Lymphoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LYM118 MIFTS: 68	Lymphoma Categories: Blood diseases, Cancer diseases, Immune diseases, Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Lymphoma

MalaCards integrated aliases for Lymphoma:

Name: Lymphoma ¹² ⁷⁴ ⁵⁸ ²⁹ ⁵⁴ ⁶ ⁴² ⁴³ ¹⁵ ¹⁷ ⁷¹

Lymphoid Neoplasm ⁷¹

Lymphoid Cancers ⁷¹

Lymphoid Cancer ¹²

Lymphomas ¹⁵

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Blood diseases Immune diseases Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Neoplasms

Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue

Other and unspecified types of non-Hodgkin lymphoma

Non-Hodgkin lymphoma, unspecified

Orphanet: ⁵⁸

Rare haematological diseases

External Ids:

Disease Ontology ¹² DOID:0060058

MeSH ⁴³ D008223

NCIt ⁴⁹ C3208 C7065

SNOMED-CT ⁶⁷ 118600007 414628006

ICD10 ³² C85.9

MESH via Orphanet ⁴⁴ D008223

UMLS via Orphanet ⁷² C0024299

Orphanet ⁵⁸ ORPHA223735

EFO ¹⁷ EFO_0000574

UMLS ⁷¹ C0024299 C0598798 C0746336

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Summaries for Lymphoma

MedlinePlus : ⁴² Lymphoma is a cancer of a part of the immune system called the lymph system. There are many types of lymphoma. One type is Hodgkin disease. The rest are called non-Hodgkin lymphomas. Non-Hodgkin lymphomas begin when a type of white blood cell, called a T cell or B cell, becomes abnormal. The cell divides again and again, making more and more abnormal cells. These abnormal cells can spread to almost any other part of the body. Most of the time, doctors don't know why a person gets non-Hodgkin lymphoma. You are at increased risk if you have a weakened immune system or have certain types of infections. Non-Hodgkin lymphoma can cause many symptoms, such as Swollen, painless lymph nodes in the neck, armpits or groin Unexplained weight loss Fever Soaking night sweats Coughing, trouble breathing or chest pain Weakness and tiredness that don't go away Pain, swelling or a feeling of fullness in the abdomen Your doctor will diagnose lymphoma with a physical exam, blood tests, a chest x-ray, and a biopsy. Treatments include chemotherapy, radiation therapy, targeted therapy, biological therapy, or therapy to remove proteins from the blood. Targeted therapy uses drugs or other substances that attack specific cancer cells with less harm to normal cells. Biologic therapy boosts your body's own ability to fight cancer. If you don't have symptoms, you may not need treatment right away. This is called watchful waiting. NIH: National Cancer Institute

MalaCards based summary : Lymphoma, also known as lymphoid neoplasm, is related to lymphoma, non-hodgkin, familial and burkitt lymphoma. An important gene associated with Lymphoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are IL-2 Pathway and PI3K-Akt signaling pathway. The drugs Fosaprepitant and Aprepitant have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Increased viability with MLN4924 (a NAE inhibitor)

Disease Ontology : ¹² A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs.

Wikipedia : ⁷⁴ T-lymphoblastic leukemia/lymphoma (WHO 2008), previously labeled precursor T-lymphoblastic... more...

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Related Diseases for Lymphoma

Diseases in the Lymphoma family:

Adult Lymphoma

Eye Lymphoma

Diseases related to Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2898)

#	Related Disease	Score	Top Affiliating Genes
1	lymphoma, non-hodgkin, familial	36.1	TP53 TCL1A MYC MALT1 CXCR5 CCND1
2	burkitt lymphoma	36.0	TP53 TCL1A PVT1 PMS2 MYC CXCR5
3	follicular lymphoma	36.0	MYC CXCR5 CCND1 BCL6 BCL2 BCL10
4	lymphoma, mucosa-associated lymphoid type	36.0	TP53 MYC MALT1 CXCR5 CCND1 BCL6
5	diffuse large b-cell lymphoma	35.9	TP53 TCL1A MYC MALT1 CCND1 BCL6
6	lymphoma, hodgkin, classic	35.7	PVT1 BCL6 BCL2 ALK
7	peripheral t-cell lymphoma	35.7	TP53 TCL1A CCND1 BCL6 ALK
8	primary central nervous system lymphoma	35.6	CXCR5 BCL6 BCL2
9	gastric lymphoma	35.5	TP53 MALT1 CXCR5 BCL6 BCL10
10	intraocular lymphoma	35.5	CXCR5 BCL6 BCL2
11	lymphoma aids related	35.4	TCL1A MYC BCL6
12	b-cell lymphoma	35.4	TP53 TCL1A PVT1 MYC MALT1 GAS5
13	marginal zone b-cell lymphoma	35.3	MALT1 CCND1 BCL6 BCL10
14	follicular lymphoma 1	35.3	BCL6 BCL2 BCL10
15	central nervous system lymphoma	35.3	TP53 MYC MALT1 CXCR5 BCL6
16	mantle cell lymphoma	35.2	TP53 TCL1A MYC MALT1 GAS5 CCND1
17	lymphoblastic lymphoma	35.2	TP53 MYC BCL6
18	alk-negative anaplastic large cell lymphoma	35.1	MYC BCL2 BAX ALK
19	sezary's disease	35.0	TP53 MYC MALT1 BCL6 BCL10 ALK
20	nodal marginal zone b-cell lymphoma	34.9	MALT1 BCL6 BCL2
21	bone lymphoma	34.8	BCL6 ALK
22	primary mediastinal large b-cell lymphoma	34.8	BCL6 BCL2
23	b-cell non-hodgkin lymphoma	34.8	BCL7A BCL6 ATM
24	plasmablastic lymphoma	34.8	MYC BCL6
25	nodular lymphocyte predominant hodgkin lymphoma	34.8	CCND1 BCL6
26	pediatric lymphoma	34.8	TCL1A MYC BCL6 ALK
27	leukemia, acute lymphoblastic	34.8	TP53 PTPN11 PMS2 MYC CXCR5 BCL6
28	primary cutaneous marginal zone b-cell lymphoma	34.7	MALT1 BCL10
29	gastrointestinal lymphoma	34.7	MALT1 CCND1 BCL6
30	reticulosarcoma	34.7	MYC BCL6 BCL2 ALK
31	adult lymphoma	34.7	MYC BCL6 ALK
32	diffuse large b-cell lymphoma of the central nervous system	34.7	MYC BCL2
33	primary cutaneous cd4+ small/medium-sized pleomorphic t-cell lymphoma	34.7	CXCR5 BCL6
34	intravascular large b-cell lymphoma	34.7	BCL6 BCL2
35	orbit lymphoma	34.7	MALT1 BCL10
36	eye lymphoma	34.7	CXCR5 BCL6
37	lung lymphoma	34.6	MALT1 BCL6
38	b-lymphoblastic leukemia/lymphoma	34.6	PTPN11 MYC ALK
39	gallbladder lymphoma	34.6	MALT1 BCL6
40	t-cell acute lymphoblastic leukemia	34.6	TP53 MYC BCL10 BAX ATM
41	heart lymphoma	34.6	BCL6 ALK
42	breast lymphoma	34.5	BCL6 ALK
43	paranasal sinus lymphoma	34.5	MYC BCL6
44	appendix lymphoma	34.4	MYC BCL6
45	high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement	34.4	MYC BCL6 BCL2
46	t-cell lymphoblastic leukemia/lymphoma	34.1	TCL1A MYC GAS5 CCND1 BCL2
47	precursor t-cell acute lymphoblastic leukemia	34.0	TCL6 TCL1A MYC BCL10 BAX
48	richter's syndrome	33.9	TP53 MYC ATM
49	cll/sll	33.8	TP53 CCND1 BCL6 ATM
50	leukemia, chronic lymphocytic	33.8	TP53 TCL1A PTPN11 MYC DLEU2 CXCR5

