LCM
MCID: LYM009
MIFTS: 45

Lymphocytic Choriomeningitis (LCM)

Categories: Genetic diseases, Immune diseases, Infectious diseases

Aliases & Classifications for Lymphocytic Choriomeningitis

MalaCards integrated aliases for Lymphocytic Choriomeningitis:

Name: Lymphocytic Choriomeningitis 12 56 45 15 74 3
Lymphocytic Choriomeningitis Virus Encephalomyelitis 12
Non-Arthropod Borne Lymphocytic Choriomeningitis 74
Lymphocytic Meningoencephalitis 12
Lymphocytic Meningitis 12
Lcm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12155
MeSH 45 D008216
SNOMED-CT 69 38666007
ICD10 34 A87.2

Summaries for Lymphocytic Choriomeningitis

Disease Ontology : 12 A viral infectious disease that results in infection located in brain, or located in meninges, or located in brain and meninges, has material basis in Lymphocytic choriomeningitis virus, which is transmitted by common house mouse, Mus musculus. The infection has symptom fever, has symptom lack of appetite, has symptom headache, has symptom muscle aches, has symptom malaise, has symptom nausea, and has symptom vomiting.

MalaCards based summary : Lymphocytic Choriomeningitis, also known as lymphocytic choriomeningitis virus encephalomyelitis, is related to lassa fever and mollaret meningitis. An important gene associated with Lymphocytic Choriomeningitis is DAG1 (Dystroglycan 1), and among its related pathways/superpathways is African trypanosomiasis. The drugs Vaccines and Antiviral Agents have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spleen, and related phenotypes are Decreased vesicular stomatitis virus (VSV) infection and Decreased vesicular stomatitis virus (VSV) infection

CDC : 3 Lymphocytic choriomeningitis, or LCM, is a rodent-borne viral infectious disease caused by lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae, that was initially isolated in 1933.

Wikipedia : 77 Lymphocytic choriomeningitis (LCM) is a rodent-borne viral infectious disease that presents as aseptic... more...

Related Diseases for Lymphocytic Choriomeningitis

Diseases related to Lymphocytic Choriomeningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 lassa fever 30.4 AXL DAG1
2 mollaret meningitis 12.0
3 mantle cell lymphoma 11.4
4 meningitis 10.4
5 leukemia 10.3
6 rabies 10.3
7 hepatitis 10.3
8 hydrocephalus 10.3
9 central nervous system disease 10.3
10 influenza 10.3
11 nervous system disease 10.3
12 growth hormone deficiency 10.3
13 glomerulonephritis 10.2
14 meningoencephalitis 10.2
15 pertussis 10.2
16 vaccinia 10.2
17 encephalitis 10.2
18 la crosse encephalitis 10.2 AXL TYRO3
19 cerebellar hypoplasia 10.2
20 chorioretinitis 10.2
21 stomatitis 10.2
22 mumps 10.1
23 aseptic meningitis 10.1
24 mesangial proliferative glomerulonephritis 10.0 AXL IL6
25 mesenteric lymphadenitis 10.0 IL6 MYD88
26 lymphoma 10.0
27 parotitis 10.0
28 orchitis 10.0
29 retinitis 10.0
30 herpes simplex 10.0
31 toxoplasmosis 10.0
32 glioma 10.0
33 hemorrhagic fever 10.0
34 cytomegalovirus infection 10.0
35 monoclonal gammopathy of uncertain significance 10.0 IL6 MYD88
36 paracoccidioidomycosis 10.0 IL6 MYD88
37 macroglobulinemia 9.9 IL6 MYD88
38 parainfluenza virus type 3 9.9 NOP56 PPP1R15B SLC9A3
39 multiple sclerosis 9.9
40 anemia, autoimmune hemolytic 9.9
41 neuroblastoma 9.9
42 aplastic anemia 9.9
43 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 9.9
44 lymphatic malformation 7 9.9
45 lymphoproliferative syndrome 3 9.9
46 diabetes mellitus 9.9
47 hemolytic anemia 9.9
48 malignant glioma 9.9
49 trypanosomiasis 9.9
50 louping ill 9.9

Graphical network of the top 20 diseases related to Lymphocytic Choriomeningitis:



