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NHL
MCID: LYM143
MIFTS: 73

Lymphoma, Non-Hodgkin, Familial (NHL)

Categories: Blood diseases, Cancer diseases, Genetic diseases, Immune diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Lymphoma, Non-Hodgkin, Familial

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MalaCards integrated aliases for Lymphoma, Non-Hodgkin, Familial:

Name: Lymphoma, Non-Hodgkin, Familial 58 39 41
Non-Hodgkin Lymphoma 58 39 12 77 30 6 15
Lymphoma, Non-Hodgkin 58 13 45 74
Nhl 58 76
Lymphoma, Non-Hodgkin, Somatic 58
Lymphoma, Follicular, Somatic 58
Familial Non-Hodgkin Lymphoma 76
Non-Hodgkin Lymphoma; Nhl 58
Lymphoma Non-Hodgkins 56
Non-Hodgkins Lymphoma 17

Classifications:

MalaCards categories:
Global: Genetic diseases Cancer diseases
Anatomical: Blood diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:0060060
OMIM 58 605027
MeSH 45 D008228
ICD10 34 C85.7
MedGen 43 C0024305
UMLS 74 C0024305
Sources

Summaries for Lymphoma, Non-Hodgkin, Familial

About this section
UniProtKB/Swiss-Prot : 76 Familial non-Hodgkin lymphoma: Cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss.

MalaCards based summary : Lymphoma, Non-Hodgkin, Familial, also known as non-hodgkin lymphoma, is related to anaplastic large cell lymphoma and diffuse large b-cell lymphoma. An important gene associated with Lymphoma, Non-Hodgkin, Familial is CASP10 (Caspase 10), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Tenofovir and rituximab have been mentioned in the context of this disorder. Affiliated tissues include Blood and Blood, and related phenotypes are lymphoma and Reduced mammosphere formation

Disease Ontology : 12 A lymphoma that is characterized as any kind of lymphoma except Hodgkin's lymphoma.

Wikipedia : 77 Non-Hodgkin lymphoma (NHL) is a group of blood cancers that includes all types of lymphoma except... more...

Description from OMIM: 605027
Sources

Related Diseases for Lymphoma, Non-Hodgkin, Familial

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Diseases related to Lymphoma, Non-Hodgkin, Familial via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 513)
# Related Disease Score Top Affiliating Genes
1 anaplastic large cell lymphoma 34.1 ALK NPM1 PAX5 PTPRC
2 diffuse large b-cell lymphoma 33.9 BCL10 BCL6 CD5 IRF4 MYC TP53
3 lymphoma, mucosa-associated lymphoid type 33.8 BCL10 BCL6 CCND1 CD5 IRF4
4 b-cell lymphomas 33.8 BCL10 BCL6 CCND1 CD5 IRF4 MS4A1
5 follicular lymphoma 33.7 BCL10 BCL6 CCND1 IRF4 MYC
6 richter's syndrome 33.6 CD5 IRF4 MYC TP53
7 composite lymphoma 33.2 BCL6 CD5 PAX5
8 reticulosarcoma 33.1 ALK BCL6 NPM1 PAX5 PTPRC
9 plasmablastic lymphoma 33.1 BCL6 MS4A1 MYC PTPRC
10 follicular lymphoma 1 33.0 BCL10 BCL6
11 lymphoma 32.5 ALK BCL10 BCL6 CASP10 CCND1 MYC
12 lymphoma, hodgkin, classic 32.5 ALK BCL6 CD5 PAX5 PTPRC
13 leukemia, chronic lymphocytic 32.3 BCL10 BCL6 BRAF CCND1 CD5 MS4A1
14 leukemia, chronic lymphocytic 2 32.2 BRAF NRAS TP53
15 mantle cell lymphoma 32.0 BCL6 CCND1 CD5 MYC PAX5 PTPRC
16 myeloma, multiple 32.0 BRAF CCND1 IRF4 MYC NRAS PTPRC
17 primary mediastinal large b-cell lymphoma 31.9 BCL6 IRF4 MYC
18 acquired immunodeficiency syndrome 31.6 BCL6 MYC TP53
19 leukemia, acute myeloid 31.6 MYC NPM1 NRAS PTPRC TP53
20 hodgkin's lymphoma, lymphocytic-histiocytic predominance 31.6 BCL6 PTPRC
21 marginal zone b-cell lymphoma 31.5 BCL10 BCL6 CCND1 CD5 IRF4
22 adenocarcinoma 31.4 ALK BRAF CCND1 MYC PIK3CA TP53
23 hairy cell leukemia 31.4 BRAF CCND1 CD5
24 lymphocytic leukemia 31.4 CD5 MYC PAX5 TP53
25 thyroid cancer 31.3 BRAF CCND1 MYC NRAS PIK3CA TP53
26 burkitt lymphoma 31.2 BCL6 MS4A1 MYC PAX5
27 lymphoproliferative syndrome 31.2 CASP10 NRAS PRF1
28 pancreas adenocarcinoma 31.2 CCND1 MYC PIK3CA TP53
29 skin melanoma 31.1 BRAF NRAS TP53
30 lymphoblastic lymphoma 31.1 BCL6 CD5 PTPRC
31 cholangiocarcinoma 31.1 BRAF CCND1 PIK3CA TP53
32 histiocytoma 31.1 ALK PTPRC TP53
33 gastric lymphoma 31.0 BCL10 BCL6 TP53
34 cll/sll 31.0 CCND1 CD5 PAX5 TP53
35 glioblastoma 31.0 ALK BRAF CCND1 MYC NRAS PIK3CA
36 brain cancer 31.0 ALK BRAF MYC NRAS PIK3CA TP53
37 lung cancer susceptibility 3 31.0 ALK BRAF CCND1 NRAS PIK3CA TP53
38 autoimmune lymphoproliferative syndrome 31.0 CASP10 NRAS PRF1 PTPRC
39 peripheral t-cell lymphoma 31.0 ALK BCL6 CD5 MS4A1
40 autoimmune lymphoproliferative syndrome, type v 30.9 ALK BCL6 CD5
41 small cell cancer of the lung 30.9 MYC PAX5 PIK3CA TP53
42 splenic marginal zone lymphoma 30.9 BCL6 CD5 PAX5
43 lymphosarcoma 30.9 BCL6 CD5 PTPRC
44 prolymphocytic leukemia 30.8 CCND1 CD5 MYC
45 breast ductal carcinoma 30.8 CCND1 RAD54L TP53
46 primary effusion lymphoma 30.8 BCL6 IRF4 MYC
47 breast lymphoma 30.8 BCL6 CD5
48 plasma cell leukemia 30.8 CCND1 IRF4
49 nodular lymphocyte predominant hodgkin lymphoma 30.8 BCL6 PAX5
50 acute promyelocytic leukemia 30.7 MYC NPM1 NRAS PTPRC

