MCID: LYM006
MIFTS: 39

Lymphoepithelioma-Like Carcinoma

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Lymphoepithelioma-Like Carcinoma

MalaCards integrated aliases for Lymphoepithelioma-Like Carcinoma:

Name: Lymphoepithelioma-Like Carcinoma 12 15
Lymphoepithelial Carcinoma 12 70
Nasopharyngeal Type Undifferentiated Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5660
NCIt 50 C4107
SNOMED-CT 67 764938007
UMLS 70 C0334254

Summaries for Lymphoepithelioma-Like Carcinoma

Disease Ontology : 12 A carcinoma that is a malignant epithelial neoplasm densely infiltrated by lymphoid cells.

MalaCards based summary : Lymphoepithelioma-Like Carcinoma, also known as lymphoepithelial carcinoma, is related to eyelid carcinoma and papilloma. An important gene associated with Lymphoepithelioma-Like Carcinoma is CD274 (CD274 Molecule), and among its related pathways/superpathways are T cell receptor signaling pathway and Keratinization. The drugs Gemcitabine and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and skin, and related phenotypes are endocrine/exocrine gland and neoplasm

Wikipedia : 73 Lymphoepithelioma-like carcinoma (LELC) is a medical term referring to a histological variant of... more...

Related Diseases for Lymphoepithelioma-Like Carcinoma

Diseases related to Lymphoepithelioma-Like Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 493)
# Related Disease Score Top Affiliating Genes
1 eyelid carcinoma 30.8 KRT7 KRT20
2 papilloma 30.7 KRT8 KRT7 KRT20 EGFR
3 epstein-barr virus-associated gastric carcinoma 30.6 CDH1 CD274
4 secretory meningioma 30.6 MUC1 KRT7
5 breast lymphoma 30.6 TNFRSF8 ALK
6 in situ carcinoma 30.5 MUC1 KRT8 EGFR CDH1
7 cystitis 30.4 KRT7 KRT20 CDH1
8 chronic cystitis 30.4 KRT7 KRT20
9 keratinizing squamous cell carcinoma 30.4 KRT7 EGFR CDH1
10 sinonasal undifferentiated carcinoma 30.2 MUC1 ENO2 CEACAM3
11 epithelioid trophoblastic tumor 30.2 MUC1 KRT7 KRT18
12 cervical squamous cell carcinoma 30.2 KRT8 EGFR CDH1
13 malignant peripheral nerve sheath tumor 30.2 MUC1 KRT7 EGFR CD274
14 lymphoma 30.2 TNFRSF8 PDCD1 EGFR CD274 ALK
15 squamous cell carcinoma 30.2 MUC1 KRT7 KRT19 EGFR CDH1
16 lung benign neoplasm 30.1 KRT7 KRT20 ENO2 EGFR
17 diffuse large b-cell lymphoma 30.0 TNFRSF8 PDCD1 CD274 ALK
18 intrahepatic cholangiocarcinoma 30.0 MUC1 KRT7 KRT20 KRT19 EGFR CDH1
19 anaplastic large cell lymphoma 30.0 TNFRSF8 MUC1 ENO2 ALK
20 adenocarcinoma 29.9 MUC1 KRT7 KRT20 EGFR CDH1 ALK
21 papillary carcinoma 29.8 MUC1 KRT7 KRT20 KRT19 CDH1
22 mucoepidermoid carcinoma 29.8 MUC1 KRT7 KRT19 EGFR CDH1
23 lung squamous cell carcinoma 29.7 KRT19 EGFR CDH1 CD274 ALK
24 merkel cell carcinoma 29.7 PDCD1 MUC1 KRT8 KRT7 KRT20 ENO2
25 cholecystitis 29.7 MUC1 KRT18 EGFR CDH1
26 small cell cancer of the lung 29.6 KRT7 KRT20 KRT18 ENO2 EGFR
27 adenosquamous carcinoma 29.6 MUC1 KRT8 KRT7 KRT19 KRT18 EGFR
28 basal cell carcinoma 29.6 PDCD1 KRT8 KRT7 KRT20 KRT19 EGFR
29 esophageal cancer 29.6 PDCD1 MUC1 KRT19 EGFR CDH1 CD274
30 tubular adenocarcinoma 29.5 MUC1 KRT7 KRT20 ENO2 EGFR CDH1
31 large cell carcinoma 29.5 MUC1 KRT7 KRT20 KRT19 ENO2 EGFR
32 basaloid squamous cell carcinoma 29.5 KRT8 KRT7 KRT20 KRT19 ENO2 EGFR
33 transitional cell carcinoma 29.4 KRT8 KRT7 KRT20 KRT19 KRT18 ENO2
34 papillary adenocarcinoma 29.4 MUC1 KRT7 KRT19 CEACAM3 CDH1
35 neuroendocrine carcinoma 29.3 MUC1 KRT7 KRT20 KRT19 KRT18 ENO2
36 large cell neuroendocrine carcinoma 29.2 KRT7 KRT20 KRT18 ENO2 EGFR CD274
37 bladder cancer 29.2 PDCD1 MUC1 KRT8 KRT20 KRT19 KRT18
38 small cell carcinoma 28.9 MUC1 KRT8 KRT7 KRT20 KRT19 KRT18
39 cholangiocarcinoma 28.6 MUC1 KRT8 KRT7 KRT20 KRT19 KRT18
40 thymic carcinoma 28.4 PDCD1 MUC1 KRT7 KRT20 KRT19 KRT18
41 lung cancer 28.3 PDCD1 MUC1 KRT8 KRT7 KRT19 KRT18
42 skin carcinoma 28.1 PDCD1 KRT8 KRT7 KRT20 KRT19 KRT18
43 infiltrating bladder lymphoepithelioma-like carcinoma 11.5
44 lymphoepithelioma-like thymic carcinoma 11.4
45 cervical lymphoepithelioma-like carcinoma 11.4
46 nasopharyngeal carcinoma 10.8
47 rare tumor 10.7
48 squamous cell papilloma 10.5
49 nephrogenic adenoma 10.4 MUC1 KRT7
50 scrotum paget's disease 10.4 MUC1 KRT7

