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MCID: LYM042
MIFTS: 40

Lymphocytic Colitis

Categories: Blood diseases, Gastrointestinal diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Lymphocytic Colitis

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MalaCards integrated aliases for Lymphocytic Colitis:

Name: Lymphocytic Colitis 12 73 20 15 17
Colitis, Lymphocytic 44 70

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases Immune diseases Blood diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060184
MeSH 44 D046730
NCIt 50 C27147
SNOMED-CT 67 31437008
ICD10 32 K52.832
UMLS 70 C0400822
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Summaries for Lymphocytic Colitis

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GARD : 20 Lymphocytic colitis is form of microscopic colitis, a condition that is characterized by inflammation of the colon (large intestines). As the name suggests, microscopic colitis can only be diagnosed by examining a small sample of colon tissue under a microscope. In lymphocytic colitis, specifically, the tissues and lining of the colon are of normal thickness, but an increase in the number of lymphocytes (a type of white blood cell ) is observed. Signs and symptoms of the condition may include chronic, watery diarrhea; abdominal pain, cramping, and bloating; weight loss; nausea; dehydration; and/or fecal incontinence. The underlying cause of lymphocytic colitis is currently unknown; however, scientists suspect that autoimmune conditions, medications, infections, genetic factors, and/or bile acid malabsorption may contribute to the development of the condition. Treatment is based on the signs and symptoms present in each person and may include certain medications, dietary modifications, and in rare cases, surgery.

MalaCards based summary : Lymphocytic Colitis, also known as colitis, lymphocytic, is related to collagenous colitis and microscopic colitis. An important gene associated with Lymphocytic Colitis is CHGA (Chromogranin A), and among its related pathways/superpathways are Salmonella infection (KEGG) and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. The drugs Budesonide and Analgesics, Non-Narcotic have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and t cells, and related phenotypes are growth/size/body region and homeostasis/metabolism

Disease Ontology : 12 A colitis characterized by an accumulation of lymphocytes in the colonic epithelium and connective tissue (lamina propria).

Wikipedia : 73 Lymphocytic colitis is a subtype of microscopic colitis, a condition characterized by chronic non-bloody... more...

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Related Diseases for Lymphocytic Colitis

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Diseases related to Lymphocytic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 269)
# Related Disease Score Top Affiliating Genes
1 collagenous colitis 32.2 MMP9 CLDN4 CHGA
2 microscopic colitis 30.9 TOR1A TNF TGM2 ATP4A ATP12A
3 carcinoid syndrome 30.2 PYY CHGA
4 gastritis 30.2 TNF CHGA ATP4A
5 angiodysplasia 30.1 ATP4A ATP12A
6 functional diarrhea 30.0 ATP4A ATP12A
7 zollinger-ellison syndrome 29.9 CHGA ATP4A ATP12A
8 pernicious anemia 29.9 CHGA ATP4A ATP12A
9 irritable bowel syndrome 29.7 TNF TGM2 PYY CHGA
10 gastroesophageal reflux 29.4 TNF PYY ATP4A ATP12A
11 diverticulitis 29.4 TNF MMP9 ATP4A ATP12A
12 inflammatory bowel disease 29.3 TNF PYY PTGER4 MMP9 CHGA CD8A
13 immunoglobulin alpha deficiency 29.2 TOR1A TGM2 CD8A
14 lymphocytic gastritis 29.1 TOR1A CD8A ATP4A ATP12A
15 exanthem 29.0 TNF CD8A ATP4A ATP12A
16 celiac disease 1 28.8 TOR1A TNF TGM2 PYY CD8A ATP4A
17 duodenitis 28.3 TOR1A TNF TGM2 CD8A ATP4A ATP12A
18 collagenous gastritis 11.1
19 colitis 10.9
20 diarrhea 10.7
21 endometrial small cell carcinoma 10.4 PYY CHGA
22 vulvar eccrine porocarcinoma 10.4 PTGER4 CHGA
23 papillary thymic adenocarcinoma 10.4 PTGER4 CHGA
24 peritoneal serous papillary adenocarcinoma 10.4 PTGER4 CLDN4
25 postgastrectomy syndrome 10.3 PYY ATP12A
26 malignant spiradenoma 10.3 PTGER4 CLDN4
27 ulcerative colitis 10.3
28 meckel diverticulum 10.3 CHGA ATP4A
29 vagus nerve disease 10.2 ATP4A ATP12A
30 necrotizing gastritis 10.2 ATP4A ATP12A
31 scalp dermatosis 10.2 ATP4A ATP12A
32 hemangioma of intra-abdominal structure 10.2 ATP4A ATP12A
33 acquired gastric outlet stenosis 10.2 ATP4A ATP12A
34 lingual goiter 10.2 ATP4A ATP12A
35 displacement of cardia through esophageal hiatus 10.2 ATP4A ATP12A
36 bacterial esophagitis 10.2 ATP4A ATP12A
37 cascade stomach 10.2 ATP4A ATP12A
38 benzylpenicillin allergy 10.2 ATP4A ATP12A
39 median arcuate ligament syndrome 10.2 ATP4A ATP12A
40 afferent loop syndrome 10.2 ATP4A ATP12A
41 cervix erosion 10.2 ATP4A ATP12A
42 angiodysplasia of intestine 10.2 ATP4A ATP12A
43 peritoneal serous adenocarcinoma 10.2 PTGER4 CLDN4 CHGA
44 granulomatous gastritis 10.2 ATP4A ATP12A
45 laryngeal tuberculosis 10.2 ATP4A ATP12A
46 fungal esophagitis 10.2 ATP4A ATP12A
47 dieulafoy lesion 10.2 ATP4A ATP12A
48 esophagus melanoma 10.2 ATP4A ATP12A
49 cefuroxime allergy 10.2 ATP4A ATP12A
50 emphysematous cholecystitis 10.2 ATP4A ATP12A

