MCID: LYM118
MIFTS: 69

Lymphoma

Categories: Blood diseases, Cancer diseases, Eye diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Lymphoma

MalaCards integrated aliases for Lymphoma:

Name: Lymphoma 12 73 58 29 54 6 42 44 15 17 70
Lymphoid Neoplasm 70
Lymphoid Cancers 70
Lymphoid Cancer 12
Lymphomas 15

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

Disease Ontology 12 DOID:0060058
MeSH 44 D008223
NCIt 50 C3208 C7065
SNOMED-CT 67 118600007 414628006
ICD10 32 C85.9
MESH via Orphanet 45 D008223
UMLS via Orphanet 71 C0024299
Orphanet 58 ORPHA223735
UMLS 70 C0024299 C0598798 C0746336

Summaries for Lymphoma

MedlinePlus : 42 Lymphoma is a cancer of a part of the immune system called the lymph system. There are many types of lymphoma. One type is Hodgkin disease. The rest are called non-Hodgkin lymphomas. Non-Hodgkin lymphomas begin when a type of white blood cell, called a T cell or B cell, becomes abnormal. The cell divides again and again, making more and more abnormal cells. These abnormal cells can spread to almost any other part of the body. Most of the time, doctors don't know why a person gets non-Hodgkin lymphoma. You are at increased risk if you have a weakened immune system or have certain types of infections. Non-Hodgkin lymphoma can cause many symptoms, such as Swollen, painless lymph nodes in the neck, armpits or groin Unexplained weight loss Fever Soaking night sweats Coughing, trouble breathing or chest pain Weakness and tiredness that don't go away Pain, swelling or a feeling of fullness in the abdomen Your doctor will diagnose lymphoma with a physical exam, blood tests, a chest x-ray, and a biopsy. Treatments include chemotherapy, radiation therapy, targeted therapy, biological therapy, or therapy to remove proteins from the blood. Targeted therapy uses drugs or other substances that attack specific cancer cells with less harm to normal cells. Biologic therapy boosts your body's own ability to fight cancer. If you don't have symptoms, you may not need treatment right away. This is called watchful waiting. NIH: National Cancer Institute

MalaCards based summary : Lymphoma, also known as lymphoid neoplasm, is related to lymphoma, non-hodgkin, familial and diffuse large b-cell lymphoma. An important gene associated with Lymphoma is PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11), and among its related pathways/superpathways are Cytokine Signaling in Immune system and IL-2 Pathway. The drugs Entecavir and Idarubicin have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and breast, and related phenotypes are cellular and endocrine/exocrine gland

Disease Ontology : 12 A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs.

Wikipedia : 73 T-lymphoblastic leukemia/lymphoma (WHO 2008), previously labeled precursor T-lymphoblastic... more...

Related Diseases for Lymphoma

Diseases in the Lymphoma family:

Adult Lymphoma Eye Lymphoma

Diseases related to Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2958)
# Related Disease Score Top Affiliating Genes
1 lymphoma, non-hodgkin, familial 34.0 TP53 TCL1A MYD88 MYC MALT1 EZH2
2 diffuse large b-cell lymphoma 33.9 TP53 MYD88 MYC MALT1 EZH2 CCND1
3 lymphoma, hodgkin, classic 33.9 PVT1 BCL6 BCL2 ALK
4 lymphoma, mucosa-associated lymphoid type 33.8 TP53 MYD88 MYC MALT1 CXCR5 CCND1
5 follicular lymphoma 33.8 MYC EZH2 CXCR5 CCND1 BCL6 BCL2
6 burkitt lymphoma 33.7 TP53 TCL1A PVT1 PMS2 MYC CXCR5
7 primary central nervous system lymphoma 33.6 MYD88 CXCR5 BCL6 BCL2
8 peripheral t-cell lymphoma 33.5 TP53 TCL1A CCND1 BCL6 ALK
9 b-cell lymphoma 33.5 TP53 TCL1A PVT1 MYD88 MYC MALT1
10 marginal zone b-cell lymphoma 33.5 MYD88 MALT1 CCND1 BCL6 BCL2 BCL10
11 gastric lymphoma 33.4 TP53 MALT1 CXCR5 BCL6 BCL10
12 intraocular lymphoma 33.4 CXCR5 BCL6 BCL2
13 central nervous system lymphoma 33.4 TP53 MYD88 MYC MALT1 CXCR5 BCL6
14 lymphoma aids related 33.3 TCL1A MYC BCL6
15 lymphoblastic lymphoma 33.2 TP53 MYC BCL6
16 mature t-cell and nk-cell lymphoma 33.2 TP53 MYC BCL6 ALK
17 reticulosarcoma 33.2 MYC BCL6 BCL2 ALK
18 leukemia, acute lymphoblastic 33.2 TP53 TCL1A PTPN11 MYC CXCR5 BCL6
19 sezary's disease 33.2 TP53 MYC BCL6 BCL10 ALK
20 splenic marginal zone lymphoma 33.2 MALT1 EZH2 BCL6
21 follicular lymphoma 1 33.1 BCL6 BCL2
22 t-cell acute lymphoblastic leukemia 33.1 TP53 TCL6 MYC EZH2 BCL10
23 nodular lymphocyte predominant hodgkin lymphoma 33.0 CCND1 BCL6
24 primary mediastinal b-cell lymphoma 33.0 TCL1A BCL6 BCL2
25 plasmablastic lymphoma 33.0 MYC BCL6
26 alk-negative anaplastic large cell lymphoma 32.9 MYC BCL2 ALK
27 bone lymphoma 32.9 BCL6 ALK
28 mantle cell lymphoma 32.9 TP53 TCL1A MYC MALT1 GAS5 EZH2
29 intravascular large b-cell lymphoma 32.8 MYD88 MYC BCL6 BCL2
30 lung lymphoma 32.8 MALT1 BCL6
31 b-lymphoblastic leukemia/lymphoma 32.8 PTPN11 MYC CXCR5 ALK
32 b-cell non-hodgkin lymphoma 32.8 BCL7A BCL6
33 gastrointestinal lymphoma 32.8 MALT1 CCND1 BCL6
34 breast lymphoma 32.8 BCL6 ALK
35 orbit lymphoma 32.8 MALT1 BCL10
36 pediatric lymphoma 32.7 TCL1A MYC BCL6 ALK
37 cll/sll 32.7 TP53 EZH2 CCND1 BCL6
38 gallbladder lymphoma 32.7 MALT1 CCND1 BCL6
39 lymphosarcoma 32.7 BCL6 BCL2
40 nodal marginal zone b-cell lymphoma 32.7 MALT1 BCL6 BCL2
41 adult lymphoma 32.7 MYC BCL6 ALK
42 paranasal sinus lymphoma 32.6 MYC BCL6
43 retina lymphoma 32.6 CXCR5 BCL10
44 eye lymphoma 32.6 CXCR5 BCL6
45 leukemia, chronic lymphocytic 32.6 TP53 TCL1A PTPN11 MYD88 MYC DLEU2
46 primary cutaneous marginal zone b-cell lymphoma 32.6 MALT1 BCL10
47 heart lymphoma 32.5 BCL6 ALK
48 primary cutaneous diffuse large b-cell lymphoma, leg type 32.5 MYD88 MYC
49 appendix lymphoma 32.5 MYC BCL6
50 t-cell lymphoblastic leukemia/lymphoma 32.5 TCL1A MYC GAS5 CCND1 BCL2

Graphical network of the top 20 diseases related to Lymphoma:



Diseases related to Lymphoma

Symptoms & Phenotypes for Lymphoma

MGI Mouse Phenotypes related to Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.14 BCL10 BCL2 BCL6 CCND1 CXCR5 EZH2
2 endocrine/exocrine gland MP:0005379 10.11 ALK BCL10 BCL2 BCL6 CCND1 EZH2
3 hematopoietic system MP:0005397 10.1 BCL10 BCL2 BCL6 CCND1 CXCR5 EZH2
4 immune system MP:0005387 10.03 BCL10 BCL2 BCL6 CCND1 CXCR5 EZH2
5 integument MP:0010771 9.81 ALK BCL2 BCL6 CCND1 EZH2 MALT1
6 neoplasm MP:0002006 9.61 ALK BCL2 CCND1 EZH2 MYC MYD88
7 reproductive system MP:0005389 9.32 ALK BCL2 BCL6 CCND1 MYC MYD88