Graphical network of the top 20 diseases related to Lymphoma, Non-Hodgkin, Familial:



Diseases related to Lymphoma, Non-Hodgkin, Familial
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Symptoms & Phenotypes for Lymphoma, Non-Hodgkin, Familial

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Human phenotypes related to Lymphoma, Non-Hodgkin, Familial:

33
# Description HPO Frequency HPO Source Accession
1 lymphoma 33 HP:0002665

Clinical features from OMIM:

605027

GenomeRNAi Phenotypes related to Lymphoma, Non-Hodgkin, Familial according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.5 BCL6 BRAF CCND1 CD5 MYC NRAS
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.36 BCL10 RAD54B RAD54L TP53
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.36 BCL10 BRAF CCND1 MYC RAD54B RAD54L

MGI Mouse Phenotypes related to Lymphoma, Non-Hodgkin, Familial:

47 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.42 BCL10 BCL6 BRAF CCND1 IRF4 MYC
2 hematopoietic system MP:0005397 10.41 BCL10 BCL6 BRAF CCND1 CD5 IRF4
3 immune system MP:0005387 10.38 BCL10 BCL6 BRAF CCND1 CD5 IRF4
4 growth/size/body region MP:0005378 10.34 ALK BCL6 BRAF CCND1 IRF4 MYC
5 homeostasis/metabolism MP:0005376 10.31 ALK BCL6 BRAF CCND1 IRF4 MYC
6 endocrine/exocrine gland MP:0005379 10.28 ALK BCL10 BCL6 BRAF CCND1 MYC
7 mortality/aging MP:0010768 10.28 ALK BCL10 BCL6 BRAF CCND1 MYC
8 integument MP:0010771 10.16 ALK BRAF CCND1 CD5 MYC NPM1
9 neoplasm MP:0002006 10.15 ALK BRAF CCND1 IRF4 MYC NPM1
10 nervous system MP:0003631 10.1 ALK BCL10 BRAF CCND1 CD5 MYC
11 liver/biliary system MP:0005370 10.03 BCL6 BRAF MYC NPM1 NRAS PRF1
12 normal MP:0002873 9.85 BCL6 BRAF CCND1 CD5 MYC NRAS
13 no phenotypic analysis MP:0003012 9.8 BCL6 CD5 MYC NRAS PIK3CA PTPRC
14 pigmentation MP:0001186 9.35 ALK BRAF MYC NRAS TP53
15 skeleton MP:0005390 9.28 ALK BRAF CCND1 MYC NRAS PAX5
Sources