Graphical network of the top 20 diseases related to Lymphoepithelioma-Like Carcinoma:



Diseases related to Lymphoepithelioma-Like Carcinoma

Symptoms & Phenotypes for Lymphoepithelioma-Like Carcinoma

MGI Mouse Phenotypes related to Lymphoepithelioma-Like Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.56 ACP3 ALK CDH1 EGFR KRT19 PDCD1
2 neoplasm MP:0002006 9.1 ACP3 ALK CDH1 EGFR KRT19 PDCD1

Drugs & Therapeutics for Lymphoepithelioma-Like Carcinoma

Drugs for Lymphoepithelioma-Like Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 2 95058-81-4 60750
2
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
3 Immunologic Factors Phase 2
4 Immunosuppressive Agents Phase 2
5 Anti-Infective Agents Phase 2
6 Antiviral Agents Phase 2
7 Antimetabolites Phase 2
8 Liver Extracts
9 Immunoglobulins
10 Antibodies
11 Antibodies, Monoclonal

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Exploratory Clinical Trial of Sintilimab Combined With Gemcitabine/Carboplatin Regimen in the Treatment of Advanced Primary Pulmonary Lymphoepithelioma-like Carcinoma(LELC) Recruiting NCT04312204 Phase 2 Sintilimab combined with Gemcitabine and Carboplatin
2 A Multi-center, Retrospective Analysis of Clinical Character, Outcome and Prognosis of Lymphoepithelioma-like Carcinoma Recruiting NCT04614818
3 A Exploratory Clinical Study on PD-1 Monoclonal Antibody in Pre-treated Lymphoepithelioma-like Carcinoma Not yet recruiting NCT04430166 PD-1 monoclonal antibody

Search NIH Clinical Center for Lymphoepithelioma-Like Carcinoma

Genetic Tests for Lymphoepithelioma-Like Carcinoma

Anatomical Context for Lymphoepithelioma-Like Carcinoma

MalaCards organs/tissues related to Lymphoepithelioma-Like Carcinoma:

40
Breast, Lung, Skin, Cervix, Salivary Gland, Thymus, Colon

Publications for Lymphoepithelioma-Like Carcinoma

Articles related to Lymphoepithelioma-Like Carcinoma:

(show top 50) (show all 764)
# Title Authors PMID Year
1
Indicators for Malignant Transformation in Patients With Lymphoepithelial Lesion. 61
33152327 2021
2
A case of Epstein-Barr virus-associated lymphoepithelioma-like carcinoma of the colon. 61
33792098 2021
3
Lymphoepithelioma-like carcinoma of the vagina: A rare case report and review of the literature. 61
33650156 2021
4
Primary pulmonary lymphoepithelioma-like carcinoma: A case report of pathological complete response (pCR) by neoadjuvant treatment. 61
33725970 2021
5
Lymphoepithelial Carcinoma of Salivary Glands. 61
33526225 2021
6
Clinicopathological and prognostic analyses of 86 resected pulmonary lymphoepithelioma-like carcinomas. 61
33125732 2021
7
Primary pulmonary lymphoepithelioma-like carcinoma with positive expression of Epstein-Barr virus and PD-L1: A case report. 61
33529823 2021
8
Pulmonary lymphoepithelioma-like carcinoma: A case report with emphasis on computed tomography findings. 61
33592895 2021
9
Molecular characteristics of primary pulmonary lymphoepithelioma-like carcinoma based on integrated genomic analyses. 61
33414372 2021
10
Concurrent chemoradiation in locally advanced primary middle ear lymphoepithelial carcinoma: an effective treatment modality case report. 61
33407879 2021
11
Pulmonary Lymphoepithelioma-Like Carcinoma Treated with Immunotherapy or Chemotherapy: A Single Institute Experience. 61
33628032 2021
12
Penile Lymphoepithelioma-Like Carcinoma: A Rare Case With PD-L1 Expression. 61
33455515 2021
13
Clinicopathological characteristics and prognostic analysis of lymphoepithelial carcinoma of salivary gland: a population-based study. 61
33447549 2020
14
Surgical treatment of Epstein-Barr virus-associated lymphoepithelioma-like carcinoma occurring in both the posterior mediastinum and liver: Case report. 61
33350736 2020
15
Lymphoepithelial Carcinoma of Salivary Gland EBV-association in Endemic versus Non-Endemic Patients: A Report of 16 Cases. 61
32462279 2020
16
Lymphoepithelioma-like carcinoma of the lung: a rare case report and review of the literature. 61
33448744 2020
17
SSTR2a is constantly expressed in lymphoepithelioma-like carcinoma with squamous differentiation other than that with glandular differentiation. 61
33132215 2020
18
Primary pulmonary lymphoepithelioma-like carcinoma accompanied by hypertrophic pulmonary osteoarthropathy in a non-epidemic region: a case report and literature review. 61
33161786 2020
19
Rare Case of Lymphoepithelioma-like Carcinoma of the Eyelid. 61
33099565 2020
20
Computed tomography-based differentiation of primary pulmonary lymphoepithelioma-like carcinoma and small-cell lung cancer. 61
33017126 2020
21
Eight-year follow-up of locally advanced lymphoepithelioma-like carcinoma at upper urinary tract: A case report. 61
33083411 2020
22
Coexisting TIF1γ-positive Primary Pulmonary Lymphoepithelioma-like Carcinoma and Anti-TIF1γ Antibody-positive Dermatomyositis. 61
32581161 2020
23
Tumors of Atypical Carcinoma of the Parotid Gland and Papillary Thyroid Carcinoma: A Case Report. 61
32963922 2020
24
Lymphoepithelioma-like carcinoma in liver not associated with Epstein-Barr virus: a report of 3 cases and literature review. 61
32967689 2020
25
A Rare Case of Sinonasal Lymphoepithelial Carcinoma Presented With Clinically Stage IV Disease. 61
32998538 2020
26
Paraneoplastic cerebellar degeneration associated with anti-protein kinase Cgamma antibodies in a Chinese patient. 61
33217719 2020
27
Lymphoepithelial Carcinoma of Larynx and Hypopharynx: A Rare Clinicopathological Entity. 61
32867094 2020
28
Clinicopathological Characteristics and Prognosis of Nasopharyngeal Lymphoepithelial Carcinoma: A Population-Based Retrospective Study. 61
32865186 2020
29
Overcoming resistance to anti-PD-1 immunotherapy in lymphoepithelioma-like carcinoma: A case report and review of the literature. 61
32623076 2020
30
Primary pulmonary lymphoepithelioma-like carcinoma is characterized by high PD-L1 expression, but low tumor mutation burden. 61
32703503 2020
31
A case of poorly differentiated adenocarcinoma with lymphoid stroma originated in the ascending colon diagnosed as lymphoepithelioma-like carcinoma. 61
31845183 2020
32
Simultaneous upper and lower urinary tract invasive Lymphoepithelioma-like carcinoma with programmed death-ligand 1 full expression on combined positive score. 61
32322521 2020
33
Distinct Molecular Landscape of Epstein-Barr Virus Associated Pulmonary Lymphoepithelioma-Like Carcinoma Revealed by Genomic Sequencing. 61
32726920 2020
34
What Is the Significance of Variant Histology in Urothelial Carcinoma? 61
31530497 2020
35
The Clinicopathological Features and Genetic Alterations in Epstein-Barr Virus-Associated Gastric Cancer Patients after Curative Surgery. 61
32531970 2020
36
Treatment of pembrolizumab and chemotherapy results in pulmonary lymphoepithelioma-like carcinoma progression through harboring secondary amplification of PI3KCA and IL-7R. 61
32331790 2020
37
Regarding the "Is Surgery an Inevitable Treatment for Advanced Salivary Lymphoepithelial Carcinoma? Three Case Reports". 61
32538670 2020
38
Rare primary lymphoepithelioma-like carcinoma of the renal pelvis. 61
32420309 2020
39
Is Surgery an Inevitable Treatment for Advanced Salivary Lymphoepithelial Carcinoma? Three Case Reports. 61
32380853 2020
40
CD56+ lymphoepithelioma-like carcinoma of the lung: A case report and literature review. 61
32337200 2020
41
[Gastric EB virus-associated lymphoepithelioma-like carcinoma with B-lymphocyte monoclonal hyperplasia: report of a case]. 61
32268681 2020
42
A multicenter analysis of genomic profiles and PD-L1 expression of primary lymphoepithelioma-like carcinoma of the lung. 61
31659278 2020
43
[Clinical Analysis of Primary Pulmonary Lymphoepithelioma-like Carcinoma in 8 Patients]. 61
32209185 2020
44
Lymphoepithelioma-like carcinoma of the duodenum: a very infrequent tumor. 61
32022569 2020
45
Primary pulmonary lymphoepithelioma-like carcinoma. 61
32146584 2020
46
Lymphoepithelioma-like carcinoma of the upper urinary tract: A systematic review of case reports. 61
32149060 2020
47
Low frequency of mutation of epidermal growth factor receptor (EGFR) and arrangement of anaplastic lymphoma kinase (ALK) in primary pulmonary lymphoepithelioma-like carcinoma. 61
31794146 2020
48
A Phase II Trial of Pembrolizumab and Vorinostat in Recurrent Metastatic Head and Neck Squamous Cell Carcinomas and Salivary Gland Cancer. 61
31796519 2020
49
Thymic Squamous Cell Carcinoma: A Population-Based Surveillance, Epidemiology, and End Result Analysis. 61
33415074 2020
50
Partial absence of PD-1 expression by tumor-infiltrating EBV-specific CD8+ T cells in EBV-driven lymphoepithelioma-like carcinoma. 61
32995000 2020

