MCID: LYM045
MIFTS: 36

Lymphocytic Vasculitis

Categories: Rare diseases, Immune diseases, Cardiovascular diseases

Aliases & Classifications for Lymphocytic Vasculitis

MalaCards integrated aliases for Lymphocytic Vasculitis:

Name: Lymphocytic Vasculitis 53
Vasculitis Lymphocytic, Nodular 53

Classifications:



Summaries for Lymphocytic Vasculitis

NIH Rare Diseases : 53 Lymphocytic vasculitis is one of several skin conditions which are collectively referred to as cutaneous vasculitis. In lymphocytic vasculitis, white blood cells (lymphocytes) cause damage to blood vessels in the skin. This condition is thought to be caused by a number of factors, but the exact cause of most cases is not known. This disease can present with a variety of symptoms, depending on the size, location, and severity of the affected area. In a minority of patients, cutaneous vasculitis can be part of a more severe vasculitis affecting other organs in the body - this is known as systemic vasculitis.

MalaCards based summary : Lymphocytic Vasculitis, also known as vasculitis lymphocytic, nodular, is related to vasculitis and dengue disease. An important gene associated with Lymphocytic Vasculitis is SH2D1A (SH2 Domain Containing 1A), and among its related pathways/superpathways are Integrin Pathway and Degradation of the extracellular matrix. The drugs Chromium and Cobalt have been mentioned in the context of this disorder. Affiliated tissues include skin, myeloid and t cells, and related phenotypes are hematopoietic system and immune system

Related Diseases for Lymphocytic Vasculitis

Diseases related to Lymphocytic Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 vasculitis 30.3 ICAM1 SELE VCAM1
2 dengue disease 29.6 ICAM1 VCAM1
3 systemic lupus erythematosus 28.3 ICAM1 ITGAM SELE VCAM1
4 vasculitis, lymphocytic, nodular 12.2
5 heterophyiasis 10.4 ICAM1 SELE
6 plummer's disease 10.4 ICAM1 SELE
7 hymenolepiasis 10.4 ICAM1 SELE
8 leukocyte adhesion deficiency, type i 10.4 ITGAM SELE
9 endophthalmitis 10.4 ICAM1 SELE
10 hypersensitivity reaction type iii disease 10.4 ICAM1 SELE
11 penicilliosis 10.4 ITGAL ITGAM
12 cortical thymoma 10.3 ICAM1 VCAM1
13 autoimmune enteropathy 10.3 ICAM1 ITGAL
14 plasmodium vivax malaria 10.3 ICAM1 SELE
15 immune-complex glomerulonephritis 10.3 ICAM1 VCAM1
16 neutrophil migration 10.3 ICAM1 ITGAM
17 limbal stem cell deficiency 10.3 ICAM1 VCAM1
18 henoch-schoenlein purpura 10.3 ICAM1 VCAM1
19 chronic monocytic leukemia 10.3 ITGAM ITGAX
20 cutaneous lupus erythematosus 10.3 ICAM1 SELE
21 arteriosclerosis obliterans 10.2 ICAM1 VCAM1
22 venous insufficiency 10.2 ICAM1 VCAM1
23 crescentic glomerulonephritis 10.2 ICAM1 VCAM1
24 pustulosis palmaris et plantaris 10.2 ITGAL SELE
25 allergic contact dermatitis 10.2 ICAM1 SELE
26 oral lichen planus 10.2 ICAM1 VCAM1
27 primary progressive multiple sclerosis 10.2 ICAM1 VCAM1
28 benign cephalic histiocytosis 10.1 ITGAL ITGAX
29 contact dermatitis 10.1 ICAM1 SELE
30 microvascular complications of diabetes 1 10.1 ICAM1 VCAM1
31 peritonitis 10.1 ICAM1 ITGAM
32 diffuse infiltrative lymphocytosis syndrome 10.0 ITGAL ITGAX
33 chronic venous insufficiency 9.9 ICAM1 ITGAM VCAM1
34 takayasu arteritis 9.9 SELE VCAM1
35 mooren's ulcer 9.9 ICAM1 SELE VCAM1
36 subendocardial myocardial infarction 9.8 ICAM1 SELE VCAM1
37 rheumatoid vasculitis 9.8 ICAM1 SELE VCAM1
38 leukemia 9.8
39 leukostasis 9.8 ICAM1 SELE VCAM1
40 cytomegalovirus infection 9.8 ICAM1 SELE VCAM1
41 microvascular complications of diabetes 5 9.8 ICAM1 VCAM1
42 autoinflammation, lipodystrophy, and dermatosis syndrome 9.8 ICAM1 SELE VCAM1
43 synovitis 9.8 ICAM1 SELE VCAM1
44 arteries, anomalies of 9.8 ICAM1 SELE VCAM1
45 atherosclerosis susceptibility 9.8 ICAM1 SELE VCAM1
46 arteriosclerosis 9.8 ICAM1 SELE VCAM1
47 cerebrovascular disease 9.8 ICAM1 SELE VCAM1
48 plasmodium falciparum malaria 9.8 ICAM1 SELE
49 leukemia, b-cell, chronic 9.7
50 leukemia, chronic lymphocytic 2 9.7

