MCID: LYM009
MIFTS: 50

Lymphocytic Choriomeningitis

Categories: Infectious diseases, Immune diseases

Aliases & Classifications for Lymphocytic Choriomeningitis

MalaCards integrated aliases for Lymphocytic Choriomeningitis:

Name: Lymphocytic Choriomeningitis 12 55 3 44 15 73
Lcm 12 3
Lymphocytic Choriomeningitis Virus Encephalomyelitis 12
Non-Arthropod Borne Lymphocytic Choriomeningitis 73
Lymphocytic Meningoencephalitis 12
Lymphocytic Meningitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12155
ICD10 33 A87.2
ICD9CM 35 049.0
MeSH 44 D008216

Summaries for Lymphocytic Choriomeningitis

Disease Ontology : 12 A viral infectious disease that results in infection located in brain, or located in meninges, or located in brain and meninges, has material basis in Lymphocytic choriomeningitis virus, which is transmitted by common house mouse, Mus musculus. The infection has symptom fever, has symptom lack of appetite, has symptom headache, has symptom muscle aches, has symptom malaise, has symptom nausea, and has symptom vomiting.

MalaCards based summary : Lymphocytic Choriomeningitis, also known as lcm, is related to lassa fever and mollaret meningitis, and has symptoms including fever, lack of appetite and headache. An important gene associated with Lymphocytic Choriomeningitis is DAG1 (Dystroglycan 1), and among its related pathways/superpathways are Delta508-CFTR traffic / ER-to-Golgi in CF and Arf1 pathway. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include brain, meninges and brain, and related phenotypes are Decreased influenza A virus infection and Decreased influenza A virus infection

CDC : 3 Lymphocytic choriomeningitis, or LCM, is a rodent-borne viral infectious disease caused by lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae, that was initially isolated in 1933.

Wikipedia : 76 Lymphocytic choriomeningitis (LCM) is a rodent-borne viral infectious disease that presents as aseptic... more...

Related Diseases for Lymphocytic Choriomeningitis

Diseases related to Lymphocytic Choriomeningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 lassa fever 30.2 AXL DAG1
2 mollaret meningitis 11.8
3 meningitis 10.2
4 type i 10.2
5 hepatitis 10.1
6 central nervous system disease 10.1
7 nervous system disease 10.1
8 neuronitis 10.1
9 influenza 10.1
10 growth hormone deficiency 10.1
11 la crosse encephalitis 10.1 AXL TYRO3
12 cerebellar hypoplasia 10.0
13 aging 10.0
14 chorioretinitis 10.0
15 hydrocephalus 10.0
16 meningoencephalitis 10.0
17 stomatitis 10.0
18 leukemia 9.9
19 mucositis 9.9
20 mumps 9.9
21 parotitis 9.9
22 orchitis 9.9
23 vaccinia 9.9
24 encephalitis 9.9
25 toxoplasmosis 9.9
26 glioma 9.9
27 hemorrhagic fever 9.9
28 cytomegalovirus infection 9.9
29 multiple sclerosis 9.7
30 anemia, autoimmune hemolytic 9.7
31 aplastic anemia 9.7
32 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 9.7
33 hydrops fetalis, nonimmune, and/or atrial septal defect 9.7
34 diabetes mellitus 9.7
35 hemolytic anemia 9.7
36 malignant glioma 9.7
37 trypanosomiasis 9.7
38 louping ill 9.7
39 viral meningitis 9.7
40 microcephaly 9.7
41 q fever 9.7
42 rickettsialpox 9.7
43 pertussis 9.7
44 rabies 9.7
45 choroiditis 9.7
46 aseptic meningitis 9.7
47 congenital toxoplasmosis 9.7
48 lymphogranuloma venereum 9.7
49 histoplasmosis 9.7
50 b cell deficiency 9.7

Graphical network of the top 20 diseases related to Lymphocytic Choriomeningitis:



Diseases related to Lymphocytic Choriomeningitis

Symptoms & Phenotypes for Lymphocytic Choriomeningitis

Symptoms:

12
  • fever
  • lack of appetite
  • headache
  • muscle aches
  • malaise
  • nausea
  • vomiting

GenomeRNAi Phenotypes related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

