MDI
MCID: MJR008
MIFTS: 31

Major Affective Disorder 2 (MDI)

Categories: Genetic diseases, Mental diseases

Aliases & Classifications for Major Affective Disorder 2

MalaCards integrated aliases for Major Affective Disorder 2:

Name: Major Affective Disorder 2 58 12 13 74
Manic-Depressive Psychosis, X-Linked; Mdx 58
Manic-Depressive Psychosis, X-Linked 58
Bipolar Affective Disorder; Bpad 58
Manic-Depressive Illness; Mdi 58
Bipolar Affective Disorder 58
Manic-Depressive Illness 58
Bipolar Disorder 74
Mafd2 58
Bpad 58
Mdi 58
Mdx 58

Characteristics:

OMIM:

58
Inheritance:
? x-linked dominant vs. multifactorial


HPO:

33
major affective disorder 2:
Onset and clinical course infantile onset


Classifications:



External Ids:

Disease Ontology 12 DOID:0080221
OMIM 58 309200
MedGen 43 C1839839
SNOMED-CT via HPO 70 13746004

Summaries for Major Affective Disorder 2

MalaCards based summary : Major Affective Disorder 2, also known as manic-depressive psychosis, x-linked; mdx, is related to major affective disorder 1 and major affective disorder 4. An important gene associated with Major Affective Disorder 2 is MAFD2 (Major Affective Disorder 2). The drugs Lithium carbonate and Valproic Acid have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotype is bipolar affective disorder.

Description from OMIM: 309200

Related Diseases for Major Affective Disorder 2

Diseases in the Major Affective Disorder 7 family:

Major Affective Disorder 1 Major Affective Disorder 2
Major Affective Disorder 3 Major Affective Disorder 4
Major Affective Disorder 5 Major Affective Disorder 6
Major Affective Disorder 8 Major Affective Disorder 9

Diseases related to Major Affective Disorder 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 major affective disorder 1 12.0
2 major affective disorder 4 12.0
3 major affective disorder 5 12.0
4 major affective disorder 6 12.0
5 major affective disorder 3 11.5
6 major affective disorder 7 11.4
7 bipolar disorder 11.4
8 diabetes mellitus, permanent neonatal 11.2
9 diphenylmethane-4,4'-diisocyanate allergic asthma 11.1
10 diphenylmethane-4,4'-diisocyanate allergic contact dermatitis 11.1
11 perrault syndrome 1 11.1
12 muscular dystrophy 11.0
13 muscular dystrophy, duchenne type 10.9
14 schizophrenia 10.8
15 depression 10.5
16 major affective disorder 8 10.4
17 major affective disorder 9 10.4
18 color blindness 10.3
19 color vision deficiency 10.3
20 insulin-like growth factor i 10.2
21 gas gangrene 10.2
22 dystrophinopathies 10.2
23 asthma 10.2
24 tardive dyskinesia 10.2
25 personality disorder 10.2
26 muscle hypertrophy 10.2
27 graves disease 1 10.2
28 paranoid schizophrenia 10.2
29 multiple sclerosis 10.2
30 major depressive disorder 10.2
31 obsessive-compulsive disorder 10.1
32 disease of mental health 10.1
33 hypoxia 10.1
34 thalassemia 10.1
35 dementia 10.1
36 endogenous depression 10.1
37 substance abuse 10.1
38 diabetes mellitus 10.1
39 extrinsic allergic alveolitis 10.1
40 influenza 10.1
41 polyglucosan body myopathy 1 with or without immunodeficiency 10.0
42 dilated cardiomyopathy 10.0
43 myopathy 10.0
44 myotonia 10.0
45 prader-willi syndrome 10.0
46 fragile x syndrome 10.0
47 colorblindness, partial, deutan series 10.0
48 aceruloplasminemia 10.0
49 antisocial personality disorder 10.0
50 aseptic meningitis 10.0

Graphical network of the top 20 diseases related to Major Affective Disorder 2:



Diseases related to Major Affective Disorder 2

Symptoms & Phenotypes for Major Affective Disorder 2

Human phenotypes related to Major Affective Disorder 2:

33
# Description HPO Frequency HPO Source Accession
1 bipolar affective disorder 33 HP:0007302

Symptoms via clinical synopsis from OMIM:

58
Neuro:
bipolar affective disorder

Misc:
early onset (before 30 years of age)

Clinical features from OMIM:

