MCID: LYM031
MIFTS: 61

Lymphocytic Leukemia

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Lymphocytic Leukemia

MalaCards integrated aliases for Lymphocytic Leukemia:

Name: Lymphocytic Leukemia 12 15
Lymphoblastic Leukemia 12 15
Leukaemia Lymphocytic 55
Leukemia, Lymphoid 44

Classifications:



External Ids:

Disease Ontology 12 DOID:1037
ICD10 33 C91 C91.9 C91.90
ICD9CM 35 204 204.9
MeSH 44 D007945
NCIt 50 C7539
SNOMED-CT 68 32280000 93170002
UMLS 73 C0023448

Summaries for Lymphocytic Leukemia

Disease Ontology : 12 A leukemia that has material basis in lymphoblasts (immature white blood cells).

MalaCards based summary : Lymphocytic Leukemia, also known as lymphoblastic leukemia, is related to acute lymphocytic leukemia and leukemia, chronic lymphocytic. An important gene associated with Lymphocytic Leukemia is DLEU2 (Deleted In Lymphocytic Leukemia 2), and among its related pathways/superpathways are MicroRNAs in cancer and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Arranon and Arzerra have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for Lymphocytic Leukemia

Diseases in the Lymphocytic Leukemia family:

Leukemia, Chronic Lymphocytic 2 Leukemia, Chronic Lymphocytic
Leukemia, Chronic Lymphocytic 1 Leukemia, Chronic Lymphocytic 3
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 5
Acute Lymphocytic Leukemia Adult Acute Lymphocytic Leukemia

Diseases related to Lymphocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 842)
# Related Disease Score Top Affiliating Genes
1 acute lymphocytic leukemia 34.3 TP53 TAL2 TAL1 NOTCH1 MME
2 leukemia, chronic lymphocytic 34.0 ZAP70 TRIM13 TP53 PEG10 NOTCH1 CD38
3 cll/sll 33.4 ZAP70 TP53 MME CD38 ATM
4 leukemia 32.9 TP53 TAL2 TAL1 NOTCH1 HOTAIR CLLU1
5 richter's syndrome 32.7 TP53 NOTCH1 MYC CD38 ATM
6 prolymphocytic leukemia 32.6 ZAP70 MYC CD38 ATM
7 leukemia, acute lymphoblastic 3 32.3 MME PEG10 TP53
8 leukemia, acute myeloid 32.3 CD38 HOTAIR MME MYC TP53
9 precursor t-cell acute lymphoblastic leukemia 32.2 MYC NOTCH1 TAL1
10 mantle cell lymphoma 30.9 TP53 MYC MME BTK ATM
11 lymphoma, non-hodgkin, familial 30.9 TP53 NOTCH1 MYC MME CD38 ATM
12 b-cell lymphomas 30.6 BTK HOTAIR MME MYC TP53
13 myeloma, multiple 30.6 CD38 HOTAIR MME MYC TP53
14 t-cell leukemia 30.5 ATM MYC NOTCH1 TAL1 TP53
15 diffuse large b-cell lymphoma 30.3 TP53 PEG10 MYC MME HOTAIR
16 plasmablastic lymphoma 30.3 CD38 MYC NOTCH1
17 lymphoblastic lymphoma 30.3 MME NOTCH1 TAL1
18 b cell prolymphocytic leukemia 30.0 ZAP70 TP53 MYC CD38
19 acute t cell leukemia 29.8 NOTCH1 TAL1 TAL2
20 b-cell childhood acute lymphoblastic leukemia 12.6
21 t-cell large granular lymphocyte leukemia 12.6
22 adult acute lymphocytic leukemia 12.4
23 lymphoblastic leukemia, acute, with lymphomatous features 12.4
24 large granular lymphocyte leukemia 12.4
25 acute non lymphoblastic leukemia 12.3
26 b-cell adult acute lymphocytic leukemia 12.2
27 leukemia, chronic lymphocytic 2 12.2
28 t-cell adult acute lymphocytic leukemia 12.2
29 postgerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma 12.2
30 pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma 12.2
31 acute lymphoblastic leukemia congenital sporadic aniridia 12.1
32 t-cell childhood acute lymphocytic leukemia 12.1
33 t-cell prolymphocytic leukemia 12.1
34 leukemia, acute lymphoblastic 12.0
35 leukemia, b-cell, chronic 11.9
36 acute lymphoblastic leukemia, childhood 11.8
37 precursor lymphoblastic lymphoma/leukemia 11.8
38 null-cell leukemia 11.6
39 natural killer cell leukemia 11.6
40 hairy cell leukemia 11.6
41 precursor b lymphoblastic lymphoma/leukemia 11.5
42 medulloblastoma 11.5
43 myeloid leukemia 11.5
44 ataxia-telangiectasia 11.4
45 acute leukemia 11.4
46 childhood leukemia 11.4
47 lymphoid leukemia 11.4
48 immunotactoid glomerulopathy 11.4
49 precursor t-lymphoblastic lymphoma/leukemia 11.2
50 childhood precursor t-lymphoblastic lymphoma/leukemia 11.2

