MAFD2
MCID: MJR008
MIFTS: 32

Major Affective Disorder 2 (MAFD2)

Categories: Genetic diseases, Mental diseases

Aliases & Classifications for Major Affective Disorder 2

MalaCards integrated aliases for Major Affective Disorder 2:

Name: Major Affective Disorder 2 58 12 13 74
Manic-Depressive Psychosis, X-Linked; Mdx 58
Manic-Depressive Psychosis, X-Linked 58
Bipolar Affective Disorder; Bpad 58
Manic-Depressive Illness; Mdi 58
Bipolar Affective Disorder 58
Manic-Depressive Illness 58
Bipolar Disorder 74
Mafd2 58
Bpad 58
Mdi 58
Mdx 58

Characteristics:

OMIM:

58
Inheritance:
? x-linked dominant vs. multifactorial


HPO:

33
major affective disorder 2:
Onset and clinical course infantile onset
Inheritance x-linked dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:0080221
OMIM 58 309200
MedGen 43 C1839839
SNOMED-CT via HPO 70 13746004

Summaries for Major Affective Disorder 2

MalaCards based summary : Major Affective Disorder 2, also known as manic-depressive psychosis, x-linked; mdx, is related to major affective disorder 1 and major affective disorder 4. An important gene associated with Major Affective Disorder 2 is MAFD2 (Major Affective Disorder 2). The drugs Lithium carbonate and Valproic Acid have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and ovary, and related phenotype is bipolar affective disorder.

Description from OMIM: 309200

Related Diseases for Major Affective Disorder 2

Diseases in the Major Affective Disorder 1 family:

Major Affective Disorder 2 Major Affective Disorder 3
Major Affective Disorder 4 Major Affective Disorder 5
Major Affective Disorder 6 Major Affective Disorder 8
Major Affective Disorder 7 Major Affective Disorder 9

Diseases related to Major Affective Disorder 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 major affective disorder 1 12.0
2 major affective disorder 4 12.0
3 major affective disorder 5 12.0
4 major affective disorder 6 12.0
5 major affective disorder 3 11.5
6 major affective disorder 7 11.4
7 bipolar disorder 11.4
8 diabetes mellitus, permanent neonatal 11.2
9 diphenylmethane-4,4'-diisocyanate allergic asthma 11.1
10 diphenylmethane-4,4'-diisocyanate allergic contact dermatitis 11.1
11 cone-rod dystrophy and hearing loss 2 11.1
12 muscular dystrophy 11.0
13 muscular dystrophy, duchenne type 10.9
14 schizophrenia 10.7
15 depression 10.4
16 major affective disorder 8 10.4
17 major affective disorder 9 10.4
18 dystrophinopathies 10.3
19 asthma 10.3
20 color blindness 10.3
21 color vision deficiency 10.3
22 gas gangrene 10.3
23 insulin-like growth factor i 10.2
24 tardive dyskinesia 10.2
25 personality disorder 10.2
26 paranoid schizophrenia 10.2
27 muscle hypertrophy 10.2
28 multiple sclerosis 10.2
29 obsessive-compulsive disorder 10.2
30 major depressive disorder 10.2
31 disease of mental health 10.1
32 endogenous depression 10.1
33 hypoxia 10.1
34 extrinsic allergic alveolitis 10.1
35 influenza 10.1
36 thalassemia 10.1
37 dementia 10.1
38 substance abuse 10.1
39 prader-willi syndrome 10.0
40 fragile x syndrome 10.0
41 colorblindness, partial, deutan series 10.0
42 aceruloplasminemia 10.0
43 antisocial personality disorder 10.0
44 aseptic meningitis 10.0
45 diabetes insipidus 10.0
46 meningitis 10.0
47 tremor 10.0
48 hypersomnia 10.0
49 rheumatoid arthritis 10.0
50 polyglucosan body myopathy 1 with or without immunodeficiency 10.0

Graphical network of the top 20 diseases related to Major Affective Disorder 2:



Diseases related to Major Affective Disorder 2

Symptoms & Phenotypes for Major Affective Disorder 2

Human phenotypes related to Major Affective Disorder 2:

33
# Description HPO Frequency HPO Source Accession
1 bipolar affective disorder 33 HP:0007302

Symptoms via clinical synopsis from OMIM:

58
Neuro:
bipolar affective disorder

Misc:
early onset (before 30 years of age)

Clinical features from OMIM:

309200

Drugs & Therapeutics for Major Affective Disorder 2

Drugs for Major Affective Disorder 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 94)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lithium carbonate Approved Phase 4,Phase 3,Not Applicable 554-13-2
2
Valproic Acid Approved, Investigational Phase 4,Not Applicable 99-66-1 3121
3
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
4
Dopamine Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 62-31-7, 51-61-6 681
5
Succinylcholine Approved Phase 4 306-40-1 5314
6
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
7
Paroxetine Approved, Investigational Phase 4,Phase 3,Not Applicable 61869-08-7 43815
8
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
9
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
10 Tranquilizing Agents Phase 4,Phase 3,Phase 2,Not Applicable
11 Psychotropic Drugs Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
12 Antidepressive Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
13 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
14 Quetiapine Fumarate Phase 4 111974-72-2
15 Antipsychotic Agents Phase 4,Phase 3,Phase 2,Not Applicable
16 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
17 Antimanic Agents Phase 4,Phase 3,Not Applicable
18 GABA Agents Phase 4,Not Applicable
19 Anticonvulsants Phase 4,Phase 3,Phase 2,Not Applicable
20 Dopamine Antagonists Phase 4,Phase 2,Not Applicable
21 Dopamine Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
22 Serotonin Antagonists Phase 4,Phase 2,Not Applicable
23 Dopamine D2 Receptor Antagonists Phase 4
24 Serotonin 5-HT1 Receptor Agonists Phase 4
25 Serotonin Agents Phase 4,Phase 3,Phase 2,Not Applicable
26 Serotonin 5-HT2 Receptor Antagonists Phase 4
27 Serotonin Receptor Agonists Phase 4
28 Dopamine agonists Phase 4
29 Antioxidants Phase 4
30 Protective Agents Phase 4,Phase 2
31 Anesthetics, Intravenous Phase 4
32 Hypnotics and Sedatives Phase 4
33 Anesthetics, General Phase 4
34 Anesthetics Phase 4
35 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
36 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
37 Antidepressive Agents, Second-Generation Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
38 Cytochrome P-450 CYP2D6 Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
39 Serotonin Uptake Inhibitors Phase 4,Phase 3,Not Applicable
40 Excitatory Amino Acid Antagonists Phase 4,Phase 2
41 Peripheral Nervous System Agents Phase 4
42 Anesthetics, Dissociative Phase 4
43 Analgesics Phase 4
44 Excitatory Amino Acids Phase 4,Phase 2
45
Serotonin Investigational, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 50-67-9 5202
46
Lamotrigine Approved, Investigational Phase 3,Not Applicable 84057-84-1 3878
47
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
48
Calcium Approved, Nutraceutical Phase 3,Not Applicable 7440-70-2 271
49 calcium channel blockers Phase 3,Not Applicable
50 Diuretics, Potassium Sparing Phase 3,Not Applicable

