LCM
MCID: LYM009
MIFTS: 46

Lymphocytic Choriomeningitis (LCM)

Categories: Genetic diseases, Immune diseases, Infectious diseases, Muscle diseases, Neuronal diseases

Aliases & Classifications for Lymphocytic Choriomeningitis

MalaCards integrated aliases for Lymphocytic Choriomeningitis:

Name: Lymphocytic Choriomeningitis 12 54 3 44 15 71 32
Lcm 12 3
Lymphocytic Choriomeningitis Virus Encephalomyelitis 12
Non-Arthropod Borne Lymphocytic Choriomeningitis 71
Lymphocytic Meningoencephalitis 12
Lymphocytic Meningitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12155
MeSH 44 D008216
SNOMED-CT 67 192668002
ICD10 32 A87.2
UMLS 71 C0024266 C0153014

Summaries for Lymphocytic Choriomeningitis

CDC : 3 Lymphocytic choriomeningitis, or LCM, is a rodent-borne viral infectious disease caused by lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae, that was initially isolated in 1933. The primary host of LCMV is the common house mouse, Mus musculus. Infection in house mouse populations may vary by geographic location, though it is estimated that 5% of house mice throughout the United States carry LCMV and are able to transmit virus for the duration of their lives without showing any sign of illness. Other types of rodents, such as hamsters, are not the natural reservoirs but can become infected with LCMV from wild mice at the breeder, in the pet store, or home environment. Humans are more likely to contract LCMV from house mice, but infections from pet rodents have also been reported.

MalaCards based summary : Lymphocytic Choriomeningitis, also known as lcm, is related to stomatitis and lassa fever. An important gene associated with Lymphocytic Choriomeningitis is DAG1 (Dystroglycan 1), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Vaccines and Antiviral Agents have been mentioned in the context of this disorder. Affiliated tissues include t cells, thymus and bone marrow, and related phenotypes are cellular and hematopoietic system

Disease Ontology : 12 A viral infectious disease that results in infection located in brain, or located in meninges, or located in brain and meninges, has material basis in Lymphocytic choriomeningitis virus, which is transmitted by common house mouse, Mus musculus. The infection has symptom fever, has symptom lack of appetite, has symptom headache, has symptom muscle aches, has symptom malaise, has symptom nausea, and has symptom vomiting.

Wikipedia : 74 Lymphocytic choriomeningitis (LCM) is a rodent-borne viral infectious disease that presents as aseptic... more...

Related Diseases for Lymphocytic Choriomeningitis

Diseases related to Lymphocytic Choriomeningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 352)
# Related Disease Score Top Affiliating Genes
1 stomatitis 30.9 IL6 DDX58 CXCL8 ADAR
2 lassa fever 30.7 IRF3 DDX58 DAG1 CLEC4G CD209
3 toxoplasmosis 30.7 TLR2 MYD88 IL6
4 newcastle disease 30.6 MAVS IRF3 DDX58
5 human cytomegalovirus infection 30.6 IRF3 IL6 CXCL8
6 mumps 30.6 IRF9 IL6 CXCL8
7 allergic disease 30.4 TLR2 IL6 ICOSLG CD86 CD80
8 acute transverse myelitis 30.4 IL6 CXCL8
9 herpes simplex 30.4 TLR2 IRF9 IRF3 DDX58 CD209
10 bolivian hemorrhagic fever 30.4 DDX58 DAG1
11 q fever 30.3 TLR2 MYD88 IL6
12 transverse myelitis 30.3 IL6 ICOSLG CXCL8
13 myelitis 30.3 IL6 ICOSLG CXCL8
14 exanthem 30.2 IL6 ICOSLG CXCL8
15 bacterial meningitis 30.2 TLR2 IL6 CXCL8
16 encephalitis 30.1 TLR2 IRF3 IL6 DDX58 DDX3X CLEC4G
17 disease by infectious agent 30.1 TLR2 IL6 ICOSLG CD209
18 haemophilus influenzae 30.1 TLR2 CXCL8
19 influenza 30.1 MYD88 IRF3 IL6 DDX58
20 keratitis, hereditary 30.1 TLR2 IL6 CXCL8
21 trypanosomiasis 30.0 MYD88 IL6 CXCL8
22 hemorrhagic disease 30.0 IRF3 IL6 DDX58 CXCL8 CD209
23 chikungunya 30.0 MAVS IL6 DDX58 CD209
24 west nile virus 29.9 IRF3 DDX58 CD209
25 hepatitis c virus 29.9 MAVS IRF3 DDX58 DDX3X
26 leprosy 3 29.8 TLR2 IL6 CXCL8 CD86 CD209
27 listeriosis 29.7 TLR2 MYD88 IRF3 IL6 ICOSLG
28 autoimmune disease 29.7 IL6 ICOSLG CXCL8 CD86 CD80
29 bacterial infectious disease 29.6 TLR2 MYD88 IL6 ICOSLG CXCL8 CD86
30 colitis 29.5 TLR2 IL6 ICOSLG CXCL8 CD80
31 immune deficiency disease 29.4 TLR2 IL6 ICOSLG CD86 CD80 CD209
32 measles 29.4 TLR2 IRF9 IRF3 IL6 DDX58 CD209
33 systemic lupus erythematosus 28.8 TYRO3 TLR2 MYD88 IRF3 IL6 ICOSLG
34 viral infectious disease 28.6 TLR2 MYD88 MAVS IRF9 IRF3 IL6
35 mollaret meningitis 11.2
36 hydrocephalus 10.6
37 vaccinia 10.6
38 chorioretinitis 10.5
39 aseptic meningitis 10.5
40 meningitis 10.5
41 glomerulonephritis 10.5
42 central nervous system disease 10.5
43 nervous system disease 10.5
44 meningoencephalitis 10.5
45 microcephaly 10.4
46 idiopathic anterior uveitis 10.4 IL6 CXCL8
47 streptococcal toxic-shock syndrome 10.4 IL6 CXCL8
48 cerebellar hypoplasia 10.4
49 rabies 10.4
50 congenital hydrocephalus 10.4

