MCID: LYM045
MIFTS: 34

Lymphocytic Vasculitis

Categories: Cardiovascular diseases, Immune diseases, Rare diseases

Aliases & Classifications for Lymphocytic Vasculitis

MalaCards integrated aliases for Lymphocytic Vasculitis:

Name: Lymphocytic Vasculitis 53
Vasculitis Lymphocytic, Nodular 53

Classifications:



Summaries for Lymphocytic Vasculitis

NIH Rare Diseases : 53 Lymphocytic vasculitis is one of several skin conditions which are collectively referred to as cutaneous vasculitis. In lymphocytic vasculitis, white blood cells (lymphocytes) cause damage to blood vessels in the skin. This condition is thought to be caused by a number of factors, but the exact cause of most cases is not known. This disease can present with a variety of symptoms, depending on the size, location, and severity of the affected area. In a minority of patients, cutaneous vasculitis can be part of a more severe vasculitis affecting other organs in the body - this is known as systemic vasculitis.

MalaCards based summary : Lymphocytic Vasculitis, also known as vasculitis lymphocytic, nodular, is related to vasculitis and dengue disease. An important gene associated with Lymphocytic Vasculitis is SH2D1A (SH2 Domain Containing 1A), and among its related pathways/superpathways are Integrin Pathway and Degradation of the extracellular matrix. The drugs Cobalt and Chromium have been mentioned in the context of this disorder. Affiliated tissues include skin, myeloid and brain, and related phenotypes are hematopoietic system and immune system

Related Diseases for Lymphocytic Vasculitis

Diseases related to Lymphocytic Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 vasculitis 30.6 ICAM1 SELE VCAM1
2 dengue disease 29.6 ICAM1 VCAM1
3 systemic lupus erythematosus 29.1 ICAM1 ITGAM SELE VCAM1
4 vasculitis, lymphocytic, nodular 12.4
5 chronic eosinophilic pneumonia 10.2 ICAM1 ITGAM
6 heterophyiasis 10.1 ICAM1 SELE
7 hymenolepiasis 10.1 ICAM1 SELE
8 plummer's disease 10.1 ICAM1 SELE
9 endophthalmitis 10.1 ICAM1 SELE
10 hydrocele 10.1 ICAM1 SELE
11 venous insufficiency 10.1 ICAM1 VCAM1
12 hypersensitivity reaction type iii disease 10.1 ICAM1 SELE
13 cortical thymoma 10.1 ICAM1 VCAM1
14 brachydactyly, type e2 10.1 ICAM1 VCAM1
15 plasmodium vivax malaria 10.1 ICAM1 SELE
16 immune-complex glomerulonephritis 10.1 ICAM1 VCAM1
17 vertebrobasilar insufficiency 10.1 ICAM1 SELE
18 limbal stem cell deficiency 10.1 ICAM1 VCAM1
19 neutrophil migration 10.1 ICAM1 ITGAM
20 cutaneous lupus erythematosus 10.1 ICAM1 SELE
21 henoch-schoenlein purpura 10.1 ICAM1 VCAM1
22 arteriosclerosis obliterans 10.1 ICAM1 VCAM1
23 penicilliosis 10.1 ITGAL ITGAM
24 autoimmune enteropathy 10.1 ICAM1 ITGAL
25 crescentic glomerulonephritis 10.1 ICAM1 VCAM1
26 grange syndrome 10.1 SELE VCAM1
27 localized scleroderma 10.1 SELE VCAM1
28 oral lichen planus 10.1 ICAM1 VCAM1
29 allergic contact dermatitis 10.1 ICAM1 SELE
30 primary progressive multiple sclerosis 10.0 ICAM1 VCAM1
31 contact dermatitis 10.0 ICAM1 SELE
32 maturity-onset diabetes of the young, type 7 10.0 SELE VCAM1
33 pustulosis palmaris et plantaris 10.0 ITGAL SELE
34 lichen planus 10.0 ICAM1 ITGAL
35 chronic monocytic leukemia 10.0 ITGAM ITGAX
36 leukocyte adhesion deficiency, type i 10.0 ICAM1 ITGAM SELE
37 shwartzman phenomenon 10.0 ICAM1 ITGAM VCAM1
38 takayasu arteritis 10.0 SELE VCAM1
39 chronic venous insufficiency 10.0 ICAM1 ITGAM VCAM1
40 plasmodium falciparum malaria 10.0 ICAM1 SELE
41 antiphospholipid syndrome 10.0 SELE VCAM1
42 peritonitis 10.0 ICAM1 ITGAM
43 vascular disease 10.0 ITGAM SELE VCAM1
44 mooren's ulcer 10.0 ICAM1 SELE VCAM1
45 subendocardial myocardial infarction 10.0 ICAM1 SELE VCAM1
46 rheumatoid vasculitis 10.0 ICAM1 SELE VCAM1
47 peripheral vascular disease 10.0 SELE VCAM1
48 leukostasis 10.0 ICAM1 SELE VCAM1
49 arteries, anomalies of 9.9 ICAM1 SELE VCAM1
50 synovitis 9.9 ICAM1 SELE VCAM1

