LH
MCID: LYM043
MIFTS: 31

Lymphocytic Hypophysitis (LH)

Categories: Endocrine diseases, Eye diseases, Immune diseases, Rare diseases

Aliases & Classifications for Lymphocytic Hypophysitis

MalaCards integrated aliases for Lymphocytic Hypophysitis:

Name: Lymphocytic Hypophysitis 20
Autoimmune Hypophysitis 20 70
Lymphocytic Hypopituitarism 70
Lyh 20
Lh 20

Classifications:



External Ids:

UMLS 70 C0271560 C0342410

Summaries for Lymphocytic Hypophysitis

GARD : 20 Lymphocytic hypophysitis (LH) is a condition in which the pituitary gland becomes infiltrated by lymphocytes, resulting in pituitary enlargement and impaired function. It most often occurs in women in late pregnancy or the postpartum period, but can also occur in prepubertal or post-menopausal women, and in men. Symptoms of LH may include headache, visual field impairment and more rarely, double vision (diplopia). The exact cause is unknown but is thought to be autoimmune-related. Although some cases resolve on their own or after a short course of steroids, other cases cause persistent problems even with aggressive medical or surgical treatment.

MalaCards based summary : Lymphocytic Hypophysitis, also known as autoimmune hypophysitis, is related to diabetes insipidus and pituitary adenoma. An important gene associated with Lymphocytic Hypophysitis is ENO1 (Enolase 1), and among its related pathways/superpathways are Glycosaminoglycan metabolism and Glucose metabolism. Affiliated tissues include pituitary, eye and lung.

Wikipedia : 73 Autoimmune hypophysitis is defined as inflammation of the pituitary gland due to... more...

Related Diseases for Lymphocytic Hypophysitis

Diseases related to Lymphocytic Hypophysitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 diabetes insipidus 30.8 POMC GH1
2 pituitary adenoma 30.7 POMC GH1
3 hypopituitarism 30.6 TBX19 POMC GH1
4 pituitary hormone deficiency, combined, 2 30.5 POMC GH1
5 adenohypophysitis 30.4 POMC GH1
6 hyperprolactinemia 30.2 POMC GH1
7 pituitary tumors 30.1 POMC GH1
8 pituitary apoplexy 30.1 POMC GH1
9 pituitary gland disease 30.1 TBX19 POMC GH1
10 acth deficiency, isolated 29.8 TBX19 POMC
11 pituitary adenoma, prolactin-secreting 29.6 POMC GH1
12 hypothyroidism, congenital, nongoitrous, 4 29.6 POMC GH1
13 hyperthyroidism 29.6 POMC GH1
14 empty sella syndrome 29.5 POMC GH1
15 acromegaly 29.5 POMC GH1
16 functioning pituitary adenoma 29.2 TBX19 POMC GH1
17 autoimmune disease 10.5
18 thyroiditis 10.5
19 amenorrhea 10.5
20 adenoma 10.5
21 hypothyroidism 10.4
22 primary hypophysitis 10.4
23 hypogonadism 10.4
24 germinoma 10.4
25 headache 10.4
26 galactorrhea 10.3
27 hashimoto thyroiditis 10.2
28 optic neuritis 10.2
29 aseptic meningitis 10.2
30 neuritis 10.2
31 carotid artery occlusion 10.2
32 hypoglycemia 10.2
33 central congenital hypothyroidism 10.2
34 panhypophysitis 10.2
35 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1
36 hypogonadotropic hypogonadism 10.1
37 graves' disease 10.1
38 meningitis 10.1
39 dacryoadenitis 10.1
40 infundibulo-neurohypophysitis 10.1
41 autoimmune retinopathy 10.1 ENO2 ENO1
42 skin granular cell tumor 10.1 ENO2 ENO1
43 cancer-associated retinopathy 10.1 ENO2 ENO1
44 systemic lupus erythematosus 10.1
45 sarcoidosis 1 10.1
46 meningoencephalitis 10.1
47 facial paralysis 10.1
48 impotence 10.1
49 craniopharyngioma 10.1
50 lupus erythematosus 10.1

Graphical network of the top 20 diseases related to Lymphocytic Hypophysitis:



Diseases related to Lymphocytic Hypophysitis

Symptoms & Phenotypes for Lymphocytic Hypophysitis

Drugs & Therapeutics for Lymphocytic Hypophysitis

Search Clinical Trials , NIH Clinical Center for Lymphocytic Hypophysitis

Genetic Tests for Lymphocytic Hypophysitis

Anatomical Context for Lymphocytic Hypophysitis

MalaCards organs/tissues related to Lymphocytic Hypophysitis:

40
Pituitary, Eye, Lung, Hypothalamus, Thyroid, Placenta, Thymus

Publications for Lymphocytic Hypophysitis

Articles related to Lymphocytic Hypophysitis:

(show top 50) (show all 550)
# Title Authors PMID Year
1
Diabetes insipidus secondary to sellar/parasellar lesions. 61
33769630 2021
2
Pituitary disease and pregnancy. 61
33358152 2021
3
Early pulse glucocorticoid therapy and improved hormonal outcomes in primary hypophysitis. 61
33744880 2021
4
Magnetic resonance imaging criteria of immune checkpoint inhibitor-induced hypophysitis. 61
32888700 2021
5
Hypothalamic-Pituitary Dysfunction - Part 2: Hypothalamic-Pituitary Dysfunctions Other Than Growth Hormone Deficiency in Cancer Survivors. 61
33556939 2021
6
A case of isolated hypothalamitis with a literature review and a comparison with autoimmune hypophysitis. 61
32963149 2021
7
Autoimmune Hypophysitis in Systemic Lupus Erythematosus. 61
33452786 2021
8
Hypothalamitis: A Novel Autoimmune Endocrine Disease. A Literature Review and Case Report. 61
33104773 2021
9
Primary hypophysitis: Experience of a Single Tertiary Center. 61
31234218 2021
10
Postpartum headache: A broader differential. 61
32718737 2021
11
Neuropathology of Pituitary Adenomas and Sellar Lesions. 61
33476394 2021
12
Markers of humoral and cell-mediated immune response in primary autoimmune hypophysitis: a pilot study. 61
33484410 2021
13
[Clinical aspects of pregnancy-related lymphocytic hypophysitis]. 61
33202493 2020
14
Masked type 1 diabetes mellitus (T1DM) unveiled by glucocorticoid replacement: a case of simultaneous development of T1DM and hypophysitis in an elderly woman. 61
32669510 2020
15
Autoimmune hypophysitis secondary to therapy with immune checkpoint inhibitors: Four cases describing the clinical heterogeneity of central endocrine dysfunction. 61
32164491 2020
16
Clinical and pathological features of 124 patients with indistinguishable sellar lesions and central diabetes insipidus. 61
33099348 2020
17
Now You See, Now You Don't: A Case Of Spontaneous Regression of Pituitary Tumour. 61
32802610 2020
18
Remission of Pituitary Autoimmunity Induced by Gluten-Free Diet in Patients With Celiac Disease. 61
32433771 2020
19
Infiltrative lymphocytic hypophysitis successfully treated with rituximab and mycophenolate mofetil. 61
32729848 2020
20
Role of 18F-fluorodeoxyglucose (FDG) and 18F-2-fluorodeoxy sorbitol (FDS) in autoimmune hypophysitis: a case report. 61
32517690 2020
21
MECHANISMS IN ENDOCRINOLOGY: Autoimmune hypopituitarism: novel mechanistic insights. 61
31999621 2020
22
Clinical Characteristics, Management, and Treatment Outcomes of Primary Hypophysitis: A Monocentric Cohort. 61
32268423 2020
23
Presence of CD3+ and CD79a+ Lymphocytes in the Pituitary Gland of Dogs at Post-mortem Examination. 61
32359623 2020
24
Lymphocytic Hypophysitis Presenting as Bilateral Abducens Nerve Palsy: A Case Report. 61
32395162 2020
25
Targeting PD-L1 Initiates Effective Antitumor Immunity in a Murine Model of Cushing Disease. 61
31744830 2020
26
Clinical aspects of autoimmune hypothalamitis, a variant of autoimmune hypophysitis: Experience from one center. 61
31779500 2020
27
[Primary lymphocytic hypophysitis. Report of one case]. 61
32730504 2020
28
Autoimmune Hypophysitis With Systemic Lupus Erythematosus: A Case Report and Literature Review. 61
33117291 2020
29
Case Report: Ipilimumab-Induced Panhypophysitis: An Infrequent Occurrence and Literature Review. 61
33335854 2020
30
Intracranial Germinoma Masquerading as Secondary Granulomatous Hypophysitis: A Case Report and Review of Literature. 61
31269501 2020
31
Autoimmune hypophysitis and viral infection in a pregnant woman: a challengeable case. 61
32774605 2020
32
Parasellar T2 dark sign on magnetic resonance imaging to differentiate lymphocytic hypophysitis from pituitary adenoma. 61
32874742 2020
33
Hypophysitis (Including IgG4 and Immunotherapy). 61
32126548 2020
34
Giant cell myocarditis with central diabetes insipidus: A case report. 61
31933698 2020
35
NMDA Receptor Encephalitis with Concurrent Autoimmune Hypophysitis Presented with Acute Psychosis. 61
33173563 2020
36
Radiological and hormonal improvements in a 22-year-old patient with lymphocytic hypophysitis - the watchful waiting approach. 61
31681974 2020
37
[A case of lymphocytic hypophysitis presenting as spontaneous resolution of a pituitary mass]. 61
31887839 2020
38
Hypophysitis: An update on the novel forms, diagnosis and management of disorders of pituitary inflammation. 61
31866206 2019
39
Isolated Langerhans cell histiocytosis in the hypothalamic-pituitary region: a case report. 61
31856773 2019
40
Autoimmune phenomena involving the pituitary gland in children: New developing data about diagnosis and treatment. 61
31401342 2019
41
Machine learning defined diagnostic criteria for differentiating pituitary metastasis from autoimmune hypophysitis in patients undergoing immune checkpoint blockade therapy. 61
31415986 2019
42
Infundibuloneurohypophysitis associated with autoimmune thrombocytopenia and chiasmal syndrome: a case report. 61
30128677 2019
43
Disease heterogeneity in IgG4-related hypophysitis: report of two histopathologically proven cases and review of the literature. 61
30911814 2019
44
Other Pituitary Conditions and Pregnancy. 61
31345525 2019
45
Clinical Features, Magnetic Resonance Imaging, and Treatment Experience of 20 Patients with Lymphocytic Hypophysitis in a Single Center. 61
30790734 2019
46
Severe hypoglycemia and hyponatremia caused by hypopituitarism in a female patient with type 1 diabetes: A case report. 61
31305453 2019
47
Idiopathic and isolated adrenocorticotropic hormone deficiency presenting as continuous epigastric discomfort without symptoms of hypoglycemia: a case report. 61
31036085 2019
48
A case of severe rhabdomyolysis associated with secondary adrenal insufficiency and autoimmune hepatitis. 61
30898957 2019
49
A rare cause of postpartum acute hyponatremia. 61
30875679 2019
50
IgG4-related intracranial disease. 61
30320530 2019