Drugs & Therapeutics for Lymphoma

Drugs for Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 832)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
2
Idarubicin Approved Phase 4 58957-92-9 42890
3
Ferrous succinate Approved Phase 4 10030-90-7
4
Nicotine Approved Phase 4 54-11-5 942 89594
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
7
Cytarabine Approved, Investigational Phase 4 147-94-4 6253
8
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
9
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
10
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
11
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
12
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
13
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
14
Etoposide Approved Phase 4 33419-42-0 36462
15
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
16
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
17
Teniposide Approved Phase 4 29767-20-2 34698
18
Mercaptopurine Approved Phase 4 50-44-2 667490
19
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
20
Mitoxantrone Approved, Investigational Phase 4 65271-80-9 4212
21
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
22
Palonosetron Approved, Investigational Phase 4 119904-90-4, 135729-56-5 148211
23
Daunorubicin Approved Phase 4 20830-81-3 30323
24
Nitric Oxide Approved Phase 4 10102-43-9 145068
25
Infliximab Approved Phase 4 170277-31-3
26
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
27
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
28
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
29
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
30
Micafungin Approved, Investigational Phase 4 235114-32-6 3081921 477468
31
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
32
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
33
Cisplatin Approved Phase 4 15663-27-1 84093 441203 2767
34
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
35
Prilocaine Approved Phase 4 721-50-6 4906
36
tannic acid Approved Phase 4 1401-55-4
37
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
38
Epirubicin Approved Phase 4 56420-45-2 41867
39
Methoxsalen Approved Phase 4 298-81-7 4114
40
Sofosbuvir Approved Phase 4 1190307-88-0 45375808
41
Ledipasvir Approved Phase 4 1256388-51-8 67505836
42
Zidovudine Approved Phase 4 30516-87-1 35370
43
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
44
Ribavirin Approved Phase 4 36791-04-5 37542
45
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
46
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
47
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
48
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
49
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
50
Calcifediol Approved, Nutraceutical Phase 4 19356-17-3 5283731 6433735

Interventional clinical trials:

(show top 50) (show all 6729)
# Name Status NCT ID Phase Drugs
1 Self-control Trial to Evaluate the Role of Aprepitant in the Prophylaxis of Post-lumbar-punture-headache (PLPH) Unknown status NCT02347878 Phase 4 Aprepitant
2 Rituximab (RTX) Therapy in Steroid Resistant Patients or Patients Relapsing After Intravenous Steroids With Active TAO Unknown status NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate
3 A Multicenter Study to Compare the Efficacy of a Prophylactic Use of Tenofovir by Duration for the Non-Hodgkin's Lymphoma Patients With Isolated Anti-HBc-positivity Who Will be Treated With Rituximab Based Chemotherapy Unknown status NCT02585947 Phase 4 Tenofovir
4 Comparison of Methotrexate Versus Interferon-alfa 2b on Efficacy, Safety and Quality of Life in Patients With Primary Cutaneous T-cell Lymphomas Unknown status NCT02323659 Phase 4 Methotrexate;Interferon Alfa-2b
5 Single-arm, Multi-center Clinical Study of Crizotinib Combined With Etoposide Capsule Followed by Auto-HSCT for Relapsed and Refractory Anaplastic Lymphoma Kinase (ALK)-Positive Anaplastic Large Cell Lymphoma (ALCL) Unknown status NCT03707847 Phase 4 Crizotinib;Etoposide Capsule
6 An Open-label,Multicenter Randomised Study of CTOP/ITE/MTX Compared With CHOP as the First-line Therapy for the New Diagnosed Young Patients With T Cell Non-hodgkin Lymphoma Unknown status NCT01746992 Phase 4 Cyclophosphamide 750mg/m2;Vincristine 1.4mg/m2;Doxorubicin 50mg/m2;prednisone 60mg/m2;ifosfamide 2000mg/m2;pirarubicin 50mg/m2;pirarubicin 25mg/m2;Etoposide phosphate 100mg/m2;methotrexate 1500mg/m2
7 A Clinical Trial of Decitabine in Relapse and Refractory Diffuse Large B Cell Lymphoma Unknown status NCT03579082 Phase 4 Decitabine
8 Treatment of Elderly Patients With Diffuse Large B-cell Lymphoma Unknown status NCT03513601 Phase 4 (R)-CHOP regimen;(R)-CVP regimen
9 A Clinical Trial of Decitabine Combined With CODOX-M/IVAC in Relapsed or Refractory T-lymphoblastic Lymphoma Unknown status NCT03558412 Phase 4 Decitabine
10 A Multi-Center, Open-Labelled, Pralatrexate Study in Asian Patients With Peripheral T-cell Lymphoma After Prior Therapy Unknown status NCT03150602 Phase 4 Pralatrexate
11 A Randomized Controlled Clinical Trial of Apatinib Combined With CHOP Regimen in the Treatment of Newly Diagnosed Peripheral T-cell Lymphoma Unknown status NCT03631862 Phase 4 Apatinib;CHOP Regimen
12 A Randomized, Controlled Mutiple-center Clinical Research on the Treatment With Yangzhengxiaoji Capsule Combination Chemotherapy for III/IV Diffuse Large B Cell Lymphoma Unknown status NCT01949818 Phase 4 Yangzhengxiaoji capsule combined with CHOP regimen;CHOP regimen
13 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
14 Clinical Application of Polyethylene Glycol Liposome Doxorubicin (PLD) in Primary Lymphoma Unknown status NCT02526823 Phase 4 R-CHOP/CHOPE or ABVD chemotherapy regimen;R-CDOP/CDOPE or DBVD chemotherapy regimen
15 EDOCH Alternating With DHAP Regimen Combined Rituximab or Not to Treat New Diagnosed Younger (Age≤65 Years) Mantle Cell Lymphoma in China: A Multicentre Phase III Trial Unknown status NCT02858804 Phase 4 Etoposide;Doxorubicin;Dexamethasone;Vincristine;Cyclophosphamide;Cytarabine;Cisplatin;Rituximab;Thalidomide;Prednisone
16 A Randomized Controlled Multi-center Clinical Trial on Treatment of Stage Ⅲ/Ⅳ NK/T Cell Lymphoma With DDGP Regiment (Gemcitabine,Pegaspargase,Cisplatin,Dexamethasone) Unknown status NCT01501149 Phase 4 DDGP(cisplatin,dexamethasone,gemcitabine,pegaspargase);Modified SMILE (MTX,DEX,IFO,L-ASP,Etoposide,Mesna)