Graphical network of the top 20 diseases related to Lymphocytic Choriomeningitis:



Diseases related to Lymphocytic Choriomeningitis

Symptoms & Phenotypes for Lymphocytic Choriomeningitis

MGI Mouse Phenotypes related to Lymphocytic Choriomeningitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.13 ADAR AXL CD80 CD86 DAG1 DDX3X
2 hematopoietic system MP:0005397 10.07 ADAR AXL CD209 CD80 CD86 CLEC4G
3 homeostasis/metabolism MP:0005376 10.06 ADAR AXL CD209 CD86 CDK15 CLEC4G
4 immune system MP:0005387 9.77 ADAR AXL CD80 CD86 CLEC4G DDX58
5 liver/biliary system MP:0005370 9.23 ADAR AXL CLEC4G DDX58 IL6 MYD88

Drugs & Therapeutics for Lymphocytic Choriomeningitis

Drugs for Lymphocytic Choriomeningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2
2 Antiviral Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Placebo-Controlled, Phase 2 Study of HB-101, a Bivalent Cytomegalovirus (CMV) Vaccine, in CMV-Seronegative Recipient (R-) Patients Awaiting Kidney Transplantation From Living CMV-Seropositive Donors (D+). Recruiting NCT03629080 Phase 2

Search NIH Clinical Center for Lymphocytic Choriomeningitis

Cochrane evidence based reviews: lymphocytic choriomeningitis

Genetic Tests for Lymphocytic Choriomeningitis

Anatomical Context for Lymphocytic Choriomeningitis

MalaCards organs/tissues related to Lymphocytic Choriomeningitis:

40
T Cells, Thymus, Bone Marrow, Brain, B Cells, Spleen, Nk Cells

Publications for Lymphocytic Choriomeningitis

Articles related to Lymphocytic Choriomeningitis:

(show top 50) (show all 3072)
# Title Authors PMID Year
1
Host mechanisms in viral hepatitis. 61 54
20460887 2010
2
Receptor binding and cell entry of Old World arenaviruses reveal novel aspects of virus-host interaction. 61 54
19324387 2009
3
Basolateral entry and release of New and Old World arenaviruses from human airway epithelia. 54 61
18417570 2008
4
Old World arenavirus infection interferes with the expression of functional alpha-dystroglycan in the host cell. 54 61
17761532 2007
5
Posttranslational modification of alpha-dystroglycan, the cellular receptor for arenaviruses, by the glycosyltransferase LARGE is critical for virus binding. 61 54
16254363 2005
6
O Mannosylation of alpha-dystroglycan is essential for lymphocytic choriomeningitis virus receptor function. 61 54
16254364 2005
7
IL-7 receptor alpha chain expression distinguishes functional subsets of virus-specific human CD8+ T cells. 61 54
15947093 2005
8
Electron microscopy of an alpha-dystroglycan fragment containing receptor sites for lymphocytic choriomeningitis virus and laminin, and use of the receptoid body as a reagent to neutralize virus. 54 61
15246261 2004
9
Single-cell lineage mapping of a diverse virus-specific naive CD4 T cell repertoire. 61
33201171 2021
10
Non-neutralizing antibodies protect against chronic LCMV infection by promoting infection of inflammatory monocytes in mice. 61
33547634 2021
11
Screening of Botanical Drugs against Lassa Virus Entry. 61
33536168 2021
12
Th2 cells lacking T-bet suppress naive and memory T cell responses via IL-10. 61
33526653 2021
13
Recombinant lymphocytic choriomeningitis virus-based vaccine vector protects type I interferon receptor deficient mice from viral challenge. 61
33518468 2021
14
The NF-κB regulator Bcl-3 restricts terminal differentiation and promotes memory cell formation of CD8+ T cells during viral infection. 61
33508001 2021
15
Inhibition of Arenaviruses by Combinations of Orally Available Approved Drugs. 61
33468464 2021
16
T cells in the brain enhance neonatal mortality during peripheral LCMV infection. 61
33400715 2021
17
Emerging and Neglected Viruses of Zoonotic Importance in Croatia. 61
33467617 2021
18
Lassa Virus Vaccine Candidate ML29 Generates Truncated Viral RNAs Which Contribute to Interfering Activity and Attenuation. 61
33573250 2021
19
Heterologous Prime Boost Vaccination Induces Protective Melanoma-Specific CD8+ T Cell Responses. 61
33209978 2020
20
An Antiviral Drug Screening Platform with a FRET Biosensor for Measurement of Arenavirus Z Assembly. 61
33191384 2020
21
Sphingosine kinase 2 restricts T cell immunopathology but permits viral persistence. 61
32897877 2020
22
TCRα reporter mice reveal contribution of dual TCRα expression to T cell repertoire and function. 61
33288689 2020
23
PHF14 is required for germinal center B cell development. 61
33035772 2020
24
Differential TLR7-mediated cytokine expression by R848 in M-CSF- versus GM-CSF-derived macrophages after LCMV infection. 61
33331816 2020
25
NK1.1+ innate lymphoid cells in salivary glands inhibit establishment of tissue-resident memory CD8+ T cells in mice. 61
32734619 2020
26
Type I IFNs and CD8 T cells increase intestinal barrier permeability after chronic viral infection. 61
32880630 2020
27
CD85k Contributes to Regulatory T Cell Function in Chronic Viral Infections. 61
33375121 2020
28
Lymphocytic Choriomeningitis Virus Infections and Seroprevalence, Southern Iraq. 61
33219805 2020
29
Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection. 61
33251934 2020
30
High-Throughput Screening of an FDA-Approved Drug Library Identifies Inhibitors against Arenaviruses and SARS-CoV-2. 61
33183004 2020
31
CD49a+CD49b+ NK cells induced by viral infection reflect an activated state of conventional NK cells. 61
32335843 2020
32
T Cell-Intrinsic CX3CR1 Marks the Most Differentiated Effector CD4+ T Cells, but Is Largely Dispensable for CD4+ T Cell Responses during Chronic Viral Infection. 61
33172841 2020
33
The role of MKK4 in T cell development and immunity to viral infections. 61
33175451 2020
34
Interleukin-18 and cytotoxic impairment are independent and synergistic causes of murine virus-induced hyperinflammation. 61
32589707 2020
35
Trigger-dependent differences determine therapeutic outcome in murine primary hemophagocytic lymphohistiocytosis. 61
32419134 2020
36
Tumor-draining lymph node is important for a robust abscopal effect stimulated by radiotherapy. 61
33028691 2020
37
CD8 T cells drive anorexia, dysbiosis, and blooms of a commensal with immunosuppressive potential after viral infection. 61
32958643 2020
38
The thioredoxin-1 inhibitor Txnip restrains effector T-cell and germinal center B-cell expansion. 61
32902872 2020
39
Interrogating Adaptive Immunity Using LCMV. 61
32940427 2020
40
Chronic viral infections impinge on naive bystander CD8 T cells. 61
32220007 2020
41
Type I interferon signaling in fibroblastic reticular cells prevents exhaustive activation of antiviral CD8+ T cells. 61
32917792 2020
42
Seroprevalence of Wenzhou virus in China. 61
32838285 2020
43
Antagonism of interferon signaling by fibroblast growth factors promotes viral replication. 61
32720440 2020
44
Eomes cannot replace its paralog T-bet during expansion and differentiation of CD8 effector T cells. 61
32991634 2020
45
T Cell Receptor Diversity and Lineage Relationship between Virus-Specific CD8 T Cell Subsets during Chronic Lymphocytic Choriomeningitis Virus Infection. 61
32759317 2020
46
Live-attenuated lymphocytic choriomeningitis virus-based vaccines for active immunotherapy of HPV16-positive cancer. 61
33457095 2020
47
Identification of Inhibitors of ZIKV Replication. 61
32961956 2020
48
Effect of Strain Variations on Lassa Virus Z Protein-Mediated Human RIG-I Inhibition. 61
32824946 2020
49
Circulating memory CD8+ T cells are limited in forming CD103+ tissue-resident memory T cells at mucosal sites after reinfection. 61
32762051 2020
50
Lentiviral-Vector-Based Dendritic Cell Vaccine Synergizes with Checkpoint Blockade to Clear Chronic Viral Infection. 61
32497512 2020

