LYP
MCID: LYM052
MIFTS: 44

Lymphomatoid Papulosis (LYP)

Categories: Blood diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Lymphomatoid Papulosis

MalaCards integrated aliases for Lymphomatoid Papulosis:

Name: Lymphomatoid Papulosis 54 60 56 17 74
Lyp 54 60

Characteristics:

Orphanet epidemiological data:

60
lymphomatoid papulosis
Inheritance: Not yet documented; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

ICD10 34 L41.2
MESH via Orphanet 46 D017731
ICD10 via Orphanet 35 C86.6
UMLS via Orphanet 75 C0206182
Orphanet 60 ORPHA98842
UMLS 74 C0206182

Summaries for Lymphomatoid Papulosis

NIH Rare Diseases : 54 Lymphomatoid papulosis (LyP) is a non-contagious, chronic skin condition characterized by the eruption of recurring, self-healing bumps (lesions) on the skin. The lesions typically begin small and then become larger, and they may bleed or ulcerate before becoming scaly and crusty. They often develop a red-brown color. Symptoms associated with lesions may include itching and/or pain, which may be debilitating. The frequency of eruptions varies over time and from person to person. Lesions may be very persistent, or they may go away for long periods of time before coming back. They may occur anywhere on the body, but they typically develop on the trunk, arms, and legs, and may develop on the hands, face, and genitalia. They generally go away on their own over a period of weeks to months (usually between 3 and 8 weeks), with or without scarring. LyP is not contagious. The cause of LyP is not known, but there is no evidence that it is hereditary. Stress is often reported to trigger eruptions of lesions. The duration of the condition varies from person to person and may last months, years or decades. A diagnosis of LyP requires evaluating the symptoms and having a skin biopsy for various types of laboratory tests. While LyP usually is not classified as a cancer (although there has been some debate), it has characteristics of lymphoma under the microscope, and people with LyP have a life-long increased risk of developing lymphoma such as mycosis fungoides, PC-ALCL, or Hodgkin lymphoma. In 5 to 20 percent of people with LyP, the condition is either preceded by lymphoma, associated with lymphoma, or followed by lymphoma. When LyP is diagnosed it is important to rule out these cancers, and for this reason, various blood tests or imaging studies may also be recommended. Treatment for LyP may speed up the healing of existing lesions or prevent new lesions from forming, but it does not change the overall course or duration of the condition. People with only a few lesions or with no major symptoms or cosmetic concerns may opt to forego treatment. If treatment is desired, topical corticosteroids are an option. Options for people with extensive skin lesions or debilitating symptoms may include topical steroids, phototherapy, oral or topical retinoids, methotrexate, or other medications (alone or in combination).Tetracycline is typically used if ulcerated lesions become infected. In most people with LyP-associated lymphomas, treatment of the lymphoma will also clear the LyP. The long-term outlook (prognosis) in more than 90% of people with LyP is positive, as it usually does not affect overall health. People with LyP who do not develop cancer have a normal life expectancy. While there is a substantial risk to develop lymphoma, the reported mortality rates from associated lymphomas are low.

MalaCards based summary : Lymphomatoid Papulosis, also known as lyp, is related to anaplastic large cell lymphoma and autoimmune lymphoproliferative syndrome, type v. An important gene associated with Lymphomatoid Papulosis is NPM1 (Nucleophosmin 1), and among its related pathways/superpathways are Apoptosis Modulation and Signaling and Development HGF signaling pathway. The drugs Lenalidomide and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 77 Lymphomatoid papulosis (LyP) is a rare skin disorder. The overall prevalence rate of lymphomatoid... more...

