MCID: LYM015
MIFTS: 32

Lymphocytic Gastritis

Categories: Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Lymphocytic Gastritis

MalaCards integrated aliases for Lymphocytic Gastritis:

Name: Lymphocytic Gastritis 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:4035
NCIt 50 C27051
UMLS 72 C1283271

Summaries for Lymphocytic Gastritis

MalaCards based summary : Lymphocytic Gastritis is related to acute graft versus host disease and collagenous gastritis. An important gene associated with Lymphocytic Gastritis is GZMB (Granzyme B), and among its related pathways/superpathways are Apoptosis Modulation and Signaling and Allograft rejection. The drugs Esomeprazole and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include t cells, testes and liver, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Lymphocytic Gastritis

Diseases related to Lymphocytic Gastritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 acute graft versus host disease 29.7 GZMB FASLG
2 collagenous gastritis 11.7
3 gastritis 10.8
4 helicobacter pylori infection 10.5
5 chronic erosive gastritis 10.4
6 celiac disease 1 10.3
7 orbit lymphoma 10.3 TIA1 GZMB
8 lymphomatoid granulomatosis 10.3 TIA1 GZMB
9 primary cutaneous anaplastic large cell lymphoma 10.3 TIA1 GZMB
10 composite lymphoma 10.3 TIA1 GZMB
11 hepatosplenic t-cell lymphoma 10.3 TIA1 GZMB
12 giardiasis 10.3 TIA1 GZMB
13 infiltrating lipoma 10.3 TIA1 GZMB
14 dyspepsia 10.2
15 necrotizing sialometaplasia 10.2 TIA1 GZMB
16 ileum cancer 10.2 TIA1 GZMB
17 angioimmunoblastic t-cell lymphoma 10.2 TIA1 GZMB
18 cowpox 10.2 GZMB FAS
19 autoimmune lymphoproliferative syndrome, type v 10.2 TIA1 FAS
20 reticulosarcoma 10.2 TIA1 GZMB
21 gastric adenocarcinoma 10.2
22 breast medullary carcinoma 10.1 GZMB FASLG
23 lymphoma 10.1
24 t-cell large granular lymphocyte leukemia 10.1 GZMB FASLG
25 peripheral t-cell lymphoma 10.1 TIA1 GZMB
26 erythema multiforme 10.1 GZMB FASLG
27 gastric lymphoma 10.0
28 adenocarcinoma 10.0
29 peptic ulcer disease 10.0
30 type ii mixed cryoglobulinemia 10.0 FASLG FAS
31 autoimmune lymphoproliferative syndrome 10.0 FASLG FAS
32 lymphoproliferative syndrome 10.0 FASLG FAS
33 acute myocarditis 10.0 FASLG FAS
34 cutaneous t cell lymphoma 10.0 TIA1 GZMB
35 cartilage-hair hypoplasia 10.0 FASLG FAS
36 alopecia areata 10.0 GZMB FASLG
37 lymphoma, mucosa-associated lymphoid type 10.0
38 thrombophilia due to thrombin defect 10.0
39 gastric cancer 10.0
40 hydrops, lactic acidosis, and sideroblastic anemia 10.0
41 collagenous colitis 10.0
42 lymphocytic colitis 10.0
43 diarrhea 10.0
44 iron metabolism disease 10.0
45 crohn's disease 10.0
46 central nervous system tuberculosis 10.0 FASLG FAS
47 epstein-barr virus-associated gastric carcinoma 9.9 FASLG FAS
48 mycosis fungoides 9.9 TIA1 GZMB
49 silicosis 9.9 FASLG FAS
50 pneumoconiosis 9.8 FASLG FAS

Graphical network of the top 20 diseases related to Lymphocytic Gastritis:



Diseases related to Lymphocytic Gastritis

Symptoms & Phenotypes for Lymphocytic Gastritis

GenomeRNAi Phenotypes related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.17 FAS GZMB TIA1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.17 FAS FASLG GZMB TIA1

