MCID: LYM067
MIFTS: 44

Lymphoid Leukemia

Categories: Immune diseases, Cancer diseases

Aliases & Classifications for Lymphoid Leukemia

MalaCards integrated aliases for Lymphoid Leukemia:

Name: Lymphoid Leukemia 38 29 73

Classifications:



Summaries for Lymphoid Leukemia

MalaCards based summary : Lymphoid Leukemia is related to lymphoblastic leukemia and leukemia. An important gene associated with Lymphoid Leukemia is ETV6 (ETS Variant 6), and among its related pathways/superpathways are Transcriptional misregulation in cancer and CXCR4-mediated signaling events. The drugs Dasatinib and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related phenotypes are cellular and growth/size/body region

Wikipedia : 76 Lymphoid leukemias — also called lymphocytic, lymphogenous, or lymphoblastic leukemias — are a group of... more...

Related Diseases for Lymphoid Leukemia

Diseases related to Lymphoid Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 lymphoblastic leukemia 30.7 ETV6 FLT3 JAK2 NBN
2 leukemia 29.7 ETV6 FLT3 JAK2
3 myeloid leukemia 29.4 ETV6 FLT3 JAK2
4 acute leukemia 28.9 ETV6 FLT3 JAK2 KMT2A
5 leukemia, acute myeloid 28.1 ETV6 FLT3 JAK2 KMT2A SH3GL1
6 myelodysplastic syndrome 27.6 ETV6 FLT3 GNB1 JAK2 KMT2A
7 leukemia, chronic lymphocytic 11.2
8 adult acute lymphocytic leukemia 11.0
9 ring chromosome 21 10.4 ETV6 KMT2A
10 cytogenetically normal acute myeloid leukemia 10.3 FLT3 KMT2A
11 myeloid sarcoma 10.1 FLT3 KMT2A
12 neutrophilia, hereditary 10.1 FLT3 JAK2
13 mn1 10.1 ETV6 FLT3 KMT2A
14 core binding factor acute myeloid leukemia 10.1 FLT3 JAK2
15 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.0 ETV6 FLT3 KMT2A
16 leukemia, acute lymphoblastic 3 10.0 ETV6 FLT3 KMT2A
17 childhood leukemia 10.0 ETV6 KMT2A
18 lymphoma 9.9
19 precursor t-cell acute lymphoblastic leukemia 9.9 ETV6 FLT3 KMT2A
20 chronic myelomonocytic leukemia 9.9 ETV6 FLT3 JAK2
21 bone marrow cancer 9.8 ETV6 FLT3 JAK2
22 hairy cell leukemia 9.7
23 lymphosarcoma 9.7
24 pemphigus 9.7
25 paraneoplastic pemphigus 9.7
26 thrombocythemia 3 9.6 INSL6 JAK2
27 porphyria cutanea tarda 9.6
28 retinoblastoma 9.6
29 myelofibrosis 9.6
30 myeloma, multiple 9.6
31 arthritis 9.6
32 hematopoietic stem cell transplantation 9.6
33 liver cirrhosis 9.6
34 peripheral t-cell lymphoma 9.6
35 renal tubular acidosis 9.6
36 mucositis 9.6
37 pulmonary alveolar proteinosis 9.6
38 bronchopneumonia 9.6
39 porphyria 9.6
40 panniculitis 9.6
41 histoplasmosis 9.6
42 papillary carcinoma 9.6
43 endophthalmitis 9.6
44 t-cell leukemia 9.6
45 thyroiditis 9.6
46 vasculitis 9.6
47 hodgkin's granuloma 9.6
48 acute leukemia of ambiguous lineage 9.6
49 bone marrow necrosis 9.6
50 angiomatosis 9.6

Comorbidity relations with Lymphoid Leukemia via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Leukemia, Chronic Lymphocytic

Graphical network of the top 20 diseases related to Lymphoid Leukemia:



Diseases related to Lymphoid Leukemia

Symptoms & Phenotypes for Lymphoid Leukemia

MGI Mouse Phenotypes related to Lymphoid Leukemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.92 FLT3 GNB1 INSL6 JAK2 KMT2A NBN
2 growth/size/body region MP:0005378 9.7 FLT3 JAK2 KMT2A NBN NCKIPSD SH3GL1
3 embryo MP:0005380 9.65 ETV6 GNB1 JAK2 KMT2A NBN
4 mortality/aging MP:0010768 9.5 ETV6 FLT3 GNB1 JAK2 KMT2A NBN
5 neoplasm MP:0002006 9.02 FLT3 JAK2 KMT2A NBN ETV6

Drugs & Therapeutics for Lymphoid Leukemia

Drugs for Lymphoid Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 690)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 302962-49-8 3062316
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
3
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1959-05-2, 59-05-2 126941
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
5
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 147-94-4 6253
6
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 20830-81-3 30323
7
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58957-92-9 42890
8
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2068-78-2, 57-22-7 5978
9
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
10
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 23214-92-8 31703
11
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 130167-69-0
12
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 135968-09-1
13
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
14
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
15
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 174722-31-7 10201696
16
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 58-61-7 60961
17
Pentostatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53910-25-1 40926 439693
18
Cladribine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 4291-63-8 20279
19
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 33419-42-0 36462
20
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 21679-14-1, 75607-67-9 30751
21
Teniposide Approved Phase 4,Phase 3,Phase 2,Not Applicable 29767-20-2 34698
22
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 154-42-7 2723601
23
Vindesine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 59917-39-4, 53643-48-4 40839
24
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 3778-73-2 3690
25
Chlorambucil Approved Phase 4,Phase 3,Phase 2,Phase 1 305-03-3 2708
26
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-23-7 5754
27
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 65271-80-9 4212
28
Vidarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 24356-66-9 32326 21704
29
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
30
Thiotepa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52-24-4 5453
31
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 55-98-1 2478
32
Valganciclovir Approved, Investigational Phase 4,Phase 2,Not Applicable 175865-60-8 64147
33
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 3081921 477468
34
Posaconazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 171228-49-2 147912
35
Dopamine Approved Phase 4,Not Applicable 51-61-6, 62-31-7 681
36
Methylphenidate Approved, Investigational Phase 4,Not Applicable 113-45-1 4158
37
Oprelvekin Approved, Investigational Phase 4 145941-26-0
38
Menthol Approved Phase 4,Not Applicable 2216-51-5 16666
39
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 14956 5280965
40
Nicotine Approved Phase 4 54-11-5 942 89594
41
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-30-3 6037
42
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 143 6006
43
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 1406-16-2
44
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 3,Early Phase 1,Not Applicable 67-97-0 6221 5280795
45
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 50-14-6 5280793
46
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 31703
47
Butyric Acid Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 107-92-6 264
48
Treosulfan Investigational Phase 4,Phase 3,Phase 2,Phase 1 299-75-2 9296
49
Lactitol Investigational Phase 4,Phase 2,Phase 1 585-86-4 3871
50 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 2759)
# Name Status NCT ID Phase Drugs
1 Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients Unknown status NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
2 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
3 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
4 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
5 Efficacy and Safety of Nipent, Cytoxan and Rituxan in the Treatment of Chronic Lymphocytic Leukemia. Unknown status NCT00131313 Phase 4 Nipent, Cytoxan, Rituxan
6 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
7 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