Graphical network of the top 20 diseases related to Lymphocytic Vasculitis:



Diseases related to Lymphocytic Vasculitis

Symptoms & Phenotypes for Lymphocytic Vasculitis

MGI Mouse Phenotypes related to Lymphocytic Vasculitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 ICAM1 ITGAL ITGAM ITGAX SELE SH2D1A
2 immune system MP:0005387 9.17 ICAM1 ITGAL ITGAM ITGAX SELE SH2D1A

Drugs & Therapeutics for Lymphocytic Vasculitis

Drugs for Lymphocytic Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cobalt Approved, Experimental 7440-48-4 104729
2
Chromium Approved 7440-47-3 27668

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Using MRI To Detect Soft Tissue Reactions And Implant Integration As Related To Implant Modularity Recruiting NCT02255331

Search NIH Clinical Center for Lymphocytic Vasculitis

Genetic Tests for Lymphocytic Vasculitis

Anatomical Context for Lymphocytic Vasculitis

MalaCards organs/tissues related to Lymphocytic Vasculitis:

41
Skin, Myeloid, Brain, Neutrophil, B Cells, Skeletal Muscle, Monocytes

Publications for Lymphocytic Vasculitis

Articles related to Lymphocytic Vasculitis:

(show all 43)
# Title Authors Year
1
Histopathologic Finding of Perieschar Lesions in Tsutsugamushi Disease Shows Lymphocytic Vasculitis Mimicking Angiocentric Lymphoma. ( 29386829 )
2018
2
Fatal central nervous system lymphocytic vasculitis after treatment for Burkitt lymphoma in a patient with a SH2D1A mutation. ( 30138256 )
2018
3
Benign Atrophic Papulosis (Degos Disease) With Lymphocytic Vasculitis and Lichen Sclerosus-Like Features. ( 28244939 )
2018
4
Bilateral Vision Loss with p-ANCA Associated Lymphocytic Vasculitis. ( 30427747 )
2018
5
Rituximab as a Second-Line Treatment for Lymphocytic Vasculitis of the Central Nervous System. ( 28471627 )
2016
6
Testicular lymphocytic vasculitis treated with prednisolone and azathioprine. ( 25736359 )
2015
7
Lymphocytic vasculitis of the uterus in a patient with melanoma receiving ipilimumab. ( 23733772 )
2013
8
Incidence of pseudotumor and acute lymphocytic vasculitis associated lesion (ALVAL) reactions in metal-on-metal hip articulations: a meta-analysis. ( 23660012 )
2013
9
Macular Lymphocytic Arteritis: Three Cases Questioning Its Classification as Primary Lymphocytic Vasculitis. ( 24334907 )
2013
10
Perfusion and spectroscopy magnetic resonance imaging in a case of lymphocytic vasculitis mimicking brain tumor. ( 24115963 )
2013
11
Acute myeloid leukemia presenting with cutaneous infiltrates in a patient receiving etanercept for chronic lymphocytic vasculitis. ( 23158628 )
2012
12
Lymphocytic vasculitis of the prostate transition zone. ( 22462607 )
2012
13
MRI of aseptic lymphocytic vasculitis-associated lesions in metal-on-metal hip replacements. ( 22623554 )
2012
14
Parallel correlation of immunofluorescence studies with clinical course in a patient with influenza vaccine-induced lymphocytic vasculitis. ( 18631204 )
2009
15
Lymphocytic vasculitis involving the central nervous system occurs in patients with X-linked lymphoproliferative disease in the absence of Epstein-Barr virus infection. ( 19621458 )
2009
16
Necrotizing lymphocytic vasculitis limited to the peripheral nerves: report of six cases and review. ( 20204175 )
