharing:

(show all 11)

#	Super pathways	Score	Top Affiliating Genes
1	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.74	PTPRC NOTCH1 CD8A
2	NF-kappaB Signaling ³	11.74	TNFRSF8 TAL1 RAG1 PTPRC PAX5 FLI1
3	DNA damage response (only ATM dependent) ⁷⁴	11.66	CDKN1B BCL6 BCL2
4	Notch Signaling Pathways ⁶⁵	11.63	NOTCH1 BCL6 BCL2
5	Small cell lung cancer ⁷⁴	11.59	CDKN2B CDKN1B BCL2
6	FGFR1 mutant receptor activation ⁶⁶ Show member pathways Signaling by cytosolic FGFR1 fusion mutants ⁶⁶ Signaling by FGFR1 in disease ⁶⁶ Signaling by plasma membrane FGFR1 fusions ⁶⁶	11.53	ZMYM2 FGFR1OP2 FGFR1
7	Innate Lymphoid Cells Differentiation ⁶⁵	11.45	PTPRC CD8A CD7
8	C-MYB transcription factor network ⁶¹	11.4	PAX5 CDKN1B BCL2
9	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.28	PTPRC PAX5 BCL6
10	Validated targets of C-MYC transcriptional repression ⁶¹	11.05	DNTT CDKN2B CDKN1B BCL2
11	Prion disease pathway ⁷⁴	10.84	PAX5 FGFR1 BCL2

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GO Terms for Lymphoblastic Lymphoma

Biological processes related to Lymphoblastic Lymphoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	T cell activation	GO:0042110	9.85	PTPRC CD8A CD7
2	regulation of cell population proliferation	GO:0042127	9.8	TAL1 NOTCH1 CDKN1B BCL6
3	negative regulation of glial cell proliferation	GO:0060253	9.73	NOTCH1 CDKN2B
4	B cell proliferation	GO:0042100	9.73	BCL2 BCL6 PTPRC
5	positive regulation of B cell proliferation	GO:0030890	9.63	PTPRC BCL6 BCL2
6	stem cell development	GO:0048864	9.62	PTPRC BCL2
7	mesenchymal cell development	GO:0014031	9.26	NOTCH1 BCL2
8	B cell differentiation	GO:0030183	9.23	RAG1 PTPRC PAX5 BCL6 BCL2