ARMD10
MCID: MCL030
MIFTS: 24

Macular Degeneration, Age-Related, 10 (ARMD10)

Categories: Blood diseases, Eye diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Macular Degeneration, Age-Related, 10

MalaCards integrated aliases for Macular Degeneration, Age-Related, 10:

Name: Macular Degeneration, Age-Related, 10 57 72 13 70
Armd10 57 12 72
Age Related Macular Degeneration 10 12 15
Macular Degeneration, Age-Related, Type 10 39
Age-Related Macular Degeneration 10 29

Classifications:



External Ids:

Disease Ontology 12 DOID:0110022
OMIM® 57 611488
OMIM Phenotypic Series 57 PS603075
MeSH 44 D008268
MedGen 41 C1969108
UMLS 70 C1969108

Summaries for Macular Degeneration, Age-Related, 10

UniProtKB/Swiss-Prot : 72 Macular degeneration, age-related, 10: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.

MalaCards based summary : Macular Degeneration, Age-Related, 10, also known as armd10, is related to macular degeneration, age-related, 1 and eye disease. An important gene associated with Macular Degeneration, Age-Related, 10 is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways is Surfactant metabolism. Affiliated tissues include eye, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 An age related macular degeneration associated with variation in the genomic region 9:112,100,000-127,500,000 (GRCh38). TLR4 has been put forth as a candidate gene.

More information from OMIM: 611488 PS603075

Related Diseases for Macular Degeneration, Age-Related, 10

Graphical network of the top 20 diseases related to Macular Degeneration, Age-Related, 10:



Diseases related to Macular Degeneration, Age-Related, 10

Symptoms & Phenotypes for Macular Degeneration, Age-Related, 10

Clinical features from OMIM®:

611488 (Updated 05-Apr-2021)

GenomeRNAi Phenotypes related to Macular Degeneration, Age-Related, 10 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-147 9.23 PNLIPRP1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.23 PNLIPRP1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-150 9.23 RETSAT
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-161 9.23 PNLIPRP1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.23 PNLIPRP1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-208 9.23 RETSAT
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.23 RETSAT
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.23 PNLIPRP1

Drugs & Therapeutics for Macular Degeneration, Age-Related, 10

Search Clinical Trials , NIH Clinical Center for Macular Degeneration, Age-Related, 10

Genetic Tests for Macular Degeneration, Age-Related, 10

Genetic tests related to Macular Degeneration, Age-Related, 10:

# Genetic test Affiliating Genes
1 Age-Related Macular Degeneration 10 29

Anatomical Context for Macular Degeneration, Age-Related, 10

MalaCards organs/tissues related to Macular Degeneration, Age-Related, 10:

40
Eye

Publications for Macular Degeneration, Age-Related, 10

Articles related to Macular Degeneration, Age-Related, 10:

# Title Authors PMID Year
1
Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration. 57
15829498 2005
2
Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration. 57
14691731 2004
3
Age-related macular degeneration--a genome scan in extended families. 57
12900797 2003
4
Reliability of colour perimetry to assess macular pigment optical density in age-related macular degeneration. 61
31422700 2020
5
[Age-related macular degeneration: 10 key messages]. 61
30512452 2017
6
European survey on the opinion and use of micronutrition in age-related macular degeneration: 10 years on from the Age-Related Eye Disease Study. 61
25336904 2014
7
Five year incidence of visual field loss in adult Chinese. The Beijing Eye Study. 61
22624000 2012
8
Vision loss in Australia. 61
15938683 2005
9
Change in full-field ERGs after macular translocation surgery with 360 degrees retinotomy. 61
11818390 2002
10
Epidemiological aspects of visual impairment above 50 years in a rural area. 61
7890940 1994

Variations for Macular Degeneration, Age-Related, 10

Expression for Macular Degeneration, Age-Related, 10

Search GEO for disease gene expression data for Macular Degeneration, Age-Related, 10.

Pathways for Macular Degeneration, Age-Related, 10

Pathways related to Macular Degeneration, Age-Related, 10 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.26 PGA4 PGA3

GO Terms for Macular Degeneration, Age-Related, 10

Cellular components related to Macular Degeneration, Age-Related, 10 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multivesicular body lumen GO:0097486 8.62 PGA4 PGA3

Biological processes related to Macular Degeneration, Age-Related, 10 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 digestion GO:0007586 8.62 PGA4 PGA3

Molecular functions related to Macular Degeneration, Age-Related, 10 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aspartic-type endopeptidase activity GO:0004190 8.62 PGA4 PGA3

Sources for Macular Degeneration, Age-Related, 10

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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