Graphical network of the top 20 diseases related to Lymphocytic Leukemia:



Diseases related to Lymphocytic Leukemia

Symptoms & Phenotypes for Lymphocytic Leukemia

MGI Mouse Phenotypes related to Lymphocytic Leukemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.85 ATM BTK CD38 MYC NOTCH1 SETDB2
2 immune system MP:0005387 9.65 ATM BTK CD38 MME MYC NOTCH1
3 integument MP:0010771 9.23 ATM BTK MME MYC NOTCH1 TAL1

Drugs & Therapeutics for Lymphocytic Leukemia

FDA approved drugs:

(show all 15)
# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Arranon 18 49 NELARABINE GlaxoSmithKline October 2005
2
Arzerra 18 49 OFATUMUMAB GlaxoSmithKline October 2009
3
Blincyto 18 49 BLINATUMOMAB Amgen December 2014
4
Campath 18 49 ALEMTUZUMAB Berlex Laboratories May 2001
5
Clolar 18 49 CLOFARABINE Genzyme December, 2004
6
Elliotts B Solution 18 CALCIUM CHLORIDE; DEXTROSE; MAGNESIUM SULFATE; POTASSIUM CHLORIDE; SODIUM BICARBONATE; SODIUM CHLORIDE; SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE Orphan Medical October 1996
7
Erwinaze 18 49 asparaginase Erwinia chrysanthemi Eusa Pharma November of 2011
8
Gazyva 18 49 OBINUTUZUMAB Genentech October of 2013
9
Iclusig 18 49 PONATINIB HYDROCHLORIDE Ariad Pharmaceuticals December 2012
10
Imbruvica 18 49 IBRUTINIB Pharmacyclics November of 2013/February 2014
11
Marqibo 18 49 VINCRISTINE SULFATE Talon Therapeutics August 2012
12
Revlimid 18 49 LENALIDOMIDE Celgene June 2013
13
Sprycel 18 49 DASATINIB Bristol-Myers Squibb June 2006
14
Treanda 18 49 BENDAMUSTINE HYDROCHLORIDE Cephalon October 2008
15
Zydelig 18 49 IDELALISIB Gilead July 2014

Drugs for Lymphocytic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 700)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 58-61-7 60961
2
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 6055-19-2, 50-18-0 2907
3
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 174722-31-7 10201696
4
Pentostatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53910-25-1 439693 40926
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
6
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58957-92-9 42890
7
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 6006 143
8
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1177-87-3
9
Cytarabine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 147-94-4 6253
10
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
11
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 135968-09-1
12
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
13
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-05-2, 1959-05-2 126941
14
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
15
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
16
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 57-22-7, 2068-78-2 5978
17
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
18
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 302962-49-8 3062316
19
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 20830-81-3 30323
20
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 65271-80-9 4212
21
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-23-7 5754
22
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-03-3
23
Teniposide Approved Phase 4,Phase 3,Phase 2,Not Applicable 29767-20-2 34698
24
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 130167-69-0
25
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 23214-92-8 31703
26
Cladribine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 4291-63-8 20279
27
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 33419-42-0 36462
28
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 154-42-7 2723601
29
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 75607-67-9, 21679-14-1 30751
30
Vindesine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 59917-39-4, 53643-48-4 40839
31
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 3778-73-2 3690
32
Chlorambucil Approved Phase 4,Phase 3,Phase 2,Phase 1 305-03-3 2708
33
Vidarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 24356-66-9 32326 21704
34
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
35
Ofatumumab Approved Phase 4,Phase 3,Phase 2,Phase 1 679818-59-8 6918251
36
Thiotepa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52-24-4 5453
37
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 55-98-1 2478
38
Epirubicin Approved Phase 4,Phase 3,Phase 2 56420-45-2 41867
39
Valganciclovir Approved, Investigational Phase 4,Phase 2,Not Applicable 175865-60-8 64147
40
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 3081921 477468
41
Posaconazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 171228-49-2 147912
42
Methylphenidate Approved, Investigational Phase 4,Not Applicable 113-45-1 4158
43
Dopamine Approved Phase 4,Not Applicable 51-61-6, 62-31-7 681
44
Oprelvekin Approved, Investigational Phase 4 145941-26-0
45
Morphine Approved, Investigational Phase 4,Phase 3,Not Applicable 57-27-2 5288826
46
Decitabine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 2353-33-5 451668
47
Azacitidine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 320-67-2 9444
48
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 5280965 14956
49
Nicotine Approved Phase 4 54-11-5 942 89594
50
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-30-3 6037