Diseases related to Lymphocytic Choriomeningitis

Symptoms & Phenotypes for Lymphocytic Choriomeningitis

GenomeRNAi Phenotypes related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-1 9.7 GBF1 NOP56 NRL PIWIL3 PPP1R15B SLC9A3
2 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-2 9.7 GBF1 NOP56 NRL PIWIL3 PPP1R15B SLC9A3
3 Decreased human parainfluenza virus type 3 (HPIV3) infection GR00241-A-4 9.46 GBF1 NOP56 PPP1R15B SLC9A3
4 Decreased lymphocytic choriomeningitis virus (LCMV) infection GR00241-A-3 9.43 GBF1 NOP56 NRL PIWIL3 PPP1R15B SLC9A3

MGI Mouse Phenotypes related to Lymphocytic Choriomeningitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 AXL DAG1 DDX3X IL6 MYD88 SLC9A3
2 homeostasis/metabolism MP:0005376 9.65 AXL CLEC4G DAG1 DDX3X IL6 MYD88
3 vision/eye MP:0005391 9.1 AXL DAG1 IL6 MYD88 NRL TYRO3

Drugs & Therapeutics for Lymphocytic Choriomeningitis

Drugs for Lymphocytic Choriomeningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2,Phase 1
2 Antiviral Agents Phase 2
3 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study of CMV Vaccine (HB-101) in Kidney Transplant Patients Recruiting NCT03629080 Phase 2
2 Trial to Evaluate Safety and Immunogenicity of a Vaccine Against HCMV Completed NCT02798692 Phase 1

Search NIH Clinical Center for Lymphocytic Choriomeningitis

Cochrane evidence based reviews: lymphocytic choriomeningitis

Genetic Tests for Lymphocytic Choriomeningitis

Anatomical Context for Lymphocytic Choriomeningitis

MalaCards organs/tissues related to Lymphocytic Choriomeningitis:

42
T Cells, Brain, Spleen, Kidney, B Cells, Liver, Testes

Publications for Lymphocytic Choriomeningitis

Articles related to Lymphocytic Choriomeningitis:

(show top 50) (show all 1026)
# Title Authors Year
1
Immune Exhaustion: Past Lessons and New Insights from Lymphocytic Choriomeningitis Virus. ( 30781904 )
2019
2
Lymphocytic Choriomeningitis Virus Infection Demonstrates Higher Replicative Capacity and Decreased Antiviral Response in the First-Trimester Placenta. ( 30882005 )
2019
3
Dynamics of Lymphocyte Reconstitution After Hematopoietic Transplantation During Chronic Lymphocytic Choriomeningitis Virus Infection. ( 29620933 )
2018
4
Inhibition of the Fibrinogen-Like Protein 2:FcI^RIIB/RIII immunosuppressive pathway enhances antiviral T-cell and B-cell responses leading to clearance of lymphocytic choriomeningitis virus clone 13. ( 29341118 )
2018
5
Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection. ( 29593047 )
2018
6
Osteoblasts Are Rapidly Ablated by Virus-Induced Systemic Inflammation following Lymphocytic Choriomeningitis Virus or Pneumonia Virus of Mice Infection in Mice. ( 29212906 )
2018
7
Hypoxic marker CA IX and adhesion mediator I^-catenin are downregulated by lymphocytic choriomeningitis virus persistent infection. ( 29560117 )
2018
8
Replication-incompetent rabies virus vector harboring glycoprotein gene of lymphocytic choriomeningitis virus (LCMV) protects mice from LCMV challenge. ( 29659579 )
2018
9
Lymphocytic choriomeningitis virus infection of dendritic cells interferes with TLR-induced IL-12/IL-23 cytokine production in an IL-10 independent manner. ( 29602153 )
2018
10
Crystal structures of <i>Lymphocytic choriomeningitis virus</i> endonuclease domain complexed with diketo-acid ligands. ( 29765612 )
2018
11
Effective Treatment of Experimental Lymphocytic Choriomeningitis Virus Infection: Consideration of Favipiravir for use with Infected Organ Transplant Recipients. ( 29762684 )
2018
12
Seroprevalence of lymphocytic choriomeningitis virus and Ljungan virus in Finnish patients with suspected neurological infections. ( 28976562 )
2018
13
Adenovirus Vector Vaccination Impacts NK Cell Rheostat Function following Lymphocytic Choriomeningitis Virus Infection. ( 29514912 )
2018
14
Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na+/K+ transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenaviruses. ( 29462184 )
2018
15
Isolation and genomic characterization of lymphocytic choriomeningitis virus in ticks from northeastern China. ( 29992783 )
2018
16
Lymphocytic choriomeningitis virus Clone 13 infection causes either persistence or acute death dependent on IFN-1, cytotoxic T lymphocytes (CTLs), and host genetics. ( 30061383 )
2018
17
Lymphocytic choriomeningitis virus meningoencephalitis in a renal transplant recipient following exposure to mice. ( 30325104 )
2018
18
Cell-to-cell transmission of lymphocytic choriomeningitis virus MX strain during persistent infection and its influence on cell migration. ( 30472873 )
2018
19
Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain. ( 30557576 )
2018
20
CD47 Expression in Natural Killer Cells Regulates Homeostasis and Modulates Immune Response to Lymphocytic Choriomeningitis Virus. ( 30643501 )
2018
21
IRF9 Prevents CD8<sup>+</sup>T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection. ( 28878077 )
2017
22
Resistance of human plasmacytoid dendritic CAL-1 cells to infection with lymphocytic choriomeningitis virus (LCMV) is caused by restricted virus cell entry, which is overcome by contact of CAL-1 cells with LCMV-infected cells. ( 28843812 )
2017
23
Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein. ( 29261807 )
2017
24
Visualization of the lymphocytic choriomeningitis mammarenavirus (LCMV) genome reveals the early endosome as a possible site for genome replication and viral particle pre-assembly. ( 28949905 )
2017
25
Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens. ( 27899229 )
2017
26
Additive Protection against Congenital Cytomegalovirus Conferred by Combined Glycoprotein B/pp65 Vaccination Using a Lymphocytic Choriomeningitis Virus Vector. ( 27795301 )
2017
27
Microcephaly Caused by Lymphocytic Choriomeningitis Virus. ( 28820372 )
2017
28
Semi-Functional Quantitative Flow Cytometry Assay for Lymphocytic Choriomeningitis Virus Titration. ( 29093652 )
2017
29
Congenital Lymphocytic Choriomeningitis Virus: A Case of Prenatal Diagnosis. ( 28858375 )
2017
30
Congenital lymphocytic choriomeningitis virus-an underdiagnosed fetal teratogen. ( 29274373 )
2017
31
Extrinsic Protein Tyrosine Phosphatase Non-Receptor 22 Signals Contribute to CD8 T Cell Exhaustion and Promote Persistence of Chronic Lymphocytic Choriomeningitis Virus Infection. ( 28747914 )
2017
32
CD30 Is Dispensable for T-Cell Responses to Influenza Virus and Lymphocytic Choriomeningitis Virus Clone 13 but Contributes to Age-Associated T-Cell Expansion in Mice. ( 28993768 )
2017
33
Farnesoid X Receptor in Mice Prevents Severe Liver Immunopathology During Lymphocytic Choriomeningitis Virus Infection. ( 28214859 )
2017
34
High clinical suspicion of donor-derived disease leads to timely recognition and early intervention to treat solid organ transplant-transmitted lymphocytic choriomeningitis virus. ( 28423464 )
2017
35
Lymphocytic choriomeningitis, Ljungan and orthopoxvirus seroconversions in patients hospitalized due to acute Puumala hantavirus infection. ( 27721109 )
2016
36
Generation of Lymphocytic Choriomeningitis Virus Based Vaccine Vectors. ( 27076310 )
2016
37
Identification of lymphocytic choriomeningitis mammarenavirus in house mouse (Mus musculus, Rodentia) in French Guiana. ( 26631809 )
2016
38
Residues K465 and G467 within the Cytoplasmic Domain of GP2 Play a Critical Role in the Persistence of Lymphocytic Choriomeningitis Virus in Mice. ( 27581982 )
2016
39
T-Cells Underlie Some but Not All of the Cerebellar Pathology in a Neonatal Rat Model of Congenital Lymphocytic Choriomeningitis Virus Infection. ( 27667772 )
2016
40
Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice. ( 27404802 )
2016
41
Notes from the Field: Lymphocytic Choriomeningitis Virus Meningoencephalitis from a Household Rodent Infestation - Minnesota, 2015. ( 26963688 )
2016
42
Lymphocytic choriomeningitis virus: ways to establish and maintain non-cytolytic persistent infection. ( 26982463 )
2016
43
Replication-defective lymphocytic choriomeningitis virus vectors expressing guinea pig cytomegalovirus gB and pp65 homologs are protective against congenital guinea pig cytomegalovirus infection. ( 26973071 )
2016
44
Dendritic Cells Are Dispensable for T Cell Priming and Control of Acute Lymphocytic Choriomeningitis Virus Infection. ( 27549169 )
2016
45
The Lymphocytic Choriomeningitis Virus Matrix Protein PPXY Late Domain Drives the Production of Defective Interfering Particles. ( 27010636 )
2016
46
Development and application of ELISA for the detection of IgG antibodies to lymphocytic choriomeningitis virus. ( 27265463 )
2016
47
Differential Inhibition of Macrophage Activation by Lymphocytic Choriomeningitis Virus and Pichinde Virus Is Mediated by the Z Protein N-Terminal Domain. ( 26423945 )
2015
48
Lymphocytic Choriomeningitis Virus Expands a Population of NKG2D+CD8+ T Cells That Exacerbates Disease in Mice Coinfected with Leishmania major. ( 26290604 )
2015
49
Peptide motif analysis predicts lymphocytic choriomeningitis virus as trigger for multiple sclerosis. ( 26319106 )
2015
50
Lymphocytic choriomeningitis virus infection induced by percutaneous exposure. ( 26416845 )
2015