26 (show all 40)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased influenza A virus infection GR00147-A-1 10.15 ARCN1 COPA ATP6V0B
2 Decreased influenza A virus infection GR00147-A-2 10.15 ARCN1 COPA ATP6V0B
3 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.01 DDX3X
4 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.01 CARD14
5 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.01 ARF1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.01 CARD14
7 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.01 ARF1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.01 CARD14
9 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.01 ARF1 ARCN1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.01 ARCN1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.01 CARD14
12 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.01 COPA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.01 COPA ARF1 CARD14
14 Increased shRNA abundance (Z-score > 2) GR00366-A-166 10.01 ARF1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10.01 ARCN1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.01 COPA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-194 10.01 DDX3X
18 Increased shRNA abundance (Z-score > 2) GR00366-A-196 10.01 ARCN1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.01 CARD14 ARCN1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-199 10.01 DDX3X ARCN1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.01 DDX3X
22 Increased shRNA abundance (Z-score > 2) GR00366-A-207 10.01 DDX3X CARD14
23 Increased shRNA abundance (Z-score > 2) GR00366-A-208 10.01 DDX3X
24 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.01 ARCN1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.01 ARF1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.01 DDX3X
27 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.01 DDX3X CARD14
28 Increased shRNA abundance (Z-score > 2) GR00366-A-54 10.01 DDX3X
29 Increased shRNA abundance (Z-score > 2) GR00366-A-56 10.01 ARCN1
30 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.01 ARF1
31 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.01 CARD14
32 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.01 DDX3X
33 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10.01 DDX3X
34 Increased shRNA abundance (Z-score > 2) GR00366-A-92 10.01 ARF1 DDX3X ARCN1
35 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-1 9.98 ATP6AP2 COPA ATP6V0B CARD14 ARCN1
36 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-2 9.98 COPA ATP6AP2 ATP6V0B ARF1 CARD14 ARCN1
37 Decreased lymphocytic choriomeningitis virus (LCMV) infection GR00241-A-3 9.8 ATP6V0B ARF1 CARD14 ARCN1 ATP6AP2 COPA
38 Decreased Salmonella-containing vacuole maturation GR00133-A-2 9.46 ATP6AP2 COPA ARCN1 TYRO3
39 Decreased Salmonella enterica Typhimurium binding GR00133-A-3 9.43 COPA ARF1 ARCN1
40 Decreased human parainfluenza virus type 3 (HPIV3) infection GR00241-A-4 9.4 ARCN1 COPA

Drugs & Therapeutics for Lymphocytic Choriomeningitis

Drugs for Lymphocytic Choriomeningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trial to Evaluate Safety and Immunogenicity of a Vaccine Against HCMV Completed NCT02798692 Phase 1

Search NIH Clinical Center for Lymphocytic Choriomeningitis

Cochrane evidence based reviews: lymphocytic choriomeningitis

Genetic Tests for Lymphocytic Choriomeningitis

Anatomical Context for Lymphocytic Choriomeningitis

The Foundational Model of Anatomy Ontology organs/tissues related to Lymphocytic Choriomeningitis:

19
Brain, Meninges, Brain

MalaCards organs/tissues related to Lymphocytic Choriomeningitis:

41
T Cells, Brain, Spleen, B Cells, Liver, Nk Cells, Monocytes

Publications for Lymphocytic Choriomeningitis

Articles related to Lymphocytic Choriomeningitis:

(show top 50) (show all 573)
# Title Authors Year
1
Dynamics of Lymphocyte Reconstitution After Hematopoietic Transplantation During Chronic Lymphocytic Choriomeningitis Virus Infection. ( 29620933 )
2018
2
Inhibition of the Fibrinogen-Like Protein 2:FcI^RIIB/RIII immunosuppressive pathway enhances antiviral T-cell and B-cell responses leading to clearance of lymphocytic choriomeningitis virus clone 13. ( 29341118 )
2018
3
Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection. ( 29593047 )
2018
4
Osteoblasts Are Rapidly Ablated by Virus-Induced Systemic Inflammation following Lymphocytic Choriomeningitis Virus or Pneumonia Virus of Mice Infection in Mice. ( 29212906 )
2018
5
Hypoxic marker CA IX and adhesion mediator I^-catenin are downregulated by lymphocytic choriomeningitis virus persistent infection. ( 29560117 )
2018
6
Replication-incompetent rabies virus vector harboring glycoprotein gene of lymphocytic choriomeningitis virus (LCMV) protects mice from LCMV challenge. ( 29659579 )
2018
7
Lymphocytic choriomeningitis virus infection of dendritic cells interferes with TLR-induced IL-12/IL-23 cytokine production in an IL-10 independent manner. ( 29602153 )
2018
8
Crystal structures of <i>Lymphocytic choriomeningitis virus</i> endonuclease domain complexed with diketo-acid ligands. ( 29765612 )
2018
9
Effective Treatment of Experimental Lymphocytic Choriomeningitis Virus Infection: Consideration of Favipiravir for use with Infected Organ Transplant Recipients. ( 29762684 )
2018
10
Seroprevalence of lymphocytic choriomeningitis virus and Ljungan virus in Finnish patients with suspected neurological infections. ( 28976562 )
2018
11
Adenovirus Vector Vaccination Impacts NK Cell Rheostat Function following Lymphocytic Choriomeningitis Virus Infection. ( 29514912 )
2018
12
Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na+/K+ transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenaviruses. ( 29462184 )
2018
13
IRF9 Prevents CD8<sup>+</sup>T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection. ( 28878077 )
2017
14
Resistance of human plasmacytoid dendritic CAL-1 cells to infection with lymphocytic choriomeningitis virus (LCMV) is caused by restricted virus cell entry, which is overcome by contact of CAL-1 cells with LCMV-infected cells. ( 28843812 )
2017
15
Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein. ( 29261807 )
2017
16
Visualization of the lymphocytic choriomeningitis mammarenavirus (LCMV) genome reveals the early endosome as a possible site for genome replication and viral particle pre-assembly. ( 28949905 )
2017
17
Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens. ( 27899229 )
2017
18
Additive Protection against Congenital Cytomegalovirus Conferred by Combined Glycoprotein B/pp65 Vaccination Using a Lymphocytic Choriomeningitis Virus Vector. ( 27795301 )
2017
19
Microcephaly Caused by Lymphocytic Choriomeningitis Virus. ( 28820372 )
2017
20
Semi-Functional Quantitative Flow Cytometry Assay for Lymphocytic Choriomeningitis Virus Titration. ( 29093652 )
2017
21
Congenital Lymphocytic Choriomeningitis Virus: A Case of Prenatal Diagnosis. ( 28858375 )
2017
22
Congenital lymphocytic choriomeningitis virus-an underdiagnosed fetal teratogen. ( 29274373 )
2017
23
Extrinsic Protein Tyrosine Phosphatase Non-Receptor 22 Signals Contribute to CD8 T Cell Exhaustion and Promote Persistence of Chronic Lymphocytic Choriomeningitis Virus Infection. ( 28747914 )
2017
24
CD30 Is Dispensable for T-Cell Responses to Influenza Virus and Lymphocytic Choriomeningitis Virus Clone 13 but Contributes to Age-Associated T-Cell Expansion in Mice. ( 28993768 )
2017
25
Farnesoid X Receptor in Mice Prevents Severe Liver Immunopathology During Lymphocytic Choriomeningitis Virus Infection. ( 28214859 )
2017
26
High clinical suspicion of donor-derived disease leads to timely recognition and early intervention to treat solid organ transplant-transmitted lymphocytic choriomeningitis virus. ( 28423464 )
2017
27
Lymphocytic choriomeningitis, Ljungan and orthopoxvirus seroconversions in patients hospitalized due to acute Puumala hantavirus infection. ( 27721109 )
2016
28
Generation of Lymphocytic Choriomeningitis Virus Based Vaccine Vectors. ( 27076310 )
2016
29
Identification of lymphocytic choriomeningitis mammarenavirus in house mouse (Mus musculus, Rodentia) in French Guiana. ( 26631809 )
2016
30
Residues K465 and G467 within the Cytoplasmic Domain of GP2 Play a Critical Role in the Persistence of Lymphocytic Choriomeningitis Virus in Mice. ( 27581982 )
2016
31
T-Cells Underlie Some but Not All of the Cerebellar Pathology in a Neonatal Rat Model of Congenital Lymphocytic Choriomeningitis Virus Infection. ( 27667772 )
2016
32
Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice. ( 27404802 )
2016
33
Notes from the Field: Lymphocytic Choriomeningitis Virus Meningoencephalitis from a Household Rodent Infestation - Minnesota, 2015. ( 26963688 )
2016
34
Lymphocytic choriomeningitis virus: ways to establish and maintain non-cytolytic persistent infection. ( 26982463 )
2016
35
Replication-defective lymphocytic choriomeningitis virus vectors expressing guinea pig cytomegalovirus gB and pp65 homologs are protective against congenital guinea pig cytomegalovirus infection. ( 26973071 )
2016
36
Dendritic Cells Are Dispensable for T Cell Priming and Control of Acute Lymphocytic Choriomeningitis Virus Infection. ( 27549169 )
2016
37
The Lymphocytic Choriomeningitis Virus Matrix Protein PPXY Late Domain Drives the Production of Defective Interfering Particles. ( 27010636 )
2016
38
Development and application of ELISA for the detection of IgG antibodies to lymphocytic choriomeningitis virus. ( 27265463 )
2016
39
Differential Inhibition of Macrophage Activation by Lymphocytic Choriomeningitis Virus and Pichinde Virus Is Mediated by the Z Protein N-Terminal Domain. ( 26423945 )
2015
40
Lymphocytic Choriomeningitis Virus Expands a Population of NKG2D+CD8+ T Cells That Exacerbates Disease in Mice Coinfected with Leishmania major. ( 26290604 )
2015
41
Peptide motif analysis predicts lymphocytic choriomeningitis virus as trigger for multiple sclerosis. ( 26319106 )
2015
42
Lymphocytic choriomeningitis virus infection induced by percutaneous exposure. ( 26416845 )
2015
43
Maternal onset de novo SH2D1A mutation and lymphocytic choriomeningitis virus infection in a patient with Xa89linked lymphoproliferative disease type 1: a case report. ( 25572984 )
2015
44
Lymphocytic choriomeningitis virus differentially affects virus-induced type I IFN response and mitochondrial apoptosis mediated by RIG-I/MAVS. ( 25833049 )
2015
45
The Nucleoprotein Is Required for Lymphocytic Choriomeningitis Virus-Based Vaccine Vector Immunogenicity. ( 26355095 )
2015
46
Antiviral Effect of Interferon Lambda Against Lymphocytic Choriomeningitis Virus. ( 25830339 )
2015
47
Lymphocytic choriomeningitis and alpha-chemokines. ( 26152632 )
2015
48
Evolution of recombinant lymphocytic choriomeningitis virus/Lassa virus in vivo highlights the importance of the GPC cytosolic tail in viral fitness. ( 24829355 )
2014
49
Notes from the field: a cluster of lymphocytic choriomeningitis virus infections transmitted through organ transplantation - Iowa, 2013. ( 24647402 )
2014
50
Anti-GITR Agonist Therapy Intrinsically Enhances CD8 T Cell Responses to Chronic Lymphocytic Choriomeningitis Virus (LCMV), Thereby Circumventing LCMV-Induced Downregulation of Costimulatory GITR Ligand on APC. ( 25281716 )
2014

