MCID: LYM042
MIFTS: 38

Lymphocytic Colitis

Categories: Rare diseases, Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Lymphocytic Colitis

MalaCards integrated aliases for Lymphocytic Colitis:

Name: Lymphocytic Colitis 12 76 53 15
Colitis, Lymphocytic 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060184
ICD10 33 K52.89
MeSH 44 D046730
NCIt 50 C27147
SNOMED-CT 68 31437008
UMLS 73 C0400822

Summaries for Lymphocytic Colitis

NIH Rare Diseases : 53 Lymphocytic colitis is form of microscopic colitis, a condition that is characterized by inflammation of the colon (large intestines). As the name suggests, microscopic colitis can only be diagnosed by examining a small sample of colon tissue under a microscope. In lymphocytic colitis, specifically, the tissues and lining of the colon are of normal thickness, but an increase in the number of lymphocytes (a type of white blood cell) is observed. Signs and symptoms of the condition may include chronic, watery diarrhea; abdominal pain, cramping, and bloating; weight loss; nausea; dehydration; and/or fecal incontinence. The underlying cause of lymphocytic colitis is currently unknown; however, scientists suspect that autoimmune conditions, medications, infections, genetic factors, and/or bile acid malabsorption may contribute to the development of the condition. Treatment is based on the signs and symptoms present in each person and may include certain medications, dietary modifications, and in rare cases, surgery.

MalaCards based summary : Lymphocytic Colitis, also known as colitis, lymphocytic, is related to collagenous colitis and microscopic colitis. An important gene associated with Lymphocytic Colitis is CHGA (Chromogranin A), and among its related pathways/superpathways is Celecoxib Pathway, Pharmacodynamics. The drugs Budesonide and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include colon, endothelial and monocytes, and related phenotype is homeostasis/metabolism.

Disease Ontology : 12 A colitis characterized by an accumulation of lymphocytes in the colonic epithelium and connective tissue (lamina propria).

Wikipedia : 76 Lymphocytic colitis is a subtype of microscopic colitis, a condition characterized by chronic non-bloody... more...

Related Diseases for Lymphocytic Colitis

Diseases related to Lymphocytic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 collagenous colitis 32.3 CD79A CHGA
2 microscopic colitis 32.3 ATP12A CD79A
3 duodenitis 28.9 ATP12A ATP4A CD79A
4 peritoneal serous adenocarcinoma 10.7 CHGA PTGER4
5 auditory system cancer 10.6 CHGA MMP9
6 colitis 10.6
7 carcinoid syndrome 10.5 CHGA PYY
8 chronic follicular conjunctivitis 10.4 CD79A MMP9
9 blepharochalasis 10.4 CD79A MMP9
10 fungal esophagitis 10.3 ATP12A ATP4A
11 bladder calculus 10.3 ATP12A ATP4A
12 neonatal candidiasis 10.3 ATP12A ATP4A
13 photoallergic dermatitis 10.3 ATP12A ATP4A
14 squamous papillomatosis 10.3 ATP12A ATP4A
15 acute laryngitis 10.3 ATP12A ATP4A
16 gastroduodenal crohn's disease 10.3 ATP12A ATP4A
17 toxic megacolon 10.3 ATP12A ATP4A
18 aspiration pneumonitis 10.3 ATP12A ATP4A
19 postsurgical hypothyroidism 10.3 ATP12A ATP4A
20 gastric antral vascular ectasia 10.3 ATP12A ATP4A
21 parotitis 10.3 CD79A MMP9
22 esophageal candidiasis 10.3 ATP12A ATP4A
23 rumination disorder 10.3 ATP12A ATP4A
24 bile reflux 10.3 ATP12A ATP4A
25 granulomatous gastritis 10.3 ATP12A ATP4A
26 active peptic ulcer disease 10.3 ATP12A ATP4A
27 laryngeal disease 10.3 ATP12A ATP4A
28 ischemic neuropathy 10.3 ATP12A ATP4A
29 capillary disease 10.3 ATP12A ATP4A
30 peptic esophagitis 10.3 ATP12A ATP4A
31 duodenal disease 10.3 ATP12A ATP4A
32 dyskinesia of esophagus 10.3 ATP12A ATP4A
33 serotonin syndrome 10.3 CHGA PYY
34 hernia, hiatus 10.3 ATP12A ATP4A
35 congenital disorder of deglycosylation 10.3 ATP12A ATP4A
36 anismus 10.3 ATP12A ATP4A
37 esophageal atresia/tracheoesophageal fistula 10.3 ATP12A ATP4A
38 laryngitis 10.3 ATP12A ATP4A
39 laryngeal tuberculosis 10.3 ATP12A ATP4A
40 clostridium difficile colitis 10.3 ATP12A ATP4A
41 lower urinary tract calculus 10.2 ATP12A ATP4A
42 aspiration pneumonia 10.2 ATP12A ATP4A
43 diarrhea 1, secretory chloride, congenital 10.2 ATP12A ATP4A
44 chronic laryngitis 10.2 ATP12A ATP4A
45 chronic intestinal vascular insufficiency 10.2 ATP12A ATP4A
46 eosinophilic gastritis 10.2 ATP12A ATP4A
47 polyposis, skin pigmentation, alopecia, and fingernail changes 10.2 ATP12A ATP4A
48 esophageal varix 10.2 ATP12A ATP4A
49 esophagus adenocarcinoma 10.2 ATP12A ATP4A
50 myopathy, x-linked, with excessive autophagy 10.2 ATP12A ATP4A