8 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
9 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
10 Low Grade Lymphoma Unknown status NCT01698866 Phase 4
11 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
12 A Study of MabThera Added to Bendamustine or Chlorambucil in Patients With Chronic Lymphocytic Leukemia (MaBLe) Completed NCT01056510 Phase 4 bendamustine;chlorambucil;rituximab [MabThera/Rituxan]
13 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
14 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
15 LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4 Prednisolone;Daunorubicin;Vincristine;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside
16 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin;Mercaptopurine;Prednisone;Vincristine;Methotrexate
17 LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive Completed NCT00526305 Phase 4 Vincristine;Daunorubicin;Prednisone;L-Asparaginase;Mitoxantrone;Cytosine Arabinoside;Hydrocortisone;Mercaptopurine;Cyclophosphamide;Dexamethasone
18 Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
19 Antiviral Treatment of Chronic Lymphocytic Leukemia Completed NCT01255644 Phase 4 Valganciclovir
20 A Study to Compare Mabthera (Rituximab), Fludarabine and Cyclophosphamide to Mabthera and Chlorambucil in Patients With Chronic Lymphocytic Leukemia and Unfavourable Somatic Status Completed NCT01283386 Phase 4 chlorambucil;cyclophosphamide;fludarabine;rituximab [MabThera]
21 ALL-REZ BFM 2002: Multi-Center Study for Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
22 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
23 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
24 Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
25 Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Completed NCT01200355 Phase 4 micafungin;posaconazole
26 A Study to Confirm the Efficacy and Safety of Fludarabine Phosphate Administered in Untreated Chronic Lymphocytic Leukemia Patients With Anemia and/or Thrombocytopenia Completed NCT00220311 Phase 4 Fludarabine Phosphate (Fludara)
27 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4 Methylphenidate
28 Efficacy and Safety of Ofatumumab Retreatment and Maintenance Treatment in Patients With B-cell Chronic Lymphocytic Leukemia (CLL) Completed NCT00802737 Phase 4 Ofatumumab
29 LAL-BR/2001: Study Treatment to Low Risk ALL Completed NCT00526175 Phase 4 Prednisone;Vincristine;Daunorubicin;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside;Mercaptopurine;VP-16
30 The Study on the Pharmacokinetics of PEG-rhG-CSF in Children and Adolescents Completed NCT02953730 Phase 4 PEG-rhG-CSF
31 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4 rhIL-11
32 The Duration of Humoral Immunity and the Memory Cell Function After Vaccination With 7-valent Pneumococcal Conjugate Vaccine in CLL Completed NCT00919321 Phase 4
33 Effect of Epoetin Alfa on Hemoglobin, Symptom Distress, and Quality of Life in Patients Receiving Chemotherapy Completed NCT00524407 Phase 4 Epoetin alfa
34 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
35 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4 Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
36 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
37 Nilotinib in Newly Diagnosed Adult Philadelphia Chromosome & /or BCR-ABL Positive Chronic Myeloid Leukaemia in Chronic Phase Completed NCT01061177 Phase 4 Nilotinib
38 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
39 Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years) Recruiting NCT01366898 Phase 4 Dexamethasona, Idarubicine, ARA-C, Methotrexate
40 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Recruiting NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
41 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Recruiting NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
42 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
43 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid Recruiting NCT01906671 Phase 4 Xaluprine;Puri-Nethol
44 PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years Recruiting NCT01358201 Phase 4 vINCRISTINE;Dexamethasone;Methotrexate;Cytosine arabinoside
45 Vaccinating Children After Chemotherapy Recruiting NCT02447718 Phase 4
46 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
47 Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Recruiting NCT02036489 Phase 4 Vincristine;Daunorubicin;Prednisone;L-asparaginase;Ciclophosphamide;Metotrexate;ARA-C;Hidrocortisone;Mercaptopurine;VP-16;Dexametasone
48 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4 Anti-human Thymoglobulin;Placebo
49 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate
50 A Clinical Trial of Decitabine in Relapse and Refractory T-lymphoblastic Lymphoma Recruiting NCT03558412 Phase 4 Decitabine

