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MCID: LYM018
MIFTS: 34

Lymphoepithelioma-Like Thymic Carcinoma

Categories: Cancer diseases, Endocrine diseases, Immune diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Lymphoepithelioma-Like Thymic Carcinoma

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MalaCards integrated aliases for Lymphoepithelioma-Like Thymic Carcinoma:

Name: Lymphoepithelioma-Like Thymic Carcinoma 12 15
Lymphoepithelioma-Like Carcinoma of the Thymus 12
Thymic Lymphoepithelioma-Like Carcinoma 73

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:7599
NCIt 50 C7998
UMLS 73 C0279706
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Summaries for Lymphoepithelioma-Like Thymic Carcinoma

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MalaCards based summary : Lymphoepithelioma-Like Thymic Carcinoma, also known as lymphoepithelioma-like carcinoma of the thymus, is related to thymus cancer and lymphoepithelioma-like carcinoma, and has symptoms including fever, fatigue and dyspnea. An important gene associated with Lymphoepithelioma-Like Thymic Carcinoma is CD5 (CD5 Molecule), and among its related pathways/superpathways are Cytoskeletal Signaling and Central carbon metabolism in cancer. Affiliated tissues include thymus, lung and bone, and related phenotypes are Dynamic nuclei (hole, folded or small irregular) and growth/size/body region

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Related Diseases for Lymphoepithelioma-Like Thymic Carcinoma

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Diseases related to Lymphoepithelioma-Like Thymic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 thymus cancer 30.3 CD274 CD5 KIT KRT5
2 lymphoepithelioma-like carcinoma 30.3 CD274 KRT18 KRT5
3 epidural neoplasm 10.2 CD5 KRT5
4 schneiderian carcinoma 10.2 KRT18 KRT5
5 cervical clear cell adenocarcinoma 10.2 KRT18 KRT5
6 odontoma 10.2 KRT18 KRT5
7 intraneural perineurioma 10.2 KRT18 KRT5
8 malignant biphasic mesothelioma 10.2 EPCAM KRT5
9 nephrotic syndrome 10.1
10 polymyositis 10.1
11 colon lymphoma 10.1 CD5 CDKN2A
12 inverted transitional papilloma 10.1 CDKN2A KRT5
13 optic nerve sheath meningioma 10.1 CDKN2A KRT5
14 primary cutaneous amyloidosis 10.1 KRT18 KRT5
15 keratinizing squamous cell carcinoma 10.1 CDKN2A KRT5
16 papillary thymic adenocarcinoma 10.1 CD5 TG
17 anal canal squamous cell carcinoma 10.1 CDKN2A KRT5
18 nasal cavity squamous cell carcinoma 10.1 CDKN2A KRT5
19 periosteal chondrosarcoma 10.1 CDKN2A IDH1
20 retinal hemangioblastoma 10.1 CD274 KRT18
21 anus cancer 10.1 CDKN2A KRT5
22 fetal adenoma 10.1 CD5 TG
23 optic nerve neoplasm 10.1 CDKN2A KRT5
24 lymphohistiocytoid mesothelioma 10.1 CDKN2A EPCAM
25 breast cystic hypersecretory carcinoma 10.1 KRT5 TG
26 bile duct adenocarcinoma 10.1 EPCAM IDH1
27 pre-malignant neoplasm 10.1 CDKN2A KRT5
28 cystadenofibroma 10.1 KRT5 TG
29 sweat gland cancer 10.1 KRT18 KRT5
30 in situ carcinoma 10.1 CDKN2A KRT5
31 breast secretory carcinoma 10.1 KRT5 TG
32 cholecystitis 10.1 CDKN2A KRT18
33 thymic epithelial tumor 10.0 CD5 KIT
34 papillary thyroid microcarcinoma 10.0 EPCAM TG
35 squamous cell papilloma 10.0 CD274 CDKN2A
36 mixed type thymoma 10.0 CD5 KIT
37 mediastinal cancer 10.0 CD5 KIT
38 gallbladder sarcoma 10.0 KIT KRT18
39 supratentorial cancer 10.0 CDKN2A IDH1
40 epstein-barr virus-associated gastric carcinoma 10.0 CD274 CDKN2A
41 ceruminoma 10.0 KIT KRT5
42 warthin tumor 10.0 KIT KRT18
43 cerebrum cancer 10.0 CDKN2A IDH1
44 central nervous system lymphoma 10.0 CD274 CDKN2A
45 thymus gland disease 10.0 CD5 KIT
46 dowling-degos disease 1 10.0 KIT KRT5
47 oncocytoma 10.0 KIT KRT18
48 undifferentiated pleomorphic sarcoma 10.0 IDH1 KIT
49 ovarian brenner tumor 10.0 KIT KRT18
50 pharynx cancer 10.0 CDKN2A KIT

Graphical network of the top 20 diseases related to Lymphoepithelioma-Like Thymic Carcinoma:



Diseases related to Lymphoepithelioma-Like Thymic Carcinoma
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Symptoms & Phenotypes for Lymphoepithelioma-Like Thymic Carcinoma

