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WM1
MCID: MCR161
MIFTS: 19
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Macroglobulinemia, Waldenstrom 1 (WM1)
Categories:
Blood diseases, Cancer diseases, Immune diseases, Neuronal diseases, Rare diseases
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MalaCards integrated aliases for Macroglobulinemia, Waldenstrom 1:
Name: Macroglobulinemia, Waldenstrom 1
57
Characteristics:HPO:32Classifications:
MalaCards categories:
Global: Cancer diseases Rare diseases Anatomical: Neuronal diseases Blood diseases Immune diseases |
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OMIM
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57
Waldenstrom macroglobulinemia (WM) is a malignant B-cell neoplasm characterized by lymphoplasmacytic infiltration of the bone marrow and hypersecretion of monoclonal immunoglobulin M (IgM) protein (review by Vijay and Gertz, 2007). The importance of genetic factors is suggested by the observation of familial clustering of WM (McMaster, 2003). Whereas WM is rare, an asymptomatic elevation of monoclonal IgM protein, termed 'IgM monoclonal gammopathy of undetermined significance' (IgM MGUS) is more common. Patients with IgM MGUS can progress to develop WM, at the rate of 1.5% to 2% per year (Kyle et al., 2003).
(153600)
MalaCards based summary : Macroglobulinemia, Waldenstrom 1, also known as macroglobulinemia, waldenstrom, susceptibility to, 1, is related to waldenstrom macroglobulinemia. An important gene associated with Macroglobulinemia, Waldenstrom 1 is WM1 (Macroglobulinemia, Waldenstrom, Susceptibility To, 1). Affiliated tissues include bone, b cells and bone marrow, and related phenotypes are lymphoma and polyneuropathy |
Diseases in the Waldenstrom Macroglobulinemia family:
Diseases related to Macroglobulinemia, Waldenstrom 1 via text searches within MalaCards or GeneCards Suite gene sharing:
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Symptoms via clinical synopsis from OMIM:57Clinical features from OMIM:153600Human phenotypes related to Macroglobulinemia, Waldenstrom 1:32 (show all 6)
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MalaCards organs/tissues related to Macroglobulinemia, Waldenstrom 1:41
Bone,
B Cells,
Bone Marrow,
Lung
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Search
GEO
for disease gene expression data for Macroglobulinemia, Waldenstrom 1.
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