Drugs & Therapeutics for Lymphoma, Non-Hodgkin, Familial

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Drugs for Lymphoma, Non-Hodgkin, Familial (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 721)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tenofovir Approved, Experimental, Investigational Phase 4,Phase 3,Phase 1,Phase 2 147127-20-6 464205
2
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 174722-31-7 10201696
3
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2068-78-2, 57-22-7 5978
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
5
Cytarabine Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 147-94-4, 65-46-3 6253
6
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
7
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
8
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 3778-73-2 3690
9
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1177-87-3
10
Gemcitabine Approved Phase 4,Phase 3,Phase 2,Phase 1 95058-81-4 60750
11
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 23214-92-8 31703
12
Epirubicin Approved Phase 4,Phase 2,Phase 3,Phase 1 56420-45-2 41867
13
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 33419-42-0 36462
14
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 43805 6857599 5310940 9887054
15
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
16
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1959-05-2, 59-05-2 126941
17
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 135968-09-1
18
Thiotepa Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 52-24-4 5453
19
Sargramostim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 123774-72-1, 83869-56-1
20
Entecavir Approved, Investigational Phase 4,Phase 2,Not Applicable 142217-69-4 153941
21
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 75607-67-9, 21679-14-1 30751
22
Vidarabine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 24356-66-9 21704 32326
23
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 143 6006
24
Vindesine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53643-48-4, 59917-39-4 40839
25
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
26
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
27
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
28
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
29
Melphalan Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 148-82-3 460612 4053
30
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53123-88-9 46835353 5284616 6436030
31
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
32
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1 159351-69-6 70789204 6442177
33
Angiotensin II Approved, Investigational Phase 4,Phase 1 11128-99-7, 68521-88-0, 4474-91-3 172198
34
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
35
Nitric Oxide Approved Phase 4 10102-43-9 145068
36
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
37
Prilocaine Approved Phase 4 721-50-6 4906
38
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
39
Mechlorethamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 51-75-2 4033
40
Ledipasvir Approved Phase 4,Phase 2 1256388-51-8 67505836
41
Sofosbuvir Approved Phase 4,Phase 2 1190307-88-0 45375808
42
Ribavirin Approved Phase 4,Phase 3,Early Phase 1 36791-04-5 37542
43
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-30-3 6037
44
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 31703
45
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2920-86-7
46
Pirarubicin Investigational Phase 4 72496-41-4
47 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
49 Anti-HIV Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
50 Anti-Retroviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 2440)
# Name Status NCT ID Phase Drugs
1 To Compare the Efficacy of a Prophylactic Use of Tenofovir by Duration for the Non-Hodgkin's Lymphoma Unknown status NCT02585947 Phase 4 Tenofovir
2 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
3 PEG-rhG-CSF in Patients With Non-Hodgkin Lymphoma Receiving Chemotherapy to Prevent Neutropenia Unknown status NCT02996617 Phase 4 rhG-CSF regimen;Pegylated rhG-CSF regimen
4 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
5 Evaluation of Approved Weight-Based Dose Compared to Fixed Dose of Plerixafor in Patients With Non-Hodgkin's Lymphoma (NHL) Weighing Less Than 70 Kilograms Completed NCT01164475 Phase 4 Granulocyte-colony stimulating factor (G-CSF);Fixed Dose Plerixafor;Weight-Based Plerixafor
6 MAXIMA Study: A Study of Maintenance Therapy With MabThera (Rituximab) in Patients With Non-Hodgkin's Lymphoma. Completed NCT00430352 Phase 4 rituximab [MabThera/Rituxan]
7 An Expanded Access Program of Pegfilgrastim (Neulastim) in Participants With Non-Hodgkin's Lymphoma (NHL) Completed NCT02782845 Phase 4 Chemotherapy;Immunochemotherapy;Pegfilgrastim
8 Doxorubicin Pharmacokinetics and Response in Non Hodgkin's Lymphoma Completed NCT00969462 Phase 4 Doxorubicin
9 Prophylactic Use of Entecavir for Non-Hodgkin's Lymphoma Patients With Resolved Hepatitis B Completed NCT00926757 Phase 4 Entecavir prophylaxis;Therapeutic entecavir
10 Efficacy Response Duration and Toxicity of Rituximab, Fludarabine, and Cyclophosphamide (RFC) as 1st Line Treatment and Rituximab (R) in Maintenance Treatment in Follicular Non Hodgkin (FNH) Lymphoma Completed NCT01124526 Phase 4 Rituximab Fludarabine Cyclophosphamide
11 Effect of Rituximab on Immunological Recall Response to Specific Antigens in the Treatment of Non-Hodgkin's Lymphoma Completed NCT00090038 Phase 4 rituximab
12 Zevalin® Followed by Rituxan® Maintenance in Previously Treated Low Grade Non-Hodgkin’s Lymphoma Completed NCT00168727 Phase 4 ibritumomab tiuxetan (Zevalin®)
13 Prevention of CHOP-induced Chronic Cardiotoxicity Completed NCT00162955 Phase 4 Valsartan
14 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
15 PROMPT - Palifermin in Reduction of Oral Mucositis in PBSC Transplantation Completed NCT00352703 Phase 4 Kepivance (Palifermin)
16 Comparison Of 2 Doses Of Temsirolimus (Torisel) In Patients With Mantle Cell Lymphoma Completed NCT01180049 Phase 4 temsirolimus;temsirolimus