17 PEG-rhG-CSF in Patients With Non-Hodgkin Lymphoma Receiving Chemotherapy to Prevent Neutropenia Unknown status NCT02996617 Phase 4 rhG-CSF regimen;Pegylated rhG-CSF regimen
18 A Randomized Controlled Multi-center Clinical Trial on Treatment of Stage I/II NK/T Cell Lymphoma With DDGP Regiment (Gemcitabine,Pegaspargase,Cisplatin,Dexamethasone) Unknown status NCT01501136 Phase 4
19 The Prospective Study of FVD Program and HD-MTX-Ara-C Program Contrast in the Treatment of PCNSL Lymphoma. Unknown status NCT01960192 Phase 4 HD-MTX-Ara-C regimen;FVD regimen
20 A Single Center Randomized Controlled Trial of the Efficacy and Safety of PEG-rhG-CSF After Autologous Hematopoietic Stem Cell Transplantation for Lymphoma Patients Unknown status NCT02905942 Phase 4 PEG-rhG-CSF;rhG-CSF
21 Study of Standard and Individualized Treatment Model for Relapse and Refractory Lymphatic System Malignant Tumors Unknown status NCT02929615 Phase 4
22 Optimization of the Primary Therapy for Patients With Hodgkin's Lymphoma and Evaluation of the Positron Emission Tomography (PET) as a Diagnostic Tool for Primary Staging and Assessment of the Effects of the Therapy Unknown status NCT00188149 Phase 4 Combined chemotherapy (ABVD, BACOPP-D)
23 Prophylactic Use of Entecavir for HBsAg Negative/HBcAb Positive/Hepatitis B Virus DNA Negative Patients With Lymphoma Unknown status NCT01765231 Phase 4 Entecavir prophylaxis;Observation arm
24 Prophylactic Use of Entecavir for HBsAg Positive Lymphoma Patients Treated With Rituximab-based Immunochemotherapy Unknown status NCT01768195 Phase 4 Entecavir prophylaxis
25 Efficacy and Safety of Erythropoietin in the Treatment of Anemia in Patients With Lymphoma After Autologous Hematopoietic Stem Cell Transplantation Unknown status NCT03010579 Phase 4 erythropoietin;iron supplementation
26 Multicenter Study To Optimize Treatment in Elderly Patients (> 55 Years, No Upper Age Limit) With Acute Lymphoblastic Leukemia (GMALL Elderly 1/2003)(Amend 2) Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
27 An Open-label,Multi-center,Prospective Study of Idarubicin and Etoposide Intensified Conditioning Regimen Allogeneic Hematopoietic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
28 PEG-asparaginase During Two Treatment Courses in the Treatment of Childhood Acute Lymphoblastic Leukemia Unknown status NCT00192673 Phase 4 PEG-asparaginase
29 Plasma Kinetics of Tablet and Liquid Formulations of 6-mercaptopurine in Childhood Acute Lymphoblastic Leukemia. Unknown status NCT01906671 Phase 4 Xaluprine;Puri-Nethol
30 Medical Research Council Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
31 German Multicenter Study for Treatment Optimisation in Acute Lymphoblastic Leukemia in Adults and Adolescents Above 15 Years (Amend 3) (GMALL 07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
32 G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor: a Prospective, Multicentre, Randomised Controlled Trial Unknown status NCT02933333 Phase 4
33 Clinical Study of GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia in Guangdong Province Unknown status NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
34 Ma-Spore ALL 2010 Study Unknown status NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
35 The Combination of Lower Dosage of Chemotherapy With Tyrosine Kinase Inhibitor to Treat Newly Diagnosed ph+ Acute Lymphoblastic Leukemia Patients Unknown status NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
36 Philadelphia -Negative High-risk Children Acute Lymphoblastic Leukemia(ALL) Treatment:Induction Therapy:Vincristine(V),Idarubicin(I),L-asparaginase(L),Dexamethasone(D);Consolidation:V+Daunorubicin(D)+L+D, Methotrexate,Cytarabine Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
