MCID: LYM043
MIFTS: 37

Lymphocytic Hypophysitis

Categories: Rare diseases, Immune diseases

Aliases & Classifications for Lymphocytic Hypophysitis

MalaCards integrated aliases for Lymphocytic Hypophysitis:

Name: Lymphocytic Hypophysitis 53
Autoimmune Hypophysitis 53 73
Lymphocytic Hypopituitarism 73
Lyh 53
Lh 53

Classifications:



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Summaries for Lymphocytic Hypophysitis

NIH Rare Diseases : 53 Lymphocytic hypophysitis (LH) is a condition in which the pituitary gland becomes infiltrated by lymphocytes, resulting in pituitary enlargement and impaired function. It most often occurs in women in late pregnancy or the postpartum period, but can also occur in prepubertal or post-menopausal women, and in men. Symptoms of LH may include headache, visual field impairment and more rarely, double vision (diplopia). The exact cause is unknown but is thought to be autoimmune-related. Although some cases resolve on their own or after a short course of steroids, other cases cause persistent problems even with aggressive medical or surgical treatment.

MalaCards based summary : Lymphocytic Hypophysitis, also known as autoimmune hypophysitis, is related to hypopituitarism and pituitary tumors. An important gene associated with Lymphocytic Hypophysitis is ENO1 (Enolase 1), and among its related pathways/superpathways are Glycosaminoglycan metabolism and Glucose metabolism. The drug Pembrolizumab has been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Autoimmune hypophysitis or Lymphocytic hypophysitis is defined as inflammation of the pituitary gland... more...

Related Diseases for Lymphocytic Hypophysitis

Diseases related to Lymphocytic Hypophysitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 hypopituitarism 30.0 GH1 POMC
2 pituitary tumors 29.8 GH1 POMC
3 adenohypophysitis 29.7 GH1 POMC
4 functioning pituitary adenoma 29.6 GH1 POMC
5 hyperprolactinemia 29.4 GH1 POMC
6 acth deficiency, isolated 29.3 POMC TBX19
7 acromegaly 29.1 GH1 POMC
8 leydig cell hypoplasia 12.0
9 resistance to lh 11.9
10 male pseudohermaphroditism due to defective lh molecule 11.9
11 leydig cell hypoplasia, type i 11.9
12 hypogonadotropic hypogonadism 23 without anosmia 11.0
13 acth-independent macronodular adrenal hyperplasia 11.0
14 laugier-hunziker syndrome 10.9
15 adrenal hypoplasia, congenital, with absent pituitary luteinizing hormone 10.9
16 ovarian dysgenesis 1 10.9
17 progesterone resistance 10.9
18 pituitary hormone deficiency, combined, 1 10.9
19 bangstad syndrome 10.9
20 crandall syndrome 10.9
21 autoimmune retinopathy 10.3 ENO1 ENO2
22 diabetes insipidus 10.3
23 polycystic ovary syndrome 10.3
24 cancer-associated retinopathy 10.2 ENO1 ENO2
25 prostatitis 10.2
26 brain injury 10.2 ENO1 ENO2
27 precocious puberty 10.2
28 hypogonadism 10.2
29 adenoma 10.2
30 anovulation 10.1
31 hypothalamic disease 10.1 GH1 POMC
32 pituitary adenoma 10.1
33 empty sella syndrome 10.1 GH1 POMC
34 hypoadrenalism 10.1 GH1 POMC
35 hyperpituitarism 10.1 GH1 POMC
36 hypothyroidism, congenital, nongoitrous, 4 10.1 GH1 POMC
37 thyroiditis 10.1
38 acute thyroiditis 10.0 ENO2 POMC
39 chromophobe adenoma 10.0 GH1 POMC
40 pituitary hormone deficiency, combined, 2 10.0 GH1 POMC
41 adrenal gland hyperfunction 10.0 GH1 POMC
42 cervix small cell carcinoma 10.0 ENO2 POMC
43 cloacogenic carcinoma 10.0 ENO2 POMC
44 pituitary gland disease 9.9 GH1 POMC
45 gonadal disease 9.9 GH1 POMC
46 pituitary apoplexy 9.9
47 aging 9.9
48 dacryoadenitis 9.9
49 organ system benign neoplasm 9.9 ENO2 POMC
50 melanoma 9.9

Graphical network of the top 20 diseases related to Lymphocytic Hypophysitis:



Diseases related to Lymphocytic Hypophysitis

Symptoms & Phenotypes for Lymphocytic Hypophysitis

GenomeRNAi Phenotypes related to Lymphocytic Hypophysitis according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.53 GH1 POMC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.53 POMC
3 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.53 GH1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.53 POMC
5 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.53 GH1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.53 GH1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.53 GH1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.53 GH1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.53 GH1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.53 POMC
11 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.53 POMC
12 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.53 GH1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.53 POMC
14 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.53 POMC
15 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.53 GH1

