MCID: MJR008
MIFTS: 36

Major Affective Disorder 2

Categories: Mental diseases, Genetic diseases

Aliases & Classifications for Major Affective Disorder 2

MalaCards integrated aliases for Major Affective Disorder 2:

Name: Major Affective Disorder 2 57 12 13 73
Manic-Depressive Psychosis, X-Linked; Mdx 57
Manic-Depressive Psychosis, X-Linked 57
Bipolar Affective Disorder; Bpad 57
Manic-Depressive Illness; Mdi 57
Bipolar Affective Disorder 57
Manic-Depressive Illness 57
Bipolar Disorder 73
Mafd2 57
Bpad 57
Mdi 57
Mdx 57

Characteristics:

OMIM:

57
Inheritance:
? x-linked dominant vs. multifactorial


HPO:

32
major affective disorder 2:
Onset and clinical course infantile onset


Classifications:



External Ids:

OMIM 57 309200
Disease Ontology 12 DOID:0080221
MedGen 42 C1839839
SNOMED-CT via HPO 69 13746004
UMLS 73 C1839839

Summaries for Major Affective Disorder 2

MalaCards based summary : Major Affective Disorder 2, also known as manic-depressive psychosis, x-linked; mdx, is related to major affective disorder 1 and major affective disorder 4. An important gene associated with Major Affective Disorder 2 is MAFD2 (Major Affective Disorder 2). The drugs Valproic Acid and Aripiprazole have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and testes, and related phenotype is bipolar affective disorder.

Description from OMIM: 309200

Related Diseases for Major Affective Disorder 2

Graphical network of the top 20 diseases related to Major Affective Disorder 2:



Diseases related to Major Affective Disorder 2

Symptoms & Phenotypes for Major Affective Disorder 2

Symptoms via clinical synopsis from OMIM:

57
Misc:
early onset (before 30 years of age)

Neuro:
bipolar affective disorder


Clinical features from OMIM:

309200

Human phenotypes related to Major Affective Disorder 2:

32
# Description HPO Frequency HPO Source Accession
1 bipolar affective disorder 32 HP:0007302

