MCID: LYM067
MIFTS: 43

Lymphoid Leukemia

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Lymphoid Leukemia

MalaCards integrated aliases for Lymphoid Leukemia:

Name: Lymphoid Leukemia 38 29 73

Classifications:



External Ids:

UMLS 73 C0023448

Summaries for Lymphoid Leukemia

MalaCards based summary : Lymphoid Leukemia is related to leukemia and myeloid leukemia. An important gene associated with Lymphoid Leukemia is ETV6 (ETS Variant 6), and among its related pathways/superpathways are Transcriptional misregulation in cancer and CXCR4-mediated signaling events. The drugs Methotrexate and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include b cells, myeloid and t cells, and related phenotypes are cellular and growth/size/body region

Wikipedia : 76 Lymphoid leukemias �?? also called lymphocytic, lymphogenous, or lymphoblastic leukemias �?? are a group... more...

Related Diseases for Lymphoid Leukemia

Diseases related to Lymphoid Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 leukemia 31.2 ETV6 FLT3 JAK2
2 myeloid leukemia 30.2 ETV6 FLT3 JAK2
3 leukemia, acute myeloid 29.6 ETV6 FLT3 JAK2 KMT2A SH3GL1
4 acute leukemia 29.5 ETV6 FLT3 JAK2 KMT2A
5 leukemia, chronic myeloid 29.1 ETV6 FLT3 JAK2 KMT2A
6 leukemia, acute lymphoblastic 29.0 ETV6 FLT3 GNB1 KMT2A NBN
7 myelodysplastic syndrome 29.0 ETV6 FLT3 GNB1 JAK2 KMT2A
8 leukemia, chronic lymphocytic 11.7
9 adult acute lymphocytic leukemia 11.5
10 lymphoma 10.3
11 ring chromosome 21 10.1 ETV6 KMT2A
12 cytogenetically normal acute myeloid leukemia 10.1 FLT3 KMT2A
13 hairy cell leukemia 10.0
14 lymphosarcoma 10.0
15 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.0 ETV6 FLT3 KMT2A
16 myeloid sarcoma 10.0 FLT3 KMT2A
17 leukemia, acute lymphoblastic 3 10.0 ETV6 FLT3 KMT2A
18 precursor t-cell acute lymphoblastic leukemia 10.0 ETV6 FLT3 KMT2A
19 subacute myeloid leukemia 9.9 FLT3 JAK2
20 childhood leukemia 9.9 ETV6 KMT2A
21 neutrophilia, hereditary 9.9 FLT3 JAK2
22 core binding factor acute myeloid leukemia 9.9 FLT3 JAK2
23 thrombocythemia 3 9.9 INSL6 JAK2
24 myeloma, multiple 9.9
25 arthritis 9.9
26 pemphigus 9.9
27 paraneoplastic pemphigus 9.9
28 lymphoblastic leukemia, acute, with lymphomatous features 9.8 INSL6 JAK2
29 chronic myelomonocytic leukemia 9.8 ETV6 FLT3 JAK2
30 budd-chiari syndrome 9.8 INSL6 JAK2
31 autoimmune disease 9.7
32 leukemia, chronic lymphocytic 2 9.7
33 breast cancer 9.7
34 porphyria cutanea tarda 9.7
35 retinoblastoma 9.7
36 ataxia-telangiectasia 9.7
37 myelofibrosis 9.7
38 polycythemia vera 9.7
39 thrombocytopenia-absent radius syndrome 9.7
40 crohn's disease 9.7
41 hematopoietic stem cell transplantation 9.7
42 liver cirrhosis 9.7
43 peripheral t-cell lymphoma 9.7
44 renal tubular acidosis 9.7
45 thrombocytopenia 9.7
46 cryptococcal meningitis 9.7
47 mucositis 9.7
48 lymphocytic leukemia 9.7
49 sarcoma 9.7
50 pulmonary alveolar proteinosis 9.7

Comorbidity relations with Lymphoid Leukemia via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Leukemia, Chronic Lymphocytic

Graphical network of the top 20 diseases related to Lymphoid Leukemia:



Diseases related to Lymphoid Leukemia

Symptoms & Phenotypes for Lymphoid Leukemia

MGI Mouse Phenotypes related to Lymphoid Leukemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.92 ETV6 FLT3 GNB1 INSL6 JAK2 KMT2A
2 growth/size/body region MP:0005378 9.7 ETV6 FLT3 JAK2 KMT2A NBN NCKIPSD
3 embryo MP:0005380 9.65 ETV6 GNB1 JAK2 KMT2A NBN
4 mortality/aging MP:0010768 9.5 ETV6 FLT3 GNB1 JAK2 KMT2A NBN
5 neoplasm MP:0002006 9.02 ETV6 FLT3 JAK2 KMT2A NBN

Drugs & Therapeutics for Lymphoid Leukemia

Drugs for Lymphoid Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 700)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-05-2, 1959-05-2 126941
2
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
3
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 302962-49-8 3062316
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1177-87-3
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
6
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 6006 143
7
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58957-92-9 42890
8
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 20830-81-3 30323
9
Cytarabine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 147-94-4 6253
10
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 57-22-7, 2068-78-2 5978
11
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 65271-80-9 4212
12
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-23-7 5754
13
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-03-3
14
Teniposide Approved Phase 4,Phase 3,Phase 2,Not Applicable 29767-20-2 34698
15
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 130167-69-0
16
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 6055-19-2, 50-18-0 2907
17
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 23214-92-8 31703
18
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 174722-31-7 10201696
19
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
20
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
21
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 135968-09-1
22
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
23
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
24
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 58-61-7 60961
25
Pentostatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53910-25-1 439693 40926
26
Cladribine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 4291-63-8 20279
27
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 33419-42-0 36462
28
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 154-42-7 2723601
29
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 75607-67-9, 21679-14-1 30751
30
Vindesine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 59917-39-4, 53643-48-4 40839
31
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 3778-73-2 3690
32
Chlorambucil Approved Phase 4,Phase 3,Phase 2,Phase 1 305-03-3 2708
33
Vidarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 24356-66-9 32326 21704
34
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
35
Ofatumumab Approved Phase 4,Phase 3,Phase 2,Phase 1 679818-59-8 6918251
36
Thiotepa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52-24-4 5453
37
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 55-98-1 2478
38
Epirubicin Approved Phase 4,Phase 3,Phase 2 56420-45-2 41867
39
Valganciclovir Approved, Investigational Phase 4,Phase 2,Not Applicable 175865-60-8 64147
40
Posaconazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 171228-49-2 147912
41
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 3081921 477468
42
Methylphenidate Approved, Investigational Phase 4,Not Applicable 113-45-1 4158
43
Dopamine Approved Phase 4,Not Applicable 51-61-6, 62-31-7 681
44
Oprelvekin Approved, Investigational Phase 4 145941-26-0
45
Azacitidine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 320-67-2 9444
46
Morphine Approved, Investigational Phase 4,Phase 3,Not Applicable 57-27-2 5288826
47
Decitabine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 2353-33-5 451668
48
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 5280965 14956
49
Nicotine Approved Phase 4 54-11-5 942 89594
50
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-30-3 6037

Interventional clinical trials:

(show top 50) (show all 2862)
# Name Status NCT ID Phase Drugs
1 Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients Unknown status NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
2 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
3 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Unknown status NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
4 Treatment of High Risk Adult Acute Lymphoblastic Leukemia Unknown status NCT00853008 Phase 4 Vincristine;Daunorubicin;Prednisone;Mitoxantrone;Cytosine Arabinoside;Dexamethasone;Methotrexate (MTX);Cytarabine;ASP;Mercaptopurine;Teniposide;Hydrocortisone
5 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
6 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
7 Efficacy and Safety of Nipent, Cytoxan and Rituxan in the Treatment of Chronic Lymphocytic Leukemia. Unknown status NCT00131313 Phase 4 Nipent, Cytoxan, Rituxan
8 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
9 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Unknown status NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
10 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
11 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
12 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
13 Low Grade Lymphoma Unknown status NCT01698866 Phase 4
14 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
15 A Study of MabThera Added to Bendamustine or Chlorambucil in Patients With Chronic Lymphocytic Leukemia (MaBLe) Completed NCT01056510 Phase 4 bendamustine;chlorambucil;rituximab [MabThera/Rituxan]
16 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
17 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
18 LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4 Prednisolone;Daunorubicin;Vincristine;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside
19 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin;Mercaptopurine;Prednisone;Vincristine;Methotrexate
20 LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive Completed NCT00526305 Phase 4 Vincristine;Daunorubicin;Prednisone;L-Asparaginase;Mitoxantrone;Cytosine Arabinoside;Hydrocortisone;Mercaptopurine;Cyclophosphamide;Dexamethasone
21 Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
22 Antiviral Treatment of Chronic Lymphocytic Leukemia Completed NCT01255644 Phase 4 Valganciclovir
23 A Study to Compare Mabthera (Rituximab), Fludarabine and Cyclophosphamide to Mabthera and Chlorambucil in Patients With Chronic Lymphocytic Leukemia and Unfavourable Somatic Status Completed NCT01283386 Phase 4 chlorambucil;cyclophosphamide;fludarabine;rituximab [MabThera]
24 ALL-REZ BFM 2002: Multi-Center Study for Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
25 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
26 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
27 Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
28 Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Completed NCT01200355 Phase 4 micafungin;posaconazole
29 A Study to Confirm the Efficacy and Safety of Fludarabine Phosphate Administered in Untreated Chronic Lymphocytic Leukemia Patients With Anemia and/or Thrombocytopenia Completed NCT00220311 Phase 4 Fludarabine Phosphate (Fludara)
30 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4 Methylphenidate
31 Efficacy and Safety of Ofatumumab Retreatment and Maintenance Treatment in Patients With B-cell Chronic Lymphocytic Leukemia (CLL) Completed NCT00802737 Phase 4 Ofatumumab
32 LAL-BR/2001: Study Treatment to Low Risk ALL Completed NCT00526175 Phase 4 Prednisone;Vincristine;Daunorubicin;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside;Mercaptopurine;VP-16
33 The Study on the Pharmacokinetics of PEG-rhG-CSF in Children and Adolescents Completed NCT02953730 Phase 4 PEG-rhG-CSF
34 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4 rhIL-11
35 The Duration of Humoral Immunity and the Memory Cell Function After Vaccination With 7-valent Pneumococcal Conjugate Vaccine in CLL Completed NCT00919321 Phase 4
36 Effect of Epoetin Alfa on Hemoglobin, Symptom Distress, and Quality of Life in Patients Receiving Chemotherapy Completed NCT00524407 Phase 4 Epoetin alfa
37 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
38 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4 Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
39 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
40 Nilotinib in Newly Diagnosed Adult Philadelphia Chromosome & /or BCR-ABL Positive Chronic Myeloid Leukaemia in Chronic Phase Completed NCT01061177 Phase 4 Nilotinib
41 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
42 Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years) Recruiting NCT01366898 Phase 4 Dexamethasona, Idarubicine, ARA-C, Methotrexate
43 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
44 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid Recruiting NCT01906671 Phase 4 Xaluprine;Puri-Nethol
45 PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years Recruiting NCT01358201 Phase 4 vINCRISTINE;Dexamethasone;Methotrexate;Cytosine arabinoside
46 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
47 Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Recruiting NCT02036489 Phase 4 Vincristine;Daunorubicin;Prednisone;L-asparaginase;Ciclophosphamide;Metotrexate;ARA-C;Hidrocortisone;Mercaptopurine;VP-16;Dexametasone
48 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4 Anti-human Thymoglobulin;Placebo
49 G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor Recruiting NCT02933333 Phase 4
50 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate

Search NIH Clinical Center for Lymphoid Leukemia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Lymphoid Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Lymphoid Leukemia:
StemEx�, umbilical cord blood stem/progenitor cells for hematological diseases
Embryonic/Adult Cultured Cells Related to Lymphoid Leukemia:
Umbilical cord blood stem/progenitor cells (Stemex) PMIDs: 18209724

Genetic Tests for Lymphoid Leukemia

Genetic tests related to Lymphoid Leukemia:

# Genetic test Affiliating Genes
1 Lymphoid Leukemia 29

Anatomical Context for Lymphoid Leukemia

MalaCards organs/tissues related to Lymphoid Leukemia:

41
B Cells, Myeloid, T Cells, Bone, Bone Marrow, Skin, Liver

Publications for Lymphoid Leukemia

Articles related to Lymphoid Leukemia:

(show top 50) (show all 393)
# Title Authors Year
1
Proteomic Profile of Lymphoid Leukemia. ( 29394974 )
2018
2
KML001 and doxercalciferol induce synergistic antileukemic effect in acute lymphoid leukemia cells. ( 28586017 )
2017
3
Epigenetic drug combination overcomes osteoblast-induced chemoprotection in pediatric acute lymphoid leukemia. ( 28171800 )
2017
4
Peripheral T-Cell Lymphoma in Mediastinum Lymph Nodes and Lung Associated to Histoplasmosis in a Patient with Chronic Lymphoid Leukemia/Small Lymphocytic Lymphoma. ( 28698787 )
2017
5
DNA damage response in patients with pediatric Acute Lymphoid Leukemia during induction therapy. ( 28109975 )
2017
6
Lipoxygenase Inhibitors Nordihydroguaiaretic Acid and Fungus Lecanicillum lecanii Extract Induce Death of Lymphoid Leukemia Cells. ( 28744653 )
2017
7
Incidence of Myelofibrosis in Chronic Myeloid Leukemia, Multiple Myeloma, and Chronic Lymphoid Leukemia during Various Phases of Diseases. ( 28239786 )
2017
8
Time and spatial trends in lymphoid leukemia and lymphoma incidence and survival among children and adolescents in Manitoba, Canada: 1984-2013. ( 28430788 )
2017
9
Inverse Correlation of Lymphoid Leukemia Incidence and Anemia Prevalence among Preschool Children. ( 28464174 )
2017
10
Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function. ( 26801976 )
2016
11
Leukemia-free survival in myeloid leukemia, but not in lymphoid leukemia, is predicted by early CD4+ reconstitution following unrelated cord blood transplantation in children: a multicenter retrospective cohort analysis. ( 27159172 )
2016
12
Invasive fungal diseases in patients with acute lymphoid leukemia. ( 26949001 )
2016
13
Advanced chronic lymphoid leukemia with severe bronchopneumonia: an Autopsy Case Report. ( 27284536 )
2016
14
Extramedullary Relapse of Acute Myeloid and Lymphoid Leukemia in Children: A Retrospective Analysis. ( 27617062 )
2016
15
Type distribution of lymphoid leukemia from Cancer Incidence in Five Continents Vol. X. ( 26941374 )
2016
16
Non-biased and complete case registration of lymphoid leukemia and lymphoma for five years: a first representative index of Japan from an epidemiologically stable Miyagi Prefecture. ( 27185073 )
2016
17
Chimeric Antigen Receptor-Modified T Cells in Chronic Lymphoid Leukemia; Chimeric Antigen Receptor-Modified T Cells for Acute Lymphoid Leukemia; Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia. ( 26962747 )
2016
18
E2A-PBX1 Remodels Oncogenic Signaling Networks in B-cell Precursor Acute Lymphoid Leukemia. ( 27758892 )
2016
19
Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome-Positive Lymphoid Leukemia. ( 26637365 )
2016
20
Correction: Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function. ( 27197270 )
2016
21
Synthesis and evaluation of the cytotoxic activity of novel ethyl 4-[4-(4-substitutedpiperidin-1-yl)]benzyl-phenylpyrrolo[1,2-a]quinoxaline-carboxylate derivatives in myeloid and lymphoid leukemia cell lines. ( 26945110 )
2016
22
Clonal conversion of B lymphoid leukemia reveals cross-lineage transfer of malignant states. ( 27913602 )
2016
23
[Association between polymorphism of RAD50 gene and acute lymphoid leukemia in children]. ( 26014697 )
2015
24
T-cell acute lymphoid leukemia resembling Burkitt leukemia cell morphology: A case report. ( 25663889 )
2015
25
ZAP-70 protein expression in B-cell chronic lymphoid leukemia: a single center experience from Pakistan. ( 25743836 )
2015
26
Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemia. ( 25990863 )
2015
27
Acute oral complications in a pediatric patient with acute lymphoid leukemia. ( 26711327 )
2015
28
Serum 25-hydroxyvitamin D Insufficiency in B-Chronic Lymphoid Leukemia at the Time of Disease Presentation in Pakistan. ( 26320484 )
2015
29
Blinatumomab: a bispecific T cell engager (BiTE) antibody against CD19/CD3 for refractory acute lymphoid leukemia. ( 26337639 )
2015
30
Growth Inhibition Accompanied by MOB1 Upregulation in Human Acute Lymphoid Leukemia Cells by 3-Deazaneplanocin A. ( 26298709 )
