MAFD1
MCID: MJR007
MIFTS: 43

Major Affective Disorder 1 (MAFD1)

Categories: Genetic diseases, Mental diseases

Aliases & Classifications for Major Affective Disorder 1

MalaCards integrated aliases for Major Affective Disorder 1:

Name: Major Affective Disorder 1 56 12 29 13 71
Bipolar Affective Disorder 56 29 6 32
Bipolar Affective Disorder, Susceptibility to 6
Manic-Depressive Psychosis, Autosomal 56
Bipolar Affective Disorder; Bpad 56
Manic-Depressive Psychosis; Md1 56
Manic-Depressive Psychosis 56
Bipolar Disorder 71
Mafd1 56
Bpad 56
Md1 56

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant


HPO:

31
major affective disorder 1:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:0080220
OMIM 56 125480
ICD10 32 F31 F31.9
MedGen 41 C1852197
UMLS 71 C0005586 C1852197

Summaries for Major Affective Disorder 1

MalaCards based summary : Major Affective Disorder 1, also known as bipolar affective disorder, is related to major affective disorder 2 and major affective disorder 5. An important gene associated with Major Affective Disorder 1 is MAFD1 (Major Affective Disorder 1). The drugs Eleuthero and Reboxetine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related phenotypes are depressivity and mania

More information from OMIM: 125480

Related Diseases for Major Affective Disorder 1

Diseases in the Major Affective Disorder 1 family:

Major Affective Disorder 2 Major Affective Disorder 3
Major Affective Disorder 4 Major Affective Disorder 5
Major Affective Disorder 6 Major Affective Disorder 8
Major Affective Disorder 7 Major Affective Disorder 9

