EC1
MCID: LYS023
MIFTS: 15

Lysis by Alloreactive Natural Killer Cells (EC1)

Aliases & Classifications for Lysis by Alloreactive Natural Killer Cells

MalaCards integrated aliases for Lysis by Alloreactive Natural Killer Cells:

Name: Lysis by Alloreactive Natural Killer Cells 57
Susceptibility to Lysis by Alloreactive Natural Killer Cells 57 13
Lysis by Alloreactive Natural Killer Cells, Susceptibility to 57
Natural Killer Cell Susceptibility 1; Nks1 57
Natural Killer Cell Susceptibility 1 57
Nks1 57
Ec1 57

Characteristics:

OMIM®:

57 (Updated 05-Mar-2021)
Inheritance:
autosomal recessive


HPO:

31
lysis by alloreactive natural killer cells:
Inheritance autosomal recessive inheritance


External Ids:

OMIM® 57 272370
MedGen 41 C1848953
SNOMED-CT via HPO 68 258211005

Summaries for Lysis by Alloreactive Natural Killer Cells

OMIM® : 57 Susceptibility to lysis by alloreactive natural killer (NK) cells is an autosomal recessive trait (thus differing from the behavior of conventional MHC products) (Ciccone et al., 1990; Ciccone et al., 1990). (272370) (Updated 05-Mar-2021)

MalaCards based summary : Lysis by Alloreactive Natural Killer Cells, also known as susceptibility to lysis by alloreactive natural killer cells, is related to esophageal cancer and pemphigus vulgaris, familial. An important gene associated with Lysis by Alloreactive Natural Killer Cells is NKS1 (Natural Killer Cell Susceptibility 1). Affiliated tissues include nk cells, and related phenotype is abnormality of the immune system.

Related Diseases for Lysis by Alloreactive Natural Killer Cells

Diseases related to Lysis by Alloreactive Natural Killer Cells via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 esophageal cancer 10.0
2 pemphigus vulgaris, familial 10.0
3 pemphigus 10.0
4 breast cancer 9.9
5 ovarian cancer 9.9
6 polykaryocytosis inducer 9.9
7 camptodactyly syndrome, guadalajara, type i 9.9
8 epilepsy, childhood absence 1 9.9
9 branchiootic syndrome 1 9.9
10 helix syndrome 9.9
11 familial adenomatous polyposis 9.9
12 pemphigoid 9.9
13 squamous cell carcinoma 9.9
14 pancreatic adenocarcinoma 9.9
15 adenoma 9.9
16 bullous pemphigoid 9.9
17 48,xyyy 9.9

Graphical network of the top 20 diseases related to Lysis by Alloreactive Natural Killer Cells:



Diseases related to Lysis by Alloreactive Natural Killer Cells

Symptoms & Phenotypes for Lysis by Alloreactive Natural Killer Cells

Human phenotypes related to Lysis by Alloreactive Natural Killer Cells:

31
# Description HPO Frequency HPO Source Accession
1 abnormality of the immune system 31 HP:0002715

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Mar-2021)
Immunology:
alloreactive natural killer cell lysis susceptibility

Clinical features from OMIM®:

272370 (Updated 05-Mar-2021)

Drugs & Therapeutics for Lysis by Alloreactive Natural Killer Cells

Search Clinical Trials , NIH Clinical Center for Lysis by Alloreactive Natural Killer Cells

Genetic Tests for Lysis by Alloreactive Natural Killer Cells

Anatomical Context for Lysis by Alloreactive Natural Killer Cells

MalaCards organs/tissues related to Lysis by Alloreactive Natural Killer Cells:

40
Nk Cells

Publications for Lysis by Alloreactive Natural Killer Cells

Articles related to Lysis by Alloreactive Natural Killer Cells:

# Title Authors PMID Year
1
Susceptibility or resistance to lysis by alloreactive natural killer cells is governed by a gene in the human major histocompatibility complex between BF and HLA-B. 57 61
1979875 1990
2
Specific recognition of human CD3-CD16+ natural killer cells requires the expression of an autosomic recessive gene on target cells. 57
1694227 1990

Variations for Lysis by Alloreactive Natural Killer Cells

Expression for Lysis by Alloreactive Natural Killer Cells

Search GEO for disease gene expression data for Lysis by Alloreactive Natural Killer Cells.

Pathways for Lysis by Alloreactive Natural Killer Cells

GO Terms for Lysis by Alloreactive Natural Killer Cells

Sources for Lysis by Alloreactive Natural Killer Cells

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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