Graphical network of the top 20 diseases related to Lymphoma:

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Symptoms & Phenotypes for Lymphoma

GenomeRNAi Phenotypes related to Lymphoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased viability with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.55	ATM BAX BCL2 MALT1 TP53
2	Increased viability with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.55	ATM BAX BCL10 BCL2 CCND1 MALT1
3	Increased viability with MLN4924 (a NAE inhibitor)	GR00250-A-3	9.55	ATM BAX BCL2 TP53

MGI Mouse Phenotypes related to Lymphoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.17	ATM BAX BCL10 BCL2 BCL6 CCND1
2	hematopoietic system	MP:0005397	10.15	ATM BAX BCL10 BCL2 BCL6 CCND1
3	endocrine/exocrine gland	MP:0005379	10.14	ALK ATM BAX BCL10 BCL2 BCL6
4	immune system	MP:0005387	10.1	ATM BAX BCL10 BCL2 BCL6 CCND1
5	mortality/aging	MP:0010768	10.07	ALK ATM BAX BCL10 BCL2 BCL6
6	neoplasm	MP:0002006	9.81	ALK ATM BAX BCL2 CCND1 MYC
7	reproductive system	MP:0005389	9.36	ALK ATM BAX BCL2 BCL6 CCND1
8	pigmentation	MP:0001186	9.35	ALK BCL2 MYC PTPN11 TP53

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Drugs & Therapeutics for Lymphoma

Drugs for Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 864)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Fosaprepitant

Approved

Phase 4

172673-20-0

219090

Aprepitant

Approved, Investigational

Phase 4

170729-80-3

6918365 151165

Ferrous succinate

Approved

Phase 4

10030-90-7

Lisinopril

Approved, Investigational

Phase 4

76547-98-3, 83915-83-7

5362119

Tropisetron

Approved, Investigational

Phase 4

89565-68-4, 105826-92-4

5595

Palonosetron

Approved, Investigational

Phase 4

135729-56-5, 119904-90-4

148211

Teniposide

Approved

Phase 4

29767-20-2

34698

Sirolimus

Approved, Investigational

Phase 4

53123-88-9

5284616 6436030 46835353

Everolimus

Approved

Phase 4

159351-69-6

70789204 6442177

Nitric Oxide

Approved

Phase 4

10102-43-9

145068

Sodium citrate

Approved, Investigational

Phase 4

68-04-2

Omeprazole

Approved, Investigational, Vet_approved

Phase 4

73590-58-6

4594

Rabeprazole

Approved, Investigational

Phase 4

117976-89-3

5029

Adalimumab

Approved

Phase 4

331731-18-1

16219006

Entecavir

Approved, Investigational

Phase 4

142217-69-4

153941

Valsartan

Approved, Investigational

Phase 4

137862-53-4

60846

Nitazoxanide

Approved, Investigational, Vet_approved

Phase 4

55981-09-4

41684

Nitrous oxide

Approved, Vet_approved

Phase 4

10024-97-2

948

Micafungin

Approved, Investigational

Phase 4

235114-32-6

477468 3081921

Posaconazole

Approved, Investigational, Vet_approved

Phase 4

171228-49-2

147912

Penicillin G

Approved, Vet_approved

Phase 4

61-33-6

5904

Tobramycin

Approved, Investigational

Phase 4

32986-56-4

36294 5496

Potassium citrate

Approved, Investigational, Vet_approved

Phase 4

866-84-2

Doxycycline

Approved, Investigational, Vet_approved

Phase 4

564-25-0

54671203

Morphine

Approved, Investigational

Phase 4

57-27-2

5288826

Epirubicin

Approved

Phase 4

56420-45-2

41867

Nicotine

Approved

Phase 4

54-11-5

942 89594

Lithium carbonate

Approved

Phase 4

554-13-2

Lidocaine

Approved, Vet_approved

Phase 4

137-58-6

3676

Prilocaine

Approved

Phase 4

721-50-6

4906

Levofloxacin

Approved, Investigational

Phase 4

100986-85-4

149096

Ofloxacin

Approved

Phase 4

82419-36-1

4583

Fentanyl

Approved, Illicit, Investigational, Vet_approved

Phase 4

437-38-7

3345

Ketamine

Approved, Vet_approved

Phase 4

6740-88-1

3821

Docetaxel

Approved, Investigational

Phase 4

114977-28-5

148124

Clarithromycin

Approved

Phase 4

81103-11-9

84029

Lansoprazole

Approved, Investigational

Phase 4

103577-45-3

3883

Dexlansoprazole

Approved, Investigational

Phase 4

103577-45-3, 138530-94-6

9578005

Glucagon

Approved

Phase 4

16941-32-5

Ketorolac

Approved

Phase 4

66635-83-4, 74103-06-3

3826

Liraglutide

Approved

Phase 4

204656-20-2

44147092

Zidovudine

Approved

Phase 4

30516-87-1

35370

Sargramostim

Approved, Investigational

Phase 4

83869-56-1, 123774-72-1

Valproic acid

Approved, Investigational

Phase 4

99-66-1

3121

Peginterferon alfa-2b

Approved

Phase 4

99210-65-8, 215647-85-1

Ribavirin

Approved

Phase 4

36791-04-5

37542

Amphotericin B

Approved, Investigational

Phase 4

1397-89-3

5280965 14956

Methoxsalen

Approved

Phase 4

298-81-7

4114

Citric acid

Approved, Nutraceutical, Vet_approved

Phase 4

77-92-9

311

Vitamin D

Approved, Nutraceutical, Vet_approved

Phase 4

1406-16-2

Interventional clinical trials:

(show top 50) (show all 7519)

