MCID: LYM052
MIFTS: 44

Lymphomatoid Papulosis

Categories: Rare diseases, Skin diseases, Blood diseases, Immune diseases

Aliases & Classifications for Lymphomatoid Papulosis

MalaCards integrated aliases for Lymphomatoid Papulosis:

Name: Lymphomatoid Papulosis 53 59 55 73
Lyp 53 59

Characteristics:

Orphanet epidemiological data:

59
lymphomatoid papulosis
Inheritance: Not yet documented; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Orphanet 59 ORPHA98842
MESH via Orphanet 45 D017731
UMLS via Orphanet 74 C0206182
ICD10 via Orphanet 34 C86.6
ICD10 33 L41.2
UMLS 73 C0206182

Summaries for Lymphomatoid Papulosis

NIH Rare Diseases : 53 Lymphomatoid papulosis is a skin disorder that is characterized by crops of self healing skin lesions that look cancerous under the microscope but are actually benign (non-cancerous). Lesions contain unusual cells that are similar to those found in some lymphomas (cancers of the lymphatic system).

MalaCards based summary : Lymphomatoid Papulosis, also known as lyp, is related to anaplastic large cell lymphoma and lymphomatoid granulomatosis. An important gene associated with Lymphomatoid Papulosis is NPM1 (Nucleophosmin 1), and among its related pathways/superpathways are Influenza A and Development HGF signaling pathway. The drugs Lenalidomide and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and bone marrow, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Lymphomatoid papulosis (LyP) is a rare skin disorder. The overall prevalence rate of lymphomatoid... more...

Related Diseases for Lymphomatoid Papulosis

Diseases related to Lymphomatoid Papulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 anaplastic large cell lymphoma 30.8 ALK GZMB NPM1
2 lymphomatoid granulomatosis 30.2 GZMB TIA1
3 cutaneous t cell lymphoma 29.8 GZMB TIA1
4 peripheral t-cell lymphoma 29.6 ALK GZMB TIA1
5 primary cutaneous anaplastic large cell lymphoma 28.6 ALK GZMB NPM1 TIA1 TYK2
6 lymphoproliferative syndrome, x-linked, 1 11.4
7 lymphoma 10.8
8 mycosis fungoides 10.6
9 pityriasis lichenoides 10.5
10 autoimmune lymphoproliferative syndrome, type v 10.4
11 alk-positive anaplastic large cell lymphoma 10.4 ALK NPM1
12 lung lymphoma 10.3 ALK GZMB
13 orbit lymphoma 10.3 GZMB TIA1
14 lichen sclerosus et atrophicus 10.3 GZMB TIA1
15 viral esophagitis 10.3 GZMB TIA1
16 pityriasis lichenoides et varioliformis acuta 10.3
17 subcutaneous panniculitis-like t-cell lymphoma 10.3 GZMB TIA1
18 natural killer cell leukemia 10.3 GZMB TIA1
19 composite lymphoma 10.3 GZMB TIA1
20 hepatosplenic t-cell lymphoma 10.3 GZMB TIA1
21 giardiasis 10.2 GZMB TIA1
22 infiltrating lipoma 10.2 GZMB TIA1
23 histiocytosis 10.2
24 hypereosinophilic syndrome 10.2
25 necrotizing sialometaplasia 10.2 GZMB TIA1
26 leukemia 10.2
27 leukemia, chronic lymphocytic 2 10.1
28 leukemia, chronic lymphocytic 10.1
29 leukemia, b-cell, chronic 10.1
30 inflammatory myofibroblastic tumor 10.1 ALK NPM1
31 cowpox 10.1 FAS GZMB
32 ichthyosis 10.0
33 lymphosarcoma 10.0
34 b-cell lymphomas 10.0
35 multiple sclerosis 10.0
36 pyoderma 10.0
37 ichthyosis, acquired 10.0
38 myeloma, multiple 10.0
39 cll/sll 10.0
40 breast medullary carcinoma 9.9 FASLG GZMB
41 lymphoma, hodgkin, classic 9.9 ALK GZMB TIA1
42 t-cell large granular lymphocyte leukemia 9.9 FASLG GZMB
43 basal cell carcinoma 1 9.9
44 tuberculum sellae meningioma 9.9
45 basal cell carcinoma 9.9
46 scabies 9.9
47 ulcerative proctitis 9.9
48 transitional cell carcinoma 9.9
49 pyoderma gangrenosum 9.9
50 cytomegalovirus infection 9.9

Graphical network of the top 20 diseases related to Lymphomatoid Papulosis:



Diseases related to Lymphomatoid Papulosis

Symptoms & Phenotypes for Lymphomatoid Papulosis

GenomeRNAi Phenotypes related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.17 FAS GZMB TIA1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.17 FAS FASLG GZMB TIA1

MGI Mouse Phenotypes related to Lymphomatoid Papulosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.26 ALK FAS FASLG NPM1
2 skeleton MP:0005390 9.02 ALK FAS FASLG TIA1 TYK2