Interventional clinical trials:

(show top 50) (show all 2862)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Nipent, Cytoxan and Rituxan in the Treatment of Chronic Lymphocytic Leukemia. Unknown status NCT00131313 Phase 4 Nipent, Cytoxan, Rituxan
2 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
3 Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients Unknown status NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
4 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
5 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Unknown status NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
6 Treatment of High Risk Adult Acute Lymphoblastic Leukemia Unknown status NCT00853008 Phase 4 Vincristine;Daunorubicin;Prednisone;Mitoxantrone;Cytosine Arabinoside;Dexamethasone;Methotrexate (MTX);Cytarabine;ASP;Mercaptopurine;Teniposide;Hydrocortisone
7 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
8 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
9 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Unknown status NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
10 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
11 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
12 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
13 Low Grade Lymphoma Unknown status NCT01698866 Phase 4
14 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
15 A Study of MabThera Added to Bendamustine or Chlorambucil in Patients With Chronic Lymphocytic Leukemia (MaBLe) Completed NCT01056510 Phase 4 bendamustine;chlorambucil;rituximab [MabThera/Rituxan]
16 Antiviral Treatment of Chronic Lymphocytic Leukemia Completed NCT01255644 Phase 4 Valganciclovir
17 A Study to Compare Mabthera (Rituximab), Fludarabine and Cyclophosphamide to Mabthera and Chlorambucil in Patients With Chronic Lymphocytic Leukemia and Unfavourable Somatic Status Completed NCT01283386 Phase 4 chlorambucil;cyclophosphamide;fludarabine;rituximab [MabThera]
18 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
19 Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
20 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
21 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
22 LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4 Prednisolone;Daunorubicin;Vincristine;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside
23 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin;Mercaptopurine;Prednisone;Vincristine;Methotrexate
24 LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive Completed NCT00526305 Phase 4 Vincristine;Daunorubicin;Prednisone;L-Asparaginase;Mitoxantrone;Cytosine Arabinoside;Hydrocortisone;Mercaptopurine;Cyclophosphamide;Dexamethasone
25 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
26 Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Completed NCT01200355 Phase 4 micafungin;posaconazole
27 Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
28 A Study to Confirm the Efficacy and Safety of Fludarabine Phosphate Administered in Untreated Chronic Lymphocytic Leukemia Patients With Anemia and/or Thrombocytopenia Completed NCT00220311 Phase 4 Fludarabine Phosphate (Fludara)
29 ALL-REZ BFM 2002: Multi-Center Study for Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
30 Efficacy and Safety of Ofatumumab Retreatment and Maintenance Treatment in Patients With B-cell Chronic Lymphocytic Leukemia (CLL) Completed NCT00802737 Phase 4 Ofatumumab
31 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4 Methylphenidate
32 The Duration of Humoral Immunity and the Memory Cell Function After Vaccination With 7-valent Pneumococcal Conjugate Vaccine in CLL Completed NCT00919321 Phase 4
33 Effect of Epoetin Alfa on Hemoglobin, Symptom Distress, and Quality of Life in Patients Receiving Chemotherapy Completed NCT00524407 Phase 4 Epoetin alfa
34 LAL-BR/2001: Study Treatment to Low Risk ALL Completed NCT00526175 Phase 4 Prednisone;Vincristine;Daunorubicin;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside;Mercaptopurine;VP-16
35 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4 rhIL-11
36 The Study on the Pharmacokinetics of PEG-rhG-CSF in Children and Adolescents Completed NCT02953730 Phase 4 PEG-rhG-CSF
37 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
38 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4 Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
39 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
40 Nilotinib in Newly Diagnosed Adult Philadelphia Chromosome & /or BCR-ABL Positive Chronic Myeloid Leukaemia in Chronic Phase Completed NCT01061177 Phase 4 Nilotinib
41 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
42 Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years) Recruiting NCT01366898 Phase 4 Dexamethasona, Idarubicine, ARA-C, Methotrexate
43 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
44 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid Recruiting NCT01906671 Phase 4 Xaluprine;Puri-Nethol
45 PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years Recruiting NCT01358201 Phase 4 vINCRISTINE;Dexamethasone;Methotrexate;Cytosine arabinoside
46 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
47 Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Recruiting NCT02036489 Phase 4 Vincristine;Daunorubicin;Prednisone;L-asparaginase;Ciclophosphamide;Metotrexate;ARA-C;Hidrocortisone;Mercaptopurine;VP-16;Dexametasone
48 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4 Anti-human Thymoglobulin;Placebo
49 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate
50 G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor Recruiting NCT02933333 Phase 4

