MCID: LYM018
MIFTS: 26

Lymphoepithelioma-Like Thymic Carcinoma

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Lymphoepithelioma-Like Thymic Carcinoma

MalaCards integrated aliases for Lymphoepithelioma-Like Thymic Carcinoma:

Name: Lymphoepithelioma-Like Thymic Carcinoma 12 15
Lymphoepithelioma-Like Carcinoma of the Thymus 12
Thymic Lymphoepithelioma-Like Carcinoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:7599
NCIt 50 C7998
UMLS 70 C0279706

Summaries for Lymphoepithelioma-Like Thymic Carcinoma

MalaCards based summary : Lymphoepithelioma-Like Thymic Carcinoma, also known as lymphoepithelioma-like carcinoma of the thymus, is related to thymic carcinoma and keratinizing squamous cell carcinoma, and has symptoms including fatigue, fever and dyspnea. An important gene associated with Lymphoepithelioma-Like Thymic Carcinoma is CD5 (CD5 Molecule), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. Affiliated tissues include thymus.

Related Diseases for Lymphoepithelioma-Like Thymic Carcinoma

Diseases related to Lymphoepithelioma-Like Thymic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 thymic carcinoma 31.0 KIT CD5
2 keratinizing squamous cell carcinoma 30.1 NUTM1 KRT5
3 rare tumor 10.4
4 nephrotic syndrome 10.3
5 lymphoepithelioma-like carcinoma 10.2
6 polymyositis 10.1
7 neutropenia 10.1
8 paraneoplastic syndromes 10.1
9 thymic epithelial tumor 10.1 KIT CD5
10 spindle epithelial tumor with thymus-like differentiation tumor 10.1 KIT CD5
11 thymoma 10.1 KIT CD5
12 type c thymoma 10.1 KIT CD5
13 extragonadal seminoma 10.1 NUTM1 KIT
14 nut midline carcinoma 10.0 NUTM1 BRD4
15 spindle cell sarcoma 10.0 NUTM1 KIT
16 thymus basaloid carcinoma 9.9 KRT5 CD5
17 spindle cell thymoma 9.9 KRT5 CD5
18 leukocyte disease 9.9 KIT CD5
19 breast osteosarcoma 9.9 KRT5 CD5
20 eccrine sweat gland cancer 9.9 NUTM1 KRT5
21 eccrine acrospiroma 9.9 NUTM1 KRT5
22 eccrine sweat gland neoplasm 9.9 NUTM1 KRT5
23 endobronchial lipoma 9.9 NUTM1 KRT5
24 trachea adenoid cystic carcinoma 9.9 KRT5 KIT
25 ceruminous adenocarcinoma 9.9 KRT5 KIT
26 laryngeal small cell carcinoma 9.9 KRT5 KIT
27 liver fibroma 9.9 KRT5 KIT
28 blood platelet disease 9.9 KIT CD5
29 colon leiomyosarcoma 9.9 KRT5 KIT
30 mediastinal cancer 9.9 NUTM1 KIT CD5
31 trachea carcinoma 9.9 KRT5 KIT
32 mucinous stomach adenocarcinoma 9.8 KRT5 KIT
33 breast malignant phyllodes tumor 9.8 KRT5 KIT
34 liver leiomyosarcoma 9.8 KRT5 KIT
35 nasal cavity cancer 9.8 NUTM1 KRT5
36 lung leiomyosarcoma 9.8 KRT5 KIT
37 esophagus sarcoma 9.8 KRT5 KIT
38 uterus leiomyosarcoma 9.8 KRT5 KIT
39 uterine corpus sarcoma 9.8 KRT5 KIT
40 synchronous bilateral breast carcinoma 9.8 KRT5 KIT
41 cribriform carcinoma 9.8 KRT5 KIT
42 heart cancer 9.8 KRT5 KIT
43 bladder sarcoma 9.8 KRT5 KIT
44 dowling-degos disease 1 9.8 KRT5 KIT
45 mixed cell type cancer 9.8 KRT5 KIT
46 tonsil cancer 9.8 KRT5 KIT
47 oropharynx cancer 9.7 KRT5 KIT
48 salivary gland disease 9.7 KRT5 KIT
49 adenosquamous carcinoma 9.7 KRT5 KIT
50 myeloma, multiple 9.7 KIT CD5 BRD4

