MCID: MCL030
MIFTS: 22

Macular Degeneration, Age-Related, 10

Categories: Eye diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Macular Degeneration, Age-Related, 10

MalaCards integrated aliases for Macular Degeneration, Age-Related, 10:

Name: Macular Degeneration, Age-Related, 10 57 75 13 73
Armd10 57 12 75
Macular Degeneration, Age-Related, Type 10 40
Age Related Macular Degeneration 10 12
Age-Related Macular Degeneration 10 29

Classifications:



External Ids:

OMIM 57 611488
Disease Ontology 12 DOID:0110022
MedGen 42 C1969108
MeSH 44 D008268
UMLS 73 C1969108

Summaries for Macular Degeneration, Age-Related, 10

UniProtKB/Swiss-Prot : 75 Macular degeneration, age-related, 10: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.

MalaCards based summary : Macular Degeneration, Age-Related, 10, also known as armd10, is related to macular degeneration, age-related, 1. An important gene associated with Macular Degeneration, Age-Related, 10 is TLR4 (Toll Like Receptor 4). The drugs Bevacizumab and Ranibizumab have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial.

Disease Ontology : 12 An age related macular degeneration associated with variation in the genomic region 9:112,100,000-127,500,000 (GRCh38). TLR4 has been put forth as a candidate gene.

Description from OMIM: 611488

Related Diseases for Macular Degeneration, Age-Related, 10

Symptoms & Phenotypes for Macular Degeneration, Age-Related, 10

Clinical features from OMIM:

611488

Drugs & Therapeutics for Macular Degeneration, Age-Related, 10

Drugs for Macular Degeneration, Age-Related, 10 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 2 216974-75-3
2
Ranibizumab Approved Phase 2 347396-82-1 459903
3 Angiogenesis Inhibitors Phase 2
4 Angiogenesis Modulating Agents Phase 2
5 Endothelial Growth Factors Phase 2
6 Mitogens Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 X-82 to Treat Age-related Macular Degeneration Terminated NCT02348359 Phase 2 X-82;Anti-VEGF;Placebo

Search NIH Clinical Center for Macular Degeneration, Age-Related, 10

Genetic Tests for Macular Degeneration, Age-Related, 10

Genetic tests related to Macular Degeneration, Age-Related, 10:

# Genetic test Affiliating Genes
1 Age-Related Macular Degeneration 10 29 TLR4

Anatomical Context for Macular Degeneration, Age-Related, 10

MalaCards organs/tissues related to Macular Degeneration, Age-Related, 10:

41
Eye, Endothelial

Publications for Macular Degeneration, Age-Related, 10

Articles related to Macular Degeneration, Age-Related, 10:

# Title Authors Year
1
European survey on the opinion and use of micronutrition in age-related macular degeneration: 10 years on from the Age-Related Eye Disease Study. ( 25336904 )
2014

Variations for Macular Degeneration, Age-Related, 10

Expression for Macular Degeneration, Age-Related, 10

Search GEO for disease gene expression data for Macular Degeneration, Age-Related, 10.

Pathways for Macular Degeneration, Age-Related, 10

GO Terms for Macular Degeneration, Age-Related, 10

Sources for Macular Degeneration, Age-Related, 10

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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