LCM
MCID: LYM009
MIFTS: 46

Lymphocytic Choriomeningitis (LCM)

Categories: Genetic diseases, Immune diseases, Infectious diseases, Muscle diseases, Neuronal diseases

Aliases & Classifications for Lymphocytic Choriomeningitis

MalaCards integrated aliases for Lymphocytic Choriomeningitis:

Name: Lymphocytic Choriomeningitis 12 54 3 43 15 71 32
Lymphocytic Choriomeningitis Virus Encephalomyelitis 12
Non-Arthropod Borne Lymphocytic Choriomeningitis 71
Lymphocytic Meningoencephalitis 12
Lymphocytic Meningitis 12
Lcm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12155
MeSH 43 D008216
SNOMED-CT 67 38666007
ICD10 32 A87.2
UMLS 71 C0024266 C0153014

Summaries for Lymphocytic Choriomeningitis

CDC : 3 Lymphocytic choriomeningitis, or LCM, is a rodent-borne viral infectious disease caused by lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae, that was initially isolated in 1933. The primary host of LCMV is the common house mouse, Mus musculus. Infection in house mouse populations may vary by geographic location, though it is estimated that 5% of house mice throughout the United States carry LCMV and are able to transmit virus for the duration of their lives without showing any sign of illness. Other types of rodents, such as hamsters, are not the natural reservoirs but can become infected with LCMV from wild mice at the breeder, in the pet store, or home environment. Humans are more likely to contract LCMV from house mice, but infections from pet rodents have also been reported.

MalaCards based summary : Lymphocytic Choriomeningitis, also known as lymphocytic choriomeningitis virus encephalomyelitis, is related to lassa fever and argentine hemorrhagic fever. An important gene associated with Lymphocytic Choriomeningitis is DAG1 (Dystroglycan 1), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and b cells, and related phenotypes are Decreased vesicular stomatitis virus (VSV) infection and Decreased vesicular stomatitis virus (VSV) infection

Disease Ontology : 12 A viral infectious disease that results in infection located in brain, or located in meninges, or located in brain and meninges, has material basis in Lymphocytic choriomeningitis virus, which is transmitted by common house mouse, Mus musculus. The infection has symptom fever, has symptom lack of appetite, has symptom headache, has symptom muscle aches, has symptom malaise, has symptom nausea, and has symptom vomiting.

Wikipedia : 74 Lymphocytic choriomeningitis (LCM) is a rodent-borne viral infectious disease that presents as aseptic... more...

Related Diseases for Lymphocytic Choriomeningitis

Diseases related to Lymphocytic Choriomeningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 332)
# Related Disease Score Top Affiliating Genes
1 lassa fever 30.8 IRF3 DDX58 DAG1 CLEC4G
2 argentine hemorrhagic fever 30.6 IRF3 DDX58 CLEC4G
3 toxoplasmosis 30.5 TLR2 MYD88 IL6
4 vaccinia 30.3 IRF3 IL6 DDX3X CD80
5 q fever 30.3 TLR2 MYD88 IL6
6 mumps 30.3 IRF9 IL6 CXCL8
7 acute transverse myelitis 30.3 IL6 CXCL8
8 bolivian hemorrhagic fever 30.2 IRF3 DDX58 DAG1
9 myelitis 30.1 IL6 ICOSLG CXCL8
10 allergic hypersensitivity disease 30.1 TLR2 ICOSLG CXCL8 CD86
11 cytomegalovirus infection 30.1 IRF3 IL6 CXCL8
12 exanthem 30.0 IL6 ICOSLG CXCL8
13 keratitis, hereditary 29.9 TLR2 IL6 CXCL8
14 encephalitis 29.9 IRF3 IL6 DDX58 DDX3X CLEC4G
15 leprosy 3 29.9 TLR2 IL6 CXCL8
16 trypanosomiasis 29.8 TLR2 MYD88 IL6 CXCL8
17 bacterial meningitis 29.8 TLR2 IL6 CXCL8
18 chikungunya 29.8 MAVS IL6 DDX58
19 leishmaniasis 29.7 TLR2 MYD88 IL6 CXCL8
20 haemophilus influenzae 29.7 TLR2 CXCL8
21 stomatitis 29.6 TLR2 IL6 DDX58 CXCL8 ADAR
22 agammaglobulinemia 29.4 TLR2 IL6 ICOSLG
23 mouth disease 29.4 IRF3 IL6 ICOSLG DDX58
24 autoimmune disease 29.4 IL6 ICOSLG CXCL8 CD86 CD80
25 listeriosis 29.3 TLR2 MYD88 IRF3 IL6 ICOSLG
26 diabetes mellitus, insulin-dependent 29.2 TLR2 IL6 ICOSLG CD86 CD80
27 colitis 29.1 TLR2 IL6 ICOSLG CXCL8
28 bacterial infectious disease 28.8 TLR2 MYD88 IL6 ICOSLG CXCL8 CD86
29 hepatitis c virus 28.6 IRF3 DDX58 DDX3X ADAR
30 measles 28.2 TLR2 MYD88 IRF9 IRF3 IL6 DDX58
31 viral infectious disease 27.4 TLR2 MYD88 MAVS IRF9 IRF3 IL6
32 systemic lupus erythematosus 27.3 TLR2 MYD88 IRF3 IL6 ICOSLG DDX58
33 mollaret meningitis 11.7
34 mantle cell lymphoma 11.6
35 hydrocephalus 10.6
36 chorioretinitis 10.5
37 aseptic meningitis 10.5
38 meningitis 10.5
39 meningoencephalitis 10.5
40 glomerulonephritis 10.5
41 central nervous system disease 10.5
42 nervous system disease 10.5
43 herpes simplex 10.4
44 prosthetic joint infection 10.4 TLR2 IL6
45 microcephaly 10.4
46 pertussis 10.3
47 rabies 10.3
48 cerebellar hypoplasia 10.3
49 congenital hydrocephalus 10.3
50 cytokine deficiency 10.3

