Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: LYM118
MIFTS: 68

Lymphoma

Categories: Blood diseases, Cancer diseases, Eye diseases, Immune diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Lymphoma

About this section

MalaCards integrated aliases for Lymphoma:

Name: Lymphoma 12 74 58 29 54 6 42 43 15 17 71
Lymphoid Neoplasm 71
Lymphoid Cancers 71
Lymphoid Cancer 12
Lymphomas 15

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Blood diseases Eye diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 32
Orphanet: 58  
Rare haematological diseases


External Ids:

Disease Ontology 12 DOID:0060058
MeSH 43 D008223
NCIt 49 C3208 C7065
SNOMED-CT 67 21964009
ICD10 32 C85.9
MESH via Orphanet 44 D008223
UMLS via Orphanet 72 C0024299
Orphanet 58 ORPHA223735
UMLS 71 C0024299 C0598798 C0746336
Sources

Summaries for Lymphoma

About this section
MedlinePlus : 42 Lymphoma is a cancer of a part of the immune system called the lymph system. There are many types of lymphoma. One type is Hodgkin disease. The rest are called non-Hodgkin lymphomas. Non-Hodgkin lymphomas begin when a type of white blood cell, called a T cell or B cell, becomes abnormal. The cell divides again and again, making more and more abnormal cells. These abnormal cells can spread to almost any other part of the body. Most of the time, doctors don't know why a person gets non-Hodgkin lymphoma. You are at increased risk if you have a weakened immune system or have certain types of infections. Non-Hodgkin lymphoma can cause many symptoms, such as Swollen, painless lymph nodes in the neck, armpits or groin Unexplained weight loss Fever Soaking night sweats Coughing, trouble breathing or chest pain Weakness and tiredness that don't go away Pain, swelling or a feeling of fullness in the abdomen Your doctor will diagnose lymphoma with a physical exam, blood tests, a chest x-ray, and a biopsy. Treatments include chemotherapy, radiation therapy, targeted therapy, biological therapy, or therapy to remove proteins from the blood. Targeted therapy uses drugs or other substances that attack specific cancer cells with less harm to normal cells. Biologic therapy boosts your body's own ability to fight cancer. If you don't have symptoms, you may not need treatment right away. This is called watchful waiting. NIH: National Cancer Institute

MalaCards based summary : Lymphoma, also known as lymphoid neoplasm, is related to lymphoma, non-hodgkin, familial and lymphoma, mucosa-associated lymphoid type. An important gene associated with Lymphoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are IL-2 Pathway and PI3K-Akt signaling pathway. The drugs Ferrous succinate and Tropisetron have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs.

Wikipedia : 74 Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell). The... more...

Sources

Related Diseases for Lymphoma

About this section

Diseases in the Lymphoma family:

Adult Lymphoma Eye Lymphoma

Diseases related to Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2884)
# Related Disease Score Top Affiliating Genes
1 lymphoma, non-hodgkin, familial 36.1 TP53 TCL1A MYC MALT1 CXCR5 CCND1
2 lymphoma, mucosa-associated lymphoid type 36.0 TP53 MYC MALT1 CXCR5 CCND1 BCL6
3 follicular lymphoma 35.9 MYC CXCR5 CCND1 BCL6 BCL2 BCL10
4 burkitt lymphoma 35.9 TP53 TCL1A PVT1 PMS2 MYC CXCR5
5 diffuse large b-cell lymphoma 35.9 TP53 TCL1A MYC MALT1 CCND1 BCL6
6 peripheral t-cell lymphoma 35.7 TP53 TCL1A CCND1 BCL6 ATM ALK
7 lymphoma, hodgkin, classic 35.7 PVT1 BCL6 BCL2 ALK
8 primary central nervous system lymphoma 35.6 CXCR5 BCL6 BCL2
9 gastric lymphoma 35.5 TP53 MALT1 CXCR5 BCL6 BCL10
10 intraocular lymphoma 35.5 CXCR5 BCL6 BCL2
11 lymphoma aids related 35.4 TCL1A MYC BCL6
12 marginal zone b-cell lymphoma 35.4 MALT1 CCND1 BCL6 BCL2 BCL10
13 follicular lymphoma 1 35.3 BCL6 BCL2 BCL10
14 central nervous system lymphoma 35.3 TP53 MYC MALT1 CXCR5 BCL6
15 b-cell lymphoma 35.3 TP53 TCL1A PVT1 MYC MALT1 GAS5
16 lymphoblastic lymphoma 35.2 TP53 MYC BCL6
17 mantle cell lymphoma 35.2 TP53 TCL1A MYC MALT1 GAS5 CCND1
18 primary mediastinal b-cell lymphoma 35.2 TCL1A BCL6 BCL2
19 nodular lymphocyte predominant hodgkin lymphoma 35.1 CCND1 BCL6
20 alk-negative anaplastic large cell lymphoma 35.1 MYC BCL2 BAX ALK
21 plasmablastic lymphoma 35.0 MYC BCL6
22 nodal marginal zone b-cell lymphoma 34.9 MALT1 BCL6 BCL2
23 primary mediastinal large b-cell lymphoma 34.8 BCL6 BCL2
24 b-cell non-hodgkin lymphoma 34.8 BCL7A BCL6 ATM
25 pediatric lymphoma 34.8 TCL1A MYC BCL6 ALK
26 primary cutaneous marginal zone b-cell lymphoma 34.8 MALT1 BCL10
27 gastrointestinal lymphoma 34.7 MALT1 CCND1 BCL6
28 reticulosarcoma 34.7 MYC BCL6 BCL2 ALK
29 adult lymphoma 34.7 MYC BCL6 ALK
30 diffuse large b-cell lymphoma of the central nervous system 34.7 MYC BCL2
31 acute t cell leukemia 34.7 TP53 TCL6 MYC BCL10 BAX
32 eye lymphoma 34.7 CXCR5 BCL6
33 intravascular large b-cell lymphoma 34.7 BCL6 BCL2
34 orbit lymphoma 34.7 MALT1 BCL10
35 primary cutaneous cd4+ small/medium-sized pleomorphic t-cell lymphoma 34.7 CXCR5 BCL6
36 lung lymphoma 34.6 MALT1 BCL6
37 breast lymphoma 34.6 BCL6 ALK
38 heart lymphoma 34.6 BCL6 ALK
39 leukemia, acute lymphoblastic 34.4 PTPN11 PMS2 BCL6 BCL2 BAX ATM
40 high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement 34.4 MYC BCL6 BCL2
41 precursor t-cell acute lymphoblastic leukemia 33.9 TCL1A MYC BCL10 BAX
42 richter's syndrome 33.9 TP53 MYC ATM
43 cll/sll 33.8 TP53 CCND1 BCL6 ATM
44 leukemia, chronic lymphocytic 33.7 TP53 TCL1A PTPN11 MYC DLEU2 CXCR5
45 gastric adenocarcinoma 33.6 TP53 MYC CCND1 BCL2 BAX ATM
46 monoclonal gammopathy of uncertain significance 33.4 TP53 MYC CCND1
47 human herpesvirus 8 33.0 BCL6 BCL2
48 acquired immunodeficiency syndrome 32.8 TP53 MYC CXCR5 CCND1 BCL6
49 lymphocytic leukemia 32.6 TP53 PTPN11 MYC DLEU2 CCND1 BCL2
50 adenocarcinoma 32.5 TP53 MYC CCND1 BCL2 BAX ALK

Graphical network of the top 20 diseases related to Lymphoma:



Diseases related to Lymphoma
Sources

Symptoms & Phenotypes for Lymphoma

About this section

GenomeRNAi Phenotypes related to Lymphoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.47 ATM BAX BCL10 BCL2 MALT1 TP53
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.47 ATM BAX BCL10 BCL2 CCND1 MALT1

MGI Mouse Phenotypes related to Lymphoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.17 ATM BAX BCL10 BCL2 BCL6 CCND1
2 hematopoietic system MP:0005397 10.15 ATM BAX BCL10 BCL2 BCL6 CCND1
3 endocrine/exocrine gland MP:0005379 10.14 ALK ATM BAX BCL10 BCL2 BCL6
4 immune system MP:0005387 10.1 ATM BAX BCL10 BCL2 BCL6 CCND1
5 mortality/aging MP:0010768 10.07 ALK ATM BAX BCL10 BCL2 BCL6
6 neoplasm MP:0002006 9.81 ALK ATM BAX BCL2 CCND1 MYC
7 reproductive system MP:0005389 9.36 ALK ATM BAX BCL2 BCL6 CCND1
8 pigmentation MP:0001186 9.35 ALK BCL2 MYC PTPN11 TP53
Sources

Drugs & Therapeutics for Lymphoma

About this section

Drugs for Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 899)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ferrous succinate Approved Phase 4 10030-90-7
2
Tropisetron Approved, Investigational Phase 4 105826-92-4, 89565-68-4 5595
3
Palonosetron Approved, Investigational Phase 4 135729-61-2, 135729-56-5, 119904-90-4 148211
4
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
5
Everolimus Approved Phase 4 159351-69-6 6442177 70789204
6
Nitric Oxide Approved Phase 4 10102-43-9 145068
7
Sodium citrate Approved, Investigational Phase 4 68-04-2
8
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
9
Adalimumab Approved Phase 4 331731-18-1 16219006
10
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
11
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
12
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
13
Nitazoxanide Approved, Investigational, Vet_approved Phase 4 55981-09-4 41684
14
Protein C Approved Phase 4
15
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
16
Posaconazole Approved, Investigational, Vet_approved Phase 4 171228-49-2 147912
17
Micafungin Approved, Investigational Phase 4 235114-32-6 3081921 477468
18
Tobramycin Approved, Investigational Phase 4 32986-56-4 5496 36294
19
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
20
Potassium citrate Approved, Investigational, Vet_approved Phase 4
21
Lithium carbonate Approved Phase 4 554-13-2
22
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
23
Morphine Approved, Investigational Phase 4 57-27-2 5288826
24
Epirubicin Approved Phase 4 56420-45-2 41867
25
Nicotine Approved Phase 4 54-11-5 942 89594