37 Prophylactic Use of Entecavir for Chemotherapy Associated With Hepatitis B Reactivation in HBsAg (-), Anti-HBc (+) Non-Hodgkin's Lymphoma Patients: a Randomized Controlled Trial Completed NCT00926757 Phase 4 Entecavir prophylaxis;Therapeutic entecavir
38 AMENO-2: Fase IV Study, National, Multiple Centers, Competitive, Randomized, Double Blind, Controlled With Parallel Groups to Determinate the Security, Tolerability and Efficacy of Aprepitant Plus Palonosetron Versus Granisetron in the Prevention of Nausea and the Emesis Induced by Chemotherapy in Patients Treated With Haematopoietic Progenitors Completed NCT00415103 Phase 4 Aprepitant;Palonosetron;Granisetron
39 Assisted Oocyte Activation (AOA) in Recurrent Fertilization Failure Completed NCT04744753 Phase 4 Calcium Ionophore A23187
40 Apatinib for Relapsed and Refractory Difuse Large B Cell Lymphoma: an Open-label, Single Armed, Exploratory Study Completed NCT03376958 Phase 4 Apatinib
41 Multicenter Study to Optimise Therapy of B-ALL, Burkitt's NHL and High-Grade Non-Hodgkin's Lymphoma in Adults (Amend 7) Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
42 UVADEX Sterile Solution in Conjunction With the UVAR XTS Photopheresis System as an Interventional Therapy for the Treatment Of CTCL (Mycosis Fungoides) in Patients With TMN Classification Stage 1A, 1B, 2A Completed NCT00221039 Phase 4 Methoxsalen+ECP
43 Open Label Study of ONTAK® (Denileukin Diftitox, DAB389IL-2) to Estimate Response in Cutaneous T-Cell Lymphoma (CTCL) According to CD25 Status Completed NCT00211198 Phase 4 ONTAK (denileukin difitox, DAB389IL-2)
44 A Multicenter Open-Label Study to Evaluate the Safety and Efficacy of DAB389IL-2 in Cutaneous T-Cell Lymphoma (CTCL) Patients Following Protocol 93-04-10, Protocol 93-04-11, or Protocol 92-04-01 or Who Meet the Requirements for Protocol 93-04-11 Except Have Biopsy-Documented CTCL That Does Not Express CD25 Completed NCT00051012 Phase 4 ONTAK
45 A Multicenter Phase III Randomized Double-Blind Placebo-Controlled Study to Evaluate the Efficacy of Two Dose Levels of DAB389IL-2 (9 and 18 Mcg/kg/Day) in Cutaneous T-Cell Lymphoma (CTCL) Patients With Stage Ia-III Disease Who, Following Less Than or Equal to 3 Previous Therapies, Have Recurrent or Persistent Disease That Has Been Biopsy-Documented to Express CD25 Completed NCT00050999 Phase 4 ONTAK
46 A RANDOMIZED PHASE 4 STUDY COMPARING 2 INTRAVENOUS TEMSIROLIMUS (TEMSR) REGIMENS IN SUBJECTS WITH RELAPSED, REFRACTORY MANTLE CELL LYMPHOMA Completed NCT01180049 Phase 4 temsirolimus;temsirolimus
47 Phase IV Randomized Study of Two Dose Levels of Targretin® Capsules in Subjects With Refractory Cutaneous T-Cell Lymphoma Completed NCT01007448 Phase 4 Bexarotene
48 A Randomized Controlled Multi-center Clinical Trial on Treatment of Peripheral T-cell Lymphoma With DGPT Regiment (Gemcitabine,Cisplatin,Prednisone ,Thalidomide ) Completed NCT01664975 Phase 4 GDPT regimen;CHOP regimen
49 LINFOTARGAM: First-line Treatment With Dose-dense Chemotherapy Plus Rituximab (R-CHOP/14) and Highly Active Antiretroviral Therapy (HAART) in Patients With Diffuse Large B Cell Lymphoma (DLBCL) and Infection With the Human Immunodeficiency Virus (HIV) Completed NCT00466258 Phase 4 R-CHOP;Highly active antiretroviral therapy;Central nervous system (CNS) prophylaxis;Prophylaxis of opportunistic infections and support treatment
50 Estimation of Carbohydrate Metabolism Disorder Frequency in Hypertriglyceridemia Induced by Bexarotene Treatment of Cutaneous T Cell Lymphoma - Pilote Study Completed NCT01569724 Phase 4