#	Name	Status	NCT ID	Phase	Drugs
1	Comparison of Methotrexate Versus Interferon-alfa 2b on Efficacy, Safety and Quality of Life in Patients With Primary Cutaneous T-cell Lymphomas	Unknown status	NCT02323659	Phase 4	Methotrexate;Interferon Alfa-2b
2	PEG-rhG-CSF in Patients With Non-Hodgkin Lymphoma Receiving Chemotherapy to Prevent Neutropenia	Unknown status	NCT02996617	Phase 4	rhG-CSF regimen;Pegylated rhG-CSF regimen
3	GCSF Plus Plerixafor as First-line Treatment for Autologous Stem Cells Harvest in Children With Malignant Diseases in Need for High-dose Chemotherapy With Stem Cell Rescue.	Unknown status	NCT02006225	Phase 4	Plerixafor
4	A Randomized, Controlled Mutiple-center Clinical Research on the Treatment With Yangzhengxiaoji Capsule Combination Chemotherapy for III/IV Diffuse Large B Cell Lymphoma	Unknown status	NCT01949818	Phase 4	Yangzhengxiaoji capsule combined with CHOP regimen;CHOP regimen
5	The Prospective Study of FVD Program and HD-MTX-Ara-C Program Contrast in the Treatment of PCNSL Lymphoma.	Unknown status	NCT01960192	Phase 4	HD-MTX-Ara-C regimen;FVD regimen
6	Treatment of Elderly Patients With Diffuse Large B-cell Lymphoma	Unknown status	NCT03513601	Phase 4	(R)-CHOP regimen;(R)-CVP regimen
7	Efficacy and Safety of Erythropoietin in the Treatment of Anemia in Patients With Lymphoma After Autologous Hematopoietic Stem Cell Transplantation	Unknown status	NCT03010579	Phase 4	erythropoietin;iron supplementation
8	An Open-label,Multicenter Randomised Study of CTOP/ITE/MTX Compared With CHOP as the First-line Therapy for the New Diagnosed Young Patients With T Cell Non-hodgkin Lymphoma	Unknown status	NCT01746992	Phase 4	Cyclophosphamide 750mg/m2;Vincristine 1.4mg/m2;Doxorubicin 50mg/m2;prednisone 60mg/m2;ifosfamide 2000mg/m2;pirarubicin 50mg/m2;pirarubicin 25mg/m2;Etoposide phosphate 100mg/m2;methotrexate 1500mg/m2
9	A Multicenter Study to Compare the Efficacy of a Prophylactic Use of Tenofovir by Duration for the Non-Hodgkin's Lymphoma Patients With Isolated Anti-HBc-positivity Who Will be Treated With Rituximab Based Chemotherapy	Unknown status	NCT02585947	Phase 4	Tenofovir
10	A Randomized Controlled Multi-center Clinical Trial on Treatment of Stage Ⅲ/Ⅳ NK/T Cell Lymphoma With DDGP Regiment (Gemcitabine,Pegaspargase,Cisplatin,Dexamethasone)	Unknown status	NCT01501149	Phase 4	DDGP(cisplatin,dexamethasone,gemcitabine,pegaspargase);Modified SMILE （MTX，DEX，IFO，L-ASP，Etoposide，Mesna）
11	EDOCH Alternating With DHAP Regimen Combined Rituximab or Not to Treat New Diagnosed Younger (Age≤65 Years) Mantle Cell Lymphoma in China: A Multicentre Phase III Trial	Unknown status	NCT02858804	Phase 4	Etoposide;Doxorubicin;Dexamethasone;Vincristine;Cyclophosphamide;Cytarabine;Cisplatin;Rituximab;Thalidomide;Prednisone
12	Prophylactic Use of Entecavir for HBsAg Positive Lymphoma Patients Treated With Rituximab-based Immunochemotherapy	Unknown status	NCT01768195	Phase 4	Entecavir prophylaxis
13	Prophylactic Use of Entecavir for HBsAg Negative/HBcAb Positive/Hepatitis B Virus DNA Negative Patients With Lymphoma	Unknown status	NCT01765231	Phase 4	Entecavir prophylaxis;Observation arm
14	A Single Center Randomized Controlled Trial of the Efficacy and Safety of PEG-rhG-CSF After Autologous Hematopoietic Stem Cell Transplantation for Lymphoma Patients	Unknown status	NCT02905942	Phase 4	PEG-rhG-CSF;rhG-CSF
15	A Randomized Controlled Multi-center Clinical Trial on Treatment of Stage I/II NK/T Cell Lymphoma With DDGP Regiment (Gemcitabine,Pegaspargase,Cisplatin,Dexamethasone)	Unknown status	NCT01501136	Phase 4
16	Study of Standard and Individualized Treatment Model for Relapse and Refractory Lymphatic System Malignant Tumors	Unknown status	NCT02929615	Phase 4
17	Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults	Unknown status	NCT00797810	Phase 4	Rituximab
18	Evaluation of the Immune Response After Vaccination Against Hepatitis B in Patients With Indolent Lymphoproliferative Disorders With no Treatment.	Unknown status	NCT01698866	Phase 4
19	Optimization of the Primary Therapy for Patients With Hodgkin's Lymphoma and Evaluation of the Positron Emission Tomography (PET) as a Diagnostic Tool for Primary Staging and Assessment of the Effects of the Therapy	Unknown status	NCT00188149	Phase 4	Combined chemotherapy (ABVD, BACOPP-D)
20	Multicenter Study To Optimize Treatment in Elderly Patients (> 55 Years, No Upper Age Limit) With Acute Lymphoblastic Leukemia (GMALL Elderly 1/2003)(Amend 2)	Unknown status	NCT00198978	Phase 4	Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
21	German Multicenter Study for Treatment Optimisation in Acute Lymphoblastic Leukemia in Adults and Adolescents Above 15 Years (Amend 3) (GMALL 07/2003)	Unknown status	NCT00198991	Phase 4	Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
22	A Multi-central Perspective Randomized Controlled Study Evaluating the Efficacy and Safety of Aprepitant in Autologous Hematopoietic Stem Cell Transplantation	Unknown status	NCT02576327	Phase 4	Tropisetron;Dexamethasone;Aprepitant
23	Philadelphia -Negative High-risk Children Acute Lymphoblastic Leukemia(ALL) Treatment:Induction Therapy:Vincristine(V),Idarubicin(I),L-asparaginase(L),Dexamethasone(D);Consolidation:V+Daunorubicin(D)+L+D, Methotrexate,Cytarabine	Unknown status	NCT01990807	Phase 4	Idarubicin(IDA)
24	Ma-Spore ALL 2010 Study	Unknown status	NCT02894645	Phase 4	Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
25	PEG-asparaginase During Two Treatment Courses in the Treatment of Childhood Acute Lymphoblastic Leukemia	Unknown status	NCT00192673	Phase 4	PEG-asparaginase
26	Medical Research Council Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003	Unknown status	NCT00222612	Phase 4	Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
27	The Combination of Lower Dosage of Chemotherapy With Tyrosine Kinase Inhibitor to Treat Newly Diagnosed ph+ Acute Lymphoblastic Leukemia Patients	Unknown status	NCT02690922	Phase 4	Dasatinib;prednisone;dexamethasone;methotrexate
28	Self-control Trial to Evaluate the Role of Aprepitant in the Prophylaxis of Post-lumbar-punture-headache (PLPH)	Unknown status	NCT02347878	Phase 4	Aprepitant
29	Clinical Study of GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia in Guangdong Province	Unknown status	NCT00846703	Phase 4	6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
30	Plasma Kinetics of Tablet and Liquid Formulations of 6-mercaptopurine in Childhood Acute Lymphoblastic Leukemia.	Unknown status	NCT01906671	Phase 4	Xaluprine;Puri-Nethol
31	An Open-label,Multi-center,Prospective Study of Idarubicin and Etoposide Intensified Conditioning Regimen Allogeneic Hematopoietic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia	Unknown status	NCT01873807	Phase 4	IDA;CTX;VP-16
32	Phase 4, Prospective, Randomized and Comparative Study Comparing Sequential and Concomitant Therapy for Helicobacter Pylori Eradication in Routine Clinical Practice	Unknown status	NCT01273441	Phase 4	PPI, amoxicillin, metronidazole and clarithromycin;PPI, amoxicillin, metronidazole and clarithromycin
33	Study of the Relationship Between the Rate of Residual Platinum in the Blood and the Incidence of Persistent Neurotoxicity in Patients Treated for Gastrointestinal Cancer With Oxaliplatin	Unknown status	NCT00274885	Phase 4	oxaliplatin
34	Prophylactic Lisinopril to Prevent Anthracycline Induced Left Ventricular Systolic Dysfunction (PLAID) Study.	Unknown status	NCT03392740	Phase 4	Lisinopril;Placebo Oral Tablet
35	A Phase 4, Randomized, Open-Label Study to Assess Humoral and Intestinal Polio Immunity Following a Three-Dose Trivalent Inactivated Polio Vaccine Schedule Relative to Two Sequential Schedules of IPV/Bivalent Oral Polio Vaccines	Unknown status	NCT01841671	Phase 4
36	Estimation of Carbohydrate Metabolism Disorder Frequency in Hypertriglyceridemia Induced by Bexarotene Treatment of Cutaneous T Cell Lymphoma - Pilote Study	Completed	NCT01569724	Phase 4
37	Evaluation of Allogeneic Marrow Transplants Depleted of T-Cells by CD34+ Selection in Patients Undergoing Transplantation With an Unrelated Matched or 1 Antigen Mismatched Donor or a 1 Antigen Mismatched Related Donor	Completed	NCT00003398	Phase 4	cyclophosphamide;thiotepa
38	The Multi-center,Open-label,Single Arm Clinical Trial of Efficacy and Safety of PEG-rhG-CSF in Patients With Lymphoma Receiving Chemotherapy	Completed	NCT02805218	Phase 4	PEG-rhG-CSF
39	A RANDOMIZED PHASE 4 STUDY COMPARING 2 INTRAVENOUS TEMSIROLIMUS (TEMSR) REGIMENS IN SUBJECTS WITH RELAPSED, REFRACTORY MANTLE CELL LYMPHOMA	Completed	NCT01180049	Phase 4	temsirolimus;temsirolimus
40	AMENO-2: Fase IV Study, National, Multiple Centers, Competitive, Randomized, Double Blind, Controlled With Parallel Groups to Determinate the Security, Tolerability and Efficacy of Aprepitant Plus Palonosetron Versus Granisetron in the Prevention of Nausea and the Emesis Induced by Chemotherapy in Patients Treated With Haematopoietic Progenitors	Completed	NCT00415103	Phase 4	Aprepitant;Palonosetron;Granisetron
41	Study Evaluating Rapid Infusion Rituximab in Patients With Autoimmune Diseases	Completed	NCT02040116	Phase 4	Rituximab Infusion
42	Multicenter Study to Optimise Therapy of B-ALL, Burkitt's NHL and High-Grade Non-Hodgkin's Lymphoma in Adults (Amend 7)	Completed	NCT00199082	Phase 4	Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
43	A Multicenter Study to Evaluate the Effect of Rituximab (IDEC-102) on Primary Humoral Response, Recall Response, and Maintenance of Acquired Immunity to Specific Antigens	Completed	NCT00090038	Phase 4	rituximab
44	HTLV-I Associated Adult T-cell Leukaemia/Lymphoma (ATLL) Pilot Study of Combination Therapy With CHOP-Zenapax (CHOP-daclizumab)	Completed	NCT01418430	Phase 4	CHOP-daclizumab
45	A Study to Evaluate the Safety of MabThera (Rituximab) Maintenance Therapy in Patients With Follicular Non-Hodgkin's Lymphoma Who Have Responded to Induction Therapy.	Completed	NCT00430352	Phase 4	rituximab [MabThera/Rituxan]
46	Phase IV Randomized Study of Two Dose Levels of Targretin® Capsules in Subjects With Refractory Cutaneous T-Cell Lymphoma	Completed	NCT01007448	Phase 4	Bexarotene
47	Open Label Study of ONTAK® (Denileukin Diftitox, DAB389IL-2) to Estimate Response in Cutaneous T-Cell Lymphoma (CTCL) According to CD25 Status	Completed	NCT00211198	Phase 4	ONTAK (denileukin difitox, DAB389IL-2)
48	Multicenter Trial for Treatment Optimization in T-lymphoblastic Lymphoma in Adults and Adolescents Older Than 15 Years (GMALL T-LBL 1/2004) (Amend 1)	Completed	NCT00199017	Phase 4	Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
49	A Multicenter Open-Label Study to Evaluate the Safety and Efficacy of DAB389IL-2 in Cutaneous T-Cell Lymphoma (CTCL) Patients Following Protocol 93-04-10, Protocol 93-04-11, or Protocol 92-04-01 or Who Meet the Requirements for Protocol 93-04-11 Except Have Biopsy-Documented CTCL That Does Not Express CD25	Completed	NCT00051012	Phase 4	ONTAK
50	A Multicenter Phase III Randomized Double-Blind Placebo-Controlled Study to Evaluate the Efficacy of Two Dose Levels of DAB389IL-2 (9 and 18 Mcg/kg/Day) in Cutaneous T-Cell Lymphoma (CTCL) Patients With Stage Ia-III Disease Who, Following Less Than or Equal to 3 Previous Therapies, Have Recurrent or Persistent Disease That Has Been Biopsy-Documented to Express CD25	Completed	NCT00050999	Phase 4	ONTAK

