MAFD1
MCID: MJR007
MIFTS: 45

Major Affective Disorder 1 (MAFD1)

Categories: Genetic diseases, Mental diseases

Aliases & Classifications for Major Affective Disorder 1

MalaCards integrated aliases for Major Affective Disorder 1:

Name: Major Affective Disorder 1 58 12 30 13 74
Bipolar Affective Disorder 58 30 6
Bipolar Affective Disorder, Susceptibility to 6
Manic-Depressive Psychosis, Autosomal 58
Bipolar Affective Disorder; Bpad 58
Manic-Depressive Psychosis; Md1 58
Manic-Depressive Psychosis 58
Bipolar Disorder 74
Mafd1 58
Bpad 58
Md1 58

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant


HPO:

33
major affective disorder 1:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:0080220
OMIM 58 125480
ICD10 34 F31
MedGen 43 C1852197

Summaries for Major Affective Disorder 1

MalaCards based summary : Major Affective Disorder 1, also known as bipolar affective disorder, is related to myotonic dystrophy 1 and major affective disorder 4. An important gene associated with Major Affective Disorder 1 is MAFD1 (Major Affective Disorder 1). The drugs Ziprasidone and Lithium carbonate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and heart, and related phenotypes are depressivity and mania

Description from OMIM: 125480

Related Diseases for Major Affective Disorder 1

Diseases in the Major Affective Disorder 1 family:

Major Affective Disorder 2 Major Affective Disorder 3
Major Affective Disorder 4 Major Affective Disorder 5
Major Affective Disorder 6 Major Affective Disorder 8
Major Affective Disorder 7 Major Affective Disorder 9

Diseases related to Major Affective Disorder 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 myotonic dystrophy 1 12.1
2 major affective disorder 4 12.0
3 major affective disorder 5 12.0
4 major affective disorder 6 12.0
5 major affective disorder 2 11.7
6 mental retardation, x-linked, syndromic 13 11.6
7 major affective disorder 3 11.5
8 major affective disorder 7 11.4
9 bipolar disorder 11.4
10 cone-rod dystrophy and hearing loss 2 11.1
11 depression 10.4
12 major affective disorder 8 10.4
13 major affective disorder 9 10.4
14 schizophrenia 10.2
15 neurotic disorder 10.2
16 myotonic dystrophy 10.2
17 myotonia atrophica 10.2
18 tardive dyskinesia 10.2
19 personality disorder 10.2
20 obsessive-compulsive disorder 10.2
21 major depressive disorder 10.2
22 endogenous depression 10.1
23 pfeiffer syndrome 10.1
24 multiple sclerosis 10.1
25 methylmalonic acidemia 10.1
26 disease of mental health 10.1
27 syphilis 10.1
28 tertiary syphilis 10.1
29 appendicitis 10.1
30 thalassemia 10.1
31 dementia 10.1
32 substance abuse 10.1
33 burns 10.1
34 ischemia 10.1
35 frontotemporal dementia 10.0
36 alacrima, achalasia, and mental retardation syndrome 10.0
37 borderline personality disorder 10.0
38 hypothyroidism 10.0
39 mental depression 10.0
40 head injury 10.0
41 autism 9.9
42 orthostatic intolerance 9.9
43 beta-thalassemia 9.9
44 hydrocephalus 9.9
45 conn's syndrome 9.9
46 schizoaffective disorder 9.9
47 adenoma 9.9
48 periodontitis 9.9
49 cyclothymic disorder 9.9
50 learning disability 9.9

Graphical network of the top 20 diseases related to Major Affective Disorder 1:



Diseases related to Major Affective Disorder 1

Symptoms & Phenotypes for Major Affective Disorder 1

Human phenotypes related to Major Affective Disorder 1:

33
# Description HPO Frequency HPO Source Accession
1 depressivity 33 HP:0000716
2 mania 33 HP:0100754

Symptoms via clinical synopsis from OMIM:

58
Neurologic Behavioral Psychiatric Manifestations:
depression with mania (bipolar 1)
depression with hypomania (bipolar 2)

Clinical features from OMIM:

125480

Drugs & Therapeutics for Major Affective Disorder 1

Drugs for Major Affective Disorder 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 519)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ziprasidone Approved Phase 4,Phase 3,Phase 2,Not Applicable 146939-27-7 60854
2
Lithium carbonate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 554-13-2
3
Lamotrigine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 84057-84-1 3878
4
Topiramate Approved Phase 4,Phase 3,Phase 1 97240-79-4 5284627
5
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 99-66-1 3121
6
Risperidone Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 106266-06-2 5073
7
Sertraline Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 79617-96-2 68617
8
Aripiprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 129722-12-9 60795
9
Olanzapine Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 132539-06-1 4585
10
Fluoxetine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 54910-89-3 3386
11
Methylphenidate Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 113-45-1 4158
12
Carbamazepine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 298-46-4 2554
13
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 62-31-7, 51-61-6 681
14
Oxcarbazepine Approved Phase 4,Phase 2,Phase 3 28721-07-5 34312
15
Coal tar Approved Phase 4,Phase 2 8007-45-2
16
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Not Applicable,Early Phase 1 616-91-1 12035
17
Bupropion Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 34841-39-9, 34911-55-2 444
18
Ropinirole Approved, Investigational Phase 4 91374-20-8, 91374-21-9 5095 497540
19
Paroxetine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 61869-08-7 43815
20
Citalopram Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59729-33-8 2771
21
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 6740-88-1 3821
22
Memantine Approved, Investigational Phase 4,Phase 2,Phase 3 19982-08-2 4054
23
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 64-17-5 702
24
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 51-41-2 439260
25
Midazolam Approved, Illicit Phase 4,Phase 1,Phase 2,Early Phase 1,Not Applicable 59467-70-8 4192
26
Succinylcholine Approved Phase 4 306-40-1 5314
27
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 2078-54-8 4943
28
tannic acid Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 1401-55-4
29
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 1994-09-7, 94-09-7 2337
30
Varenicline Approved, Investigational Phase 4,Not Applicable 249296-44-4 5310966
31
Pramipexole Approved, Investigational Phase 4,Phase 2 104632-26-0 119570 59868
32
Nortriptyline Approved Phase 4 72-69-5 4543
33
Modafinil Approved, Investigational Phase 4,Phase 2 68693-11-8 4236
34
Mirtazapine Approved Phase 4 85650-52-8, 61337-67-5 4205
35
Histamine Approved, Investigational Phase 4,Phase 3,Phase 1 51-45-6 774
36
Tranylcypromine Approved, Investigational Phase 4,Not Applicable 155-09-9 441233
37
Asenapine Approved Phase 4,Phase 3,Phase 2,Phase 1 85650-56-2, 65576-45-6 3001386
38
Clozapine Approved Phase 4,Phase 3,Phase 2,Not Applicable 5786-21-0 2818
39
Cocaine Approved, Illicit Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 50-36-2 446220 5760
40
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 16590-41-3 5360515
41
Iloperidone Approved Phase 4,Phase 1 133454-47-4 71360
42
Galantamine Approved Phase 4,Phase 3,Not Applicable 357-70-0 9651
43
Allopurinol Approved Phase 4,Phase 3 315-30-0 2094
44
Promethazine Approved, Investigational Phase 4,Phase 3 60-87-7 4927
45
Suvorexant Approved, Investigational Phase 4 1030377-33-3
46
Diphenhydramine Approved, Investigational Phase 4,Phase 3 147-24-0, 58-73-1 3100
47
Ondansetron Approved Phase 4,Phase 3 99614-02-5 4595
48
Metformin Approved Phase 4,Phase 3 657-24-9 14219 4091
49
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
50
Racepinephrine Approved Phase 4 329-65-7 838

Interventional clinical trials:

(show top 50) (show all 1352)
# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Efficacy and Safety of Flexible Dose of Quetiapine Fumarate (Seroquel) Switching From Other Drugs in the Treatment of Acute Manic Patients With Bipolar Disorder Unknown status NCT00837343 Phase 4 quetiapine fumarate tablet (Seroquel)
2 Juvenile Bipolar Disorder Outpatient Program Unknown status NCT01000402 Phase 4 Psychopharmacotherapy
3 Open Label Study of Lithium Plus Extended-Release Carbamazepine (ERC-CBZ) for Rapid Cycling Bipolar Disorder Unknown status NCT00325286 Phase 4 Lithium Plus Extended- Release Carbamazepine
4 Neurofunctional and Neurochemical Markers of Treatment Response in Bipolar Disorder Unknown status NCT00608075 Phase 4 lithium;Lithium
5 Quetiapine SR and Divalproex Sodium ER in the Treatment of Anxiety in Bipolar Disorder With Panic Disorder and/or GAD Unknown status NCT00579280 Phase 4 quetiapine SR;divalproex sodium ER;placebo
6 Comparative Efficacy and Acceptability of Antimanic Drugs in Acute Mania Unknown status NCT01893229 Phase 4 Lithium;Valproate;Oxcarbazepine;Quetiapine;Olanzapine;Ziprasidone
7 Efficacy of N-Acetyl-Cysteine in Bipolar Disorder and Tobacco Use Disorder Unknown status NCT02252341 Phase 4
8 Using Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Bipolar Depression Unknown status NCT01583023 Phase 4 Bupropion
9 Guidance Model of Standardized Treatment of Antidepressants in Bipolar Disorder Unknown status NCT03148535 Phase 4 Lithium Carbonate;lithium carbonate combined with SSRI antidepressant treatment
10 Reversal of Antipsychotic-Induced Hyperprolactinemia, Weight Gain, Hyperglycemia and Dyslipidemia Unknown status NCT00541554 Phase 4 Abilify (aripiprazole)
11 A Placebo Controlled Trial of the Dopamine D-2 Receptor Agonist Ropinirole in Treatment of 60 Patients With Refractory Bipolar Depression. Unknown status NCT00335205 Phase 4 ropinirole
12 The Effect of Quetiapine XR in Depressive Patients Showing Aberrant N100 Amplitude Slope Unknown status NCT01357967 Phase 4 SSRI monotherapy;Seroquel XR adjunctive
13 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients Unknown status NCT01246310 Phase 4
14 Efficacy and Safety of Utapine vs. Seroquel in Patients With Bipolar Mania Unknown status NCT01043679 Phase 4 Utapine;Seroquel
15 Reduction of Cardiovascular Risk in Severe Mental Illness Unknown status NCT01182012 Phase 4
16 Neurophysiologic Changes in Patients With Bipolar Depression Unknown status NCT01213121 Phase 4 Quetiapine
17 Transcranial Magnetic Stimulation in Bipolar Depression Completed NCT00186758 Phase 4
18 Clinical Utility of Pharmacogenomics of Psychotropic Medications Not yet recruiting NCT03907124 Phase 4 Genetically-guided treatment with FDA-approved psychotropic drugs;Treatment as usual (TAU)
19 Melatonin Versus Placebo for Benzodiazepine Discontinuation in Patients With Schizophrenia Completed NCT01431092 Phase 4 Placebo;Melatonin
20 Psychosocial Therapy Plus Maintenance Pharmacotherapy for Treating Bipolar Disorder Completed NCT00227968 Phase 4
21 Comparison of Propofol Target-Controlled Infusion Anesthesia and Bolus Injection in Electroconvulsive Therapy Completed NCT03863925 Phase 4
22 Comparison of Ketamine Combine Propofol vs Propofol Anesthesia in Schizophrenia Electroconvulsive Therapy Not yet recruiting NCT03829124 Phase 4 Propofol;Ketamine
23 Safety Study of Depakote Versus Lithium in African Americans With Bipolar Disorder Withdrawn NCT01075126 Phase 4 Depakote;Lithium
24 Abilify in Bipolar Disorder for 24 Weeks Treatment Effectiveness Completed NCT00545675 Phase 4 Abilify(aripiprazole);Depakote (divalproate)
25 Effectiveness of Lithium Plus Optimized Medication in Treating People With Bipolar Disorder Completed NCT00667745 Phase 4 Lithium Carbonate;Optimized Treatment (OPT)
26 Varenicline Treatment for Smoking Cessation in Patients With Bipolar Disorder Completed NCT01010204 Phase 4 Varenicline;Placebo
27 Targeting Cognition in Bipolar Disorder With Pramipexole Completed NCT02397837 Phase 4 Pramipexole;Placebo
28 Memantine and Cognitive Dysfunction in Bipolar Disorder Completed NCT00586066 Phase 4 Memantine;Placebo
29 The Efficacy and Safety of Oral Oxcarbazepine 300-1200 mg/Day as Adjuvant Therapy in the Treatment of Bipolar Disorder I or II This Study is Not Being Conducted in the United States. Completed NCT00154323 Phase 4 Oxcarbazepine
30 Paliperidone Palmitate Efficacy and Safety in Bipolar Disorder Complicated by Alcoholism Withdrawn NCT01211704 Phase 4 Paliperidone Palmitate;Placebo
31 Topiramate vs. Placebo in Preventing Weight Gain in Bipolar Disorder Treated With Olanzapine Completed NCT00394095 Phase 4 Topiramate;Placebo
32 Safety And Efficacy Study Of Depakote ER To Treat Pediatric Bipolar Disorder Completed NCT00199966 Phase 4 Divalproex sodium extended release
33 Depakote Monotherapy, Olanzapine Monotherapy, and Combination Therapy of Depakote Plus Olanzapine in Stable Subjects During the Maintenance Phase of Bipolar Illness Terminated NCT00071253 Phase 4 Divalproex Sodium (Delayed-Release Tablets);Divalproex Sodium (Extended-Release Tablets);Olanzapine
34 Olanzapine Compared to Lamotrigine in the Prevention of Depressive Episode in the Patients With Bipolar Disorder Completed NCT01864551 Phase 4 Lamotrigine;Olanzapine
35 Effect of Oxcarbazepine on Serum Brain Derived Neurotrophic Factor (BDNF) in Bipolar Disorder Completed NCT02456896 Phase 4 Oxcarbazepine
36 Cost- Effectiveness and Quality of Life Assessment in Bipolar Disorder Depressive Episode Completed NCT02918097 Phase 4 Lithium Carbonate;Sertraline;Nortriptyline;Risperidone
37 Abilify in Bipolar Disorder for 6 Weeks Treatment Effectiveness Completed NCT00545142 Phase 4 Abilify(Aripiprazole);Depakote(Divalproate)
38 Targeting Circadian and Cognitive Dysfunction in Bipolar Disorder With Modafinil Completed NCT01965925 Phase 4 Modafinil;Placebo
39 Aripiprazole in Late Life Bipolar Disorder Completed NCT00194038 Phase 4 Aripiprazole
40 Comparative Effectiveness Study for Bipolar Disorder Completed NCT01331304 Phase 4 Lithium;Quetiapine
41 Quetiapine for Bipolar Disorder and Alcohol Dependence Completed NCT00457197 Phase 4 Placebo;Quetiapine
42 Treatment of Geriatric Bipolar Mood Disorders: A Pilot Study Completed NCT00177567 Phase 4 lithium carbonate;Depakote-ER;risperidone;olanzapine;paroxetine;bupropion;lamotrigine;venlafaxine;tranylcypromine;mirtazapine
43 Ziprasidone in Pediatric Bipolar Disorder Completed NCT00622739 Phase 4 Ziprasidone;Ziprasidone
44 Asenapine in the Treatment of Older Adults With Bipolar Disorder Completed NCT01460290 Phase 4 Asenapine
45 Quetiapine Fumarate (Seroquel) as Mono-Therapy or Adjunct to Lithium in the Treatment of Patients With Acute Mania in Bipolar Disorder Completed NCT00672490 Phase 4 Quetiapine Fumarate;Lithium
46 Ziprasidone Switching in Response to Adherence and Psychotropic-Related Weight Gain Concerns Among Patients With Bipolar Disorder (Zip Ad) Completed NCT01293825 Phase 4 ziprasidone
47 Clozapine Versus Other Atypical Antipsychotics for Bipolar Disorder Recruiting NCT02562287 Phase 4 Clozapine;Risperidone;Olanzapine;Quetiapine
48 An Open-Label Extension Study Of Lamotrigine In Subjects With Bipolar Disorder Completed NCT00360126 Phase 4 lamotrigine
49 Quetiapine Sr as Adjunctive Treatment In Mixed States of Bipolar Disorder Completed NCT01195363 Phase 4 quetiapine SR;quetiapine sr placebo
50 Cognitive Enhancement in Bipolar Disorder Completed NCT00597896 Phase 4 pramipexole

Search NIH Clinical Center for Major Affective Disorder 1

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Major Affective Disorder 1

Genetic tests related to Major Affective Disorder 1:

# Genetic test Affiliating Genes
1 Major Affective Disorder 1 30
2 Bipolar Affective Disorder 30

Anatomical Context for Major Affective Disorder 1

MalaCards organs/tissues related to Major Affective Disorder 1:

42
Brain, Testes, Heart, Thyroid, Spinal Cord, Cortex, Eye

Publications for Major Affective Disorder 1

Articles related to Major Affective Disorder 1:

(show top 50) (show all 790)
# Title Authors Year
1
Bipolar affective disorder and borderline personality disorder: Differentiation based on the history of early life stress and psychoneuroendocrine measures. ( 29702176 )
2019
2
Comments on "Stressful Life Events and Relapse in Bipolar Affective Disorder". ( 30983677 )
2019
3
Stressful Life Events and Relapse in Bipolar Affective Disorder: A Cross-Sectional Study from a Tertiary Care Center of Southern India. ( 30783310 )
2019
4
Predominant Polarity in Bipolar Affective Disorder: A Scoping Review of Its Relationship with Clinical Variables and Its Implications. ( 30783303 )
2019
5
A case report of cholinergic rebound syndrome following abrupt low-dose clozapine discontinuation in a patient with type I bipolar affective disorder. ( 30782143 )
2019
6
Clinical Practice Guidelines for Bipolar Affective Disorder (BPAD) in Children and Adolescents. ( 30745704 )
2019
7
Working Memory in Patients with Schizophrenia and Bipolar Affective Disorder: Quantitative or Qualitative Differences? ( 30948690 )
2019
8
Add-on HD-tDCS for obsessive-compulsive disorder with comorbid bipolar affective disorder: A case series. ( 31108398 )
2019
9
Hormonal imbalance and pituitary adenoma during antipsychotic treatment in an adolescent with bipolar affective disorder. ( 30760936 )
2019
10
A gene co-expression module implicating the mitochondrial electron transport chain is associated with long-term response to lithium treatment in bipolar affective disorder. ( 30185780 )
2018
11
Neuropsychological Functioning in Euthymic Phase of Bipolar Affective Disorder. ( 29875527 )
2018
12
Managing Bipolar Affective Disorder in a Tribal District of Odisha. ( 29875526 )
2018
13
Bipolar Affective Disorder in a Patient of Profound Deafness. ( 29482712 )
2018
14
Assessing Caregiver Burden in Caregivers of Patients with Schizophrenia and Bipolar Affective Disorder in Kathmandu Medical College. ( 29353899 )
2018
15
Effectiveness of Mindfulness-based Cognitive Therapy in Patients with Bipolar Affective Disorder: A Case Series. ( 29343935 )
2018
16
Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study. ( 29121268 )
2018
17
Polydipsia as a Precursor of Manic Episode in Bipolar Affective Disorder Patients with Alcohol Use Disorder. ( 29397674 )
2018
18
Lithium-induced Thyroiditis in a Patient Having Bipolar Affective Disorder - A Rare Case Report. ( 30533956 )
2018
19
Functional magnetic resonance spectroscopy in patients with schizophrenia and bipolar affective disorder: Glutamate dynamics in the anterior cingulate cortex during a working memory task. ( 30558824 )
2018
20
Polycystic Ovary Syndrome in Bipolar Affective Disorder: A Hospital-based Study. ( 29962567 )
2018
21
Corrigendum to "Analysis of association between common SNPs in ErbB4 and bipolar affective disorder, major depressive disorder and schizophrenia in the Han Chinese population" [Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 36 (2012) 17-21]. ( 28803680 )
2018
22
Novel functional variants at the GWAS-implicated loci might confer risk to major depressive disorder, bipolar affective disorder and schizophrenia. ( 29745862 )
2018
23
Lithium-induced Symptomatic Hypercalcemia and Hyperparathyroidism in a Patient with Bipolar Affective Disorder: A Case Report and Review of Literature. ( 30093752 )
2018
24
Bipolar affective disorder and its impact on various aspects of marital relationship. ( 30089956 )
2017
25
Positive Aspects of Caregiving and Its Correlates among Caregivers of Bipolar Affective Disorder. ( 29259143 )
2017
26
Prevalence and Sociodemographic Profile of Lithium-induced Cutaneous Side Effects in Bipolar Affective Disorder Patients: A 1-year Prospective Observational Study in South India. ( 29200562 )
2017
27
Impact of Pharmacist-Psychiatrist Collaborative Patient Education on Medication Adherence and Quality of Life (QOL) of Bipolar Affective Disorder (BPAD) Patients. ( 29066976 )
2017
28
A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia. ( 29049482 )
2017
29
High-dose levothyroxine for the management of bipolar affective disorder: two case reports. ( 28904805 )
2017
30
Schizophrenia and Bipolar Affective Disorder: a Dimensional Approach. ( 28636571 )
2017
31
Bipolar affective disorder and childhood adversity: possible genetic links? ( 28465388 )
2017
32
The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment. ( 28289283 )
2017
33
Adverse events associated with mood stabiliser treatment should be continuously monitored in patients diagnosed with bipolar affective disorder. ( 28254753 )
2017
34
Predictors of rehospitalization in a naturalistic cohort of patients with bipolar affective disorder. ( 28207568 )
2017
35
Identification of rare nonsynonymous variants in SYNE1/CPG2 in bipolar affective disorder. ( 28178086 )
2017
36
Outcomes of Renal Transplantation in Patients With Bipolar Affective Disorder and Schizophrenia: A National Retrospective Cohort Study. ( 27887740 )
2017
37
A Rare Presentation of a Case of Obsessive-compulsive Disorder Comorbid with Bipolar Affective Disorder. ( 29284814 )
2017
38
The temperament and character traits in patients with major depressive disorder and bipolar affective disorder with and without suicide attempt. ( 28636575 )
2017
39
Selective impairment of global motion integration, but not global form detection, in schizophrenia and bipolar affective disorder. ( 28740802 )
2016
40
Distressing cutaneous lesion among bipolar affective disorder patients on lithium therapy: A retrospective cross-sectional study. ( 28196994 )
2016
41
CASE-REPORT Case study of a patient presenting both type II bipolar affective disorder and Klinefelter syndrome. ( 27813593 )
2016
42
Relationship between childhood adversity and bipolar affective disorder: systematic review and meta-analysis. ( 27758835 )
2016
43
Hospital treatment, mortality and healthcare costs in relation to socioeconomic status among people with bipolar affective disorder. ( 27703748 )
2016
44
Are SSRIs responsible for precipitating suicidal ideation in teenagers with 'subsyndromal' bipolar affective disorder who have been misdiagnosed with unipolar depression? ( 27663811 )
2016
45
Disability and Quality of Life of Subjects with Bipolar Affective Disorder in Remission. ( 27570346 )
2016
46
DGKH genetic risk variant influences gene expression in bipolar affective disorder. ( 27016658 )
2016
47
Can Psychological, Social and Demographical Factors Predict Clinical Characteristics Symptomatology of Bipolar Affective Disorder and Schizophrenia? ( 26646576 )
2016
48
Abnormal early brain responses during visual search are evident in schizophrenia but not bipolar affective disorder. ( 26603466 )
2016
49
Cardiac (123)I-meta-iodo-benzyl-guanine in a patient with bipolar affective disorder, musical hallucinations and Parkinsonism. ( 26346109 )
2016
50
Frontotemporal dementia mimicking bipolar affective disorder, normal pressure hydrocephalus and Klüver-Bucy syndrome. ( 26482719 )
2015

Variations for Major Affective Disorder 1

ClinVar genetic disease variations for Major Affective Disorder 1:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TPH2 NM_173353.3(TPH2): c.616C> T (p.Pro206Ser) single nucleotide variant risk factor rs17110563 GRCh37 Chromosome 12, 72366306: 72366306
2 TPH2 NM_173353.3(TPH2): c.616C> T (p.Pro206Ser) single nucleotide variant risk factor rs17110563 GRCh38 Chromosome 12, 71972526: 71972526
3 46;X;inv(X)(q27q28) inversion Uncertain significance
4 CLCN2 NM_004366.5(CLCN2): c.740G> T (p.Gly247Val) single nucleotide variant Uncertain significance rs1553856477 GRCh37 Chromosome 3, 184075440: 184075440
5 CLCN2 NM_004366.5(CLCN2): c.740G> T (p.Gly247Val) single nucleotide variant Uncertain significance rs1553856477 GRCh38 Chromosome 3, 184357652: 184357652

Expression for Major Affective Disorder 1

Search GEO for disease gene expression data for Major Affective Disorder 1.

Pathways for Major Affective Disorder 1

GO Terms for Major Affective Disorder 1

Sources for Major Affective Disorder 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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