MCID: LYM018
MIFTS: 28

Lymphoepithelioma-Like Thymic Carcinoma

Categories: Cancer diseases, Immune diseases
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Aliases & Classifications for Lymphoepithelioma-Like Thymic Carcinoma

MalaCards integrated aliases for Lymphoepithelioma-Like Thymic Carcinoma:

Name: Lymphoepithelioma-Like Thymic Carcinoma 11 14
Lymphoepithelioma-Like Carcinoma of the Thymus 11
Thymic Lymphoepithelioma-Like Carcinoma 71

Classifications:



External Ids:

Disease Ontology 11 DOID:7599
NCIt 49 C7998
UMLS 71 C0279706

Summaries for Lymphoepithelioma-Like Thymic Carcinoma

MalaCards based summary: Lymphoepithelioma-Like Thymic Carcinoma, also known as lymphoepithelioma-like carcinoma of the thymus, is related to keratinizing squamous cell carcinoma and thymic carcinoma, and has symptoms including fatigue, fever and dyspnea. An important gene associated with Lymphoepithelioma-Like Thymic Carcinoma is CD5 (CD5 Molecule), and among its related pathways/superpathways is Hematopoietic Stem Cells and Lineage-specific Markers. Affiliated tissues include thymus, lung and brain, and related phenotypes are growth/size/body region and digestive/alimentary

Related Diseases for Lymphoepithelioma-Like Thymic Carcinoma

Diseases related to Lymphoepithelioma-Like Thymic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 keratinizing squamous cell carcinoma 30.2 NUTM1 KRT5
2 thymic carcinoma 30.2 NUTM1 KRT5 KIT CD5
3 lymphoepithelioma-like carcinoma 29.9 NUTM1 KRT5 KIT
4 rare tumor 10.4
5 nephrotic syndrome 10.3
6 polymyositis 10.1
7 neutropenia 10.1
8 paraneoplastic syndromes 10.1
9 thymus clear cell carcinoma 10.1 KIT CD5
10 thymoma 10.1 KIT CD5
11 spindle epithelial tumor with thymus-like differentiation tumor 10.1 KIT CD5
12 thymus basaloid carcinoma 10.0 KRT5 CD5
13 combined thymoma 10.0 KRT5 CD5
14 spindle cell thymoma 10.0 KRT5 CD5
15 acute biphenotypic leukemia 10.0 KIT CD5
16 sinonasal undifferentiated carcinoma 10.0 NUTM1 KRT5
17 myoepithelial carcinoma 10.0 NUTM1 KRT5
18 eccrine acrospiroma 10.0 NUTM1 KRT5
19 eccrine sweat gland cancer 10.0 NUTM1 KRT5
20 laryngeal adenoid cystic carcinoma 10.0 KRT5 KIT
21 eccrine sweat gland neoplasm 10.0 NUTM1 KRT5
22 spindle cell sarcoma 10.0 NUTM1 KIT
23 ceruminous adenocarcinoma 10.0 KRT5 KIT
24 adult type testicular granulosa cell tumor 10.0 KRT5 KIT
25 eccrine porocarcinoma 10.0 NUTM1 KRT5
26 cutaneous leiomyosarcoma 10.0 KRT5 KIT
27 ureter small cell carcinoma 10.0 KRT5 KIT
28 breast adenoid cystic carcinoma 10.0 KRT5 KIT
29 paranasal sinus cancer 10.0 NUTM1 KRT5
30 breast leiomyosarcoma 10.0 KRT5 KIT
31 breast sarcoma 10.0 KRT5 KIT
32 epithelial-myoepithelial carcinoma 10.0 KRT5 KIT
33 endobronchial lipoma 10.0 NUTM1 KRT5
34 breast malignant phyllodes tumor 10.0 KRT5 KIT
35 hidradenoma 10.0 NUTM1 KRT5
36 dowling-degos disease 1 9.9 KRT5 KIT
37 nasal cavity cancer 9.9 NUTM1 KRT5
38 anus basaloid carcinoma 9.9 KRT5 KIT
39 laryngeal small cell carcinoma 9.9 KRT5 KIT
40 synchronous bilateral breast carcinoma 9.9 KRT5 KIT
41 heart cancer 9.9 KRT5 KIT
42 ectopic thymus 9.9 KRT8 CD5
43 salivary gland adenoid cystic carcinoma 9.9 KRT5 KIT
44 mixed cell type cancer 9.9 KRT5 KIT
45 salivary gland disease 9.9 KRT5 KIT
46 thymus adenocarcinoma 9.9 NUTM1 KIT CD5
47 mediastinum sarcoma 9.9 NUTM1 KIT CD5
48 mediastinal cancer 9.9 NUTM1 KIT CD5
49 prostate stromal sarcoma 9.9 KRT8 KIT
50 oropharynx cancer 9.9 KRT5 KIT

