MAFD1
MCID: MJR007
MIFTS: 44

Major Affective Disorder 1 (MAFD1)

Categories: Genetic diseases, Mental diseases

Aliases & Classifications for Major Affective Disorder 1

MalaCards integrated aliases for Major Affective Disorder 1:

Name: Major Affective Disorder 1 56 12 29 13 71
Bipolar Affective Disorder 56 29 6 32
Bipolar Affective Disorder, Susceptibility to 6
Manic-Depressive Psychosis, Autosomal 56
Bipolar Affective Disorder; Bpad 56
Manic-Depressive Psychosis; Md1 56
Manic-Depressive Psychosis 56
Bipolar Disorder 71
Mafd1 56
Bpad 56
Md1 56

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant


HPO:

31
major affective disorder 1:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:0080220
OMIM 56 125480
ICD10 32 F31 F31.9
MedGen 41 C1852197
UMLS 71 C0005586 C1852197

Summaries for Major Affective Disorder 1

MalaCards based summary : Major Affective Disorder 1, also known as bipolar affective disorder, is related to bipolar disorder and major affective disorder 2. An important gene associated with Major Affective Disorder 1 is MAFD1 (Major Affective Disorder 1). The drugs Eleuthero and Reboxetine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related phenotypes are depressivity and mania

More information from OMIM: 125480

Related Diseases for Major Affective Disorder 1

Diseases in the Major Affective Disorder 1 family:

Major Affective Disorder 2 Major Affective Disorder 3
Major Affective Disorder 4 Major Affective Disorder 5
Major Affective Disorder 6 Major Affective Disorder 8
Major Affective Disorder 7 Major Affective Disorder 9

