MCID: LYM002
MIFTS: 37

Lymphoplasmacyte-Rich Meningioma

Categories: Cancer diseases, Immune diseases, Neuronal diseases

Aliases & Classifications for Lymphoplasmacyte-Rich Meningioma

MalaCards integrated aliases for Lymphoplasmacyte-Rich Meningioma:

Name: Lymphoplasmacyte-Rich Meningioma 12 15 17 74
Lymphoplasmocyte-Rich Meningioma 12
Meningioma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4591
NCIt 51 C4720
SNOMED-CT 69 19453003

Summaries for Lymphoplasmacyte-Rich Meningioma

MalaCards based summary : Lymphoplasmacyte-Rich Meningioma, also known as lymphoplasmocyte-rich meningioma, is related to spinal meningioma and meningioma, familial. An important gene associated with Lymphoplasmacyte-Rich Meningioma is MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Microglia Activation During Neuroinflammation: Microglia Polarization. The drugs Thrombin and Hemostatics have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and t cells, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Lymphoplasmacyte-Rich Meningioma

Diseases related to Lymphoplasmacyte-Rich Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 spinal meningioma 31.3 MIB1 PGR
2 meningioma, familial 30.6 CD68 PGR
3 secretory meningioma 10.8
4 rapidly involuting congenital hemangioma 10.5
5 idiopathic hypertrophic pachymeningitis 10.4
6 igg4-related pachymeningitis 10.4
7 rosai-dorfman disease 10.3
8 fibrous dysplasia 10.1
9 igg4-related disease 10.1
10 hyperostosis 10.1
11 histiocytosis 10.1
12 jugular foramen meningioma 10.1
13 viral esophagitis 10.1 CD68 CD79A
14 hodgkin's lymphoma, lymphocytic depletion 10.1 CD68 CD79A
15 small intestine lymphoma 10.1 CD79A UCHL1
16 lichen nitidus 10.1 CD68 UCHL1
17 ulcerative stomatitis 10.1 CD68 CD79A
18 lymphatic system cancer 10.1 CD79A UCHL1
19 central nervous system sarcoma 10.1 CD163 CD68
20 granular cell tumor 10.1 CD68 UCHL1
21 adult xanthogranuloma 10.1 CD163 CD68
22 spinal canal and spinal cord meningioma 10.1 MIB1 PGR
23 spleen cancer 10.1 CD163 CD68
24 petroclival meningioma 10.0 CD163 CD68
25 photokeratitis 10.0 CD163 CD68
26 indeterminate leprosy 10.0 CD68 UCHL1
27 calcific tendinitis 10.0 CD68 UCHL1
28 skin sarcoma 10.0 CD163 CD68
29 enterobiasis 10.0 CD163 CD68
30 dysgerminoma of ovary 9.9 CD79A PGR
31 solitary osseous plasmacytoma 9.9 CD79A SDC1
32 miliaria 9.9 CD68 SDC1
33 granulomatous endometritis 9.8 PGR SDC1
34 reticulohistiocytic granuloma 9.8 CD163 CD68 UCHL1
35 mature b-cell neoplasm 9.8 CD79A SDC1
36 synovitis 9.8 CD163 CD68
37 congenital epulis 9.7 CD68 PGR UCHL1
38 leukocyte disease 9.7 CD79A SDC1
39 leber congenital amaurosis 9.7 CD68 CD79A UCHL1

Graphical network of the top 20 diseases related to Lymphoplasmacyte-Rich Meningioma:



Diseases related to Lymphoplasmacyte-Rich Meningioma

Symptoms & Phenotypes for Lymphoplasmacyte-Rich Meningioma

GenomeRNAi Phenotypes related to Lymphoplasmacyte-Rich Meningioma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.17 CD163 CD79A
2 Decreased viability GR00381-A-2 9.17 CD163
3 Decreased viability GR00381-A-3 9.17 CD163 CD79A
4 Decreased viability GR00402-S-2 9.17 CD163 CD79A

MGI Mouse Phenotypes related to Lymphoplasmacyte-Rich Meningioma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 CD163 CD68 CD79A MIB1 PGR SDC1
2 no phenotypic analysis MP:0003012 8.92 CD68 CD79A MIB1 PGR