Drugs & Therapeutics for Lymphocytic Hypophysitis

Drugs for Lymphocytic Hypophysitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pembrolizumab Approved Phase 1, Phase 2 1374853-91-4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 MK-3475 in Combination With MRI-guided Laser Ablation in Recurrent Malignant Gliomas Recruiting NCT02311582 Phase 1, Phase 2

Search NIH Clinical Center for Lymphocytic Hypophysitis

Genetic Tests for Lymphocytic Hypophysitis

Anatomical Context for Lymphocytic Hypophysitis

MalaCards organs/tissues related to Lymphocytic Hypophysitis:

41
Pituitary, Thyroid, Eye, Hypothalamus

Publications for Lymphocytic Hypophysitis

Articles related to Lymphocytic Hypophysitis:

(show top 50) (show all 206)
# Title Authors Year
1
Lymphocytic Hypophysitis Secondary to Ruptured Rathke Cleft Cyst: Case Report and Literature Review. ( 29572168 )
2018
2
Neuro-radiological features can predict hypopituitarism in primary autoimmune hypophysitis. ( 29752700 )
2018
3
Diagnosis and management of lymphocytic hypophysitis: A synopsis on current perspective. ( 29547162 )
2018
4
Mycophenolate mofetil treatment in a patient with recurrent lymphocytic hypophysitis. ( 29306856 )
2018
5
Diabetes insipidus is an unfavorable prognostic factor for response to glucocorticoids in patients with autoimmune hypophysitis. ( 29141992 )
2018
6
Lymphocytic hypophysitis associated with Behcet's disease: A case report and review of the literature. ( 29803206 )
2018
7
Corticosteroids in the management of lymphocytic hypophysitis: Case series. ( 29547161 )
2018
8
Primary lymphocytic hypophysitis: Clinical characteristics and treatment of 50 cases in a single centre in China over 18A years. ( 28423475 )
2017
9
Diabetes insipidus is an unfavorable prognostic factor for response to glucocorticoids in patients with autoimmune hypophysitis. ( 28626085 )
2017
10
Occurrence of primary lymphocytic hypophysitis in two horses and presence of scattered T-lymphocytes in the normal equine pituitary gland. ( 27852816 )
2017
11
Lymphocytic Hypophysitis Mimicking Pituitary Macroadenoma. ( 28527171 )
2017
12
Lymphocytic Hypophysitis Successfully Treated with Stereotactic Radiosurgery: Case Report and Review of the Literature. ( 28743133 )
2017
13
Lymphocytic hypophysitis: modern day management with limited role for surgery. ( 27778295 )
2016
14
VARIATIONS IN CLINICAL AND IMAGING FINDINGS BY TIME OF DIAGNOSIS IN FEMALES WITH HYPOPITUITARISM ATTRIBUTED TO LYMPHOCYTIC HYPOPHYSITIS. ( 26595515 )
2016
15
Clinical profile of lymphocytic hypophysitis. ( 27728211 )
2016
16
A study of primary hypophysitis, i.e., two cases of lymphocytic hypophysitis and one IgG4-related variant: The importance of measuring serum IgG4 levels to allow early diagnosis and prompt treatment for the IgG4-related variant. ( 27375049 )
2016
17
Lymphocytic hypophysitis in nonpregnant middle-aged females mimicking pituitary adenoma. ( 26732199 )
2016
18
Management of lymphocytic hypophysitis. ( 26963662 )
2016
19
A primer on pituitary injury for the obstetrician gynecologist: Simmonds disease, Sheehan's syndrome, Traumatic injury, Dahan' s syndrome, Pituitary Apoplexy and Lymphocytic Hypophysitis. ( 27405776 )
2016
20
Cerebral Vasospasm Following Transsphenoidal Hypophysectomy in the Treatment of Lymphocytic Hypophysitis. ( 27244208 )
2016
21
Lymphocytic hypophysitis: An unusual etiology of a usual presentation. ( 27728188 )
2016
22
Granulomatous and lymphocytic hypophysitis - are they immunologically distinct? ( 27704605 )
2016
23
HLA Markers DQ8 and DR53 Are Associated With Lymphocytic Hypophysitis and May Aid in Differential Diagnosis. ( 26317559 )
2015
24
Lymphocytic hypophysitis in the elderly. ( 26094558 )
2015
25
Clinical course of IgG4-related hypophysitis presenting with focal seizure and relapsing lymphocytic hypophysitis. ( 26510826 )
2015
26
LYMPHOCYTIC HYPOPHYSITIS: A RARE AUTOIMMUNE DISORDER PRESENT IN A LARGE SUPRA SELLAR MASS HAVING COMPLETE RESOLUTION WITH STEROIDS. ( 26411146 )
