MD1
MCID: MJR007
MIFTS: 36

Major Affective Disorder 1 (MD1)

Categories: Mental diseases, Genetic diseases

Aliases & Classifications for Major Affective Disorder 1

MalaCards integrated aliases for Major Affective Disorder 1:

Name: Major Affective Disorder 1 57 12 29 13 73
Bipolar Affective Disorder, Susceptibility to 6
Manic-Depressive Psychosis, Autosomal 57
Bipolar Affective Disorder; Bpad 57
Manic-Depressive Psychosis; Md1 57
Manic-Depressive Psychosis 57
Bipolar Affective Disorder 57
Bipolar Disorder 73
Mafd1 57
Bpad 57
Md1 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
major affective disorder 1:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 125480
Disease Ontology 12 DOID:0080220
MedGen 42 C1852197
UMLS 73 C1852197

Summaries for Major Affective Disorder 1

MalaCards based summary : Major Affective Disorder 1, also known as bipolar affective disorder, susceptibility to, is related to bipolar disorder and myotonic dystrophy 1. An important gene associated with Major Affective Disorder 1 is SLC6A3 (Solute Carrier Family 6 Member 3), and among its related pathways/superpathways is Monoamine Transport. The drugs Valproic Acid and Melatonin have been mentioned in the context of this disorder. Affiliated tissues include bone and myeloid, and related phenotypes are depressivity and mania

Description from OMIM: 125480

Related Diseases for Major Affective Disorder 1

Graphical network of the top 20 diseases related to Major Affective Disorder 1:



Diseases related to Major Affective Disorder 1

Symptoms & Phenotypes for Major Affective Disorder 1

Symptoms via clinical synopsis from OMIM:

57
Neurologic Behavioral Psychiatric Manifestations:
depression with mania (bipolar 1)
depression with hypomania (bipolar 2)


Clinical features from OMIM:

125480

Human phenotypes related to Major Affective Disorder 1:

32
# Description HPO Frequency HPO Source Accession
1 depressivity 32 HP:0000716
2 mania 32 HP:0100754

MGI Mouse Phenotypes related to Major Affective Disorder 1:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 taste/olfaction MP:0005394 8.62 SLC6A3 TPH2

Drugs & Therapeutics for Major Affective Disorder 1

Drugs for Major Affective Disorder 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 92)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Valproic Acid Approved, Investigational Phase 4,Phase 3 99-66-1 3121
2
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
3 Antipsychotic Agents Phase 4,Phase 3
4 Central Nervous System Depressants Phase 4,Phase 3
5 Psychotropic Drugs Phase 4,Phase 3,Phase 1,Phase 2
6 Quetiapine Fumarate Phase 4,Phase 3 111974-72-2
7 Tranquilizing Agents Phase 4,Phase 3
8 Anticonvulsants Phase 4,Phase 3,Phase 2
9 Antidepressive Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
10 Antimanic Agents Phase 4,Phase 3
11 GABA Agents Phase 4,Phase 3
12 Lithium carbonate Phase 4,Phase 3 554-13-2
13 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2
14 Antioxidants Phase 4
15 Protective Agents Phase 4,Phase 3,Phase 2
16
Zolpidem Approved Phase 3 82626-48-0 5732
17
Nitrazepam Approved Phase 3 146-22-5 4506
18
Lamotrigine Approved, Investigational Phase 3 84057-84-1 3878
19
Dopamine Approved Phase 3,Phase 1,Phase 2 51-61-6, 62-31-7 681
20
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
21
Topiramate Approved Phase 3 97240-79-4 5284627
22 GABA Agonists Phase 3
23 GABA-A Receptor Agonists Phase 3
24 Hypnotics and Sedatives Phase 3
25 Anti-Anxiety Agents Phase 3
26 GABA Modulators Phase 3
27 calcium channel blockers Phase 3
28 Calcium, Dietary Phase 3
29 Diuretics, Potassium Sparing Phase 3
30 Excitatory Amino Acid Antagonists Phase 3,Phase 2
31 Excitatory Amino Acids Phase 3,Phase 2
32 Sodium Channel Blockers Phase 3
33 Central Nervous System Stimulants Phase 3
34 Dopamine Agents Phase 3,Phase 1,Phase 2
35 Dopamine Uptake Inhibitors Phase 3,Phase 1,Phase 2
36 Neurotransmitter Uptake Inhibitors Phase 3,Phase 1,Phase 2
37 Anti-Obesity Agents Phase 3
38 Neuroprotective Agents Phase 3,Phase 2
39 Dopamine Antagonists Phase 3
40 Dopamine D2 Receptor Antagonists Phase 3
41 Paliperidone Palmitate Phase 3
42 Serotonin 5-HT2 Receptor Antagonists Phase 3
43 Serotonin Agents Phase 3
44 Serotonin Antagonists Phase 3
45
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
46
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
47
Tamoxifen Approved Phase 2 10540-29-1 2733526
48
Bupropion Approved Phase 1, Phase 2 34841-39-9, 34911-55-2 444
49
Nicotine Approved Phase 1, Phase 2 54-11-5 942 89594
50
Riluzole Approved, Investigational Phase 2 1744-22-5 5070

Interventional clinical trials:

(show top 50) (show all 56)
# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Efficacy and Safety of Flexible Dose of Quetiapine Fumarate (Seroquel) Switching From Other Drugs in the Treatment of Acute Manic Patients With Bipolar Disorder Unknown status NCT00837343 Phase 4 quetiapine fumarate tablet (Seroquel)
2 Transcranial Magnetic Stimulation in Bipolar Depression Completed NCT00186758 Phase 4
3 Melatonin Versus Placebo for Benzodiazepine Discontinuation in Patients With Schizophrenia Completed NCT01431092 Phase 4 Placebo;Melatonin
4 Psychosocial Therapy Plus Maintenance Pharmacotherapy for Treating Bipolar Disorder Completed NCT00227968 Phase 4
5 Safety Study of Depakote Versus Lithium in African Americans With Bipolar Disorder Withdrawn NCT01075126 Phase 4 Depakote;Lithium
6 A Study of FK199B to Compare Efficacy With Zolpidem by Polysomnography in Patients With Insomnia Completed NCT00999219 Phase 3 FK199B;Zolpidem
7 A Double-blind, Group-comparison P-III Study With Zolpidem MR Using Placebo and Nitrazepam in Insomnia Patients Completed NCT00374777 Phase 3 zolpidem MR;nitrazepam;placebo
8 Prophylactic Effect of Lamotrigine Compared With Lithium in Bipolar Disorder Completed NCT00226135 Phase 3 lithium or lamotrigine
9 Methylphenidate for the Treatment of Acute Mania Completed NCT01541605 Phase 3 methylphenidate;Placebo
10 Phase III/Seroquel SR Bipolar Depression Monotherapy - US Completed NCT00422214 Phase 3 Quetiapine fumarate (Seroquel) SR
11 Phase 3 /Seroquel SR Acute Mania Monotherapy - US Completed NCT00422123 Phase 3 Quetiapine fumarate (Seroquel) SR
12 A Study of the Effectiveness and Safety of Topiramate in the Treatment of Patients With Bipolar Disorder Completed NCT00240721 Phase 3 topiramate
13 A Study to Evaluate the Efficacy and Safety of Adjustable Doses of Extended-release (ER) Paliperidone Compared With Placebo, in Combination With Lithium or Valproate, to Treat Manic and Mixed Episodes in Patients With Bipolar I Disorder Completed NCT00309686 Phase 3 Paliperidone ER
14 A Study to Evaluate the Efficacy and Safety of Flexible Doses of Extended-release (ER) Paliperidone Compared With Flexible Doses of Quetiapine and Placebo in Patients With Bipolar I Disorder Completed NCT00309699 Phase 3 Placebo;Quetiapine;Paliperidone ER
15 Cannabidiol as an Adjunctive Treatment for Bipolar Depression Recruiting NCT03310593 Phase 2, Phase 3 Cannabidiol;Placebo
16 rTMS in the Treatment of Bipolar Depression Unknown status NCT00436020 Phase 2
17 Anti-Estrogens - A Potential Treatment for Bipolar Affective Disorder in Women? Completed NCT00206544 Phase 2 Tamoxifen;Progesterone
18 A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Affective Disorder Completed NCT00593099 Phase 1, Phase 2 Bupropion;Placebo
19 Safety and Efficacy Study of Glyco pMDI After Single and Repeated Administration Completed NCT01176903 Phase 1, Phase 2 Glycopyrrolate;Tiotropium;placebo
20 Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar Disorder Terminated NCT00805493 Phase 2 Riluzole
21 Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder Withdrawn NCT00327756 Phase 2 Coenzyme Q10
22 Far Infrared Radiation Treatment for Bipolar Condition Unknown status NCT00573196 Phase 1
23 A Phase I Study of AK159 in Healthy Postmenopausal Women Completed NCT01935479 Phase 1 AK159;MN-10-T;Placebo
24 Clinical Study of AK159 in Healthy Postmenopausal Women Completed NCT01551602 Phase 1 AK159;MN-10-T;Placebo
25 First-in-man Trial of NNC0142-0002 in Patients With Rheumatoid Arthritis Completed NCT00927927 Phase 1 NNC0142-0002;NNC0142-0002;NNC0142-0002;NNC0142-0002;NNC0142-0002;NNC0142-0002;NNC0142-0002;NNC0142-0002;placebo;NNC0142-0002;NNC0142-0002;NNC0142-0002;NNC0142-0002;NNC0142-0002;placebo
26 Dose Finding Study Evaluating Safety and Feasibility in Patients With Relapsed or Refractory Myeloid Neoplasms Recruiting NCT02743611 Phase 1 Rimiducid
27 Myths About Bipolar Affective Disorder: The Role of Structured Group Psychoeducation Therapy Unknown status NCT00474357 Not Applicable
28 Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder (PGBD) Unknown status NCT01272531 Mood stabilizer treatment
29 Neurophysiologic Correlates of Hypersomnia Unknown status NCT01719315
30 A Study of the Association Between Tobacco Smoking and Bipolar Affective Disorder Completed NCT00741299
31 Exercise for Depression Completed NCT02874833 Not Applicable
32 Bipolar Research Study Using MR Imaging Completed NCT02083978
33 Specialized Clozapine Clinic for Bipolar and Schizoaffective Disorder Completed NCT00683709
34 Bipolar Intervention Study: Cognitive Interpersonal Therapy Completed NCT01315028 Not Applicable
35 Postural Spirometry Changes in Ambulatory Myotonic Dystrophy Patients Completed NCT01242007 Not Applicable
36 Genetic Aspects of Neurologic and Psychiatric Disorders Completed NCT00001544
37 Early Integrated Intervention in Severe Affective Disorders Completed NCT00253071 Not Applicable
38 Non-interventional Study of Ziprasidone in the Treatment of Bipolar and Schizoaffective Disorders. Completed NCT00454883 ziprasidone
39 Understanding Treatment Adherence Among Individuals With Rapid Cycling Bipolar Disorder Completed NCT00183703
40 Understanding Treatment Adherence Among Individuals With Bipolar Disorder Completed NCT00183495
41 The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels Completed NCT01385709
42 Blister Packaging Medication to Increase Treatment Adherence and Clinical Response Completed NCT01118208 Not Applicable
43 Transcranial Direct Current Stimulation Apparatus for Domiciliary Use Completed NCT02408237 Not Applicable
44 Cognitive Effects of Music and Dance Training in Children Completed NCT03160391 Not Applicable
45 Amsterdam Stool Scale: Usefulness in Clinical Setting Completed NCT02252718
46 European Comparative Effectiveness Research on Internet-based Depression Treatment Completed NCT02542891 Not Applicable
47 Study of the Psychological Development of Children of Parents With and Without Affective Disorders Completed NCT00001170
48 Study of Sensorimotor Compatibility Effects in Bipolar Affective Disorder. Recruiting NCT03249857 Not Applicable
49 Evaluation of an App for Smartphones for People With a Bipolar Affective Disorder Recruiting NCT03275714 Not Applicable
50 Home-based Transcranial Direct Current Stimulation in Fibromyalgia Patients Recruiting NCT02652988 Not Applicable

Search NIH Clinical Center for Major Affective Disorder 1

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Major Affective Disorder 1

Genetic tests related to Major Affective Disorder 1:

# Genetic test Affiliating Genes
1 Major Affective Disorder 1 29 SLC6A3

Anatomical Context for Major Affective Disorder 1

MalaCards organs/tissues related to Major Affective Disorder 1:

41
Bone, Myeloid

Publications for Major Affective Disorder 1

Articles related to Major Affective Disorder 1:

(show all 11)
# Title Authors Year
1
[Manic-depressive psychosis as prevalent manifestation of multiple sclerosis]. ( 18555881 )
2008
2
[Is there a correlation between cosmophysical factors and emergence of manic-depressive psychosis?]. ( 8555285 )
1995
3
[Combined treatment with lithium salts and socioenvironmental therapy in patients with manic depressive psychosis. Considerations on the results obtained in 1984-88 at the Mental Health Service of Local Health Unit No. 32 in Moncalieri]. ( 2607935 )
1989
4
Tertiary syphilis presenting as manic depressive psychosis. ( 21927396 )
1989
5
[Dynamics of the lipid peroxidation process in the body of patients with manic-depressive psychosis]. ( 3414253 )
1988
6
Short-cycle manic-depressive psychosis in a mentally handicapped child without family history. A case report. ( 3447676 )
1987
7
[Features of the reaction of the rat to intraventricular administration of the cerebrospinal fluid of patients with manic-depressive psychosis]. ( 4050117 )
1985
8
Erythrocyte membrane cation carrier in manic-depressive psychosis. ( 6255506 )
1980
9
Mixed affective states and the natural history of manic-depressive psychosis. ( 427331 )
1979
10
[Modifications of lymphocyte HL-A antigens as a consequence of therapy in patients with manic-depressive psychosis]. ( 83272 )
1978
11
[Uptake of tryptophan and tyrosine in some cases of manic depressive psychosis and schizophrenia (author's transl)]. ( 619304 )
1978

Variations for Major Affective Disorder 1

ClinVar genetic disease variations for Major Affective Disorder 1:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TPH2 NM_173353.3(TPH2): c.616C> T (p.Pro206Ser) single nucleotide variant risk factor rs17110563 GRCh37 Chromosome 12, 72366306: 72366306
2 TPH2 NM_173353.3(TPH2): c.616C> T (p.Pro206Ser) single nucleotide variant risk factor rs17110563 GRCh38 Chromosome 12, 71972526: 71972526

Expression for Major Affective Disorder 1

Search GEO for disease gene expression data for Major Affective Disorder 1.

Pathways for Major Affective Disorder 1

Pathways related to Major Affective Disorder 1 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.26 SLC6A3 TPH2

GO Terms for Major Affective Disorder 1

Cellular components related to Major Affective Disorder 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 8.62 SLC6A3 TPH2

Sources for Major Affective Disorder 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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