Variations for Lymphocytic Choriomeningitis

Expression for Lymphocytic Choriomeningitis

Search GEO for disease gene expression data for Lymphocytic Choriomeningitis.

Pathways for Lymphocytic Choriomeningitis

Pathways related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.19 IL6 MYD88

GO Terms for Lymphocytic Choriomeningitis

Cellular components related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.23 DAG1 DDX3X GBF1 MYD88 NOP56 NRL

Biological processes related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 Wnt signaling pathway GO:0016055 9.73 AXL DDX3X TYRO3
2 regulation of translation GO:0006417 9.71 DDX3X PIWIL3 PPP1R15B
3 platelet activation GO:0030168 9.67 AXL IL6 TYRO3
4 negative regulation of apoptotic process GO:0043066 9.67 AXL DDX3X IL6 MYD88
5 substrate adhesion-dependent cell spreading GO:0034446 9.57 AXL TYRO3
6 protein kinase B signaling GO:0043491 9.55 AXL TYRO3
7 apoptotic cell clearance GO:0043277 9.51 AXL TYRO3
8 natural killer cell differentiation GO:0001779 9.48 AXL TYRO3
9 ovulation cycle GO:0042698 9.46 AXL TYRO3
10 secretion by cell GO:0032940 9.43 AXL TYRO3
11 vagina development GO:0060068 9.4 AXL TYRO3
12 response to peptidoglycan GO:0032494 9.32 IL6 MYD88
13 forebrain cell migration GO:0021885 9.26 AXL TYRO3
14 viral entry into host cell GO:0046718 9.26 AXL CLEC4G DAG1 TYRO3
15 positive regulation of MAPK cascade GO:0043410 9.22 IL6
16 negative regulation of lymphocyte activation GO:0051250 9.16 AXL TYRO3
17 viral process GO:0016032 9.1 AXL CLEC4G DAG1 DDX3X GBF1 TYRO3

Molecular functions related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 AXL CLEC4G DAG1 DDX3X GBF1 IL6
2 Wnt-protein binding GO:0017147 9.26 AXL TYRO3
3 phosphatidylinositol 3-kinase binding GO:0043548 8.96 AXL TYRO3
4 virus receptor activity GO:0001618 8.92 AXL CLEC4G DAG1 TYRO3

Sources for Lymphocytic Choriomeningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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