Related Diseases for Lymphomatoid Papulosis

Diseases related to Lymphomatoid Papulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Related Disease Score Top Affiliating Genes
1 anaplastic large cell lymphoma 31.2 ALK GZMB NPM1
2 autoimmune lymphoproliferative syndrome, type v 30.5 ALK FAS TIA1
3 cutaneous t cell lymphoma 30.3 GZMB TIA1
4 lymphomatoid granulomatosis 30.3 GZMB TIA1
5 peripheral t-cell lymphoma 30.0 ALK GZMB TIA1
6 lymphopenia 29.9 FAS FASLG
7 lymphoproliferative syndrome 29.9 FAS FASLG
8 primary cutaneous anaplastic large cell lymphoma 29.9 ALK GZMB NPM1 TIA1 TYK2
9 lymphoproliferative syndrome, x-linked, 1 11.6
10 lymphoma 11.0
11 mycosis fungoides 10.8
12 pityriasis lichenoides 10.7
13 pityriasis lichenoides et varioliformis acuta 10.5
14 leukemia 10.4
15 histiocytosis 10.4
16 hypereosinophilic syndrome 10.4
17 leukemia, chronic lymphocytic 2 10.3
18 leukemia, chronic lymphocytic 10.3
19 lymphocytic leukemia 10.3
20 leukemia, b-cell, chronic 10.3
21 cll/sll 10.3
22 autoimmune disease 10.2
23 autoimmune disease 1 10.2
24 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
25 distal trisomy 3p 10.2
26 multiple sclerosis 10.2
27 myeloma, multiple 10.2
28 b-cell lymphomas 10.2
29 ichthyosis 10.2
30 pyoderma 10.2
31 ichthyosis, acquired 10.2
32 alk-negative anaplastic large cell lymphoma 10.2
33 alk-positive anaplastic large cell lymphoma 10.2 ALK NPM1
34 lung lymphoma 10.2 ALK GZMB
35 orbit lymphoma 10.1 GZMB TIA1
36 lichen sclerosus et atrophicus 10.1 GZMB TIA1
37 viral esophagitis 10.1 GZMB TIA1
38 subcutaneous panniculitis-like t-cell lymphoma 10.1 GZMB TIA1
39 composite lymphoma 10.1 GZMB TIA1
40 hepatosplenic t-cell lymphoma 10.1 GZMB TIA1
41 natural killer cell leukemia 10.1 GZMB TIA1
42 giardiasis 10.1 GZMB TIA1
43 infiltrating lipoma 10.1 GZMB TIA1
44 necrotizing sialometaplasia 10.1 GZMB TIA1
45 ileum cancer 10.1 GZMB TIA1
46 angioimmunoblastic t-cell lymphoma 10.1 GZMB TIA1
47 rheumatoid arthritis 10.0
48 langerhans cell histiocytosis 10.0
49 basal cell carcinoma 1 10.0
50 arthritis 10.0

Graphical network of the top 20 diseases related to Lymphomatoid Papulosis:



Diseases related to Lymphomatoid Papulosis

Symptoms & Phenotypes for Lymphomatoid Papulosis

GenomeRNAi Phenotypes related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.17 FAS GZMB TIA1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.17 FAS FASLG GZMB TIA1

MGI Mouse Phenotypes related to Lymphomatoid Papulosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.26 ALK FAS FASLG NPM1
2 skeleton MP:0005390 9.02 ALK FAS FASLG TIA1 TYK2

Drugs & Therapeutics for Lymphomatoid Papulosis

Drugs for Lymphomatoid Papulosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenalidomide Approved Phase 2 191732-72-6 216326
2 Immunoglobulins Phase 2
3 Antibodies, Monoclonal Phase 2
4 Antibodies Phase 2
5 Immunologic Factors Phase 2
6 Antineoplastic Agents, Immunological Phase 2
7 Immunoconjugates Phase 2
8 Angiogenesis Inhibitors Phase 2
9 Angiogenesis Modulating Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of SGN-30 (Anti-CD30 mAb) in Patients With Primary Cutaneous Anaplastic Large Cell Lymphoma Completed NCT00099255 Phase 2 SGN-30
2 Dosing of Brentuximab Vedotin for Mycosis Fungoides, Sezary Syndrome Patients Recruiting NCT03587844 Phase 2 brentuximab vedotin;brentuximab vedotin;brentuximab vedotin
3 Brentuximab Vedotin and Lenalidomide in Treating Patients With Stage IB-IVB Relapsed or Refractory T-Cell Lymphoma Recruiting NCT03409432 Phase 2 Brentuximab Vedotin;Lenalidomide
4 SGN-35 in CD30-positive Lymphoproliferative Disorders (ALCL), Mycosis Fungoides (MF), and Extensive Lymphomatoid Papulosis (LyP) Active, not recruiting NCT01352520 Phase 2 SGN-35
5 Tissue Repository: CTCL Collection Protocol Recruiting NCT02840747

Search NIH Clinical Center for Lymphomatoid Papulosis

Genetic Tests for Lymphomatoid Papulosis

Anatomical Context for Lymphomatoid Papulosis

MalaCards organs/tissues related to Lymphomatoid Papulosis:

42
Skin, T Cells, Testes, Breast, Bone, Lymph Node, Bone Marrow

Publications for Lymphomatoid Papulosis

Articles related to Lymphomatoid Papulosis:

(show top 50) (show all 471)
# Title Authors Year
1
ALK-negative anaplastic large cell lymphoma arising in the thrombus of an aortic prosthesis preceeded by clonally related lymphomatoid papulosis. ( 30685783 )
2019
2
Efficacy of a novel LyP-1-containing self-microemulsifying drug delivery system (SMEDDS) for active targeting to breast cancer. ( 30660694 )
2019
3
γδ lymphomatoid papulosis type D: A histologic mimic of primary cutaneous γδ T-cell lymphoma. ( 30891476 )
2019
4
Photodynamic therapy prevented the recurrence of lymphomatoid papulosis. ( 30625399 )
2019
5
Type A lymphomatoid papulosis presenting as an eyelid ulcer in a young man. ( 30644803 )
2019
6
The penetrating properties of the tumor homing peptide LyP-1 in model lipid membranes. ( 30588706 )
2019
7
Recent progress in LyP-1-based strategies for targeted imaging and therapy. ( 30905205 )
2019
8
Lymphomatoid papulosis with folliculotropism, eccrinotropism and neurotropism. ( 29660166 )
2018
9
Lymphomatoid papulosis presenting as a rash in a patient with HIV infection. ( 29665741 )
2018
10
Type D (CD8+) lymphomatoid papulosis in a patient with classic (CD4+) mycosis fungoides. ( 29378678 )
2018
11
Lymphomatoid Papulosis (LyP) Associated with Diffuse Large B-cell Lymphoma and Cutaneous Anaplastic Large Cell Lymphoma: LyP as a Haematological Malignancy-related Dermadrome. ( 29796688 )
2018
12
Successful control of phototherapy-resistant lymphomatoid papulosis with oral bexarotene. ( 28971510 )
2018
13
First-line treatment in lymphomatoid papulosis: a retrospective multicentre study. ( 28994134 )
2018
14
Unilesional locally recurrent lymphomatoid papulosis with variable histological presentation. ( 28562138 )
2018
15
Lymphomatoid Contact Dermatitis Induced by Acrylates Mimicking Lymphomatoid Papulosis. ( 29570488 )
2018
16
Clinical evolution of lymphomatoid papulosis. ( 29808923 )
2018
17
Lymphomatoid papulosis in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma: case report and literature review. ( 30142733 )
2018
18
A case of lymphomatoid papulosis, pityriasis lichenoides acuta, and mycosis fungoides coexistence. ( 30198062 )
2018
19
The Alphabetization of Lymphomatoid Papulosis: Focus on "F". ( 30207529 )
2018
20
Type B lymphomatoid papulosis. ( 30374384 )
2018
21
Long-term Follow-up of a Case of Lymphomatoid Papulosis with a Benign Course. ( 30390731 )
2018
22
CD8-positive lymphomatoid papulosis (type D): Some lesions may lack CD30 expression and overlap histologically with mycosis fungoides. ( 30520526 )
2018
23
Lymphomatoid papulosis. ( 30677799 )
2018
24
CD30-Positive Angioinvasive Lymphomatoid Papulosis (Type E) Developing from Parapsoriasis en Plaque. ( 30687061 )
2018
25
Molecular dynamics, thermodynamic, and mutational binding studies for tumor-specific LyP-1 in complex with p32. ( 28427307 )
2018
26
LyP-1 Conjugated Nanoparticles for Magnetic Resonance Imaging of Triple Negative Breast Cancer. ( 29101636 )
2018
27
LyP-1-conjugated Fe3O4 nanoparticles suppress tumor growth by magnetic induction hyperthermia. ( 29165044 )
2018
28
Structure Reconstruction of LyP-1: Lc(LyP-1) Coupling by Amide Bond Inspires the Brain Metastatic Tumor Targeted Drug Delivery. ( 29215294 )
2018
29
Correction to: LyP-1 Conjugated Nanoparticles for Magnetic Resonance Imaging of Triple Negative Breast Cancer. ( 29556946 )
2018
30
Oral Lymphomatoid papulosis type C: A diagnostic pitfall, often confused with T-cell lymphoma. ( 29146059 )
2017
31
Dermoscopy of different stages of lymphomatoid papulosis. ( 29171911 )
2017
32
A Case of Lymphomatoid Papulosis Type E With an Unusual Exacerbated Clinical Course. ( 28937425 )
2017
33
Imatinib Treatment of Lymphomatoid Papulosis Associated with Myeloproliferative Hypereosinophilic Syndrome Presenting the FIP1L1-PDGFRA Fusion Gene. ( 28374041 )
2017
34
A Severe Case of Lymphomatoid Papulosis Type E Successfully Treated with Interferon-Alfa 2a. ( 28540091 )
2017
35
An unusual case of lymphomatoid papulosis type E with extensive necrosis. ( 29067932 )
2017
36
Lymphomatoid papulosis - making sense of the alphabet soup: a proposal to simplify terminology. ( 28252259 )
2017
37
Associated Hematolymphoid Malignancies in Patients With Lymphomatoid Papulosis: A Canadian Retrospective Study. ( 28614957 )
2017
38
Brentuximab Vedotin for Patients With Refractory Lymphomatoid Papulosis: An Analysis of Phase 2 Results. ( 28980004 )
2017
39
Lymphomatoid papulosis associated with chronic lymphocytic leukemia/small lymphocytic lymphoma: 3 cases. ( 28569995 )
2017
40
Magnetic mesoporous nanospheres anchored with LyP-1 as an efficient pancreatic cancer probe. ( 27871003 )
2017
41
Design and In Vitro Evaluation of Bispecific Complexes and Drug Conjugates of Anticancer Peptide, LyP-1 in Human Breast Cancer. ( 27896591 )
2017
42
Histopathological aspects and differential diagnosis of CD8 positive lymphomatoid papulosis. ( 27461449 )
2016
43
Lymphomatoid Papulosis in a 2-Year-Old Girl With Markedly Elevated Antinuclear Antibodies. ( 28006986 )
2016
44
Human T-cell leukemia virus type 1-positive lymphomatoid papulosis. ( 26771231 )
2016
45
Lymphomatoid papulosis associated with multiple myeloma. ( 27230953 )
2016
46
Type D lymphomatoid papulosis simulating aggressive epidermotropic cytotoxic lymphoma. ( 26960644 )
2016
47
Lymphomatoid papulosis and fingolimod-A new connection? ( 26993118 )
2016
48
Regional lymphomatoid papulosis of the breast restricted to an area of prior radiotherapy. ( 27274553 )
2016
49
Lymphomatoid Papulosis Type D: Report of a Case in a Child and Review of the Literature. ( 26763888 )
2016
50
Pseudocarcinomatous Hyperplasia Hiding Lymphomatoid Papulosis: A "Low-Power View" Pitfall. ( 26711583 )
2016

