LH
MCID: LYM043
MIFTS: 38

Lymphocytic Hypophysitis (LH)

Categories: Endocrine diseases, Eye diseases, Immune diseases, Rare diseases

Aliases & Classifications for Lymphocytic Hypophysitis

MalaCards integrated aliases for Lymphocytic Hypophysitis:

Name: Lymphocytic Hypophysitis 53
Autoimmune Hypophysitis 53 73
Lymphocytic Hypopituitarism 73
Lyh 53
Lh 53

Classifications:



External Ids:

Summaries for Lymphocytic Hypophysitis

NIH Rare Diseases : 53 Lymphocytic hypophysitis (LH) is a condition in which the pituitary gland becomes infiltrated by lymphocytes, resulting in pituitary enlargement and impaired function. It most often occurs in women in late pregnancy or the postpartum period, but can also occur in prepubertal or post-menopausal women, and in men. Symptoms of LH may include headache, visual field impairment and more rarely, double vision (diplopia). The exact cause is unknown but is thought to be autoimmune-related. Although some cases resolve on their own or after a short course of steroids, other cases cause persistent problems even with aggressive medical or surgical treatment.

MalaCards based summary : Lymphocytic Hypophysitis, also known as autoimmune hypophysitis, is related to hypopituitarism and acth deficiency, isolated. An important gene associated with Lymphocytic Hypophysitis is ENO1 (Enolase 1), and among its related pathways/superpathways are Glycosaminoglycan metabolism and Glucose metabolism. The drug Pembrolizumab has been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Autoimmune hypophysitis or lymphocytic hypophysitis is defined as inflammation of the pituitary gland... more...

Related Diseases for Lymphocytic Hypophysitis

Diseases related to Lymphocytic Hypophysitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 198)
# Related Disease Score Top Affiliating Genes
1 hypopituitarism 30.4 GH1 POMC
2 acth deficiency, isolated 29.8 POMC TBX19
3 gonadal disease 29.8 GH1 POMC
4 pituitary tumors 29.8 GH1 POMC
5 adenohypophysitis 29.7 GH1 POMC
6 functioning pituitary adenoma 29.7 GH1 POMC
7 pituitary hormone deficiency, combined, 2 29.6 GH1 POMC
8 hyperprolactinemia 29.6 GH1 POMC
9 pituitary adenoma, prolactin-secreting 29.6 GH1 POMC
10 conn's syndrome 29.6 GH1 POMC
11 acromegaly 29.6 GH1 POMC
12 chromophobe adenoma 29.5 GH1 POMC
13 anorexia nervosa 29.4 GH1 POMC
14 leydig cell hypoplasia 12.1
15 resistance to lh 12.1
16 male pseudohermaphroditism due to defective lh molecule 12.1
17 leydig cell hypoplasia, type i 12.0
18 acth-independent macronodular adrenal hyperplasia 11.2
19 hypogonadotropic hypogonadism 23 without anosmia 11.2
20 adrenal hypoplasia, congenital, with absent pituitary luteinizing hormone 11.0
21 laugier-hunziker syndrome 11.0
22 bangstad syndrome 11.0
23 ovarian dysgenesis 1 11.0
24 progesterone resistance 11.0
25 pituitary hormone deficiency, combined, 1 11.0
26 crandall syndrome 11.0
27 polycystic ovary syndrome 10.5
28 diabetes insipidus 10.4
29 hypogonadotropic hypogonadism 10.4
30 hypogonadism 10.4
31 precocious puberty 10.4
32 ventricular fibrillation, paroxysmal familial, 1 10.3
33 adenoma 10.3
34 anovulation 10.3
35 central precocious puberty 10.3
36 ovarian disease 10.2
37 pituitary adenoma 10.2
38 childhood absence epilepsy 10.2
39 melanoma 10.1
40 autoimmune retinopathy 10.1 ENO1 ENO2
41 prostate cancer 10.1
42 gonadal dysgenesis 10.1
43 infertility 10.1
44 cancer-associated retinopathy 10.1 ENO1 ENO2
45 pituitary apoplexy 10.1
46 thyroiditis 10.1
47 brain injury 10.1 ENO1 ENO2
48 lung oat cell carcinoma 10.1 ENO2 POMC
49 bronchus cancer 10.1 ENO2 POMC
50 acute thyroiditis 10.1 ENO2 POMC

Graphical network of the top 20 diseases related to Lymphocytic Hypophysitis:



Diseases related to Lymphocytic Hypophysitis

Symptoms & Phenotypes for Lymphocytic Hypophysitis

GenomeRNAi Phenotypes related to Lymphocytic Hypophysitis according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.53 GH1 POMC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.53 POMC
3 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.53 GH1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.53 POMC
5 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.53 GH1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.53 GH1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.53 GH1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.53 GH1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.53 GH1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.53 POMC
11 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.53 POMC
12 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.53 GH1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.53 POMC
14 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.53 POMC
15 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.53 GH1