Variations for Lymphocytic Hypophysitis

Expression for Lymphocytic Hypophysitis

Search GEO for disease gene expression data for Lymphocytic Hypophysitis.

Pathways for Lymphocytic Hypophysitis

Pathways related to Lymphocytic Hypophysitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.25 ENO3 ENO2 ENO1
2
Show member pathways
12.07 ENO3 ENO2 ENO1
3
Show member pathways
11.66 ENO3 ENO2 ENO1
4
Show member pathways
11.42 ENO3 ENO2 ENO1
5 11.34 TBX19 POMC
6 10.84 ENO3 ENO2 ENO1

GO Terms for Lymphocytic Hypophysitis

Cellular components related to Lymphocytic Hypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 POMC GH1 ENO3 ENO2 ENO1
2 phosphopyruvate hydratase complex GO:0000015 8.8 ENO3 ENO2 ENO1

Biological processes related to Lymphocytic Hypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gluconeogenesis GO:0006094 9.43 ENO3 ENO2 ENO1
2 glycolytic process GO:0006096 9.33 ENO3 ENO2 ENO1
3 canonical glycolysis GO:0061621 9.13 ENO3 ENO2 ENO1
4 regulation of vacuole fusion, non-autophagic GO:0032889 8.8 ENO3 ENO2 ENO1

Molecular functions related to Lymphocytic Hypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 magnesium ion binding GO:0000287 9.33 ENO3 ENO2 ENO1
2 hormone activity GO:0005179 9.26 POMC GH1
3 lyase activity GO:0016829 9.13 ENO3 ENO2 ENO1
4 phosphopyruvate hydratase activity GO:0004634 8.8 ENO3 ENO2 ENO1

Sources for Lymphocytic Hypophysitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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