2015
27
Autoimmune lymphocytic hypophysitis in association with autoimmune eye disease and sequential treatment with infliximab and rituximab. ( 25224140 )
2014
28
Lymphocytic hypophysitis associated with pediatric multiple sclerosis. ( 25266625 )
2014
29
A Protracted and Aggressive Variant of Lymphocytic Hypophysitis with Mammillary Body Involvement and Cognitive Dysfunction. ( 25100390 )
2014
30
Lymphocytic hypophysitis in non-pregnant middle-aged females mimicking pituitary adenoma: A report of two cases. ( 25370565 )
2014
31
Hypopituitarism possibly due to lymphocytic hypophysitis in a patient with type 1 diabetes. ( 25175130 )
2014
32
A case of apoplectic lymphocytic hypophysitis complicated by polymyalgia rheumatica. ( 20514486 )
2013
33
Lymphocytic hypophysitis in males. ( 23485405 )
2013
34
An intrasellar germinoma with normal tumor marker concentrations mimicking primary lymphocytic hypophysitis. ( 24232824 )
2013
35
Isolated adrenocorticotropic hormone deficiency due to probable lymphocytic hypophysitis in a woman. ( 24251125 )
2013
36
Intermediate lobe immunoreactivity in a patient with suspected lymphocytic hypophysitis. ( 23329361 )
2013
37
Comment on "Lymphocytic hypophysitis with proACTH". ( 23138353 )
2012
38
Lymphocytic hypophysitis in a dog with diabetes insipidus. ( 22789859 )
2012
39
Combined granulomatous and lymphocytic hypophysitis presenting as pituitary incidentaloma in a middle-aged woman. ( 23087881 )
2012
40
Recurrent anaphylactic reactions: an uncommon debut of lymphocytic hypophysitis. ( 22573101 )
2012
41
Novel strategy to treat a case of recurrent lymphocytic hypophysitis using rituximab. ( 22443503 )
2012
42
Identification of TPIT and other novel autoantigens in lymphocytic hypophysitis: immunoscreening of a pituitary cDNA library and development of immunoprecipitation assays. ( 22193973 )
2012
43
Lymphocytic hypophysitis in a patient presenting with sequential episodes of optic neuritis. ( 20676777 )
2012
44
Reversible impairment of the processing of proopiomelanocortin into ACTH in pituitary enlargement suspected of lymphocytic hypophysitis. ( 23064477 )
2012
45
Lymphocytic hypophysitis masquerading as pituitary adenoma. ( 23565408 )
2012
46
Bilateral intracavernous carotid artery occlusion caused by invasive lymphocytic hypophysitis. ( 22749630 )
2012
47
Lymphocytic hypophysitis accompanied by aseptic meningitis mimics subacute meningoencephalitis. ( 21921390 )
2011
48
The coexistence of an intrasellar adenoma, lymphocytic hypophysitis, and primary pituitary lymphoma in a patient with acromegaly. ( 22937293 )
2011
49
Lymphocytic hypophysitis in children: a novel presentation and literature review. ( 21212455 )
2011
50
Spontaneous pregnancy in a patient with a relapse of lymphocytic hypophysitis successfully treated with azathioprine and glucocorticoids. ( 21442379 )
2011

Variations for Lymphocytic Hypophysitis

Expression for Lymphocytic Hypophysitis

Search GEO for disease gene expression data for Lymphocytic Hypophysitis.

Pathways for Lymphocytic Hypophysitis

GO Terms for Lymphocytic Hypophysitis

Cellular components related to Lymphocytic Hypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 ENO1 ENO2 ENO3 GH1 POMC
2 phosphopyruvate hydratase complex GO:0000015 8.8 ENO1 ENO2 ENO3

Biological processes related to Lymphocytic Hypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gluconeogenesis GO:0006094 9.33 ENO1 ENO2 ENO3
2 glycolytic process GO:0006096 9.13 ENO1 ENO2 ENO3
3 canonical glycolysis GO:0061621 8.8 ENO1 ENO2 ENO3

Molecular functions related to Lymphocytic Hypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 magnesium ion binding GO:0000287 9.33 ENO1 ENO2 ENO3
2 hormone activity GO:0005179 9.26 GH1 POMC
3 lyase activity GO:0016829 9.13 ENO1 ENO2 ENO3
4 phosphopyruvate hydratase activity GO:0004634 8.8 ENO1 ENO2 ENO3

Sources for Lymphocytic Hypophysitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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