2009
17
"Lymphocytic vasculitis" is not urticarial vasculitis. ( 18638634 )
2008
18
The enigma of lymphocytic vasculitis. ( 18794469 )
2008
19
Cutaneous vasculitis update: neutrophilic muscular vessel and eosinophilic, granulomatous, and lymphocytic vasculitis syndromes. ( 17284960 )
2007
20
Lymphocytic vasculitis associated with icodextrin. ( 17984440 )
2007
21
Cutaneous lymphocytic vasculitis during TNFalpha antagonist therapy for polyarthritis. ( 16213773 )
2006
22
Atypical lymphocytic reaction with epidermotropism and lymphocytic vasculopathic reaction (lymphocytic vasculitis) after treatment with imiquimod. ( 17052533 )
2006
23
X-linked lymphoproliferative syndrome presenting with systemic lymphocytic vasculitis. ( 15682426 )
2005
24
Dominantly inherited cutaneous small-vessel lymphocytic vasculitis maps to chromosome 6q26-q27. ( 16133183 )
2005
25
Lymphocytic vasculitis mimicking aggressive multifocal cerebral neoplasm: mr imaging and MR spectroscopic appearance. ( 15760879 )
2005
26
Cyclic lymphocytic vasculitis associated with chronic lymphocytic leukemia. ( 15160961 )
2004
27
Lymphocytic vasculitis associated with the anthrax vaccine: case report and review of anthrax vaccination. ( 14585454 )
2003
28
A case suggesting lymphocytic vasculitis as a presenting sign of early undifferentiated connective tissue disease. ( 14501291 )
2003
29
Cutaneous lymphocytic vasculitis as the presenting feature of acute lymphoblastic leukemia. ( 12368694 )
2002
30
Lymphocytic vasculitis in X-linked lymphoproliferative disease. ( 11133747 )
2001
31
Defining lymphocytic vasculitis. ( 10954985 )
2000
32
Renal failure due to T-cell mediated lymphocytic vasculitis: an unusual complication of B-cell chronic lymphocytic leukemia. ( 10977810 )
2000
33
A Japanese case of dengue fever with lymphocytic vasculitis: diagnosis by polymerase chain reaction. ( 10063209 )
1999
34
A case of lymphocytic vasculitis with infiltration of dermal nerves resembling indeterminate leprosy. ( 9614840 )
1998
35
Lymphocytic vasculitis presenting as diffuse subcutaneous edema after hepatitis B virus vaccine. ( 19078176 )
1997
36
Cutaneous lymphocytic vasculitis in acute myeloid leukaemia. ( 8949448 )
1996
37
Cutaneous lymphocytic vasculitis: a definition, a review, and a proposed classification. ( 8834516 )
1996
38
Cutaneous lymphocytic vasculopathy in lymphoproliferative disorders--a paraneoplastic lymphocytic vasculitis of the skin. ( 7787755 )
1995
39
Skeletal muscle lymphocytic vasculitis in systemic lupus erythematosus: relation to disease activity. ( 7795620 )
1995
40
Urticarial skin lesions and polymyositis due to lymphocytic vasculitis. ( 7725694 )
1995
41
Glomerulonephritis and lymphocytic vasculitis associated with rifampin therapy. ( 1493242 )
1992
42
Lichenoid lymphocytic vasculitis with a high component of histiocytes. Histogenetic implications in a specified clinical setting. ( 2729528 )
1989
43
Lymphocytic vasculitis: is it a specific clinicopathologic entity? ( 6736395 )
1984

Variations for Lymphocytic Vasculitis

Expression for Lymphocytic Vasculitis

Search GEO for disease gene expression data for Lymphocytic Vasculitis.