Graphical network of the top 20 diseases related to Lymphocytic Colitis:



Diseases related to Lymphocytic Colitis

Symptoms & Phenotypes for Lymphocytic Colitis

MGI Mouse Phenotypes related to Lymphocytic Colitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.23 ATP12A ATP4A CD79A CHGA IRAK2 MMP9

Drugs & Therapeutics for Lymphocytic Colitis

Drugs for Lymphocytic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Budesonide Approved Phase 3,Phase 2,Not Applicable 51333-22-3 63006 5281004
2 Analgesics Phase 3
3 Analgesics, Non-Narcotic Phase 3
4 Anti-Asthmatic Agents Phase 3,Phase 2,Not Applicable
5 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
6 Anti-Inflammatory Agents, Non-Steroidal Phase 3
7 Antirheumatic Agents Phase 3
8 Autonomic Agents Phase 3,Phase 2,Not Applicable
9 Bronchodilator Agents Phase 3,Phase 2,Not Applicable
10 glucocorticoids Phase 3,Phase 2,Not Applicable
11 Hormone Antagonists Phase 3,Phase 2,Not Applicable
12 Hormones Phase 3,Phase 2,Not Applicable
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
14 Mesalamine Phase 3 89-57-6
15 Peripheral Nervous System Agents Phase 3,Phase 2,Not Applicable
16 Respiratory System Agents Phase 3,Phase 2,Not Applicable
17 Pharmaceutical Solutions Not Applicable
18 Antacids Not Applicable
19 Anti-Ulcer Agents Not Applicable
20
Bismuth Not Applicable 7440-69-9 16682734 105143
21 Gastrointestinal Agents Not Applicable
22 Cola Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Budesonide Versus Mesalazine Versus Placebo in Lymphocytic Colitis Completed NCT01209208 Phase 3 Budesonide;Mesalamine
2 Budesonide Treatment for Lymphocytic Colitis Completed NCT00180050 Phase 3 Budesonide
3 Budesonide Versus Placebo for the Treatment of Lymphocytic Colitis Terminated NCT00217022 Phase 2, Phase 3 Budesonide
4 Usefulness of Chromoendoscopy in Diagnosing Microscopic Colitis Unknown status NCT01504048 Not Applicable
5 Case-Control Study to Identify Risk Factors for Microscopic Colitis Completed NCT01928667
6 Treatment of Microscopic Colitis Terminated NCT00184171 Not Applicable Budesonide;Bismuth;Fiber

