LCM
MCID: LYM009
MIFTS: 46

Lymphocytic Choriomeningitis (LCM)

Categories: Genetic diseases, Immune diseases, Infectious diseases, Neuronal diseases

Aliases & Classifications for Lymphocytic Choriomeningitis

MalaCards integrated aliases for Lymphocytic Choriomeningitis:

Name: Lymphocytic Choriomeningitis 12 55 3 44 15 73
Lcm 12 3
Lymphocytic Choriomeningitis Virus Encephalomyelitis 12
Non-Arthropod Borne Lymphocytic Choriomeningitis 73
Lymphocytic Meningoencephalitis 12
Lymphocytic Meningitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12155
ICD10 33 A87.2
MeSH 44 D008216
SNOMED-CT 68 38666007

Summaries for Lymphocytic Choriomeningitis

Disease Ontology : 12 A viral infectious disease that results in infection located in brain, or located in meninges, or located in brain and meninges, has material basis in Lymphocytic choriomeningitis virus, which is transmitted by common house mouse, Mus musculus. The infection has symptom fever, has symptom lack of appetite, has symptom headache, has symptom muscle aches, has symptom malaise, has symptom nausea, and has symptom vomiting.

MalaCards based summary : Lymphocytic Choriomeningitis, also known as lcm, is related to lassa fever and mollaret meningitis. An important gene associated with Lymphocytic Choriomeningitis is DAG1 (Dystroglycan 1), and among its related pathways/superpathways are African trypanosomiasis and Antifolate resistance. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spleen, and related phenotypes are Decreased vesicular stomatitis virus (VSV) infection and Decreased vesicular stomatitis virus (VSV) infection

CDC : 3 Lymphocytic choriomeningitis, or LCM, is a rodent-borne viral infectious disease caused by lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae, that was initially isolated in 1933.

Wikipedia : 76 Lymphocytic choriomeningitis (LCM) is a rodent-borne viral infectious disease that presents as aseptic... more...

Related Diseases for Lymphocytic Choriomeningitis

Diseases related to Lymphocytic Choriomeningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 lassa fever 30.3 AXL DAG1
2 mollaret meningitis 11.9
3 mantle cell lymphoma 11.4
4 viral infectious disease 11.0
5 meningitis 10.4
6 hepatitis 10.3
7 hydrocephalus 10.3
8 rabies 10.3
9 central nervous system disease 10.3
10 influenza 10.3
11 nervous system disease 10.3
12 growth hormone deficiency 10.3
13 glomerulonephritis 10.2
14 leukemia 10.2
15 meningoencephalitis 10.2
16 pertussis 10.2
17 vaccinia 10.2
18 encephalitis 10.2
19 cerebellar hypoplasia 10.2
20 chorioretinitis 10.2
21 stomatitis 10.2
22 la crosse encephalitis 10.1 AXL TYRO3
23 mumps 10.1
24 aseptic meningitis 10.1
25 parainfluenza virus type 3 10.1 SLC9A3 UTP6
26 lymphoma 10.0
27 parotitis 10.0
28 orchitis 10.0
29 retinitis 10.0
30 herpes simplex 10.0
31 toxoplasmosis 10.0
32 glioma 10.0
33 hemorrhagic fever 10.0
34 cytomegalovirus infection 10.0
35 mesenteric lymphadenitis 10.0 IL6 MYD88
36 mesangial proliferative glomerulonephritis 10.0 AXL IL6
37 monoclonal gammopathy of uncertain significance 10.0 IL6 MYD88
38 paracoccidioidomycosis 9.9 IL6 MYD88
39 multiple sclerosis 9.9
40 anemia, autoimmune hemolytic 9.9
41 neuroblastoma 9.9
42 aplastic anemia 9.9
43 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 9.9
44 hydrops fetalis, nonimmune, and/or atrial septal defect 9.9
45 diabetes mellitus 9.9
46 hemolytic anemia 9.9
47 malignant glioma 9.9
48 trypanosomiasis 9.9
49 louping ill 9.9
50 viral meningitis 9.9

Graphical network of the top 20 diseases related to Lymphocytic Choriomeningitis:



Diseases related to Lymphocytic Choriomeningitis

Symptoms & Phenotypes for Lymphocytic Choriomeningitis

GenomeRNAi Phenotypes related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-1 9.7 HNRNPK SLC46A1 SLC9A3 SYVN1 TAS2R19 UTP6
2 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-2 9.7 HNRNPK SLC46A1 SLC9A3 SYVN1 TAS2R19 UTP6
3 Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection GR00233-A-1 9.46 DDX3X HNRNPK SYVN1 UTP6
4 Decreased lymphocytic choriomeningitis virus (LCMV) infection GR00241-A-3 9.43 HNRNPK SLC46A1 SLC9A3 SYVN1 TAS2R19 UTP6
5 Decreased human parainfluenza virus type 3 (HPIV3) infection GR00241-A-4 9.26 SLC9A3 UTP6

MGI Mouse Phenotypes related to Lymphocytic Choriomeningitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.5 AXL DAG1 DDX3X IL6 MYD88 SLC9A3
2 homeostasis/metabolism MP:0005376 9.28 AXL CLEC4G DAG1 DDX3X IL6 MYD88

Drugs & Therapeutics for Lymphocytic Choriomeningitis

Drugs for Lymphocytic Choriomeningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2,Phase 1
2 Immunologic Factors Phase 2
3 Antiviral Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study of CMV Vaccine (HB-101) in Kidney Transplant Patients Recruiting NCT03629080 Phase 2
2 Trial to Evaluate Safety and Immunogenicity of a Vaccine Against HCMV Completed NCT02798692 Phase 1

Search NIH Clinical Center for Lymphocytic Choriomeningitis

Cochrane evidence based reviews: lymphocytic choriomeningitis

Genetic Tests for Lymphocytic Choriomeningitis

Anatomical Context for Lymphocytic Choriomeningitis

MalaCards organs/tissues related to Lymphocytic Choriomeningitis:

41
T Cells, Brain, Spleen, Kidney, Bone, B Cells, Bone Marrow

Publications for Lymphocytic Choriomeningitis

Articles related to Lymphocytic Choriomeningitis:

(show top 50) (show all 1104)
# Title Authors Year
1
Dynamics of Lymphocyte Reconstitution After Hematopoietic Transplantation During Chronic Lymphocytic Choriomeningitis Virus Infection. ( 29620933 )
2018
2
Inhibition of the Fibrinogen-Like Protein 2:FcI^RIIB/RIII immunosuppressive pathway enhances antiviral T-cell and B-cell responses leading to clearance of lymphocytic choriomeningitis virus clone 13. ( 29341118 )
2018
3
Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection. ( 29593047 )
2018
4
Osteoblasts Are Rapidly Ablated by Virus-Induced Systemic Inflammation following Lymphocytic Choriomeningitis Virus or Pneumonia Virus of Mice Infection in Mice. ( 29212906 )
2018
5
Hypoxic marker CA IX and adhesion mediator I^-catenin are downregulated by lymphocytic choriomeningitis virus persistent infection. ( 29560117 )
2018
6
Replication-incompetent rabies virus vector harboring glycoprotein gene of lymphocytic choriomeningitis virus (LCMV) protects mice from LCMV challenge. ( 29659579 )
2018
7
Lymphocytic choriomeningitis virus infection of dendritic cells interferes with TLR-induced IL-12/IL-23 cytokine production in an IL-10 independent manner. ( 29602153 )
2018
8
Crystal structures of <i>Lymphocytic choriomeningitis virus</i> endonuclease domain complexed with diketo-acid ligands. ( 29765612 )
2018
9
Effective Treatment of Experimental Lymphocytic Choriomeningitis Virus Infection: Consideration of Favipiravir for use with Infected Organ Transplant Recipients. ( 29762684 )
2018
10
Seroprevalence of lymphocytic choriomeningitis virus and Ljungan virus in Finnish patients with suspected neurological infections. ( 28976562 )
2018
11
Adenovirus Vector Vaccination Impacts NK Cell Rheostat Function following Lymphocytic Choriomeningitis Virus Infection. ( 29514912 )
2018
12
Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na+/K+ transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenaviruses. ( 29462184 )
2018
13
Isolation and genomic characterization of lymphocytic choriomeningitis virus in ticks from northeastern China. ( 29992783 )
2018
14
Lymphocytic choriomeningitis virus Clone 13 infection causes either persistence or acute death dependent on IFN-1, cytotoxic T lymphocytes (CTLs), and host genetics. ( 30061383 )
2018
15
Lymphocytic choriomeningitis virus meningoencephalitis in a renal transplant recipient following exposure to mice. ( 30325104 )
2018
16
Cell-to-cell transmission of lymphocytic choriomeningitis virus MX strain during persistent infection and its influence on cell migration. ( 30472873 )
2018
17
Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain. ( 30557576 )
2018
18
Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry (LCM-LC/MS). ( 29733325 )
2018
19
Intravenous lacosamide (LCM) in status epilepticus (SE): Weight-adjusted dose and efficacy. ( 29758445 )
2018
20
LCM-Seq: A Method for Spatial Transcriptomic Profiling Using Laser Capture Microdissection Coupled with PolyA-Based RNA Sequencing. ( 29130192 )
2018
21
Characterization and mechanism analysis of lincomycin biodegradation with Clostridium sp. strain LCM-B isolated from lincomycin mycelial residue (LMR). ( 29169137 )
2018
22
LCM-seq reveals the crucial role of LsSOC1 in heat-promoted bolting of lettuce (Lactuca sativa L.). ( 29772090 )
2018
23
Screening diagnostic biomarkers of OSCC via an LCM-based proteomic approach. ( 30066921 )
2018
24
IRF9 Prevents CD8<sup>+</sup>T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection. ( 28878077 )
2017
25
Resistance of human plasmacytoid dendritic CAL-1 cells to infection with lymphocytic choriomeningitis virus (LCMV) is caused by restricted virus cell entry, which is overcome by contact of CAL-1 cells with LCMV-infected cells. ( 28843812 )
2017
26
Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein. ( 29261807 )
2017
27
Visualization of the lymphocytic choriomeningitis mammarenavirus (LCMV) genome reveals the early endosome as a possible site for genome replication and viral particle pre-assembly. ( 28949905 )
2017
28
Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens. ( 27899229 )
2017
29
Additive Protection against Congenital Cytomegalovirus Conferred by Combined Glycoprotein B/pp65 Vaccination Using a Lymphocytic Choriomeningitis Virus Vector. ( 27795301 )
2017
30
Microcephaly Caused by Lymphocytic Choriomeningitis Virus. ( 28820372 )
2017
31
Semi-Functional Quantitative Flow Cytometry Assay for Lymphocytic Choriomeningitis Virus Titration. ( 29093652 )
2017
32
Congenital Lymphocytic Choriomeningitis Virus: A Case of Prenatal Diagnosis. ( 28858375 )
2017
33
Congenital lymphocytic choriomeningitis virus-an underdiagnosed fetal teratogen. ( 29274373 )
2017
34
Extrinsic Protein Tyrosine Phosphatase Non-Receptor 22 Signals Contribute to CD8 T Cell Exhaustion and Promote Persistence of Chronic Lymphocytic Choriomeningitis Virus Infection. ( 28747914 )
2017
35
CD30 Is Dispensable for T-Cell Responses to Influenza Virus and Lymphocytic Choriomeningitis Virus Clone 13 but Contributes to Age-Associated T-Cell Expansion in Mice. ( 28993768 )
2017
36
Farnesoid X Receptor in Mice Prevents Severe Liver Immunopathology During Lymphocytic Choriomeningitis Virus Infection. ( 28214859 )
2017
37
High clinical suspicion of donor-derived disease leads to timely recognition and early intervention to treat solid organ transplant-transmitted lymphocytic choriomeningitis virus. ( 28423464 )
2017
38
Clinical outcomes linked to expression of gene subsets for protein hormones and their cognate receptors from LCM-procured breast carcinoma cells. ( 27858316 )
2017
39
Permanent Draft Genome Sequence of Ensifer sp. Strain LCM 4579, a Salt-Tolerant, Nitrogen-Fixing Bacterium Isolated from Senegalese Soil. ( 28385842 )
2017
40
Permanent Draft Genome Sequence of Rhizobium sp. Strain LCM 4573, a Salt-Tolerant, Nitrogen-Fixing Bacterium Isolated from Senegalese Soils. ( 28473386 )
2017
41
Human Papillomavirus (HPV) Genotypes in Condylomas, Intraepithelial Neoplasia, and Invasive Carcinoma of the Penis Using Laser Capture Microdissection (LCM)-PCR: A Study of 191 Lesions in 43 Patients. ( 28486384 )
2017
42
Permanent Draft Genome Sequences for Mesorhizobium sp. Strains LCM 4576, LCM 4577, and ORS3428, Salt-Tolerant, Nitrogen-Fixing Bacteria Isolated from Senegalese Soils. ( 29025952 )
2017
43
Lymphocytic choriomeningitis, Ljungan and orthopoxvirus seroconversions in patients hospitalized due to acute Puumala hantavirus infection. ( 27721109 )
2016
44
Generation of Lymphocytic Choriomeningitis Virus Based Vaccine Vectors. ( 27076310 )
2016
45
Identification of lymphocytic choriomeningitis mammarenavirus in house mouse (Mus musculus, Rodentia) in French Guiana. ( 26631809 )
2016
46
Residues K465 and G467 within the Cytoplasmic Domain of GP2 Play a Critical Role in the Persistence of Lymphocytic Choriomeningitis Virus in Mice. ( 27581982 )
2016
47
T-Cells Underlie Some but Not All of the Cerebellar Pathology in a Neonatal Rat Model of Congenital Lymphocytic Choriomeningitis Virus Infection. ( 27667772 )
2016
48
Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice. ( 27404802 )
2016
49
Notes from the Field: Lymphocytic Choriomeningitis Virus Meningoencephalitis from a Household Rodent Infestation - Minnesota, 2015. ( 26963688 )
2016
50
Lymphocytic choriomeningitis virus: ways to establish and maintain non-cytolytic persistent infection. ( 26982463 )
2016

