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MCID: LYM040
MIFTS: 54

Lymphoblastic Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Lymphoblastic Lymphoma

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MalaCards integrated aliases for Lymphoblastic Lymphoma:

Name: Lymphoblastic Lymphoma 12 74 52 15 37
Precursor Cell Lymphoblastic Leukemia Lymphoma 71
Precursor Cell Lymphoblastic Lymphoma 71
Lymphoma, Lymphoblastic 52
Lymphoma Lymphoblastic 54

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Blood diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:0080147
ICD10 32 C83.5
UMLS 71 C0079748 C1961102
Sources

Summaries for Lymphoblastic Lymphoma

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Disease Ontology : 12 A lymphoma that has material basis in immature malignant lymphocytes (lymphoblasts) committed to the B-cell or T-cell lineage and located in primarily lymph nodes or located in extranodal sites.

MalaCards based summary : Lymphoblastic Lymphoma, also known as precursor cell lymphoblastic leukemia lymphoma, is related to precursor b lymphoblastic lymphoma/leukemia and acute t cell leukemia. An important gene associated with Lymphoblastic Lymphoma is DNTT (DNA Nucleotidylexotransferase), and among its related pathways/superpathways are NF-kappaB Signaling and Transcriptional misregulation in cancer. The drugs Dopamine and Methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include primarily lymph nodes, extranodal sites and t cells, and related phenotypes are Reduced mammosphere formation and immune system

Wikipedia : 74 Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the... more...

Sources

Related Diseases for Lymphoblastic Lymphoma

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Diseases related to Lymphoblastic Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 325)
# Related Disease Score Top Affiliating Genes
1 precursor b lymphoblastic lymphoma/leukemia 34.8 DNTT CD7
2 acute t cell leukemia 32.7 TAL1 PTPRC NOTCH1 MYC LMO2 CD7
3 ovarian lymphoma 30.7 MME BCL6
4 lymphocytic leukemia 30.6 TAL1 PTPRC NOTCH1 MYC MME KMT2A
5 myeloproliferative neoplasm 30.6 ZMYM2 MPO KMT2A FGFR1 CEP85L
6 thymoma 30.5 PTPRC NOTCH1 DNTT CD5
7 lymphosarcoma 30.5 TNFRSF8 PTPRC BCL6
8 8p11 myeloproliferative syndrome 30.4 ZMYM2 FGFR1
9 leukemia, acute lymphoblastic 30.4 TAL1 RAG1 PTPRC NOTCH1 MPO MME
10 burkitt lymphoma 30.3 TNFRSF8 MYC MME DNTT CDKN2B BCL6
11 leukemia, acute lymphoblastic 3 30.3 MPO MME KMT2A DNTT CDKN2B
12 leukemia 30.3 TAL1 NOTCH1 MYC MME LMO2 KMT2A
13 follicular lymphoma 30.2 MYC MME CD5 BCL6
14 acute leukemia 30.2 TAL1 MPO KMT2A DNTT CDKN2B CD7
15 pediatric lymphoma 30.2 TNFRSF8 MYC MME BCL6
16 angioimmunoblastic t-cell lymphoma 30.2 TNFRSF8 MME BCL6
17 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 30.1 MPO KMT2A DNTT
18 dendritic cell tumor 30.1 PTPRC MPO DNTT
19 myeloid sarcoma 30.1 PTPRC MPO KMT2A DNTT CD7
20 t-cell leukemia 30.0 TAL1 NOTCH1 MYC LMO2 CDKN2B CD7
21 lymphoma 30.0 ZMYM2 TNFRSF8 TAL1 PTPRC MYC MME
22 precursor t-cell acute lymphoblastic leukemia 30.0 TAL1 NOTCH1 MYC MPO LMO2 KMT2A
23 childhood leukemia 30.0 MPO KMT2A CDKN2B
24 t-cell lymphoma, subcutaneous panniculitis-like 29.9 TNFRSF8 CD7
25 t-cell adult acute lymphocytic leukemia 29.9 TNFRSF8 CD7 CD5
26 myelodysplastic syndrome 29.8 NOTCH1 MYC MPO KMT2A DNTT CDKN2B
27 b-cell lymphoma 29.8 TNFRSF8 PTPRC MYC MME CDKN2B CD5
28 peripheral t-cell lymphoma 29.8 TNFRSF8 PTPRC NOTCH1 MME CD5 BCL6
29 pancytopenia 29.7 PTPRC MPO KMT2A CD7 CD5
30 ewing sarcoma 29.6 TNFRSF8 PTPRC MYC FLI1 FGFR1 DNTT
31 mantle cell lymphoma 29.6 PTPRC NOTCH1 MYC MME CDKN2B CD5
32 leukemia, chronic myeloid 29.6 TAL1 PTPRC MYC MPO KMT2A FGFR1
33 composite lymphoma 29.5 TNFRSF8 MME CD5 BCL6
34 diffuse large b-cell lymphoma 29.5 TNFRSF8 PTPRC MYC MME LMO2 CD5
35 myeloma, multiple 29.1 TNFRSF8 PTPRC NOTCH1 MYC MME CD5
36 plasma cell neoplasm 29.1 TNFRSF8 PTPRC MYC MME CD5 BCL6
37 immune deficiency disease 29.1 TNFRSF8 RAG1 PTPRC CD5 BCL6
38 acute promyelocytic leukemia 28.9 PTPRC NOTCH1 MYC MPO KMT2A CDKN2B
39 leukemia, chronic lymphocytic 28.3 TNFRSF8 PTPRC NOTCH1 MYC MME KMT2A
40 lymphoma, non-hodgkin, familial 28.2 ZMYM2 TNFRSF8 TAL1 RAG1 PTPRC NOTCH1
41 hematologic cancer 28.2 TNFRSF8 PTPRC NOTCH1 MYC MME KMT2A
42 leukemia, acute myeloid 27.8 TNFRSF8 TAL1 PTPRC NOTCH1 MYC MPO
43 t-cell childhood lymphoblastic lymphoma 12.7
44 precursor t-lymphoblastic lymphoma/leukemia 12.5
45 precursor lymphoblastic lymphoma/leukemia 12.4
46 childhood precursor t-lymphoblastic lymphoma/leukemia 12.3
47 chromosome 8p11 myeloproliferative syndrome 11.7
48 pdgfra-associated chronic eosinophilic leukemia 11.4
49 refractory t lymphoblastic leukemia/lymphoma 11.3
50 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.6 ZMYM2 FGFR1