17 A Study to Assess the Hematopoyetic Response of Anemic Patients With Hematologic Malignancies Treated With Erythropoietin B Terminated NCT02608060 Phase 4 Epoetin Beta
18 Evaluation of the Analgesy With Emla and/or Nitrous Oxide in Pediatric Patients for Lumbar Puncture Completed NCT00808171 Phase 4 Livopan;Livopan;EMLA
19 CTOP/ITE/MTX Compared With CHOP as the First-line Therapy for Newly Diagnosed Young Patients With T Cell Lymphoma Active, not recruiting NCT01746992 Phase 4 Cyclophosphamide 750mg/m2;Vincristine 1.4mg/m2;Doxorubicin 50mg/m2;prednisone 60mg/m2;ifosfamide 2000mg/m2;pirarubicin 50mg/m2;pirarubicin 25mg/m2;Etoposide phosphate 100mg/m2;methotrexate 1500mg/m2
20 Oral Hepatitis C Treatment for Indolent Lymphoma (OPTImaL) Study Terminated NCT02717949 Phase 4 sofosbuvir/ledipasvir;sofosbuvir;Ribavirin
21 Ledipasvir/Sofosbuvir Treatment for Hepatitis C in HCT Recipients. Withdrawn NCT03279133 Phase 4 Ledipasvir 90mg/Sofosubvir 400mg
22 A Study of Primary Prophylaxis With Neulasta (Pegfilgrastim) Versus Secondary Prophylaxis After Chemotherapy in Elderly Subjects (>/= 65 Years Old) With Cancer Completed NCT00277160 Phase 4 Neulasta (pegfilgrastim)
23 ALL-REZ BFM 2002: Multi-Center Study for Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
24 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3 ketamine hydrochloride
25 Epoetin Alfa or Epoetin Beta With or Without Iron Infusion in Treating Anemia in Patients With Cancer Unknown status NCT00482716 Phase 3
26 Early Hospital Discharge or Standard Inpatient Care in Cancer Patients Receiving Antibiotics for Febrile Neutropenia Unknown status NCT00445497 Phase 3 amoxicillin-clavulanate potassium;ciprofloxacin
27 Monoclonal Antibodies in Detecting Residual Disease in Patients Who Have Been Treated for Non-Hodgkin's Lymphoma Unknown status NCT00003338 Phase 2, Phase 3
28 Radiolabeled Monoclonal Antibody in the Detection and Staging of Patients With Non-Hodgkin's Lymphoma Unknown status NCT00003337 Phase 3
29 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
30 Combination Chemotherapy With or Without Idarubicin and Peripheral Stem Cell Transplantation in Treating Patients With Leukemia or Myelodysplastic Syndrome Unknown status NCT00002989 Phase 3 busulfan;cyclophosphamide;idarubicin;melphalan
31 Interferon Alfa-2b Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Recurrent or Refractory Hodgkin's Disease or Non-Hodgkin's Lymphoma Unknown status NCT00003924 Phase 3
32 Randomized Trial of G-CSF Alone Versus Intermediate-dose Ara-C Plus G-CSF Mobilization in Hodgkin's Lymphoma or Non-Hodgkin's Lymphoma Unknown status NCT02722733 Phase 3 G-CSF (filgrastim);Cytosine arabinoside with G-CSF (filgrastim)
33 Mega-CHOEP: Conventional Chemo Vs HD Chemo Followed by Auto SCT in Younger Pts With Aggressive Non-Hodgkin's Lymphoma Unknown status NCT00129090 Phase 3 R-CHOEP 14 with 12x Rituximab
34 Zevalin and BEAM High-dose Chemotherapy Compared With BEAM Alone as Conditioning Regimen in Patients With Chemosensitive Relapse of Non-Hodgkin's Lymphoma Unknown status NCT00463463 Phase 3 90Yttrium Ibritumomab Tiuxetan (Zevalin)
35 A Study of Rituximab Versus Iodine I 131 Tositumomab Therapy for Patients With Non-Hodgkin's Lymphoma Unknown status NCT00078598 Phase 3 Rituximab or Iodine I 131 Tositumomab Therapy
36 Combination Chemotherapy Followed By Radiation Therapy in Treating Patients With Aggressive Non-Hodgkin's Lymphoma Unknown status NCT00053768 Phase 3 EPOCH regimen;cyclophosphamide;doxorubicin hydrochloride;etoposide;prednisone;vincristine sulfate
37 Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma Unknown status NCT00052936 Phase 3 CHOP regimen;cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
38 Combination Chemotherapy in Treating Children With Non-Hodgkin's Lymphoma Unknown status NCT00003423 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;mercaptopurine;methotrexate;prednisolone;thioguanine;vincristine sulfate
39 Fludarabine and Rituximab With or Without Pixantrone in Treating Patients With Relapsed or Refractory Indolent Non-Hodgkin Lymphoma Unknown status NCT00551239 Phase 3 fludarabine phosphate;pixantrone dimaleate
40 Combination Chemotherapy With or Without Interferon Alfa in Treating Patients With Low-Grade Non-Hodgkin's Lymphoma Unknown status NCT00003639 Phase 3 chlorambucil;dexamethasone;idarubicin
41 Combination Chemotherapy Plus Filgrastim With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma Unknown status NCT00028717 Phase 3 cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
42 Combination Chemotherapy Followed By Vaccine Therapy Plus Sargramostim in Treating Patients With Stage III or Stage IV Non-Hodgkin's Lymphoma Unknown status NCT00017290 Phase 3 cyclophosphamide;prednisone;vincristine sulfate
43 Combination Chemotherapy in Treating Children With Non-Hodgkin's Lymphoma Unknown status NCT00003650 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisone;vincristine sulfate
44 Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma Unknown status NCT00003728 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisolone;therapeutic hydrocortisone;thioguanine;vincristine sulfate;vindesine
45 Epratuzumab in Treating Patients With Non-Hodgkin's Lymphoma Unknown status NCT00022685 Phase 3
46 Safety and Efficacy Study of Bendamustine to Treat Non-Hodgkin Lymphoma Unknown status NCT01570049 Phase 3 Bendamustine
47 Chemotherapy and Radiation Therapy Plus Bone Marrow Transplantation in Treating Patients With Aggressive Non-Hodgkin's Lymphoma Unknown status NCT00003815 Phase 3 carmustine;cyclophosphamide;cytarabine;doxorubicin hydrochloride;etoposide;melphalan;prednisolone;vincristine sulfate
48 Study of the BiovaxId Tumor Derived Idiotype Vaccine in Patients With Follicular Lymphoma Unknown status NCT00091676 Phase 3
49 Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III or Stage IV Non-Hodgkin's Lymphoma Unknown status NCT00006250 Phase 3 chlorambucil;dexamethasone;fludarabine phosphate;mitoxantrone hydrochloride
50 High Dose Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Intermediate- or High-Grade Non-Hodgkin's Lymphoma Unknown status NCT00003578 Phase 3 CHOP regimen;carmustine;cyclophosphamide;cytarabine;doxorubicin hydrochloride;etoposide;melphalan;prednisone;vincristine sulfate