Search NIH Clinical Center for Lymphocytic Colitis

Cochrane evidence based reviews: colitis, lymphocytic

Genetic Tests for Lymphocytic Colitis

Anatomical Context for Lymphocytic Colitis

MalaCards organs/tissues related to Lymphocytic Colitis:

41
Colon, Endothelial, Monocytes, Small Intestine

Publications for Lymphocytic Colitis

Articles related to Lymphocytic Colitis:

(show top 50) (show all 118)
# Title Authors Year
1
Lymphocytic Colitis: Pathologic predictors of response to therapy. ( 29452215 )
2018
2
Evaluation of Melatonin Secretion and Metabolism Exponents in Patients with Ulcerative and Lymphocytic Colitis. ( 29382152 )
2018
3
Atypical Colonoscopic Presentation of Lymphocytic Colitis Mimicking Hyperplastic Polyposis Syndrome. ( 29637040 )
2018
4
Microscopic Colitis: A Review of Collagenous and Lymphocytic Colitis. ( 29230146 )
2017
5
Epithelial barrier dysfunction in lymphocytic colitis through cytokine-dependent internalization of claudin-5 and -8. ( 28138755 )
2017
6
Interventions for treating lymphocytic colitis. ( 28702956 )
2017
7
Bullous Pemphigoid with Lymphocytic Colitis: A Case Report and Short Literature Review. ( 27469343 )
2016
8
CD3 immunohistochemical staining in diagnosis of lymphocytic colitis. ( 26772395 )
2016
9
HLA Associations Distinguish Collagenous From Lymphocytic Colitis. ( 27481432 )
2016
10
Microscopic colitis: a descriptive clinical cohort study of 795 patients with collagenous and lymphocytic colitis. ( 26679722 )
2016
11
Cat Scratch Colon in a Patient With Lymphocytic Colitis. ( 27580771 )
2016
12
ENaC Dysregulation Through Activation of MEK1/2 Contributes to Impaired Na+ Absorption in Lymphocytic Colitis. ( 26658215 )
2016
13
Lymphocytic colitis complicated by a mass in the terminal ileum. ( 26034326 )
2015
14
Clinical characteristics and patterns and predictors of response to therapy in collagenous and lymphocytic colitis. ( 25997458 )
2015
15
Increased Production of Lysozyme Associated with Bacterial Proliferation in Barrett's Esophagitis, Chronic Gastritis, Gluten-induced Atrophic Duodenitis (Celiac Disease), Lymphocytic Colitis, Collagenous Colitis, Ulcerative Colitis and Crohn's Colitis. ( 26637845 )
2015
16
Association of lymphocytic colitis and lactase deficiency in pediatric population. ( 25523228 )
2015
17
Does Lymphocytic Colitis Always Present with Normal Endoscopic Findings? ( 25167800 )
2014
18
Clinical presentation, diagnosis, pathogenesis and treatment options for lymphocytic colitis (Review). ( 23695201 )
2013
19
Macroscopic Findings in Lymphocytic Colitis. ( 24211291 )
2013
20
Lymphocytic colitis is associated with increased pro-inflammatory cytokine profile and up regulation of prostaglandin receptor EP4. ( 23613969 )
2013
21
Stable incidence of collagenous colitis and lymphocytic colitis in A9rebro, Sweden, 1999-2008: a continuous epidemiologic study. ( 23945183 )
2013
22
Cryptosporidiosis-associated lymphocytic colitis. ( 23912411 )
2013
23
In vivo diagnosis of lymphocytic colitis by confocal laser endomicroscopy. ( 22851663 )
2013
24
Lymphocytic colitis secondary to ipilimumab treatment. ( 22114048 )
2013
25
High densities of serotonin and peptide YY cells in the colon of patients with lymphocytic colitis. ( 23155335 )
2012
26
Systematic review: are lymphocytic colitis and collagenous colitis two subtypes of the same disease - microscopic colitis? ( 22670660 )
2012
27
Lymphocytic colitis and collagenous colitis: a review of clinicopathologic features and immunologic abnormalities. ( 22156832 )
2012
28