Search NIH Clinical Center for Lymphocytic Leukemia

Cochrane evidence based reviews: leukemia, lymphoid

Genetic Tests for Lymphocytic Leukemia

Anatomical Context for Lymphocytic Leukemia

MalaCards organs/tissues related to Lymphocytic Leukemia:

41
B Cells, T Cells, Bone, Bone Marrow, Myeloid, B Lymphoblasts, Testes

Publications for Lymphocytic Leukemia

Articles related to Lymphocytic Leukemia:

(show top 50) (show all 11410)
# Title Authors Year
1
Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia. ( 30216644 )
2019
2
Paraneoplastic hypereosinophilic syndrome associated with IL3-IgH positive acute lymphoblastic leukemia. ( 30207070 )
2019
3
DNA methylation and obesity in survivors of pediatric acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study. ( 30382603 )
2019
4
Considerations for monitoring minimal residual disease using immunoglobulin clonality in patients with precursor B-cell lymphoblastic leukemia. ( 30389459 )
2019
5
Bilateral trifocal IOL implantation in a pediatric case of cataract following steroid-therapy for acute lymphoblastic leukemia. ( 30555958 )
2019
6
Impairment of Vα24-Jα18+Vβ11+ natural killer T cells in adult acute lymphoblastic leukemia patients. ( 30439366 )
2019
7
T-Cell Receptor Rearrangements Determined Using Fragment Analysis in Patients With T-Acute Lymphoblastic Leukemia. ( 30430774 )
2019
8
Efficacy and safety of bispecific T-cell engager (BiTE) antibody blinatumomab for the treatment of relapsed/refractory acute lymphoblastic leukemia and non-Hodgkin's lymphoma: a systemic review and meta-analysis. ( 30479190 )
2019
9
The rare translocation t(14;21)(q11;q22) detected in a Moroccan patient with T-cell acute lymphoblastic leukemia. ( 30533380 )
2019
10
In Vitro Cytotoxicity of Folate-Silica-Gold Nanorods on Mouse Acute Lymphoblastic Leukemia and Spermatogonial Cells. ( 30507084 )
2019
11
The depletion of PHF6 decreases the drug sensitivity of T-cell acute lymphoblastic leukemia to prednisolone. ( 30551478 )
2019
12
TCF7L2 activated HOXA-AS2 decreased the glucocorticoid sensitivity in acute lymphoblastic leukemia through regulating HOXA3/EGFR/Ras/Raf/MEK/ERK pathway. ( 30551418 )
2019
13
Ex-Vivo Signal Transduction Studies in Chronic Lymphocytic Leukemia. ( 30350193 )
2019
14
Ex Vivo Pharmacological Profiling in Chronic Lymphocytic Leukemia Cells. ( 30350194 )
2019
15
Culture and Harvest of CpG-Stimulated Peripheral Blood or Bone Marrow in Chronic Lymphocytic Leukemia. ( 30350195 )
2019
16
Analysis of Common Abnormalities Seen in Chronic Lymphocytic Leukemia Using Fluorescence In Situ Hybridization. ( 30350196 )
2019
17
Immunoglobulin Gene Analysis in Chronic Lymphocytic Leukemia. ( 30350197 )
2019
18
Methods for Investigating VLA-4 (CD49d/CD29) Expression and Activation in Chronic Lymphocytic Leukemia and Its Clinical Applications. ( 30350200 )
2019
19
Extracellular Flux Assays to Determine Oxidative Phosphorylation and Glycolysis in Chronic Lymphocytic Leukemia Cells. ( 30350202 )
2019
20
Measurement of Leukemic B-Cell Growth Kinetics in Patients with Chronic Lymphocytic Leukemia. ( 30350203 )
2019
21
Minimal Residual Disease Quantification in Chronic Lymphocytic Leukemia: Clinical Significance and Flow Cytometric Methods. ( 30350209 )
2019
22
Measurement of miRNAs in Chronic Lymphocytic Leukemia Patient Samples by Quantitative Reverse Transcription PCR. ( 30350212 )
2019
23
Genome Sequencing and Analysis Methods in Chronic Lymphocytic Leukemia. ( 30350214 )
2019
24
High-Throughput Sequencing of the T-Cell Receptor Beta Chain Gene Repertoire in Chronic Lymphocytic Leukemia. ( 30350216 )
2019
25
Asparaginase products in upfront acute lymphoblastic leukemia therapy: Value, location, and style. ( 30318846 )
2019
26