Drugs & Therapeutics for Major Affective Disorder 2

Drugs for Major Affective Disorder 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Valproic Acid Approved, Investigational Phase 4,Not Applicable 99-66-1 3121
2
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
3
Paroxetine Approved, Investigational Phase 4,Phase 3,Not Applicable 61869-08-7 43815
4
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
5 Antipsychotic Agents Phase 4,Phase 2,Not Applicable
6 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
7 Psychotropic Drugs Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
8 Quetiapine Fumarate Phase 4 111974-72-2
9 Tranquilizing Agents Phase 4,Phase 3,Phase 2,Not Applicable
10 Antidepressive Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
11 Antimanic Agents Phase 4,Phase 3,Not Applicable
12 Lithium carbonate Phase 4,Phase 3,Not Applicable 554-13-2
13 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
14 Anticonvulsants Phase 4,Phase 3,Phase 2,Not Applicable
15 GABA Agents Phase 4,Not Applicable
16 Antioxidants Phase 4
17 Protective Agents Phase 4,Phase 2
18 Antidepressive Agents, Second-Generation Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
19 Cytochrome P-450 CYP2D6 Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
20 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
21 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
22 Serotonin Agents Phase 4,Phase 3,Phase 2,Not Applicable
23 Serotonin Uptake Inhibitors Phase 4,Phase 3,Not Applicable
24
Serotonin Investigational, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 50-67-9 5202
25
Lamotrigine Approved, Investigational Phase 3,Not Applicable 84057-84-1 3878
26
Dopamine Approved Phase 3,Phase 1,Phase 2,Not Applicable 51-61-6, 62-31-7 681
27
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
28 calcium channel blockers Phase 3,Not Applicable
29 Calcium, Dietary Phase 3,Not Applicable
30 Diuretics, Potassium Sparing Phase 3,Not Applicable
31 Excitatory Amino Acid Antagonists Phase 3,Phase 2,Not Applicable
32 Excitatory Amino Acids Phase 3,Phase 2,Not Applicable
33 Sodium Channel Blockers Phase 3,Not Applicable
34 Central Nervous System Stimulants Phase 3
35 Dopamine Agents Phase 3,Phase 1,Phase 2,Not Applicable
36 Dopamine Uptake Inhibitors Phase 3,Phase 1,Phase 2,Not Applicable
37
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
38
Tamoxifen Approved Phase 2 10540-29-1 2733526
39
Bupropion Approved Phase 1, Phase 2,Not Applicable 34841-39-9, 34911-55-2 444
40
Nicotine Approved Phase 1, Phase 2 54-11-5 942 89594
41
Ziprasidone Approved Phase 2 146939-27-7 60854
42
Riluzole Approved, Investigational Phase 2 1744-22-5 5070
43 Antineoplastic Agents, Hormonal Phase 2
44 Bone Density Conservation Agents Phase 2
45 Estrogen Antagonists Phase 2
46 Estrogen Receptor Modulators Phase 2
47 Estrogens Phase 2
48 Hormone Antagonists Phase 2
49 Hormones Phase 2
50 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Efficacy and Safety of Flexible Dose of Quetiapine Fumarate (Seroquel) Switching From Other Drugs in the Treatment of Acute Manic Patients With Bipolar Disorder Unknown status NCT00837343 Phase 4 quetiapine fumarate tablet (Seroquel)
2 Transcranial Magnetic Stimulation in Bipolar Depression Completed NCT00186758 Phase 4
3 Aripiprazole in Late Life Bipolar Disorder Completed NCT00194038 Phase 4 Aripiprazole
4 Melatonin Versus Placebo for Benzodiazepine Discontinuation in Patients With Schizophrenia Completed NCT01431092 Phase 4 Placebo;Melatonin
5 Lithium Versus Paroxetine in Major Depression Completed NCT01416220 Phase 4 Lithium;Paroxetine
6 Safety Study of Depakote Versus Lithium in African Americans With Bipolar Disorder Withdrawn NCT01075126 Phase 4 Depakote;Lithium
7 Prophylactic Effect of Lamotrigine Compared With Lithium in Bipolar Disorder Completed NCT00226135 Phase 3 lithium or lamotrigine