Diseases related to Major Affective Disorder 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 207, show less)
# Related Disease Score Top Affiliating Genes
1 major affective disorder 2 12.2
2 major affective disorder 5 12.2
3 major affective disorder 6 12.2
4 myotonic dystrophy 1 12.1
5 major affective disorder 4 11.8
6 mental retardation, x-linked, syndromic 13 11.7
7 major affective disorder 3 11.7
8 major affective disorder 7 11.5
9 bipolar disorder 11.5
10 schizophrenia 10.6
11 depression 10.5
12 bipolar i disorder 10.4
13 major affective disorder 8 10.4
14 major affective disorder 9 10.4
15 mental depression 10.4
16 major depressive disorder 10.4
17 myopathy 10.4
18 myotonic dystrophy 10.4
19 dysphagia 10.4
20 neurotic disorder 10.3
21 personality disorder 10.3
22 schizoaffective disorder 10.3
23 alcohol dependence 10.3
24 tardive dyskinesia 10.3
25 obsessive-compulsive disorder 10.3
26 yemenite deaf-blind hypopigmentation syndrome 10.3
27 depersonalization disorder 10.3
28 psychotic disorder 10.3
29 melancholia 10.3
30 mood disorder 10.3
31 substance abuse 10.2
32 glucose intolerance 10.2
33 ischemia 10.2
34 hypothyroidism 10.2
35 attention deficit-hyperactivity disorder 10.2
36 cyclothymic disorder 10.2
37 huntington disease 10.1
38 mental health wellness 1 10.1
39 mental health wellness 2 10.1
40 borderline personality disorder 10.1
41 severe combined immunodeficiency 10.1
42 pfeiffer syndrome 10.1
43 multiple sclerosis 10.1
44 hand skill, relative 10.1
45 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
46 asthma 10.1
47 anxiety 10.1
48 aphasia 10.1
49 hypogonadotropic hypogonadism 10.1
50 sexual sadism 10.1
51 dysthymic disorder 10.1
52 obstructive jaundice 10.1
53 methylmalonic acidemia 10.1
54 endogenous depression 10.1
55 factitious disorder 10.1
56 epilepsy 10.1
57 arthropathy 10.1
58 syphilis 10.1
59 kidney disease 10.1
60 hyperthyroidism 10.1
61 tertiary syphilis 10.1
62 appendicitis 10.1
63 thrombasthenia 10.1
64 head injury 10.1
65 tremor 10.1
66 thalassemia 10.1
67 hydrocephalus 10.1
68 avoidant personality disorder 10.1
69 adenoma 10.1
70 schizophrenia 1 10.0
71 frontotemporal dementia 10.0
72 alacrima, achalasia, and mental retardation syndrome 10.0
73 exanthem 10.0
74 physical disorder 10.0
75 dementia 10.0
76 alcohol use disorder 10.0
77 movement disease 10.0
78 panic disorder 10.0
79 learning disability 10.0
80 substance dependence 10.0
81 darier-white disease 9.9
82 lithium transport 9.9
83 autism 9.9
84 wolfram syndrome 1 9.9
85 orthostatic intolerance 9.9
86 alveolar soft part sarcoma 9.9
87 anorexia nervosa 9.9
88 bulimia nervosa 9.9
89 beta-thalassemia 9.9
90 sexual disorder 9.9
91 wolfram syndrome 9.9
92 pertussis 9.9
93 hyperparathyroidism 9.9
94 keratosis 9.9
95 pituitary adenoma 9.9
96 thyroiditis 9.9
97 parathyroid adenoma 9.9
98 periodontitis 9.9
99 subacute delirium 9.9
100 47,xyy 9.9
101 48,xyyy 9.9
102 cytokine deficiency 9.9
103 postpartum psychosis 9.9
104 early-onset schizophrenia 9.9
105 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 9.8
106 fibrosis of extraocular muscles, congenital, 1 9.8
107 gilles de la tourette syndrome 9.8
108 holt-oram syndrome 9.8
109 jacobsen syndrome 9.8
110 klippel-trenaunay-weber syndrome 9.8
111 migraine with or without aura 1 9.8
112 hypokalemic periodic paralysis, type 1 9.8
113 mccune-albright syndrome 9.8
114 prader-willi syndrome 9.8
115 pulmonary fibrosis, idiopathic 9.8
116 down syndrome 9.8
117 velocardiofacial syndrome 9.8
118 arachnoid cysts, intracranial 9.8
119 dandy-walker syndrome 9.8
120 ellis-van creveld syndrome 9.8
121 schizencephaly 9.8
122 graves disease 1 9.8
123 spinal and bulbar muscular atrophy, x-linked 1 9.8
124 kearns-sayre syndrome 9.8
125 stroke, ischemic 9.8
126 branchiootic syndrome 1 9.8
127 schizophrenia 2 9.8
128 phobia, specific 9.8
129 severe cutaneous adverse reaction 9.8
130 schizophrenia 14 9.8
131 schizophrenia 13 9.8
132 schizophrenia 15 9.8
133 schizophrenia 18 9.8
134 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.8
135 schizophrenia 19 9.8
136 aspiration pneumonia 9.8
137 erythema multiforme 9.8
138 sleep apnea 9.8
139 autism spectrum disorder 9.8
140 alexithymia 9.8
141 body dysmorphic disorder 9.8
142 crohn's colitis 9.8
143 stuttering 9.8
144 fibrous dysplasia 9.8
145 leukodystrophy 9.8
146 giardiasis 9.8
147 thrombotic thrombocytopenic purpura 9.8
148 obsessive-compulsive personality disorder 9.8
149 antisocial personality disorder 9.8
150 hemiplegia 9.8
151 primary hyperparathyroidism 9.8
152 social phobia 9.8
153 solar retinopathy 9.8
154 polycystic ovary syndrome 9.8
155 goiter 9.8
156 neutropenia 9.8
157 atypical depressive disorder 9.8
158 chronic progressive external ophthalmoplegia 9.8
159 gout 9.8
160 cerebral degeneration 9.8
161 neuroleptic malignant syndrome 9.8
162 normal pressure hydrocephalus 9.8
163 status epilepticus 9.8
164 post-traumatic stress disorder 9.8
165 focal epilepsy 9.8
166 acromegaly 9.8
167 hereditary spastic paraplegia 9.8
168 kluver-bucy syndrome 9.8
169 narcissistic personality disorder 9.8
170 purpura 9.8
171 pulmonary fibrosis 9.8
172 mutism 9.8
173 sleep disorder 9.8
174 pneumonia 9.8
175 agoraphobia 9.8
176 paraplegia 9.8
177 acute stress disorder 9.8
178 cerebrovascular disease 9.8
179 mitochondrial metabolism disease 9.8
180 premenstrual tension 9.8
181 epilepsy with generalized tonic-clonic seizures 9.8
182 delusional disorder 9.8
183 cocaine abuse 9.8
184 eating disorder 9.8
185 crohn's disease 9.8
186 narcolepsy 9.8
187 speech disorder 9.8
188 homocystinuria 9.8
189 priapism 9.8
190 diabetes insipidus 9.8
191 pulmonary embolism 9.8
192 postpartum depression 9.8
193 alopecia 9.8
194 congenital disorders of n-linked glycosylation and multiple pathway 9.8
195 mitochondrial disorders 9.8
196 chromosomal triplication 9.8
197 dipsogenic diabetes insipidus 9.8
198 dwarfism 9.8
199 stevens-johnson syndrome/toxic epidermal necrolysis 9.8
200 anoxia 9.8
201 cerebral atrophy 9.8
202 encephalopathy 9.8
203 hypersomnia 9.8
204 seizure disorder 9.8
205 periodic paralysis 9.8
206 erythema multiforme major 9.8
207 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 9.8