Graphical network of the top 20 diseases related to Lymphoepithelioma-Like Thymic Carcinoma:



Diseases related to Lymphoepithelioma-Like Thymic Carcinoma

Symptoms & Phenotypes for Lymphoepithelioma-Like Thymic Carcinoma

UMLS symptoms related to Lymphoepithelioma-Like Thymic Carcinoma:


fatigue; fever; dyspnea; chest pain; coughing

Drugs & Therapeutics for Lymphoepithelioma-Like Thymic Carcinoma

Search Clinical Trials , NIH Clinical Center for Lymphoepithelioma-Like Thymic Carcinoma

Genetic Tests for Lymphoepithelioma-Like Thymic Carcinoma

Anatomical Context for Lymphoepithelioma-Like Thymic Carcinoma

MalaCards organs/tissues related to Lymphoepithelioma-Like Thymic Carcinoma:

40
Thymus

Publications for Lymphoepithelioma-Like Thymic Carcinoma

Articles related to Lymphoepithelioma-Like Thymic Carcinoma:

(show all 20)
# Title Authors PMID Year
1
Total thymectomy for thymic lymphoepithelioma-like carcinoma-report of two cases. 61
31655916 2019
2
Nephrotic syndrome: first presentation of lymphoepithelioma-like thymic carcinoma. 61
30592665 2019
3
Poorly Differentiated Nonkeratinizing Squamous Cell Carcinoma of the Thymus: Clinicopathologic and Molecular Genetic Study of 25 Cases. 61
29975245 2018
4
A rare highly aggressive tumour: lymphoepithelioma-like thymic carcinoma. 61
28942409 2017
5
Response to chemotherapy with carboplatin plus albumin-bound paclitaxel in a patient with lymphoepithelioma-like thymic carcinoma: A case report. 61
27123268 2016
6
Clinical outcome of thymic lymphoepithelioma-like carcinoma: Case report of a 14-year-old male. 61
25295106 2014
7
Intrathyroidal epithelial thymoma/carcinoma showing thymus-like differentiation; comparison with thymic lymphoepithelioma-like carcinoma and a possibility of development from a multipotential stem cell. 61
23176314 2013
8
Epstein-Barr virus (EBV) associated lymphoepithelioma-like thymic carcinoma associated with paraneoplastic syndrome of polymyositis: a rare tumor with rare association. 61
19893401 2009
9
Pathophysiological lessons from rare associations of immunological disorders. 61
18853201 2009
10
Thymic lymphoepithelioma-like carcinoma mimicking primary tumor of the lung. 61
19618760 2009
11
Lymphoepithelioma-like thymic carcinoma in a 16-year-old boy with nephrotic syndrome--a case report. 61
18046582 2008
12
Thymic carcinoma in children. 61
16007580 2006
13
Multiple brain metastases from "lymphoepithelioma-like" thymic carcinoma: a combined stereotactic-radiosurgical approach. 61
11358599 2001
14
Thymic lymphoepithelioma-like carcinoma associated with thymoma in a patient with ocular myasthenia. 61
9636966 1998
15
Thymic carcinoma (report of 14 cases). 61
11360562 1997
16
EBER-1 expression in thymic carcinoma. 61
8387236 1993
17
In situ localization of Epstein-Barr virus in thymic carcinoma. 61
1323108 1992
18
Detection of Epstein-Barr virus DNA in a Japanese case of lymphoepithelioma-like thymic carcinoma. 61
1313408 1992
19
"Lymphoepithelioma-like" thymic carcinoma: another tumor related to Epstein-Barr virus? 61
2985994 1985
20
Squamous carcinoma of the thymus. 61
6694395 1984

Variations for Lymphoepithelioma-Like Thymic Carcinoma

Cosmic variations for Lymphoepithelioma-Like Thymic Carcinoma:

9 (show all 36)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM105695698 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.376T>A p.Y126N 17:7675236-7675236 3
2 COSM142891951 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.376T>A p.Y126N 17:7675236-7675236 3
3 COSM87975416 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.376T>A p.Y126N 17:7675236-7675236 3
4 COSM142627127 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.259T>A p.Y87N 17:7675236-7675236 3
5 COSM121944830 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.-21T>A p.? 17:7675236-7675236 3
6 COSM106116533 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.376T>A p.Y126N 17:7675236-7675236 3
7 COSM144072853 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.343T>A p.Y115N 17:7675236-7675236 3
8 COSM144363948 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.259T>A p.Y87N 17:7675236-7675236 3
9 COSM122332176 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.-21T>A p.? 17:7675236-7675236 3
10 COSM93250189 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.376T>A p.Y126N 17:7675236-7675236 3
11 COSM145076506 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.259T>A p.Y87N 17:7675236-7675236 3
12 COSM122804157 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.-21T>A p.? 17:7675236-7675236 3
13 COSM144718880 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.259T>A p.Y87N 17:7675236-7675236 3
14 COSM144140974 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.-102T>A p.? 17:7675236-7675236 3
15 COSM112319052 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.376T>A p.Y126N 17:7675236-7675236 3
16 COSM143214478 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.-102T>A p.? 17:7675236-7675236 3
17 COSM143433019 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.259T>A p.Y87N 17:7675236-7675236 3
18 COSM111826108 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.376T>A p.Y126N 17:7675236-7675236 3
19 COSM144005441 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.-102T>A p.? 17:7675236-7675236 3
20 COSM103083119 SMAD4 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.1081C>T p.R361C 18:51065548-51065548 3
21 COSM139771670 SMAD4 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.793C>T p.R265C 18:51065548-51065548 3
22 COSM91380576 SMAD4 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.1081C>T p.R361C 18:51065548-51065548 3
23 COSM88596522 PREX2 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.107G>T p.R36L 8:67952501-67952501 3
24 COSM88408638 NOTCH2 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.3359G>A p.C1120Y 1:119937445-119937445 3
25 COSM87667907 KMT2D thymus,NS,thymic carcinoma,undifferentiated carcinoma c.12634C>T p.R4212W 12:49032071-49032071 3
26 COSM88314740 KIT thymus,NS,thymic carcinoma,undifferentiated carcinoma c.1657T>A p.Y553N 4:54727425-54727425 3
27 COSM132270273 KDM6A thymus,NS,thymic carcinoma,undifferentiated carcinoma c.2768C>T p.A923V 23:45078488-45078488 3
28 COSM101719617 KDM6A thymus,NS,thymic carcinoma,undifferentiated carcinoma c.2870C>T p.A957V 23:45078488-45078488 3
29 COSM145420036 KDM6A thymus,NS,thymic carcinoma,undifferentiated carcinoma c.*1915C>T p.? 23:45078488-45078488 3
30 COSM143359668 KDM6A thymus,NS,thymic carcinoma,undifferentiated carcinoma c.3005C>T p.A1002V 23:45078488-45078488 3
31 COSM102181889 KDM6A thymus,NS,thymic carcinoma,undifferentiated carcinoma c.2921C>T p.A974V 23:45078488-45078488 3
32 COSM132025397 KDM6A thymus,NS,thymic carcinoma,undifferentiated carcinoma c.2714C>T p.A905V 23:45078488-45078488 3
33 COSM85170206 IL7R thymus,NS,thymic carcinoma,undifferentiated carcinoma c.537+1G>T p.? 5:35871214-35871214 3
34 COSM121730466 IL7R thymus,NS,thymic carcinoma,undifferentiated carcinoma c.537+1G>T p.? 5:35871214-35871214 3
35 COSM143857324 FAT1 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.12712A>G p.K4238E 4:186596834-186596834 3
36 COSM110448949 FAT1 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.12706A>G p.K4236E 4:186596834-186596834 3

Expression for Lymphoepithelioma-Like Thymic Carcinoma

Search GEO for disease gene expression data for Lymphoepithelioma-Like Thymic Carcinoma.

Pathways for Lymphoepithelioma-Like Thymic Carcinoma

Pathways related to Lymphoepithelioma-Like Thymic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.02 KIT CD5
2 10.62 KIT CD5

GO Terms for Lymphoepithelioma-Like Thymic Carcinoma

Sources for Lymphoepithelioma-Like Thymic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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