Graphical network of the top 20 diseases related to Lymphocytic Colitis:



Diseases related to Lymphocytic Colitis
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Symptoms & Phenotypes for Lymphocytic Colitis

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MGI Mouse Phenotypes related to Lymphocytic Colitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.9 ATP12A ATP4A CHGA CLDN4 CLDN8 MMP9
2 homeostasis/metabolism MP:0005376 9.7 ATP12A ATP4A CHGA CLDN4 CLDN8 MMP9
3 renal/urinary system MP:0005367 9.17 ATP12A CD8A CHGA CLDN4 CLDN8 MMP9
Sources

Drugs & Therapeutics for Lymphocytic Colitis

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Drugs for Lymphocytic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Budesonide Approved Phase 2, Phase 3 51333-22-3 63006 5281004
2 Analgesics, Non-Narcotic Phase 3
3 Antirheumatic Agents Phase 3
4 Analgesics Phase 3
5 Mesalamine Phase 3 89-57-6
6 Anti-Inflammatory Agents, Non-Steroidal Phase 3
7 Respiratory System Agents Phase 2, Phase 3
8 Hormones Phase 2, Phase 3
9 Hormone Antagonists Phase 2, Phase 3
10 glucocorticoids Phase 2, Phase 3
11 Anti-Asthmatic Agents Phase 2, Phase 3
12 Bronchodilator Agents Phase 2, Phase 3
13 Anti-Inflammatory Agents Phase 2, Phase 3
14 Pharmaceutical Solutions
15 Cola
16 Gastrointestinal Agents
17 Antacids
18 Anti-Ulcer Agents
19
Bismuth 7440-69-9 16682734 105143

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Budesonide for Treatment of Lymphocytic Colitis Completed NCT00180050 Phase 3 Budesonide
2 Double-blind, Double-dummy, Randomised, Placebo-controlled, Multi-centre Phase III Study on the Efficacy and Tolerability of a 8-week Treatment With Budesonide vs. Mesalazine vs. Placebo in Patients With Lymphocytic Colitis Completed NCT01209208 Phase 3 Budesonide;Mesalamine
3 A Randomized, Double-Blind, Placebo Controlled Trial of Budesonide for the Treatment of Active Lymphocytic Colitis Terminated NCT00217022 Phase 2, Phase 3 Budesonide
4 Prospective Study on the Usefulness of Chromoendoscopy in Detecting Microscopic Colitis in Patients Undergoing Colonoscopy Due to Chronic Watery Diarrhoea Unknown status NCT01504048
5 Risk Factors for Microscopic Colitis: A Dutch Case-Control Study Completed NCT01928667
6 Treatment of Microscopic Colitis (Collagenous Colitis and Lymphocytic Colitis) With Budesonide, Bismuth or Fiber Terminated NCT00184171 Budesonide;Bismuth;Fiber