Drugs & Therapeutics for Lymphoplasmacyte-Rich Meningioma

Drugs for Lymphoplasmacyte-Rich Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 272)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved, Investigational Phase 4
2 Hemostatics Phase 4,Phase 3
3 Coagulants Phase 4,Phase 3
4 Fibrin Tissue Adhesive Phase 4
5
Tranexamic Acid Approved Phase 3 1197-18-8 5526
6
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
7
Mifepristone Approved, Investigational Phase 3 84371-65-3 55245
8
Donepezil Approved Phase 3,Phase 2,Early Phase 1 120014-06-4 3152
9
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
10
Ondansetron Approved Phase 3 99614-02-5 4595
11
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
12
Cisplatin Approved Phase 3,Phase 2 15663-27-1 2767 441203 84093
13
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1 50-02-2 5743
14
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 1 1177-87-3
15
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 3 7487-88-9 24083
16
Sevoflurane Approved, Vet_approved Phase 3 28523-86-6 5206
17
Cisatracurium Approved Phase 3 96946-41-7
18
Propofol Approved, Investigational, Vet_approved Phase 3 2078-54-8 4943
19
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
20
Dopamine Approved Phase 3 62-31-7, 51-61-6 681
21
Histamine Approved, Investigational Phase 3 51-45-6 774
22
Cyproheptadine Approved Phase 3 129-03-3 2913
23
Calcium Approved, Nutraceutical Phase 3,Phase 2,Phase 1 7440-70-2 271
24 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
25 Antifibrinolytic Agents Phase 3
26 Gastrointestinal Agents Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
27 Dermatologic Agents Phase 3,Phase 2,Phase 1
28 Hormone Antagonists Phase 3,Phase 2,Phase 1,Not Applicable
29 Luteolytic Agents Phase 3
30 Contraceptives, Oral Phase 3
31 Hormones Phase 3,Phase 2,Phase 1,Not Applicable
32 glucocorticoids Phase 3,Phase 1
33 Contraceptives, Postcoital Phase 3
34 Contraceptive Agents Phase 3
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1,Not Applicable
36 Progestins Phase 3
37 Cholinesterase Inhibitors Phase 3,Phase 2,Early Phase 1
38 Neurotransmitter Agents Phase 3,Phase 2,Phase 1,Early Phase 1
39 Nootropic Agents Phase 3,Phase 2,Early Phase 1
40 Cholinergic Agents Phase 3,Phase 2,Early Phase 1
41 Narcotics Phase 3
42 Adjuvants, Anesthesia Phase 3
43 Analgesics Phase 3,Phase 2,Phase 1
44 Anesthetics, Intravenous Phase 3
45 Liver Extracts Phase 3,Phase 1,Phase 2
46 Anesthetics, General Phase 3
47 Anesthetics Phase 3,Not Applicable
48 Analgesics, Opioid Phase 3
49 Central Nervous System Depressants Phase 3,Phase 2,Phase 1,Not Applicable
50 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 195)
# Name Status NCT ID Phase Drugs
1 Cavernous Sinus Dissection and Bleeding in Meningiomas Unknown status NCT02863484 Phase 4
2 Phase IV Bioseal Study in Brain Tumor Surgery Completed NCT02034799 Phase 4
3 Neurocognitive Outcome Assesment in Patients With Peri-optic Meningiomas After Excision With Or Without Pealing Of The Outer Layer Of The Cavernous Sinus: A Randomized Controlled Single Blinded Trial. Not yet recruiting NCT03190122 Phase 4
4 SCRT Versus Conventional RT in Children and Young Adults With Low Grade and Benign Brain Tumors Unknown status NCT00517959 Phase 3
5 Efficacy of Tranexamic Acid in Brain Tumor Resections Unknown status NCT01655927 Phase 3 Tranexamic Acid;Placebo: Saline
6 S9005 Mifepristone in Meningioma Completed NCT03015701 Phase 3 Mifepristone
7 Proton/Photon Rt - Benign Meningiomas(P92-13) Completed NCT02947984 Phase 3
8 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
9 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
10 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
11 Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery Recruiting NCT03180268 Phase 3
12 Magnesium and Intraoperative Blood Loss in Meningioma Surgery Not yet recruiting NCT03558516 Phase 3 Magnesium group;Normal saline group
13 Radiotherapy or Radiosurgery Compared With Observation Alone in Treating Patients With Newly Diagnosed, Benign Meningioma That Has Been Partially Removed by Surgery Terminated NCT00104936 Phase 3
14 Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors Terminated NCT00031798 Phase 3 methylphenidate hydrochloride
15 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
16 Combination of Everolimus and Octreotide LAR in Aggressive Recurrent Meningiomas Unknown status NCT02333565 Phase 2 Everolimus;Octreotide