Graphical network of the top 20 diseases related to Lymphoblastic Lymphoma:



Diseases related to Lymphoblastic Lymphoma
Sources

Symptoms & Phenotypes for Lymphoblastic Lymphoma

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GenomeRNAi Phenotypes related to Lymphoblastic Lymphoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.28 BCL6 CD5 CD7 KMT2A LMO2 MYC

MGI Mouse Phenotypes related to Lymphoblastic Lymphoma:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.39 BCL6 CD5 CD7 CDKN2B DNTT FGFR1
2 hematopoietic system MP:0005397 10.38 BCL6 CD5 CD7 CDKN2B DNTT FGFR1
3 cellular MP:0005384 10.29 BCL6 CDKN2B FGFR1 FLI1 KMT2A LMO2
4 cardiovascular system MP:0005385 10.26 BCL6 FGFR1 FLI1 KMT2A LMO2 MPO
5 integument MP:0010771 10.21 BCL6 CD5 CDKN2B FGFR1 KMT2A LMO2
6 endocrine/exocrine gland MP:0005379 10.19 BCL6 CD7 CDKN2B FGFR1 FLI1 MYC
7 mortality/aging MP:0010768 10.18 BCL6 CDKN2B FGFR1 FLI1 KMT2A LMO2
8 liver/biliary system MP:0005370 10.06 BCL6 FLI1 KMT2A LMO2 MME MYC
9 nervous system MP:0003631 10 CD5 FGFR1 FLI1 KMT2A LMO2 MME
10 neoplasm MP:0002006 9.92 CDKN2B FLI1 KMT2A LMO2 MYC NOTCH1
11 no phenotypic analysis MP:0003012 9.7 BCL6 CD5 CDKN2B FGFR1 KMT2A MYC
12 normal MP:0002873 9.61 BCL6 CD5 DNTT FGFR1 KMT2A MYC
13 renal/urinary system MP:0005367 9.23 CDKN2B FGFR1 KMT2A LMO2 NOTCH1 PTPRC
Sources