Search NIH Clinical Center for Lymphoma

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

ASPARAGINASE

Cytarabine

Cytarabine liposome

irinotecan

Irinotecan hydrochloride

Mitoxantrone

Mitoxantrone Hydrochloride

Thiotepa

Cochrane evidence based reviews: lymphoma

Sources

Genetic Tests for Lymphoma

Genetic tests related to Lymphoma:

#	Genetic test	Affiliating Genes
1	Lymphoma ²⁹

Sources

Anatomical Context for Lymphoma

MalaCards organs/tissues related to Lymphoma:

⁴⁰

B Cells, T Cells, Bone, Bone Marrow, Lung, Breast, Thyroid

Sources

Publications for Lymphoma

Articles related to Lymphoma:

(show top 50) (show all 58134)

#	Title	Authors	PMID	Year
1	Diagnostic approach in hepatic lymphoma: radiological imaging findings and literature review. ⁴²	Ippolito D...Sironi S	32296934	2020
2	Pancreas Solid Tumors. ⁴²	Younan G	32402301	2020
3	Molecular imaging in lymphoma beyond 18F-FDG-PET: understanding the biology and its implications for diagnostics and therapy. ⁴²	Kahle XU...Nijland M	32470439	2020
4	Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas. ⁵⁴ ⁶¹	Bhatt AP...Damania B	20299510	2010
5	Notch1 in primary effusion lymphoma: a clinicopathological study. ⁶¹ ⁵⁴	Wang HY...Karandikar NJ	20348880	2010
6	Common misdiagnoses in lymphomas and avoidance strategies. ⁵⁴ ⁶¹	Chan JK...Kwong YL	20227918	2010
7	Oncogenic activation of NF-kappaB. ⁶¹ ⁵⁴	Staudt LM	20516126	2010
8	Loss of p73 promotes dissemination of Myc-induced B cell lymphomas in mice. ⁶¹ ⁵⁴	Nemajerova A...Moll UM	20484818	2010
9	Natural killer-cell receptor polymorphisms and posttransplantation non-Hodgkin lymphoma. ⁶¹ ⁵⁴	Stern M...Hess C	20207982	2010
10	Histone acetyltransferase p300 is a coactivator for transcription factor REL and is C-terminally truncated in the human diffuse large B-cell lymphoma cell line RC-K8. ⁶¹ ⁵⁴	Garbati MR...Gilmore TD	19948376	2010
11	C/EBPβ expression in ALK-positive anaplastic large cell lymphomas is required for cell proliferation and is induced by the STAT3 signaling pathway. ⁵⁴ ⁶¹	Anastasov N...Quintanilla-Martinez L	20015877	2010
12	Rac1 targeting suppresses p53 deficiency-mediated lymphomagenesis. ⁵⁴ ⁶¹	Bosco EE...Zheng Y	20179179	2010
13	Adult T-cell leukemia/lymphoma development in HTLV-1-infected humanized SCID mice. ⁶¹ ⁵⁴	Banerjee P...Feuer G	20124219	2010
14	Anaplastic lymphoma kinase as a therapeutic target in anaplastic large cell lymphoma, non-small cell lung cancer and neuroblastoma. ⁵⁴ ⁶¹	Cheng M...Ott GR	20406193	2010
15	Fine needle aspiration cytology of ALK1(-), CD30+ anaplastic large cell lymphoma post renal transplantation: a case report and literature review. ⁵⁴ ⁶¹	Balachandran I...Broman J	19774614	2010
16	C-C chemokine receptor 1 expression in human hematolymphoid neoplasia. ⁶¹ ⁵⁴	Anderson MW...Natkunam Y	20154287	2010
17	Characterization of D-cyclin proteins in hematolymphoid neoplasms: lack of specificity of cyclin-D2 and D3 expression in lymphoma subtypes. ⁵⁴ ⁶¹	Metcalf RA...Natkunam Y	20062012	2010
18	BCL6, MUM1, and CD10 expression in mantle cell lymphoma. ⁵⁴ ⁶¹	Gualco G...Bacchi CE	19826251	2010
19	An uncommon case of de novo CD10+ CD5- mantle cell lymphoma mimics follicle center B cell lymphoma. ⁶¹ ⁵⁴	Zapata M...Li S	20490333	2010
20	Sodium valproate in combination with ganciclovir induces lysis of EBV-infected lymphoma cells without impairing EBV-specific T-cell immunity. ⁵⁴ ⁶¹	Jones K...Gandhi MK	19196381	2010
21	Determining the expression rate of the IgM and IgA in B cell lymphomas by immunohistochemistry. ⁶¹ ⁵⁴	Fakhrjou A...Bozorgi F	20437688	2010
22	PD-1 expression in T-cell lymphomas and reactive lymphoid entities: potential overlap in staining patterns between lymphoma and viral lymphadenitis. ⁵⁴ ⁶¹	Krishnan C...Natkunam Y	20087161	2010
23	CD81 protein is expressed at high levels in normal germinal center B cells and in subtypes of human lymphomas. ⁶¹ ⁵⁴	Luo RF...Natkunam Y	20004001	2010
24	Expression profiling of transcription factors in B- or T-acute lymphoblastic leukemia/lymphoma and burkitt lymphoma: usefulness of PAX5 immunostaining as pan-Pre-B-cell marker. ⁶¹ ⁵⁴	Nasr MR...Syrbu S	20023257	2010
25	[Expression and function of TRAF1 in Hodgkin's lymphoma cells.]. ⁶¹ ⁵⁴	Wang WJ...Ma L	20302775	2010
26	Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. ⁶¹ ⁵⁴	Davis RE...Staudt LM	20054396	2010
27	Lymphoma cells contribute to the augmentation of plasma sL-selectins in the serum of lymphoma-bearing mice. ⁶¹ ⁵⁴	Aube C...St-Pierre Y	20001233	2010
28	Anomalous constitutive Src kinase activity promotes B lymphoma survival and growth. ⁵⁴ ⁶¹	Ke J...Bondada S	20043832	2009
29	To the genesis of Burkitt lymphoma: regulation of apoptosis by EBNA-1 and SAP may determine the fate of Ig-myc translocation carrying B lymphocytes. ⁶¹ ⁵⁴	Nagy N...Klein E	19874894	2009
30	Nodal diffuse large B-cell lymphomas in children and adolescents: immunohistochemical expression patterns and c-MYC translocation in relation to clinical outcome. ⁵⁴ ⁶¹	Gualco G...Bacchi CE	19816150	2009
31	Expression of Grb2 distinguishes classical Hodgkin lymphomas from primary mediastinal B-cell lymphomas and other diffuse large B-cell lymphomas. ⁵⁴ ⁶¹	Miles RR...Lim MS	19716163	2009
32	Three clinical-stage tumor targeting antibodies reveal differential expression of oncofetal fibronectin and tenascin-C isoforms in human lymphoma. ⁵⁴ ⁶¹	Schliemann C...Neri D	19625084	2009
33	Anaplastic large cell lymphoma: one or more entities among T-cell lymphoma? ⁵⁴ ⁶¹	Fornari A...Inghirami G	19358142	2009
34	Temsirolimus in mantle cell lymphoma and other non-Hodgkin lymphoma subtypes. ⁵⁴ ⁶¹	Hess G...Coiffier B	19963099	2009
35	A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas. ⁶¹ ⁵⁴	Cerchietti LC...Melnick A	19966776	2009
36	[Immunohistochemical study using T-cell lymphoma antibody 1 and CD44 in diagnosis of Burkitt's lymphoma]. ⁶¹ ⁵⁴	Shui RH...Zhu XZ	20079013	2009
37	Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma. ⁵⁴ ⁶¹	Dictor M...Borrebaeck C	19880779	2009
38	SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype. ⁵⁴ ⁶¹	Mozos A...Campo E	19880778	2009
39	Differential diagnosis of cyclin D2+ mantle cell lymphoma based on fluorescence in situ hybridization and quantitative real-time-PCR. ⁶¹ ⁵⁴	Quintanilla-Martinez L...Fend F	19608671	2009
40	Multiple isoforms of PAX5 are expressed in both lymphomas and normal B-cells. ⁵⁴ ⁶¹	Arseneau JR...Ouellette RJ	19725825	2009
41	Targeted deletion of p73 in mice reveals its role in T cell development and lymphomagenesis. ⁶¹ ⁵⁴	Nemajerova A...Petrenko O	19907659	2009
42	The mechanisms underlying MMR deficiency in immunodeficiency-related non-Hodgkin lymphomas are different from those in other sporadic microsatellite instable neoplasms. ⁶¹ ⁵⁴	Borie C...Duval A	19551857	2009
43	CD44 expression during tumor progression of follicular lymphoma. ⁶¹ ⁵⁴	Higashi M...Harigaya K	19787231	2009
44	Genetic variation in the NBS1, MRE11, RAD50 and BLM genes and susceptibility to non-Hodgkin lymphoma. ⁶¹ ⁵⁴	Schuetz JM...Brooks-Wilson AR	19917125	2009
45	Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of t(14;18)-negative follicular lymphoma. ⁵⁴ ⁶¹	Chiu A...Orazi A	19633642	2009
46	AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. ⁶¹ ⁵⁴	Robbiani DF...Nussenzweig MC	19941823	2009
47	Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells. ⁵⁴ ⁶¹	Richter K...Diaz M	19734146	2009
48	Identification of MNDA as a new marker for nodal marginal zone lymphoma. ⁵⁴ ⁶¹	Kanellis G...Piris MA	19474799	2009
49	Functional signatures identified in B-cell non-Hodgkin lymphoma profiles. ⁶¹ ⁵⁴	Aggarwal M...Piris MA	19863341	2009
50	P38 mitogen activated protein kinase expression and regulation by interleukin-4 in human B cell non-Hodgkin lymphomas. ⁶¹ ⁵⁴	Ding H...Elenitoba-Johnson KS	20309428	2009

Sources

Genes for Lymphoma

Genes related to Lymphoma (3 elite genes):