Drugs & Therapeutics for Lymphocytic Hypophysitis

Drugs for Lymphocytic Hypophysitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pembrolizumab Approved Phase 1, Phase 2 1374853-91-4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 MK-3475 in Combination With MRI-guided Laser Ablation in Recurrent Malignant Gliomas Recruiting NCT02311582 Phase 1, Phase 2

Search NIH Clinical Center for Lymphocytic Hypophysitis

Genetic Tests for Lymphocytic Hypophysitis

Anatomical Context for Lymphocytic Hypophysitis

MalaCards organs/tissues related to Lymphocytic Hypophysitis:

41
Pituitary, Thyroid, Eye, Lung, Brain, Kidney, Bone

Publications for Lymphocytic Hypophysitis

Articles related to Lymphocytic Hypophysitis:

(show top 50) (show all 257)
# Title Authors Year
1
Immunotherapy-induced autoimmune hypophysitis. ( 28825378 )
2019
2
Lymphocytic Hypophysitis Secondary to Ruptured Rathke Cleft Cyst: Case Report and Literature Review. ( 29572168 )
2018
3
Neuro-radiological features can predict hypopituitarism in primary autoimmune hypophysitis. ( 29752700 )
2018
4
Diagnosis and management of lymphocytic hypophysitis: A synopsis on current perspective. ( 29547162 )
2018
5
Mycophenolate mofetil treatment in a patient with recurrent lymphocytic hypophysitis. ( 29306856 )
2018
6
Diabetes insipidus is an unfavorable prognostic factor for response to glucocorticoids in patients with autoimmune hypophysitis. ( 29141992 )
2018
7
Lymphocytic hypophysitis associated with Behcet's disease: A case report and review of the literature. ( 29803206 )
2018
8
Corticosteroids in the management of lymphocytic hypophysitis: Case series. ( 29547161 )
2018
9
Spontaneous pregnancy after full recovery from hypopituitarism caused by lymphocytic hypophysitis. ( 30083350 )
2018
10
Cystic Lymphocytic Hypophysitis Mimicking Pituitary Apoplexy: Daunting Challenge. ( 29981909 )
2018
11
Physiological pituitary hyperplasia misinterpreted and treated as lymphocytic hypophysitis. ( 30139788 )
2018
12
Autoimmune hypophysitis. ( 29413466 )
2018
13
Human leucocyte antigens coeliac haplotypes and primary autoimmune hypophysitis in caucasian patients. ( 29418012 )
2018
14
Primary lymphocytic hypophysitis: Clinical characteristics and treatment of 50 cases in a single centre in China over 18A years. ( 28423475 )
2017
15
Diabetes insipidus is an unfavorable prognostic factor for response to glucocorticoids in patients with autoimmune hypophysitis. ( 28626085 )
2017
16
Occurrence of primary lymphocytic hypophysitis in two horses and presence of scattered T-lymphocytes in the normal equine pituitary gland. ( 27852816 )
2017
17
Lymphocytic Hypophysitis Mimicking Pituitary Macroadenoma. ( 28527171 )
2017
18
Lymphocytic Hypophysitis Successfully Treated with Stereotactic Radiosurgery: Case Report and Review of the Literature. ( 28743133 )
2017
19
Case of metastatic uveal melanoma in which an antitumor effect appeared after ipilimumab discontinuation due to autoimmune hypophysitis. ( 27864834 )
2017
20
An Overview of Diagnosis of Primary Autoimmune Hypophysitis in a Prospective Single-Center Experience. ( 27165294 )
2017
21
In Situ Activation of Pituitary-Infiltrating T Lymphocytes in Autoimmune Hypophysitis. ( 28262761 )
2017
22
Autoimmune Hypophysitis Presenting as Solid-Cystic Mass Managed Conservatively. ( 29662575 )
2017
23
Lymphocytic hypophysitis: modern day management with limited role for surgery. ( 27778295 )
2016
24
VARIATIONS IN CLINICAL AND IMAGING FINDINGS BY TIME OF DIAGNOSIS IN FEMALES WITH HYPOPITUITARISM ATTRIBUTED TO LYMPHOCYTIC HYPOPHYSITIS. ( 26595515 )
2016
25
Clinical profile of lymphocytic hypophysitis. ( 27728211 )
2016
26
A study of primary hypophysitis, i.e., two cases of lymphocytic hypophysitis and one IgG4-related variant: The importance of measuring serum IgG4 levels to allow early diagnosis and prompt treatment for the IgG4-related variant. ( 27375049 )
2016
27
