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LIP
MCID: LYM004
MIFTS: 58

Lymphoid Interstitial Pneumonia (LIP)

Categories: Gastrointestinal diseases, Immune diseases, Oral diseases, Rare diseases, Respiratory diseases
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Aliases & Classifications for Lymphoid Interstitial Pneumonia

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MalaCards integrated aliases for Lymphoid Interstitial Pneumonia:

Name: Lymphoid Interstitial Pneumonia 57 11 58 43 14 71 33
Lymphocytic Interstitial Pneumonia 58 75 33
Lip Diseases 43 71
Lip Disease 11 14
Disease of Lips 11
Lip 57

Characteristics:


Inheritance:

Autosomal recessive 57

Age Of Onset:

All ages 58

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases Respiratory diseases Oral diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 31 32
ICD11: 33
Orphanet: 58  
Rare respiratory diseases


Sources

Summaries for Lymphoid Interstitial Pneumonia

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Disease Ontology 11 Lymphoid interstitial pneumonia: An idiopathic interstitial pneumonia which involves diffuse interstitial infiltration of involved areas mostly with T lymphocytes, plasma cells, and macrophages. Lymphoid hyperplasia is frequently seen. Onset is often slow with gradually increasing cough and breathlessness over 3 or more years. Fever, weight loss, chest pain, and arthralgia are occasionally found. Crackles may be detected as the disease progresses.

Lip disease: A mouth disease located in the lip.

MalaCards based summary: Lymphoid Interstitial Pneumonia, also known as lymphocytic interstitial pneumonia, is related to speech and communication disorders and potocki-shaffer syndrome, and has symptoms including oral manifestations and cheilodynia. An important gene associated with Lymphoid Interstitial Pneumonia is CD4 (CD4 Molecule), and among its related pathways/superpathways are ERK Signaling and Innate Immune System. Affiliated tissues include lip, lung and kidney, and related phenotypes are cough and failure to thrive

Orphanet: 58 A rare idiopathic interstitial pneumonia characterized by a diffuse, dense, polyclonal lymphoid cell infiltration of the pulmonary interstitium and air spaces, with high prevalence in patients with immune dysregulation. Presenting symptoms are non-specific and include dyspnea and cough. The clinical course is highly variable, ranging from spontaneous resolution to progressive, fatal respiratory failure.

Wikipedia: 75 Lymphocytic interstitial pneumonia (LIP) is a syndrome secondary to autoimmune and other... more...

More information from OMIM: 247610
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Related Diseases for Lymphoid Interstitial Pneumonia