(show top 50) (show all 170)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	TP53	Tumor Protein P53	Protein Coding	434.39	Pathogenic ⁶ DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Variants (show sections)	1466398 19650989 9662328 (more) 7661603 11230707 10664623 8924223 10539880 8685222 16773959 9437796 7718450 8637726 15276860 19608668 8338955 7753548 16401344 9464543 8603336 7699210 9044511 9800187 19596268 12840870 10541553 7964649 15882401 11712681 11498763 9424736 17587242 15168595 1680118 7631541 7894617 12383214 9136910 7730485 8107196 8579126 10534160 10845931 10200502 7599045 8129043 19589272 16169462 12217802 10084308 17609875 16007185 16094360 9741539 9638983 8978599 7741100 9360843 8639789 8305226 8400252 1772779 8623759 12414343 9719458 9326189 9589459 9542595 9042396 8018922 8314342 18765533 16461462 11841384 10639591 9375758 10567774 19680549 17284530 17251932 15713979 12812137 11699208 7482119 10403275 16682948 11896204 9416841 8499637 7723400 9498719 12530577 12505318 11818669 11748353 11676855 11352401 11035575 10780666
2	PMS2	PMS1 Homolog 2, Mismatch Repair System Component	Protein Coding	423.89	Pathogenic ⁶ DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Variants (show sections)	12400605 17601929 10498885
3	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	423.47	Pathogenic ⁶ DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Variants (show sections)	17483340 18192401 12531430 (more) 19798502
4	TCL6	T Cell Leukemia/Lymphoma 6	RNA Gene	181.51	Experimental evidence ³⁸ DISEASES inferred ¹⁵ GeneCards inferred via : Gene name Summaries Proteins (show sections)	10851082
5	PVT1	Pvt1 Oncogene	RNA Gene	171.71	Experimental evidence ³⁸ DISEASES inferred ¹⁵ GeneCards inferred via : Publications Summaries (show sections)	2470097 3024964
6	GAS5	Growth Arrest Specific 5	RNA Gene	155.88	Experimental evidence: Regulation ³⁸ DISEASES inferred ¹⁵	18406879 18836484 24703244
7	SNHG5	Small Nucleolar RNA Host Gene 5	RNA Gene	155.15	Experimental evidence: Locus ³⁸ DISEASES inferred ¹⁵	10792466
8	DLEU2	Deleted In Lymphocytic Leukemia 2	RNA Gene	154.38	Experimental evidence: Regulation ³⁸ DISEASES inferred ¹⁵	11072235 19591824
9	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	102.38	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Gene name Summaries Functions Drugs & Compounds Variants Domains & Families (show sections)	10383129 19734424 19432678 (more) 19386350 9415224 7655001 10994999 10505771 10807789 12401829 18788887 18451166 15948671 12920229 10555007 9736036 11395553 16434370 14631806 16604305 16776978 9638979 9490693 20190816 19459784 19275511 17509395 15928040 15938644 15583856 10339500 19393834 17681947 17439836 16105984 16226988 15297972 15188137 12107166 10886208 14692518 14569815 11172201 20227918 19393833 17904822 17490616 17111047 16677010 16451066 15602716 15972965 11809760 11561161 11278720 20146901 19825801 17168442 16758729 16189272 15778844 15887977 12202671 11850821 11729213 8781433 11280613 8122112 17694547 18070884 18097461 12889041 12122009 19815557 18974134 16435287 12555065 20406193 18469826 17720243 17332315 18549625 19131793 18674914 10786813 10929023 10975933 12717253 15161657 16151469 16049513 15908427 15886198 15475930 15512815 15492998 15208656 15245952 15609686 15297316 15080301 14692525
10	BCL6	BCL6 Transcription Repressor	Protein Coding	83.98	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Gene name Summaries Proteins Functions (show sections)	9373196 8703825 9209377 (more) 15375218 12399978 10626250 9044511 15252312 10414499 10764139 12414651 16185497 19966776 10887128 9200999 7472775 17468402 16019457 12399977 11742039 9184180 12217802 10936424 10923927 9892104 9824206 15894265 12407182 11157493 19525926 12760796 8623923 8208268 14513282 9600597 19236753 16819511 14674895 17785208 18264083 12881702 8555467 9382982 12430874 12775568 17175383 19797315 15385936 15256116 12515714 12378521 12191569 11854457 11821949 11342629 9395180 10090923 9747876 9401082 7639334 20510734 18451163 17573669 17545502 17360630 16494623 15892171 12835729 12579992 11943722 11380473 10406897 9398863 9310496 16633785 14690607 12413700 11133771 10981963 10702417 10396291 10193956 16400323 16647949 16142238 14654791 12517536 11120780 18784824 19826251 19103865 18452090 17558410 17254814 16815642 16331266 15377470 20079013 19816150 16730063 12171495
11	BCL10	BCL10 Immune Signaling Adaptor	Protein Coding	80.12	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Gene name Summaries Proteins Functions Variants (show sections)	16310461 11748643 10582682 (more) 18346354 11830492 12950026 9989495 16177990 20235165 11425462 10380920 19696203 18583339 15337797 18252714 16785131 11372735 10790217 17356384 11455987 11237074 14716524 11066079 18550498 11356195 17540779 19174606 10803524 10942247 11079291 11466612
12	CXCR5	C-X-C Motif Chemokine Receptor 5	Protein Coding	63.27	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Gene name Summaries Functions Expressions Domains & Families (show sections)	12578791 8405054 7920182 (more) 19536742 11368435 14971583 19228923
13	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	63.12	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries Functions Variants (show sections)	11431360 8919541 9196434 (more) 2200538 8615659 18461184 9044511 19174520 10706881 17718267 1769408 19026697 1652978 9169090 1639541 10658480 11163079 10602433 17942906 17310999 15958595 12213716 10819980 1638027 17230227 16169462 9719630 17664422 18535662 17368758 12580957 19197161 11699208 8713579 17786344 7597296 18471881 12169201 9563496 2320412 1495494 12801300 15735016 20161707 17984302 12481006 11697627 10233417 8847898 7564520 7812011 8260894 2070052 9719458 9662328 9600597 8043869 8025516 2056771 1992441 2189291 14563837 8758892 8695812 7535586 8265096 8515068 2170898 19064702 18765521 16616107 14515211 12151601 10435590 8620470 7812182 8286743 8274734 1493439 1387833 17639584 17786314 16541139 16855632 16690525 15150404 15104301 12517816 11526483 10527691 9395180 9036941 8353142 1321486 1321271 20079013 18713946 18398742 18281035
14	MALT1	MALT1 Paracaspase	Protein Coding	61.28	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Gene name Proteins Functions (show sections)	19394813 11066071 12560219 (more) 10702396 17199743 15150097 14652825 17451356 15210867 11197361
15	CCND1	Cyclin D1	Protein Coding	59.57	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Gene name Functions (show sections)	9291459 19963099 8619427 (more) 9697882 8704183 7540362 12591969 11159766 11291051 1682919 8764748 8045522 10478136 18303407 9376597 12417084 9436924 9258602 1394169 15974819 12710892 9652725 9028328 12515730 2207314 9234379 8774476 12411587 10773403 10733493 7545645 16925576 8426754 11863220 10602433 9140288 18685613 12665688 7591969 1461646 1518159 19783727 11903572 11881727 11699208 9831207 2070085 16082258 10463985 10217569 7597296 8172823 17018901 18552173 16203276 17934069 20490333 19198627 17022831 12430874 8575852 9753060 15726593 11902564 11722998 11697627 10482983 10361135 10233383 10622539 10095879 8740788 18709664 17722077 17556072 17203162 16847683 16321849 16280659 16093790 16001955 16393687 15951302 15578074 14961037 14678979 14514791 12231535 10874676 10851921 10627471 9499444 9640844 9209653 7531681 7961120 20062013 19826251 19608671 17316759 9888704
16	BCL2	BCL2 Apoptosis Regulator	Protein Coding	57.88	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Gene name Summaries Variants (show sections)	8667654 8774139 8703825 (more) 16373664 1890741 11431360 8371594 9758366 7605982 17043638 18695675 7706514 1900270 2252103 9192822 1902122 19004807 9276187 9587934 9413633 8084613 19060243 10414499 9368670 7819053 15713621 9592254 9169090 9713967 7730485 2207314 1643614 1951841 8624457 8685041 12970736 9235968 7751474 7959648 2208029 19242522 15676141 15377339 11276370 11234896 10692454 8948292 8623759 15634664 15359912 12637941 9600597 9573034 7597296 16076491 18375822 14674895 16547596 15770300 11431352 10530711 9157989 7631541 7642169 8106752 8798441 7950302 17368758 11298531 10515230 7509210 8426481 1916688 15880597 11836434 11699208 10598877 1453000 2129304 2201196 8436340 9846961 9787151 11243121 1909295 8422456 8080035 9867250 10219790 1581586 19684859 19196496 19022754 19363496 18945749 18362516 17256834 17132110 18827561 18264083 18275607 17484779