Search NIH Clinical Center for Lymphoid Leukemia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Lymphoid Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Lymphoid Leukemia:
StemEx
Embryonic/Adult Cultured Cells Related to Lymphoid Leukemia:
Umbilical cord blood stem/progenitor cells (Stemex) PMIDs: 18209724

Genetic Tests for Lymphoid Leukemia

Genetic tests related to Lymphoid Leukemia:

# Genetic test Affiliating Genes
1 Lymphoid Leukemia 29

Anatomical Context for Lymphoid Leukemia

MalaCards organs/tissues related to Lymphoid Leukemia:

41
B Cells, T Cells, Bone, Bone Marrow, Myeloid, Kidney, Nk Cells

Publications for Lymphoid Leukemia

Articles related to Lymphoid Leukemia:

(show top 50) (show all 145)
# Title Authors Year
1
Proteomic Profile of Lymphoid Leukemia. ( 29394974 )
2018
2
KML001 and doxercalciferol induce synergistic antileukemic effect in acute lymphoid leukemia cells. ( 28586017 )
2017
3
Epigenetic drug combination overcomes osteoblast-induced chemoprotection in pediatric acute lymphoid leukemia. ( 28171800 )
2017
4
Peripheral T-Cell Lymphoma in Mediastinum Lymph Nodes and Lung Associated to Histoplasmosis in a Patient with Chronic Lymphoid Leukemia/Small Lymphocytic Lymphoma. ( 28698787 )
2017
5
DNA damage response in patients with pediatric Acute Lymphoid Leukemia during induction therapy. ( 28109975 )
2017
6
Lipoxygenase Inhibitors Nordihydroguaiaretic Acid and Fungus Lecanicillum lecanii Extract Induce Death of Lymphoid Leukemia Cells. ( 28744653 )
2017
7
Incidence of Myelofibrosis in Chronic Myeloid Leukemia, Multiple Myeloma, and Chronic Lymphoid Leukemia during Various Phases of Diseases. ( 28239786 )
2017
8
Inverse Correlation of Lymphoid Leukemia Incidence and Anemia Prevalence among Preschool Children. ( 28464174 )
2017
9
Time and spatial trends in lymphoid leukemia and lymphoma incidence and survival among children and adolescents in Manitoba, Canada: 1984-2013. ( 28430788 )
2017
10
Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function. ( 26801976 )
2016
11
Leukemia-free survival in myeloid leukemia, but not in lymphoid leukemia, is predicted by early CD4+ reconstitution following unrelated cord blood transplantation in children: a multicenter retrospective cohort analysis. ( 27159172 )
2016
12
Invasive fungal diseases in patients with acute lymphoid leukemia. ( 26949001 )
2016
13
Advanced chronic lymphoid leukemia with severe bronchopneumonia: an Autopsy Case Report. ( 27284536 )
2016
14
Extramedullary Relapse of Acute Myeloid and Lymphoid Leukemia in Children: A Retrospective Analysis. ( 27617062 )
2016
15
Type distribution of lymphoid leukemia from Cancer Incidence in Five Continents Vol. X. ( 26941374 )
2016
16
Non-biased and complete case registration of lymphoid leukemia and lymphoma for five years: a first representative index of Japan from an epidemiologically stable Miyagi Prefecture. ( 27185073 )
2016
17
Chimeric Antigen Receptor-Modified T Cells in Chronic Lymphoid Leukemia; Chimeric Antigen Receptor-Modified T Cells for Acute Lymphoid Leukemia; Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia. ( 26962747 )
2016
18
E2A-PBX1 Remodels Oncogenic Signaling Networks in B-cell Precursor Acute Lymphoid Leukemia. ( 27758892 )
2016
19
Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome-Positive Lymphoid Leukemia. ( 26637365 )
2016
20
Correction: Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function. ( 27197270 )
2016
21
Synthesis and evaluation of the cytotoxic activity of novel ethyl 4-[4-(4-substitutedpiperidin-1-yl)]benzyl-phenylpyrrolo[1,2-a]quinoxaline-carboxylate derivatives in myeloid and lymphoid leukemia cell lines. ( 26945110 )
2016
22
Clonal conversion of B lymphoid leukemia reveals cross-lineage transfer of malignant states. ( 27913602 )
2016
23
[Association between polymorphism of RAD50 gene and acute lymphoid leukemia in children]. ( 26014697 )
2015
24
T-cell acute lymphoid leukemia resembling Burkitt leukemia cell morphology: A case report. ( 25663889 )
2015
25
ZAP-70 protein expression in B-cell chronic lymphoid leukemia: a single center experience from Pakistan. ( 25743836 )
2015
26
Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemia. ( 25990863 )
2015
27
Acute oral complications in a pediatric patient with acute lymphoid leukemia. ( 26711327 )
2015
28
