ARMD4
MCID: MCL038
MIFTS: 36

Macular Degeneration, Age-Related, 4 (ARMD4)

Categories: Blood diseases, Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Macular Degeneration, Age-Related, 4

MalaCards integrated aliases for Macular Degeneration, Age-Related, 4:

Name: Macular Degeneration, Age-Related, 4 56 73 13 71
Armd4 56 12 73
Age Related Macular Degeneration 4 12 15
Age-Related Macular Degeneration 4 29 6
Macular Degeneration, Age-Related, Type 4 39

Characteristics:

HPO:

31
macular degeneration, age-related, 4:
Inheritance polygenic inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:0110017
OMIM 56 610698
OMIM Phenotypic Series 56 PS603075
MeSH 43 D008268
MedGen 41 C1853147
SNOMED-CT via HPO 68 422338006
UMLS 71 C1853147

Summaries for Macular Degeneration, Age-Related, 4

UniProtKB/Swiss-Prot : 73 Macular degeneration, age-related, 4: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.

MalaCards based summary : Macular Degeneration, Age-Related, 4, also known as armd4, is related to macular degeneration, age-related, 1 and stargardt macular degeneration. An important gene associated with Macular Degeneration, Age-Related, 4 is CFH (Complement Factor H). Affiliated tissues include eye, retina and testes, and related phenotypes are macular degeneration and Increased number of mitotic cells

Disease Ontology : 12 An age related macular degeneration conferred by variation in the CFH gene on chromosome 1q31.

More information from OMIM: 610698 PS603075

Related Diseases for Macular Degeneration, Age-Related, 4

Diseases in the Macular Degeneration, Early-Onset family:

Macular Degeneration, Age-Related, 2 Macular Degeneration, Age-Related, 1
Macular Degeneration, Age-Related, 7 Macular Degeneration, Age-Related, 4
Macular Degeneration, Age-Related, 9 Macular Degeneration, Age-Related, 10
Macular Degeneration, Age-Related, 11 Macular Degeneration, Age-Related, 6
Macular Degeneration, Age-Related, 5 Macular Degeneration, Age-Related, 8
Macular Degeneration, Age-Related, 12 Macular Degeneration, Age-Related, 13
Macular Degeneration, Age-Related, 14 Macular Degeneration, Age-Related, 15

Diseases related to Macular Degeneration, Age-Related, 4 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 macular degeneration, age-related, 1 28.7 STT3A SFTA3 ELOVL4 CFH CFB BEST1
2 stargardt macular degeneration 10.4 ELOVL4 ABCA4
3 chorioretinal scar 10.3 BEST1 ABCA4
4 retinitis pigmentosa 19 10.3 ELOVL4 ABCA4
5 interval angle-closure glaucoma 10.3 BEST1 ABCA4
6 atypical hemolytic uremic syndrome with complement gene abnormality 10.3 CFH CFB
7 multifocal choroiditis 10.3 CFH CFB
8 dense deposit disease 10.3 CFH CFB
9 yemenite deaf-blind hypopigmentation syndrome 10.3 CFH ABCA4
10 bestrophinopathy, autosomal recessive 10.3 BEST1 ABCA4
11 genetic atypical hemolytic-uremic syndrome 10.2 CFH CFB
12 c3 glomerulopathy 10.2 CFH CFB
13 enterocolitis 10.2 CFH CFB
14 macular dystrophy, dominant cystoid 10.2 BEST1 ABCA4
15 vitreoretinochoroidopathy 10.2 ELOVL4 BEST1 ABCA4
16 methylmalonic aciduria and homocystinuria, cblc type 10.2 CFH CFB
17 hereditary retinal dystrophy 10.2 ELOVL4 BEST1 ABCA4
18 vitelliform macular dystrophy 10.2 ELOVL4 BEST1 ABCA4
19 bullous retinoschisis 10.2 TYR CFH
20 kuhnt-junius degeneration 10.1 CFH CFB
21 fundus albipunctatus 10.1 ELOVL4 BEST1 ABCA4
22 choroid disease 10.1 BEST1 ABCA4
23 complement component 2 deficiency 10.1 CFH CFB
24 choroiditis 10.1 CFH CFB ABCA4
25 color blindness 10.0 STT3A ABCA4
26 doyne honeycomb retinal dystrophy 10.0 ELOVL4 CFH BEST1 ABCA4
27 cataract 10.0
28 complement deficiency 9.9 CFH CFB
29 basal laminar drusen 9.9 CFH CFB BEST1 ABCA4
30 retinal degeneration 9.8 RAB8A ELOVL4 BEST1 ABCA4
31 achromatopsia 9.8 STT3A SFTA3 BEST1 ABCA4
32 autosomal genetic disease 9.8 TYR CFH ABCA4
33 congenital stationary night blindness 9.8 STT3A SFTA3 BEST1 ABCA4
34 retinal drusen 9.7 ELOVL4 CFH CFB BEST1 ABCA4
35 degeneration of macula and posterior pole 9.7 ELOVL4 CFH CFB BEST1 ABCA4
36 retinal disease 9.7 ELOVL4 CFH CFB BEST1 ABCA4
37 autoimmune disease of skin and connective tissue 9.5 TYR TGM2
38 stargardt disease 9.5 STT3A SFTA3 ELOVL4 CFH BEST1 ABCA4
39 cone-rod dystrophy 2 9.4 TYR STT3A RAB8A BEST1 ABCA4
40 leber plus disease 9.3 STT3A SFTA3 RAB8A ELOVL4 BEST1 ABCA4
41 eye degenerative disease 9.2 STT3A SFTA3 ELOVL4 CFH CFB BEST1
42 eye disease 9.1 TYR SFTA3 CFH CFB BEST1 ABCA4
43 fundus dystrophy 8.5 TYR STT3A SFTA3 RAB8A ELOVL4 CFH
44 retinitis pigmentosa 8.1 TYR STT3A SFTA3 RAB8A NT5M ELOVL4
45 macular degeneration, age-related, 6 7.8 TGM2 SURF4 STT3A SFTA3 ELOVL4 CKAP5

Graphical network of the top 20 diseases related to Macular Degeneration, Age-Related, 4:



Diseases related to Macular Degeneration, Age-Related, 4

Symptoms & Phenotypes for Macular Degeneration, Age-Related, 4

Human phenotypes related to Macular Degeneration, Age-Related, 4:

31
# Description HPO Frequency HPO Source Accession
1 macular degeneration 31 HP:0000608

Clinical features from OMIM:

610698

GenomeRNAi Phenotypes related to Macular Degeneration, Age-Related, 4 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased number of mitotic cells GR00098-A-3 8.8 BEST1 CKAP5 STT3A

MGI Mouse Phenotypes related to Macular Degeneration, Age-Related, 4:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 9.02 ABCA4 BEST1 CFH ELOVL4 TYR

Drugs & Therapeutics for Macular Degeneration, Age-Related, 4

Search Clinical Trials , NIH Clinical Center for Macular Degeneration, Age-Related, 4

Genetic Tests for Macular Degeneration, Age-Related, 4

Genetic tests related to Macular Degeneration, Age-Related, 4:

# Genetic test Affiliating Genes
1 Age-Related Macular Degeneration 4 29 CFH

Anatomical Context for Macular Degeneration, Age-Related, 4

MalaCards organs/tissues related to Macular Degeneration, Age-Related, 4:

40
Eye, Retina, Testes, Endothelial

Publications for Macular Degeneration, Age-Related, 4

Articles related to Macular Degeneration, Age-Related, 4:

(show top 50) (show all 58)
# Title Authors PMID Year
1
Rare complement factor H variant associated with age-related macular degeneration in the Amish. 56 6
24906858 2014
2
A rare penetrant mutation in CFH confers high risk of age-related macular degeneration. 6 56
22019782 2011
3
Independent effects of complement factor H Y402H polymorphism and cigarette smoking on risk of age-related macular degeneration. 6 56
17241667 2007
4
Complement factor H polymorphism p.Tyr402His and cuticular Drusen. 6 56
17210858 2007
5
Population-based study of early age-related macular degeneration: role of the complement factor H Y402H polymorphism in bilateral but not unilateral disease. 6 56
17198853 2007
6
A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration. 6 56
16998489 2006
7
Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration. 56 6
16936732 2006
8
CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration. 6 56
16936733 2006
9
No association between complement factor H gene polymorphism and exudative age-related macular degeneration in Japanese. 56 6
16710702 2006
10
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. 56 6
15870199 2005
11
Complement factor H variant increases the risk of age-related macular degeneration. 56 6
15761120 2005
12
Complement factor H polymorphism and age-related macular degeneration. 6 56
15761121 2005
13
Complement factor H polymorphism in age-related macular degeneration. 56 6
15761122 2005
14
Joint Associations of Diet, Lifestyle, and Genes with Age-Related Macular Degeneration. 56
26354764 2015
15
Phenotypic Characterization of Complement Factor H R1210C Rare Genetic Variant in Age-Related Macular Degeneration. 6
25880396 2015
16
Identification of a rare coding variant in complement 3 associated with age-related macular degeneration. 6
24036949 2013
17
CFH and ARMS2 genetic polymorphisms predict response to antioxidants and zinc in patients with age-related macular degeneration. 6
23972322 2013
18
Seven new loci associated with age-related macular degeneration. 56
23455636 2013
19
Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. 6
21979047 2011
20
Complement regulation at necrotic cell lesions is impaired by the age-related macular degeneration-associated factor-H His402 risk variant. 6
21930971 2011
21
Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population. 6
21909106 2011
22
Reducing the genetic risk of age-related macular degeneration with dietary antioxidants, zinc, and ω-3 fatty acids: the Rotterdam study. 6
21670343 2011
23
An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD). 6
20843825 2010
24
Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina. 6
20660596 2010
25
Associations of CFHR1-CFHR3 deletion and a CFH SNP to age-related macular degeneration are not independent. 56
20581873 2010
26
Multilocus analysis of age-related macular degeneration. 6
19259132 2009
27
Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations. 6
18252712 2008
28
Basal laminar drusen caused by compound heterozygous variants in the CFH gene. 6
18252232 2008
29
Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency. 6
18006700 2008
30
The common Y402H variant in complement factor H gene is not associated with susceptibility to myocardial infarction and its related risk factors. 6
17472578 2007
31
Lack of association between complement factor H polymorphisms and coronary artery disease or myocardial infarction. 6
17396242 2007
32
Genetics of pigment changes and geographic atrophy. 56
17591865 2007
33
Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism. 6
17360715 2007
34
Association of complement factor H Y402H gene polymorphism with different subtypes of exudative age-related macular degeneration. 6
17398321 2007
35
The factor H variant associated with age-related macular degeneration (His-384) and the non-disease-associated form bind differentially to C-reactive protein, fibromodulin, DNA, and necrotic cells. 6
17293598 2007
36
Primary glomerulonephritis with isolated C3 deposits: a new entity which shares common genetic risk factors with haemolytic uraemic syndrome. 6
17018561 2007
37
Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome. 6
17367211 2007
38
A prospective study of 2 major age-related macular degeneration susceptibility alleles and interactions with modifiable risk factors. 56
17210852 2007
39
CFH, ELOVL4, PLEKHA1 and LOC387715 genes and susceptibility to age-related maculopathy: AREDS and CHS cohorts and meta-analyses. 56
17000705 2006
40
Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid. 6
17079491 2006
41
His-384 allotypic variant of factor H associated with age-related macular degeneration has different heparin binding properties from the non-disease-associated form. 6
16787919 2006
42
Complement factor H Y402H gene polymorphism, C-reactive protein, and risk of incident myocardial infarction, ischaemic stroke, and venous thromboembolism: a nested case-control study. 6
16229850 2006
43
Synergic effect of polymorphisms in ERCC6 5' flanking region and complement factor H on age-related macular degeneration predisposition. 56
16754848 2006
44
A common polymorphism in the complement factor H gene is associated with increased risk of myocardial infarction: the Rotterdam Study. 6
16630992 2006
45
CFH gene variant, Y402H, and smoking, body mass index, environmental associations with advanced age-related macular degeneration. 6
16816528 2006
46
Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration. 6
15895326 2005
47
Candidate gene analysis suggests a role for fatty acid biosynthesis and regulation of the complement system in the etiology of age-related maculopathy. 56
15930014 2005
48
Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome. 6
12697737 2003
49
New Frontiers in Retina: highlights of the 2020 angiogenesis, exudation and degeneration symposium. 61
32477592 2020
50
Test performance of optical coherence tomography angiography in detecting retinal diseases: a systematic review and meta-analysis. 61
30971815 2019

Variations for Macular Degeneration, Age-Related, 4

ClinVar genetic disease variations for Macular Degeneration, Age-Related, 4:

6 (show top 50) (show all 87) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CFH NM_000186.3(CFH):c.1204= (p.His402=)SNV Pathogenic,risk factor 16549 rs1061170 1:196659237-196659237 1:196690107-196690107
2 CFH NM_000186.3(CFH):c.1419G>C (p.Ala473=)SNV risk factor 16556 rs2274700 1:196682947-196682947 1:196713817-196713817
3 CFH NM_000186.3(CFH):c.2237-543=SNV risk factor 16557 rs1410996 1:196696933-196696933 1:196727803-196727803
4 CFH NM_000186.3(CFH):c.1507C>G (p.Pro503Ala)SNV risk factor 157562 rs570523689 1:196683035-196683035 1:196713905-196713905
5 CFH NM_000186.3(CFH):c.285T>C (p.Thr95=)SNV Conflicting interpretations of pathogenicity 294482 rs148182625 1:196643027-196643027 1:196673897-196673897
6 CFH NM_000186.3(CFH):c.3310+12T>CSNV Conflicting interpretations of pathogenicity 294524 rs757045842 1:196712770-196712770 1:196743640-196743640
7 CFH NM_000186.3(CFH):c.770G>A (p.Arg257His)SNV Conflicting interpretations of pathogenicity 294487 rs140107330 1:196648903-196648903 1:196679773-196679773
8 CFH NM_000186.3(CFH):c.2196G>A (p.Thr732=)SNV Conflicting interpretations of pathogenicity 294499 rs144325643 1:196696030-196696030 1:196726900-196726900
9 CFH NM_000186.3(CFH):c.3628C>T (p.Arg1210Cys)SNV Conflicting interpretations of pathogenicity 16558 rs121913059 1:196716375-196716375 1:196747245-196747245
10 CFH NM_000186.4(CFH):c.2944C>T (p.Pro982Ser)SNV Conflicting interpretations of pathogenicity 874381 1:196709910-196709910 1:196740780-196740780
11 CFH NM_000186.4(CFH):c.3156C>T (p.Pro1052=)SNV Conflicting interpretations of pathogenicity 875390 1:196712604-196712604 1:196743474-196743474
12 CFH NM_000186.4(CFH):c.245-15T>CSNV Conflicting interpretations of pathogenicity 874979 1:196642972-196642972 1:196673842-196673842
13 CFH NM_000186.4(CFH):c.2596+8G>TSNV Conflicting interpretations of pathogenicity 876153 1:196706144-196706144 1:196737014-196737014
14 CFH NM_000186.4(CFH):c.2956+13G>ASNV Conflicting interpretations of pathogenicity 874382 1:196709935-196709935 1:196740805-196740805
15 CFH NM_000186.4(CFH):c.172T>G (p.Ser58Ala)SNV Conflicting interpretations of pathogenicity 874052 1:196642221-196642221 1:196673091-196673091
16 CFH NM_000186.4(CFH):c.879G>A (p.Gln293=)SNV Conflicting interpretations of pathogenicity 875038 1:196654282-196654282 1:196685152-196685152
17 CFH NM_000186.4(CFH):c.907C>T (p.Arg303Trp)SNV Conflicting interpretations of pathogenicity 875964 1:196654310-196654310 1:196685180-196685180
18 CFH NM_000186.4(CFH):c.1418C>T (p.Ala473Val)SNV Conflicting interpretations of pathogenicity 875087 1:196682946-196682946 1:196713816-196713816
19 CFH NM_000186.3(CFH):c.3133+4C>GSNV Conflicting interpretations of pathogenicity 598661 rs374729595 1:196711185-196711185 1:196742055-196742055
20 CFH NM_000186.4(CFH):c.16A>G (p.Lys6Glu)SNV Conflicting interpretations of pathogenicity 875858 1:196621263-196621263 1:196652133-196652133
21 CFH NM_000186.4(CFH):c.2424A>G (p.Ile808Met)SNV Conflicting interpretations of pathogenicity 875193 1:196705964-196705964 1:196736834-196736834
22 CFH NM_000186.3(CFH):c.2957-7A>GSNV Conflicting interpretations of pathogenicity 294512 rs190778135 1:196710998-196710998 1:196741868-196741868
23 CFH NM_000186.3(CFH):c.3004G>C (p.Gly1002Arg)SNV Conflicting interpretations of pathogenicity 294513 rs201816520 1:196711052-196711052 1:196741922-196741922
24 CFH NM_000186.3(CFH):c.1736T>C (p.Val579Ala)SNV Conflicting interpretations of pathogenicity 294495 rs201411537 1:196694290-196694290 1:196725160-196725160
25 CFH NM_000186.3(CFH):c.2215A>G (p.Thr739Ala)SNV Uncertain significance 294500 rs886045745 1:196696049-196696049 1:196726919-196726919
26 CFH NM_000186.4(CFH):c.2763T>C (p.Ser921=)SNV Uncertain significance 875243 1:196706771-196706771 1:196737641-196737641
27 CFH NM_000186.4(CFH):c.33G>T (p.Met11Ile)SNV Uncertain significance 876852 1:196621280-196621280 1:196652150-196652150
28 CFH NM_000186.3(CFH):c.481G>T (p.Ala161Ser)SNV Uncertain significance 625915 rs777300338 1:196646659-196646659 1:196677529-196677529
29 CFH NM_000186.3(CFH):c.2461C>T (p.His821Tyr)SNV Uncertain significance 625916 rs367687415 1:196706001-196706001 1:196736871-196736871
30 CFH NM_000186.4(CFH):c.7C>G (p.Leu3Val)SNV Uncertain significance 875857 1:196621254-196621254 1:196652124-196652124
31 CFH NM_000186.4(CFH):c.1451C>T (p.Ala484Val)SNV Uncertain significance 876029 1:196682979-196682979 1:196713849-196713849
32 CFH NM_000186.4(CFH):c.1984A>G (p.Arg662Gly)SNV Uncertain significance 875133 1:196695710-196695710 1:196726580-196726580
33 CFH NM_000186.4(CFH):c.2278A>T (p.Ile760Leu)SNV Uncertain significance 874263 1:196697517-196697517 1:196728387-196728387
34 CFH NM_000186.4(CFH):c.2314G>A (p.Asp772Asn)SNV Uncertain significance 874264 1:196697553-196697553 1:196728423-196728423
35 CFH NM_000186.4(CFH):c.3134-5T>CSNV Uncertain significance 875337 1:196712577-196712577 1:196743447-196743447
36 CFH NM_000186.4(CFH):c.3291G>A (p.Thr1097=)SNV Uncertain significance 874522 1:196712739-196712739 1:196743609-196743609
37 CFH NM_000186.4(CFH):c.*127G>TSNV Uncertain significance 873579 1:196716570-196716570 1:196747440-196747440
38 CFH NM_000186.3(CFH):c.-61A>GSNV Uncertain significance 294477 rs886045741 1:196621187-196621187 1:196652057-196652057
39 CFH NM_000186.3(CFH):c.2639C>T (p.Thr880Ile)SNV Uncertain significance 294506 rs186711438 1:196706647-196706647 1:196737517-196737517
40 CFH NM_000186.3(CFH):c.3134-7T>CSNV Uncertain significance 294518 rs779166622 1:196712575-196712575 1:196743445-196743445
41 CFH NM_000186.3(CFH):c.103G>A (p.Gly35Ser)SNV Uncertain significance 294479 rs886045742 1:196642152-196642152 1:196673022-196673022
42 CFH NM_000186.3(CFH):c.2542G>A (p.Gly848Arg)SNV Uncertain significance 294503 rs886045746 1:196706082-196706082 1:196736952-196736952
43 CFH NM_000186.3(CFH):c.2784C>A (p.Gly928=)SNV Uncertain significance 294508 rs755926856 1:196709750-196709750 1:196740620-196740620
44 CFH NM_000186.3(CFH):c.*14G>ASNV Uncertain significance 294527 rs463726 1:196716457-196716457 1:196747327-196747327
45 CFH NM_000186.3(CFH):c.-175T>CSNV Uncertain significance 294474 rs762143457 1:196621073-196621073 1:196651943-196651943
46 CFH NM_000186.3(CFH):c.3028G>A (p.Ala1010Thr)SNV Uncertain significance 451521 rs11539862 1:196711076-196711076 1:196741946-196741946
47 CFH NM_000186.3(CFH):c.275C>T (p.Pro92Leu)SNV Uncertain significance 294481 rs886045743 1:196643017-196643017 1:196673887-196673887
48 CFH NM_000186.3(CFH):c.-79A>GSNV Likely benign 294476 rs35906110 1:196621169-196621169 1:196652039-196652039
49 CFH NM_000186.3(CFH):c.2867C>T (p.Thr956Met)SNV Likely benign 294511 rs145975787 1:196709833-196709833 1:196740703-196740703
50 CFH NM_000186.3(CFH):c.1548T>A (p.Asn516Lys)SNV Likely benign 294493 rs147403664 1:196684751-196684751 1:196715621-196715621

UniProtKB/Swiss-Prot genetic disease variations for Macular Degeneration, Age-Related, 4:

73
# Symbol AA change Variation ID SNP ID
1 CFH p.Arg1210Cys VAR_025885 rs121913059

Expression for Macular Degeneration, Age-Related, 4

Search GEO for disease gene expression data for Macular Degeneration, Age-Related, 4.

Pathways for Macular Degeneration, Age-Related, 4

GO Terms for Macular Degeneration, Age-Related, 4

Biological processes related to Macular Degeneration, Age-Related, 4 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.13 TYR BEST1 ABCA4
2 complement activation, alternative pathway GO:0006957 8.62 CFH CFB

Sources for Macular Degeneration, Age-Related, 4

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