MCID: LYM015
MIFTS: 31

Lymphocytic Gastritis

Categories: Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Lymphocytic Gastritis

MalaCards integrated aliases for Lymphocytic Gastritis:

Name: Lymphocytic Gastritis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4035
NCIt 50 C27051
UMLS 73 C1283271

Summaries for Lymphocytic Gastritis

MalaCards based summary : Lymphocytic Gastritis is related to collagenous gastritis and gastritis. An important gene associated with Lymphocytic Gastritis is GZMB (Granzyme B), and among its related pathways/superpathways are Allograft rejection and Apoptosis Modulation and Signaling. The drugs Esomeprazole and Proton Pump Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include t cells, thyroid and testis, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Lymphocytic Gastritis

Diseases related to Lymphocytic Gastritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 collagenous gastritis 11.5
2 gastritis 10.7
3 celiac disease 1 10.2
4 helicobacter pylori infection 10.2
5 lymphoma 10.1
6 orbit lymphoma 10.1 GZMB TIA1
7 lichen sclerosus et atrophicus 10.1 GZMB TIA1
8 lymphomatoid granulomatosis 10.1 GZMB TIA1
9 subcutaneous panniculitis-like t-cell lymphoma 10.1 GZMB TIA1
10 primary cutaneous anaplastic large cell lymphoma 10.1 GZMB TIA1
11 composite lymphoma 10.1 GZMB TIA1
12 hepatosplenic t-cell lymphoma 10.1 GZMB TIA1
13 giardiasis 10.1 GZMB TIA1
14 infiltrating lipoma 10.1 GZMB TIA1
15 necrotizing sialometaplasia 10.1 GZMB TIA1
16 ileum cancer 10.0 GZMB TIA1
17 angioimmunoblastic t-cell lymphoma 10.0 GZMB TIA1
18 reticulosarcoma 10.0 GZMB TIA1
19 cowpox 10.0 FAS GZMB
20 gastric lymphoma 10.0
21 adenocarcinoma 10.0
22 peripheral t-cell lymphoma 10.0 GZMB TIA1
23 autoimmune lymphoproliferative syndrome, type v 10.0 FAS TIA1
24 cutaneous t cell lymphoma 10.0 GZMB TIA1
25 breast medullary carcinoma 10.0 FASLG GZMB
26 mycosis fungoides 10.0 GZMB TIA1
27 t-cell large granular lymphocyte leukemia 9.9 FASLG GZMB
28 erythema multiforme 9.9 FASLG GZMB
29 chronic nk-cell lymphocytosis 9.9 B3GAT1 FASLG
30 gastric cancer 9.9
31 gastric adenocarcinoma 9.9
32 acute graft versus host disease 9.9 FASLG GZMB
33 chronic venous leg ulcers 9.9 FAS FASLG
34 type ii mixed cryoglobulinemia 9.9 FAS FASLG
35 viral esophagitis 9.9 B3GAT1 GZMB TIA1
36 natural killer cell leukemia 9.9 B3GAT1 GZMB TIA1
37 autoimmune lymphoproliferative syndrome 9.9 FAS FASLG
38 lymphoproliferative syndrome 9.9 FAS FASLG
39 cartilage-hair hypoplasia 9.9 FAS FASLG
40 acute myocarditis 9.9 FAS FASLG
41 alopecia areata 9.9 FASLG GZMB
42 central nervous system tuberculosis 9.9 FAS FASLG
43 epstein-barr virus-associated gastric carcinoma 9.9 FAS FASLG
44 panniculitis 9.9 FAS GZMB TIA1
45 hemophagocytic lymphohistiocytosis 9.9 FAS GZMB
46 silicosis 9.8 FAS FASLG
47 pneumoconiosis 9.8 FAS FASLG
48 lymphopenia 9.8 FAS FASLG
49 viral hepatitis 9.8 FAS FASLG
50 choriocarcinoma of the testis 9.8 FASLG GZMB TIA1

Graphical network of the top 20 diseases related to Lymphocytic Gastritis:



Diseases related to Lymphocytic Gastritis

Symptoms & Phenotypes for Lymphocytic Gastritis

GenomeRNAi Phenotypes related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.17 FAS GZMB TIA1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.17 FAS FASLG GZMB TIA1