Search NIH Clinical Center for Lymphocytic Colitis

Cochrane evidence based reviews: colitis, lymphocytic

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Genetic Tests for Lymphocytic Colitis

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Anatomical Context for Lymphocytic Colitis

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MalaCards organs/tissues related to Lymphocytic Colitis:

40
Colon, Small Intestine, T Cells, Endothelial, Neutrophil
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Publications for Lymphocytic Colitis

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Articles related to Lymphocytic Colitis:

(show top 50) (show all 549)
# Title Authors PMID Year
1
Medication-specific variations in morphological patterns of injury in immune check-point inhibitor-associated colitis. 61
32931028 2021
2
Microscopic lymphocytic colitis due to duloxetine: Case report and review of the literature. 61
33039169 2021
3
Olmesartan-induced lymphocytic colitis: a specific gap in the guideline? 61
33582319 2021
4
Association Between Collagenous and Lymphocytic Colitis and Risk of Severe Coronavirus Disease 2019. 61
33610527 2021
5
European guidelines on microscopic colitis: United European Gastroenterology and European Microscopic Colitis Group statements and recommendations. 61
33619914 2021
6
Histopathology of Non-IBD Colitis. A practical approach from the Italian Group for the study of the gastrointestinal tract (GIPAD). 61
33686310 2021
7
Collagenous colitis and atezolizumab therapy: an atypical case. 61
33151423 2021
8
Serotonin in the Pathogenesis of Lymphocytic Colitis. 61
33466782 2021
9
Distribution of histopathological features along the colon in microscopic colitis. 61
32920702 2021
10
Gastrointestinal Infection and Risk of Microscopic Colitis: A Nationwide Case-Control Study in Sweden. 61
33421519 2021
11
Bile Acid Sequestrant Therapy in Microscopic Colitis. 61
33443968 2021
12
Lymphocytic and collagenous colitis in children and adolescents: Comprehensive clinicopathologic analysis with long-term follow-up. 61
32991931 2020
13
Lymphocytic Colitis With Increased Apoptosis: A Marker of Mutation in T-Cell-Mediated Immunity? 61
32955408 2020
14
Inflammatory colitis associated with Teriflunomide. 61
32942118 2020
15
High risk of microscopic colitis after Campylobacter concisus infection: population-based cohort study. 61
32111632 2020
16
Lymphocytic colitis in the setting of teriflunomide use for relapsing multiple sclerosis. 61
32031458 2020
17
Commentary on "Lymphocytic colitis in the setting of teriflunomide use for relapsing multiple sclerosis". 61
32031463 2020
18
Disease activity patterns, mortality and colorectal cancer risk in microscopic colitis: a Danish nationwide cohort study, 2001 to 2016. 61
33049029 2020
19
Overview of microscopic colitis. 61
33135914 2020
20
Increasing Incidence of Microscopic Colitis in a Population-Based Cohort Study in Switzerland. 61
33065310 2020
21
Colitis nucleomigrans: The third type of microscopic colitis (part 1). 61
32761850 2020
22
Topographical distribution of microscopic colitis and the importance of orientation of paraffin-embedded biopsies. 61
32673680 2020
23
Campylobacter concisus is prevalent in the gastrointestinal tract of patients with microscopic colitis. 61
32667235 2020
24
Biopsies From Ascending and Descending Colon Are Sufficient for Diagnosis of Microscopic Colitis. 61
32109628 2020
25
European guidelines on microscopic colitis: United European Gastroenterology (UEG) and European Microscopic Colitis Group (EMCG) statements and recommendations. 61
32819215 2020
26
All-cause and cause-specific mortality in microscopic colitis: a Danish nationwide matched cohort study. 61
32583929 2020
27
Lymphocytic colitis pattern of injury presenting as endoscopic polyps: a case series. 61
32387106 2020
28
Aquaporin-5 Expression Is Reduced in Lymphocytic Colitis. 61
32826239 2020
29
Digestive involvement in primary Sjögren's syndrome: analysis from the Sjögrenser registry. 61
33025900 2020
30
Colonic mucosal inflammatory cells in children and adolescents with lactase deficiency. 61
32331918 2020
31
Incidence and prevalence of microscopic colitis between 2001 and 2016: A Danish nationwide cohort study. 61
32502240 2020
32
An investigation of European pathologists' approach to diagnose microscopic colitis. 61
32278285 2020
33
Diagnosing Primary Sclerosing Cholangitis in Children. 61
32617210 2020
34
Successful Treatment of Lymphocytic Colitis With a Honey Lavage. 61
31968094 2020
35
The association between smoking and both types of microscopic colitis: A systematic review and meta-analysis. 61
32241698 2020
36
Histopathologic Patterns of Colitis in Patients With Impaired Renal Function. 61
31679016 2020
37
Clinicopathological significance of lymphocytic colitis/collagenous colitis in inflammatory bowel disease. 61
31698005 2020
38
Clinical characteristics of colitis induced by taxane-based chemotherapy. 61
31892799 2020
39
Treatment of microscopic colitis: the role of budesonide and new alternatives for refractory patients. 61
31880163 2020
40
Undiagnosed microscopic colitis: a hidden cause of chronic diarrhoea and a frequently missed treatment opportunity. 61
32419914 2020
41
Increased Mast Cell Counts and Degranulation in Microscopic Colitis. 61
32148478 2020
42
Immune-related adverse events in the gastrointestinal tract: diagnostic utility of upper gastrointestinal biopsies. 61
31361907 2020
43
Faecal Calprotectin and 7-α Cholestenone Levels in Microscopic Colitis: Experience from Edinburgh. 61
32440188 2020
44
Effects of subspecialty signout and group consensus on the diagnosis of microscopic colitis. 61
31359149 2019
45
Establishment of digital cutoff values for intraepithelial lymphocytes in biopsies from colonic mucosa with lymphocytic colitis. 61
31522788 2019
46
Long-Term Natural History of Microscopic Colitis: A Population-Based Cohort. 61
31478957 2019
47
Lymphocytic colitis-like pattern of mucosal injury and the challenges in diagnosing cancer immunotherapy-related toxicity. 61
30892689 2019
48
A nationwide cohort study of the incidence of microscopic colitis in Sweden. 61
30983010 2019
49
Lymphocytic colitis in an HIV positive patient: is dolutegravir the cause? 61
31045946 2019
50
Microscopic colitis: pathophysiology and clinical management. 61
30860066 2019
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Variations for Lymphocytic Colitis