Drugs & Therapeutics for Lymphoblastic Lymphoma

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Drugs for Lymphoblastic Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 519)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
3
Posaconazole Approved, Investigational, Vet_approved Phase 4 171228-49-2 147912
4
Micafungin Approved, Investigational Phase 4 235114-32-6 3081921 477468
5
Epirubicin Approved Phase 4 56420-45-2 41867
6
Nicotine Approved Phase 4 54-11-5 942 89594
7
Teniposide Approved Phase 4 29767-20-2 34698
8
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
9
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
10
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
11
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
12
Calcifediol Approved, Nutraceutical Phase 4 19356-17-3 6433735 5283731
13
Ethylene Phase 4 74-85-1 6325
14 Dopamine Uptake Inhibitors Phase 4
15 Dopamine Agents Phase 4
16 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
17 Ergocalciferols Phase 4
18 Calciferol Phase 4
19 Vitamin D2 Phase 4
20 Hydroxycholecalciferols Phase 4
21 Cytochrome P-450 CYP3A Inhibitors Phase 4
22 Steroid Synthesis Inhibitors Phase 4
23 Cytochrome P-450 CYP2C9 Inhibitors Phase 4
24 Liposomal amphotericin B Phase 4
25 Orange Approved Phase 3
26
Cefepime Approved, Investigational Phase 3 88040-23-7 5479537
27
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
28
Morphine Approved, Investigational Phase 3 57-27-2 5288826
29
Dactinomycin Approved, Investigational Phase 3 50-76-0 2019 457193
30
Cobalt Approved, Experimental Phase 3 7440-48-4 104729
31
Iron Approved, Experimental Phase 3 7439-89-6, 15438-31-0 23925 27284
32
Calcium carbonate Approved, Investigational Phase 3 471-34-1
33
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
34
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
35
Ofloxacin Approved Phase 3 82419-36-1 4583
36
Carvedilol Approved, Investigational Phase 3 72956-09-3 2585
37
Enalaprilat Approved Phase 3 76420-72-9 6917719
38
Enalapril Approved, Vet_approved Phase 3 75847-73-3 5362032 40466924
39
Acyclovir Approved Phase 3 59277-89-3 2022
40
Piperacillin Approved Phase 3 66258-76-2 43672
41
Tazobactam Approved Phase 3 89786-04-9 123630
42
Vancomycin Approved Phase 3 1404-90-6 441141 14969
43
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
44
Dalteparin Approved Phase 3 9005-49-6
45
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
46
Ribavirin Approved Phase 3 36791-04-5 37542
47
Palivizumab Approved, Investigational Phase 3 188039-54-5
48
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
49
Captopril Approved Phase 3 62571-86-2 44093
50
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365

Interventional clinical trials:

(show top 50) (show all 1814)
# Name Status NCT ID Phase Drugs
1 Multicenter Study To Optimize Treatment in Elderly Patients (> 55 Years, No Upper Age Limit) With Acute Lymphoblastic Leukemia (GMALL Elderly 1/2003)(Amend 2) Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
2 German Multicenter Study for Treatment Optimisation in Acute Lymphoblastic Leukemia in Adults and Adolescents Above 15 Years (Amend 3) (GMALL 07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
3 Ma-Spore ALL 2010 Study Unknown status NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
4 Philadelphia -Negative High-risk Children Acute Lymphoblastic Leukemia(ALL) Treatment:Induction Therapy:Vincristine(V),Idarubicin(I),L-asparaginase(L),Dexamethasone(D);Consolidation:V+Daunorubicin(D)+L+D, Methotrexate,Cytarabine Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
5 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
6 PEG-asparaginase During Two Treatment Courses in the Treatment of Childhood Acute Lymphoblastic Leukemia Unknown status NCT00192673 Phase 4 PEG-asparaginase
7 Medical Research Council Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
8 The Combination of Lower Dosage of Chemotherapy With Tyrosine Kinase Inhibitor to Treat Newly Diagnosed ph+ Acute Lymphoblastic Leukemia Patients Unknown status NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
9 Clinical Study of GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia in Guangdong Province Unknown status NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
10 An Open-label,Multi-center,Prospective Study of Idarubicin and Etoposide Intensified Conditioning Regimen Allogeneic Hematopoietic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
11 Multicenter Trial for Treatment Optimization in T-lymphoblastic Lymphoma in Adults and Adolescents Older Than 15 Years (GMALL T-LBL 1/2004) (Amend 1) Completed NCT00199017 Phase 4 Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
12 Multicenter Study to Optimise Therapy of B-ALL, Burkitt's NHL and High-Grade Non-Hodgkin's Lymphoma in Adults (Amend 7) Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
13 The Study on the Pharmacokinetics of Pegylated Recombinant Human Granulocyte Stimulating Factor（PEG-rhG-CSF） in Children and Adolescents Completed NCT02953730 Phase 4 PEG-rhG-CSF
14 Pilot Study for Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
15 Multicenter Trial for Treatment of Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
16 Multicenter Trial for Treatment of Acute Lymphocytic Leukemia in Adults (Pilot Study 06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
17 German Multicenter Trial for Treatment Optimisation in Acute Lymphoblastic Leukemia in Adults and Adolescents Above 15 Years With Rituximab for Improvement of Prognosis in CD20 Positive Standard Risk ALL (Amend 2) Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
18 Pulses of Vincristine and Dexamethasone During Maintenance in BFM Protocols for Children With Intermediate-Risk Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
19 A Randomized Open-Label Trial of Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Completed NCT01200355 Phase 4 micafungin;posaconazole
20 Prospective Study of Rituximab Combined With Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
21 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4 Methylphenidate
22 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin;Mercaptopurine;Prednisone;Vincristine;Methotrexate
23 LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive Completed NCT00526305 Phase 4 Vincristine;Daunorubicin;Prednisone;L-Asparaginase;Mitoxantrone;Cytosine Arabinoside;Hydrocortisone;Mercaptopurine;Cyclophosphamide;Dexamethasone
24 LAL-BR/2001: Study Treatment to Low Risk ALL Completed NCT00526175 Phase 4 Prednisone;Vincristine;Daunorubicin;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside;Mercaptopurine;VP-16
25 ALL-REZ BFM 2002: Protocol for the Treatment of Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
26 LAL-AR-N-2005: Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4 Prednisolone;Daunorubicin;Vincristine;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside
27 Evaluation of Allogeneic Marrow Transplants Depleted of T-Cells by CD34+ Selection in Patients Undergoing Transplantation With an Unrelated Matched or 1 Antigen Mismatched Donor or a 1 Antigen Mismatched Related Donor Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
28 A Clinical Trial of Decitabine Combined With CODOX-M/IVAC in Relapsed or Refractory T-lymphoblastic Lymphoma Recruiting NCT03558412 Phase 4 Decitabine
29 A PHASE 4, OPEN-LABEL, RANDOMIZED STUDY OF TWO INOTUZUMAB OZOGAMICIN DOSE LEVELS IN ADULT PATIENTS WITH RELAPSED OR REFRACTORY B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA ELIGIBLE FOR HEMATOPOIETIC STEM CELL TRANSPLANTATION AND WHO HAVE RISK FACTOR(S) FOR VENO-OCCLUSIVE DISEASE Recruiting NCT03677596 Phase 4 inotuzumab ozogamicin-dose level 2;Inotuzumab ozogamicin-dose level 1