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Efficacy and Safety of Flexible Dose of Quetiapine Fumarate (Seroquel) Switching From Other Drugs in the Treatment of Acute Manic Patients With Bipolar Disorder Unknown status NCT00837343 Phase 4 quetiapine fumarate tablet (Seroquel)
2 Transcranial Magnetic Stimulation in Bipolar Depression Completed NCT00186758 Phase 4
3 Aripiprazole in Late Life Bipolar Disorder Completed NCT00194038 Phase 4 Aripiprazole
4 Melatonin Versus Placebo for Benzodiazepine Discontinuation in Patients With Schizophrenia Completed NCT01431092 Phase 4 Placebo;Melatonin
5 Comparison of Propofol Target-Controlled Infusion Anesthesia and Bolus Injection in Electroconvulsive Therapy Completed NCT03863925 Phase 4
6 Lithium Versus Paroxetine in Major Depression Completed NCT01416220 Phase 4 Lithium;Paroxetine
7 Clinical Utility of Pharmacogenomics of Psychotropic Medications Not yet recruiting NCT03907124 Phase 4 Genetically-guided treatment with FDA-approved psychotropic drugs;Treatment as usual (TAU)
8 Comparison of Ketamine Combine Propofol vs Propofol Anesthesia in Schizophrenia Electroconvulsive Therapy Not yet recruiting NCT03829124 Phase 4 Propofol;Ketamine
9 Safety Study of Depakote Versus Lithium in African Americans With Bipolar Disorder Withdrawn NCT01075126 Phase 4 Depakote;Lithium
10 Prophylactic Effect of Lamotrigine Compared With Lithium in Bipolar Disorder Completed NCT00226135 Phase 3 lithium or lamotrigine
11 Methylphenidate for the Treatment of Acute Mania Completed NCT01541605 Phase 3 methylphenidate;Placebo
12 Cannabidiol as an Adjunctive Treatment for Bipolar Depression Recruiting NCT03310593 Phase 2, Phase 3 Cannabidiol;Placebo
13 Lithium Versus Paroxetine in Patients With Major Depression Who Have a Family History of Bipolar Disorder or Suicide Terminated NCT00400088 Phase 3 paroxetine;lithium
14 rTMS in the Treatment of Bipolar Depression Unknown status NCT00436020 Phase 2
15 Anti-Estrogens - A Potential Treatment for Bipolar Affective Disorder in Women? Completed NCT00206544 Phase 2 Tamoxifen;Progesterone
16 A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Affective Disorder Completed NCT00593099 Phase 1, Phase 2 Bupropion;Placebo
17 Safety Study of Ziprasidone (Geodon) for the Depressive Mixed State Completed NCT00490542 Phase 2 ziprasidone (Geodon);placebo
18 Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar Disorder Terminated NCT00805493 Phase 2 Riluzole
19 Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder Withdrawn NCT00327756 Phase 2 Coenzyme Q10
20 Myths About Bipolar Affective Disorder: The Role of Structured Group Psychoeducation Therapy Unknown status NCT00474357 Not Applicable
21 Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder (PGBD) Unknown status NCT01272531 Mood stabilizer treatment
22 Psychiatric Disorders and Electrophysiological Markers Unknown status NCT02329119 Not Applicable
23 A Study of the Association Between Tobacco Smoking and Bipolar Affective Disorder Completed NCT00741299
24 Exercise for Depression Completed NCT02874833 Not Applicable
25 Bipolar Research Study Using MR Imaging Completed NCT02083978
26 Specialized Clozapine Clinic for Bipolar and Schizoaffective Disorder Completed NCT00683709
27 Bipolar Intervention Study: Cognitive Interpersonal Therapy Completed NCT01315028 Not Applicable
28 Genetic Aspects of Neurologic and Psychiatric Disorders Completed NCT00001544
29 Early Integrated Intervention in Severe Affective Disorders Completed NCT00253071 Not Applicable
30 The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels Completed NCT01385709
31 Blister Packaging Medication to Increase Treatment Adherence and Clinical Response Completed NCT01118208 Not Applicable
32 Home-based Transcranial Direct Current Stimulation in Fibromyalgia Patients Completed NCT02652988 Not Applicable
33 Transcranial Direct Current Stimulation Apparatus for Domiciliary Use Completed NCT02408237 Not Applicable
34 The Potential Efficacy of the Chinese Health Improvement Profile- A Pilot Clustered Randomised Controlled Trial Completed NCT02453217 Not Applicable
35 European Comparative Effectiveness Research on Internet-based Depression Treatment Completed NCT02542891 Not Applicable
36 Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) Completed NCT00012558 Not Applicable lithium;valproate;bupropion;paroxetine;lamotrigine;risperidone;inositol;tranylcypromine
37 Study of the Psychological Development of Children of Parents With and Without Affective Disorders Completed NCT00001170
38 Neurophysiologic Correlates of Hypersomnia Completed NCT01719315
39 Study of Sensorimotor Compatibility Effects in Bipolar Affective Disorder. Recruiting NCT03249857 Not Applicable
40 Evaluation of an App for Smartphones for People With a Bipolar Affective Disorder Recruiting NCT03275714 Not Applicable
41 Electronic Communication Augmented Mental Health Care Recruiting NCT03925038 Not Applicable
42 Evaluation of the Genetics of Bipolar Disorder Recruiting NCT00001174
43 Improving Work Outcome for People With Severe Mental Illness Active, not recruiting NCT01722344 Not Applicable
44 Somatic Comorbidities in Psychiatric Patients Active, not recruiting NCT02773108
45 A Study of Aerobic Exercise for Patients With Bipolar Disorder Not yet recruiting NCT03353337 Not Applicable
46 Cannabinoids in Bipolar Affective Disorder Withdrawn NCT00397605 Not Applicable Synthetic cannabinoids (1:1 ratio of THC % CBD)

Search NIH Clinical Center for Major Affective Disorder 2

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Major Affective Disorder 2

Anatomical Context for Major Affective Disorder 2

MalaCards organs/tissues related to Major Affective Disorder 2:

42
Bone, Eye, Ovary, Pituitary, Pancreas, Thyroid

Publications for Major Affective Disorder 2

Articles related to Major Affective Disorder 2:

# Title Authors Year
1
Clinical Practice Guidelines for Bipolar Affective Disorder (BPAD) in Children and Adolescents. ( 30745704 )
2019
2
Impact of Pharmacist-Psychiatrist Collaborative Patient Education on Medication Adherence and Quality of Life (QOL) of Bipolar Affective Disorder (BPAD) Patients. ( 29066976 )
2017
3
An apparently dominant bipolar affective disorder (BPAD) locus on chromosome 20p11.2-q11.2 in a large Turkish pedigree. ( 11175298 )
2001

Variations for Major Affective Disorder 2

Expression for Major Affective Disorder 2

Search GEO for disease gene expression data for Major Affective Disorder 2.

Pathways for Major Affective Disorder 2

GO Terms for Major Affective Disorder 2

Sources for Major Affective Disorder 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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