Search NIH Clinical Center for Lymphoma, Non-Hodgkin, Familial

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Lymphoma, Non-Hodgkin, Familial cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Lymphoma, Non-Hodgkin, Familial:
Blood stem cell transplantation for hematological diseases
Hematopoietic stem cells for treatment of hematologic malignancies
Hematopoietic stem cells for treatment of non-Hodgkin's lymphoma
StemEx, umbilical cord blood stem/progenitor cells for hematological diseases
Embryonic/Adult Cultured Cells Related to Lymphoma, Non-Hodgkin, Familial:
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived hematopoietic stem cells
Peripheral blood-derived hematopoietic stem cells PMIDs: 21831743
Umbilical cord blood stem/progenitor cells (Stemex) PMIDs: 18209724

Cochrane evidence based reviews: lymphoma, non-hodgkin

Sources

Genetic Tests for Lymphoma, Non-Hodgkin, Familial

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Genetic tests related to Lymphoma, Non-Hodgkin, Familial:

# Genetic test Affiliating Genes
1 Non-Hodgkin Lymphoma 30 BCL10 CASP10 PRF1 RAD54B RAD54L
Sources

Anatomical Context for Lymphoma, Non-Hodgkin, Familial

About this section

MalaCards organs/tissues related to Lymphoma, Non-Hodgkin, Familial:

42
B Cells, T Cells, Bone, Bone Marrow, Liver, Nk Cells, Myeloid
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Lymphoma, Non-Hodgkin, Familial:
# Tissue Anatomical CompartmentCell Relevance
1 Blood Hematopoietic Bone Marrow Hematopoietic Stem Cells Potential therapeutic candidate
2 Blood Peripheral Blood Mature B-Cells Affected by disease
Sources

Publications for Lymphoma, Non-Hodgkin, Familial

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Articles related to Lymphoma, Non-Hodgkin, Familial:

(show top 50) (show all 3164)
# Title Authors Year
1
Non-Hodgkin lymphoma presenting as acute pancreatitis: A rare occurrence. ( 30656020 )
2019
2
Febrile neutropenia-related care and associated costs in elderly patients with breast cancer, lung cancer, or non-Hodgkin lymphoma. ( 30993450 )
2019
3
Non-Hodgkin lymphoma mimicking cholangiocarcinoma. ( 31019345 )
2019
4
Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma. ( 30790227 )
2019
5
Shared Medical and Environmental Risk Factors in Dry Eye Syndrome, Sjogren's Syndrome, and B-Cell Non-Hodgkin Lymphoma: A Case-Control Study. ( 30805374 )
2019
6
Front-line management of non-Hodgkin lymphoma in Australia. Part 1: follicular lymphoma. ( 30230156 )
2019
7
The HDAC6-selective inhibitor is effective against non-Hodgkin lymphoma and synergizes with ibrutinib in follicular lymphoma. ( 30693983 )
2019
8
Clinical Outcomes of Fludarabine and Melphalan With an 800 cGy Total Body Irradiation Conditioning Regimen in Patients With Refractory or Relapsed Aggressive Non-Hodgkin Lymphoma Undergoing Allogeneic Hematopoietic Stem Cell Transplantation. ( 31014757 )
2019
9
Hematopoietic stem cell transplantation in children and adolescents with relapsed or refractory B-cell non-Hodgkin lymphoma. ( 30701466 )
2019
10
Complications and hospital costs during hematopoietic stem cell transplantation for non-Hodgkin lymphoma in the United States. ( 30848975 )
2019
11
Hepatitis C virus infection is a risk factor for non-Hodgkin lymphoma: A MOOSE-compliant meta-analysis. ( 30882645 )
2019
12
High Prevalence of Hepatitis C Virus among B-Cell Non Hodgkin Lymphoma Patients in Mansoura Region (Egypt), ANRS 12263 Study. ( 30671217 )
2019
13
Lamivudine prophylaxis prevents hepatitis B virus reactivation in anti-HBc positive patients under rituximab for non-Hodgkin lymphoma. ( 30316785 )
2019
14
Inotuzumab ozogamicin in clinical development for acute lymphoblastic leukemia and non-Hodgkin lymphoma. ( 31011424 )
2019
15
Population pharmacokinetics of inotuzumab ozogamicin in relapsed/refractory acute lymphoblastic leukemia and non-Hodgkin lymphoma. ( 30859374 )
2019
16
Zanubrutinib: a novel BTK inhibitor in chronic lymphocytic leukemia and non-Hodgkin lymphoma. ( 30843894 )
2019
17
Autopsy findings in patients with acute myeloid leukemia and non-Hodgkin lymphoma in the modern era: a focus on lung pathology and acute respiratory failure. ( 30218164 )
2019
18
Disparities in Trace Metal Levels in Hodgkin/Non-Hodgkin Lymphoma Patients in Comparison with Controls. ( 31098833 )
2019
19
Non-Hodgkin Lymphoma in a Kidney Transplant Patient: A Case Report. ( 31101215 )
2019
20
BCNU (Bis-chloroethylnitrosourea, Carmustine) Toxicity Presented as a Large Pleural Effusion 60 Days Post Autologous Stem Cell Transplant for Non-Hodgkin Lymphoma. ( 31019849 )
2019
21
Increasing levels of serum heat shock protein 70 precede the development of AIDS-defining non-Hodgkin lymphoma among carriers of HLA-B8-DR3. ( 31026237 )
2019
22
Non-Hodgkin Lymphoma With Longitudinally Extensive Transverse Myelopathy as the Initial Symptom: A Case Report. ( 31032227 )
2019
23
Vitamin D status and risk of non-Hodgkin lymphoma: An updated meta-analysis. ( 31034511 )
2019
24
Second primary cancers in non-Hodgkin lymphoma: family history and survival. ( 31054153 )
2019
25
Seroepidemiological analysis and literature review of the prevalence of Epstein-Barr virus and herpesvirus infections in pediatric cases with non-Hodgkin lymphoma in Central Europe. ( 30977593 )
2019
26
Non-Hodgkin Lymphoma in the Middle East Is Characterized by Low Incidence Rates With Advancing Age. ( 30978153 )
2019
27
Postchemotherapy Histiocyte-Rich Pseudotumor of the Spleen Simulating Residual Disease in a Patient With Non-Hodgkin Lymphoma on FDG PET/CT. ( 30985428 )
2019
28
Long-term results with the adapted LMB 96 protocol in children with B-cell non Hodgkin lymphoma treated in Iraq: comparison in two subsequent cohorts of patients. ( 30997873 )
2019
29
Pre-diagnostic blood levels of organochlorines and risk of non-Hodgkin lymphoma in three prospective cohorts in China and Singapore. ( 31001807 )
2019
30
Investigating the potential benefit of second biopsy of residual mass in pediatric mature B cell non-Hodgkin lymphoma. ( 31002269 )
2019
31
Pixantrone, etoposide, bendamustine, rituximab (P[R]EBEN) as an effective salvage regimen for relapsed/refractory aggressive non-Hodgkin lymphoma-Polish Lymphoma Research Group real-life analysis. ( 31003160 )
2019
32
The prognostic value of toll-like receptor5 and programmed cell death-ligand1 in patients with peripheral T-cell non-Hodgkin lymphoma. ( 31017033 )
2019
33
Recent advances in the first-line treatment of follicular non-Hodgkin lymphoma. ( 30906531 )
2019
34
B-cell non-Hodgkin lymphoma discovery after observation of a platelet satellitism around atypical lymphocytes. ( 30907360 )
2019
35
Cardiovascular mortality among patients with non-Hodgkin lymphoma: differences according to lymphoma subtype. ( 30916804 )
2019
36
Hematuria Alone or in Combination with Proteinuria Is a Harbinger of Poor Prognosis in Patients with Non-Hodgkin Lymphoma. ( 30921806 )
2019
37
Treatment modalities of non-Hodgkin lymphoma patients over 65 years of age: A two-center experience. ( 30924740 )
2019
38
Non-Hodgkin lymphoma risk and organophosphate and carbamate insecticide use in the north American pooled project. ( 30928843 )
2019
39
Novel Methods to Improve the Efficiency of Radioimmunotherapy for Non-Hodgkin Lymphoma. ( 30931651 )
2019
40
Polatuzumab vedotin or pinatuzumab vedotin plus rituximab in patients with relapsed or refractory non-Hodgkin lymphoma: final results from a phase 2 randomised study (ROMULUS). ( 30935953 )
2019
41
Characteristics, treatment patterns, prognostic determinants and outcome of peripheral T cell lymphoma and natural killer/T cell non-Hodgkin Lymphoma in older patients: The result of the nationwide multi-institutional registry Thai Lymphoma Study Group. ( 30940492 )
2019
42
Clinical characteristics and prognosis associated with multiple primary malignant tumors in non-Hodgkin lymphoma patients. ( 30945608 )
2019
43
Venetoclax plus R- or G-CHOP in non-Hodgkin lymphoma: results from the CAVALLI phase 1b trial. ( 30850381 )
2019
44
Concomitant occurrence of primary renal non-Hodgkin lymphoma and a colon cancer: A rare case report. ( 30855498 )
2019
45
Global patterns and trends in the incidence of non-Hodgkin lymphoma. ( 30895415 )
2019
46
Early evaluation of tumor response to 90Y-ibritumomab radioimmunotherapy in relapsed/refractory B cell non-Hodgkin lymphoma: what is the optimal timing for FDG-PET/CT? ( 30899979 )
2019
47
Long-term fatigue in survivors of non-Hodgkin lymphoma: The Lymphoma Study Association SIMONAL cross-sectional study. ( 30901086 )
2019
48
CAR T-Cell Therapy in Non-Hodgkin Lymphoma Patients. ( 30784033 )
2019
49
Duvelisib in indolent non-Hodgkin lymphoma. ( 30799261 )
2019
50
The effect of CRM1 inhibition on human non-Hodgkin lymphoma cells. ( 30808874 )
2019
Sources

