LCM
MCID: LYM009
MIFTS: 45

Lymphocytic Choriomeningitis (LCM)

Categories: Genetic diseases, Immune diseases, Infectious diseases, Muscle diseases, Neuronal diseases

Aliases & Classifications for Lymphocytic Choriomeningitis

MalaCards integrated aliases for Lymphocytic Choriomeningitis:

Name: Lymphocytic Choriomeningitis 12 55 3 44 15 72 33
Lymphocytic Choriomeningitis Virus Encephalomyelitis 12
Non-Arthropod Borne Lymphocytic Choriomeningitis 72
Lymphocytic Meningoencephalitis 12
Lymphocytic Meningitis 12
Lcm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12155
MeSH 44 D008216
SNOMED-CT 68 38666007
ICD10 33 A87.2
UMLS 72 C0024266 C0153014

Summaries for Lymphocytic Choriomeningitis

CDC : 3 Lymphocytic choriomeningitis, or LCM, is a rodent-borne viral infectious disease caused by lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae, that was initially isolated in 1933. The primary host of LCMV is the common house mouse, Mus musculus. Infection in house mouse populations may vary by geographic location, though it is estimated that 5% of house mice throughout the United States carry LCMV and are able to transmit virus for the duration of their lives without showing any sign of illness. Other types of rodents, such as hamsters, are not the natural reservoirs but can become infected with LCMV from wild mice at the breeder, in the pet store, or home environment. Humans are more likely to contract LCMV from house mice, but infections from pet rodents have also been reported.

MalaCards based summary : Lymphocytic Choriomeningitis, also known as lymphocytic choriomeningitis virus encephalomyelitis, is related to lassa fever and mollaret meningitis. An important gene associated with Lymphocytic Choriomeningitis is DAG1 (Dystroglycan 1), and among its related pathways/superpathways are Golgi-to-ER retrograde transport and Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF). The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and b cells, and related phenotypes are Decreased influenza A virus infection and Decreased influenza A virus infection

Disease Ontology : 12 A viral infectious disease that results in infection located in brain, or located in meninges, or located in brain and meninges, has material basis in Lymphocytic choriomeningitis virus, which is transmitted by common house mouse, Mus musculus. The infection has symptom fever, has symptom lack of appetite, has symptom headache, has symptom muscle aches, has symptom malaise, has symptom nausea, and has symptom vomiting.

Wikipedia : 75 Lymphocytic choriomeningitis (LCM) is a rodent-borne viral infectious disease that presents as aseptic... more...

Related Diseases for Lymphocytic Choriomeningitis

Diseases related to Lymphocytic Choriomeningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 208)
# Related Disease Score Top Affiliating Genes
1 lassa fever 30.9 DAG1 AXL
2 mollaret meningitis 11.7
3 mantle cell lymphoma 11.6
4 hydrocephalus 10.6
5 congenital hydrocephalus 10.6
6 vaccinia 10.6
7 chorioretinitis 10.5
8 aseptic meningitis 10.5
9 meningitis 10.5
10 stomatitis 10.5
11 meningoencephalitis 10.5
12 glomerulonephritis 10.5
13 central nervous system disease 10.5
14 nervous system disease 10.5
15 allergic hypersensitivity disease 10.5
16 encephalitis 10.4
17 herpes simplex 10.4
18 cerebellar hypoplasia 10.3
19 pertussis 10.3
20 rabies 10.3
21 growth hormone deficiency 10.3
22 cytokine deficiency 10.3
23 rubella 10.3
24 toxoplasmosis 10.3
25 microencephaly 10.3
26 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
27 argentine hemorrhagic fever 10.2
28 mumps 10.2
29 viral meningitis 10.2
30 leukemia 10.2
31 newcastle disease 10.2
32 microcephaly 10.2
33 ataxia and polyneuropathy, adult-onset 10.2
34 tick-borne encephalitis 10.2
35 neutropenia 10.2
36 cerebral palsy 10.2
37 myelitis 10.2
38 syphilis 10.2
39 hypoglycemia 10.2
40 meningitis and encephalitis 10.2
41 tuberculous meningitis 10.1
42 autoimmune disease 10.1
43 hydrocephalus, congenital, 1 10.1
44 yemenite deaf-blind hypopigmentation syndrome 10.1
45 branchiootic syndrome 1 10.1
46 aplastic anemia 10.1
47 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.1
48 hydrops, lactic acidosis, and sideroblastic anemia 10.1
49 exanthem 10.1
50 neuroretinitis 10.1

Graphical network of the top 20 diseases related to Lymphocytic Choriomeningitis:



Diseases related to Lymphocytic Choriomeningitis

Symptoms & Phenotypes for Lymphocytic Choriomeningitis

GenomeRNAi Phenotypes related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased influenza A virus infection GR00147-A-1 10.36 ARCN1 ATP6V0B COPA COPB2
2 Decreased influenza A virus infection GR00147-A-2 10.36 ARCN1 ATP6V0B COPA COPB2
3 Decreased Hepatitis C virus replication GR00180-A-1 10.3 ARCN1 COPA COPB2
4 Decreased Hepatitis C virus replication GR00180-A-2 10.3 ARCN1 COPA COPB2
5 Decreased shRNA abundance GR00251-A-1 10.23 ARCN1 CLEC4G COPA COPB2 DAG1 MYD88
6 Decreased shRNA abundance GR00251-A-2 10.23 ARCN1 CLEC4G COPA COPB2 DAG1 MYD88
7 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-1 10.05 ARCN1 ATP6AP2 ATP6V0B CARD14 COPA COPB2
8 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-2 10.05 ARCN1 ATP6AP2 ATP6V0B CARD14 COPA COPB2
9 Decreased lymphocytic choriomeningitis virus (LCMV) infection GR00241-A-3 9.95 ARCN1 ARF1 ATP6AP2 ATP6V0B CARD14 COPA
10 Decreased influenza A/WSN/33 replication GR00195-A-1 9.73 ARCN1 ATP6AP2 COPA COPB2
11 Decreased human parainfluenza virus type 3 (HPIV3) infection GR00241-A-4 9.69 ARCN1 COPA COPB2
12 Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers GR00195-A-3 9.67 ATP6AP2 COPA COPB2
13 Decreased influenza A H1N1 (A/WSN/33) virus numbers GR00195-A-2 9.65 ATP6AP2 COPA COPB2
14 Decreased Salmonella-containing vacuole maturation GR00133-A-2 9.65 ARCN1 ATP6AP2 COPA COPB2 TYRO3
15 Decreased Salmonella enterica Typhimurium binding GR00133-A-3 9.54 ARCN1 ARF1 COPA
16 Decreased Salmonella enterica Typhimurium ruffling GR00133-A-5 9.5 ARCN1 COPA COPB2
17 Increased Sindbis virus (SINV) infection GR00310-A-1 9.02 ARCN1 ATP6AP2 COPA COPB2
18 Increased Sindbis virus (SINV) infection GR00310-A-2 9.02 ARCN1

MGI Mouse Phenotypes related to Lymphocytic Choriomeningitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.23 ARCN1 ATP6AP2 AXL COPB2 DAG1 DDX3X

Drugs & Therapeutics for Lymphocytic Choriomeningitis

Drugs for Lymphocytic Choriomeningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2
2 Immunologic Factors Phase 2
3 Antiviral Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Placebo-Control, Phase 2 Study of HB-101, a Bivalent Cytomegalovirus (CMV) Vaccine, in CMV-Seronegative Recipient (R-) Patients Awaiting Kidney Transplantation From Living CMV-Seropositive Donors (D+). Recruiting NCT03629080 Phase 2
2 Randomized, Placebo-controlled, Double-blind Phase I Dose-escalating Trial to Evaluate the Safety and Immunogenicity of a Vaccine Against Human Cytomegalovirus Completed NCT02798692 Phase 1
3 Comparative Study of Peripheral Facial Paralysis Sequelae Based on the Initial Medical Care of Lyme Disease Among Children Recruiting NCT03981874

Search NIH Clinical Center for Lymphocytic Choriomeningitis

Cochrane evidence based reviews: lymphocytic choriomeningitis

Genetic Tests for Lymphocytic Choriomeningitis

Anatomical Context for Lymphocytic Choriomeningitis

MalaCards organs/tissues related to Lymphocytic Choriomeningitis:

41
T Cells, Brain, B Cells, Nk Cells, Liver, Spleen, Bone

Publications for Lymphocytic Choriomeningitis

Articles related to Lymphocytic Choriomeningitis:

(show top 50) (show all 2965)
# Title Authors PMID Year
1
Host mechanisms in viral hepatitis. 9 38
20460887 2010
2
Receptor binding and cell entry of Old World arenaviruses reveal novel aspects of virus-host interaction. 9 38
19324387 2009
3
Basolateral entry and release of New and Old World arenaviruses from human airway epithelia. 9 38
18417570 2008
4
Old World arenavirus infection interferes with the expression of functional alpha-dystroglycan in the host cell. 9 38
17761532 2007
5
O Mannosylation of alpha-dystroglycan is essential for lymphocytic choriomeningitis virus receptor function. 9 38
16254364 2005
6
Posttranslational modification of alpha-dystroglycan, the cellular receptor for arenaviruses, by the glycosyltransferase LARGE is critical for virus binding. 9 38
16254363 2005
7
IL-7 receptor alpha chain expression distinguishes functional subsets of virus-specific human CD8+ T cells. 9 38
15947093 2005
8
Electron microscopy of an alpha-dystroglycan fragment containing receptor sites for lymphocytic choriomeningitis virus and laminin, and use of the receptoid body as a reagent to neutralize virus. 9 38
15246261 2004
9
Oncolytic virotherapy enhances the efficacy of a cancer vaccine by modulating the tumor microenvironment. 38
30972741 2019
10
The ReFRAME library as a comprehensive drug repurposing library to identify mammarenavirus inhibitors. 38
31302150 2019
11
Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury. 38
31409605 2019
12
T Cell-Intrinsic IL-6R Signaling Is Required for Optimal ICOS Expression and Viral Control during Chronic Infection. 38
31413107 2019
13
A unique variant of lymphocytic choriomeningitis virus that induces pheromone binding protein MUP: Critical role for CTL. 38
31427525 2019
14
Mechanisms of action of ruxolitinib in murine models of hemophagocytic lymphohistiocytosis. 38
31015190 2019
15
Neuroinvasion and cognitive impairment in comorbid alcohol dependence and chronic viral infection: An initial investigation. 38
31325774 2019
16
RSV Vaccine Based on Rhabdoviral Vector Protects after Single Immunization. 38
31277325 2019
17
A short history of Lassa fever: the first 10-15 years after discovery. 38
31323506 2019
18
TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection. 38
31207605 2019
19
IFN-γ and CD25 drive distinct pathologic features during hemophagocytic lymphohistiocytosis. 38
30578871 2019
20
NK cell-intrinsic FcεRIγ limits CD8+ T-cell expansion and thereby turns an acute into a chronic viral infection. 38
31220194 2019
21
Systems analysis reveals complex biological processes during virus infection fate decisions. 38
31138618 2019
22
The long noncoding RNA Morrbid regulates CD8 T cells in response to viral infection. 38
31138702 2019
23
Viral Strain Determines Disease Symptoms, Pathology, and Immune Response in Neonatal Rats with Lymphocytic Choriomeningitis Virus Infection. 38
31207945 2019
24
Xenoantigen-dependent complement-mediated neutralization of LCMV glycoprotein pseudotyped VSV in human serum. 38
31243134 2019
25
Enhancing immunity prevents virus-induced T-cell-mediated immunopathology in B cell-deficient mice. 38
30793761 2019
26
Divergent memory responses driven by adenoviral vectors are impacted by epitope competition. 38
31106398 2019
27
Arenaviruses and West Nile Virus in solid organ transplant recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. 38
31022306 2019
28
Obesity Expands a Distinct Population of T Cells in Adipose Tissue and Increases Vulnerability to Infection. 38
30970254 2019
29
High Constitutive Interleukin 10 Level Interferes With the Immune Response to Varicella-Zoster Virus in Elderly Recipients of Live Attenuated Zoster Vaccine. 38
30445431 2019
30
Identification of a Locus in Mice that Regulates the Collateral Damage and Lethality of Virus Infection. 38
31042467 2019
31
Infection drives meningeal engraftment by inflammatory monocytes that impairs CNS immunity. 38
30886419 2019
32
Metabolic Reprogramming by the Excessive AMPK Activation Exacerbates Antigen-Specific Memory CD8+ T Cell Differentiation after Acute Lymphocytic Choriomeningitis Virus Infection. 38
31089438 2019
33
The ubiquitin-like modifier FAT10 is required for normal IFN-γ production by activated CD8+ T cells. 38
30818228 2019
34
Residual LCMV antigen in transiently CD4+ T cell-depleted mice induces high levels of virus-specific antibodies but only limited B-cell memory. 38
30636035 2019
35
Sustained Type I Interferon Reinforces NK Cell-Mediated Cancer Immunosurveillance during Chronic Virus Infection. 38
30808680 2019
36
The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection. 38
30842630 2019
37
Cutting Edge: Early Attrition of Memory T Cells during Inflammation and Costimulation Blockade Is Regulated Concurrently by Proapoptotic Proteins Fas and Bim. 38
30610162 2019
38
Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain. 38
30557576 2019
39
Immune Exhaustion: Past Lessons and New Insights from Lymphocytic Choriomeningitis Virus. 38
30781904 2019
40
Induction of Tier 1 HIV Neutralizing Antibodies by Envelope Trimers Incorporated into a Replication Competent Vesicular Stomatitis Virus Vector. 38
30769947 2019
41
Complexities of Type I Interferon Biology: Lessons from LCMV. 38
30791575 2019
42
Liver-Resident NK Cells Control Antiviral Activity of Hepatic T Cells via the PD-1-PD-L1 Axis. 38
30709740 2019
43
Choline acetyltransferase-expressing T cells are required to control chronic viral infection. 38
30733420 2019
44
IL-33 induces immunosuppressive neutrophils via a type 2 innate lymphoid cell/IL-13/STAT6 axis and protects the liver against injury in LCMV infection-induced viral hepatitis. 38
29400707 2019
45
TLR4 signaling improves PD-1 blockade therapy during chronic viral infection. 38
30726291 2019
46
Absence of keratin 1 restricts the course of infection with lymphocytic choriomeningitis virus strain MX. 38
31230446 2019
47
Simultaneous rapid detection of Hantaan virus and Seoul virus using RT-LAMP in rats. 38
30643674 2019
48
Aging of Antiviral CD8+ Memory T Cells Fosters Increased Survival, Metabolic Adaptations, and Lymphoid Tissue Homing. 38
30552164 2019
49
Mechanisms of lymphatic system-specific viral replication and its potential role in autoimmune disease. 38
30444956 2019
50
Lymphocytic choriomeningitis virus meningitis after needlestick injury: a case report. 38
31139360 2019