Diseases related to Major Affective Disorder 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 206, show less)
# Related Disease Score Top Affiliating Genes
1 bipolar disorder 31.1 TPH2 MAFD1
2 major affective disorder 2 12.2
3 major affective disorder 5 12.1
4 major affective disorder 6 12.1
5 myotonic dystrophy 1 12.1
6 major affective disorder 4 11.8
7 mental retardation, x-linked, syndromic 13 11.7
8 major affective disorder 3 11.6
9 major affective disorder 7 11.5
10 schizophrenia 10.6
11 depression 10.6
12 bipolar i disorder 10.4
13 major affective disorder 8 10.4
14 major affective disorder 9 10.4
15 mental depression 10.4
16 major depressive disorder 10.4
17 neurotic disorder 10.4
18 myopathy 10.3
19 myotonic dystrophy 10.3
20 dysphagia 10.3
21 personality disorder 10.3
22 schizoaffective disorder 10.3
23 alcohol dependence 10.3
24 tardive dyskinesia 10.3
25 obsessive-compulsive disorder 10.3
26 yemenite deaf-blind hypopigmentation syndrome 10.3
27 depersonalization disorder 10.3
28 psychotic disorder 10.3
29 melancholia 10.3
30 mood disorder 10.3
31 hypothyroidism 10.2
32 substance abuse 10.2
33 glucose intolerance 10.2
34 ischemia 10.2
35 cyclothymic disorder 10.2
36 huntington disease 10.1
37 attention deficit-hyperactivity disorder 10.1
38 mental health wellness 1 10.1
39 mental health wellness 2 10.1
40 severe combined immunodeficiency 10.1
41 pfeiffer syndrome 10.1
42 multiple sclerosis 10.1
43 hand skill, relative 10.1
44 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
45 anxiety 10.1
46 aphasia 10.1
47 hypogonadotropic hypogonadism 10.1
48 sexual sadism 10.1
49 dysthymic disorder 10.1
50 obstructive jaundice 10.1
51 methylmalonic acidemia 10.1
52 endogenous depression 10.1
53 factitious disorder 10.1
54 epilepsy 10.1
55 arthropathy 10.1
56 syphilis 10.1
57 kidney disease 10.1
58 hyperthyroidism 10.1
59 tertiary syphilis 10.1
60 appendicitis 10.1
61 thrombasthenia 10.1
62 head injury 10.1
63 tremor 10.1
64 autism 10.1
65 thalassemia 10.1
66 hydrocephalus 10.1
67 borderline personality disorder 10.1
68 avoidant personality disorder 10.1
69 adenoma 10.1
70 schizophrenia 1 10.0
71 frontotemporal dementia 10.0
72 alacrima, achalasia, and mental retardation syndrome 10.0
73 exanthem 10.0
74 physical disorder 10.0
75 dementia 10.0
76 alcohol use disorder 10.0
77 movement disease 10.0
78 panic disorder 10.0
79 learning disability 10.0
80 substance dependence 10.0
81 darier-white disease 9.9
82 lithium transport 9.9
83 wolfram syndrome 1 9.9
84 orthostatic intolerance 9.9
85 alveolar soft part sarcoma 9.9
86 anorexia nervosa 9.9
87 bulimia nervosa 9.9
88 beta-thalassemia 9.9
89 sexual disorder 9.9
90 wolfram syndrome 9.9
91 pertussis 9.9
92 hyperparathyroidism 9.9
93 keratosis 9.9
94 pituitary adenoma 9.9
95 cerebrovascular disease 9.9
96 thyroiditis 9.9
97 parathyroid adenoma 9.9
98 periodontitis 9.9
99 subacute delirium 9.9
100 47,xyy 9.9
101 48,xyyy 9.9
102 cytokine deficiency 9.9
103 postpartum psychosis 9.9
104 early-onset schizophrenia 9.9
105 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 9.8
106 fibrosis of extraocular muscles, congenital, 1 9.8
107 gilles de la tourette syndrome 9.8
108 holt-oram syndrome 9.8
109 jacobsen syndrome 9.8
110 klippel-trenaunay-weber syndrome 9.8
111 migraine with or without aura 1 9.8
112 hypokalemic periodic paralysis, type 1 9.8
113 mccune-albright syndrome 9.8
114 prader-willi syndrome 9.8
115 pulmonary fibrosis, idiopathic 9.8
116 down syndrome 9.8
117 velocardiofacial syndrome 9.8
118 arachnoid cysts, intracranial 9.8
119 dandy-walker syndrome 9.8
120 ellis-van creveld syndrome 9.8
121 hydrocephalus, normal-pressure 9.8
122 schizencephaly 9.8
123 graves disease 1 9.8
124 spinal and bulbar muscular atrophy, x-linked 1 9.8
125 kearns-sayre syndrome 9.8
126 stroke, ischemic 9.8
127 branchiootic syndrome 1 9.8
128 schizophrenia 2 9.8
129 phobia, specific 9.8
130 severe cutaneous adverse reaction 9.8
131 schizophrenia 14 9.8
132 schizophrenia 13 9.8
133 schizophrenia 15 9.8
134 schizophrenia 18 9.8
135 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.8
136 schizophrenia 19 9.8
137 aspiration pneumonia 9.8
138 erythema multiforme 9.8
139 sleep apnea 9.8
140 autism spectrum disorder 9.8
141 alexithymia 9.8
142 body dysmorphic disorder 9.8
143 crohn's colitis 9.8
144 stuttering 9.8
145 fibrous dysplasia 9.8
146 leukodystrophy 9.8
147 giardiasis 9.8
148 thrombotic thrombocytopenic purpura 9.8
149 obsessive-compulsive personality disorder 9.8
150 antisocial personality disorder 9.8
151 hemiplegia 9.8
152 primary hyperparathyroidism 9.8
153 social phobia 9.8
154 solar retinopathy 9.8
155 polycystic ovary syndrome 9.8
156 goiter 9.8
157 neutropenia 9.8
158 atypical depressive disorder 9.8
159 chronic progressive external ophthalmoplegia 9.8
160 gout 9.8
161 cerebral degeneration 9.8
162 neuroleptic malignant syndrome 9.8
163 status epilepticus 9.8
164 post-traumatic stress disorder 9.8
165 focal epilepsy 9.8
166 acromegaly 9.8
167 hereditary spastic paraplegia 9.8
168 kluver-bucy syndrome 9.8
169 narcissistic personality disorder 9.8
170 idiopathic interstitial pneumonia 9.8
171 purpura 9.8
172 pulmonary fibrosis 9.8
173 mutism 9.8
174 sleep disorder 9.8
175 pneumonia 9.8
176 agoraphobia 9.8
177 paraplegia 9.8
178 acute stress disorder 9.8
179 premenstrual tension 9.8
180 epilepsy with generalized tonic-clonic seizures 9.8
181 delusional disorder 9.8
182 cocaine abuse 9.8
183 eating disorder 9.8
184 crohn's disease 9.8
185 narcolepsy 9.8
186 speech disorder 9.8
187 homocystinuria 9.8
188 priapism 9.8
189 diabetes insipidus 9.8
190 pulmonary embolism 9.8
191 postpartum depression 9.8
192 alopecia 9.8
193 congenital disorders of n-linked glycosylation and multiple pathway 9.8
194 chromosomal triplication 9.8
195 dipsogenic diabetes insipidus 9.8
196 dwarfism 9.8
197 stevens-johnson syndrome/toxic epidermal necrolysis 9.8
198 anoxia 9.8
199 cerebral atrophy 9.8
200 encephalopathy 9.8
201 hypersomnia 9.8
202 seizure disorder 9.8
203 cerebral malformation 9.8
204 periodic paralysis 9.8
205 erythema multiforme major 9.8
206 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 9.8