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Diseases related to Lymphoid Interstitial Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2479)
# Related Disease Score Top Affiliating Genes
1 speech and communication disorders 31.8 TNF IL6 CRP CD4 CD19
2 potocki-shaffer syndrome 31.7 TRIM21 TNFSF13B TNF IL6 IL17A CRP
3 pneumonia 31.5 TNF MPO IL6 IL17A IFNG CRP
4 cartilage disease 31.4 TNF IL6 CRP
5 bell's palsy 31.4 TNF IL6 CRP CD8A CD4
6 facial paralysis 31.2 TNF PRTN3 IL6 CRP CD8A CD4
7 castleman disease 31.2 MTOR IL6 IFNG CRP CD4
8 apnea, obstructive sleep 31.1 TNF IL6 CRP
9 syphilis 31.1 TNF PRTN3 IL17A CRP CD8A CD4
10 lichen planus 31.1 TNF IL6 IL2 IL17A IFNG CD1A
11 otitis media 31.1 TNF MPO IL6 IL2 IL17A IFNG
12 dermatitis 31.1 TNF IL6 IL2 IL17A IFNG
13 bronchiectasis 31.1 TNF MPO IL6 IFNG CRP
14 angular cheilitis 31.1 TNF IL6 IL17A CD4
15 acquired immunodeficiency syndrome 31.0 TNF IL6 IL2 IFNG CRP CD4
16 actinomycosis 31.0 TNF CRP CD4
17 polyclonal hypergammaglobulinemia 31.0 TRIM21 TNFSF13B IL6 CRP CD8A CD4
18 vitiligo-associated multiple autoimmune disease susceptibility 1 31.0 TNF IL2 IL17A CD8A CD4
19 gingivitis 31.0 TNF MPO IL6 IL2 IFNG
20 actinic keratosis 31.0 TNF IL6 CD8A CD4
21 common variable immunodeficiency 30.9 TNFSF13B TNF MPO LRBA IL6 IL2
22 pain agnosia 30.9 TNF IL6 CRP
23 leishmaniasis 30.9 TNF IL6 IL2 IL17A IFNG
24 interstitial lung disease 30.9 TNF IL6 IFNG IFIH1 CRP
25 respiratory failure 30.9 TNF MPO IL6 IL2 IL17A IFNG
26 mixed connective tissue disease 30.9 TNFSF13B TNF IL6 IFNG
27 contact dermatitis 30.8 TNF IL6 IL2 IL17A IFNG CD8A
28 lymphangioma 30.8 TNF IL6 IL17A IFNG CD8A CD4
29 sialadenitis 30.8 TRIM21 TNFSF13B TNF CD4
30 bronchiolitis 30.8 TNF IL6 IL2 IL17A IFNG CRP
31 erythema multiforme 30.8 TNF IL6 IL2 IFNG
32 autoimmune disease 30.8 TRIM21 TNFSF13B TNF PRTN3 IL6 IL2
33 immune deficiency disease 30.8 TNFSF13B TNF IL6 IL2 IL17A IFNG
34 nonspecific interstitial pneumonia 30.7 TRIM21 PRTN3 NLRC4 MPO IFIH1 CRP
35 lymphocytic colitis 30.7 TNF CD8A CD4
36 cellulitis 30.7 TNF IL6 IL17A CRP CD8A CD4
37 funisitis 30.7 TNF IL6 CRP
38 esophageal candidiasis 30.7 IL17A CD8A CD4
39 serum amyloid a amyloidosis 30.7 TNF IL6 CRP
40 dysgammaglobulinemia 30.7 LRBA CD8A CD4
41 dermatophytosis 30.7 TNF IL17A CD4
42 allergic contact dermatitis 30.7 TNF IL6 IL2 IL17A IFNG CD8A
43 acute graft versus host disease 30.7 TNF IL2 IFNG
44 fasciitis 30.7 TNF IL6 IL2 IFNG
45 graft-versus-host disease 30.7 TNF IL2 IFNG
46 interstitial nephritis 30.7 TNF PRTN3 CRP CD8A CD4
47 urticaria 30.7 TNF IL6 IL17A IFNG CRP CD4
48 polyarteritis nodosa 30.7 TNF PRTN3 MPO IL6 CRP
49 juvenile rheumatoid arthritis 30.7 TNF IL6 IL2 CRP CD4
50 stomatitis 30.6 TNF MTOR IL6 IL2 IFNG IFIH1

Comorbidity relations with Lymphoid Interstitial Pneumonia via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia

Graphical network of the top 20 diseases related to Lymphoid Interstitial Pneumonia:



Diseases related to Lymphoid Interstitial Pneumonia
Sources

Symptoms & Phenotypes for Lymphoid Interstitial Pneumonia

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Human phenotypes related to Lymphoid Interstitial Pneumonia:

58 30 (show all 37)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 cough 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0012735
2 failure to thrive 58 30 Frequent (33%) Frequent (79-30%)
 HP:0001508
3 fatigue 58 30 Frequent (33%) Frequent (79-30%)
 HP:0012378
4 dyspnea 58 30 Frequent (33%) Frequent (79-30%)
 HP:0002094
5 eczema 58 30 Frequent (33%) Frequent (79-30%)
 HP:0000964
6 hypoxemia 58 30 Frequent (33%) Frequent (79-30%)
 HP:0012418
7 restrictive ventilatory defect 58 30 Frequent (33%) Frequent (79-30%)
 HP:0002091
8 severe viral infection 58 30 Frequent (33%) Frequent (79-30%)
 HP:0031691
9 crackles 58 30 Frequent (33%) Frequent (79-30%)
 HP:0030830
10 autoimmune antibody positivity 58 30 Frequent (33%) Frequent (79-30%)
 HP:0030057
11 wheezing 58 30 Frequent (33%) Frequent (79-30%)
 HP:0030828
12 clubbing 58 30 Frequent (33%) Frequent (79-30%)
 HP:0001217
13 decreased dlco 58 30 Frequent (33%) Frequent (79-30%)
 HP:0045051
14 parenchymal consolidation 58 30 Frequent (33%) Frequent (79-30%)
 HP:0032177
15 multiple pulmonary cysts 58 30 Frequent (33%) Frequent (79-30%)
 HP:0005948
16 hepatomegaly 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0002240
17 fever 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0001945
18 immunodeficiency 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0002721
19 bronchiectasis 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0002110
20 skin rash 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0000988
21 weight loss 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0001824
22 mediastinal lymphadenopathy 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0100721
23 enlarged kidney 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0000105
24 keratoconjunctivitis sicca 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0001097
25 respiratory tract infection 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0011947
26 raynaud phenomenon 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0030880
27 rheumatoid arthritis 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0001370
28 abnormality of connective tissue 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0003549
29 pulmonary venous hypertension 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0030950
30 centrilobular ground-glass opacification on pulmonary hrct 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0025180
31 subpleural interstitial thickening 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0025178
32 pulmonary fibrosis 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0002206
33 autoimmunity 58 Frequent (79-30%)
34 cor pulmonale 30 HP:0001648
35 aortic valve stenosis 30 HP:0001650
36 ground-glass opacification on pulmonary hrct 58 Frequent (79-30%)
37 lymphocytic interstitial pneumonia 30 HP:0006527