30 Hematology , Shanghai Jiaotong University Affiliated Shanghai First People's Hospital, Shanghai, China Recruiting NCT02938741 Phase 4 Anti－human Thymoglobulin;Placebo
31 G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor: a Prospective, Multicentre, Randomised Controlled Trial Recruiting NCT02933333 Phase 4
32 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
33 Plasma Kinetics of Tablet and Liquid Formulations of 6-mercaptopurine in Childhood Acute Lymphoblastic Leukemia. Recruiting NCT01906671 Phase 4 Xaluprine;Puri-Nethol
34 Allogeneic Stem Cell Transplant for Children and Adolescents With Acute Lymoblastic Leukemia FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
35 PROTOCOL FOR THE TREATMENT Acute Lymphoblastic Leukemia With Ph 'NEGATIVE IN ELDERLY PATIENTS (> 55 Years) Recruiting NCT01366898 Phase 4 Dexamethasona, Idarubicine, ARA-C, Methotrexate
36 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
37 Treatment Protocol For All Fragile Patients Ph' Negative Over 55 Years Recruiting NCT01358201 Phase 4 vINCRISTINE;Dexamethasone;Methotrexate;Cytosine arabinoside
38 Vaccinating Children After Chemotherapy for Acute Lymphoblastic Leukemia: A Canadian Immunization Research Network Study Active, not recruiting NCT02447718 Phase 4
39 Treatment of High Risk Adult Acute Lymphoblastic Leukemia Active, not recruiting NCT00853008 Phase 4 Vincristine;Daunorubicin;Prednisone;Mitoxantrone;Cytosine Arabinoside;Dexamethasone;Methotrexate (MTX);Cytarabine;ASP;Mercaptopurine;Teniposide;Hydrocortisone
40 Determinants of Mercaptopurine Toxicity in Paediatric Acute Lymphoblastic Enrolling by invitation NCT03920813 Phase 4 Mercaptopurine
41 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 (Stoss Therapy) in Pediatric Patients Undergoing HSCT to Prevent Vitamin D Deficiency and Insufficiency During Transplant Enrolling by invitation NCT03176849 Phase 4
42 ProphyALL - Pilot Study on Safety of Four Weekly Administrations of 7 mg/kg of Liposomal Amphotericin B (AmBisome®) in Antifungal Primary Prophylaxis Treatment of Elderly Patients With Acute Lymphoblastic Leukemia Undergoing Induction Chemotherapy Within the GMALL-Elderly Protocol Terminated NCT00386997 Phase 4 liposomal amphotericin B (AmBisome®)
43 Phase III Study of Vincristine Sulfate Liposome Or Vincristine Sulfate For Injection Combined Chemotherapy as Initial Induction Regimen In Adults Acute Lymphoblastic Leukemia Unknown status NCT02072785 Phase 3 Vincristine Sulfate Liposome;Vincristine Sulfate
44 A Phase-2 Clinical Study to Determine the Efficacy and Safety of Depocyt (Cytarabine Liposome Injection) for the Treatment of CNS Relapse in Adult Patients With Acute Lymphoblastic Leukemia or Very Aggressive Lymphoma Unknown status NCT00199108 Phase 2, Phase 3 Depocyt;Dexamethasone
45 Randomized Controlled Trial to Test Efficacy of High-Dose Methotrexate Consolidation Therapy for BCR-ABL-Negative Acute Lymphoblastic Leukemia in Adults Unknown status NCT00131027 Phase 3 Cyclophosphamide;Daunorubicin;Vincristine;Prednisolone;L-asparaginase;Cytarabine;Etoposide;Dexamethasone;Methotrexate;Mercaptopurine;Doxorubicin;Methotrexate
46 Evaluation of Benefit and Side Effects of Double Umbilical Cord Blood Units Stem Cell Transplantation in Hematologic Malignancies Unknown status NCT01015742 Phase 2, Phase 3 Stem cell Transplantation
47 Busulfan Plus Cyclophosphamide vs Total Body Irradiation Plus Cyclophosphamide Conditioning Regimen for Standard-risk Acute Lymphocytic Leukemia Undergoing HLA-matched Allogeneic Hematopoietic Stem Cell Transplantation Unknown status NCT02670252 Phase 2, Phase 3 Busulfan (BU);Cyclophosphamide (CY)
48 The Value of Dexamethasone Versus Prednisolone During Induction and Maintenance Therapy of Prolonged Versus Conventional Duration of L-Asparaginase Therapy During Consolidation and Late Intensification, and of Corticosteroid + VCR Pulses During Maintenance in Acute Lymphoblastic Leukemia and Lymphoblastic Non-Hodgkin Lymphoma of Childhood Unknown status NCT00003728 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisolone;therapeutic hydrocortisone;thioguanine;vincristine sulfate;vindesine
49 Pegylated Liposomal Doxorubicin-contained Versus Daunorubicin-contained VDCLD Regimen in Previously Untreated Adult Patients With Acute Lymphoblastic Leukemia: Complete Remission Rates and Changes of Leukemia Stem Cells Unknown status NCT02070523 Phase 3 VDCLD regimen
50 Allogeneic Stem Cell Transplantation in Children and Adolescents With Acute Lymphoblastic Leukaemia Unknown status NCT01423747 Phase 3 VP16;VP16, ATG;Fludarabine, OKT3, Treosulfan, Thiotepa;VP16, ATG

Search NIH Clinical Center for Lymphoblastic Lymphoma

Inferred drug relations via UMLS 71 / NDF-RT 50 :


ASPARAGINASE
Cyclophosphamide
Idarubicin
Idarubicin Hydrochloride
Ifosfamide
mercaptopurine
pegaspargase
sargramostim

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Lymphoblastic Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Lymphoblastic Lymphoma:
Blood stem cell transplantation for hematological diseases
Peripheral blood stem cells for treatment of hematologic malignancies
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Lymphoblastic Lymphoma:
Bone marrow-derived hematopoietic stem cells
Peripheral blood-derived hematopoietic stem cells (family)
Sources

Genetic Tests for Lymphoblastic Lymphoma

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Sources

Anatomical Context for Lymphoblastic Lymphoma

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The Foundational Model of Anatomy Ontology organs/tissues related to Lymphoblastic Lymphoma:

19
Primarily Lymph Nodes, Extranodal Sites

MalaCards organs/tissues related to Lymphoblastic Lymphoma:

40
T Cells, B Cells, Bone, Bone Marrow, Myeloid, B Lymphoblasts, Lymph Node
Sources

Publications for Lymphoblastic Lymphoma

About this section

Articles related to Lymphoblastic Lymphoma:

(show top 50) (show all 1934)
# Title Authors PMID Year
1
Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of t(14;18)-negative follicular lymphoma. 54 61
19633642 2009
2
Immunohistochemical evaluation of FLI-1 in acute lymphoblastic lymphoma (ALL): a potential diagnostic pitfall. 54 61
19349856 2009
3
PAX immunoreactivity identifies alveolar rhabdomyosarcoma. 54 61
19145202 2009
4
K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors. 54 61
18663146 2008
5
Reactivity with TdT in Merkel cell carcinoma: a potential diagnostic pitfall. 54 61
18480005 2008
6
A six-year-old boy with a suspicious thyroid nodule: intrathyroidal thymic tissue. 54 61
18341382 2008
7
TdT expression in Merkel cell carcinoma: potential diagnostic pitfall with blastic hematological malignancies and expanded immunohistochemical analysis. 54 61
17885674 2007
8
CD26, together with cell surface adenosine deaminase, is selectively expressed on ALK-positive, but not on ALK-negative, anaplastic large cell lymphoma and Hodgkin's lymphoma. 54 61
17071493 2006
9
Primary malignant lymphoma of the central nervous system in an immunocompetent child: a case report. 54 61
16217262 2005
10
Methylation status of cyclin-dependent kinase inhibitor genes within the transforming growth factor beta pathway in human T-cell lymphoblastic lymphoma/leukemia. 54 61
15475071 2004
11
[NSE-positive lymphoblastic lymphoma in a boy with cutaneous involvement, giant splenomegaly, and hyper-gamma globulinemia]. 54 61
15678916 2004
12
[Pathologic diagnoses of core needle biopsies of the mediastinum]. 54 61
15132850 2004
13
CD26 expression correlates with a reduced sensitivity to 2'-deoxycoformycin-induced growth inhibition and apoptosis in T-cell leukemia/lymphomas. 54 61
14760072 2004
14
Immunohistochemical expression of the transcription factor DP-1 and its heterodimeric partner E2F-1 in non-Hodgkin lymphoma. 54 61
12607600 2002
15
The 8p11 myeloproliferative syndrome: a distinct clinical entity caused by constitutive activation of FGFR1. 54 61
11919391 2002
16
Peripheral T-cell lymphoma with aberrant expression of CD79a and CD20: a diagnostic pitfall. 54 61
11235901 2001
17
BCL-6 protein is expressed in precursor T-cell lymphoblastic lymphoma and in prenatal and postnatal thymus. 54 61
11133771 2001
18
Ewing sarcoma vs lymphoblastic lymphoma. A comparative immunohistochemical study. 54 61
11190795 2001
19
Therapy-related T cell lymphoblastic lymphoma with t(11;19)(q23;p13) and MLL gene rearrangement. 54 61
10602439 1999
20
Lymphoblastic lymphoma expressing CD56 and TdT. 54 61
9422326 1998
21
MIC2, TdT, bcl-2, and CD34 expression in paraffin-embedded high-grade lymphoma/acute lymphoblastic leukemia distinguishes between distinct clinicopathologic entities. 54 61