8 Methylphenidate for the Treatment of Acute Mania Completed NCT01541605 Phase 3 methylphenidate;Placebo
9 Cannabidiol as an Adjunctive Treatment for Bipolar Depression Recruiting NCT03310593 Phase 2, Phase 3 Cannabidiol;Placebo
10 Lithium Versus Paroxetine in Patients With Major Depression Who Have a Family History of Bipolar Disorder or Suicide Terminated NCT00400088 Phase 3 paroxetine;lithium
11 rTMS in the Treatment of Bipolar Depression Unknown status NCT00436020 Phase 2
12 Anti-Estrogens - A Potential Treatment for Bipolar Affective Disorder in Women? Completed NCT00206544 Phase 2 Tamoxifen;Progesterone
13 A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Affective Disorder Completed NCT00593099 Phase 1, Phase 2 Bupropion;Placebo
14 Safety Study of Ziprasidone (Geodon) for the Depressive Mixed State Completed NCT00490542 Phase 2 ziprasidone (Geodon);placebo
15 Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar Disorder Terminated NCT00805493 Phase 2 Riluzole
16 Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder Withdrawn NCT00327756 Phase 2 Coenzyme Q10
17 Myths About Bipolar Affective Disorder: The Role of Structured Group Psychoeducation Therapy Unknown status NCT00474357 Not Applicable
18 Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder (PGBD) Unknown status NCT01272531 Mood stabilizer treatment
19 Neurophysiologic Correlates of Hypersomnia Unknown status NCT01719315
20 A Study of the Association Between Tobacco Smoking and Bipolar Affective Disorder Completed NCT00741299
21 Exercise for Depression Completed NCT02874833 Not Applicable
22 Bipolar Research Study Using MR Imaging Completed NCT02083978
23 Specialized Clozapine Clinic for Bipolar and Schizoaffective Disorder Completed NCT00683709
24 Bipolar Intervention Study: Cognitive Interpersonal Therapy Completed NCT01315028 Not Applicable
25 Genetic Aspects of Neurologic and Psychiatric Disorders Completed NCT00001544
26 Early Integrated Intervention in Severe Affective Disorders Completed NCT00253071 Not Applicable
27 The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels Completed NCT01385709
28 Blister Packaging Medication to Increase Treatment Adherence and Clinical Response Completed NCT01118208 Not Applicable
29 Transcranial Direct Current Stimulation Apparatus for Domiciliary Use Completed NCT02408237 Not Applicable
30 European Comparative Effectiveness Research on Internet-based Depression Treatment Completed NCT02542891 Not Applicable
31 Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) Completed NCT00012558 Not Applicable lithium;valproate;bupropion;paroxetine;lamotrigine;risperidone;inositol;tranylcypromine
32 Study of the Psychological Development of Children of Parents With and Without Affective Disorders Completed NCT00001170
33 Study of Sensorimotor Compatibility Effects in Bipolar Affective Disorder. Recruiting NCT03249857 Not Applicable
34 Evaluation of an App for Smartphones for People With a Bipolar Affective Disorder Recruiting NCT03275714 Not Applicable
35 Home-based Transcranial Direct Current Stimulation in Fibromyalgia Patients Recruiting NCT02652988 Not Applicable
36 Evaluation of the Genetics of Bipolar Disorder Recruiting NCT00001174
37 Improving Work Outcome for People With Severe Mental Illness Active, not recruiting NCT01722344 Not Applicable
38 Somatic Comorbidities in Psychiatric Patients Active, not recruiting NCT02773108
39 The Potential Efficacy of the Chinese Health Improvement Profile- A Pilot Clustered Randomised Controlled Trial Active, not recruiting NCT02453217 Not Applicable
40 A Study of Aerobic Exercise for Patients With Bipolar Disorder Not yet recruiting NCT03353337 Not Applicable
41 Psychiatric Disorders and Electrophysiological Markers Not yet recruiting NCT02329119 Not Applicable
42 Cannabinoids in Bipolar Affective Disorder Withdrawn NCT00397605 Not Applicable Synthetic cannabinoids (1:1 ratio of THC % CBD)