Graphical network of the top 20 diseases related to Major Affective Disorder 1:



Diseases related to Major Affective Disorder 1

Symptoms & Phenotypes for Major Affective Disorder 1

Human phenotypes related to Major Affective Disorder 1:

31 (showing 2, show less)
# Description HPO Frequency HPO Source Accession
1 depressivity 31 HP:0000716
2 mania 31 HP:0100754

Symptoms via clinical synopsis from OMIM:

56
Neurologic Behavioral Psychiatric Manifestations:
depression with mania (bipolar 1)
depression with hypomania (bipolar 2)

Clinical features from OMIM:

125480

Drugs & Therapeutics for Major Affective Disorder 1

Drugs for Major Affective Disorder 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 425, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Eleuthero Approved, Experimental Phase 4
2
Reboxetine Approved, Experimental Phase 4 98769-81-4, 71620-89-8 123628 65856
3
Oxcarbazepine Approved Phase 4 28721-07-5 34312
4
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
5
Galantamine Approved Phase 4 357-70-0 9651
6
Ropinirole Approved, Investigational Phase 4 91374-20-8, 91374-21-9 497540 5095
7
Memantine Approved, Investigational Phase 4 19982-08-2 4054
8
Topiramate Approved Phase 4 97240-79-4 5284627
9
Tranylcypromine Approved, Investigational Phase 4 155-09-9 441233
10
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
11
Cocaine Approved, Illicit Phase 4 50-36-2 446220 5760
12
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
13
Acamprosate Approved, Investigational Phase 4 77337-76-9 71158
14
Levetiracetam Approved Phase 4 102767-28-2 441341
15
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
16
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
17
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
18
Cycloserine Approved Phase 4 68-41-7 401 6234
19
Norepinephrine Approved Phase 4 51-41-2 439260
20
Sertraline Approved Phase 4 79617-96-2 68617
21
Nortriptyline Approved Phase 4 72-69-5 4543
22
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
23
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
24
Histamine Approved, Investigational Phase 4 51-45-6 774
25
Mirtazapine Approved Phase 4 85650-52-8, 61337-67-5 4205
26
Iloperidone Approved Phase 4 133454-47-4 71360
27
Brexpiprazole Approved, Investigational Phase 4 913611-97-9 11978813
28
Methohexital Approved Phase 4 151-83-7 9034
29
Dipyridamole Approved Phase 4 58-32-2 3108
30
Chlorpromazine Approved, Investigational, Vet_approved Phase 4 50-53-3 2726
31
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
32
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
33
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
34
Lorazepam Approved Phase 4 846-49-1 3958
35
Varenicline Approved, Investigational Phase 4 249296-44-4 5310966
36
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
37
Loxapine Approved Phase 4 1977-10-2 3964
38
Metformin Approved Phase 4 657-24-9 14219 4091
39
Dextroamphetamine Approved, Illicit Phase 4 51-64-9 5826
40
Amphetamine Approved, Illicit, Investigational Phase 4 300-62-9 5826 3007
41
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
42
Hydroxocobalamin Approved Phase 4 13422-51-0 15589840 11953898
43
Acetaminophen Approved Phase 4 103-90-2 1983
44
gamma-Aminobutyric acid Approved, Investigational Phase 4 56-12-2 119
45
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
46
Angiotensin II Approved, Investigational Phase 4 4474-91-3, 11128-99-7, 68521-88-0 172198
47
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
48
Racepinephrine Approved Phase 4 329-65-7 838
49
Ondansetron Approved Phase 4 99614-02-5 4595
50
Simvastatin Approved Phase 4 79902-63-9 54454
51
Losartan Approved Phase 4 114798-26-4 3961
52
Promethazine Approved, Investigational Phase 4 60-87-7 4927
53
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
54
Clozapine Approved Phase 4 5786-21-0 2818
55
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
56
Suvorexant Approved, Investigational Phase 4 1030377-33-3
57
Succinylcholine Approved Phase 4 306-40-1 5314
58
Bupropion Approved Phase 4 34911-55-2, 34841-39-9 444
59
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
60
Lamotrigine Approved, Investigational Phase 4 84057-84-1 3878
61
Ziprasidone Approved Phase 4 146939-27-7 60854
62
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
63
Zonisamide Approved, Investigational Phase 4 68291-97-4 5734
64
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
65
Haloperidol Approved Phase 4 52-86-8 3559
66
Allopurinol Approved Phase 4 315-30-0 2094
67