MCID: LYM015
MIFTS: 33

Lymphocytic Gastritis

Categories: Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Lymphocytic Gastritis

MalaCards integrated aliases for Lymphocytic Gastritis:

Name: Lymphocytic Gastritis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4035
NCIt 49 C27051
UMLS 71 C1283271

Summaries for Lymphocytic Gastritis

MalaCards based summary : Lymphocytic Gastritis is related to gastric lymphoma and bile reflux. An important gene associated with Lymphocytic Gastritis is GZMB (Granzyme B), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Allograft rejection. The drugs Esomeprazole and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and liver, and related phenotype is renal/urinary system.

Related Diseases for Lymphocytic Gastritis

Diseases related to Lymphocytic Gastritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 199)
# Related Disease Score Top Affiliating Genes
1 gastric lymphoma 30.1 ATP4A ATP12A
2 bile reflux 29.8 ATP4A ATP12A
3 autoimmune gastritis 29.7 ATP4A ATP12A
4 microinvasive gastric cancer 29.7 ATP4A ATP12A
5 vitamin b12 deficiency 29.6 ATP4A ATP12A
6 exanthem 29.4 CD8A ATP4A ATP12A
7 lymphoma, non-hodgkin, familial 29.2 TIA1 GZMB FAS CD8A
8 microscopic colitis 28.3 TOR1A TGM2 ATP4A ATP12A
9 celiac disease 1 28.2 TOR1A TGM2 GZMB CD8A ATP4A ATP12A
10 lymphocytic colitis 28.0 TOR1A TGM2 CD8A ATP4A ATP12A
11 duodenitis 27.7 TOR1A TGM2 CD8A ATP4A ATP12A
12 collagenous gastritis 11.7
13 gastritis 10.8
14 helicobacter pylori infection 10.5
15 chronic erosive gastritis 10.4
16 lymphomatoid granulomatosis 10.4 TIA1 GZMB
17 breast lipoma 10.4 TIA1 GZMB
18 primary cutaneous anaplastic large cell lymphoma 10.4 TIA1 GZMB
19 hepatosplenic t-cell lymphoma 10.4 TIA1 GZMB
20 composite lymphoma 10.4 TIA1 GZMB
21 nasal cavity lymphoma 10.3 TIA1 GZMB
22 t-cell lymphoma, subcutaneous panniculitis-like 10.3 TIA1 GZMB
23 type ii mixed cryoglobulinemia 10.3 FASLG FAS
24 epstein-barr virus-associated gastric carcinoma 10.2 FASLG FAS
25 caspase 8 deficiency 10.2 FASLG FAS
26 hantavirus hemorrhagic fever with renal syndrome 10.2 GZMB CD8A
27 pancreatic vasoactive intestinal peptide producing tumor 10.2 ATP4A ATP12A
28 hemangioma of intra-abdominal structure 10.2 ATP4A ATP12A
29 displacement of cardia through esophageal hiatus 10.2 ATP4A ATP12A
30 gastric hemangioma 10.2 ATP4A ATP12A
31 acquired gastric outlet stenosis 10.2 ATP4A ATP12A
32 angiodysplasia of intestine 10.2 ATP4A ATP12A
33 angiodysplasia 10.2 ATP4A ATP12A
34 benzylpenicillin allergy 10.2 ATP4A ATP12A
35 median arcuate ligament syndrome 10.2 ATP4A ATP12A
36 lymphoma 10.2
37 gastric adenocarcinoma 10.2
38 granulomatous gastritis 10.2 ATP4A ATP12A
39 scleredema adultorum 10.2 FAS CD8A
40 bacterial esophagitis 10.2 ATP4A ATP12A
41 lingual goiter 10.2 ATP4A ATP12A
42 cascade stomach 10.2 ATP4A ATP12A
43 gastrojejunal ulcer 10.2 ATP4A ATP12A
44 fungal esophagitis 10.2 ATP4A ATP12A
45 gastric gastrinoma 10.2 ATP4A ATP12A
46 fungal gastritis 10.2 ATP4A ATP12A
47 superior mesenteric artery syndrome 10.1 ATP4A ATP12A
48 cervix erosion 10.1 ATP4A ATP12A
49 t-cell large granular lymphocyte leukemia 10.1 GZMB FASLG
50 pneumatosis cystoides intestinalis 10.1 ATP4A ATP12A

Graphical network of the top 20 diseases related to Lymphocytic Gastritis:



Diseases related to Lymphocytic Gastritis

Symptoms & Phenotypes for Lymphocytic Gastritis

MGI Mouse Phenotypes related to Lymphocytic Gastritis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.02 ATP12A CD8A FAS FASLG TGM2

Drugs & Therapeutics for Lymphocytic Gastritis

Drugs for Lymphocytic Gastritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Esomeprazole Approved, Investigational Phase 3 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
2 Gastrointestinal Agents Phase 3
3 Proton Pump Inhibitors Phase 3
4 Anti-Ulcer Agents Phase 3
5 Antacids Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Double-Blind, Randomized, Placebo-Controlled Multicenter Trial on the Efficacy of Esomeprazole Treatment for Patients With Lymphocytic Gastritis Unknown status NCT00455754 Phase 3 Esomeprazole

Search NIH Clinical Center for Lymphocytic Gastritis

Genetic Tests for Lymphocytic Gastritis

Anatomical Context for Lymphocytic Gastritis

MalaCards organs/tissues related to Lymphocytic Gastritis:

40
T Cells, Skin, Liver, B Cells, Testes, Pancreas, Salivary Gland

Publications for Lymphocytic Gastritis

Articles related to Lymphocytic Gastritis:

(show top 50) (show all 183)
# Title Authors PMID Year
1
Topography, morphology, and etiology of lymphocytic gastritis: a single institution experience. 61
31897816 2020
2
Lymphocytic Gastritis Overshadowed by Gastric Mucosa-Associated Lymphoid Tissue Lymphoma. 61
30773956 2019
3
Immune-related acute and lymphocytic gastritis in a patient with metastatic melanoma treated with pembrolizumab immunotherapy. 61
31748755 2019
4
Lymphocytic gastritis in a patient with dyspepsia. 61
31534752 2019
5
Lymphocytic gastritis. 61
31820858 2019
6
Non-malignant Helicobacter pylori-Associated Diseases. 61
31016630 2019
7
Lymphocytic gastritis induced by pembrolizumab in a patient with metastatic melanoma. 61
30256271 2018
8
Associations of Microscopic Colitis With Other Lymphocytic Disorders of the Gastrointestinal Tract. 61
29535059 2018
9
The differential diagnosis of Helicobacter pylori negative gastritis. 61
30255340 2018
10
Subtypes of chronic gastritis in patients with celiac disease before and after gluten-free diet. 61
29026594 2017
11
Recurrent anaemia in a patient with lymphocytic gastritis and vitamin B12 deficiency. 61
28943131 2017
12
Rare Gastric Lesions Associated with Helicobacter pylori Infection: A Histopathological Review. 61
28592787 2017
13
Transverse Myelitis as Manifestation of Celiac Disease in a Toddler. 61
28153851 2017
14
Development of lymphocytic gastritis with recurrent Helicobacter pylori infection. 61
28211221 2017
15
Lymphocytic Gastritis Identified by Abnormal PET Scan. 61
28462239 2017
16
Propionibacterium acnes overabundance and natural killer group 2 member D system activation in corpus-dominant lymphocytic gastritis. 61
27538697 2016
17
The pathological findings seen in laparoscopic sleeve gastrectomies for weight loss. 61
27020497 2016
18
Pathological and Clinical Correlation between Celiac Disease and Helicobacter Pylori Infection; a Review of Controversial Reports. 61
27252814 2016
19
Lymphocytic gastritis: clinical, endoscopic and histopathologic features. 61
27532536 2016
20
Letter: lymphocytic gastritis and coeliac disease. 61
26331558 2015
21
Letter: lymphocytic gastritis and coeliac disease - authors' reply. 61
26331559 2015
22
The coeliac stomach: gastritis in patients with coeliac disease. 61
25973720 2015
23
Collagenous gastritis: a morphologic and immunohistochemical study of 40 patients. 61
25234289 2015
24
Lymphocytic gastritis is not associated with active Helicobacter pylori infection. 61
24826984 2014
25
Gastric adenocarcinoma in common variable immunodeficiency: features of cancer and associated gastritis may be characteristic of the condition. 61
24788529 2014
26
Helicobacter pylori Associated Lymphocytic Gastritis in a Child. 61
25349835 2014
27
Lymphocytic gastritis showing concomitant occurrence of both CD4 + and CD8 + T-cells among epithelial cells. 61
25047508 2014
28
Pathology and differential diagnosis of chronic, noninfectious gastritis. 61
24815937 2014
29
High proportion of granzyme B+ intraepithelial lymphocytes contributes to epithelial apoptosis in Helicobacter pylori-associated lymphocytic gastritis. 61
23356909 2013
30
Iron deficiency anemia due to lymphocytic gastritis with Helicobacter pylori infection in childhood: case report. 61
23528908 2013
31
Endoscopic, ultrasonographic, and pathologic correlation of lymphocytic gastritis. 61
23716104 2013
32
Endoscopic and histological gastric lesions in children with celiac disease: mucosal involvement is not only confined to the duodenum. 61
22773062 2012
33
Diffuse type gastric carcinoma presenting as giant gastric folds: lessons learned from six miss diagnosed cases. 61
22651965 2012
34
Neutrophilic infiltration in gluten-sensitive enteropathy is neither uncommon nor insignificant: assessment of duodenal biopsies from 267 pediatric and adult patients. 61
22531172 2012
35
Severe spruelike enteropathy associated with olmesartan. 61
22728033 2012
36
Gastrointestinal pathology in celiac disease: a case series of 150 consecutive newly diagnosed patients. 61
22706856 2012
37
Hypovitaminosis D as predisposing factor for atrophic type A gastritis: a case-control study and review of the literature on the interaction of Vitamin D with the immune system. 61
21286859 2012
38
Lymphocytic gastritis in pediatric celiac disease. 61
21244234 2011
39
Gastritis in Alaskan racing sled dogs. 61
21247587 2011
40
Gastroduodenal mucosa in microscopic colitis. 61
21291294 2011
41
Clinical presentation and salivary gland histopathology of paediatric primary Sjögren's syndrome. 61
21640054 2011
42
[Functional condition of the stomach, pancreas, liver and gallbladder in celiac disease]. 61
21516844 2011
43
Collagenous gastritis. 61
19103610 2010
44
Helicobacter pylori-negative gastritis: seek, yet ye shall not always find. 61
20631607 2010
45
Endoscopic portrayal of lymphocytic gastritis in a child. 61
20639772 2010
46
Collagenous sprue is not always associated with dismal outcomes: a clinicopathological study of 19 patients. 61
19855376 2010
47
Collagenous sprue: a clinicopathologic study of 12 cases. 61
19641452 2009
48
[Helicobacter pylori infection in children with celiac disease]. 61
20191880 2009
49
Lymphocytic disorders of the gastrointestinal tract: a review for the practicing pathologist. 61
19700939 2009
50
Intraepithelial lymphocytes in duodenum from Brazilian adolescents with type 1 diabetes. Influence of Helicobacter pylori. 61
19017282 2009

