MCID: LYM009
MIFTS: 45

Lymphocytic Choriomeningitis

Categories: Genetic diseases, Immune diseases, Infectious diseases, Neuronal diseases

Aliases & Classifications for Lymphocytic Choriomeningitis

MalaCards integrated aliases for Lymphocytic Choriomeningitis:

Name: Lymphocytic Choriomeningitis 12 56 3 45 15 74
Lcm 12 3
Lymphocytic Choriomeningitis Virus Encephalomyelitis 12
Non-Arthropod Borne Lymphocytic Choriomeningitis 74
Lymphocytic Meningoencephalitis 12
Lymphocytic Meningitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12155
MeSH 45 D008216
SNOMED-CT 69 38666007
ICD10 34 A87.2

Summaries for Lymphocytic Choriomeningitis

Disease Ontology : 12 A viral infectious disease that results in infection located in brain, or located in meninges, or located in brain and meninges, has material basis in Lymphocytic choriomeningitis virus, which is transmitted by common house mouse, Mus musculus. The infection has symptom fever, has symptom lack of appetite, has symptom headache, has symptom muscle aches, has symptom malaise, has symptom nausea, and has symptom vomiting.

MalaCards based summary : Lymphocytic Choriomeningitis, also known as lcm, is related to lassa fever and mollaret meningitis. An important gene associated with Lymphocytic Choriomeningitis is DAG1 (Dystroglycan 1), and among its related pathways/superpathways are Malaria and African trypanosomiasis. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spleen, and related phenotypes are Decreased vesicular stomatitis virus (VSV) infection and Decreased vesicular stomatitis virus (VSV) infection

CDC : 3 Lymphocytic choriomeningitis, or LCM, is a rodent-borne viral infectious disease caused by lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae, that was initially isolated in 1933.

Wikipedia : 77 Lymphocytic choriomeningitis (LCM) is a rodent-borne viral infectious disease that presents as aseptic... more...

Related Diseases for Lymphocytic Choriomeningitis

Diseases related to Lymphocytic Choriomeningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 lassa fever 30.4 AXL DAG1
2 mollaret meningitis 12.0
3 mantle cell lymphoma 11.5
4 meningitis 10.4
5 leukemia 10.3
6 rabies 10.3
7 hepatitis 10.3
8 hydrocephalus 10.3
9 central nervous system disease 10.3
10 influenza 10.3
11 nervous system disease 10.3
12 growth hormone deficiency 10.3
13 glomerulonephritis 10.3
14 meningoencephalitis 10.3
15 pertussis 10.3
16 vaccinia 10.3
17 encephalitis 10.3
18 cerebellar hypoplasia 10.2
19 chorioretinitis 10.2
20 stomatitis 10.2
21 mumps 10.1
22 aseptic meningitis 10.1
23 lymphoma 10.1
24 parotitis 10.1
25 orchitis 10.1
26 retinitis 10.1
27 herpes simplex 10.1
28 toxoplasmosis 10.1
29 glioma 10.1
30 cytomegalovirus infection 10.1
31 mesenteric lymphadenitis 10.0 IL6 MYD88
32 mesangial proliferative glomerulonephritis 10.0 AXL IL6
33 monoclonal gammopathy of uncertain significance 10.0 IL6 MYD88
34 paracoccidioidomycosis 9.9 IL6 MYD88
35 multiple sclerosis 9.9
36 keratitis, hereditary 9.9
37 anemia, autoimmune hemolytic 9.9
38 aplastic anemia 9.9
39 protein z deficiency 9.9
40 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 9.9
41 lymphatic malformation 7 9.9
42 lymphoproliferative syndrome 3 9.9
43 diabetes mellitus 9.9
44 hemolytic anemia 9.9
45 malignant glioma 9.9
46 epidemic typhus 9.9
47 endemic typhus 9.9
48 trypanosomiasis 9.9
49 louping ill 9.9
50 viral meningitis 9.9

Graphical network of the top 20 diseases related to Lymphocytic Choriomeningitis:



Diseases related to Lymphocytic Choriomeningitis

Symptoms & Phenotypes for Lymphocytic Choriomeningitis

GenomeRNAi Phenotypes related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-1 9.77 LAMC3 NOP56 NRL PIWIL3 PPP1R15B SLC46A1
2 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-2 9.77 LAMC3 NOP56 NRL PIWIL3 PPP1R15B SLC46A1
3 Decreased lymphocytic choriomeningitis virus (LCMV) infection GR00241-A-3 9.5 LAMC3 NOP56 NRL PIWIL3 PPP1R15B SLC46A1
4 Decreased human parainfluenza virus type 3 (HPIV3) infection GR00241-A-4 9.16 NOP56 PPP1R15B

MGI Mouse Phenotypes related to Lymphocytic Choriomeningitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.61 AXL CLEC4G DAG1 DDX3X IL6 MYD88
2 vision/eye MP:0005391 9.1 AXL DAG1 IL6 LAMC3 MYD88 NRL