Search NIH Clinical Center for Major Affective Disorder 2

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Major Affective Disorder 2

Anatomical Context for Major Affective Disorder 2

MalaCards organs/tissues related to Major Affective Disorder 2:

41
Brain, Bone, Testes, Cortex, Amygdala, Ovary, Prefrontal Cortex

Publications for Major Affective Disorder 2

Articles related to Major Affective Disorder 2:

(show top 50) (show all 257)
# Title Authors Year
1
Polycystic Ovary Syndrome in Bipolar Affective Disorder: A Hospital-based Study. ( 29962567 )
2018
2
Polydipsia as a Precursor of Manic Episode in Bipolar Affective Disorder Patients with Alcohol Use Disorder. ( 29397674 )
2018
3
A Rare Presentation of a Case of Obsessive-compulsive Disorder Comorbid with Bipolar Affective Disorder. ( 29284814 )
2017
4
Predictors of rehospitalization in a naturalistic cohort of patients with bipolar affective disorder. ( 28207568 )
2017
5
Soluble Intracellular Adhesion Molecule-1 in Patients with Unipolar or Bipolar Affective Disorders: Results from a Pilot Trial. ( 27442531 )
2016
6
DGKH genetic risk variant influences gene expression in bipolar affective disorder. ( 27016658 )
2016
7
Comparative neuropsychiatry: white matter abnormalities in children and adolescents with schizophrenia, bipolar affective disorder, and obsessive-compulsive disorder. ( 25498242 )
2015
8
Frontotemporal dementia mimicking bipolar affective disorder, normal pressure hydrocephalus and KlA1ver-Bucy syndrome. ( 26482719 )
2015
9
Influence of DGKH variants on amygdala volume in patients with bipolar affective disorder and schizophrenia. ( 24958494 )
2015
10
Fluctuating capacity and advance decision-making in Bipolar Affective Disorder - Self-binding directives and self-determination. ( 25939286 )
2015
11
Pharmacotherapy of Bipolar Affective Disorder: A Hospital based Study from Sub Himalayan Valley of Nepal. ( 25121003 )
2014
12
Disruption of sonic hedgehog signaling in Ellis-van Creveld dwarfism confers protection against bipolar affective disorder. ( 25311364 )
2014
13
Brain-derived neurotrophic factor (BDNF)-epigenetic regulation in unipolar and bipolar affective disorder. ( 25106037 )
2014
14
De novo CNVs in bipolar affective disorder and schizophrenia. ( 25055870 )
2014
15
Analysis of genetic association and epistasis interactions between circadian clock genes and symptom dimensions of bipolar affective disorder. ( 24673294 )
2014
16
Association analysis of genes in serotonin pathway with attention and executive function in patients with bipolar affective disorder. ( 25200194 )
2014
17
Olanzapine-induced neuroleptic malignant syndrome in a patient with bipolar affective disorder: Does quetiapine holds the solution? ( 25013321 )
2013
18
Contribution of methotrexate in precipitation of manic episode in bipolar affective disorder explored: a case report. ( 24167698 )
2013
19
Can we prevent under-diagnosis and misdiagnosis of bipolar affective disorder? Repeat audits to assess the epidemiological change in the caseload of a community mental health team when bipolar disorder is accurately assessed and diagnosed. ( 23995161 )
2013
20
[Cognitive functioning in depression and the course of bipolar affective disorder]. ( 23888758 )
2013
21
No association between serum cholesterol and death by suicide in patients with schizophrenia, bipolar affective disorder, or major depressive disorder. ( 24308827 )
2013
22
Bipolar affective disorder preceding frontotemporal dementia in a patient with C9ORF72 mutation: is there a genetic link between these two disorders? ( 23314407 )
2013
23
A case of bipolar affective disorder and aspiration pneumonia. ( 23956911 )
2013
24
Sodium Valproate induced priapism in an adult with bipolar affective disorder. ( 24347777 )
2013
25
Mental state deterioration after switching from brand-name to generic olanzapine in an adolescent with bipolar affective disorder, autism and intellectual disability: a case study. ( 24094081 )
2013
26
Bipolar affective disorder and early dementia onset in a male patient with SHANK3 deletion. ( 22922660 )
2012
27
Replication of functional serotonin receptor type 3A and B variants in bipolar affective disorder: a European multicenter study. ( 22832903 )
2012
28
A follow-up study of family burden in patients with bipolar affective disorder. ( 21421638 )
2012
29
Borderline personality disorder and bipolar affective disorder. Spectra or spectre? A review. ( 22508593 )
2012
30
Analysis of association between common SNPs in ErbB4 and bipolar affective disorder, major depressive disorder and schizophrenia in the Han Chinese population. ( 21993442 )
2012
31
Differential diagnosis of bipolar affective disorder type II and borderline personality disorder: analysis of the affective dimension. ( 22560773 )
2012
32
Tests of linkage and allelic association between markers in the 1p36 PRKCZ (protein kinase C zeta) gene region and bipolar affective disorder. ( 22231931 )
2012
33
Quinacrine induced mood disturbance--the unmasking of bipolar affective disorder. ( 22729334 )
2012
34
Gender-specific association of TSNAX/DISC1 locus for schizophrenia and bipolar affective disorder in South Indian population. ( 22673686 )
2012
35
Carbamazepine-induced erythema multiforme major in an epileptic patient with bipolar affective disorder. ( 22629103 )
2012
36
Haloperidol induced obsessive compulsive symptom (OCS) in a patient with learning disability and bipolar affective disorder. ( 22605593 )
2012
37
Atypical presentation of tardive dyskinesia associated with risperidone long-acting injection as maintenance treatment in bipolar affective disorder: a case report. ( 22663952 )
2012
38
Comorbid bipolar affective disorder and obsessive compulsive disorder in childhood: a case study and brief review. ( 23440037 )
2012
39
MAGI1 copy number variation in bipolar affective disorder and schizophrenia. ( 22381734 )
2012
40
Development of frontotemporal dementia in a case of bipolar affective disorder: is there a link? ( 22714610 )
2011
41
Cognitions in bipolar affective disorder and unipolar depression: imagining suicide. ( 22085478 )
2011
42
Genetic association and sequencing of the insulin-like growth factor 1 gene in bipolar affective disorder. ( 21302346 )
2011
43
Chronic somatic comorbidity and excess mortality due to natural causes in persons with schizophrenia or bipolar affective disorder. ( 21935426 )
2011
44
The seasonality of bipolar affective disorder: comparison with a primary care sample using the Seasonal Pattern Assessment Questionnaire. ( 21377212 )
2011
45
A systematic association mapping on chromosome 6q in bipolar affective disorder--evidence for the melanin-concentrating-hormone-receptor-2 gene as a risk factor for bipolar affective disorder. ( 19927306 )
2010
46
Nuclear receptor rev-erb-{alpha} circadian gene variants and lithium carbonate prophylaxis in bipolar affective disorder. ( 20348464 )
2010
47
Support for a bipolar affective disorder susceptibility locus on chromosome 12q24.3. ( 20410851 )
2010
48
Effect of fasting during Ramadan on serum lithium level and mental state in bipolar affective disorder. ( 20827213 )
2010
49
Midline brain abnormalities in established bipolar affective disorder. ( 19782407 )
2010
50
Autonomic nervous system in euthymic patients with bipolar affective disorder. ( 21196931 )
2010

Variations for Major Affective Disorder 2

Expression for Major Affective Disorder 2

Search GEO for disease gene expression data for Major Affective Disorder 2.

Pathways for Major Affective Disorder 2

GO Terms for Major Affective Disorder 2

Sources for Major Affective Disorder 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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