Panniculitis in Patients Undergoing Treatment With the Bruton Tyrosine Kinase Inhibitor Ibrutinib for Lymphoid Leukemias. ( 26182170 )
2015
29
Serum 25-hydroxyvitamin D Insufficiency in B-Chronic Lymphoid Leukemia at the Time of Disease Presentation in Pakistan. ( 26320484 )
2015
30
Blinatumomab: a bispecific T cell engager (BiTE) antibody against CD19/CD3 for refractory acute lymphoid leukemia. ( 26337639 )
2015
31
Growth Inhibition Accompanied by MOB1 Upregulation in Human Acute Lymphoid Leukemia Cells by 3-Deazaneplanocin A. ( 26298709 )
2015
32
Associations between genetic variants in folate and drug metabolizing pathways and relapse risk in pediatric acute lymphoid leukemia on CCG-1952. ( 26605150 )
2015
33
Chemotherapy Exposure and outcomes Among Patients Diagnosed with Chronic Lymphoid Leukemia. ( 26532698 )
2015
34
Neutralization of (NK-cell-derived) B-cell activating factor by Belimumab restores sensitivity of chronic lymphoid leukemia cells to direct and Rituximab-induced NK lysis. ( 25710310 )
2015
35
Phase II Trial of Reduced-Intensity Busulfan/Clofarabine Conditioning with Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Acute Myeloid Leukemia, Myelodysplastic Syndromes, and Acute Lymphoid Leukemia. ( 26260679 )
2015
36
Clinico-hematological profile of patients with B-chronic lymphoid leukemia in Pakistan. ( 25684527 )
2015
37
Role of Interleukin-10 Gene Promoter Region Polymorphism in the Development of Chronic Lymphoid Leukemia. ( 26642793 )
2015
38
Direct Coombs Test Positivity in B-Chronic Lymphoid Leukemia: a Marker of Advanced Clinical Disease. ( 26320488 )
2015
39
Clofarabine for the treatment of Adult Acute Lymphoid Leukemia A review article by the GRAALL intergroup. ( 24996442 )
2014
40
Changes in the treatment landscape for chronic lymphoid leukemia. ( 25014693 )
2014
41
Endothelial Health in Childhood Acute Lymphoid Leukemia Survivors: Pilot Evaluation With Peripheral Artery Tonometry. ( 24577544 )
2014
42
A Pilot Study for the Detection of FLT3-ITD Mutation Frequency in 25 Iraqi Patients With Acute Lymphoid Leukemia in 2 Iraqi Hospitals. ( 24390456 )
2014
43
Correlation between FDG/PET, histology, characteristics, and survival in 332 patients with chronic lymphoid leukemia. ( 24615780 )
2014
44
Normalization of lymphocyte count after high ablative dose of I-131 in a patient with chronic lymphoid leukemia and secondary papillary carcinoma of the thyroid. Case report. ( 24728254 )
2014
45
Viability and stress protection of chronic lymphoid leukemia cells involves overactivation of mitochondrial phosphoSTAT3Ser727. ( 25299776 )
2014
46
Synthesis and evaluation of the cytotoxic activity of 1,2-furanonaphthoquinones tethered to 1,2,3-1H-triazoles in myeloid and lymphoid leukemia cell lines. ( 25064348 )
2014
47
Identification of GPM6A and GPM6B as potential new human lymphoid leukemia-associated oncogenes. ( 24916915 )
2014
48
Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia. ( 24881631 )
2014
49
Acute lymphoid leukemia cells with greater stem cell antigen-1 (Ly6a/Sca-1) expression exhibit higher levels of metalloproteinase activity and are more aggressive in vivo. ( 24586463 )
2014
50
Evaluation of selected honey and one of its phenolic constituent eugenol against L1210 lymphoid leukemia. ( 25506620 )
2014

Variations for Lymphoid Leukemia

Expression for Lymphoid Leukemia

Search GEO for disease gene expression data for Lymphoid Leukemia.

Pathways for Lymphoid Leukemia

Pathways related to Lymphoid Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 ETV6 FLT3 KMT2A
2 11.14 GNB1 JAK2
3 10.99 GNB1 JAK2
4 9.97 ETV6 FLT3

GO Terms for Lymphoid Leukemia

Cellular components related to Lymphoid Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.23 ETV6 FLT3 GNB1 JAK2 KMT2A NBN

Biological processes related to Lymphoid Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of kinase activity GO:0033674 9.16 FLT3 NBN
2 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 8.96 FLT3 JAK2
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 8.62 FLT3 JAK2

Molecular functions related to Lymphoid Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTPase binding GO:0051020 8.96 GNB1 SH3GL1
2 type 1 angiotensin receptor binding GO:0031702 8.62 GNB1 JAK2

Sources for Lymphoid Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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