Variations for Lymphoma, Non-Hodgkin, Familial

About this section

UniProtKB/Swiss-Prot genetic disease variations for Lymphoma, Non-Hodgkin, Familial:

76
# Symbol AA change Variation ID SNP ID
1 BRAF p.Gly469Ala VAR_018620 rs121913355
2 BRAF p.Gly469Arg VAR_018622 rs121913357
3 BRAF p.Asp594Gly VAR_018624 rs121913338
4 CASP10 p.Ala414Val VAR_037430 rs28936699

ClinVar genetic disease variations for Lymphoma, Non-Hodgkin, Familial:

6 (show top 50) (show all 110)
# Gene Variation Type Significance SNP ID Assembly Location
1 RAD54B NM_012415.3(RAD54B): c.1778A> G (p.Asn593Ser) single nucleotide variant Pathogenic rs114216685 GRCh37 Chromosome 8, 95403868: 95403868
2 RAD54B NM_012415.3(RAD54B): c.1778A> G (p.Asn593Ser) single nucleotide variant Pathogenic rs114216685 GRCh38 Chromosome 8, 94391640: 94391640
3 RAD54L NM_001142548.1(RAD54L): c.1331T> A (p.Val444Glu) single nucleotide variant Pathogenic rs121908689 GRCh37 Chromosome 1, 46738430: 46738430
4 RAD54L NM_001142548.1(RAD54L): c.1331T> A (p.Val444Glu) single nucleotide variant Pathogenic rs121908689 GRCh38 Chromosome 1, 46272758: 46272758
5 CASP10 NM_032977.3(CASP10): c.1241C> T (p.Ala414Val) single nucleotide variant Pathogenic rs28936699 GRCh37 Chromosome 2, 202074111: 202074111
6 CASP10 NM_032977.3(CASP10): c.1241C> T (p.Ala414Val) single nucleotide variant Pathogenic rs28936699 GRCh38 Chromosome 2, 201209388: 201209388
7 CASP10 NM_032977.3(CASP10): c.769C> T (p.Gln257Ter) single nucleotide variant Pathogenic rs121909775 GRCh37 Chromosome 2, 202070652: 202070652
8 CASP10 NM_032977.3(CASP10): c.769C> T (p.Gln257Ter) single nucleotide variant Pathogenic rs121909775 GRCh38 Chromosome 2, 201205929: 201205929
9 CASP10 NM_032977.3(CASP10): c.1042_1043insA (p.Gly348Glufs) insertion Pathogenic rs398122800 GRCh37 Chromosome 2, 202073912: 202073913
10 CASP10 NM_032977.3(CASP10): c.1042_1043insA (p.Gly348Glufs) insertion Pathogenic rs398122800 GRCh38 Chromosome 2, 201209189: 201209190
11 TP53 NM_000546.5(TP53): c.722C> T (p.Ser241Phe) single nucleotide variant Likely pathogenic rs28934573 GRCh37 Chromosome 17, 7577559: 7577559
12 TP53 NM_000546.5(TP53): c.722C> T (p.Ser241Phe) single nucleotide variant Likely pathogenic rs28934573 GRCh38 Chromosome 17, 7674241: 7674241
13 TP53 NM_000546.5(TP53): c.844C> T (p.Arg282Trp) single nucleotide variant Conflicting interpretations of pathogenicity rs28934574 GRCh37 Chromosome 17, 7577094: 7577094
14 TP53 NM_000546.5(TP53): c.844C> T (p.Arg282Trp) single nucleotide variant Conflicting interpretations of pathogenicity rs28934574 GRCh38 Chromosome 17, 7673776: 7673776
15 TP53 NM_000546.5(TP53): c.974G> T (p.Gly325Val) single nucleotide variant Uncertain significance rs121912659 GRCh37 Chromosome 17, 7576872: 7576872
16 TP53 NM_000546.5(TP53): c.974G> T (p.Gly325Val) single nucleotide variant Uncertain significance rs121912659 GRCh38 Chromosome 17, 7673554: 7673554
17 PRF1 NM_001083116.3(PRF1): c.1122G> A (p.Trp374Ter) single nucleotide variant Pathogenic rs104894176 GRCh37 Chromosome 10, 72358355: 72358355
18 PRF1 NM_001083116.3(PRF1): c.1122G> A (p.Trp374Ter) single nucleotide variant Pathogenic rs104894176 GRCh38 Chromosome 10, 70598599: 70598599
19 NRAS NM_002524.4(NRAS): c.37G> C (p.Gly13Arg) single nucleotide variant Pathogenic/Likely pathogenic rs121434595 GRCh37 Chromosome 1, 115258745: 115258745
20 NRAS NM_002524.4(NRAS): c.37G> C (p.Gly13Arg) single nucleotide variant Pathogenic/Likely pathogenic rs121434595 GRCh38 Chromosome 1, 114716124: 114716124
21 NRAS NM_002524.3(NRAS): c.38G> A (p.Gly13Asp) single nucleotide variant Pathogenic rs121434596 GRCh37 Chromosome 1, 115258744: 115258744
22 NRAS NM_002524.3(NRAS): c.38G> A (p.Gly13Asp) single nucleotide variant Pathogenic rs121434596 GRCh38 Chromosome 1, 114716123: 114716123
23 BRAF NM_004333.4(BRAF): c.1405G> C (p.Gly469Arg) single nucleotide variant Pathogenic rs121913357 GRCh37 Chromosome 7, 140481403: 140481403
24 BRAF NM_004333.4(BRAF): c.1405G> C (p.Gly469Arg) single nucleotide variant Pathogenic rs121913357 GRCh38 Chromosome 7, 140781603: 140781603
25 BRAF NM_004333.4(BRAF): c.1406G> C (p.Gly469Ala) single nucleotide variant Pathogenic rs121913355 GRCh37 Chromosome 7, 140481402: 140481402
26 BRAF NM_004333.4(BRAF): c.1406G> C (p.Gly469Ala) single nucleotide variant Pathogenic rs121913355 GRCh38 Chromosome 7, 140781602: 140781602
27 BRAF NM_004333.4(BRAF): c.1781A> G (p.Asp594Gly) single nucleotide variant Pathogenic rs121913338 GRCh37 Chromosome 7, 140453154: 140453154
28 BRAF NM_004333.4(BRAF): c.1781A> G (p.Asp594Gly) single nucleotide variant Pathogenic rs121913338 GRCh38 Chromosome 7, 140753354: 140753354
29 MYD88 NM_002468.5(MYD88): c.755T> C (p.Leu252Pro) single nucleotide variant Uncertain significance rs387907272 GRCh37 Chromosome 3, 38182641: 38182641
30 MYD88 NM_002468.5(MYD88): c.755T> C (p.Leu252Pro) single nucleotide variant Uncertain significance rs387907272 GRCh38 Chromosome 3, 38141150: 38141150
31 EZH2 NM_004456.4(EZH2): c.1937A> T (p.Tyr646Phe) single nucleotide variant Likely pathogenic rs267601394 GRCh37 Chromosome 7, 148508727: 148508727
32 EZH2 NM_004456.4(EZH2): c.1937A> T (p.Tyr646Phe) single nucleotide variant Likely pathogenic rs267601394 GRCh38 Chromosome 7, 148811635: 148811635
33 EZH2 NM_004456.4(EZH2): c.1937A> T (p.Tyr646Phe) single nucleotide variant Likely pathogenic rs267601394 NCBI36 Chromosome 7, 148139660: 148139660
34 EZH2 NM_004456.4(EZH2): c.1936T> C (p.Tyr646His) single nucleotide variant Likely pathogenic rs267601395 GRCh37 Chromosome 7, 148508728: 148508728
35 EZH2 NM_004456.4(EZH2): c.1936T> C (p.Tyr646His) single nucleotide variant Likely pathogenic rs267601395 GRCh38 Chromosome 7, 148811636: 148811636
36 EZH2 NM_004456.4(EZH2): c.1936T> C (p.Tyr646His) single nucleotide variant Likely pathogenic rs267601395 NCBI36 Chromosome 7, 148139661: 148139661
37 TP53 NM_000546.5(TP53): c.844C> G (p.Arg282Gly) single nucleotide variant Pathogenic rs28934574 GRCh37 Chromosome 17, 7577094: 7577094
38 TP53 NM_000546.5(TP53): c.844C> G (p.Arg282Gly) single nucleotide variant Pathogenic rs28934574 GRCh38 Chromosome 17, 7673776: 7673776
39 TP53 NM_000546.5(TP53): c.722C> G (p.Ser241Cys) single nucleotide variant Likely pathogenic rs28934573 GRCh38 Chromosome 17, 7674241: 7674241
40 TP53 NM_000546.5(TP53): c.722C> G (p.Ser241Cys) single nucleotide variant Likely pathogenic rs28934573 GRCh37 Chromosome 17, 7577559: 7577559
41 TP53 NM_000546.5(TP53): c.845G> A (p.Arg282Gln) single nucleotide variant Conflicting interpretations of pathogenicity rs730882008 GRCh37 Chromosome 17, 7577093: 7577093
42 TP53 NM_000546.5(TP53): c.845G> A (p.Arg282Gln) single nucleotide variant Conflicting interpretations of pathogenicity rs730882008 GRCh38 Chromosome 17, 7673775: 7673775
43 NRAS NM_002524.4(NRAS): c.38G> T (p.Gly13Val) single nucleotide variant Pathogenic/Likely pathogenic rs121434596 GRCh37 Chromosome 1, 115258744: 115258744
44 NRAS NM_002524.4(NRAS): c.38G> T (p.Gly13Val) single nucleotide variant Pathogenic/Likely pathogenic rs121434596 GRCh38 Chromosome 1, 114716123: 114716123
45 MAP2K1 NM_002755.3(MAP2K1): c.171G> C (p.Lys57Asn) single nucleotide variant Likely pathogenic rs869025608 GRCh37 Chromosome 15, 66727455: 66727455
46 MAP2K1 NM_002755.3(MAP2K1): c.171G> C (p.Lys57Asn) single nucleotide variant Likely pathogenic rs869025608 GRCh38 Chromosome 15, 66435117: 66435117
47 EZH2 NM_004456.4(EZH2): c.1936T> A (p.Tyr646Asn) single nucleotide variant Likely pathogenic rs267601395 GRCh37 Chromosome 7, 148508728: 148508728
48 EZH2 NM_004456.4(EZH2): c.1936T> A (p.Tyr646Asn) single nucleotide variant Likely pathogenic rs267601395 GRCh38 Chromosome 7, 148811636: 148811636
49 EZH2 NM_004456.4(EZH2): c.1937A> C (p.Tyr646Ser) single nucleotide variant Likely pathogenic rs267601394 GRCh37 Chromosome 7, 148508727: 148508727
50 EZH2 NM_004456.4(EZH2): c.1937A> C (p.Tyr646Ser) single nucleotide variant Likely pathogenic rs267601394 GRCh38 Chromosome 7, 148811635: 148811635