17	BCL7A	BAF Chromatin Remodeling Complex Subunit BCL7A	Protein Coding	57.21	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Summaries Proteins Functions (show sections)
18	TCL1A	TCL1 Family AKT Coactivator A	Protein Coding	55.36	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Gene name Proteins Functions (show sections)	11709712 10792782 11304575 (more) 19147787 16978196 10786666 12874873 12969959 7809072 11607815 10680598 10449776 16146820 20079013 11710897 11752899 17548807
19	ATM	ATM Serine/Threonine Kinase	Protein Coding	52.34	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Functions Variants (show sections)	12149228 12505357 11429421 (more) 8843194 12513844 14607769 14628072 9622061 19404735 14735203 10706620 9573030 10716718 9537233 10397742 16053658 10507849 12393693 18679420 15548996 16631465
20	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	47.26	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Functions Expressions Variants (show sections)	15854132 9720096 10598877 (more) 18778369 10612806 9583678 9867250 10219790 19251084 19885011 9376600 12210808 18316580 12580957 9703886 11603921 11025591 18487654 14515211 16467110 9705131 17897817 19723045 18375822 20034411 17418025 16546908 15359630 14991542 18174961 9712423 16840578 19723537 9713967 10664622 11726649
21	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	44.87	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Gene name Proteins Functions (show sections)	17376711 12974090 16801538 (more) 17132223 17822624 15340013 19923095 19246286 9268346
22	BCL11B	BAF Chromatin Remodeling Complex Subunit BCL11B	Protein Coding	43.49	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Gene name Proteins Expressions (show sections)	17173069 12565905
23	BCL3	BCL3 Transcription Coactivator	Protein Coding	42.84	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Gene name Proteins (show sections)	8400234 15105810 7642169 (more) 16108830 16123212 8011990 16533741
24	NPM1	Nucleophosmin 1	Protein Coding	41.03	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Functions (show sections)	8187071 17488663 8859196 (more) 15233906 11280786 9121481 17608768 11110708 16049513 19088198 8562933 9331298 9736036 15297972 11888936 10994999 9844824 8562957 19459784 16103750 16101126 10216106 15680399 11561161 10362790 10555007 9598798 9250148 9187427 9057650 8122112 17464320 16189272 9174053 8781434 8781433 7662979 12555065 9643564 7579458 18776764 14563642 9274957 9053841 20015877 19393833 17353907 17560012 17111047 18070884 17695725 12213716 9885226 9819383 7780128 7856744 19358142 9638979 9209644 7772531 16596703 16888916 15208656 11395396
25	CASP10	Caspase 10	Protein Coding	40.87	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)	17071630
26	PAX5	Paired Box 5	Protein Coding	39.52	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Functions (show sections)	19368954 9694719 9808580 (more) 9850179 19100628 15832095 17717432 15385562 17717600 19669194 14676435 16799206 20023257 16968900 7511679 17529924 16778825 16541139 17682124 19725825 17339148 11975116 19806612 17431414 19430986
27	GCSAM	Germinal Center Associated Signaling And Motility	Protein Coding	39.42	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Gene name Functions Expressions (show sections)
28	BCL11A	BAF Chromatin Remodeling Complex Subunit BCL11A	Protein Coding	39.12	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Gene name Summaries Proteins (show sections)
29	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	38.92	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
30	ZC3H12D	Zinc Finger CCCH-Type Containing 12D	Protein Coding	38.47	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Expressions (show sections)
31	SH2D1A	SH2 Domain Containing 1A	Protein Coding	38.31	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)	11493483 11213803 11258422 (more) 19874894 19738428 19150402
32	PARP9	Poly(ADP-Ribose) Polymerase Family Member 9	Protein Coding	38.25	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Functions (show sections)
33	MIA2	MIA SH3 Domain ER Export Factor 2	Protein Coding	38.01	DISEASES inferred ¹⁵ ¹⁵ GeneCards inferred via : Disorders Publications Gene name Expressions (show sections)
34	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	37.9	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications (show sections)	9150386 10713675 9021684 (more) 7597296 7651435 9523851
35	KLHDC8B	Kelch Domain Containing 8B	Protein Coding	37.74	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
36	CTAGE1	Cutaneous T Cell Lymphoma-Associated Antigen 1	Protein Coding	37.7	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Gene name Proteins Expressions (show sections)
37	RNF213	Ring Finger Protein 213	Protein Coding	36.84	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Summaries (show sections)
38	BCL7C	BAF Chromatin Remodeling Complex Subunit BCL7C	Protein Coding	36.77	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Gene name Summaries Proteins (show sections)
39	BCL7B	BAF Chromatin Remodeling Complex Subunit BCL7B	Protein Coding	36.54	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Gene name Summaries Proteins (show sections)
40	EZH2	Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit	Protein Coding	36.43	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Expressions Variants (show sections)	17138155 15856046 14532106 (more) 11298590 16361539
41	ZMYM2	Zinc Finger MYM-Type Containing 2	Protein Coding	36.39	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)	9425908 10887137
42	KDSR	3-Ketodihydrosphingosine Reductase	Protein Coding	36.22	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Summaries (show sections)
43	TIAM2	TIAM Rac1 Associated GEF 2	Protein Coding	36.16	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Gene name Proteins Functions (show sections)
44	NKAIN2	Sodium/Potassium Transporting ATPase Interacting 2	Protein Coding	36.13	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Summaries (show sections)
45	PIM2	Pim-2 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	35.99	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Functions Expressions (show sections)	16403219 18467333
46	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	35.94	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	8055109 10595933 11594583 (more) 1330287 19131793 10628334 15356338 11121138 2240355 1376944 8183550 7982672 10786813 8960041 1337078 9824099 19823169 19540595 16482992 15148593 8693905 8964173 8547075 7615247 8604686 7849284 7690736 19091487 15894695 12648233 11097375 9415340 9085151 7745117 16140928 11729213 10908157 8919540 1724356 2159438 19031716 12652196 15132850 12579989 11493472 10452512 20010405 10975933 11882963 11891807 12717253 12855655 18223553
47	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	35.12	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Summaries Functions (show sections)	17138822 2103511 11287119 (more) 15644776
48	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	34.32	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)	9425908 10486218 10887137 (more) 16305489 19506298
49	CXCL13	C-X-C Motif Chemokine Ligand 13	Protein Coding	33.83	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Gene name Summaries (show sections)	16086967 11710719
50	CBL	Cbl Proto-Oncogene	Protein Coding	33.82	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Gene name Variants (show sections)	17704644 14530346 16289966 (more) 17391982 20038312 16858728 8649859 16493086