Symptoms via clinical synopsis from OMIM®:

57 (Updated 08-Dec-2022)
Cardiac:
cor pulmonale
aortic stenosis

Limbs:
digital clubbing

Pulmonary:
lymphoid interstitial pneumonia

Clinical features from OMIM®:

247610 (Updated 08-Dec-2022)

UMLS symptoms related to Lymphoid Interstitial Pneumonia:


oral manifestations; cheilodynia

MGI Mouse Phenotypes related to Lymphoid Interstitial Pneumonia:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 CD19 CD4 CRP IFIH1 IFNG IL17A
2 immune system MP:0005387 10.21 CD19 CD4 CD8A CRP IFIH1 IFNG
3 renal/urinary system MP:0005367 10.11 CD19 CD8A IFIH1 IFNG IL17A IL6
4 cellular MP:0005384 10.1 CD19 CD4 CD8A IFIH1 IFNG IL2
5 hematopoietic system MP:0005397 10.09 CD19 CD4 CD8A IFIH1 IFNG IL17A
6 neoplasm MP:0002006 10.04 CD19 IFNG IL2 IL6 TNF TSC2
7 liver/biliary system MP:0005370 10.03 CD19 IFIH1 IFNG IL17A IL2 IL6
8 no phenotypic analysis MP:0003012 10.02 CD4 IFNG IL17A IL2 MTOR PRTN3
9 digestive/alimentary MP:0005381 9.97 CD19 CD4 IFNG IL17A IL2 IL6
10 mortality/aging MP:0010768 9.83 CD19 CD4 CD8A IFIH1 IFNG IL17A
11 integument MP:0010771 9.32 CD19 CD4 CD8A IFIH1 IFNG IL17A
Sources

Drugs & Therapeutics for Lymphoid Interstitial Pneumonia

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Dose-Ranging Study of the Efficacy and Safety of Bardoxolone Methyl in Patients With Pulmonary Hypertension Completed NCT02036970 Phase 2 Bardoxolone methyl;Placebo

Search NIH Clinical Center for Lymphoid Interstitial Pneumonia

Cochrane evidence based reviews: lip diseases

Sources

Genetic Tests for Lymphoid Interstitial Pneumonia

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Anatomical Context for Lymphoid Interstitial Pneumonia

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Organs/tissues related to Lymphoid Interstitial Pneumonia:

FMA: Lip
MalaCards : Lung, Kidney, Skin, Bone Marrow, Salivary Gland, Bone, T Cells
Sources

Publications for Lymphoid Interstitial Pneumonia

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Articles related to Lymphoid Interstitial Pneumonia:

(show top 50) (show all 460)
# Title Authors PMID Year
1
Familial lymphoid interstitial pneumonia: a long-term follow-up. 62 57
7360539 1980
2
High-Resolution Computed Tomography of Cystic Lung Disease. 62
36252611 2022
3
Airspace Enlargement with Fibrosis in a Young Heavy Smoker Mimicking Diffuse Cystic Lung Disease. 62
36422188 2022
4
Severe extra-glandular involvement and pleural effusions complicating primary Sjogren's syndrome: a case report. 62
36253840 2022
5
An outbreak of visna-maedi in a flock of sheep in Southern Brazil. 62
35478313 2022
6
PCV3-associated reproductive failure in pig herds in Brazil. 62
36097231 2022
7
Lymphocytic Interstitial Pneumonia Associated with Sjögren Syndrome: Case-based Review. 62
35980075 2022
8
Pulmonary lymphoproliferative disorders in children: a practical review. 62
35352133 2022
9
Clinical and radiological features of lung disorders related to connective-tissue diseases: a pictorial essay. 62
35767157 2022
10
Sjögren's syndrome as a cause of both lymphoid interstitial pneumonia and light chain deposition disease in a single patient. 62
35750435 2022
11
Opportunistic pneumonia caused by E. cuniculi in mice immunosuppressed with cyclophosphamide. 62
35278762 2022
12
The respiratory manifestations in patients with primary Sjögren's syndrome: is interstitial lung disease related to disease activity? 62
36422505 2022
13
Transformation of lymphoid interstitial pneumonia (LIP) into malignant lymphoma in patients with Sjogren's syndrome: a case report and literature review. 62
35428307 2022
14
Interstitial lung disease in Primary Sjögren's syndrome. 62
35220958 2022
15
Lymphocytic interstitial pneumonia in a patient with lymphocytic colitis. 62
36127942 2022
16
Connective tissue disease-related interstitial lung disease (CTD-ILD) and interstitial lung abnormality (ILA): Evolving concept of CT findings, pathology and management. 62
35445144 2022
17
Systemic lupus erythematosus presenting with lymphoid interstitial pneumonia as an initial manifestation. 62
34969786 2021
18
Lymphocytic interstitial pneumonia as an extremely rare manifestation of systemic lupus erythematosus. 62
34632752 2021
19
A Case of Progressive Dyspnea: Lymphocytic Interstitial Pneumonia in Collagen Vascular Disease. 62
34729259 2021
20
The other connective tissue disease-associated interstitial lung diseases: Sjogren's syndrome, mixed connective tissue disease, and systemic lupus erythematosus. 62
34127620 2021
21
Fibrotic Idiopathic Interstitial Lung Disease: The Molecular and Cellular Key Players. 62
34445658 2021
22
CT findings of pulmonary cysts. 62
33741130 2021
23
The etiology of diffuse cystic lung diseases: an analysis of 1010 consecutive cases in a LAM clinic. 62
34118978 2021
24
Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome Manifesting as Lymphocytic Interstitial Pneumonia and Treatment-Resistant Bullous Pemphigoid. 62
34143686 2021
25
A Case of Pulmonary Adenocarcinoma Presenting with Diffuse Cystic Lesions. 62
34248557 2021
26
Pulmonary Histopathology Findings in Patients With STAT3 Gain of Function Syndrome. 62
33651637 2021
27
[Clinical characteristics and related factors of systemic lupus erythematosus with interstitial pneumonia]. 62
33879896 2021
28
Characteristics of primary Sjögren's syndrome related lymphocytic interstitial pneumonia. 62
32613392 2021
29
Connective tissue disease-related interstitial lung disease (CTD-ILD) and interstitial lung abnormality (ILA): Evolving concept of CT findings, pathology and management. 62
33364263 2021
30
Asymptomatic Lymphocytic Interstitial Pneumonia with Extensive HRCT Changes Preceding Sjogren's Syndrome. 62
33505755 2021
31
Granulomatous-Lymphocytic Interstitial Lung Disease Mimicking Sarcoidosis. 62
34744421 2021
32
Sjogren's Syndrome and Pulmonary Disease. 62
33788195 2021
33
STAT3 gain-of-function mutation in an adult patient. 62
34875609 2021
34
Interstitial Lung Disease in Common Variable Immunodeficiency. 62
33776995 2021
35
Lymphocytic interstitial pneumonia with tiny cysts of peribronchovascular distribution on CT. 62
33363980 2020
36
Characterization of Interstitial Lung Disease Associated With Anti-Ribonucleoprotein Antibodies. 62
31415476 2020
37
Lung disease in patients with common variable immunodeficiency. 62
32446785 2020
38
CT-guided biopsy in the differential diagnosis of Sjogren syndrome associated cystic lung disease: A case of lung nodular AL-k amyloidosis. 62
32994835 2020
39
Idiopathic multicentric Castleman disease with pulmonary and cutaneous lesions treated with tocilizumab: A case report. 62
33195662 2020
40
Chest computed tomography to evaluate lymphocytic interstitial pneumonia. 62
33071382 2020
41
Lymphocytic interstitial pneumonia: computed tomography findings in 36 patients. 62
33071371 2020
42
Ultra-rare cystic disease. 62
32878971 2020
43
Acute severe idiopathic lymphoid interstitial pneumonia: A case report. 62
32791765 2020
44
Interstitial lung disease in Sjögren's syndrome: a clinical review. 62
33095142 2020
45
The interstitial lung disease spectrum under a uniform diagnostic algorithm: a retrospective study of 1,945 individuals. 62
32802448 2020
46
Rituximab effect in severe progressive connective tissue disease-related lung disease: preliminary data. 62
32157369 2020
47
[Chest High-resolution Computed Tomography Imaging Features of Lung Involvement in Rheumatoid Arthritis]. 62
32385026 2020
48
Lymphocytic interstitial pneumonia and follicular bronchiolitis in children: A registry-based case series. 62
32040879 2020
49
Bronchiectasis in common variable immunodeficiency: A systematic review and meta-analysis. 62
31833673 2020
50
EBV-associated lymphoid interstitial pneumonia in IBD patient: Case report and literature review. 62
32373453 2020
Sources

Variations for Lymphoid Interstitial Pneumonia

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Expression for Lymphoid Interstitial Pneumonia

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Search GEO for disease gene expression data for Lymphoid Interstitial Pneumonia.
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Pathways for Lymphoid Interstitial Pneumonia

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Pathways related to Lymphoid Interstitial Pneumonia according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 64
Show member pathways
 13.81 VEGFD TSC2 TNFSF13B TNF MTOR IL6
2
Innate Immune System 66
Show member pathways
 13.8 CD19 CD1A CD4 CD8A CRP IFIH1
3
TGF-Beta Pathway 64
Show member pathways
 13.53 VEGFD TNFSF13B TNF MTOR IL6 IL2
4
Akt Signaling 64
Show member pathways
 13.39 VEGFD TSC2 TNFSF13B TNF MTOR IL6
5
PAK Pathway 64
Show member pathways
 13.29 VEGFD TNFSF13B TNF IL6 IL2 IL17A
6
Cytokine Signaling in Immune system 66
Show member pathways
 13.29 TRIM21 TNFSF13B TNF PRTN3 IL6 IL2
7
p70S6K Signaling 64
Show member pathways
 13.04 CD19 IL2 IL6 MTOR TSC2 VEGFD
8
PI3K-Akt signaling pathway 74
Show member pathways
 12.94 CD19 IL2 IL6 MTOR TSC2 VEGFD
9
NF-KappaB Family Pathway 64
Show member pathways
 12.7 VEGFD TNFSF13B TNF IL6 IL2
10
Overview of interferons-mediated signaling pathway 74
Show member pathways
 12.63 VEGFD TNF MTOR IL6 IL2 IL17A
11
Immune response IL-23 signaling pathway 22
Show member pathways
 12.58 TNF MPO IL6 IL2 IL17A IFNG
12
NF-kappaB Signaling 3
12.54 TNFSF13B TNF MPO IL2 IL17A IFNG
13
T-cell activation SARS-CoV-2 74
Show member pathways
 12.04 TSC2 TNF MTOR IL2 IL17A IFNG
14
Spinal cord injury 74
12.01 TNFSF13B TNF IL6 IL2 IFNG
15
IL12-mediated signaling events 61
Show member pathways
 11.98 CD4 CD8A IFNG IL2 MTOR
16
IL27-mediated signaling events 61
Show member pathways
 11.97 TNF IL6 IL2 IL17A IFNG CD4
17
Allograft rejection 74
11.9 IFNG IL17A IL2 TNF
18
Th17 Differentiation 65
Show member pathways
 11.88 IL6 IL17A IFNG CD4
19
Innate Lymphoid Cells Differentiation 65
11.86 TNF IL2 IL17A IFNG CD8A CD4
20
Network map of SARS-CoV-2 signaling pathway 74
Show member pathways
 11.8 IL6 CRP CD8A CD4
21
C-MYB transcription factor network 61
11.79 PRTN3 MPO CD4
22
Acute viral myocarditis 74
11.78 IL6 IL2 IFNG CD4
23
Glucocorticoid receptor regulatory network 61
11.76 IL6 IL2 IFNG
24
Extrafollicular B cell activation by SARS-CoV-2 74
11.76 CD19 CRP IFNG IL2 IL6 TNF
25
Th17 cell differentiation pathway 74
11.72 MTOR IL6 IL2 IL17A IFNG CD4
26
AP-1 transcription factor network 61
11.71 IL6 IL2 IFNG
27
Regulation of Telomerase 61
11.7 MTOR IL2 IFNG
28
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 61
Show member pathways
 11.7 TNF IL2 IFNG
29
Photodynamic therapy-induced NF-kB survival signaling 74
Show member pathways
 11.68 IFNG IL2 IL6 TNF
30
IL 10 signaling pathway 67
11.66 TNFSF13B TNF IL6
31
Inflammatory bowel disease signaling 74
Show member pathways
 11.64 TNF IL6 IL2 IFNG
32
Hematopoietic Stem Cells and Lineage-specific Markers 65
11.62 TNF MPO IL6 IL2 IFNG CD8A
33
SHP2 signaling 61
11.58 IL6 IL2 IFNG
34
Non-genomic actions of 1,25 dihydroxyvitamin D3 74
11.56 TNF IL6 IFNG
35
THC Differentiation Pathway 64
11.55 TNF IL2 IFNG CD4
36
Th2 Differentiation 65
11.5 IL2 IFNG CD4
37
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.49 TNF IL6 IFNG
38
IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types 65
Show member pathways
 11.39 TNF IL2 IFNG
39
Development and heterogeneity of the ILC family 74
11.33 TNF IL6 IL17A IFNG
40
Cytokines and inflammatory response 74
11.32 TNF IL6 IL2 IFNG CD4
41
Prostaglandin signaling 74
11.26 TNF IL6 IL17A
42
IL12 signaling mediated by STAT4 61
11.24 IL2 IFNG CD4
43
Dendritic Cells Developmental Lineage Pathway 65
11.09 TNF IL6 IL2 IFNG CD8A CD4
44
Overview of nanoparticle effects 74
11.07 TNF IL6 CRP
45
Immune infiltration in pancreatic cancer 74
11.06 VEGFD TNF IL6 IL2 IL17A IFNG
46
G-protein signaling_Rap2B regulation pathway 22
11.03 VEGFD TNFSF13B TNF IL6 IL2 IL17A
47
Selective expression of chemokine receptors during T-cell polarization 74
10.95 IL2 IFNG CD4
48
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 66
10.71 IL2 IFNG
49
COVID-19 adverse outcome pathway 74
10.7 IL6 IL2
50
Cells and molecules involved in local acute inflammatory response 74
Show member pathways
 10.37 TNF IL6
Sources