Variations for Lymphomatoid Papulosis

Expression for Lymphomatoid Papulosis

Search GEO for disease gene expression data for Lymphomatoid Papulosis.

Pathways for Lymphomatoid Papulosis

Pathways related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.45 FAS FASLG GZMB
2
Show member pathways
12.34 FAS FASLG NPM1
3
Show member pathways
12.22 FAS FASLG TYK2
4
Show member pathways
12.13 FAS FASLG GZMB
5
Show member pathways
12.09 FAS FASLG GZMB
6
Show member pathways
11.8 FAS FASLG GZMB
7 11.77 FAS FASLG GZMB TYK2
8
Show member pathways
11.74 FAS FASLG TYK2
9 11.6 ALK NPM1 TYK2
10
Show member pathways
11.48 FAS FASLG
11 11.41 FAS FASLG
12
Show member pathways
11.38 FASLG GZMB TYK2
13
Show member pathways
11.31 FASLG GZMB
14 11.22 FAS FASLG
15 11.19 FAS FASLG GZMB TIA1
16 11.14 FAS FASLG
17 11 FAS FASLG
18 10.95 TIA1 TYK2

GO Terms for Lymphomatoid Papulosis

Biological processes related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.46 FAS FASLG GZMB TIA1
2 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.4 FAS FASLG
3 apoptotic signaling pathway GO:0097190 9.37 FAS FASLG
4 extrinsic apoptotic signaling pathway GO:0097191 9.32 FAS FASLG
5 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.26 FAS FASLG
6 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 8.96 FAS FASLG
7 necroptotic signaling pathway GO:0097527 8.62 FAS FASLG

Sources for Lymphomatoid Papulosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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