Graphical network of the top 20 diseases related to Lymphocytic Choriomeningitis:



Diseases related to Lymphocytic Choriomeningitis

Symptoms & Phenotypes for Lymphocytic Choriomeningitis

GenomeRNAi Phenotypes related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-1 9.17 ADAL ARCN1 CDK15
2 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-2 9.17 ADAL ARCN1 CDK15
3 Decreased vesicular stomatitis virus (VSV) infection GR00356-A-1 9.17 CDK15
4 Decreased lymphocytic choriomeningitis virus (LCMV) infection GR00241-A-3 9.13 ADAL ARCN1 CDK15

MGI Mouse Phenotypes related to Lymphocytic Choriomeningitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.21 ADAR ARCN1 AXL CD80 CD86 DAG1
2 homeostasis/metabolism MP:0005376 10.13 ADAL ADAR AXL CD86 CLEC4G DAG1
3 hematopoietic system MP:0005397 10.1 ADAR AXL CD80 CD86 CLEC4G DDX58
4 immune system MP:0005387 9.97 ADAR AXL CD80 CD86 CLEC4G DDX58
5 liver/biliary system MP:0005370 9.5 ADAR AXL CLEC4G DDX58 IL6 TLR2
6 nervous system MP:0003631 9.4 ADAR ARCN1 AXL CD80 CD86 DAG1

Drugs & Therapeutics for Lymphocytic Choriomeningitis

Drugs for Lymphocytic Choriomeningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2
2 Immunologic Factors Phase 2
3 Antiviral Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Placebo-Control, Phase 2 Study of HB-101, a Bivalent Cytomegalovirus (CMV) Vaccine, in CMV-Seronegative Recipient (R-) Patients Awaiting Kidney Transplantation From Living CMV-Seropositive Donors (D+). Recruiting NCT03629080 Phase 2
2 Randomized, Placebo-controlled, Double-blind Phase I Dose-escalating Trial to Evaluate the Safety and Immunogenicity of a Vaccine Against Human Cytomegalovirus Completed NCT02798692 Phase 1
3 Comparative Study of Peripheral Facial Paralysis Sequelae Based on the Initial Medical Care of Lyme Disease Among Children Recruiting NCT03981874

Search NIH Clinical Center for Lymphocytic Choriomeningitis

Cochrane evidence based reviews: lymphocytic choriomeningitis

Genetic Tests for Lymphocytic Choriomeningitis

Anatomical Context for Lymphocytic Choriomeningitis

MalaCards organs/tissues related to Lymphocytic Choriomeningitis:

40
T Cells, Brain, B Cells, Liver, Bone, Nk Cells, Spleen

Publications for Lymphocytic Choriomeningitis

Articles related to Lymphocytic Choriomeningitis:

(show top 50) (show all 3002)
# Title Authors PMID Year
1
Host mechanisms in viral hepatitis. 54 61
20460887 2010
2
Receptor binding and cell entry of Old World arenaviruses reveal novel aspects of virus-host interaction. 54 61
19324387 2009
3
Basolateral entry and release of New and Old World arenaviruses from human airway epithelia. 54 61
18417570 2008
4
Old World arenavirus infection interferes with the expression of functional alpha-dystroglycan in the host cell. 54 61
17761532 2007
5
Posttranslational modification of alpha-dystroglycan, the cellular receptor for arenaviruses, by the glycosyltransferase LARGE is critical for virus binding. 54 61
16254363 2005
6
O Mannosylation of alpha-dystroglycan is essential for lymphocytic choriomeningitis virus receptor function. 54 61
16254364 2005
7
IL-7 receptor alpha chain expression distinguishes functional subsets of virus-specific human CD8+ T cells. 54 61
15947093 2005
8
Electron microscopy of an alpha-dystroglycan fragment containing receptor sites for lymphocytic choriomeningitis virus and laminin, and use of the receptoid body as a reagent to neutralize virus. 54 61
15246261 2004
9
Wild Red Foxes (Vulpes vulpes) as Sentinels of Rodent-borne Hantavirus and Lymphocytic Choriomeningitis Virus in the Province of Soria, Northern Spain. 61
32011204 2020
10
Map3k14 as a Regulator of Innate and Adaptive Immune Response during Acute Viral Infection. 61
32033109 2020
11
PD-1+ stemlike CD8 T cells are resident in lymphoid tissues during persistent LCMV infection. 61
32034098 2020
12
Genetic Deficiency of Interferon-γ Reveals Interferon-γ-Independent Manifestations of Murine Hemophagocytic Lymphohistiocytosis. 61
31400073 2020
13
Prediction of cancer neoepitopes needs new rules. 61
31952902 2020
14
A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. 61
31786250 2020
15
Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses. 61
31995746 2020
16
Non-apoptotic TRAIL function modulates NK cell activity during viral infection. 61
31742873 2020
17
Virus-induced natural killer cell lysis of T cell subsets. 61
31670188 2020
18
Quantitative and Qualitative Analysis of Humoral Immunity Reveals Continued and Personalized Evolution in Chronic Viral Infection. 61
31995768 2020
19
Correction: Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na+/K+ transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenaviruses. 61
31905217 2020
20
PD-1 Expression during Acute Infection Is Repressed through an LSD1-Blimp-1 Axis. 61
31811020 2020
21
A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control. 61
31954207 2020
22
Vaccinia Virus Vectors Targeting Peptides for MHC Class II Presentation to CD4+ T Cells. 61
31896555 2020
23
Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury. 61
31409605 2020
24
Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function. 61
31784108 2019
25
Programmable Inhibition and Detection of RNA Viruses Using Cas13. 61
31607545 2019
26
Microtubule-dependent transport of arenavirus matrix protein demonstrated using live-cell imaging microscopy. 61
31722015 2019
27
E3 Ligase ITCH Interacts with the Z Matrix Protein of Lassa and Mopeia Viruses and Is Required for the Release of Infectious Particles. 61
31906112 2019
28
Modulation of the humoral immune response by constitutively active STAT6 expression in murine B cells. 61
31803941 2019
29
Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection. 61
31810882 2019
30
Loss of resistance to mousepox during chronic lymphocytic choriomeningitis virus infection is associated with impaired T-cell responses and can be rescued by immunization. 61
31826990 2019
31
LCMV-specific CD4 T cell dependent polyclonal B-cell activation upon persistent viral infection is short lived and extrafollicular. 61
31724162 2019
32
Screening of Forestry Workers in Guadalajara Province (Spain) for Antibodies to Lymphocytic Choriomeningitis Virus, Hantavirus, Rickettsia spp. and Borrelia burgdorferi. 61
31731580 2019
33
NEDD4 family ubiquitin ligases associate with LCMV Z's PPXY domain and are required for virus budding, but not via direct ubiquitination of Z. 61
31710650 2019
34
The Role of Emerging and Neglected Viruses in the Etiology of Hepatitis. 61
31754812 2019
35
Chronic Lymphocytic Choriomeningitis infection causes susceptibility to mousepox and impairs Natural Killer cell maturation and function. 61
31776282 2019
36
PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity. 61
31527834 2019
37
Oncolytic virotherapy enhances the efficacy of a cancer vaccine by modulating the tumor microenvironment. 61
30972741 2019
38
Neuroinvasion and cognitive impairment in comorbid alcohol dependence and chronic viral infection: An initial investigation. 61
31325774 2019
39
Xenoantigen-Dependent Complement-Mediated Neutralization of Lymphocytic Choriomeningitis Virus Glycoprotein-Pseudotyped Vesicular Stomatitis Virus in Human Serum. 61
31243134 2019
40
A unique variant of lymphocytic choriomeningitis virus that induces pheromone binding protein MUP: Critical role for CTL. 61
31427525 2019
41
T Cell-Intrinsic IL-6R Signaling Is Required for Optimal ICOS Expression and Viral Control during Chronic Infection. 61
31413107 2019
42
Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells. 61
31484831 2019
43
Divergent memory responses driven by adenoviral vectors are impacted by epitope competition. 61
31106398 2019
44
Endogenous n-3 Polyunsaturated Fatty Acids Are Beneficial to Dampen CD8+ T Cell-Mediated Inflammatory Response upon the Viral Infection in Mice. 61
31547227 2019
45
The uric acid crystal receptor Clec12A potentiates type I interferon responses. 61
31451663 2019
46
The ReFRAME library as a comprehensive drug repurposing library to identify mammarenavirus inhibitors. 61
31302150 2019
47
Viral Infections and Autoimmune Disease: Roles of LCMV in Delineating Mechanisms of Immune Tolerance. 61
31546586 2019
48
Arenaviruses and West Nile Virus in solid organ transplant recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. 61
31022306 2019
49
Extrinsic Acquisition of CD80 by Antigen-Specific CD8+ T Cells Regulates Their Recall Immune Responses to Acute Viral Infection. 61
31501713 2019
50
A short history of Lassa fever: the first 10-15 years after discovery. 61
31323506 2019