Variations for Lymphocytic Choriomeningitis

Expression for Lymphocytic Choriomeningitis

Search GEO for disease gene expression data for Lymphocytic Choriomeningitis.

Pathways for Lymphocytic Choriomeningitis

Pathways related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.5 IL6 MYD88
2 10.11 IL6 SLC46A1

GO Terms for Lymphocytic Choriomeningitis

Cellular components related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.92 AXL SLC46A1 SLC9A3 TYRO3

Biological processes related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 Wnt signaling pathway GO:0016055 9.72 AXL DDX3X TYRO3
2 positive regulation of MAPK cascade GO:0043410 9.7 AXL IL6 TYRO3
3 platelet activation GO:0030168 9.67 AXL IL6 TYRO3
4 negative regulation of apoptotic process GO:0043066 9.63 AXL DDX3X HNRNPK IL6 MYD88 TYRO3
5 substrate adhesion-dependent cell spreading GO:0034446 9.56 AXL TYRO3
6 protein kinase B signaling GO:0043491 9.54 AXL TYRO3
7 apoptotic cell clearance GO:0043277 9.51 AXL TYRO3
8 natural killer cell differentiation GO:0001779 9.48 AXL TYRO3
9 ovulation cycle GO:0042698 9.46 AXL TYRO3
10 secretion by cell GO:0032940 9.43 AXL TYRO3
11 vagina development GO:0060068 9.4 AXL TYRO3
12 response to peptidoglycan GO:0032494 9.37 IL6 MYD88
13 forebrain cell migration GO:0021885 9.32 AXL TYRO3
14 negative regulation of lymphocyte activation GO:0051250 9.26 AXL TYRO3
15 viral entry into host cell GO:0046718 9.26 AXL CLEC4G DAG1 TYRO3
16 viral process GO:0016032 9.1 AXL CLEC4G DAG1 DDX3X HNRNPK TYRO3

Molecular functions related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Wnt-protein binding GO:0017147 9.16 AXL TYRO3
2 phosphatidylinositol 3-kinase binding GO:0043548 8.96 AXL TYRO3
3 virus receptor activity GO:0001618 8.92 AXL CLEC4G DAG1 TYRO3

Sources for Lymphocytic Choriomeningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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