9343323 1997
22
An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice. 54 61
9171354 1997
23
Terminal deoxynucleotidyl transferase staining of malignant lymphomas in paraffin sections: a useful method for the diagnosis of lymphoblastic lymphoma. 54 61
9227346 1997
24
Defects of the mismatch repair gene MSH2 are implicated in the development of murine and human lymphoblastic lymphomas and are associated with the aberrant expression of rhombotin-2 (Lmo-2) and Tal-1 (SCL). 54 61
9116269 1997
25
Lymphoblastic lymphoma expressing natural killer cell phenotype with involvement of the mediastinum and nasal cavity. 54 61
9042293 1997
26
Application of rearrangements of T cell receptor gene in the diagnosis of mediastinal T-lymphoblastic lymphoma: a case report. 54 61
9175304 1997
27
A T cell lymphoblastic lymphoma patient with two malignant cell populations carrying different 9p deletions including the p16INK4 and p15INK4B genes: Clinical response to interferon-alpha therapy in one of the subclones. 54 61
8656689 1996
28
Expression pattern of CD45 RA/RO isoformic antigens in T-lineage neoplasms. 54 61
7741140 1995
29
Involvement of CDKN2 (p16INK4A/MTS1) and p15INK4B/MTS2 in human leukemias and lymphomas. 54 61
7882348 1995
30
Terminal deoxynucleotidyl transferase staining of malignant lymphomas in paraffin sections. 54 61
7937725 1994
31
Lineage determination of CD7+ CD5- CD2- and CD7+ CD5+ CD2- lymphoblasts: studies on phenotype, genotype, and gene expression of myeloperoxidase, CD3 epsilon, and CD3 delta. 54 61
7513945 1994
32
Small cell osteosarcoma of bone: an immunohistochemical study with differential diagnostic considerations. 54 61
7503935 1993
33
Human recombination activating gene-1 in leukemia/lymphoma cells: expression depends on stage of lymphoid differentiation defined by phenotype and genotype. 54 61
8391873 1993
34
Emergence of a B-cell lymphoblastic lymphoma in a patient with B-cell chronic lymphocytic leukemia: evidence for the single-cell origin of the two tumors. 54 61
1859892 1991
35
Flow cytometric analysis of terminal deoxynucleotidyl transferase. 54 61
1996546 1991
36
Expression of enolases in T cell tumors and Hodgkin's disease. 54 61
2255187 1990
37
Genuine CD7 expression in acute leukemia and lymphoblastic lymphoma. 54 61
1701841 1990
38
The association of mediastinal mass in the formation of thrombi in pediatric patients with non-lymphoblastic lymphomas. 61
31736198 2020
39
Multiple heterogeneous bone invasions of B lymphoblastic lymphoma with the TCF3/PBX1 fusion gene: a case report. 61
31828595 2020
40
Severe chemotherapy toxicity in a 10-year-old with T-acute lymphoblastic lymphoma harboring biallelic FANCM variants. 61
31942822 2020
41
Sustained remission in a patient with PDGFR-beta-rearranged T-lymphoblastic lymphoma and complete remission with dasatinib. 61
31571404 2020
42
Chromosome Translocation t(14;21)(q11;q22) Activates Both OLIG1 and OLIG2 in Pediatric T-cell Lymphoblastic Malignancies and May Signify Adverse Prognosis. 61
31882550 2020
43
Anesthetic management during anterior mediastinal mass resection in a pediatric patient. A case report. 61
31776014 2020
44
Morphologic and Immunohistochemical Characterization of Spontaneous Lymphoma/Leukemia in NSG Mice. 61
31736441 2020
45
Molecular and phenotypic characterization of an early T-cell precursor acute lymphoblastic lymphoma harboring PICALM-MLLT10 fusion with aberrant expression of B-cell antigens. 61
31739126 2020
46
How I treat newly diagnosed T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma in children. 61
31738819 2020
47
Pitfalls of FNA diagnosis of thymic tumors. 61
31742902 2020
48
Desensitization to pegaspargase in children with acute lymphoblastic leukemia and lymphoblastic lymphoma. 61
31571395 2020
49
Functional characterization of two rare BCR-FGFR1+ leukemias. 61
31980503 2020
50
Tatton-Brown-Rahman syndrome: Six individuals with novel features. 61
31961069 2020
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Variations for Lymphoblastic Lymphoma