Variations for Lymphocytic Choriomeningitis

Expression for Lymphocytic Choriomeningitis

Search GEO for disease gene expression data for Lymphocytic Choriomeningitis.

Pathways for Lymphocytic Choriomeningitis

Pathways related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 TLR2 MYD88 MAVS IRF9 IRF3 IL6
2
Show member pathways
13.34 TYRO3 TLR2 MYD88 IL6 CXCL8 CD80
3
Show member pathways
13.26 MYD88 IRF9 IRF3 IL6 DDX58 CXCL8
4
Show member pathways
12.85 TLR2 MYD88 IRF9 IRF3 IL6 CXCL8
5
Show member pathways
12.78 IL6 ICOSLG DAG1 CXCL8 CD86 CD80
6 12.64 TLR2 MYD88 MAVS IRF9 IRF3 IL6
7
Show member pathways
12.52 MYD88 MAVS IRF3 IL6 DDX58 DDX3X
8
Show member pathways
12.52 TLR2 MYD88 MAVS IRF9 IRF3 IL6
9 12.5 TLR2 MYD88 MAVS IRF3 DDX58
10
Show member pathways
12.34 MYD88 MAVS IRF3 DDX58
11
Show member pathways
12.3 TLR2 MYD88 MAVS IRF9 IRF3 IL6
12
Show member pathways
12.23 MYD88 IRF3 IL6 CXCL8
13
Show member pathways
12.2 IRF9 IRF3 IL6 CXCL8 ADAR
14
Show member pathways
12.2 TLR2 MYD88 IRF3 IL6 CXCL8
15
Show member pathways
12.15 TLR2 MYD88 IL6 CXCL8
16
Show member pathways
12.12 TLR2 MYD88 IL6 CXCL8
17 12.06 MYD88 MAVS IRF9 IRF3 IL6 CXCL8
18
Show member pathways
11.99 TLR2 IL6 CD86 CD80
19 11.95 MYD88 IRF3 IL6 CXCL8
20
Show member pathways
11.78 MYD88 IL6 CXCL8
21 11.73 TLR2 IL6 CXCL8 CD86 CD80
22 11.72 MYD88 IRF3 IL6 CXCL8
23 11.7 MYD88 IL6 CXCL8
24 11.64 IL6 CD86 CD80
25 11.55 ICOSLG CD86 CD80
26 11.53 TLR2 MYD88 IL6 CXCL8
27 11.46 TLR2 MYD88 IL6 CXCL8
28 11.42 IL6 CXCL8 CD86 CD80
29 10.94 TYRO3 IL6 CXCL8 CD80 AXL
30
Show member pathways
10.72 MAVS IRF9 IRF3 DDX58 ADAR