Variations for Lymphocytic Choriomeningitis

Expression for Lymphocytic Choriomeningitis

Search GEO for disease gene expression data for Lymphocytic Choriomeningitis.

Pathways for Lymphocytic Choriomeningitis

GO Terms for Lymphocytic Choriomeningitis

Cellular components related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 COPI vesicle coat GO:0030126 8.96 ARCN1 COPA
2 COPI-coated vesicle membrane GO:0030663 8.62 ARCN1 COPA

Biological processes related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.72 AXL CARD14 DDX3X MYD88 TYRO3
2 viral process GO:0016032 9.65 AXL CLEC4G DAG1 DDX3X TYRO3
3 protein kinase B signaling GO:0043491 9.51 AXL TYRO3
4 substrate adhesion-dependent cell spreading GO:0034446 9.49 AXL TYRO3
5 apoptotic cell clearance GO:0043277 9.48 AXL TYRO3
6 vagina development GO:0060068 9.46 AXL TYRO3
7 ovulation cycle GO:0042698 9.43 AXL TYRO3
8 natural killer cell differentiation GO:0001779 9.4 AXL TYRO3
9 secretion by cell GO:0032940 9.37 AXL TYRO3
10 forebrain cell migration GO:0021885 9.16 AXL TYRO3
11 negative regulation of lymphocyte activation GO:0051250 8.96 AXL TYRO3
12 viral entry into host cell GO:0046718 8.92 AXL CLEC4G DAG1 TYRO3

Molecular functions related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol 3-kinase binding GO:0043548 8.96 AXL TYRO3
2 virus receptor activity GO:0001618 8.92 AXL CLEC4G DAG1 TYRO3

Sources for Lymphocytic Choriomeningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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