Sources

Variations for Lymphoma

ClinVar genetic disease variations for Lymphoma:

⁶ (show all 15) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	TP53	NM_000546.6(TP53):c.743G>A (p.Arg248Gln)	SNV	Pathogenic	12356	rs11540652	17:7577538-7577538	17:7674220-7674220
2	PTPN11	NM_002834.5(PTPN11):c.188A>G (p.Tyr63Cys)	SNV	Pathogenic	13333	rs121918459	12:112888172-112888172	12:112450368-112450368
3	PMS2	NM_000535.7(PMS2):c.1831dup (p.Ile611fs)	duplication	Pathogenic	91317	rs63750250	7:6026564-6026565	7:5986933-5986934
4	PMS2	NM_000535.7(PMS2):c.736_741delinsTGTGTGTGAAG (p.Pro246_Pro247delinsCysValTer)	indel	Pathogenic	91366	rs267608150	7:6037019-6037024	7:5997388-5997393
5	EZH2	NM_004456.4(EZH2):c.1936T>A (p.Tyr646Asn)	SNV	Likely pathogenic	376217	rs267601395	7:148508728-148508728	7:148811636-148811636
6	EZH2	NM_004456.4(EZH2):c.1937A>C (p.Tyr646Ser)	SNV	Likely pathogenic	376218	rs267601394	7:148508727-148508727	7:148811635-148811635
7	EZH2	NM_004456.4(EZH2):c.2045C>G (p.Ala682Gly)	SNV	Likely pathogenic	376219	rs1057519833	7:148506467-148506467	7:148809375-148809375
8	EZH2	NM_004456.5(EZH2):c.1937A>T (p.Tyr646Phe)	SNV	Likely pathogenic	76768	rs267601394	7:148508727-148508727	7:148811635-148811635
9	EZH2	NM_004456.5(EZH2):c.1936T>C (p.Tyr646His)	SNV	Likely pathogenic	76769	rs267601395	7:148508728-148508728	7:148811636-148811636
10	KMT2D	NM_003482.3(KMT2D):c.11897_11911del (p.Phe3966_Gln3971delinsTer)	deletion	Likely pathogenic	638280		12:49426577-49426591	12:49032794-49032808
11	KMT2D	NM_003482.3(KMT2D):c.10622_10623CT[1] (p.Leu3542fs)	short repeat	Likely pathogenic	638279		12:49427965-49427966	12:49034182-49034183
12	SETBP1	NM_015559.3(SETBP1):c.1703G>T (p.Ser568Ile)	SNV	Likely pathogenic	638281		18:42531008-42531008	18:44951043-44951043
13	IDH1	NM_001282386.1(IDH1):c.784G>A (p.Glu262Lys)	SNV	Uncertain significance	638277		2:209106784-209106784	2:208242060-208242060
14	NSD2	NM_001042424.3(NSD2):c.3295G>A (p.Glu1099Lys)	SNV	Uncertain significance	638278		4:1962801-1962801	4:1961074-1961074
15	MYD88	NM_002468.5(MYD88):c.755T>C (p.Leu252Pro)	SNV	Uncertain significance	37055	rs387907272	3:38182641-38182641	3:38141150-38141150

