MDI
MCID: MJR008
MIFTS: 29

Major Affective Disorder 2 (MDI)

Categories: Genetic diseases, Mental diseases

Aliases & Classifications for Major Affective Disorder 2

MalaCards integrated aliases for Major Affective Disorder 2:

Name: Major Affective Disorder 2 57 12 13 73
Manic-Depressive Psychosis, X-Linked; Mdx 57
Manic-Depressive Psychosis, X-Linked 57
Bipolar Affective Disorder; Bpad 57
Manic-Depressive Illness; Mdi 57
Bipolar Affective Disorder 57
Manic-Depressive Illness 57
Bipolar Disorder 73
Mafd2 57
Bpad 57
Mdi 57
Mdx 57

Characteristics:

OMIM:

57
Inheritance:
? x-linked dominant vs. multifactorial


HPO:

32
major affective disorder 2:
Onset and clinical course infantile onset


Classifications:



External Ids:

OMIM 57 309200
Disease Ontology 12 DOID:0080221
MedGen 42 C1839839
SNOMED-CT via HPO 69 13746004

Summaries for Major Affective Disorder 2

MalaCards based summary : Major Affective Disorder 2, also known as manic-depressive psychosis, x-linked; mdx, is related to major affective disorder 1 and major affective disorder 4. An important gene associated with Major Affective Disorder 2 is MAFD2 (Major Affective Disorder 2). The drugs Lithium carbonate and Valproic Acid have been mentioned in the context of this disorder. Affiliated tissues include ovary, pancreas and thyroid, and related phenotype is bipolar affective disorder.

Description from OMIM: 309200

Related Diseases for Major Affective Disorder 2

Diseases in the Major Affective Disorder 1 family:

Major Affective Disorder 2 Major Affective Disorder 3
Major Affective Disorder 4 Major Affective Disorder 5
Major Affective Disorder 6 Major Affective Disorder 8
Major Affective Disorder 7 Major Affective Disorder 9

Diseases related to Major Affective Disorder 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 major affective disorder 1 12.0
2 major affective disorder 4 12.0
3 major affective disorder 5 12.0
4 major affective disorder 6 12.0
5 major affective disorder 3 11.5
6 major affective disorder 7 11.4
7 bipolar disorder 11.4
8 diabetes mellitus, permanent neonatal 11.1
9 diphenylmethane-4,4'-diisocyanate allergic asthma 11.1
10 diphenylmethane-4,4'-diisocyanate allergic contact dermatitis 11.1
11 perrault syndrome 1 11.1
12 muscular dystrophy 10.9
13 muscular dystrophy, duchenne type 10.9
14 schizophrenia 10.7
15 depression 10.4
16 major affective disorder 8 10.3
17 major affective disorder 9 10.3
18 color blindness 10.3
19 color vision deficiency 10.3
20 gas gangrene 10.3
21 dystrophinopathies 10.3
22 asthma 10.2
23 tardive dyskinesia 10.2
24 paranoid schizophrenia 10.2
25 multiple sclerosis 10.2
26 major depressive disorder 10.2
27 muscle hypertrophy 10.2
28 hypoxia 10.2
29 obsessive-compulsive disorder 10.1
30 personality disorder 10.1
31 extrinsic allergic alveolitis 10.1
32 influenza 10.1
33 viral infectious disease 10.1
34 thalassemia 10.1
35 dementia 10.1
36 endogenous depression 10.1
37 substance abuse 10.1
38 insulin-like growth factor i 10.1
39 polyglucosan body myopathy 1 with or without immunodeficiency 10.1
40 dilated cardiomyopathy 10.1
41 myotonia 10.1
42 graves disease 1 10.0
43 colorblindness, partial, deutan series 10.0
44 aceruloplasminemia 10.0
45 antisocial personality disorder 10.0
46 aseptic meningitis 10.0
47 meningitis 10.0
48 hypersomnia 10.0
49 frontotemporal dementia 10.0
50 alacrima, achalasia, and mental retardation syndrome 10.0

Graphical network of the top 20 diseases related to Major Affective Disorder 2:



Diseases related to Major Affective Disorder 2

Symptoms & Phenotypes for Major Affective Disorder 2

Symptoms via clinical synopsis from OMIM:

57
Neuro:
bipolar affective disorder

Misc:
early onset (before 30 years of age)


Clinical features from OMIM:

309200

Human phenotypes related to Major Affective Disorder 2:

32
# Description HPO Frequency HPO Source Accession
1 bipolar affective disorder 32 HP:0007302