Variations for Lymphocytic Choriomeningitis

Expression for Lymphocytic Choriomeningitis

Search GEO for disease gene expression data for Lymphocytic Choriomeningitis.

Pathways for Lymphocytic Choriomeningitis

Pathways related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 TLR2 MYD88 MAVS IRF9 IRF3 IL6
2
Show member pathways
13.34 TYRO3 TLR2 MYD88 IL6 CXCL8 CD80
3
Show member pathways
13.29 MYD88 IRF9 IRF3 IL6 DDX58 CXCL8
4
Show member pathways
12.88 TLR2 MYD88 IRF9 IRF3 IL6 CXCL8
5
Show member pathways
12.8 IL6 ICOSLG DAG1 CXCL8 CD86 CD80
6
Show member pathways
12.67 TLR2 MYD88 IRF3 IL6 CXCL8
7 12.65 TLR2 MYD88 MAVS IRF9 IRF3 IL6
8
Show member pathways
12.58 TLR2 MYD88 MAVS IRF9 IRF3 IL6
9 12.52 TLR2 MYD88 MAVS IRF3 DDX58
10
Show member pathways
12.49 MYD88 MAVS IRF3 IL6 DDX58 ADAR
11
Show member pathways
12.45 MYD88 MAVS IRF3 DDX58 DDX3X CXCL8
12
Show member pathways
12.24 MYD88 IRF3 IL6 CXCL8
13
Show member pathways
12.22 IRF9 IRF3 IL6 CXCL8 ADAR
14
Show member pathways
12.22 TLR2 MYD88 IRF3 IL6 CXCL8
15 12.18 TLR2 MYD88 IL6 CD209
16
Show member pathways
12.16 MYD88 IRF9 IL6 CD209
17
Show member pathways
12.14 TLR2 MYD88 IL6 CXCL8
18 12.04 MYD88 IRF3 IL6 CXCL8
19
Show member pathways
12.03 TLR2 MYD88 MAVS IRF9 IRF3 IL6
20 11.99 MYD88 MAVS IRF9 IRF3 IL6 CXCL8
21 11.96 IL6 CD86 CD80 CD209
22
Show member pathways
11.84 TLR2 IL6 CD86 CD80
23
Show member pathways
11.79 MYD88 IL6 CXCL8
24
Show member pathways
11.75 TLR2 IL6 CD86 CD80
25 11.74 MYD88 IRF3 IL6 CXCL8
26 11.69 TLR2 IL6 CXCL8 CD86 CD80
27 11.63 TLR2 IL6 ICOSLG
28 11.55 TLR2 MYD88 IL6 CXCL8
29 11.46 TLR2 MYD88 IL6 CXCL8
30 11.42 IL6 CXCL8 CD86 CD80
31 10.96 TYRO3 IL6 CXCL8 CD80 AXL
32
Show member pathways
10.92 MAVS IRF9 IRF3 DDX58 ADAR

GO Terms for Lymphocytic Choriomeningitis

Cellular components related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.35 ICOSLG DAG1 CD86 CD80 CD209
2 cell surface GO:0009986 9.1 TYRO3 TLR2 CD86 CD80 CD209 AXL