17 Proton Radiation For Meningiomas and Hemangiopericytomas Unknown status NCT01117844 Phase 1, Phase 2
18 Hydroxyurea With or Without Imatinib Mesylate in Treating Patients With Recurrent or Progressive Meningioma Unknown status NCT00904735 Phase 2 hydroxyurea;imatinib mesylate
19 Hydroxyurea in Treating Patients With Recurrent and/or Unresectable Meningioma Unknown status NCT00006119 Phase 2 hydroxyurea
20 Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas Unknown status NCT01024907 Phase 1, Phase 2
21 Monthly SOM230C for Recurrent or Progressive Meningioma Completed NCT00859040 Phase 2 SOM230C
22 Trabectedin for Recurrent Grade II/III Meningioma Completed NCT02234050 Phase 2 Trabectedin
23 S9811 Hydroxyurea in Treating Patients With Unresectable Benign Meningioma Completed NCT00003590 Phase 2 hydroxyurea
24 Combination of Hydroxyurea and Verapamil for Refractory Meningiomas Completed NCT00706810 Phase 2 Hydroxyurea;Verapamil
25 Interferon Alfa in Treating Patients With Recurrent Unresectable Meningiomas and Malignant Meningiomas Completed NCT00002965 Phase 2
26 Radiation Therapy in Treating Patients Who Have Undergone Surgery for Newly Diagnosed Grade II or Grade III Meningioma Completed NCT00626730 Phase 2
27 Imatinib Mesylate in Treating Patients With Recurrent Meningioma Completed NCT00045734 Phase 2 imatinib mesylate
28 Phase II Trial of Sunitinib (SU011248) in Patients With Recurrent or Inoperable Meningioma Completed NCT00589784 Phase 2 Sunitinib
29 Vatalanib in Treating Patients With Recurrent or Progressive Meningioma Completed NCT00348790 Phase 2 vatalanib
30 Imatinib Mesylate and Hydroxyurea in Treating Patients With Recurrent or Progressive Meningioma Completed NCT00354913 Phase 2 hydroxyurea;imatinib mesylate
31 Imatinib Mesylate in Treating Patients With Recurrent Malignant Glioma or Meningioma Completed NCT00010049 Phase 1, Phase 2 imatinib mesylate
32 Erlotinib in Treating Patients With Recurrent Malignant Glioma or Recurrent or Progressive Meningioma Completed NCT00045110 Phase 1, Phase 2 erlotinib hydrochloride
33 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2 bevacizumab;placebo
34 Gefitinib in Treating Patients With Recurrent or Progressive CNS Tumors Completed NCT00025675 Phase 2 gefitinib
35 Phase II Study of Everolimus (RAD001) in Children and Adults With Neurofibromatosis Type 2 Completed NCT01419639 Phase 2 Everolimus (RAD001) , Afinitor®
36 Bevacizumab for Symptomatic Vestibular Schwannoma in Neurofibromatosis Type 2 (NF2) Completed NCT01207687 Phase 2
37 Irinotecan in Treating Children With Refractory Solid Tumors Completed NCT00004078 Phase 2 irinotecan hydrochloride
38 Bevacizumab and Irinotecan for Patients With Primary Brain Tumors and Progression After Standard Therapy Completed NCT00463203 Phase 2 Bevacizumab;Irinotecan
39 Armodafinil in Treating Fatigue Caused By Radiation Therapy in Patients With Primary Brain Tumors Completed NCT01032200 Phase 2 Armodafinil
40 Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors Completed NCT00629889 Phase 2 levetiracetam;pregabalin
41 Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin's Lymphoma Completed NCT00006102 Phase 2 becatecarin
42 Temozolomide Followed by Radiation Therapy in Treating Children With Newly Diagnosed Malignant CNS Tumors Completed NCT00005955 Phase 2 temozolomide
43 SU5416 in Treating Patients With Recurrent Astrocytoma or Mixed Glioma That Has Not Responded to Radiation Therapy Completed NCT00004868 Phase 1, Phase 2 semaxanib
44 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
45 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors Completed NCT00003461 Phase 1, Phase 2
46 Chemotherapy and Vaccine Therapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Recurrent or Refractory Brain Cancer Completed NCT00014573 Phase 2 carmustine;cisplatin;cyclophosphamide;paclitaxel
47 Lapatinib Study for Children and Adults With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT00973739 Phase 2 Lapatinib
48 Vistusertib (AZD2014) For Recurrent Grade II-III Meningiomas Recruiting NCT03071874 Phase 2 AZD2014
49 Phase II Trial of Pembrolizumab in Recurrent or Residual High Grade Meningioma Recruiting NCT03279692 Phase 2 Pembrolizumab
50 A Study of Nivolumab in Adult Participants With Recurrent High-Grade Meningioma Recruiting NCT02648997 Phase 2 Nivolumab