GO Terms for Lymphocytic Choriomeningitis

Biological processes related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.22 TYRO3 TLR2 MYD88 MAVS IL6 ICOSLG
2 negative regulation of apoptotic process GO:0043066 10.07 MYD88 IL6 DDX3X AXL ADAR
3 immune response GO:0006955 10.06 TLR2 IL6 CXCL8 CD86 CD80
4 positive regulation of gene expression GO:0010628 10.03 TLR2 MYD88 IL6 DDX58 DDX3X
5 inflammatory response GO:0006954 10.01 TLR2 MYD88 IL6 CXCL8 AXL
6 innate immune response GO:0045087 9.97 TLR2 MYD88 MAVS IRF3 DDX58 DDX3X
7 cell surface receptor signaling pathway GO:0007166 9.96 MYD88 IRF9 CD86 CD80
8 defense response to virus GO:0051607 9.91 MAVS IRF9 IRF3 IL6 DDX58 ADAR
9 phagocytosis GO:0006909 9.81 TYRO3 MYD88 AXL
10 positive regulation of T cell proliferation GO:0042102 9.8 IL6 CD86 CD80
11 type I interferon signaling pathway GO:0060337 9.8 MYD88 IRF9 IRF3 ADAR
12 viral entry into host cell GO:0046718 9.8 TYRO3 DAG1 CLEC4G CD86 CD80 AXL
13 cellular response to lipopolysaccharide GO:0071222 9.8 MYD88 IRF3 IL6 CXCL8 CD86 CD80
14 positive regulation of interleukin-6 production GO:0032755 9.78 TLR2 MYD88 IL6 DDX58
15 T cell costimulation GO:0031295 9.77 ICOSLG CD86 CD80
16 negative regulation of T cell proliferation GO:0042130 9.75 CLEC4G CD86 CD80
17 positive regulation of interleukin-6 secretion GO:2000778 9.74 TLR2 MAVS DDX58
18 negative regulation of type I interferon production GO:0032480 9.71 MAVS IRF3 DDX58
19 positive regulation of interleukin-8 production GO:0032757 9.71 TLR2 MYD88 MAVS DDX58
20 cellular response to exogenous dsRNA GO:0071360 9.69 MAVS IRF3 DDX58
21 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.68 CD86 CD80
22 positive regulation of type I interferon-mediated signaling pathway GO:0060340 9.67 MAVS IRF3
23 response to molecule of bacterial origin GO:0002237 9.67 TLR2 CXCL8
24 positive regulation of interferon-alpha secretion GO:1902741 9.65 MAVS DDX58
25 vagina development GO:0060068 9.65 TYRO3 AXL
26 secretion by cell GO:0032940 9.65 TYRO3 AXL
27 viral process GO:0016032 9.65 TYRO3 MAVS IRF3 DDX58 DDX3X DAG1
28 natural killer cell differentiation GO:0001779 9.64 TYRO3 AXL
29 ovulation cycle GO:0042698 9.63 TYRO3 AXL
30 positive regulation of interferon-alpha production GO:0032727 9.63 MAVS IRF3 DDX58
31 positive regulation of response to cytokine stimulus GO:0060760 9.62 MAVS DDX58
32 positive regulation of myeloid dendritic cell cytokine production GO:0002735 9.61 MAVS DDX58
33 positive regulation of chemokine (C-C motif) ligand 5 production GO:0071651 9.59 MAVS DDX3X
34 positive regulation of interferon-beta secretion GO:0035549 9.58 MAVS DDX58
35 negative regulation of lymphocyte activation GO:0051250 9.56 TYRO3 AXL
36 forebrain cell migration GO:0021885 9.55 TYRO3 AXL
37 positive regulation of interferon-beta production GO:0032728 9.55 TLR2 MAVS IRF3 DDX58 DDX3X
38 immune system process GO:0002376 9.36 TLR2 MYD88 MAVS IRF9 IRF3 ICOSLG

Molecular functions related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 TYRO3 TLR2 MYD88 MAVS IRF9 IRF3
2 adenosine deaminase activity GO:0004000 9.26 ADAR ADAL
3 Toll-like receptor binding GO:0035325 9.16 TLR2 MYD88
4 virus receptor activity GO:0001618 9.1 TYRO3 DAG1 CLEC4G CD86 CD80 AXL

Sources for Lymphocytic Choriomeningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....