Lymphocytic hypophysitis in nonpregnant middle-aged females mimicking pituitary adenoma. ( 26732199 )
2016
28
Management of lymphocytic hypophysitis. ( 26963662 )
2016
29
A primer on pituitary injury for the obstetrician gynecologist: Simmonds disease, Sheehan's syndrome, Traumatic injury, Dahan' s syndrome, Pituitary Apoplexy and Lymphocytic Hypophysitis. ( 27405776 )
2016
30
Cerebral Vasospasm Following Transsphenoidal Hypophysectomy in the Treatment of Lymphocytic Hypophysitis. ( 27244208 )
2016
31
Lymphocytic hypophysitis: An unusual etiology of a usual presentation. ( 27728188 )
2016
32
Granulomatous and lymphocytic hypophysitis - are they immunologically distinct? ( 27704605 )
2016
33
Revisitation of autoimmune hypophysitis: knowledge and uncertainties on pathophysiological and clinical aspects. ( 27503372 )
2016
34
HLA Markers DQ8 and DR53 Are Associated With Lymphocytic Hypophysitis and May Aid in Differential Diagnosis. ( 26317559 )
2015
35
Lymphocytic hypophysitis in the elderly. ( 26094558 )
2015
36
Clinical course of IgG4-related hypophysitis presenting with focal seizure and relapsing lymphocytic hypophysitis. ( 26510826 )
2015
37
LYMPHOCYTIC HYPOPHYSITIS: A RARE AUTOIMMUNE DISORDER PRESENT IN A LARGE SUPRA SELLAR MASS HAVING COMPLETE RESOLUTION WITH STEROIDS. ( 26411146 )
2015
38
Primary (autoimmune) hypophysitis: a single centre experience. ( 24375060 )
2015
39
Anticytotoxic T-lymphocyte antigen-4 induced autoimmune hypophysitis: a case report and literature review. ( 25694832 )
2015
40
Early recognition of ipilimumab-related autoimmune hypophysitis in patients with metastatic melanoma: Case studies and recommendations for management. ( 25855890 )
2015
41
A rare case of autoimmune hypophysitis presenting as temperature dysregulation. ( 25859485 )
2015
42
Rapid conversion of autoimmune hypophysitis to an empty sella with immediate lowering of the serum IgG4 level. Case Report. ( 26071576 )
2015
43
Ipilimumab-Induced Autoimmune Hypophysitis: Diagnostic and Management Challenges Illustrated by a Clinical Case. ( 27265913 )
2015
44
Autoimmune lymphocytic hypophysitis in association with autoimmune eye disease and sequential treatment with infliximab and rituximab. ( 25224140 )
2014
45
Lymphocytic hypophysitis associated with pediatric multiple sclerosis. ( 25266625 )
2014
46
A Protracted and Aggressive Variant of Lymphocytic Hypophysitis with Mammillary Body Involvement and Cognitive Dysfunction. ( 25100390 )
2014
47
Lymphocytic hypophysitis in non-pregnant middle-aged females mimicking pituitary adenoma: A report of two cases. ( 25370565 )
2014
48
Hypopituitarism possibly due to lymphocytic hypophysitis in a patient with type 1 diabetes. ( 25175130 )
2014
49
Diagnosis and classification of autoimmune hypophysitis. ( 24434361 )
2014
50
Autoimmune hypophysitis: new developments. ( 25248604 )
2014

Variations for Lymphocytic Hypophysitis

Expression for Lymphocytic Hypophysitis

Search GEO for disease gene expression data for Lymphocytic Hypophysitis.

Pathways for Lymphocytic Hypophysitis

GO Terms for Lymphocytic Hypophysitis

Cellular components related to Lymphocytic Hypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 ENO1 ENO2 ENO3 GH1 POMC
2 phosphopyruvate hydratase complex GO:0000015 8.8 ENO1 ENO2 ENO3

Biological processes related to Lymphocytic Hypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gluconeogenesis GO:0006094 9.33 ENO1 ENO2 ENO3
2 glycolytic process GO:0006096 9.13 ENO1 ENO2 ENO3
3 canonical glycolysis GO:0061621 8.8 ENO1 ENO2 ENO3

Molecular functions related to Lymphocytic Hypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 magnesium ion binding GO:0000287 9.33 ENO1 ENO2 ENO3
2 hormone activity GO:0005179 9.26 GH1 POMC
3 lyase activity GO:0016829 9.13 ENO1 ENO2 ENO3
4 phosphopyruvate hydratase activity GO:0004634 8.8 ENO1 ENO2 ENO3

Sources for Lymphocytic Hypophysitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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