Search NIH Clinical Center for Lymphoplasmacyte-Rich Meningioma

Genetic Tests for Lymphoplasmacyte-Rich Meningioma

Anatomical Context for Lymphoplasmacyte-Rich Meningioma

MalaCards organs/tissues related to Lymphoplasmacyte-Rich Meningioma:

42
Brain, Bone, T Cells, Spinal Cord, Endothelial, Liver, Bone Marrow

Publications for Lymphoplasmacyte-Rich Meningioma

Articles related to Lymphoplasmacyte-Rich Meningioma:

(show all 31)
# Title Authors Year
1
Large dural-based mass with bony hyperostosis in a 16-year-old male: IgG4-related disease mimicking lymphoplasmacyte-rich meningioma. ( 31073682 )
2019
2
Editors' note: Lymphoplasmacyte-rich meningioma involving the whole intracranial dura mater. ( 30833477 )
2019
3
Reader response: Lymphoplasmacyte-rich meningioma involving the whole intracranial dura mater. ( 30833478 )
2019
4
Author response: Lymphoplasmacyte-rich meningioma involving the whole intracranial dura mater. ( 30833479 )
2019
5
Lymphoplasmacyte-Rich Meningioma With Atypical Angiomatous Feature and an Increased Deposition of IgG4-Positive Plasma Cells: An Unusual Case Report. ( 28862040 )
2018
6
Primary Intraosseous Lymphoplasmacyte-Rich Meningioma. ( 28962957 )
2018
7
Lymphoplasmacyte-rich meningioma involving the whole intracranial dura mater. ( 29759995 )
2018
8
Clinical, Radiologic, and Pathologic Features of 56 Cases of Intracranial Lymphoplasmacyte-Rich Meningioma. ( 28673887 )
2017
9
Report of a rare case of atypical lymphoplasmacyte-rich meningioma in the tentorium mimicking idiopathic hypertrophic pachymeningitis. ( 26902101 )
2016
10
Lymphoplasmacyte-rich meningioma with invasion of bone: A case report and review of literature. ( 27695559 )
2016
11
Isolated spinal Rosai-Dorfman disease misdiagnosed as lymphoplasmacyte-rich meningioma by intraoperative histological examination. ( 24577670 )
2015
12
Imaging findings and clinical features of intracal lymphoplasmacyte-rich meningioma. ( 25643346 )
2015
13
Intraventricular lymphoplasmacyte-rich meningioma: a case report. ( 25448216 )
2014
14
Gamma knife radiosurgery for lymphoplasmacyte-rich meningioma. ( 22964347 )
2013
15
Sphenoid wing lymphoplasmacyte-rich meningioma with occasional emperipolesis closely simulating an intracranial Rosai-Dorfman disease: a diagnostic dilemma. ( 23211432 )
2013
16
Lymphoplasmacyte-rich meningioma: our experience with 19 cases and a systematic literature review. ( 23936588 )
2013
17
An analysis of the magnetic resonance imaging and pathology of intracal lymphoplasmacyte-rich meningioma. ( 21354736 )
2012
18
Lymphoplasmacyte-rich meningioma: a convexity mass with regional enhancement in the adjacent brain parenchyma. ( 21732989 )
2012
19
A case of lymphoplasmacyte-rich meningioma of the jugular foramen. ( 21725644 )
2011
20
Lymphoplasmacyte-rich meningioma at the foramen magnum. ( 18661316 )
2008
21
Co-existing fibrous dysplasia and atypical lymphoplasmacyte-rich meningioma. ( 17645241 )
2007
22
Lymphoplasmacyte-rich meningioma mimicking idiopathic hypertrophic pachymeningitis. ( 17548990 )
2007
23
Idiopathic hypertrophic pachymeningitis mimicking lymphoplasmacyte-rich meningioma. ( 17548991 )
2007
24
Lymphoplasmacyte-rich meningioma with atypical invasive nature. ( 17245013 )
2007
25
Sphenoid ridge lymphoplasmacyte-rich meningioma. ( 16877241 )
2006
26
Lymphoplasmacyte rich meningioma. A case report and review of the literature. ( 15557881 )
2004
27
Cystic lymphoplasmacyte-rich meningioma--case report. ( 9095629 )
1997
28
Lymphoplasmacyte-rich meningioma with clinical resemblance to inflammatory pseudotumor. Report of two cases. ( 9126910 )
1997
29
Lymphoplasmacyte-rich meningioma: a case report with histological and immunohistochemical studies. ( 9384804 )
1997
30
Meningeal sinus histiocytosis mimicking lymphoplasmacyte-rich meningioma. Case report. ( 8847571 )
1996
31
Lymphoplasmacyte-rich meningioma in a child. Case report. ( 7490624 )
1995

Variations for Lymphoplasmacyte-Rich Meningioma

Expression for Lymphoplasmacyte-Rich Meningioma

Search GEO for disease gene expression data for Lymphoplasmacyte-Rich Meningioma.

Pathways for Lymphoplasmacyte-Rich Meningioma

Pathways related to Lymphoplasmacyte-Rich Meningioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.99 CD163 CD68 CD79A SDC1
2 10.81 CD163 CD68

GO Terms for Lymphoplasmacyte-Rich Meningioma

Cellular components related to Lymphoplasmacyte-Rich Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 CD163 CD79A SDC1

Sources for Lymphoplasmacyte-Rich Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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