2015
31
Associations between genetic variants in folate and drug metabolizing pathways and relapse risk in pediatric acute lymphoid leukemia on CCG-1952. ( 26605150 )
2015
32
Chemotherapy Exposure and outcomes Among Patients Diagnosed with Chronic Lymphoid Leukemia. ( 26532698 )
2015
33
Neutralization of (NK-cell-derived) B-cell activating factor by Belimumab restores sensitivity of chronic lymphoid leukemia cells to direct and Rituximab-induced NK lysis. ( 25710310 )
2015
34
Phase II Trial of Reduced-Intensity Busulfan/Clofarabine Conditioning with Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Acute Myeloid Leukemia, Myelodysplastic Syndromes, and Acute Lymphoid Leukemia. ( 26260679 )
2015
35
Clinico-hematological profile of patients with B-chronic lymphoid leukemia in Pakistan. ( 25684527 )
2015
36
Role of Interleukin-10 Gene Promoter Region Polymorphism in the Development of Chronic Lymphoid Leukemia. ( 26642793 )
2015
37
Direct Coombs Test Positivity in B-Chronic Lymphoid Leukemia: a Marker of Advanced Clinical Disease. ( 26320488 )
2015
38
Complete remission after single agent blinatumomab in a patient with pre-B acute lymphoid leukemia relapsed and refractory to three prior regimens: hyperCVAD, high dose cytarabine mitoxantrone and CLAG. ( 27468365 )
2015
39
Clofarabine for the treatment of Adult Acute Lymphoid Leukemia A review article by the GRAALL intergroup. ( 24996442 )
2014
40
Changes in the treatment landscape for chronic lymphoid leukemia. ( 25014693 )
2014
41
Endothelial Health in Childhood Acute Lymphoid Leukemia Survivors: Pilot Evaluation With Peripheral Artery Tonometry. ( 24577544 )
2014
42
A Pilot Study for the Detection of FLT3-ITD Mutation Frequency in 25 Iraqi Patients With Acute Lymphoid Leukemia in 2 Iraqi Hospitals. ( 24390456 )
2014
43
Correlation between FDG/PET, histology, characteristics, and survival in 332 patients with chronic lymphoid leukemia. ( 24615780 )
2014
44
Normalization of lymphocyte count after high ablative dose of I-131 in a patient with chronic lymphoid leukemia and secondary papillary carcinoma of the thyroid. Case report. ( 24728254 )
2014
45
Viability and stress protection of chronic lymphoid leukemia cells involves overactivation of mitochondrial phosphoSTAT3Ser727. ( 25299776 )
2014
46
Synthesis and evaluation of the cytotoxic activity of 1,2-furanonaphthoquinones tethered to 1,2,3-1H-triazoles in myeloid and lymphoid leukemia cell lines. ( 25064348 )
2014
47
Identification of GPM6A and GPM6B as potential new human lymphoid leukemia-associated oncogenes. ( 24916915 )
2014
48
Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia. ( 24881631 )
2014
49
Acute lymphoid leukemia cells with greater stem cell antigen-1 (Ly6a/Sca-1) expression exhibit higher levels of metalloproteinase activity and are more aggressive in vivo. ( 24586463 )
2014
50
Evaluation of selected honey and one of its phenolic constituent eugenol against L1210 lymphoid leukemia. ( 25506620 )
2014

Variations for Lymphoid Leukemia

Expression for Lymphoid Leukemia

Search GEO for disease gene expression data for Lymphoid Leukemia.

Pathways for Lymphoid Leukemia

Pathways related to Lymphoid Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 ETV6 FLT3 KMT2A
2 11.14 GNB1 JAK2
3 10.99 GNB1 JAK2
4 9.97 ETV6 FLT3

GO Terms for Lymphoid Leukemia

Cellular components related to Lymphoid Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.23 ETV6 FLT3 GNB1 JAK2 KMT2A NBN

Biological processes related to Lymphoid Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 8.96 FLT3 JAK2
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 8.62 FLT3 JAK2

Molecular functions related to Lymphoid Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTPase binding GO:0051020 8.96 GNB1 SH3GL1
2 type 1 angiotensin receptor binding GO:0031702 8.62 GNB1 JAK2

Sources for Lymphoid Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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