309200

Drugs & Therapeutics for Major Affective Disorder 2

Drugs for Major Affective Disorder 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 94)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lithium carbonate Approved Phase 4,Phase 3,Not Applicable 554-13-2
2
Valproic Acid Approved, Investigational Phase 4,Not Applicable 99-66-1 3121
3
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
4
Dopamine Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 62-31-7, 51-61-6 681
5
Succinylcholine Approved Phase 4 306-40-1 5314
6
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
7
Paroxetine Approved, Investigational Phase 4,Phase 3,Not Applicable 61869-08-7 43815
8
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
9
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
10 Antidepressive Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
11 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
12 Psychotropic Drugs Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
13 Quetiapine Fumarate Phase 4 111974-72-2
14 Antipsychotic Agents Phase 4,Phase 3,Phase 2,Not Applicable
15 Tranquilizing Agents Phase 4,Phase 3,Phase 2,Not Applicable
16 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
17 Antimanic Agents Phase 4,Phase 3,Not Applicable
18 Anticonvulsants Phase 4,Phase 3,Phase 2,Not Applicable
19 GABA Agents Phase 4,Not Applicable
20 Dopamine Antagonists Phase 4,Phase 2,Not Applicable
21 Serotonin 5-HT2 Receptor Antagonists Phase 4
22 Serotonin Agents Phase 4,Phase 3,Phase 2,Not Applicable
23 Serotonin Antagonists Phase 4,Phase 2,Not Applicable
24 Dopamine agonists Phase 4
25 Dopamine D2 Receptor Antagonists Phase 4
26 Serotonin 5-HT1 Receptor Agonists Phase 4
27 Serotonin Receptor Agonists Phase 4
28 Dopamine Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
29 Antioxidants Phase 4
30 Protective Agents Phase 4,Phase 2
31 Hypnotics and Sedatives Phase 4
32 Anesthetics, General Phase 4
33 Anesthetics, Intravenous Phase 4
34 Anesthetics Phase 4
35 Antidepressive Agents, Second-Generation Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
36 Serotonin Uptake Inhibitors Phase 4,Phase 3,Not Applicable
37 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
38 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
39 Cytochrome P-450 CYP2D6 Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
40 Analgesics Phase 4
41 Excitatory Amino Acids Phase 4,Phase 2
42 Excitatory Amino Acid Antagonists Phase 4,Phase 2
43 Peripheral Nervous System Agents Phase 4
44 Anesthetics, Dissociative Phase 4
45
Serotonin Investigational, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 50-67-9 5202
46
Lamotrigine Approved, Investigational Phase 3,Not Applicable 84057-84-1 3878
47
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
48
Calcium Approved, Nutraceutical Phase 3,Not Applicable 7440-70-2 271
49 Calcium, Dietary Phase 3,Not Applicable
50 Diuretics, Potassium Sparing Phase 3,Not Applicable

Interventional clinical trials:

(show all 44)
# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Efficacy and Safety of Flexible Dose of Quetiapine Fumarate (Seroquel) Switching From Other Drugs in the Treatment of Acute Manic Patients With Bipolar Disorder Unknown status NCT00837343 Phase 4 quetiapine fumarate tablet (Seroquel)
2 Transcranial Magnetic Stimulation in Bipolar Depression Completed NCT00186758 Phase 4
3 Aripiprazole in Late Life Bipolar Disorder Completed NCT00194038 Phase 4 Aripiprazole
4 Melatonin Versus Placebo for Benzodiazepine Discontinuation in Patients With Schizophrenia Completed NCT01431092 Phase 4 Placebo;Melatonin
5 Comparison of Propofol Target-Controlled Infusion Anesthesia and Bolus Injection in Electroconvulsive Therapy Completed NCT03863925 Phase 4
6 Lithium Versus Paroxetine in Major Depression Completed NCT01416220 Phase 4 Lithium;Paroxetine
7 Comparison of Ketamine Combine Propofol vs Propofol Anesthesia in Schizophrenia Electroconvulsive Therapy Not yet recruiting NCT03829124 Phase 4 Propofol;Ketamine
8 Safety Study of Depakote Versus Lithium in African Americans With Bipolar Disorder Withdrawn NCT01075126 Phase 4 Depakote;Lithium
9 Prophylactic Effect of Lamotrigine Compared With Lithium in Bipolar Disorder Completed NCT00226135 Phase 3 lithium or lamotrigine
10 Methylphenidate for the Treatment of Acute Mania Completed NCT01541605 Phase 3 methylphenidate;Placebo
11 Cannabidiol as an Adjunctive Treatment for Bipolar Depression Recruiting NCT03310593 Phase 2, Phase 3 Cannabidiol;Placebo
12 Lithium Versus Paroxetine in Patients With Major Depression Who Have a Family History of Bipolar Disorder or Suicide Terminated NCT00400088 Phase 3 paroxetine;lithium
13 rTMS in the Treatment of Bipolar Depression Unknown status NCT00436020 Phase 2
14 Anti-Estrogens - A Potential Treatment for Bipolar Affective Disorder in Women? Completed NCT00206544 Phase 2 Tamoxifen;Progesterone
15 A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Affective Disorder Completed NCT00593099 Phase 1, Phase 2 Bupropion;Placebo
16 Safety Study of Ziprasidone (Geodon) for the Depressive Mixed State Completed NCT00490542 Phase 2 ziprasidone (Geodon);placebo
17 Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar Disorder Terminated NCT00805493 Phase 2 Riluzole
18 Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder Withdrawn NCT00327756 Phase 2 Coenzyme Q10
19 Myths About Bipolar Affective Disorder: The Role of Structured Group Psychoeducation Therapy Unknown status NCT00474357 Not Applicable
20 Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder (PGBD) Unknown status NCT01272531 Mood stabilizer treatment
21 Psychiatric Disorders and Electrophysiological Markers Unknown status NCT02329119 Not Applicable
22 A Study of the Association Between Tobacco Smoking and Bipolar Affective Disorder Completed NCT00741299
23 Exercise for Depression Completed NCT02874833 Not Applicable
24 Bipolar Research Study Using MR Imaging Completed NCT02083978
25 Specialized Clozapine Clinic for Bipolar and Schizoaffective Disorder Completed NCT00683709
26 Bipolar Intervention Study: Cognitive Interpersonal Therapy Completed NCT01315028 Not Applicable
27 Genetic Aspects of Neurologic and Psychiatric Disorders Completed NCT00001544
28 Early Integrated Intervention in Severe Affective Disorders Completed NCT00253071 Not Applicable
29 The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels Completed NCT01385709
30 Blister Packaging Medication to Increase Treatment Adherence and Clinical Response Completed NCT01118208 Not Applicable
31 Home-based Transcranial Direct Current Stimulation in Fibromyalgia Patients Completed NCT02652988 Not Applicable
32 Transcranial Direct Current Stimulation Apparatus for Domiciliary Use Completed NCT02408237 Not Applicable
33 The Potential Efficacy of the Chinese Health Improvement Profile- A Pilot Clustered Randomised Controlled Trial Completed NCT02453217 Not Applicable
34 European Comparative Effectiveness Research on Internet-based Depression Treatment Completed NCT02542891 Not Applicable
35 Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) Completed NCT00012558 Not Applicable lithium;valproate;bupropion;paroxetine;lamotrigine;risperidone;inositol;tranylcypromine
36 Study of the Psychological Development of Children of Parents With and Without Affective Disorders Completed NCT00001170
37 Neurophysiologic Correlates of Hypersomnia Completed NCT01719315
38 Study of Sensorimotor Compatibility Effects in Bipolar Affective Disorder. Recruiting NCT03249857 Not Applicable
39 Evaluation of an App for Smartphones for People With a Bipolar Affective Disorder Recruiting NCT03275714 Not Applicable
40 Evaluation of the Genetics of Bipolar Disorder Recruiting NCT00001174
41 Improving Work Outcome for People With Severe Mental Illness Active, not recruiting NCT01722344 Not Applicable
42 Somatic Comorbidities in Psychiatric Patients Active, not recruiting NCT02773108
43 A Study of Aerobic Exercise for Patients With Bipolar Disorder Not yet recruiting NCT03353337 Not Applicable
44 Cannabinoids in Bipolar Affective Disorder Withdrawn NCT00397605 Not Applicable Synthetic cannabinoids (1:1 ratio of THC % CBD)

Search NIH Clinical Center for Major Affective Disorder 2

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Major Affective Disorder 2

Anatomical Context for Major Affective Disorder 2

MalaCards organs/tissues related to Major Affective Disorder 2:

42
Bone

Publications for Major Affective Disorder 2

Articles related to Major Affective Disorder 2:

# Title Authors Year
1
Clinical Practice Guidelines for Bipolar Affective Disorder (BPAD) in Children and Adolescents. ( 30745704 )
2019
2
Impact of Pharmacist-Psychiatrist Collaborative Patient Education on Medication Adherence and Quality of Life (QOL) of Bipolar Affective Disorder (BPAD) Patients. ( 29066976 )
2017
3
An apparently dominant bipolar affective disorder (BPAD) locus on chromosome 20p11.2-q11.2 in a large Turkish pedigree. ( 11175298 )
2001

Variations for Major Affective Disorder 2

Expression for Major Affective Disorder 2

Search GEO for disease gene expression data for Major Affective Disorder 2.

Pathways for Major Affective Disorder 2

GO Terms for Major Affective Disorder 2

Sources for Major Affective Disorder 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....