Biological processes related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 10.09 MYD88 IL6 DDX3X AXL ADAR
2 innate immune response GO:0045087 10.09 TLR2 MYD88 MAVS IRF3 DDX58 DDX3X
3 immune response GO:0006955 10.07 TLR2 IL6 CXCL8 CD86 CD80
4 inflammatory response GO:0006954 10.04 TLR2 MYD88 IL6 CXCL8 AXL
5 positive regulation of gene expression GO:0010628 10.04 TLR2 MYD88 IL6 DDX58 DDX3X CXCL8
6 cytokine-mediated signaling pathway GO:0019221 10.01 MYD88 IL6 CXCL8 CD86 CD80
7 defense response to virus GO:0051607 10 MAVS IRF9 IRF3 IL6 DDX58 ADAR
8 positive regulation of interleukin-6 production GO:0032755 9.91 TLR2 MYD88 MAVS IL6 DDX58
9 positive regulation of tumor necrosis factor production GO:0032760 9.89 TLR2 MYD88 MAVS IL6 DDX58
10 response to virus GO:0009615 9.88 MYD88 DDX58 DDX3X ADAR
11 type I interferon signaling pathway GO:0060337 9.85 MYD88 IRF9 IRF3 ADAR
12 positive regulation of interleukin-8 production GO:0032757 9.85 TLR2 MYD88 MAVS IL6 DDX58
13 phagocytosis GO:0006909 9.84 TYRO3 MYD88 AXL
14 positive regulation of T cell proliferation GO:0042102 9.84 IL6 CD86 CD80 CD209
15 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.83 TLR2 DDX3X CD86
16 T cell costimulation GO:0031295 9.8 ICOSLG CD86 CD80
17 negative regulation of T cell proliferation GO:0042130 9.8 CLEC4G CD86 CD80
18 cellular response to virus GO:0098586 9.8 IRF3 IL6 GBF1 DDX3X ADAR
19 cellular response to lipopolysaccharide GO:0071222 9.8 MYD88 IRF3 IL6 CXCL8 CD86 CD80
20 positive regulation of chemokine production GO:0032722 9.79 TLR2 MYD88 IL6
21 positive regulation of interferon-alpha production GO:0032727 9.78 MAVS IRF3 DDX58 DDX3X
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 TLR2 MYD88 IRF3
23 positive regulation of interferon-beta production GO:0032728 9.77 TLR2 MAVS IRF3 DDX58 DDX3X
24 negative regulation of type I interferon production GO:0032480 9.76 MAVS IRF3 DDX58
25 cellular response to exogenous dsRNA GO:0071360 9.73 MAVS IRF3 DDX58
26 immune system process GO:0002376 9.73 TLR2 MYD88 MAVS IRF9 IRF3 ICOSLG
27 viral entry into host cell GO:0046718 9.7 TYRO3 DAG1 CLEC4G CD86 CD80 CD209
28 positive regulation of type I interferon-mediated signaling pathway GO:0060340 9.69 MAVS IRF3
29 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.68 DDX58 CD80
30 natural killer cell differentiation GO:0001779 9.68 TYRO3 AXL
31 response to molecule of bacterial origin GO:0002237 9.68 TLR2 CXCL8
32 vagina development GO:0060068 9.67 TYRO3 AXL
33 secretion by cell GO:0032940 9.67 TYRO3 AXL
34 ovulation cycle GO:0042698 9.66 TYRO3 AXL
35 response to peptidoglycan GO:0032494 9.65 MYD88 IL6
36 modulation by virus of host morphology or physiology GO:0019048 9.65 DAG1 CD209
37 positive regulation of chemokine (C-C motif) ligand 5 production GO:0071651 9.65 MAVS DDX3X
38 positive regulation of response to cytokine stimulus GO:0060760 9.64 MAVS DDX58
39 positive regulation of myeloid dendritic cell cytokine production GO:0002735 9.63 MAVS DDX58
40 positive regulation of viral life cycle GO:1903902 9.62 TYRO3 CLEC4G CD209 AXL
41 negative regulation of lymphocyte activation GO:0051250 9.61 TYRO3 AXL
42 forebrain cell migration GO:0021885 9.6 TYRO3 AXL
43 viral process GO:0016032 9.4 TYRO3 MAVS IRF3 GBF1 DDX58 DDX3X

Molecular functions related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.96 TYRO3 TLR2 MYD88 MAVS IRF9 IRF3
2 virus receptor activity GO:0001618 9.17 TYRO3 DAG1 CLEC4G CD86 CD80 CD209
3 Toll-like receptor binding GO:0035325 9.16 TLR2 MYD88

Sources for Lymphocytic Choriomeningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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