Pathways for Lymphocytic Vasculitis

Pathways related to Lymphocytic Vasculitis according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.16 ICAM1 ITGAL ITGAM ITGAX VCAM1
2
Show member pathways
12.46 ICAM1 ITGAL ITGAM ITGAX VCAM1
3
Show member pathways
12.45 ICAM1 ITGAL ITGAM VCAM1
4 12.41 ITGAL ITGAM ITGAX
5
Show member pathways
12.31 ICAM1 ITGAL SH2D1A
6 12.22 ICAM1 ITGAL VCAM1
7
Show member pathways
12.22 ITGAL ITGAM ITGAX
8
Show member pathways
12.2 ICAM1 SELE VCAM1
9
Show member pathways
12.01 ITGAL ITGAM ITGAX
10
Show member pathways
12.01 ITGAL ITGAM ITGAX SELE
11
Show member pathways
11.98 ICAM1 ITGAL ITGAM ITGAX VCAM1
12 11.95 ITGAL ITGAM ITGAX
13 11.91 ICAM1 SELE VCAM1
14 11.82 ITGAL ITGAM ITGAX
15 11.8 ICAM1 ITGAL SH2D1A VCAM1
16 11.79 ICAM1 SELE VCAM1
17 11.78 ITGAL ITGAM ITGAX
18 11.73 ICAM1 SELE VCAM1
19 11.68 ICAM1 ITGAM ITGAX VCAM1
20 11.65 ITGAL ITGAM ITGAX
21 11.53 ITGAL ITGAM ITGAX
22
Show member pathways
11.53 ICAM1 ITGAL ITGAM ITGAX VCAM1
23
Show member pathways
11.51 ICAM1 SELE VCAM1
24 11.46 ITGAL ITGAM ITGAX
25 11.46 ITGAL ITGAM ITGAX
26 11.43 ICAM1 ITGAL ITGAM
27 11.35 ICAM1 ITGAM
28 11.34 ITGAL ITGAM ITGAX
29 11.32 ITGAL ITGAM
30 11.32 ICAM1 SELE VCAM1
31
Show member pathways
11.3 ITGAL VCAM1
32 11.25 ICAM1 ITGAL SELE VCAM1
33 11.21 ITGAL ITGAM ITGAX
34 11.18 ICAM1 ITGAL ITGAM SELE VCAM1
35 11.15 ICAM1 SELE VCAM1
36 11.1 ICAM1 ITGAL ITGAM VCAM1
37 10.82 ICAM1 VCAM1

GO Terms for Lymphocytic Vasculitis

Cellular components related to Lymphocytic Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.46 ICAM1 ITGAM ITGAX VCAM1
2 membrane raft GO:0045121 9.43 ICAM1 ITGAM SELE
3 cell surface GO:0009986 9.35 ICAM1 ITGAL ITGAM ITGAX VCAM1
4 tertiary granule membrane GO:0070821 9.32 ITGAM ITGAX
5 integrin complex GO:0008305 8.8 ITGAL ITGAM ITGAX

Biological processes related to Lymphocytic Vasculitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.8 ICAM1 ITGAL ITGAM ITGAX SELE VCAM1
2 cytokine-mediated signaling pathway GO:0019221 9.76 ICAM1 ITGAM ITGAX VCAM1
3 response to lipopolysaccharide GO:0032496 9.7 ICAM1 SELE VCAM1
4 cell-cell adhesion GO:0098609 9.67 ICAM1 ITGAL VCAM1
5 regulation of immune response GO:0050776 9.67 ICAM1 ITGAL SH2D1A VCAM1
6 integrin-mediated signaling pathway GO:0007229 9.65 ITGAL ITGAM ITGAX
7 extracellular matrix organization GO:0030198 9.65 ICAM1 ITGAL ITGAM ITGAX VCAM1
8 interferon-gamma-mediated signaling pathway GO:0060333 9.55 ICAM1 VCAM1
9 leukocyte migration GO:0050900 9.55 ICAM1 ITGAL ITGAM ITGAX SELE
10 response to ionizing radiation GO:0010212 9.54 ICAM1 VCAM1
11 leukocyte tethering or rolling GO:0050901 9.51 SELE VCAM1
12 membrane to membrane docking GO:0022614 9.43 ICAM1 VCAM1
13 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002291 9.4 ICAM1 ITGAL
14 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.26 ICAM1 ITGAL SELE VCAM1
15 leukocyte cell-cell adhesion GO:0007159 8.92 ICAM1 ITGAL SELE VCAM1

Molecular functions related to Lymphocytic Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion molecule binding GO:0050839 8.62 ITGAL VCAM1

Sources for Lymphocytic Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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