Drugs & Therapeutics for Lymphomatoid Papulosis

Drugs for Lymphomatoid Papulosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenalidomide Approved Phase 2 191732-72-6 216326
2 Angiogenesis Inhibitors Phase 2
3 Angiogenesis Modulating Agents Phase 2
4 Anti-Bacterial Agents Phase 2
5 Antibodies Phase 2
6 Immunoglobulins Phase 2
7 Antibodies, Monoclonal Phase 2
8 Immunosuppressive Agents Phase 2
9 Anti-Infective Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of SGN-30 (Anti-CD30 mAb) in Patients With Primary Cutaneous Anaplastic Large Cell Lymphoma Completed NCT00099255 Phase 2 SGN-30
2 Brentuximab Vedotin and Lenalidomide in Treating Patients With Stage IB-IVB Relapsed or Refractory T-Cell Lymphoma Recruiting NCT03409432 Phase 2 Brentuximab Vedotin;Lenalidomide
3 SGN-35 in CD30-positive Lymphoproliferative Disorders (ALCL), Mycosis Fungoides (MF), and Extensive Lymphomatoid Papulosis (LyP) Active, not recruiting NCT01352520 Phase 2 SGN-35
4 Tissue Repository: CTCL Collection Protocol Recruiting NCT02840747

Search NIH Clinical Center for Lymphomatoid Papulosis

Genetic Tests for Lymphomatoid Papulosis

Anatomical Context for Lymphomatoid Papulosis

MalaCards organs/tissues related to Lymphomatoid Papulosis:

41
Skin, T Cells, Bone Marrow, B Cells, Bone, Tongue, Colon

Publications for Lymphomatoid Papulosis

Articles related to Lymphomatoid Papulosis:

(show top 50) (show all 411)
# Title Authors Year
1
Lymphomatoid papulosis with folliculotropism, eccrinotropism and neurotropism. ( 29660166 )
2018
2
Lymphomatoid papulosis presenting as a rash in a patient with HIV infection. ( 29665741 )
2018
3
Type D (CD8+) lymphomatoid papulosis in a patient with classic (CD4+) mycosis fungoides. ( 29378678 )
2018
4
Lymphomatoid Papulosis (LyP) Associated with Diffuse Large B-cell Lymphoma and Cutaneous Anaplastic Large Cell Lymphoma: LyP as a Haematological Malignancy-related Dermadrome. ( 29796688 )
2018
5
Successful control of phototherapy-resistant lymphomatoid papulosis with oral bexarotene. ( 28971510 )
2018
6
First-line treatment in lymphomatoid papulosis: a retrospective multicentre study. ( 28994134 )
2018
7
Unilesional locally recurrent lymphomatoid papulosis with variable histological presentation. ( 28562138 )
2018
8
Lymphomatoid Contact Dermatitis Induced by Acrylates Mimicking Lymphomatoid Papulosis. ( 29570488 )
2018
9
Clinical evolution of lymphomatoid papulosis. ( 29808923 )
2018
10
Oral Lymphomatoid papulosis type C: A diagnostic pitfall, often confused with T-cell lymphoma. ( 29146059 )
2017
11
Dermoscopy of different stages of lymphomatoid papulosis. ( 29171911 )
2017
12
A Case of Lymphomatoid Papulosis Type E With an Unusual Exacerbated Clinical Course. ( 28937425 )
2017
13
Imatinib Treatment of Lymphomatoid Papulosis Associated with Myeloproliferative Hypereosinophilic Syndrome Presenting the FIP1L1-PDGFRA Fusion Gene. ( 28374041 )
2017
14
A Severe Case of Lymphomatoid Papulosis Type E Successfully Treated with Interferon-Alfa 2a. ( 28540091 )
2017
15
An unusual case of lymphomatoid papulosis type E with extensive necrosis. ( 29067932 )
2017
16
Lymphomatoid papulosis - making sense of the alphabet soup: a proposal to simplify terminology. ( 28252259 )
2017
17
Associated Hematolymphoid Malignancies in Patients With Lymphomatoid Papulosis: A Canadian Retrospective Study. ( 28614957 )
2017
18
Brentuximab Vedotin for Patients With Refractory Lymphomatoid Papulosis: An Analysis of Phase 2 Results. ( 28980004 )
2017
19
Lymphomatoid papulosis associated with chronic lymphocytic leukemia/small lymphocytic lymphoma: 3 cases. ( 28569995 )
2017
20
Histopathological aspects and differential diagnosis of CD8 positive lymphomatoid papulosis. ( 27461449 )
2016
21
Lymphomatoid Papulosis in a 2-Year-Old Girl With Markedly Elevated Antinuclear Antibodies. ( 28006986 )
2016
22
Human T-cell leukemia virus type 1-positive lymphomatoid papulosis. ( 26771231 )
2016
23
Lymphomatoid papulosis associated with multiple myeloma. ( 27230953 )
2016
24
Type D lymphomatoid papulosis simulating aggressive epidermotropic cytotoxic lymphoma. ( 26960644 )
2016
25
Lymphomatoid papulosis and fingolimod-A new connection? ( 26993118 )
2016
26
Regional lymphomatoid papulosis of the breast restricted to an area of prior radiotherapy. ( 27274553 )
2016
27
Lymphomatoid Papulosis Type D: Report of a Case in a Child and Review of the Literature. ( 26763888 )
2016
28
Pseudocarcinomatous Hyperplasia Hiding Lymphomatoid Papulosis: A "Low-Power View" Pitfall. ( 26711583 )
2016
29
Follicular lymphomatoid papulosis with follicular mucinosis: a clinicopathologic study of 3 cases with literature review and conceptual reappraisal. ( 28009441 )
2016
30
Follicular Lymphomatoid Papulosis: An Eosinophilic-Rich Follicular Subtype Masquerading as Folliculitis Clinically and Histologically. ( 26730698 )
2016
31
Lymphomatoid Papulosis in Children and Adolescents: A Systematic Review. ( 27138554 )
2016
32
Angioinvasive lymphomatoid papulosis (typeA E): a first Japanese case. ( 27267092 )
2016
33
A child with mastocytosis and lymphomatoid papulosis. ( 27190619 )
2016
34
Lymphomatoid papulosis type D in a fingolimod-treated multiple sclerosis patient. ( 27053634 )
2016
35
Frequency and Risk Factors for Associated Lymphomas in Patients With Lymphomatoid Papulosis. ( 26668250 )
2016
36
Shared clonality in distinctive lesions of lymphomatoid papulosis and mycosis fungoides occurring in the same patients suggests a common origin. ( 25666664 )
2015
37
Results of a Phase II Trial of Brentuximab Vedotin for CD30+ Cutaneous T-Cell Lymphoma and Lymphomatoid Papulosis. ( 26261247 )
2015
38
New variant lymphomatoid papulosis type E preceding and coexisting with mycosis fungoides - a case report and review of the literature. ( 26272365 )
2015
39
Self-healing Eyelid Nodule: A Quiz. Diagnosis: Lymphomatoid papulosis (LyP), type A. ( 25366062 )
2015
40
Atypical cutaneous I^I' T cell proliferation with morphologic features of lymphoma but with clinical features and course of PLEVA or lymphomatoid papulosis. ( 26263922 )
2015
41
The efficacy of methotrexate for lymphomatoid papulosis. ( 25981010 )
2015
42
Lymphomatoid papulosis in a young adult of African descent. ( 27051732 )
2015
43
Lymphomatoid papulosis associated with follicular B-cell lymphoma in lymph nodes. ( 26282183 )
2015
44
Commentary about papular mycosis fungoides, lymphomatoid papulosis, and lymphomatoid pityriasis lichenoides: More similarities than differences. ( 26566599 )
2015
45
Lymphomatoid papulosis: A cutaneous lymphoproliferative disorder in a patient on fingolimod for multiple sclerosis. ( 26219664 )
2015
46
Localized lymphomatoid papulosis. ( 25556677 )
2015
47
Recommendations for treatment of lymphomatoid papulosis with methotrexate: a report from the Dutch Cutaneous Lymphoma Group. ( 25998985 )
2015
48
Lymphomatoid papulosis: Treatment response and associated lymphomas in a study of 180 patients. ( 26518172 )
2015
49
Lymphomatoid papulosis with pseudocarcinomatous hyperplasia in a seven-year-old girl: a case report. ( 26531106 )
2015
50
Intralymphatic cutaneous anaplastic large cell lymphoma/lymphomatoid papulosis: expanding the spectrum of CD30-positive lymphoproliferative disorders. ( 24805854 )
2014