Search NIH Clinical Center for Lymphoma

Inferred drug relations via UMLS 70 / NDF-RT 51 :


ASPARAGINASE
Cytarabine
Cytarabine liposome
irinotecan
Irinotecan hydrochloride
Mitoxantrone
Mitoxantrone Hydrochloride
Thiotepa

Cochrane evidence based reviews: lymphoma

Genetic Tests for Lymphoma

Genetic tests related to Lymphoma:

# Genetic test Affiliating Genes
1 Lymphoma 29

Anatomical Context for Lymphoma

MalaCards organs/tissues related to Lymphoma:

40
T Cells, Bone Marrow, Breast, Bone, Myeloid, Skin, B Cells

Publications for Lymphoma

Articles related to Lymphoma:

(show top 50) (show all 57588)
# Title Authors PMID Year
1
Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma. 6 61
24563539 2014
2
Oncogenically active MYD88 mutations in human lymphoma. 6 61
21179087 2011
3
Clinical prognosis and bioinformatic analysis of primary thyroid lymphoma. 61 42
33578562 2021
4
A comparative study of multimodal magnetic resonance in the differential diagnosis of acquired immune deficiency syndrome related primary central nervous system lymphoma and infection. 61 42
33568094 2021
5
Assessment of naive indolent lymphoma using whole-body diffusion-weighted imaging and T2-weighted MRI: results of a prospective study in 30 patients. 42 61
33413685 2021
6
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. 6
23023262 2012
7
Oncogenic activation of NF-kappaB. 54 61
20516126 2010
8
Common misdiagnoses in lymphomas and avoidance strategies. 61 54
20227918 2010
9
Loss of p73 promotes dissemination of Myc-induced B cell lymphomas in mice. 54 61
20484818 2010
10
Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas. 54 61
20299510 2010
11
Natural killer-cell receptor polymorphisms and posttransplantation non-Hodgkin lymphoma. 54 61
20207982 2010
12
C/EBPβ expression in ALK-positive anaplastic large cell lymphomas is required for cell proliferation and is induced by the STAT3 signaling pathway. 54 61
20015877 2010
13
Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1. 61 54
20197552 2010
14
IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice. 61 54
20190192 2010
15
microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma. 54 61
20086245 2010
16
Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma. 61 54
20185581 2010
17
Adult T-cell leukemia/lymphoma development in HTLV-1-infected humanized SCID mice. 54 61
20124219 2010
18
Rac1 targeting suppresses p53 deficiency-mediated lymphomagenesis. 61 54
20179179 2010
19
An uncommon case of de novo CD10+ CD5- mantle cell lymphoma mimics follicle center B cell lymphoma. 54 61
20490333 2010
20
Characterization of D-cyclin proteins in hematolymphoid neoplasms: lack of specificity of cyclin-D2 and D3 expression in lymphoma subtypes. 54 61
20062012 2010
21
Anaplastic lymphoma kinase as a therapeutic target in anaplastic large cell lymphoma, non-small cell lung cancer and neuroblastoma. 61 54
20406193 2010
22
C-C chemokine receptor 1 expression in human hematolymphoid neoplasia. 54 61
20154287 2010
23
Sodium valproate in combination with ganciclovir induces lysis of EBV-infected lymphoma cells without impairing EBV-specific T-cell immunity. 54 61
19196381 2010
24
CD81 protein is expressed at high levels in normal germinal center B cells and in subtypes of human lymphomas. 61 54
20004001 2010
25
Determining the expression rate of the IgM and IgA in B cell lymphomas by immunohistochemistry. 61 54
20437688 2010
26
PD-1 expression in T-cell lymphomas and reactive lymphoid entities: potential overlap in staining patterns between lymphoma and viral lymphadenitis. 61 54
20087161 2010
27
A recombinant adenovirus type 35 fiber knob protein sensitizes lymphoma cells to rituximab therapy. 54 61
19965652 2010
28
B-cell CLL/lymphoma 10 (BCL10) is required for NF-kappaB production by both canonical and noncanonical pathways and for NF-kappaB-inducing kinase (NIK) phosphorylation. 61 54
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Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. 61 54
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Expression profiling of transcription factors in B- or T-acute lymphoblastic leukemia/lymphoma and burkitt lymphoma: usefulness of PAX5 immunostaining as pan-Pre-B-cell marker. 54 61
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Lymphoma cells contribute to the augmentation of plasma sL-selectins in the serum of lymphoma-bearing mice. 54 61
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Nodal diffuse large B-cell lymphomas in children and adolescents: immunohistochemical expression patterns and c-MYC translocation in relation to clinical outcome. 54 61
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A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas. 54 61
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Expression of Grb2 distinguishes classical Hodgkin lymphomas from primary mediastinal B-cell lymphomas and other diffuse large B-cell lymphomas. 61 54
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Three clinical-stage tumor targeting antibodies reveal differential expression of oncofetal fibronectin and tenascin-C isoforms in human lymphoma. 54 61
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Anaplastic large cell lymphoma: one or more entities among T-cell lymphoma? 61 54
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Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling. 54 61
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Anomalous constitutive Src kinase activity promotes B lymphoma survival and growth. 61 54
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To the genesis of Burkitt lymphoma: regulation of apoptosis by EBNA-1 and SAP may determine the fate of Ig-myc translocation carrying B lymphocytes. 54 61
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Temsirolimus in mantle cell lymphoma and other non-Hodgkin lymphoma subtypes. 54 61
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[Immunohistochemical study using T-cell lymphoma antibody 1 and CD44 in diagnosis of Burkitt's lymphoma]. 61 54
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Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma. 61 54
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Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of t(14;18)-negative follicular lymphoma. 54 61
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Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma. 54 61
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Differential diagnosis of cyclin D2+ mantle cell lymphoma based on fluorescence in situ hybridization and quantitative real-time-PCR. 54 61
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The mechanisms underlying MMR deficiency in immunodeficiency-related non-Hodgkin lymphomas are different from those in other sporadic microsatellite instable neoplasms. 54 61
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Targeted deletion of p73 in mice reveals its role in T cell development and lymphomagenesis. 61 54
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SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype. 54 61
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Multiple isoforms of PAX5 are expressed in both lymphomas and normal B-cells. 54 61
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AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. 61 54
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