Clinical and biological relevance of genetic alterations in pediatric T-cell acute lymphoblastic leukemia in Taiwan. ( 30280491 )
2019
27
A cost-effectiveness analysis of Erwinia asparaginase therapy in children with acute lymphoblastic leukemia. ( 30246496 )
2019
28
Significance of CNS 2 cerebrospinal fluid status post-induction in pediatric and adolescent patients with acute lymphoblastic leukemia. ( 30207055 )
2019
29
Cross-sectional physician survey on the use of minimal residual disease testing in the management of pediatric and adult patients with acute lymphoblastic leukemia. ( 30129384 )
2019
30
Osteonecrosis in children with acute lymphoblastic leukemia: A report from Children's Cancer Hospital Egypt (CCHE). ( 30183135 )
2019
31
An Evidence-based Review of Anti-CD20 Antibody-containing Regimens for the Treatment of Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Diffuse Large B-cell Lymphoma, or Follicular Lymphoma. ( 29934061 )
2018
32
Highly similar genomic landscapes in monoclonal B-cell lymphocytosis and ultra-stable chronic lymphocytic leukemia with low frequency of driver mutations. ( 29449433 )
2018
33
Immunosuppressive monocytes (CD14<sup>+</sup>/HLA-DR<sup>low/-</sup>) increase in childhood precursor B-cell acute lymphoblastic leukemia after induction chemotherapy. ( 29429058 )
2018
34
A Chronic Lymphocytic Leukemia Patient with Progressive Multifocal Leukoencephalopathy Caused by John Cunningham Virus. ( 29950535 )
2018
35
Genetic predisposition to B-cell acute lymphoblastic leukemia at 14q11.2 is mediated by a CEBPE promoter polymorphism. ( 29977016 )
2018
36
Simultaneous finding of chronic lymphocytic leukemia and residual hairy cell leukemia using a lymphocyte-binding anti-CD antibody microarray. ( 29636954 )
2018
37
The histone demethylase PHF8 promotes adult acute lymphoblastic leukemia through interaction with the MEK/ERK signaling pathway. ( 29330049 )
2018
38
Anti-E Detected in a 7-Month-Old Infant with Acute Lymphoblastic Leukemia after Transfusion. ( 29945333 )
2018
39
Trisomy 12 chronic lymphocytic leukemia expresses a unique set of activated and targetable pathways. ( 29976738 )
2018
40
Acute Lymphoblastic Leukemia Presenting as Fanconi Syndrome. ( 29515412 )
2018
41
Low Incidence of Osteonecrosis in Childhood Acute Lymphoblastic Leukemia Treated With ALL-97 and ALL-02 Study of Japan Association of Childhood Leukemia Study Group. ( 29360413 )
2018
42
Mutational status of NRAS, KRAS, and PTPN11 genes is associated with genetic/cytogenetic features in children with B-precursor acute lymphoblastic leukemia. ( 28853218 )
2018
43
Long non-coding RNA PAX8-AS1 polymorphisms increase the risk of childhood acute lymphoblastic leukemia. ( 29435279 )
2018
44
Cutaneous Mucormycosis Following a Bullous Pemphigoid Flare in a Chronic Lymphocytic Leukemia Patient on Ibrutinib. ( 29760835 )
2018
45
Pure red cell aplasia with t-cell large granular lymphocytic leukemia. ( 29921385 )
2018
46
Cerebral aspergillosis: An emerging opportunistic infection in patients receiving ibrutinib for chronic lymphocytic leukemia? ( 29402474 )
2018
47
Study of NOTCH1 and FBXW7 Mutations and Its Prognostic Significance in South Indian T-Cell Acute Lymphoblastic Leukemia. ( 29200162 )
2018
48
Composite Lymphoma as Co-occurrence of Advanced Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Carrying Trisomy 12 and t(14;18) and Peripheral T-cell Lymphoma. ( 29415977 )
2018
49
Distribution of Curcumin and THC in Peripheral Blood Mononuclear Cells Isolated from Healthy Individuals and Patients with Chronic Lymphocytic Leukemia. ( 29277764 )
2018
50
Effect of allogeneic blood transfusion on levels of IL-6 and sIL-R2 in peripheral blood of children with acute lymphocytic leukemia. ( 29963154 )
2018