Drugs & Therapeutics for Lymphocytic Choriomeningitis

Drugs for Lymphocytic Choriomeningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2,Phase 1
2 Immunologic Factors Phase 2
3 Antiviral Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study of CMV Vaccine (HB-101) in Kidney Transplant Patients Recruiting NCT03629080 Phase 2
2 Trial to Evaluate Safety and Immunogenicity of a Vaccine Against HCMV Completed NCT02798692 Phase 1

Search NIH Clinical Center for Lymphocytic Choriomeningitis

Cochrane evidence based reviews: lymphocytic choriomeningitis

Genetic Tests for Lymphocytic Choriomeningitis

Anatomical Context for Lymphocytic Choriomeningitis

MalaCards organs/tissues related to Lymphocytic Choriomeningitis:

42
T Cells, Brain, Spleen, B Cells, Kidney, Liver, Testes

Publications for Lymphocytic Choriomeningitis

Articles related to Lymphocytic Choriomeningitis:

(show top 50) (show all 1138)
# Title Authors Year
1
Immune Exhaustion: Past Lessons and New Insights from Lymphocytic Choriomeningitis Virus. ( 30781904 )
2019
2
Lymphocytic Choriomeningitis Virus Infection Demonstrates Higher Replicative Capacity and Decreased Antiviral Response in the First-Trimester Placenta. ( 30882005 )
2019
3
Metabolic Reprogramming by the Excessive AMPK Activation Exacerbates Antigen-Specific Memory CD8+ T Cell Differentiation after Acute Lymphocytic Choriomeningitis Virus Infection. ( 31089438 )
2019
4
Improved Method of RNA Isolation from Laser Capture Microdissection (LCM)-Derived Plant Tissues. ( 30945180 )
2019
5
Improved laser capture microdissection (LCM)-based method for isolation of RNA, including miRNA and expression analysis in woody apple bud meristem. ( 30976910 )
2019
6
Congenital Lymphocytic Choriomeningitis Virus: A Case of Prenatal Diagnosis. ( 28858375 )
2018
7
Seroprevalence of lymphocytic choriomeningitis virus and Ljungan virus in Finnish patients with suspected neurological infections. ( 28976562 )
2018
8
Osteoblasts Are Rapidly Ablated by Virus-Induced Systemic Inflammation following Lymphocytic Choriomeningitis Virus or Pneumonia Virus of Mice Infection in Mice. ( 29212906 )
2018
9
Congenital lymphocytic choriomeningitis virus-an underdiagnosed fetal teratogen. ( 29274373 )
2018
10
Inhibition of the Fibrinogen-Like Protein 2:FcγRIIB/RIII immunosuppressive pathway enhances antiviral T-cell and B-cell responses leading to clearance of lymphocytic choriomeningitis virus clone 13. ( 29341118 )
2018
11
Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na+/K+ transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenaviruses. ( 29462184 )
2018
12
Adenovirus Vector Vaccination Impacts NK Cell Rheostat Function following Lymphocytic Choriomeningitis Virus Infection. ( 29514912 )
2018
13
Hypoxic marker CA IX and adhesion mediator β-catenin are downregulated by lymphocytic choriomeningitis virus persistent infection. ( 29560117 )
2018
14
Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection. ( 29593047 )
2018
15
Lymphocytic choriomeningitis virus infection of dendritic cells interferes with TLR-induced IL-12/IL-23 cytokine production in an IL-10 independent manner. ( 29602153 )
2018
16
Dynamics of Lymphocyte Reconstitution After Hematopoietic Transplantation During Chronic Lymphocytic Choriomeningitis Virus Infection. ( 29620933 )
2018
17
Replication-incompetent rabies virus vector harboring glycoprotein gene of lymphocytic choriomeningitis virus (LCMV) protects mice from LCMV challenge. ( 29659579 )
2018
18
Effective Treatment of Experimental Lymphocytic Choriomeningitis Virus Infection: Consideration of Favipiravir for Use With Infected Organ Transplant Recipients. ( 29762684 )
2018
19
Crystal structures of Lymphocytic choriomeningitis virus endonuclease domain complexed with diketo-acid ligands. ( 29765612 )
2018
20
Isolation and genomic characterization of lymphocytic choriomeningitis virus in ticks from northeastern China. ( 29992783 )
2018
21
Lymphocytic choriomeningitis virus Clone 13 infection causes either persistence or acute death dependent on IFN-1, cytotoxic T lymphocytes (CTLs), and host genetics. ( 30061383 )
2018
22
Lymphocytic choriomeningitis virus meningoencephalitis in a renal transplant recipient following exposure to mice. ( 30325104 )
2018
23
Cell-to-cell transmission of lymphocytic choriomeningitis virus MX strain during persistent infection and its influence on cell migration. ( 30472873 )
2018
24
Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain. ( 30557576 )
2018
25
CD47 Expression in Natural Killer Cells Regulates Homeostasis and Modulates Immune Response to Lymphocytic Choriomeningitis Virus. ( 30643501 )
2018
26
Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry (LCM-LC/MS). ( 29733325 )
2018
27
Intravenous lacosamide (LCM) in status epilepticus (SE): Weight-adjusted dose and efficacy. ( 29758445 )
2018
28