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Expression for Lymphocytic Colitis

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Search GEO for disease gene expression data for Lymphocytic Colitis.
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Pathways for Lymphocytic Colitis

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Pathways related to Lymphocytic Colitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Salmonella infection (KEGG) 36
Show member pathways
 12.21 TNF CLDN8 CLDN5 CLDN4
2
Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways 64
Show member pathways
 11.84 MMP9 CLDN8 CLDN5 CLDN4
3
Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview 64
Show member pathways
 11.48 CLDN8 CLDN5 CLDN4
4
Cell adhesion molecules 36
11.1 CLDN8 CLDN5 CLDN4 CD8A
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GO Terms for Lymphocytic Colitis

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Cellular components related to Lymphocytic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tight junction GO:0070160 9.16 CLDN5 CLDN4
2 bicellular tight junction GO:0005923 9.13 CLDN8 CLDN5 CLDN4
3 apicolateral plasma membrane GO:0016327 8.8 CLDN8 CLDN5 CLDN4

Biological processes related to Lymphocytic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular sodium ion homeostasis GO:0006883 9.43 ATP4A ATP12A
2 organelle organization GO:0006996 9.4 TOR1A CHGA
3 sodium ion export across plasma membrane GO:0036376 9.37 ATP4A ATP12A
4 positive regulation of inflammatory response GO:0050729 9.33 TNF TGM2 PTGER4
5 cellular potassium ion homeostasis GO:0030007 9.32 ATP4A ATP12A
6 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.26 ATP4A ATP12A
7 bicellular tight junction assembly GO:0070830 9.13 CLDN8 CLDN5 CLDN4
8 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO:0016338 8.8 CLDN8 CLDN5 CLDN4

Molecular functions related to Lymphocytic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.7 TOR1A TNF TGM2 MMP9 CLDN8 CLDN5
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP4A ATP12A
3 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
4 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A
Sources

Sources for Lymphocytic Colitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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