Letter: are lymphocytic colitis and collagenous colitis really the same disease? ( 22913854 )
2012
29
Are collagenous and lymphocytic colitis different aspects of the same disease? ( 23016916 )
2012
30
Duloxetine-induced lymphocytic colitis. ( 22874808 )
2012
31
The behavior of matrix metalloproteinase-9 in lymphocytic colitis, collagenous colitis and ulcerative colitis. ( 21678108 )
2012
32
Chromogranin A cell density as a diagnostic marker for lymphocytic colitis. ( 22699394 )
2012
33
The various faces of autoimmune endocrinopathies: non-tumoral hypergastrinemia in a patient with lymphocytic colitis and chronic autoimmune gastritis. ( 23043903 )
2012
34
MPA: a treatment option for lymphocytic colitis and mesalamine-induced interstitial nephritis. ( 22147390 )
2012
35
Cardiac arrest due to lymphocytic colitis: a case report. ( 22405093 )
2012
36
Evolution of the incidence of collagenous colitis and lymphocytic colitis in Terrassa, Spain: a population-based study. ( 20878755 )
2011
37
High chromogranin A cell density in the colon of patients with lymphocytic colitis. ( 21584496 )
2011
38
Unique endoscopic findings in lymphocytic colitis. ( 22305502 )
2011
39
Pediatric lymphocytic colitis presenting with intractable diarrhea. ( 21543998 )
2011
40
Lymphocytic colitis presenting as difficult diarrhoea in an African woman: a case report and review of the literature. ( 20205879 )
2010
41
Differences in the T-bet and GATA-3 expression patterns between lymphocytic colitis and coeliac disease. ( 20809338 )
2010
42
A retrospective study on a cohort of patients with lymphocytic colitis. ( 20575599 )
2010
43
Lymphocytic colitis in Satoyoshi syndrome. ( 20710153 )
2010
44
Lymphocytic colitis under treatment with duloxetine. ( 20517807 )
2010
45
Enterocolic lymphocytic phlebitis and lymphocytic colitis: drug-related coexistent pathology. ( 18758788 )
2009
46
Large intestine: Remission of lymphocytic colitis with budesonide. ( 19713982 )
2009
47
Collagenous and lymphocytic colitis: systematic review and update of the literature. ( 20203510 )
2009
48
Paucicellular lymphocytic colitis: is it a minor form of lymphocytic colitis? A clinical pathological and immunological study. ( 19352342 )
2009
49
Budesonide is effective in treating lymphocytic colitis: a randomized double-blind placebo-controlled study. ( 19303012 )
2009
50
Nodular lymphoid hyperplasia and histologic changes mimicking celiac disease, collagenous sprue, and lymphocytic colitis in a patient with selective IgA deficiency. ( 19286327 )
2009

Variations for Lymphocytic Colitis

Expression for Lymphocytic Colitis

Search GEO for disease gene expression data for Lymphocytic Colitis.

Pathways for Lymphocytic Colitis

Pathways related to Lymphocytic Colitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.39 MMP9 PTGER4

GO Terms for Lymphocytic Colitis

Biological processes related to Lymphocytic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 JNK cascade GO:0007254 9.4 IRAK2 PTGER4
2 potassium ion import GO:0010107 9.37 ATP12A ATP4A
3 ATP hydrolysis coupled proton transport GO:0015991 9.32 ATP12A ATP4A
4 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
5 cellular potassium ion homeostasis GO:0030007 9.16 ATP12A ATP4A
6 sodium ion export across plasma membrane GO:0036376 8.96 ATP12A ATP4A
7 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP12A ATP4A

Molecular functions related to Lymphocytic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Lymphocytic Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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