Variations for Lymphocytic Choriomeningitis

Expression for Lymphocytic Choriomeningitis

Search GEO for disease gene expression data for Lymphocytic Choriomeningitis.

Pathways for Lymphocytic Choriomeningitis

Pathways related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.08 COPB2 COPA ARF1 ARCN1
2 10.3 COPB2 COPA ARF1 ARCN1
3 10.21 COPA ARF1

GO Terms for Lymphocytic Choriomeningitis

Cellular components related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 9.73 COPB2 COPA ARF1 ARCN1
2 transport vesicle GO:0030133 9.43 COPB2 COPA ARCN1
3 membrane coat GO:0030117 9.37 COPB2 COPA
4 COPI-coated vesicle GO:0030137 9.16 ARF1 ARCN1
5 COPI vesicle coat GO:0030126 9.13 COPB2 COPA ARCN1
6 COPI-coated vesicle membrane GO:0030663 8.8 COPB2 COPA ARCN1
7 membrane GO:0016020 10.06 TYRO3 DDX3X DAG1 COPB2 COPA CLEC4G
8 cytoplasm GO:0005737 10.01 MYD88 DDX3X DAG1 COPB2 COPA CARD14

Biological processes related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 protein transport GO:0015031 9.88 COPB2 COPA ARF1 ARCN1
2 intracellular protein transport GO:0006886 9.81 COPB2 COPA ARF1 ARCN1
3 Wnt signaling pathway GO:0016055 9.74 TYRO3 DDX3X AXL
4 ER to Golgi vesicle-mediated transport GO:0006888 9.71 COPB2 COPA ARCN1
5 vesicle-mediated transport GO:0016192 9.67 COPB2 COPA ARF1 ARCN1
6 viral process GO:0016032 9.65 TYRO3 DDX3X DAG1 CLEC4G AXL
7 negative regulation of apoptotic process GO:0043066 9.62 MYD88 DDX3X CARD14 AXL
8 substrate adhesion-dependent cell spreading GO:0034446 9.58 TYRO3 AXL
9 retrograde vesicle-mediated transport, Golgi to ER GO:0006890 9.58 COPB2 COPA ARCN1
10 protein kinase B signaling GO:0043491 9.56 TYRO3 AXL
11 intra-Golgi vesicle-mediated transport GO:0006891 9.55 COPB2 COPA
12 apoptotic cell clearance GO:0043277 9.52 TYRO3 AXL
13 natural killer cell differentiation GO:0001779 9.49 TYRO3 AXL
14 vagina development GO:0060068 9.48 TYRO3 AXL
15 secretion by cell GO:0032940 9.46 TYRO3 AXL
16 ovulation cycle GO:0042698 9.43 TYRO3 AXL
17 negative regulation of lymphocyte activation GO:0051250 9.16 TYRO3 AXL
18 forebrain cell migration GO:0021885 8.96 TYRO3 AXL
19 viral entry into host cell GO:0046718 8.92 TYRO3 DAG1 CLEC4G AXL

Molecular functions related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Wnt-protein binding GO:0017147 9.16 TYRO3 AXL
2 phosphatidylinositol 3-kinase binding GO:0043548 8.96 TYRO3 AXL
3 virus receptor activity GO:0001618 8.92 TYRO3 DAG1 CLEC4G AXL

Sources for Lymphocytic Choriomeningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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