WM1
MCID: MCR161
MIFTS: 19

Macroglobulinemia, Waldenstrom 1 (WM1)

Categories: Blood diseases, Cancer diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Macroglobulinemia, Waldenstrom 1

MalaCards integrated aliases for Macroglobulinemia, Waldenstrom 1:

Name: Macroglobulinemia, Waldenstrom 1 57
Macroglobulinemia, Waldenstrom, Susceptibility to, 1 57 13
Wm1 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
macroglobulinemia, waldenstrom 1:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Macroglobulinemia, Waldenstrom 1

OMIM : 57 Waldenstrom macroglobulinemia (WM) is a malignant B-cell neoplasm characterized by lymphoplasmacytic infiltration of the bone marrow and hypersecretion of monoclonal immunoglobulin M (IgM) protein (review by Vijay and Gertz, 2007). The importance of genetic factors is suggested by the observation of familial clustering of WM (McMaster, 2003). Whereas WM is rare, an asymptomatic elevation of monoclonal IgM protein, termed 'IgM monoclonal gammopathy of undetermined significance' (IgM MGUS) is more common. Patients with IgM MGUS can progress to develop WM, at the rate of 1.5% to 2% per year (Kyle et al., 2003). (153600)

MalaCards based summary : Macroglobulinemia, Waldenstrom 1, also known as macroglobulinemia, waldenstrom, susceptibility to, 1, is related to waldenstrom macroglobulinemia. An important gene associated with Macroglobulinemia, Waldenstrom 1 is WM1 (Macroglobulinemia, Waldenstrom, Susceptibility To, 1). Affiliated tissues include bone, b cells and bone marrow, and related phenotypes are lymphoma and polyneuropathy

Related Diseases for Macroglobulinemia, Waldenstrom 1

Diseases in the Waldenstrom Macroglobulinemia family:

Macroglobulinemia, Waldenstrom 1 Macroglobulinemia, Waldenstrom 2

Diseases related to Macroglobulinemia, Waldenstrom 1 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 waldenstrom macroglobulinemia 11.1

Symptoms & Phenotypes for Macroglobulinemia, Waldenstrom 1

Symptoms via clinical synopsis from OMIM:

57
Neuro:
polyneuropathy

Heme:
waldenstrom macroglobulinemia

Lab:
polyclonal elevation of igm
impaired lymphocyte transformation with phytohemagglutinin

Oncology:
increased frequency of lymphoma, leukemia, and adenocarcinom of lung


Clinical features from OMIM:

153600

Human phenotypes related to Macroglobulinemia, Waldenstrom 1:

32 (show all 6)
# Description HPO Frequency HPO Source Accession
1 lymphoma 32 occasional (7.5%) HP:0002665
2 polyneuropathy 32 HP:0001271
3 polyclonal elevation of igm 32 HP:0003459
4 leukemia 32 occasional (7.5%) HP:0001909
5 monoclonal immunoglobulin m proteinemia 32 HP:0005508
6 impaired lymphocyte transformation with phytohemagglutinin 32 HP:0003347

Drugs & Therapeutics for Macroglobulinemia, Waldenstrom 1

Search Clinical Trials , NIH Clinical Center for Macroglobulinemia, Waldenstrom 1

Genetic Tests for Macroglobulinemia, Waldenstrom 1

Anatomical Context for Macroglobulinemia, Waldenstrom 1

MalaCards organs/tissues related to Macroglobulinemia, Waldenstrom 1:

41
Bone, B Cells, Bone Marrow, Lung

Publications for Macroglobulinemia, Waldenstrom 1

Variations for Macroglobulinemia, Waldenstrom 1

Expression for Macroglobulinemia, Waldenstrom 1

Search GEO for disease gene expression data for Macroglobulinemia, Waldenstrom 1.

Pathways for Macroglobulinemia, Waldenstrom 1

GO Terms for Macroglobulinemia, Waldenstrom 1

Sources for Macroglobulinemia, Waldenstrom 1

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62 PubMed
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69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
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74 UMLS via Orphanet
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