Variations for Lymphocytic Gastritis

Expression for Lymphocytic Gastritis

Search GEO for disease gene expression data for Lymphocytic Gastritis.

Pathways for Lymphocytic Gastritis

Pathways related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.06 TGM2 GZMB FASLG FAS ATP4A ATP12A
2
Show member pathways
12.45 GZMB FASLG FAS CD8A
3
Show member pathways
12.13 GZMB FASLG FAS
4 11.97 GZMB FASLG FAS CD8A
5
Show member pathways
11.8 GZMB FASLG FAS
6
Show member pathways
11.49 GZMB FASLG CD8A
7 11.19 TIA1 GZMB FASLG FAS
8 11.1 FASLG FAS
9 11 FASLG FAS
10
Show member pathways
10.92 GZMB FASLG CD8A

GO Terms for Lymphocytic Gastritis

Cellular components related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.02 TOR1A TGM2 FASLG ATP4A ATP12A

Biological processes related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.71 TIA1 GZMB FASLG FAS
2 extrinsic apoptotic signaling pathway GO:0097191 9.48 FASLG FAS
3 potassium ion import across plasma membrane GO:1990573 9.46 ATP4A ATP12A
4 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.43 FASLG FAS
5 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.37 FASLG FAS
6 cellular sodium ion homeostasis GO:0006883 9.32 ATP4A ATP12A
7 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.26 ATP4A ATP12A
8 sodium ion export across plasma membrane GO:0036376 9.16 ATP4A ATP12A
9 cellular potassium ion homeostasis GO:0030007 8.96 ATP4A ATP12A
10 necroptotic signaling pathway GO:0097527 8.62 FASLG FAS

Molecular functions related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Lymphocytic Gastritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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