Graphical network of the top 20 diseases related to Lymphoepithelioma-Like Thymic Carcinoma:



Diseases related to Lymphoepithelioma-Like Thymic Carcinoma

Symptoms & Phenotypes for Lymphoepithelioma-Like Thymic Carcinoma

UMLS symptoms related to Lymphoepithelioma-Like Thymic Carcinoma:


fatigue; fever; dyspnea; chest pain; coughing

MGI Mouse Phenotypes related to Lymphoepithelioma-Like Thymic Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.43 CD5 CMIP KIT KRT5 KRT8 NUTM1
2 digestive/alimentary MP:0005381 8.92 CMIP KIT KRT5 KRT8

Drugs & Therapeutics for Lymphoepithelioma-Like Thymic Carcinoma

Search Clinical Trials, NIH Clinical Center for Lymphoepithelioma-Like Thymic Carcinoma

Genetic Tests for Lymphoepithelioma-Like Thymic Carcinoma

Anatomical Context for Lymphoepithelioma-Like Thymic Carcinoma

Organs/tissues related to Lymphoepithelioma-Like Thymic Carcinoma:

MalaCards : Thymus, Lung, Brain

Publications for Lymphoepithelioma-Like Thymic Carcinoma

Articles related to Lymphoepithelioma-Like Thymic Carcinoma:

(show all 17)
# Title Authors PMID Year
1
Successful multimodal treatment of stage IV lymphoepithelioma-like thymic carcinoma. 62
35414821 2022
2
Nephrotic syndrome: first presentation of lymphoepithelioma-like thymic carcinoma. 62
30592665 2019
3
Expression of PD-L1/PD-1 in lymphoepithelioma-like carcinoma of the thymus. 62
29973653 2018
4
Poorly Differentiated Nonkeratinizing Squamous Cell Carcinoma of the Thymus: Clinicopathologic and Molecular Genetic Study of 25 Cases. 62
29975245 2018
5
A rare highly aggressive tumour: lymphoepithelioma-like thymic carcinoma. 62
28942409 2017
6
Response to chemotherapy with carboplatin plus albumin-bound paclitaxel in a patient with lymphoepithelioma-like thymic carcinoma: A case report. 62
27123268 2016
7
[Lung metastasis of thymic carcinoma twelve years after complete resection of primary disease]. 62
19999093 2009
8
Epstein-Barr virus (EBV) associated lymphoepithelioma-like thymic carcinoma associated with paraneoplastic syndrome of polymyositis: a rare tumor with rare association. 62
19893401 2009
9
Pathophysiological lessons from rare associations of immunological disorders. 62
18853201 2009
10
Lymphoepithelioma-like thymic carcinoma in a 16-year-old boy with nephrotic syndrome--a case report. 62
18046582 2008
11
Thymic carcinoma in children. 62
16007580 2006
12
Multiple brain metastases from "lymphoepithelioma-like" thymic carcinoma: a combined stereotactic-radiosurgical approach. 62
11358599 2001
13
Thymic carcinoma (report of 14 cases). 62
11360562 1997
14
EBER-1 expression in thymic carcinoma. 62
8387236 1993
15
Detection of Epstein-Barr virus DNA in a Japanese case of lymphoepithelioma-like thymic carcinoma. 62
1313408 1992
16
"Lymphoepithelioma-like" thymic carcinoma: another tumor related to Epstein-Barr virus? 62
2985994 1985
17
Squamous carcinoma of the thymus. 62
6694395 1984

Variations for Lymphoepithelioma-Like Thymic Carcinoma

Cosmic variations for Lymphoepithelioma-Like Thymic Carcinoma:

8 (show all 36)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM105695698 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.376T>A p.Y126N 17:7675236-7675236 2
2 COSM142891951 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.376T>A p.Y126N 17:7675236-7675236 2
3 COSM87975416 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.376T>A p.Y126N 17:7675236-7675236 2
4 COSM142627127 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.259T>A p.Y87N 17:7675236-7675236 2
5 COSM121944830 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.-21T>A p.? 17:7675236-7675236 2
6 COSM106116533 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.376T>A p.Y126N 17:7675236-7675236 2
7 COSM144072853 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.343T>A p.Y115N 17:7675236-7675236 2
8 COSM144363948 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.259T>A p.Y87N 17:7675236-7675236 2
9 COSM122332176 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.-21T>A p.? 17:7675236-7675236 2
10 COSM93250189 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.376T>A p.Y126N 17:7675236-7675236 2
11 COSM145076506 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.259T>A p.Y87N 17:7675236-7675236 2
12 COSM122804157 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.-21T>A p.? 17:7675236-7675236 2
13 COSM144718880 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.259T>A p.Y87N 17:7675236-7675236 2
14 COSM144140974 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.-102T>A p.? 17:7675236-7675236 2
15 COSM112319052 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.376T>A p.Y126N 17:7675236-7675236 2
16 COSM143214478 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.-102T>A p.? 17:7675236-7675236 2
17 COSM143433019 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.259T>A p.Y87N 17:7675236-7675236 2
18 COSM111826108 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.376T>A p.Y126N 17:7675236-7675236 2
19 COSM144005441 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.-102T>A p.? 17:7675236-7675236 2
20 COSM103083119 SMAD4 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.1081C>T p.R361C 18:51065548-51065548 2
21 COSM139771670 SMAD4 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.793C>T p.R265C 18:51065548-51065548 2
22 COSM91380576 SMAD4 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.1081C>T p.R361C 18:51065548-51065548 2
23 COSM88596522 PREX2 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.107G>T p.R36L 8:67952501-67952501 2
24 COSM88408638 NOTCH2 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.3359G>A p.C1120Y 1:119937445-119937445 2
25 COSM87667907 KMT2D thymus,NS,thymic carcinoma,undifferentiated carcinoma c.12634C>T p.R4212W 12:49032071-49032071 2
26 COSM88314740 KIT thymus,NS,thymic carcinoma,undifferentiated carcinoma c.1657T>A p.Y553N 4:54727425-54727425 2
27 COSM132270273 KDM6A thymus,NS,thymic carcinoma,undifferentiated carcinoma c.2768C>T p.A923V 23:45078488-45078488 2
28 COSM101719617 KDM6A thymus,NS,thymic carcinoma,undifferentiated carcinoma c.2870C>T p.A957V 23:45078488-45078488 2
29 COSM145420036 KDM6A thymus,NS,thymic carcinoma,undifferentiated carcinoma c.*1915C>T p.? 23:45078488-45078488 2
30 COSM143359668 KDM6A thymus,NS,thymic carcinoma,undifferentiated carcinoma c.3005C>T p.A1002V 23:45078488-45078488 2
31 COSM102181889 KDM6A thymus,NS,thymic carcinoma,undifferentiated carcinoma c.2921C>T p.A974V 23:45078488-45078488 2
32 COSM132025397 KDM6A thymus,NS,thymic carcinoma,undifferentiated carcinoma c.2714C>T p.A905V 23:45078488-45078488 2
33 COSM85170206 IL7R thymus,NS,thymic carcinoma,undifferentiated carcinoma c.537+1G>T p.? 5:35871214-35871214 2
34 COSM121730466 IL7R thymus,NS,thymic carcinoma,undifferentiated carcinoma c.537+1G>T p.? 5:35871214-35871214 2
35 COSM143857324 FAT1 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.12712A>G p.K4238E 4:186596834-186596834 2
36 COSM110448949 FAT1 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.12706A>G p.K4236E 4:186596834-186596834 2

Expression for Lymphoepithelioma-Like Thymic Carcinoma

Search GEO for disease gene expression data for Lymphoepithelioma-Like Thymic Carcinoma.

Pathways for Lymphoepithelioma-Like Thymic Carcinoma

Pathways related to Lymphoepithelioma-Like Thymic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.69 KIT CD5

GO Terms for Lymphoepithelioma-Like Thymic Carcinoma

Biological processes related to Lymphoepithelioma-Like Thymic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament organization GO:0045109 8.92 KRT8 KRT5

Molecular functions related to Lymphoepithelioma-Like Thymic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of skin epidermis GO:0030280 8.92 KRT8 KRT5

Sources for Lymphoepithelioma-Like Thymic Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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