ARMD10
MCID: MCL030
MIFTS: 29

Macular Degeneration, Age-Related, 10 (ARMD10)

Categories: Blood diseases, Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Macular Degeneration, Age-Related, 10

MalaCards integrated aliases for Macular Degeneration, Age-Related, 10:

Name: Macular Degeneration, Age-Related, 10 56 73 13 71
Armd10 56 12 73
Age Related Macular Degeneration 10 12 15
Macular Degeneration, Age-Related, Type 10 39
Age-Related Macular Degeneration 10 29

Classifications:



External Ids:

Disease Ontology 12 DOID:0110022
OMIM 56 611488
OMIM Phenotypic Series 56 PS603075
MeSH 43 D008268
MedGen 41 C1969108
UMLS 71 C1969108

Summaries for Macular Degeneration, Age-Related, 10

UniProtKB/Swiss-Prot : 73 Macular degeneration, age-related, 10: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.

MalaCards based summary : Macular Degeneration, Age-Related, 10, also known as armd10, is related to macular degeneration, age-related, 1 and eye disease. An important gene associated with Macular Degeneration, Age-Related, 10 is ARMD10 (Macular Degeneration, Age-Related, 10), and among its related pathways/superpathways are Vitamin A and Carotenoid Metabolism and Surfactant metabolism. The drugs Bevacizumab and Mitogens have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 An age related macular degeneration associated with variation in the genomic region 9:112,100,000-127,500,000 (GRCh38). TLR4 has been put forth as a candidate gene.

More information from OMIM: 611488 PS603075

Related Diseases for Macular Degeneration, Age-Related, 10

Graphical network of the top 20 diseases related to Macular Degeneration, Age-Related, 10:



Diseases related to Macular Degeneration, Age-Related, 10

Symptoms & Phenotypes for Macular Degeneration, Age-Related, 10

Clinical features from OMIM:

611488

GenomeRNAi Phenotypes related to Macular Degeneration, Age-Related, 10 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-147 9.23 PNLIPRP1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.23 PNLIPRP1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-150 9.23 RETSAT
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-161 9.23 PNLIPRP1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.23 PNLIPRP1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-208 9.23 RETSAT
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.23 RETSAT
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.23 PNLIPRP1

Drugs & Therapeutics for Macular Degeneration, Age-Related, 10

Drugs for Macular Degeneration, Age-Related, 10 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4 216974-75-3
2 Mitogens Phase 4
3 Endothelial Growth Factors Phase 4
4 Angiogenesis Inhibitors Phase 4
5 Antineoplastic Agents, Immunological Phase 4
6 Pharmaceutical Solutions Phase 2
7 Ophthalmic Solutions Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Role of Unilateral Intravitreal Bevacizumab (Avastin), for the Treatment of Bilateral Diabetic Macular Edema: a Pilot Study. Completed NCT00496405 Phase 4 bevacizumab
2 An Open-label, Phase 2a Study to Evaluate Pazopanib Eye Drops Administered for 12 Weeks to Patients With Neovascular Age-related Macular Degeneration Terminated NCT01362348 Phase 2 pazopanib eye drops

Search NIH Clinical Center for Macular Degeneration, Age-Related, 10

Genetic Tests for Macular Degeneration, Age-Related, 10

Genetic tests related to Macular Degeneration, Age-Related, 10:

# Genetic test Affiliating Genes
1 Age-Related Macular Degeneration 10 29

Anatomical Context for Macular Degeneration, Age-Related, 10

MalaCards organs/tissues related to Macular Degeneration, Age-Related, 10:

40
Eye, Endothelial

Publications for Macular Degeneration, Age-Related, 10

Articles related to Macular Degeneration, Age-Related, 10:

(show all 15)
# Title Authors PMID Year
1
CFH and ARMS2 genetic polymorphisms predict response to antioxidants and zinc in patients with age-related macular degeneration. 6
23972322 2013
2
An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD). 6
20843825 2010
3
Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency. 6
18006700 2008
4
Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome. 6
17367211 2007
5
A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration. 6
16998489 2006
6
Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration. 56
15829498 2005
7
Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration. 56
14691731 2004
8
Age-related macular degeneration--a genome scan in extended families. 56
12900797 2003
9
Reliability of colour perimetry to assess macular pigment optical density in age-related macular degeneration. 61
31422700 2019
10
[Age-related macular degeneration: 10 key messages]. 61
30512452 2017
11
European survey on the opinion and use of micronutrition in age-related macular degeneration: 10 years on from the Age-Related Eye Disease Study. 61
25336904 2014
12
Five year incidence of visual field loss in adult Chinese. The Beijing Eye Study. 61
22624000 2012
13
Vision loss in Australia. 61
15938683 2005
14
Change in full-field ERGs after macular translocation surgery with 360 degrees retinotomy. 61
11818390 2002
15
Epidemiological aspects of visual impairment above 50 years in a rural area. 61
7890940 1994

Variations for Macular Degeneration, Age-Related, 10

Expression for Macular Degeneration, Age-Related, 10

Search GEO for disease gene expression data for Macular Degeneration, Age-Related, 10.

Pathways for Macular Degeneration, Age-Related, 10

Pathways related to Macular Degeneration, Age-Related, 10 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.6 RETSAT BCO2
2
Show member pathways
10.26 PGA4 PGA3

GO Terms for Macular Degeneration, Age-Related, 10

Cellular components related to Macular Degeneration, Age-Related, 10 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multivesicular body lumen GO:0097486 8.62 PGA4 PGA3

Biological processes related to Macular Degeneration, Age-Related, 10 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein catabolic process GO:0030163 8.96 PGA4 PGA3
2 digestion GO:0007586 8.62 PGA4 PGA3

Molecular functions related to Macular Degeneration, Age-Related, 10 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aspartic-type endopeptidase activity GO:0004190 8.62 PGA4 PGA3

Sources for Macular Degeneration, Age-Related, 10

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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