Variations for Lymphomatoid Papulosis

Expression for Lymphomatoid Papulosis

Search GEO for disease gene expression data for Lymphomatoid Papulosis.

Pathways for Lymphomatoid Papulosis

Pathways related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.44 FAS FASLG TYK2
2
Show member pathways
12.35 FAS FASLG NPM1
3
Show member pathways
12.2 FAS FASLG TYK2
4
Show member pathways
12.13 FAS FASLG GZMB
5
Show member pathways
12.09 FAS FASLG GZMB
6
Show member pathways
11.78 FAS FASLG TYK2
7 11.77 FAS FASLG GZMB TYK2
8
Show member pathways
11.69 FAS FASLG GZMB
9 11.67 ALK NPM1 TYK2
10
Show member pathways
11.49 FAS FASLG
11 11.42 FAS FASLG
12
Show member pathways
11.38 FASLG GZMB TYK2
13
Show member pathways
11.32 FASLG GZMB
14 11.23 FAS FASLG
15 11.19 FAS FASLG GZMB TIA1
16 11.14 FAS FASLG
17 10.98 FAS FASLG
18 10.95 TIA1 TYK2

GO Terms for Lymphomatoid Papulosis

Biological processes related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.56 FAS FASLG GZMB TIA1
2 regulation of cell proliferation GO:0042127 9.5 ALK FAS TYK2
3 apoptotic signaling pathway GO:0097190 9.43 FAS FASLG
4 extrinsic apoptotic signaling pathway GO:0097191 9.4 FAS FASLG
5 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.37 FAS FASLG
6 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.16 FAS FASLG
7 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 8.96 FAS FASLG
8 necroptotic signaling pathway GO:0097527 8.62 FAS FASLG

Sources for Lymphomatoid Papulosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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