Copy number variations for Lymphoma, Non-Hodgkin, Familial from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 164351 22 36286416 36295356 Translate CEP1 Non-Hodgkin''s lymphomas
Sources

Expression for Lymphoma, Non-Hodgkin, Familial

About this section
Search GEO for disease gene expression data for Lymphoma, Non-Hodgkin, Familial.
Sources

Pathways for Lymphoma, Non-Hodgkin, Familial

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Pathways related to Lymphoma, Non-Hodgkin, Familial according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 14.05 BCL10 BCL6 BRAF CASP10 CCND1 IRF4
2
Cytokine Signaling in Immune system 67
Show member pathways
 13.34 BCL6 BRAF CCND1 IRF4 MYC NRAS
3
IL-2 Pathway 65
Show member pathways
 13.22 BCL10 BRAF CCND1 MYC NRAS PTPRC
4
Human cytomegalovirus infection 38
Show member pathways
 12.97 CASP10 CCND1 MYC NRAS PIK3CA TP53
5
Endometrial cancer 38
Show member pathways
 12.86 BRAF CCND1 MYC NRAS PIK3CA TP53
6
Pathways in cancer 38
12.8 ALK BRAF CCND1 MYC NRAS PIK3CA
7
Apoptosis Modulation and Signaling 1
Show member pathways
 12.76 CASP10 IRF4 MYC NRAS PIK3CA PRF1
8
Gastric cancer 38
Show member pathways
 12.75 BRAF CCND1 MYC NRAS PIK3CA TP53
9
Development HGF signaling pathway 23
Show member pathways
 12.72 BRAF NPM1 NRAS PIK3CA TP53
10
Glioma 38
Show member pathways
 12.68 ALK BRAF CCND1 NRAS PIK3CA TP53
11
NF-kappaB Signaling 4
12.56 BCL10 BCL6 IRF4 PAX5 PTPRC
12
T cell receptor signaling pathway 38
Show member pathways
 12.56 BCL10 IRF4 NRAS PIK3CA PTPRC
13
ErbB signaling pathway 1 38
Show member pathways
 12.53 BRAF CCND1 MYC NRAS PIK3CA TP53
14
MicroRNAs in cancer 38
12.51 CCND1 MYC NRAS PIK3CA TP53
15
Prolactin Signaling Pathway 1 38
Show member pathways
 12.47 CCND1 MYC NRAS PIK3CA
16
Apoptosis Pathway 73
Show member pathways
 12.44 CASP10 NRAS PIK3CA TP53
17
Development IGF-1 receptor signaling 23
Show member pathways
 12.4 CCND1 MYC PIK3CA TP53
18
JAK-STAT signaling pathway (KEGG) 66
Show member pathways
 12.39 CCND1 MYC NRAS PIK3CA PTPRC
19
Human T-cell leukemia virus 1 infection 38
12.36 CCND1 MYC NRAS PIK3CA TP53
20
Development EGFR signaling pathway 23
Show member pathways
 12.35 BRAF CASP10 CCND1 MYC NRAS PIK3CA
21
B Cell Receptor Signaling Pathway (sino) 68
Show member pathways
 12.33 BCL6 NRAS PIK3CA PTPRC
22
Viral carcinogenesis 38
12.3 CCND1 NRAS PIK3CA TP53
23
Transcriptional misregulation in cancer 38
12.26 BCL6 MYC PAX5 TP53
24
Colorectal Cancer Metastasis 65
12.18 BRAF CCND1 MYC TP53
25
mTOR Pathway 73
Show member pathways
 12.17 BRAF NRAS PIK3CA TP53
26
Cellular senescence (KEGG) 38
12.16 CCND1 MYC NRAS PIK3CA TP53
27
Proteoglycans in cancer 38
12.15 BRAF CCND1 MYC NRAS PIK3CA TP53
28
NGF Pathway 65
Show member pathways
 12.14 BRAF MYC NRAS TP53
29
MAPK Signaling: Mitogen Stimulation Pathway 66
Show member pathways
 12.14 BRAF CCND1 MYC NRAS PIK3CA TP53
30
AKT Signaling Pathway 68
12.13 CCND1 MYC NRAS PIK3CA TP53
31
Integrated Breast Cancer Pathway 1
12.13 BRAF CCND1 MYC RAD54L TP53
32
FoxO signaling pathway 38
Show member pathways
 12.06 BCL6 BRAF CCND1 NRAS PIK3CA
33
Thyroid hormone signaling pathway 38
11.92 CCND1 MYC NRAS PIK3CA TP53
34
AGE-RAGE signaling pathway in diabetic complications 38
11.9 CCND1 NRAS PIK3CA
35