Drugs & Therapeutics for Lymphocytic Gastritis

Drugs for Lymphocytic Gastritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Esomeprazole Approved, Investigational Phase 3 119141-88-7, 161796-78-7, 161973-10-0 9568614 4594
2 Gastrointestinal Agents Phase 3
3 Antacids Phase 3
4 Proton Pump Inhibitors Phase 3
5 Anti-Ulcer Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Double-Blind, Randomized, Placebo-Controlled Multicenter Trial on the Efficacy of Esomeprazole Treatment for Patients With Lymphocytic Gastritis Unknown status NCT00455754 Phase 3 Esomeprazole

Search NIH Clinical Center for Lymphocytic Gastritis

Genetic Tests for Lymphocytic Gastritis

Anatomical Context for Lymphocytic Gastritis

MalaCards organs/tissues related to Lymphocytic Gastritis:

41
T Cells, Testes, Liver, Pancreas, Salivary Gland, Neutrophil

Publications for Lymphocytic Gastritis

Articles related to Lymphocytic Gastritis:

(show top 50) (show all 179)
# Title Authors PMID Year
1
Non-malignant Helicobacter pylori-Associated Diseases. 38
31016630 2019
2
Lymphocytic Gastritis Overshadowed by Gastric Mucosa-Associated Lymphoid Tissue Lymphoma. 38
30773956 2019
3
Lymphocytic gastritis induced by pembrolizumab in a patient with metastatic melanoma. 38
30256271 2018
4
Associations of Microscopic Colitis With Other Lymphocytic Disorders of the Gastrointestinal Tract. 38
29535059 2018
5
The differential diagnosis of Helicobacter pylori negative gastritis. 38
30255340 2018
6
Subtypes of chronic gastritis in patients with celiac disease before and after gluten-free diet. 38
29026594 2017
7
Recurrent anaemia in a patient with lymphocytic gastritis and vitamin B12 deficiency. 38
28943131 2017
8
Rare Gastric Lesions Associated with Helicobacter pylori Infection: A Histopathological Review. 38
28592787 2017
9
Transverse Myelitis as Manifestation of Celiac Disease in a Toddler. 38
28153851 2017
10
Development of lymphocytic gastritis with recurrent Helicobacter pylori infection. 38
28211221 2017
11
Lymphocytic Gastritis Identified by Abnormal PET Scan. 38
28462239 2017
12
Propionibacterium acnes overabundance and natural killer group 2 member D system activation in corpus-dominant lymphocytic gastritis. 38
27538697 2016
13
The pathological findings seen in laparoscopic sleeve gastrectomies for weight loss. 38
27020497 2016
14
Pathological and Clinical Correlation between Celiac Disease and Helicobacter Pylori Infection; a Review of Controversial Reports. 38
27252814 2016
15
Lymphocytic gastritis: clinical, endoscopic and histopathologic features. 38
27532536 2016
16
Letter: lymphocytic gastritis and coeliac disease. 38
26331558 2015
17
Letter: lymphocytic gastritis and coeliac disease - authors' reply. 38
26331559 2015
18
The coeliac stomach: gastritis in patients with coeliac disease. 38
25973720 2015
19
Collagenous gastritis: a morphologic and immunohistochemical study of 40 patients. 38
25234289 2015
20
Lymphocytic gastritis is not associated with active Helicobacter pylori infection. 38
24826984 2014
21
Gastric adenocarcinoma in common variable immunodeficiency: features of cancer and associated gastritis may be characteristic of the condition. 38
24788529 2014
22
Helicobacter pylori Associated Lymphocytic Gastritis in a Child. 38
25349835 2014
23
Lymphocytic gastritis showing concomitant occurrence of both CD4 + and CD8 + T-cells among epithelial cells. 38
25047508 2014
24
Pathology and differential diagnosis of chronic, noninfectious gastritis. 38
24815937 2014
25
High proportion of granzyme B+ intraepithelial lymphocytes contributes to epithelial apoptosis in Helicobacter pylori-associated lymphocytic gastritis. 38
23356909 2013
26
Iron deficiency anemia due to lymphocytic gastritis with Helicobacter pylori infection in childhood: case report. 38
23528908 2013
27
Endoscopic, ultrasonographic, and pathologic correlation of lymphocytic gastritis. 38
23716104 2013
28
Endoscopic and histological gastric lesions in children with celiac disease: mucosal involvement is not only confined to the duodenum. 38
22773062 2012
29
Diffuse type gastric carcinoma presenting as giant gastric folds: lessons learned from six miss diagnosed cases. 38
22651965 2012
30
Neutrophilic infiltration in gluten-sensitive enteropathy is neither uncommon nor insignificant: assessment of duodenal biopsies from 267 pediatric and adult patients. 38
22531172 2012
31
Severe spruelike enteropathy associated with olmesartan. 38
22728033 2012
32
Gastrointestinal pathology in celiac disease: a case series of 150 consecutive newly diagnosed patients. 38
22706856 2012
33
Hypovitaminosis D as predisposing factor for atrophic type A gastritis: a case-control study and review of the literature on the interaction of Vitamin D with the immune system. 38
21286859 2012
34
Lymphocytic gastritis in pediatric celiac disease. 38
21244234 2011
35
Gastritis in Alaskan racing sled dogs. 38
21247587 2011
36
Gastroduodenal mucosa in microscopic colitis. 38
21291294 2011
37
Clinical presentation and salivary gland histopathology of paediatric primary Sjögren's syndrome. 38
21640054 2011
38
[Functional condition of the stomach, pancreas, liver and gallbladder in celiac disease]. 38
21516844 2011
39
Collagenous gastritis. 38
19103610 2010
40
Helicobacter pylori-negative gastritis: seek, yet ye shall not always find. 38
20631607 2010
41
Endoscopic portrayal of lymphocytic gastritis in a child. 38
20639772 2010
42
Collagenous sprue is not always associated with dismal outcomes: a clinicopathological study of 19 patients. 38
19855376 2010
43
Collagenous sprue: a clinicopathologic study of 12 cases. 38
19641452 2009
44
[Helicobacter pylori infection in children with celiac disease]. 38
20191880 2009
45
Lymphocytic disorders of the gastrointestinal tract: a review for the practicing pathologist. 38
19700939 2009
46
Intraepithelial lymphocytes in duodenum from Brazilian adolescents with type 1 diabetes. Influence of Helicobacter pylori. 38
19017282 2009
47
Collagenous gastritis: histopathologic features and association with other gastrointestinal diseases. 38
19295410 2009
48
Presentation and long-term follow-up of refractory celiac disease: comparison of type I with type II. 38
19014942 2009
49
[Lymphocytic gastritis and Menetrier's disease: one or two diseases?]. 38
18703299 2009
50
Lymphocytic gastritis and celiac disease in indian children: evidence of a positive relation. 38
18979579 2008