Drugs & Therapeutics for Major Affective Disorder 2

Drugs for Major Affective Disorder 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lithium carbonate Approved Phase 4,Phase 3,Not Applicable 554-13-2
2
Valproic Acid Approved, Investigational Phase 4,Not Applicable 99-66-1 3121
3
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
4
Paroxetine Approved, Investigational Phase 4,Phase 3,Not Applicable 61869-08-7 43815
5
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
6 Tranquilizing Agents Phase 4,Phase 3,Phase 2,Not Applicable
7 Psychotropic Drugs Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
8 Antipsychotic Agents Phase 4,Phase 2,Not Applicable
9 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
10 Quetiapine Fumarate Phase 4 111974-72-2
11 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
12 Antidepressive Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
13 Antimanic Agents Phase 4,Phase 3,Not Applicable
14 GABA Agents Phase 4,Not Applicable
15 Anticonvulsants Phase 4,Phase 3,Phase 2,Not Applicable
16 Protective Agents Phase 4,Phase 2
17 Antioxidants Phase 4
18 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
19 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
20 Serotonin Agents Phase 4,Phase 3,Phase 2,Not Applicable
21 Serotonin Uptake Inhibitors Phase 4,Phase 3,Not Applicable
22 Antidepressive Agents, Second-Generation Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
23 Cytochrome P-450 CYP2D6 Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
24
Serotonin Investigational, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 50-67-9 5202
25
Lamotrigine Approved, Investigational Phase 3,Not Applicable 84057-84-1 3878
26
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
27
Dopamine Approved Phase 3,Phase 1,Phase 2,Not Applicable 51-61-6, 62-31-7 681
28 Diuretics, Potassium Sparing Phase 3,Not Applicable
29 Excitatory Amino Acid Antagonists Phase 3,Phase 2,Not Applicable
30 Sodium Channel Blockers Phase 3,Not Applicable
31 Calcium, Dietary Phase 3,Not Applicable
32 Excitatory Amino Acids Phase 3,Phase 2,Not Applicable
33 calcium channel blockers Phase 3,Not Applicable
34 Dopamine Uptake Inhibitors Phase 3,Phase 1,Phase 2,Not Applicable
35 Central Nervous System Stimulants Phase 3
36 Dopamine Agents Phase 3,Phase 1,Phase 2,Not Applicable
37
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
38
Tamoxifen Approved Phase 2 10540-29-1 2733526
39
Nicotine Approved Phase 1, Phase 2 54-11-5 942 89594
40
Bupropion Approved Phase 1, Phase 2,Not Applicable 34841-39-9, 34911-55-2 444
41
Ziprasidone Approved Phase 2 146939-27-7 60854
42
Riluzole Approved, Investigational Phase 2 1744-22-5 5070
43 Progestins Phase 2
44 Hormones Phase 2
45 Estrogens Phase 2
46 Estrogen Antagonists Phase 2
47 Selective Estrogen Receptor Modulators Phase 2
48 Estrogen Receptor Modulators Phase 2
49 Bone Density Conservation Agents Phase 2
50 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Efficacy and Safety of Flexible Dose of Quetiapine Fumarate (Seroquel) Switching From Other Drugs in the Treatment of Acute Manic Patients With Bipolar Disorder Unknown status NCT00837343 Phase 4 quetiapine fumarate tablet (Seroquel)
2 Transcranial Magnetic Stimulation in Bipolar Depression Completed NCT00186758 Phase 4
3 Aripiprazole in Late Life Bipolar Disorder Completed NCT00194038 Phase 4 Aripiprazole
4 Melatonin Versus Placebo for Benzodiazepine Discontinuation in Patients With Schizophrenia Completed NCT01431092 Phase 4 Placebo;Melatonin
5 Lithium Versus Paroxetine in Major Depression Completed NCT01416220 Phase 4 Lithium;Paroxetine
6 Safety Study of Depakote Versus Lithium in African Americans With Bipolar Disorder Withdrawn NCT01075126 Phase 4 Depakote;Lithium
7 Prophylactic Effect of Lamotrigine Compared With Lithium in Bipolar Disorder Completed NCT00226135 Phase 3 lithium or lamotrigine
8 Methylphenidate for the Treatment of Acute Mania Completed NCT01541605 Phase 3 methylphenidate;Placebo
9 Cannabidiol as an Adjunctive Treatment for Bipolar Depression Recruiting NCT03310593 Phase 2, Phase 3 Cannabidiol;Placebo
10 Lithium Versus Paroxetine in Patients With Major Depression Who Have a Family History of Bipolar Disorder or Suicide Terminated NCT00400088 Phase 3 paroxetine;lithium
11 rTMS in the Treatment of Bipolar Depression Unknown status NCT00436020 Phase 2
12 Anti-Estrogens - A Potential Treatment for Bipolar Affective Disorder in Women? Completed NCT00206544 Phase 2 Tamoxifen;Progesterone