Drugs & Therapeutics for Lymphocytic Gastritis

Drugs for Lymphocytic Gastritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Esomeprazole Approved, Investigational Phase 3 161796-78-7, 119141-88-7 4594 9579578
2 Proton Pump Inhibitors Phase 3
3 Anti-Ulcer Agents Phase 3
4 Antacids Phase 3
5 Gastrointestinal Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Esomeprazole Treatment for Patients With Lymphocytic Gastritis Unknown status NCT00455754 Phase 3 Esomeprazole

Search NIH Clinical Center for Lymphocytic Gastritis

Genetic Tests for Lymphocytic Gastritis

Anatomical Context for Lymphocytic Gastritis

MalaCards organs/tissues related to Lymphocytic Gastritis:

41
T Cells, Thyroid, Testis, B Cells, Nk Cells, Small Intestine

Publications for Lymphocytic Gastritis

Articles related to Lymphocytic Gastritis:

(show top 50) (show all 78)
# Title Authors Year
1
Lymphocytic gastritis induced by pembrolizumab in a patient with metastatic melanoma. ( 30256271 )
2018
2
Lymphocytic Gastritis Identified by Abnormal PET Scan. ( 28462239 )
2017
3
Development of lymphocytic gastritis with recurrent Helicobacter pylori infection. ( 28211221 )
2017
4
Recurrent anaemia in a patient with lymphocytic gastritis and vitamin B12 deficiency. ( 28943131 )
2017
5
Lymphocytic gastritis: clinical, endoscopic and histopathologic features. ( 27532536 )
2016
6
Propionibacterium acnes overabundance and NKG2D system activation in corpus-dominant lymphocytic gastritis. ( 27538697 )
2016
7
Letter: lymphocytic gastritis and coeliac disease. ( 26331558 )
2015
8
Letter: lymphocytic gastritis and coeliac disease - authors' reply. ( 26331559 )
2015
9
Lymphocytic gastritis is not associated with active Helicobacter pylori infection. ( 24826984 )
2014
10
Lymphocytic gastritis showing concomitant occurrence of both CD4 + and CD8 + T-cells among epithelial cells. ( 25047508 )
2014
11
Helicobacter pylori Associated Lymphocytic Gastritis in a Child. ( 25349835 )
2014
12
Pathology in practice. Severe gastric submucosal edema, with vasculitis, fibrinoid degeneration, and mild eosinophilic and lymphocytic gastritis. ( 24649989 )
2014
13
Endoscopic, ultrasonographic, and pathologic correlation of lymphocytic gastritis. ( 23716104 )
2013
14
High proportion of granzyme B+ intraepithelial lymphocytes contributes to epithelial apoptosis in Helicobacter pylori-associated lymphocytic gastritis. ( 23356909 )
2013
15
Iron deficiency anemia due to lymphocytic gastritis with Helicobacter pylori infection in childhood: case report. ( 23528908 )
2013
16
Lymphocytic gastritis in pediatric celiac disease. ( 21244234 )
2011
17
Endoscopic portrayal of lymphocytic gastritis in a child. ( 20639772 )
2010
18
Lymphocytic gastritis and celiac disease in indian children: evidence of a positive relation. ( 18979579 )
2008
19
The frequency of lymphocytic gastritis in baboons. ( 18396790 )
2008
20
The immunohistochemistry profile of lymphocytic gastritis in celiac disease and helicobacter pylori infection: interplay between infection and inflammation. ( 18274643 )
2007
21
Healing of lymphocytic gastritis after Helicobacter pylori eradication therapy--a randomized, double-blind, placebo-controlled multicentre trial. ( 16441467 )
2006
22
Lymphocytic gastritis in Helicobacter pylori-positive gastric MALT lymphoma--report of two cases. ( 15908769 )
2005
23
Lymphocytic gastritis-like T cell lymphoma: molecular evidence of an unusual recurrence. ( 15509690 )
2004
24
Lymphocytic gastritis in pediatric celiac disease -- immunohistochemical study of the intraepithelial lymphocytic component. ( 14704635 )
2004
25
Resolution of gastrointestinal protein loss after Helicobacter pylori eradication in a patient with hypertrophic lymphocytic gastritis. ( 15610076 )
2004
26
Epithelial cell proliferation and glandular atrophy in lymphocytic gastritis: effect of H pylori treatment. ( 14669318 )
2003
27
Treatment of Helicobacter pylori in patients with lymphocytic gastritis. ( 11490827 )
2001
28
Clinical and endoscopic improvement of lymphocytic gastritis with eradication of Helicobacter pylori. ( 11474405 )
2001
29
Collagenous gastritis associated with lymphocytic gastritis and celiac disease. ( 11735694 )
2001
30
Healing of lymphocytic gastritis by eradication of Helicobacter pylori. ( 11173895 )
2001
31
Lymphocytic gastritis and protein-losing gastropathy. ( 11030189 )
2000
32
Lymphocytic gastritis and Helicobacter pylori: reluctant mucosal partners? ( 11179991 )
2000
33
Superficial gastric carcinoma developed on localized hypertrophic lymphocytic gastritis: a variant of localized Ménétrier's disease? ( 10707370 )
2000
34
Lymphocytic gastritis: association with etiology and topology. ( 9989841 )
1999
35
Lymphocytic gastritis, Helicobacter pylori, and gastric cancer: is vitamin C the common link? ( 10355855 )
1999
36
Effects of Helicobacter pylori eradication on the natural history of lymphocytic gastritis. ( 10486354 )
1999
37
The pattern of involvement of the gastric mucosa in lymphocytic gastritis is predictive of the presence of duodenal pathology. ( 10690170 )
1999
38
Lymphocytic gastritis and coeliac disease: evidence of a positive association. ( 9659261 )
1998
39
Lymphocytic gastritis: a study of its frequency and review of the literature. ( 9711310 )
1998
40
Lymphocytic gastritis resembling graft-vs.-host disease following autologous hematopoietic cell transplantation. ( 9701391 )
1998
41
High proportion of granzyme B-positive (activated) intraepithelial and lamina propria lymphocytes in lymphocytic gastritis. ( 9537473 )
1998
42
Adenocarcinoma of the small bowel, coeliac disease, and lymphocytic gastritis. ( 10193339 )
1998
43
Hypertrophic lymphocytic gastritis with a gastric carcinoma. ( 9831277 )
1998
44
Spontaneous remission of hypertrophic lymphocytic gastritis associated with hypoproteinemia. ( 9932632 )
1998
45
Lymphocytic gastritis and Helicobacter pylori: a Brazilian survey. ( 9577382 )
1998
46
Diagnostic criteria in lymphocytic gastritis. ( 9098036 )
1997
47
Successful treatment of protein-losing lymphocytic gastritis with omeprazole. ( 9451692 )
1997
48
Massive bleeding from multiple gastric ulcerations in a patient with lymphocytic gastritis and celiac sprue. ( 9412920 )
1997
49
Association of Helicobacter pylori infection, lymphoid follicles, and lymphocytic gastritis: a risk factor for the development of primary gastric lymphoma? ( 8707131 )
1996
50
Lymphocytic gastritis and coeliac disease. ( 8707101 )
1996