Graphical network of the top 20 diseases related to Major Affective Disorder 1:



Diseases related to Major Affective Disorder 1

Symptoms & Phenotypes for Major Affective Disorder 1

Human phenotypes related to Major Affective Disorder 1:

31 (showing 2, show less)
# Description HPO Frequency HPO Source Accession
1 depressivity 31 HP:0000716
2 mania 31 HP:0100754

Symptoms via clinical synopsis from OMIM:

56
Neurologic Behavioral Psychiatric Manifestations:
depression with mania (bipolar 1)
depression with hypomania (bipolar 2)

Clinical features from OMIM:

125480

Drugs & Therapeutics for Major Affective Disorder 1

Drugs for Major Affective Disorder 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 442, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Eleuthero Approved, Experimental Phase 4
2
Reboxetine Approved, Experimental Phase 4 98769-81-4, 71620-89-8 123628 65856
3
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
4
Galantamine Approved Phase 4 357-70-0 9651
5
Ropinirole Approved, Investigational Phase 4 91374-20-8, 91374-21-9 497540 5095
6
Memantine Approved, Investigational Phase 4 19982-08-2 4054
7
Topiramate Approved Phase 4 97240-79-4 5284627
8
Tranylcypromine Approved, Investigational Phase 4 155-09-9 441233
9
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
10
Cocaine Approved, Illicit Phase 4 50-36-2 5760 446220
11
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
12
Acamprosate Approved, Investigational Phase 4 77337-76-9 71158
13
Levetiracetam Approved Phase 4 102767-28-2 441341
14
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
15
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
16
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
17
Cycloserine Approved Phase 4 68-41-7 401 6234
18
Norepinephrine Approved Phase 4 51-41-2 439260
19
Sertraline Approved Phase 4 79617-96-2 68617
20
Nortriptyline Approved Phase 4 72-69-5 4543
21
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
22
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
23
Mirtazapine Approved Phase 4 85650-52-8, 61337-67-5 4205
24
Histamine Approved, Investigational Phase 4 51-45-6 774
25
Iloperidone Approved Phase 4 133454-47-4 71360
26
Brexpiprazole Approved, Investigational Phase 4 913611-97-9 11978813
27
Methohexital Approved Phase 4 151-83-7 9034
28
Dipyridamole Approved Phase 4 58-32-2 3108
29
Chlorpromazine Approved, Investigational, Vet_approved Phase 4 50-53-3 2726
30
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
31
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
32
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
33
Varenicline Approved, Investigational Phase 4 249296-44-4 5310966
34
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
35
Loxapine Approved Phase 4 1977-10-2 3964
36
Metformin Approved Phase 4 657-24-9 4091 14219
37
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
38
Racepinephrine Approved Phase 4 329-65-7 838
39
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
40
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 15589840
41
Amphetamine Approved, Illicit, Investigational Phase 4 300-62-9 5826 3007
42
Dextroamphetamine Approved, Illicit Phase 4 51-64-9 5826
43
Acetaminophen Approved Phase 4 103-90-2 1983
44
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
45
Ondansetron Approved Phase 4 99614-02-5 4595
46
Simvastatin Approved Phase 4 79902-63-9 54454
47
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 11128-99-7, 4474-91-3 172198
48
Losartan Approved Phase 4 114798-26-4 3961
49
Oxcarbazepine Approved Phase 4 28721-07-5 34312
50
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
51
Promethazine Approved, Investigational Phase 4 60-87-7 4927
52
Clozapine Approved Phase 4 5786-21-0 2818
53
Suvorexant Approved, Investigational Phase 4 1030377-33-3
54
Lorazepam Approved Phase 4 846-49-1 3958
55
gamma-Aminobutyric acid Approved, Investigational Phase 4 56-12-2 119
56
Succinylcholine Approved Phase 4 306-40-1 5314
57
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
58
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
59
Lamotrigine Approved, Investigational Phase 4 84057-84-1 3878
60
Ziprasidone Approved Phase 4 146939-27-7 60854
61
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
62
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
63
Zonisamide Approved, Investigational Phase 4 68291-97-4 5734
64
Allopurinol Approved Phase 4 315-30-0 2094
65
Haloperidol Approved Phase 4 52-86-8 3559
66
Citalopram Approved Phase 4 59729-33-8 2771
67
Midazolam Approved, Illicit Phase 4 59467-70-8 4192