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UMLS symptoms related to Lymphoepithelioma-Like Thymic Carcinoma:


fever, fatigue, dyspnea, chest pain, coughing

GenomeRNAi Phenotypes related to Lymphoepithelioma-Like Thymic Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Dynamic nuclei (hole, folded or small irregular) GR00257-A-1 9.1 CD5 CDKN2A IDH1 KRT18 KRT5 TG

MGI Mouse Phenotypes related to Lymphoepithelioma-Like Thymic Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.87 CDKN2A EPCAM IDH1 KIT KRT18 KRT5
2 hematopoietic system MP:0005397 9.8 CD274 CD5 CDKN2A EPCAM IDH1 KIT
3 digestive/alimentary MP:0005381 9.77 CDKN2A EPCAM KIT KRT5 TG
4 immune system MP:0005387 9.7 CD274 CD5 CDKN2A EPCAM IDH1 KIT
5 integument MP:0010771 9.35 CD274 CD5 CDKN2A KIT KRT5
6 no phenotypic analysis MP:0003012 9.1 CD274 CD5 CDKN2A EPCAM KIT KRT5
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Drugs & Therapeutics for Lymphoepithelioma-Like Thymic Carcinoma

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Search Clinical Trials , NIH Clinical Center for Lymphoepithelioma-Like Thymic Carcinoma

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Genetic Tests for Lymphoepithelioma-Like Thymic Carcinoma

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Anatomical Context for Lymphoepithelioma-Like Thymic Carcinoma

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MalaCards organs/tissues related to Lymphoepithelioma-Like Thymic Carcinoma:

41
Thymus, Lung, Bone, Colon, Tonsil, Thyroid, Salivary Gland
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Publications for Lymphoepithelioma-Like Thymic Carcinoma

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Articles related to Lymphoepithelioma-Like Thymic Carcinoma:

# Title Authors Year
1
A rare highly aggressive tumour: lymphoepithelioma-like thymic carcinoma. ( 28942409 )
2017
2
Response to chemotherapy with carboplatin plus albumin-bound paclitaxel in a patient with lymphoepithelioma-like thymic carcinoma: A case report. ( 27123268 )
2016
3
Epstein-Barr virus (EBV) associated lymphoepithelioma-like thymic carcinoma associated with paraneoplastic syndrome of polymyositis: a rare tumor with rare association. ( 19893401 )
2009
4
Lymphoepithelioma-like thymic carcinoma in a 16-year-old boy with nephrotic syndrome--a case report. ( 18046582 )
2008
5
Detection of Epstein-Barr virus DNA in a Japanese case of lymphoepithelioma-like thymic carcinoma. ( 1313408 )
1992
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Variations for Lymphoepithelioma-Like Thymic Carcinoma

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Cosmic variations for Lymphoepithelioma-Like Thymic Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM44380 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.376T>A p.Y126N 17:7675236-7675236 3
2 COSM14140 SMAD4 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.1081C>T p.R361C 18:51065548-51065548 3
3 COSM6191487 PREX2 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.107G>T p.R36L 8:67952501-67952501 3
4 COSM6191489 NOTCH2 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.3359G>A p.C1120Y 1:119937445-119937445 3
5 COSM2006821 KMT2D thymus,NS,thymic carcinoma,undifferentiated carcinoma c.11824C>T p.R3942W 12:49032071-49032071 3
6 COSM133763 KIT thymus,NS,thymic carcinoma,undifferentiated carcinoma c.1657T>A p.Y553N 4:54727425-54727425 3
7 COSM6191682 KDM6A thymus,NS,thymic carcinoma,undifferentiated carcinoma c.2921C>T p.A974V 23:45078488-45078488 3
8 COSM6196604 IL7R thymus,NS,thymic carcinoma,undifferentiated carcinoma c.537+1G>T p.? 5:35871214-35871214 3
9 COSM6191486 FAT1 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.12706A>G p.K4236E 4:186596834-186596834 3
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Expression for Lymphoepithelioma-Like Thymic Carcinoma

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Search GEO for disease gene expression data for Lymphoepithelioma-Like Thymic Carcinoma.
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Pathways for Lymphoepithelioma-Like Thymic Carcinoma

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Pathways related to Lymphoepithelioma-Like Thymic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cytoskeletal Signaling 4
11.29 EPCAM KRT18 KRT5
2
Central carbon metabolism in cancer 37
10.97 IDH1 KIT
3
B Cell Development Pathways 65
10.68 CD5 KIT
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GO Terms for Lymphoepithelioma-Like Thymic Carcinoma

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Cellular components related to Lymphoepithelioma-Like Thymic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 CD274 CD5 KIT

Biological processes related to Lymphoepithelioma-Like Thymic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell costimulation GO:0031295 9.16 CD274 CD5
2 stem cell differentiation GO:0048863 8.96 EPCAM KIT
3 somatic stem cell division GO:0048103 8.62 CDKN2A KIT

Molecular functions related to Lymphoepithelioma-Like Thymic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 8.96 KRT18 KRT5
2 cadherin binding involved in cell-cell adhesion GO:0098641 8.62 EPCAM KRT18
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Sources for Lymphoepithelioma-Like Thymic Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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