Variations for Lymphoepithelioma-Like Carcinoma

Expression for Lymphoepithelioma-Like Carcinoma

Search GEO for disease gene expression data for Lymphoepithelioma-Like Carcinoma.

Pathways for Lymphoepithelioma-Like Carcinoma

GO Terms for Lymphoepithelioma-Like Carcinoma

Cellular components related to Lymphoepithelioma-Like Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.93 TNFRSF8 PDCD1 MUC1 KRT19 KRT18 ENO2
2 keratin filament GO:0045095 9.5 KRT8 KRT7 KRT18
3 cell periphery GO:0071944 9.43 KRT8 KRT19 KRT18
4 costamere GO:0043034 9.4 KRT8 KRT19
5 extracellular exosome GO:0070062 9.4 TNFRSF8 RPL22 MUC1 KRT8 KRT7 KRT19
6 dystrophin-associated glycoprotein complex GO:0016010 9.37 KRT8 KRT19
7 intermediate filament GO:0005882 9.35 KRT8 KRT7 KRT20 KRT19 KRT18

Biological processes related to Lymphoepithelioma-Like Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.65 KRT8 KRT7 KRT19 KRT18 EGFR
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.54 TNFRSF8 KRT8 KRT18
3 keratinization GO:0031424 9.35 KRT8 KRT7 KRT20 KRT19 KRT18
4 hepatocyte apoptotic process GO:0097284 9.32 KRT8 KRT18
5 cell differentiation involved in embryonic placenta development GO:0060706 9.16 KRT8 KRT19
6 cornification GO:0070268 9.02 KRT8 KRT7 KRT20 KRT19 KRT18

Molecular functions related to Lymphoepithelioma-Like Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.53 TNFRSF8 RPL22 PDCD1 MUC1 KRT8 KRT7

Sources for Lymphoepithelioma-Like Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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