Cosmic variations for Lymphoma:

⁹

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM143780282		haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,Hodgkin lymphoma	c.2209C>A	p.Q737K	6:137881155-137881155	16

Copy number variations for Lymphoma from CNVD:

⁷ (show all 24)

#	CNVD ID	Chromosome	Start	End	Type	Gene Symbol	CNVD Disease
1	22797	1	168900	170100	Copy number		Lymphoma
2	23565	1	171600	171900	Copy number		Lymphoma
3	23675	1	172800	176700	Copy number		Lymphoma
4	25326	1	187500	188100	Copy number		Lymphoma
5	82146	14	105300	105900	Copy number		Lymphoma
6	83536	14	21300	22200	Copy number		Lymphoma
7	149232	2	88800	89400	Copy number		Lymphoma
8	159014	21	39019555	39028514	Amplification	KCNJ6	Lymphoma
9	159212	21	41403021	41411848	Amplification	DSCAM	Lymphoma
10	159621	21	43701285	43716936	Amplification	ABCG1	Lymphoma
11	159656	21	43999157	44011961	Amplification	SLC37A1	Lymphoma
12	159668	21	44081762	44094899	Amplification	PDE9A	Lymphoma
13	159699	21	44433424	44441413	Amplification	PKNOX1	Lymphoma
14	159719	21	44574984	44589646	Amplification		Lymphoma
15	159916	21	45919335	45928378	Amplification	C21orf29	Lymphoma
16	159943	21	46246130	46270192	Amplification	PTTG1IP	Lymphoma
17	162160	22	21300	21600	Copy number		Lymphoma
18	205715	6	13200	17100	Copy number		Lymphoma
19	208659	6	1800	4200	Copy number		Lymphoma
20	208796	6	19800	23100	Copy number		Lymphoma
21	213994	6	5400	6300	Copy number		Lymphoma
22	220996	7	141900	142200	Copy number		Lymphoma
23	224818	7	38100	38700	Copy number		Lymphoma
24	233910	8	128816946	128822855	Amplification	MYC	Lymphoma

Sources

Expression for Lymphoma

Search GEO for disease gene expression data for Lymphoma.

Sources

Pathways for Lymphoma

Pathways related to Lymphoma according to GeneCards Suite gene sharing:

(show top 50) (show all 62)

#	Super pathways	Score	Top Affiliating Genes
1	IL-2 Pathway ⁶³ Show member pathways ErbB Family Pathway ⁶³ ErbB2-ErbB3 Heterodimers ⁶³ ErbB4 Pathway ⁶³ Growth Hormone Signaling ⁶³ HMGB1 Pathway ⁶³ IL-4 Pathway ⁶³ LPS Stimulated MAPK Signaling ⁶³ PACAP Signaling ⁶³ PI3K Signaling in B-Lymphocyte ⁶³ Prolactin Signaling ⁶³ Thrombopoietin Pathway ⁶³ TREM1 Pathway ⁶³ UVC-Induced MAPK Signaling ⁶³	13.23	TP53 MYC MALT1 CCND1 BCL2 BCL10
2	PI3K-Akt signaling pathway ³⁶ Show member pathways Human papillomavirus infection ³⁶	12.97	TP53 TCL1A MYC CCND1 BCL2 BAX
3	Human cytomegalovirus infection ³⁶ Show member pathways Human immunodeficiency virus 1 infection ³⁶ Kaposi sarcoma-associated herpesvirus infection ³⁶	12.95	TP53 MYC CCND1 BCL2 BAX ATM
4	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²² Thyroid cancer ³⁶	12.89	TP53 PTPN11 MYC CCND1 BCL2 BAX
5	Pathways in cancer ³⁶	12.86	TP53 MYC CCND1 BCL2 BAX ALK
6	Measles ³⁶ Show member pathways Epstein-Barr virus infection ³⁶ Influenza A ³⁶	12.83	TP53 MYC CCND1 BCL2 BAX
7	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.77	TP53 MYC CCND1 BCL2 BAX
8	Apoptosis Modulation and Signaling ¹ Show member pathways Apoptosis ³⁶ Apoptosis ¹ Apoptosis and survival Apoptotic TNF-family pathways ²² Apoptosis Signaling Pathways ⁶⁴	12.72	TP53 MYC BCL2 BAX ATM
9	Chks in Checkpoint Regulation ⁶³ Show member pathways DNA Repair Mechanisms ⁶³ Estrogen-mediated S-Phase Entry ⁶³ G2-M Phase Transition ⁶³ Parkinson's Disease Pathway ⁶³ SREBP Proteolysis ⁶³	12.71	TP53 MYC CCND1 BCL2 BAX ATM
10	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.66	TP53 CCND1 BCL2 BAX ATM ALK
11	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶³ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.61	TP53 PTPN11 MYC BCL2 BAX
12	ErbB signaling pathway ³⁶ ¹ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ³⁶ Renal cell carcinoma ³⁶ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.58	TP53 PTPN11 MYC CCND1 BCL2 BAX
13	MicroRNAs in cancer ³⁶	12.56	TP53 MYC CCND1 BCL2 ATM
14	Prolactin Signaling Pathway ³⁶ ¹ Show member pathways Development Prolactin receptor signaling ²² Leptin signaling pathway ¹	12.5

Lymphoma

Aliases & Classifications for Lymphoma

MalaCards integrated aliases for Lymphoma:

Classifications:

External Ids:

Summaries for Lymphoma

Related Diseases for Lymphoma

Diseases in the Lymphoma family:

Diseases related to Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Lymphoma:

Symptoms & Phenotypes for Lymphoma

GenomeRNAi Phenotypes related to Lymphoma according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Lymphoma:

Drugs & Therapeutics for Lymphoma

Drugs for Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Cochrane evidence based reviews: lymphoma

Genetic Tests for Lymphoma

Genetic tests related to Lymphoma:

Anatomical Context for Lymphoma

MalaCards organs/tissues related to Lymphoma:

Publications for Lymphoma

Articles related to Lymphoma:

Genes for Lymphoma

Genes related to Lymphoma (3 elite genes):

Variations for Lymphoma

ClinVar genetic disease variations for Lymphoma:

Cosmic variations for Lymphoma:

Copy number variations for Lymphoma from CNVD:

Expression for Lymphoma

Pathways for Lymphoma

Pathways related to Lymphoma according to GeneCards Suite gene sharing:

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :