MAFD1
MCID: MJR007
MIFTS: 44

Major Affective Disorder 1 (MAFD1)

Categories: Genetic diseases, Mental diseases

Aliases & Classifications for Major Affective Disorder 1

MalaCards integrated aliases for Major Affective Disorder 1:

Name: Major Affective Disorder 1 57 12 29 13 72
Bipolar Affective Disorder 57 29 6 33
Bipolar Affective Disorder, Susceptibility to 6
Manic-Depressive Psychosis, Autosomal 57
Bipolar Affective Disorder; Bpad 57
Manic-Depressive Psychosis; Md1 57
Manic-Depressive Psychosis 57
Bipolar Disorder 72
Mafd1 57
Bpad 57
Md1 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
major affective disorder 1:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:0080220
OMIM 57 125480
ICD10 33 F31 F31.9
MedGen 42 C1852197
UMLS 72 C0005586 C1852197

Summaries for Major Affective Disorder 1

MalaCards based summary : Major Affective Disorder 1, also known as bipolar affective disorder, is related to major affective disorder 2 and major affective disorder 5. An important gene associated with Major Affective Disorder 1 is MAFD1 (Major Affective Disorder 1). The drugs Paroxetine and Reboxetine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related phenotypes are depressivity and mania

More information from OMIM: 125480

Related Diseases for Major Affective Disorder 1

Diseases in the Major Affective Disorder 1 family:

Major Affective Disorder 2 Major Affective Disorder 3
Major Affective Disorder 4 Major Affective Disorder 5
Major Affective Disorder 6 Major Affective Disorder 8
Major Affective Disorder 7 Major Affective Disorder 9

Diseases related to Major Affective Disorder 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 210)
# Related Disease Score Top Affiliating Genes
1 major affective disorder 2 12.2
2 major affective disorder 5 12.1
3 major affective disorder 6 12.1
4 myotonic dystrophy 1 12.1
5 major affective disorder 4 11.8
6 mental retardation, x-linked, syndromic 13 11.7
7 major affective disorder 3 11.6
8 major affective disorder 7 11.5
9 bipolar disorder 11.5
10 schizophrenia 10.6
11 depression 10.6
12 bipolar i disorder 10.4
13 major affective disorder 8 10.4
14 major affective disorder 9 10.4
15 mental depression 10.4
16 major depressive disorder 10.4
17 neurotic disorder 10.3
18 myopathy 10.3
19 myotonic dystrophy 10.3
20 myotonia atrophica 10.3
21 dysphagia 10.3
22 personality disorder 10.3
23 schizoaffective disorder 10.3
24 alcohol dependence 10.3
25 tardive dyskinesia 10.3
26 obsessive-compulsive disorder 10.3
27 yemenite deaf-blind hypopigmentation syndrome 10.3
28 depersonalization disorder 10.3
29 psychotic disorder 10.3
30 melancholia 10.3
31 mood disorder 10.3
32 hypothyroidism 10.2
33 substance abuse 10.2
34 glucose intolerance 10.2
35 ischemia 10.2
36 cyclothymic disorder 10.2
37 huntington disease 10.1
38 attention deficit-hyperactivity disorder 10.1
39 mental health wellness 1 10.1
40 mental health wellness 2 10.1
41 severe combined immunodeficiency 10.1
42 pfeiffer syndrome 10.1
43 multiple sclerosis 10.1
44 hand skill, relative 10.1
45 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
46 asthma 10.1
47 anxiety 10.1
48 aphasia 10.1
49 hypogonadotropic hypogonadism 10.1
50 sexual sadism 10.1

Graphical network of the top 20 diseases related to Major Affective Disorder 1:



Diseases related to Major Affective Disorder 1

Symptoms & Phenotypes for Major Affective Disorder 1

Human phenotypes related to Major Affective Disorder 1:

32
# Description HPO Frequency HPO Source Accession
1 depressivity 32 HP:0000716
2 mania 32 HP:0100754

Symptoms via clinical synopsis from OMIM:

57
Neurologic Behavioral Psychiatric Manifestations:
depression with mania (bipolar 1)
depression with hypomania (bipolar 2)

Clinical features from OMIM:

125480

Drugs & Therapeutics for Major Affective Disorder 1

Drugs for Major Affective Disorder 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 457)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
2
Reboxetine Approved, Experimental Phase 4 98769-81-4, 71620-89-8 123628 65856
3
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
4
Galantamine Approved Phase 4 357-70-0 9651
5
Ropinirole Approved, Investigational Phase 4 91374-21-9, 91374-20-8 5095 497540
6
Memantine Approved, Investigational Phase 4 19982-08-2 4054
7
Topiramate Approved Phase 4 97240-79-4 5284627
8
Tranylcypromine Approved, Investigational Phase 4 155-09-9 441233
9
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
10
Cocaine Approved, Illicit Phase 4 50-36-2 446220 5760
11
Acamprosate Approved, Investigational Phase 4 77337-76-9 71158
12
Levetiracetam Approved, Investigational Phase 4 102767-28-2 441341
13
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
14
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
15
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
16
Norepinephrine Approved Phase 4 51-41-2 439260
17
Sertraline Approved Phase 4 79617-96-2 68617
18
Nortriptyline Approved Phase 4 72-69-5 4543
19
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
20
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
21
Mirtazapine Approved Phase 4 61337-67-5, 85650-52-8 4205
22
Histamine Approved, Investigational Phase 4 51-45-6 774
23
Ondansetron Approved Phase 4 99614-02-5 4595
24
Iloperidone Approved Phase 4 133454-47-4 71360
25
Brexpiprazole Approved, Investigational Phase 4 913611-97-9 11978813
26
Methohexital Approved Phase 4 151-83-7 9034
27
Dipyridamole Approved Phase 4 58-32-2 3108
28
Chlorpromazine Approved, Investigational, Vet_approved Phase 4 50-53-3 2726
29
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
30
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
31
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
32
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
33
Metformin Approved Phase 4 657-24-9 4091 14219
34
Racepinephrine Approved Phase 4 329-65-7 838
35
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
36
Simvastatin Approved Phase 4 79902-63-9 54454
37
Methylcobalamin Approved, Experimental, Investigational Phase 4 13422-55-4
38
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 15589840
39
Amphetamine Approved, Illicit, Investigational Phase 4 300-62-9 5826 3007
40
Dextroamphetamine Approved, Illicit Phase 4 51-64-9 5826
41
Acetaminophen Approved Phase 4 103-90-2 1983
42
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198
43
Losartan Approved Phase 4 114798-26-4 3961
44
Loxapine Approved Phase 4 1977-10-2 3964
45
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
46
Eleuthero Approved, Experimental Phase 4
47
Oxcarbazepine Approved Phase 4 28721-07-5 34312
48
Promethazine Approved, Investigational Phase 4 60-87-7 4927
49
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
50
Clozapine Approved Phase 4 5786-21-0 2818

Interventional clinical trials:

(show top 50) (show all 1440)
# Name Status NCT ID Phase Drugs
1 An Open Label, Multicenter, Single Arm, 4-Week Study to Evaluate the Efficacy and Safety of Flexible Dose of Quetiapine Fumarate (Seroquel) Switching From Other Drugs in the Treatment of Acute Manic Patients With Bipolar Disorder Unknown status NCT00837343 Phase 4 quetiapine fumarate tablet (Seroquel)
2 Effects of N-Acetyl-Cysteine on Oxidative Stress Biomarkers in Bipolar Patients With and Without Tobacco Use Disorder Unknown status NCT02252341 Phase 4
3 Neurofunctional and Neurochemical Markers of Treatment Response in Bipolar Disorder Unknown status NCT00608075 Phase 4 lithium;Lithium
4 Exploring Alterations of Central Autonomic Modulation in Patients With Bipolar Depression Unknown status NCT01213121 Phase 4 Quetiapine
5 A Randomized, Double-blind, Placebo-controlled Study of Quetiapine SR and Divalproex Sodium ER on Anxiety in Bipolar Disorder With at Least Moderately Severe Current Anxiety and Lifetime Panic or Generalized Anxiety Disorder. Unknown status NCT00579280 Phase 4 quetiapine SR;divalproex sodium ER;placebo
6 Assessing the Efficacy of Left Repetitive Transcranial Magnetic Stimulation (rTMS) as an Adjunctive Treatment to Mood Stabilizers for the Treatment of Bipolar Depression Unknown status NCT01583023 Phase 4 Bupropion
7 Assessment and Follow Up Study of Children and Adolescent With Bipolar Disorder Unknown status NCT01000402 Phase 4 Psychopharmacotherapy
8 A Placebo Controlled Trial of the Dopamine D-2 Receptor Agonist Ropinirole in Treatment of 60 Patients With Refractory Bipolar I and II Depression. Unknown status NCT00335205 Phase 4 ropinirole
9 Clinical Psychopharmacology Division Institute of Mental Health, Peking University Unknown status NCT03148535 Phase 4 Lithium Carbonate;lithium carbonate combined with SSRI antidepressant treatment
10 A Randomized Open-label Active-controlled Study to Evaluate the Efficacy and Safety of Utapine Versus Seroquel in Patients With Bipolar Mania Unknown status NCT01043679 Phase 4 Utapine;Seroquel
11 Comparative Efficacy and Acceptability of Lithium, Valproate, Oxcarbazepine, Quetiapine, Olanzapine, and Ziprasidone in Bipolar I Disorder, Manic or Mixed Phase Unknown status NCT01893229 Phase 4 Lithium;Valproate;Oxcarbazepine;Quetiapine;Olanzapine;Ziprasidone
12 Open Label Prophylaxis Study of Lithium Plus Extended- Release Carbamazepine (Equetro®) Combination for Rapid Cycling Bipolar Disorder Unknown status NCT00325286 Phase 4 Lithium Plus Extended- Release Carbamazepine
13 Reduction of Cardiovascular Risk in Severe Mental Illness Prescribing and Using Better and More Appropriated Drugs Unknown status NCT01182012 Phase 4
14 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in PCOS Patients. Unknown status NCT01246310 Phase 4
15 Reversal of Antipsychotic-Induced Hyperprolactinemia, Weight Gain, Hyperglycemia and Dyslipidemia by Aripiprazole Add-on Therapy in the Treatment of Schizophrenia and Bipolar Disorder: An Open-Label Trial Unknown status NCT00541554 Phase 4 Abilify (aripiprazole)
16 Phase 3 Reboxetine Treatment in Depressed Children and Adolescents an 8-Week, Open Study Unknown status NCT00426946 Phase 4 Reboxetine
17 The Effect of Quetiapine XR in Depressive Patients Showing Aberrant N100 Amplitude Slope Unknown status NCT01357967 Phase 4 SSRI monotherapy;Seroquel XR adjunctive
18 Maintenance Therapies in Bipolar Disorder Completed NCT00227968 Phase 4
19 A Randomized, Sham Controlled, Crossover Trial of rTMS for Bipolar Depression Completed NCT00186758 Phase 4
20 Comparison of Propofol Target-Controlled Infusion Anesthesia and Bolus Injection in Electroconvulsive Therapy: A Randomized Controlled Trial Completed NCT03863925 Phase 4
21 Lamictal for Use in Treatment of Bipolar Disorder In Adults. A Practical Clinical Assessment of Tolerability and Clinical Effectiveness. Completed NCT00067938 Phase 4 lamotrigine
22 An Open-Label Extension Study to Assess the Safety of Lamotrigine in Subjects With Bipolar Disorder, Who Are in Remission Following a Manic/Hypomanic Index Episode or a Depressive Index Episode. Completed NCT00360126 Phase 4 lamotrigine
23 Lamictal As Add on Treatment in Mixed States of Bipolar Disorder Completed NCT00223509 Phase 4 Lamotrigine
24 Multi-center, Double-blind, Randomized, Comparative Phase 4 Clinical Trial to Evaluate the Efficacy and Safety of Co-administration of Abilify and Depakote in 24-week Treatment of Mania in Patients With Bipolar Disorder Remitted After 6-week Treatment With Abilify and Depakote Completed NCT00545675 Phase 4 Abilify(aripiprazole);Depakote (divalproate)
25 Multi-center, Single Arm, Open Phase IV Clinical Trial to Evaluate the Efficacy and Safety of Co-administration of Abilify With Depakote in the 6-week Treatment of Acute Mania in Patients With Bipolar Disorder Completed NCT00545142 Phase 4 Abilify(Aripiprazole);Depakote(Divalproate)
26 Olanzapine Versus Placebo in the Treatment of Mania in Adolescents With Bipolar I Disorder Completed NCT00050206 Phase 4 Olanzapine;Placebo
27 A 52-week, Open-label Extension Study to Evaluate the Safety and Tolerability of Licarbazepine in the Treatment of Manic Episodes of Bipolar I Disorder Completed NCT00139594 Phase 4 licarbazepine
28 Adjunctive Ziprasidone in Overweight and Obese Patients With Bipolar Disorder Completed NCT00472641 Phase 4 Ziprasidone/Geodon
29 Quetiapine for Bipolar Disorder and Alcohol Dependence Completed NCT00457197 Phase 4 Placebo;Quetiapine
30 A Randomized, Double-Blind, Placebo Controlled Study Of Quetiapine SR (QTP) As Adjunctive Treatment In Mixed States (MS) Of Bipolar Disorder Completed NCT01195363 Phase 4 quetiapine SR;quetiapine sr placebo
31 Aripiprazole in Late Life Bipolar Disorder Completed NCT00194038 Phase 4 Aripiprazole
32 A Randomized, Double-blind, Placebo-controlled Study of the Efficacy of Ropinirole in the Treatment of Depression in Bipolar Disorder Completed NCT00314821 Phase 4 ropinirole
33 Cognitive Enhancement in Bipolar Disorder Completed NCT00597896 Phase 4 pramipexole
34 Memantine and Cognitive Dysfunction in Bipolar Disorder Completed NCT00586066 Phase 4 Memantine;Placebo
35 Olanzapine/Fluoxetine Combination Versus Lamotrigine in the Treatment of Bipolar I Depression Completed NCT00485771 Phase 4 Olanzapine;Fluoxetine;Lamotrigine
36 Gulf Evaluation of VAlproate (Depakine Chrono) in maNia Study Completed NCT00477373 Phase 4 depakine chrono
37 Olanzapine Plus Carbamazepine Versus Carbamazepine Alone in the Treatment of Manic or Mixed Episodes Associated With Bipolar I Disorder Completed NCT00190892 Phase 4 olanzapine;carbamazepine
38 Olanzapine Versus Active Comparator in the Treatment of Bipolar I Disorder, Manic or Mixed Completed NCT00034580 Phase 4 olanzapine;risperidone
39 Adjunctive Topiramate for Treatment of Alcohol Dependence in Patients With Bipolar Disorder Completed NCT00572117 Phase 4 Topiramate
40 Tranylcypromine Treatment of Bipolar Depression Completed NCT01430455 Phase 4 Tranylcypromine
41 Depakote ER Therapy for Mania Comorbid With Substance Abuse Completed NCT00208195 Phase 4 Divalproex ER
42 A Phase IV STudy of the Effectiveness of Quetiapine Extended Release 600mg Once a Day to Control the Symptoms of Manic Phase of Bipolar Disorder. Completed NCT00521365 Phase 4 Quetiapine 600mg
43 A Double-Blind, Randomized, Placebo-Controlled Trial of Ramelteon for the Treatment of Insomnia and Mood Stability in Patients With Euthymic Bipolar Disorder. Completed NCT00552760 Phase 4 Ramelteon;Placebo
44 A Double Blind, Randomized, Placebo Controlled Trial of Aripiprazole Plus Valproate in the Short-Term and Long-Term Treatment of Bipolar Disorder Completed NCT00484471 Phase 4 aripiprazole;valproate;placebo
45 A Phase 4 Double-Blind, Placebo-Controlled Study of Galantamine to Improve Cognitive Dysfunction in Bipolar Disorder Completed NCT00195845 Phase 4 Galantamine;Placebos
46 Olanzapine Versus Divalproex and Placebo in the Treatment of Mild to Moderate Mania Associated With Bipolar I Disorder Completed NCT00094549 Phase 4 olanzapine;divalproex sodium;placebo
47 A Double-Blind, Placebo-Controlled Trial of Lamotrigine In Individuals With Bipolar Disorder and Comorbid Alcohol Dependence Completed NCT01015586 Phase 4 Lamotrigine;Placebo
48 Comparative Effectiveness of a Second Generation Antipsychotic Mood Stabilizer And a Classic Mood Stabilizer for Bipolar Disorder Completed NCT01331304 Phase 4 Lithium;Quetiapine
49 Phase 4 Study: Double-blind Placebo-controlled Trial of Depakote-ER for Depressive and Anxiety Symptoms in Non-refractory Bipolar Depression Completed NCT00226343 Phase 4 Depakote-ER
50 Bipolar Depression Assessment Study on Tx Response Completed NCT00191399 Phase 4 Olanzapine;Fluoxetine

Search NIH Clinical Center for Major Affective Disorder 1

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Carbamazepine
Clonazepam
Clozapine
CLOZAPINE (CARACO)
CLOZAPINE (CLOZARIL)
CLOZAPINE (IVAX)
CLOZAPINE (TEVA)
CLOZAPINE (VERSACLOZ)
Divalproex Sodium
Doxepin
Fazaclo
gabapentin
gabapentin enacarbil
lamotrigine
Lithium
Lithium Aspartate
Lithium Carbonate
lithium citrate
Methotrimeprazine
Mylan brand of clozapine
olanzapine
quetiapine
Quetiapine fumarate
Risperidone
Sodium Valproate
tiagabine
Tiagabine hydrochloride
topiramate
UDL brand of clozapine
Valproic Acid

Genetic Tests for Major Affective Disorder 1

Genetic tests related to Major Affective Disorder 1:

# Genetic test Affiliating Genes
1 Major Affective Disorder 1 29
2 Bipolar Affective Disorder 29

Anatomical Context for Major Affective Disorder 1

MalaCards organs/tissues related to Major Affective Disorder 1:

41
Brain, Testes, Cortex, Eye, Thyroid, Heart, Prefrontal Cortex

Publications for Major Affective Disorder 1

Articles related to Major Affective Disorder 1:

(show top 50) (show all 2095)
# Title Authors PMID Year
1
Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder. 38 8 71
17905754 2008
2
The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6q. 38 8
17924339 2007
3
Genome-wide scan for genes involved in bipolar affective disorder in 70 European families ascertained through a bipolar type I early-onset proband: supportive evidence for linkage at 3p14. 38 8
16534504 2006
4
The dopamine D4 receptor gene 48-base-pair-repeat polymorphism and mood disorders: a meta-analysis. 38 8
15860340 2005
5
Linkage disequilibrium mapping of bipolar affective disorder at 12q23-q24 provides evidence for association at CUX2 and FLJ32356. 38 8
15389760 2005
6
Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees. 38 8
15219468 2004
7
Novel CAG/CTG repeat expansion mutations do not contribute to the genetic risk for most cases of bipolar disorder or schizophrenia. 38 8
14681907 2004
8
A common mechanism of action for three mood-stabilizing drugs. 38 8
12015604 2002
9
A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q. 38 8
11741836 2001
10
Linkage of bipolar disorder to chromosome 18q and the validity of bipolar II disorder. 38 8
11695948 2001
11
Further evidence for a bipolar risk gene on chromosome 12q24 suggested by investigation of haplotype sharing and allelic association in patients from the Faroe Islands. 38 8
11443532 2001
12
An apparently dominant bipolar affective disorder (BPAD) locus on chromosome 20p11.2-q11.2 in a large Turkish pedigree. 38 8
11175298 2001
13
Genome-wide search for linkage of bipolar affective disorders in a very large pedigree derived from a homogeneous population in quebec points to a locus of major effect on chromosome 12q23-q24. 38 8
10490718 1999
14
Mitochondrial genetic analyses suggest selection against maternal lineages in bipolar affective disorder. 38 8
10417293 1999
15
A comprehensive linkage analysis of chromosome 21q22 supports prior evidence for a putative bipolar affective disorder locus. 38 8
9915960 1999
16
A genome-wide search for chromosomal loci linked to mental health wellness in relatives at high risk for bipolar affective disorder among the Old Order Amish. 38 8
9861003 1998
17
No evidence for significant linkage between bipolar affective disorder and chromosome 18 pericentromeric markers in a large series of multiplex extended pedigrees. 38 8
9529343 1998
18
Significant linkage between bipolar affective disorder and chromosome 12q24. 38 8
9800214 1998
19
Lack of linkage between the corticotropin-releasing hormone (CRH) gene and bipolar affective disorder. 38 8
9399692 1997
20
Two-locus admixture linkage analysis of bipolar and unipolar affective disorder supports the presence of susceptibility loci on chromosomes 11p15 and 21q22. 38 8
9119364 1997
21
A locus for bipolar affective disorder on chromosome 4p. 38 8
8630499 1996
22
A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish. 38 8
8630500 1996
23
Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. 38 8
8533768 1995
24
Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the Old Order Amish. 38 8
7668292 1995
25
Genetics of bipolar affective disorder: time for another reinvention? 38 8
7762549 1995
26
Patterns of maternal transmission in bipolar affective disorder. 38 8
7762550 1995
27
Exclusion of close linkage of bipolar disorder to the Gs-alpha subunit gene in nine Australian pedigrees. 38 8
7531727 1994
28
A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3. 38 8
7874172 1994
29
Anticipation in bipolar affective disorder. 38 8
8328456 1993
30
A genome-wide search for genes predisposing to manic-depression, assuming autosomal dominant inheritance. 38 8
8503452 1993
31
Genetic linkage analysis of bipolar affective disorder in an Old Order Amish pedigree. 38 8
1551659 1992
32
Bipolar affective disorder and thalassemia minor. 38 8
3717440 1986
33
Variant GADL1 and response to lithium in bipolar I disorder. 8
24806176 2014
34
Variant GADL1 and response to lithium in bipolar I disorder. 8
24806172 2014
35
Variant GADL1 and response to lithium in bipolar I disorder. 8
24806173 2014
36
Variant GADL1 and response to lithium in bipolar I disorder. 8
24806174 2014
37
Variant GADL1 and response to lithium in bipolar I disorder. 8
24806175 2014
38
Variant GADL1 and response to lithium in bipolar I disorder. 8
24806177 2014
39
Variant GADL1 and response to lithium therapy in bipolar I disorder. 8
24369049 2014
40
Genetics of bipolar disorder. 8
23663951 2013
41
A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression. 8
19944402 2009
42
Functional properties of missense variants of human tryptophan hydroxylase 2. 71
19319927 2009
43
Genetics of bipolar disorder: successful start to a long journey. 8
19144440 2009
44
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. 8
18711365 2008
45
BAG1 plays a critical role in regulating recovery from both manic-like and depression-like behavioral impairments. 8
18562287 2008
46
Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. 8
18319075 2008
47
Molecular genetics of bipolar disorder and depression. 8
17239033 2007
48
Familial pathways to suicidal behavior--understanding and preventing suicide among adolescents. 8
17192535 2006
49
Genome-wide linkage scan in a large bipolar disorder sample from the National Institute of Mental Health genetics initiative suggests putative loci for bipolar disorder, psychosis, suicide, and panic disorder. 8
16402137 2006
50
Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3. 8
16205735 2006

Variations for Major Affective Disorder 1

ClinVar genetic disease variations for Major Affective Disorder 1:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 TPH2 NM_173353.4(TPH2): c.616C> T (p.Pro206Ser) single nucleotide variant risk factor rs17110563 12:72366306-72366306 12:71972526-71972526
2 46;X;inv(X)(q27q28) inversion Uncertain significance
3 CLCN2 NM_004366.6(CLCN2): c.740G> T (p.Gly247Val) single nucleotide variant Uncertain significance rs1553856477 3:184075440-184075440 3:184357652-184357652

Expression for Major Affective Disorder 1

Search GEO for disease gene expression data for Major Affective Disorder 1.

Pathways for Major Affective Disorder 1

GO Terms for Major Affective Disorder 1

Sources for Major Affective Disorder 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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