13 A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Affective Disorder Completed NCT00593099 Phase 1, Phase 2 Bupropion;Placebo
14 Safety Study of Ziprasidone (Geodon) for the Depressive Mixed State Completed NCT00490542 Phase 2 ziprasidone (Geodon);placebo
15 Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar Disorder Terminated NCT00805493 Phase 2 Riluzole
16 Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder Withdrawn NCT00327756 Phase 2 Coenzyme Q10
17 Myths About Bipolar Affective Disorder: The Role of Structured Group Psychoeducation Therapy Unknown status NCT00474357 Not Applicable
18 Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder (PGBD) Unknown status NCT01272531 Mood stabilizer treatment
19 A Study of the Association Between Tobacco Smoking and Bipolar Affective Disorder Completed NCT00741299
20 Exercise for Depression Completed NCT02874833 Not Applicable
21 Bipolar Research Study Using MR Imaging Completed NCT02083978
22 Specialized Clozapine Clinic for Bipolar and Schizoaffective Disorder Completed NCT00683709
23 Bipolar Intervention Study: Cognitive Interpersonal Therapy Completed NCT01315028 Not Applicable
24 Genetic Aspects of Neurologic and Psychiatric Disorders Completed NCT00001544
25 Early Integrated Intervention in Severe Affective Disorders Completed NCT00253071 Not Applicable
26 The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels Completed NCT01385709
27 Blister Packaging Medication to Increase Treatment Adherence and Clinical Response Completed NCT01118208 Not Applicable
28 Home-based Transcranial Direct Current Stimulation in Fibromyalgia Patients Completed NCT02652988 Not Applicable
29 Transcranial Direct Current Stimulation Apparatus for Domiciliary Use Completed NCT02408237 Not Applicable
30 European Comparative Effectiveness Research on Internet-based Depression Treatment Completed NCT02542891 Not Applicable
31 Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) Completed NCT00012558 Not Applicable lithium;valproate;bupropion;paroxetine;lamotrigine;risperidone;inositol;tranylcypromine
32 Study of the Psychological Development of Children of Parents With and Without Affective Disorders Completed NCT00001170
33 Neurophysiologic Correlates of Hypersomnia Completed NCT01719315
34 Study of Sensorimotor Compatibility Effects in Bipolar Affective Disorder. Recruiting NCT03249857 Not Applicable
35 Evaluation of an App for Smartphones for People With a Bipolar Affective Disorder Recruiting NCT03275714 Not Applicable
36 Evaluation of the Genetics of Bipolar Disorder Recruiting NCT00001174
37 Improving Work Outcome for People With Severe Mental Illness Active, not recruiting NCT01722344 Not Applicable
38 Somatic Comorbidities in Psychiatric Patients Active, not recruiting NCT02773108
39 The Potential Efficacy of the Chinese Health Improvement Profile- A Pilot Clustered Randomised Controlled Trial Active, not recruiting NCT02453217 Not Applicable
40 A Study of Aerobic Exercise for Patients With Bipolar Disorder Not yet recruiting NCT03353337 Not Applicable
41 Psychiatric Disorders and Electrophysiological Markers Not yet recruiting NCT02329119 Not Applicable
42 Cannabinoids in Bipolar Affective Disorder Withdrawn NCT00397605 Not Applicable Synthetic cannabinoids (1:1 ratio of THC % CBD)

Search NIH Clinical Center for Major Affective Disorder 2

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Major Affective Disorder 2

Anatomical Context for Major Affective Disorder 2

MalaCards organs/tissues related to Major Affective Disorder 2:

41
Ovary, Pancreas, Thyroid

Publications for Major Affective Disorder 2

Articles related to Major Affective Disorder 2:

# Title Authors Year
1
Impact of Pharmacist-Psychiatrist Collaborative Patient Education on Medication Adherence and Quality of Life (QOL) of Bipolar Affective Disorder (BPAD) Patients. ( 29066976 )
2017
2
An apparently dominant bipolar affective disorder (BPAD) locus on chromosome 20p11.2-q11.2 in a large Turkish pedigree. ( 11175298 )
2001

Variations for Major Affective Disorder 2

Expression for Major Affective Disorder 2

Search GEO for disease gene expression data for Major Affective Disorder 2.

Pathways for Major Affective Disorder 2

GO Terms for Major Affective Disorder 2

Sources for Major Affective Disorder 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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