Graphical network of the top 20 diseases related to Lymphocytic Vasculitis:



Diseases related to Lymphocytic Vasculitis

Symptoms & Phenotypes for Lymphocytic Vasculitis

MGI Mouse Phenotypes related to Lymphocytic Vasculitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 ICAM1 ITGAL ITGAM ITGAX SELE SH2D1A
2 immune system MP:0005387 9.17 ICAM1 ITGAL ITGAM ITGAX SELE SH2D1A

Drugs & Therapeutics for Lymphocytic Vasculitis

Drugs for Lymphocytic Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chromium Approved 7440-47-3 27668
2
Cobalt 7440-48-4 104729

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Magnetic Resonance Imaging as a Biomarker For Adverse Local Tissue Reaction In Individuals With Hip Arthroplasty Recruiting NCT02255331

Search NIH Clinical Center for Lymphocytic Vasculitis

Genetic Tests for Lymphocytic Vasculitis

Anatomical Context for Lymphocytic Vasculitis

MalaCards organs/tissues related to Lymphocytic Vasculitis:

41
Skin, Myeloid, T Cells, B Cells, Neutrophil, Prostate, Skeletal Muscle

Publications for Lymphocytic Vasculitis

Articles related to Lymphocytic Vasculitis:

(show all 41)
# Title Authors Year
1
Histopathologic Finding of Perieschar Lesions in Tsutsugamushi Disease Shows Lymphocytic Vasculitis Mimicking Angiocentric Lymphoma. ( 29386829 )
2018
2
Benign Atrophic Papulosis (Degos Disease) With Lymphocytic Vasculitis and Lichen Sclerosus-Like Features. ( 28244939 )
2017
3
Rituximab as a Second-Line Treatment for Lymphocytic Vasculitis of the Central Nervous System. ( 28471627 )
2016
4
Testicular lymphocytic vasculitis treated with prednisolone and azathioprine. ( 25736359 )
2015
5
Lymphocytic vasculitis of the uterus in a patient with melanoma receiving ipilimumab. ( 23733772 )
2013
6
Incidence of pseudotumor and acute lymphocytic vasculitis associated lesion (ALVAL) reactions in metal-on-metal hip articulations: a meta-analysis. ( 23660012 )
2013
7
Macular Lymphocytic Arteritis: Three Cases Questioning Its Classification as Primary Lymphocytic Vasculitis. ( 24334907 )
2013
8
Perfusion and spectroscopy magnetic resonance imaging in a case of lymphocytic vasculitis mimicking brain tumor. ( 24115963 )
2013
9
Acute myeloid leukemia presenting with cutaneous infiltrates in a patient receiving etanercept for chronic lymphocytic vasculitis. ( 23158628 )
2012
10
Lymphocytic vasculitis of the prostate transition zone. ( 22462607 )
2012
11
MRI of aseptic lymphocytic vasculitis-associated lesions in metal-on-metal hip replacements. ( 22623554 )
2012
12
Parallel correlation of immunofluorescence studies with clinical course in a patient with influenza vaccine-induced lymphocytic vasculitis. ( 18631204 )
2009
13
Lymphocytic vasculitis involving the central nervous system occurs in patients with X-linked lymphoproliferative disease in the absence of Epstein-Barr virus infection. ( 19621458 )
2009
14
Necrotizing lymphocytic vasculitis limited to the peripheral nerves: report of six cases and review. ( 20204175 )
2009
15
The enigma of lymphocytic vasculitis. ( 18794469 )
2008
16