Variations for Lymphocytic Gastritis

Expression for Lymphocytic Gastritis

Search GEO for disease gene expression data for Lymphocytic Gastritis.

Pathways for Lymphocytic Gastritis

Pathways related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.44 FAS FASLG GZMB
2
Show member pathways
12.35 FAS FASLG GZMB
3 12.06 FAS FASLG GZMB
4
Show member pathways
11.91 FAS FASLG GZMB
5
Show member pathways
11.79 FAS FASLG GZMB
6
Show member pathways
11.59 FASLG GZMB
7
Show member pathways
11.43 FAS FASLG
8
Show member pathways
11.39 FAS FASLG GZMB
9 11.36 FAS FASLG
10
Show member pathways
11.24 FASLG GZMB
11 11.19 FAS FASLG GZMB TIA1
12 11.14 FAS FASLG
13 11.05 FAS FASLG
14 10.87 FAS FASLG

GO Terms for Lymphocytic Gastritis

Biological processes related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.4 FAS FASLG
2 apoptotic signaling pathway GO:0097190 9.37 FAS FASLG
3 extrinsic apoptotic signaling pathway GO:0097191 9.32 FAS FASLG
4 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.26 FAS FASLG
5 apoptotic process GO:0006915 9.26 FAS FASLG GZMB TIA1
6 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.16 FAS FASLG
7 necroptotic signaling pathway GO:0097527 8.62 FAS FASLG

Sources for Lymphocytic Gastritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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