GO Terms for Lymphoid Interstitial Pneumonia

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Cellular components related to Lymphoid Interstitial Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.93 TNF IL17A CD8A CD4 CD1A CD19
2 extracellular space GO:0005615 9.66 CD1A CRP IFNG IL17A IL2 IL6
3 membrane raft GO:0045121 9.61 TNF PRTN3 CD4 CD1A CD19

Biological processes related to Lymphoid Interstitial Pneumonia according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 10.35 TNF NLRC4 MTOR IL6 IL17A CRP
2 defense response to Gram-positive bacterium GO:0050830 10.18 TNF IL6 IL17A CRP
3 adaptive immune response GO:0002250 10.18 IL2 IL17A IFNG CD8A CD4 CD1A
4 positive regulation of inflammatory response GO:0050729 10.16 TNF NLRC4 IL2 IFNG
5 positive regulation of tumor necrosis factor production GO:0032760 10.15 IFIH1 IFNG IL17A IL6
6 positive regulation of protein phosphorylation GO:0001934 10.14 VEGFD TNF MTOR IL2 CD4
7 positive regulation of chemokine production GO:0032722 10.06 TNF IL6 IFNG
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 10.01 TNF IL6 IL2 IFNG
9 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.97 TNF IL6 IL17A
10 positive regulation of interleukin-6 production GO:0032755 9.96 IFIH1 IFNG IL17A IL6 TNF
11 positive regulation of osteoclast differentiation GO:0045672 9.95 TNF IL17A IFNG
12 positive regulation of interleukin-1 beta production GO:0032731 9.85 TNF NLRC4 IL6 IL17A IFNG
13 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.83 TNF IFNG
14 positive regulation of nitrogen compound metabolic process GO:0051173 9.81 TNF IFNG
15 negative regulation of lipid storage GO:0010888 9.8 TNF IL6 CRP
16 immune response GO:0006955 9.8 TNFSF13B TNF IL6 IL2 IL17A IFNG
17 positive regulation of vitamin D biosynthetic process GO:0060557 9.76 IFNG TNF
18 response to gold nanoparticle GO:1990268 9.73 MPO TNF
19 immune system process GO:0002376 9.28 TNFSF13B NLRC4 IL2 IL17A IFIH1 CD8A

Molecular functions related to Lymphoid Interstitial Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.4 TNFSF13B TNF IL6 IL2 IL17A IFNG
Sources

Sources for Lymphoid Interstitial Pneumonia

About this section
2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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