Cutaneous vasculitis update: neutrophilic muscular vessel and eosinophilic, granulomatous, and lymphocytic vasculitis syndromes. ( 17284960 )
2007
17
Lymphocytic vasculitis associated with icodextrin. ( 17984440 )
2007
18
Cutaneous lymphocytic vasculitis during TNFalpha antagonist therapy for polyarthritis. ( 16213773 )
2006
19
Atypical lymphocytic reaction with epidermotropism and lymphocytic vasculopathic reaction (lymphocytic vasculitis) after treatment with imiquimod. ( 17052533 )
2006
20
X-linked lymphoproliferative syndrome presenting with systemic lymphocytic vasculitis. ( 15682426 )
2005
21
Dominantly inherited cutaneous small-vessel lymphocytic vasculitis maps to chromosome 6q26-q27. ( 16133183 )
2005
22
Lymphocytic vasculitis mimicking aggressive multifocal cerebral neoplasm: mr imaging and MR spectroscopic appearance. ( 15760879 )
2005
23
Cyclic lymphocytic vasculitis associated with chronic lymphocytic leukemia. ( 15160961 )
2004
24
Lymphocytic vasculitis associated with the anthrax vaccine: case report and review of anthrax vaccination. ( 14585454 )
2003
25
A case suggesting lymphocytic vasculitis as a presenting sign of early undifferentiated connective tissue disease. ( 14501291 )
2003
26
Cutaneous lymphocytic vasculitis as the presenting feature of acute lymphoblastic leukemia. ( 12368694 )
2002
27
Lymphocytic vasculitis in X-linked lymphoproliferative disease. ( 11133747 )
2001
28
Defining lymphocytic vasculitis. ( 10954985 )
2000
29
Renal failure due to T-cell mediated lymphocytic vasculitis: an unusual complication of B-cell chronic lymphocytic leukemia. ( 10977810 )
2000
30
A Japanese case of dengue fever with lymphocytic vasculitis: diagnosis by polymerase chain reaction. ( 10063209 )
1999
31
A case of lymphocytic vasculitis with infiltration of dermal nerves resembling indeterminate leprosy. ( 9614840 )
1998
32
Lymphocytic vasculitis presenting as diffuse subcutaneous edema after hepatitis B virus vaccine. ( 19078176 )
1997
33
Cutaneous lymphocytic vasculitis in acute myeloid leukaemia. ( 8949448 )
1996
34
Cutaneous lymphocytic vasculitis: a definition, a review, and a proposed classification. ( 8834516 )
1996
35
Cutaneous lymphocytic vasculopathy in lymphoproliferative disorders--a paraneoplastic lymphocytic vasculitis of the skin. ( 7787755 )
1995
36
Skeletal muscle lymphocytic vasculitis in systemic lupus erythematosus: relation to disease activity. ( 7795620 )
1995
37
Urticarial skin lesions and polymyositis due to lymphocytic vasculitis. ( 7725694 )
1995
38
Comparison of cell adhesion molecule expression in cutaneous leucocytoclastic and lymphocytic vasculitis. ( 7525658 )
1994
39
Glomerulonephritis and lymphocytic vasculitis associated with rifampin therapy. ( 1493242 )
1992
40
Lichenoid lymphocytic vasculitis with a high component of histiocytes. Histogenetic implications in a specified clinical setting. ( 2729528 )
1989
41
Lymphocytic vasculitis: is it a specific clinicopathologic entity? ( 6736395 )
1984

Variations for Lymphocytic Vasculitis

Expression for Lymphocytic Vasculitis

Search GEO for disease gene expression data for Lymphocytic Vasculitis.