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Expression for Lymphoblastic Lymphoma

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Search GEO for disease gene expression data for Lymphoblastic Lymphoma.
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Pathways for Lymphoblastic Lymphoma

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Pathways related to Lymphoblastic Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
NF-kappaB Signaling 4
12.01 TNFRSF8 TAL1 RAG1 PTPRC MPO FLI1
2
Transcriptional misregulation in cancer 36
11.9 MYC MPO LMO2 KMT2A FLI1 BCL6
3
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.72 PTPRC NOTCH1 MPO MME CD5
4
Neural Crest Differentiation 1
11.62 NOTCH1 MYC FGFR1
5
Hematopoietic cell lineage 36
11.62 MME DNTT CD7 CD5
6
Validated targets of C-MYC transcriptional repression 1
11.37 MYC DNTT CDKN2B
7
Hematopoietic Stem Cell Differentiation 1
11.23 NOTCH1 LMO2 FLI1
8
B Cell Development Pathways 64
10.75 TNFRSF8 PTPRC MME CD5 BCL6
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GO Terms for Lymphoblastic Lymphoma

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Biological processes related to Lymphoblastic Lymphoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 9.85 ZMYM2 TAL1 NOTCH1 MYC FLI1 BCL6
2 regulation of gene expression GO:0010468 9.71 PTPRC NOTCH1 MYC FGFR1
3 lung development GO:0030324 9.63 NOTCH1 MME FGFR1
4 B cell differentiation GO:0030183 9.5 RAG1 PTPRC BCL6
5 positive regulation of transcription by RNA polymerase II GO:0045944 9.5 TAL1 NOTCH1 MYC LMO2 KMT2A FLI1
6 megakaryocyte development GO:0035855 9.49 TAL1 FLI1
7 embryonic hemopoiesis GO:0035162 9.48 TAL1 KMT2A
8 regulation of cell proliferation GO:0042127 9.46 TAL1 NOTCH1 FGFR1 BCL6
9 generation of neurons GO:0048699 9.43 TAL1 FGFR1
10 regulation of hematopoietic stem cell differentiation GO:1902036 9.43 TAL1 LMO2 KMT2A
11 megakaryocyte differentiation GO:0030219 8.62 TAL1 CDKN2B

Molecular functions related to Lymphoblastic Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.25 ZMYM2 TNFRSF8 TAL1 RAG1 PTPRC NOTCH1
2 DNA-binding transcription factor activity GO:0003700 9.73 TAL1 NOTCH1 MYC KMT2A FLI1 BCL6
3 chromatin binding GO:0003682 9.55 TAL1 NOTCH1 MPO FLI1 BCL6
4 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 9.54 TAL1 KMT2A FLI1
5 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.17 ZMYM2 TAL1 MYC LMO2 KMT2A FLI1
6 E-box binding GO:0070888 9.13 TAL1 MYC LMO2
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Sources for Lymphoblastic Lymphoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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