Variations for Lymphocytic Gastritis

Expression for Lymphocytic Gastritis

Search GEO for disease gene expression data for Lymphocytic Gastritis.

Pathways for Lymphocytic Gastritis

Pathways related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.4 GZMB FASLG FAS
2
Show member pathways
12.36 GZMB FASLG FAS CD8A
3
Show member pathways
12.18 GZMB FASLG FAS
4
Show member pathways
12.11 GZMB FASLG FAS
5 11.97 GZMB FASLG FAS CD8A
6
Show member pathways
11.8 GZMB FASLG FAS
7
Show member pathways
11.49 GZMB FASLG CD8A
8
Show member pathways
11.47 FASLG FAS
9 11.44 GZMB CD8A
10 11.37 FASLG FAS
11 11.2 FASLG FAS
12 11.19 TIA1 GZMB FASLG FAS
13 11.12 FASLG FAS
14 11 FASLG FAS
15
Show member pathways
10.92 GZMB FASLG CD8A

GO Terms for Lymphocytic Gastritis

Biological processes related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.58 FASLG FAS CD8A
2 apoptotic process GO:0006915 9.46 TIA1 GZMB FASLG FAS
3 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.43 FASLG FAS
4 apoptotic signaling pathway GO:0097190 9.37 FASLG FAS
5 extrinsic apoptotic signaling pathway GO:0097191 9.32 FASLG FAS
6 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.26 FASLG FAS
7 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 8.96 FASLG FAS
8 necroptotic signaling pathway GO:0097527 8.62 FASLG FAS

Sources for Lymphocytic Gastritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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