Pathways for Lymphocytic Vasculitis

Pathways related to Lymphocytic Vasculitis according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.15 ICAM1 ITGAL ITGAM ITGAX VCAM1
2
Show member pathways
12.46 ICAM1 ITGAL ITGAM ITGAX VCAM1
3
Show member pathways
12.44 ICAM1 ITGAL ITGAM VCAM1
4 12.38 ITGAL ITGAM ITGAX
5
Show member pathways
12.29 ICAM1 ITGAL SH2D1A
6 12.22 ICAM1 ITGAL VCAM1
7
Show member pathways
12.21 ITGAL ITGAM ITGAX
8
Show member pathways
12.19 ICAM1 SELE VCAM1
9
Show member pathways
12.01 ITGAL ITGAM ITGAX SELE
10 11.95 ITGAL ITGAM ITGAX
11 11.9 ICAM1 SELE VCAM1
12 11.82 ITGAL ITGAM ITGAX
13 11.8 ICAM1 ITGAL SH2D1A VCAM1
14 11.78 ICAM1 SELE VCAM1
15 11.72 ICAM1 SELE VCAM1
16 11.68 ICAM1 ITGAM ITGAX VCAM1
17 11.64 ITGAL ITGAM ITGAX
18
Show member pathways
11.53 ICAM1 ITGAL ITGAM ITGAX VCAM1
19
Show member pathways
11.5 ICAM1 SELE VCAM1
20 11.46 ITGAL ITGAM ITGAX
21 11.43 ITGAL ITGAM ITGAX
22 11.42 ICAM1 ITGAL ITGAM
23 11.33 ICAM1 ITGAM
24 11.33 ITGAL ITGAM ITGAX
25 11.31 ICAM1 SELE VCAM1
26
Show member pathways
11.28 ITGAL VCAM1
27 11.25 ICAM1 ITGAL SELE VCAM1
28 11.18 ICAM1 ITGAL ITGAM SELE VCAM1
29 11.15 ICAM1 SELE VCAM1
30 11.1 ICAM1 ITGAL ITGAM VCAM1
31 10.8 ICAM1 VCAM1

GO Terms for Lymphocytic Vasculitis

Cellular components related to Lymphocytic Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.46 ICAM1 ITGAM ITGAX VCAM1
2 membrane raft GO:0045121 9.43 ICAM1 ITGAM SELE
3 cell surface GO:0009986 9.35 ICAM1 ITGAL ITGAM ITGAX VCAM1
4 integrin complex GO:0008305 8.8 ITGAL ITGAM ITGAX

Biological processes related to Lymphocytic Vasculitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.8 ICAM1 ITGAL ITGAM ITGAX SELE VCAM1
2 cytokine-mediated signaling pathway GO:0019221 9.76 ICAM1 ITGAM ITGAX VCAM1
3 response to lipopolysaccharide GO:0032496 9.7 ICAM1 SELE VCAM1
4 cell-cell adhesion GO:0098609 9.67 ICAM1 ITGAL VCAM1
5 regulation of immune response GO:0050776 9.67 ICAM1 ITGAL SH2D1A VCAM1
6 integrin-mediated signaling pathway GO:0007229 9.65 ITGAL ITGAM ITGAX
7 leukocyte migration GO:0050900 9.65 ICAM1 ITGAL ITGAM ITGAX SELE
8 interferon-gamma-mediated signaling pathway GO:0060333 9.55 ICAM1 VCAM1
9 extracellular matrix organization GO:0030198 9.55 ICAM1 ITGAL ITGAM ITGAX VCAM1
10 response to ionizing radiation GO:0010212 9.54 ICAM1 VCAM1
11 leukocyte tethering or rolling GO:0050901 9.51 SELE VCAM1
12 membrane to membrane docking GO:0022614 9.43 ICAM1 VCAM1
13 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002291 9.4 ICAM1 ITGAL
14 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.26 ICAM1 ITGAL SELE VCAM1
15 leukocyte cell-cell adhesion GO:0007159 8.92 ICAM1 ITGAL SELE VCAM1

Molecular functions related to Lymphocytic Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion molecule binding GO:0050839 8.62 ITGAL VCAM1

Sources for Lymphocytic Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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