LCM-Seq: A Method for Spatial Transcriptomic Profiling Using Laser Capture Microdissection Coupled with PolyA-Based RNA Sequencing. ( 29130192 )
2018
29
Characterization and mechanism analysis of lincomycin biodegradation with Clostridium sp. strain LCM-B isolated from lincomycin mycelial residue (LMR). ( 29169137 )
2018
30
LCM-seq reveals the crucial role of LsSOC1 in heat-promoted bolting of lettuce (Lactuca sativa L.). ( 29772090 )
2018
31
Screening diagnostic biomarkers of OSCC via an LCM-based proteomic approach. ( 30066921 )
2018
32
Additive Protection against Congenital Cytomegalovirus Conferred by Combined Glycoprotein B/pp65 Vaccination Using a Lymphocytic Choriomeningitis Virus Vector. ( 27795301 )
2017
33
Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens. ( 27899229 )
2017
34
Farnesoid X Receptor in Mice Prevents Severe Liver Immunopathology During Lymphocytic Choriomeningitis Virus Infection. ( 28214859 )
2017
35
High clinical suspicion of donor-derived disease leads to timely recognition and early intervention to treat solid organ transplant-transmitted lymphocytic choriomeningitis virus. ( 28423464 )
2017
36
Extrinsic Protein Tyrosine Phosphatase Non-Receptor 22 Signals Contribute to CD8 T Cell Exhaustion and Promote Persistence of Chronic Lymphocytic Choriomeningitis Virus Infection. ( 28747914 )
2017
37
Microcephaly Caused by Lymphocytic Choriomeningitis Virus. ( 28820372 )
2017
38
Resistance of human plasmacytoid dendritic CAL-1 cells to infection with lymphocytic choriomeningitis virus (LCMV) is caused by restricted virus cell entry, which is overcome by contact of CAL-1 cells with LCMV-infected cells. ( 28843812 )
2017
39
IRF9 Prevents CD8+ T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection. ( 28878077 )
2017
40
Visualization of the lymphocytic choriomeningitis mammarenavirus (LCMV) genome reveals the early endosome as a possible site for genome replication and viral particle pre-assembly. ( 28949905 )
2017
41
CD30 Is Dispensable for T-Cell Responses to Influenza Virus and Lymphocytic Choriomeningitis Virus Clone 13 but Contributes to Age-Associated T-Cell Expansion in Mice. ( 28993768 )
2017
42
Semi-Functional Quantitative Flow Cytometry Assay for Lymphocytic Choriomeningitis Virus Titration. ( 29093652 )
2017
43
Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein. ( 29261807 )
2017
44
Clinical outcomes linked to expression of gene subsets for protein hormones and their cognate receptors from LCM-procured breast carcinoma cells. ( 27858316 )
2017
45
Permanent Draft Genome Sequence of Ensifer sp. Strain LCM 4579, a Salt-Tolerant, Nitrogen-Fixing Bacterium Isolated from Senegalese Soil. ( 28385842 )
2017
46
Permanent Draft Genome Sequence of Rhizobium sp. Strain LCM 4573, a Salt-Tolerant, Nitrogen-Fixing Bacterium Isolated from Senegalese Soils. ( 28473386 )
2017
47
Human Papillomavirus (HPV) Genotypes in Condylomas, Intraepithelial Neoplasia, and Invasive Carcinoma of the Penis Using Laser Capture Microdissection (LCM)-PCR: A Study of 191 Lesions in 43 Patients. ( 28486384 )
2017
48
Permanent Draft Genome Sequences for Mesorhizobium sp. Strains LCM 4576, LCM 4577, and ORS3428, Salt-Tolerant, Nitrogen-Fixing Bacteria Isolated from Senegalese Soils. ( 29025952 )
2017
49
Lymphocytic choriomeningitis virus infection induced by percutaneous exposure. ( 26416845 )
2016
50
Identification of lymphocytic choriomeningitis mammarenavirus in house mouse (Mus musculus, Rodentia) in French Guiana. ( 26631809 )
2016

Variations for Lymphocytic Choriomeningitis

Expression for Lymphocytic Choriomeningitis

Search GEO for disease gene expression data for Lymphocytic Choriomeningitis.

Pathways for Lymphocytic Choriomeningitis

Pathways related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.85 IL6 MYD88
2 10.52 IL6 MYD88
3 10.11 IL6 SLC46A1

GO Terms for Lymphocytic Choriomeningitis

Biological processes related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.62 AXL DDX3X IL6 MYD88
2 viral process GO:0016032 9.56 AXL CLEC4G DAG1 DDX3X
3 regulation of translation GO:0006417 9.33 DDX3X PIWIL3 PPP1R15B
4 viral entry into host cell GO:0046718 9.13 AXL CLEC4G DAG1
5 response to peptidoglycan GO:0032494 8.62 IL6 MYD88

Molecular functions related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.8 AXL CLEC4G DAG1

Sources for Lymphocytic Choriomeningitis

3 CDC
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9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
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31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
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45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
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55 NINDS
56 Novoseek
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59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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