Variations for Lymphocytic Leukemia

Copy number variations for Lymphocytic Leukemia from CNVD:

7 (show top 50) (show all 117)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 15722 1 118792737 119283944 Deletion lymphocytic leukemia
2 174990 3 36967519 37301610 Deletion lymphocytic leukemia
3 174335 3 23938864 24184494 Deletion lymphocytic leukemia
4 171887 3 173687986 180776184 Deletion lymphocytic leukemia
5 171361 3 166401814 166712788 Deletion lymphocytic leukemia
6 169047 3 136891829 139071546 Duplication lymphocytic leukemia
7 168798 3 133426459 133822407 Deletion lymphocytic leukemia
8 168129 3 127341829 129920493 Duplication lymphocytic leukemia
9 168128 3 127341829 129920493 Copy number lymphocytic leukemia
10 167247 3 115404001 124892494 Deletion lymphocytic leukemia
11 162192 22 21330008 21570697 Deletion lymphocytic leukemia
12 162023 22 21044595 21570697 Deletion lymphocytic leukemia
13 159323 21 41514980 46912065 Deletion lymphocytic leukemia
14 157290 21 14429720 46912065 Duplication lymphocytic leukemia
15 156983 20 9944 7553629 Deletion lymphocytic leukemia
16 155940 20 59074507 62317284 Duplication lymphocytic leukemia
17 150992 20 16086026 19632379 Duplication lymphocytic leukemia
18 149838 2 95110968 151785533 Deletion lymphocytic leukemia
19 147121 2 60466431 61759445 Duplication lymphocytic leukemia
20 145974 2 44073 64590503 Duplication lymphocytic leukemia
21 145973 2 44073 60812692 Duplication lymphocytic leukemia
22 142037 2 219234883 220344370 Deletion lymphocytic leukemia
23 87239 14 72506787 72834048 Deletion lymphocytic leukemia
24 42565 10 3607230 9585338 Duplication lymphocytic leukemia
25 37922 1 96795246 110397675 Deletion lymphocytic leukemia
26 37449 1 912529 45151506 Deletion lymphocytic leukemia
27 37448 1 912529 3548139 Duplication lymphocytic leukemia
28 37447 1 912529 3454889 Duplication lymphocytic leukemia
29 37391 1 902529 3454889 Duplication lymphocytic leukemia
30 35452 1 63608956 78245151 Deletion lymphocytic leukemia
31 29239 1 229351994 229691388 Deletion lymphocytic leukemia
32 28304 1 221094574 222727272 Deletion lymphocytic leukemia
33 252990 9 38261089 119714054 Deletion lymphocytic leukemia
34 250850 9 22407649 22847775 Deletion lymphocytic leukemia
35 249815 9 188707 27863525 Deletion lymphocytic leukemia
36 249450 9 14515097 22847775 Deletion lymphocytic leukemia
37 243585 8 86064184 146236298 Duplication lymphocytic leukemia
38 243036 8 77643686 79802767 Deletion lymphocytic leukemia
39 239563 8 39514037 39797061 Deletion lymphocytic leukemia
40 238909 8 345060 111175147 Deletion lymphocytic leukemia
41 237712 8 2530350 5909600 Deletion lymphocytic leukemia
42 234846 8 13967960 17118468 Deletion lymphocytic leukemia
43 233367 8 124436106 146015567 Duplication lymphocytic leukemia
44 232516 8 117699992 120401821 Duplication lymphocytic leukemia
45 232342 8 115351618 116782788 Deletion lymphocytic leukemia
46 232341 8 115351618 115731259 Deletion lymphocytic leukemia
47 228763 7 81021736 96580930 Deletion lymphocytic leukemia
48 223617 7 2327342 54294538 Deletion lymphocytic leukemia
49 217732 7 102955780 158788150 Deletion lymphocytic leukemia
50 216861 6 98941606 99824130 Copy number lymphocytic leukemia

Expression for Lymphocytic Leukemia

Search GEO for disease gene expression data for Lymphocytic Leukemia.

Pathways for Lymphocytic Leukemia