MAFD4
MCID: MJR004
MIFTS: 29

Major Affective Disorder 4 (MAFD4)

Categories: Genetic diseases, Mental diseases

Aliases & Classifications for Major Affective Disorder 4

MalaCards integrated aliases for Major Affective Disorder 4:

Name: Major Affective Disorder 4 58 13 74
Bipolar Affective Disorder; Bpad 58
Bipolar Affective Disorder 58
Bipolar Disorder 74
Mafd4 58
Bpad 58

Classifications:



External Ids:

OMIM 58 611247
MedGen 43 C1970943

Summaries for Major Affective Disorder 4

MalaCards based summary : Major Affective Disorder 4, also known as bipolar affective disorder; bpad, is related to bipolar disorder and major affective disorder 1. An important gene associated with Major Affective Disorder 4 is MAFD4 (Major Affective Disorder 4). The drugs Valproic Acid and Lithium carbonate have been mentioned in the context of this disorder. Affiliated tissues include bone, ovary and pituitary.

Description from OMIM: 611247

Related Diseases for Major Affective Disorder 4

Diseases in the Major Affective Disorder 1 family:

Major Affective Disorder 2 Major Affective Disorder 3
Major Affective Disorder 4 Major Affective Disorder 5
Major Affective Disorder 6 Major Affective Disorder 8
Major Affective Disorder 7 Major Affective Disorder 9

Diseases related to Major Affective Disorder 4 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 bipolar disorder 12.1
2 major affective disorder 1 12.0
3 major affective disorder 2 12.0
4 major affective disorder 5 12.0
5 major affective disorder 6 12.0
6 major affective disorder 3 11.5
7 cone-rod dystrophy and hearing loss 2 11.1
8 schizophrenia 10.7
9 depression 10.4
10 major affective disorder 8 10.4
11 major affective disorder 7 10.4
12 major affective disorder 9 10.4
13 tardive dyskinesia 10.2
14 personality disorder 10.2
15 multiple sclerosis 10.2
16 obsessive-compulsive disorder 10.2
17 major depressive disorder 10.2
18 disease of mental health 10.1
19 endogenous depression 10.1
20 thalassemia 10.1
21 dementia 10.1
22 substance abuse 10.1
23 frontotemporal dementia 10.0
24 alacrima, achalasia, and mental retardation syndrome 10.0
25 borderline personality disorder 10.0
26 hypothyroidism 10.0
27 mental depression 10.0
28 head injury 10.0
29 autism 9.9
30 orthostatic intolerance 9.9
31 beta-thalassemia 9.9
32 hydrocephalus 9.9
33 conn's syndrome 9.9
34 schizoaffective disorder 9.9
35 adenoma 9.9
36 periodontitis 9.9
37 cyclothymic disorder 9.9
38 learning disability 9.9
39 congenital hydrocephalus 9.9
40 darier-white disease 9.8
41 huntington disease 9.8
42 jacobsen syndrome 9.8
43 klippel-trenaunay-weber syndrome 9.8
44 lithium transport 9.8
45 mccune-albright syndrome 9.8
46 pulmonary fibrosis, idiopathic 9.8
47 schizophrenia 1 9.8
48 cerebrotendinous xanthomatosis 9.8
49 wolfram syndrome 1 9.8
50 hydrocephalus, normal-pressure 9.8

Graphical network of the top 20 diseases related to Major Affective Disorder 4:



Diseases related to Major Affective Disorder 4

Symptoms & Phenotypes for Major Affective Disorder 4

Clinical features from OMIM:

611247

Drugs & Therapeutics for Major Affective Disorder 4

Drugs for Major Affective Disorder 4 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
2
Lithium carbonate Approved Phase 4,Phase 3 554-13-2
3
Succinylcholine Approved Phase 4 306-40-1 5314
4
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
5
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
6
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
7 Tranquilizing Agents Phase 4,Phase 3
8 Psychotropic Drugs Phase 4,Phase 3,Phase 1,Phase 2
9 Antidepressive Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
10 Central Nervous System Depressants Phase 4,Phase 3
11 Quetiapine Fumarate Phase 4 111974-72-2
12 Antipsychotic Agents Phase 4,Phase 3
13 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2
14 GABA Agents Phase 4
15 Antimanic Agents Phase 4,Phase 3
16 Anticonvulsants Phase 4,Phase 3,Phase 2
17 Antioxidants Phase 4
18 Protective Agents Phase 4,Phase 2
19 Anesthetics, Intravenous Phase 4
20 Hypnotics and Sedatives Phase 4
21 Anesthetics, General Phase 4
22 Anesthetics Phase 4
23 Excitatory Amino Acid Antagonists Phase 4,Phase 2
24 Peripheral Nervous System Agents Phase 4
25 Anesthetics, Dissociative Phase 4
26 Analgesics Phase 4
27 Excitatory Amino Acids Phase 4,Phase 2
28
Lamotrigine Approved, Investigational Phase 3 84057-84-1 3878
29
Dopamine Approved Phase 3,Phase 1,Phase 2 62-31-7, 51-61-6 681
30
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
31
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
32 calcium channel blockers Phase 3
33 Diuretics, Potassium Sparing Phase 3
34 Sodium Channel Blockers Phase 3
35 Calcium, Dietary Phase 3
36 Hormones Phase 3,Phase 2
37 Dopamine Uptake Inhibitors Phase 3,Phase 1,Phase 2
38 Neurotransmitter Uptake Inhibitors Phase 3,Phase 1,Phase 2
39 Central Nervous System Stimulants Phase 3
40 Dopamine Agents Phase 3,Phase 1,Phase 2
41 Epidiolex Phase 2, Phase 3
42
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
43
Tamoxifen Approved Phase 2 10540-29-1 2733526
44
Nicotine Approved Phase 1, Phase 2 54-11-5 89594 942
45
Bupropion Approved Phase 1, Phase 2 34841-39-9, 34911-55-2 444
46
Riluzole Approved, Investigational Phase 2 1744-22-5 5070
47 Antineoplastic Agents, Hormonal Phase 2
48 Hormone Antagonists Phase 2
49 Selective Estrogen Receptor Modulators Phase 2
50 Estrogen Antagonists Phase 2

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Efficacy and Safety of Flexible Dose of Quetiapine Fumarate (Seroquel) Switching From Other Drugs in the Treatment of Acute Manic Patients With Bipolar Disorder Unknown status NCT00837343 Phase 4 quetiapine fumarate tablet (Seroquel)
2 Transcranial Magnetic Stimulation in Bipolar Depression Completed NCT00186758 Phase 4
3 Melatonin Versus Placebo for Benzodiazepine Discontinuation in Patients With Schizophrenia Completed NCT01431092 Phase 4 Placebo;Melatonin
4 Comparison of Propofol Target-Controlled Infusion Anesthesia and Bolus Injection in Electroconvulsive Therapy Completed NCT03863925 Phase 4
5 Clinical Utility of Pharmacogenomics of Psychotropic Medications Not yet recruiting NCT03907124 Phase 4 Genetically-guided treatment with FDA-approved psychotropic drugs;Treatment as usual (TAU)
6 Comparison of Ketamine Combine Propofol vs Propofol Anesthesia in Schizophrenia Electroconvulsive Therapy Not yet recruiting NCT03829124 Phase 4 Propofol;Ketamine
7 Safety Study of Depakote Versus Lithium in African Americans With Bipolar Disorder Withdrawn NCT01075126 Phase 4 Depakote;Lithium
8 Prophylactic Effect of Lamotrigine Compared With Lithium in Bipolar Disorder Completed NCT00226135 Phase 3 lithium or lamotrigine
9 Methylphenidate for the Treatment of Acute Mania Completed NCT01541605 Phase 3 methylphenidate;Placebo
10 Cannabidiol as an Adjunctive Treatment for Bipolar Depression Recruiting NCT03310593 Phase 2, Phase 3 Cannabidiol;Placebo
11 rTMS in the Treatment of Bipolar Depression Unknown status NCT00436020 Phase 2
12 Anti-Estrogens - A Potential Treatment for Bipolar Affective Disorder in Women? Completed NCT00206544 Phase 2 Tamoxifen;Progesterone
13 A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Affective Disorder Completed NCT00593099 Phase 1, Phase 2 Bupropion;Placebo
14 Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar Disorder Terminated NCT00805493 Phase 2 Riluzole
15 Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder Withdrawn NCT00327756 Phase 2 Coenzyme Q10
16 Myths About Bipolar Affective Disorder: The Role of Structured Group Psychoeducation Therapy Unknown status NCT00474357 Not Applicable
17 Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder (PGBD) Unknown status NCT01272531 Mood stabilizer treatment
18 Psychiatric Disorders and Electrophysiological Markers Unknown status NCT02329119 Not Applicable
19 A Study of the Association Between Tobacco Smoking and Bipolar Affective Disorder Completed NCT00741299
20 Exercise for Depression Completed NCT02874833 Not Applicable
21 Bipolar Research Study Using MR Imaging Completed NCT02083978
22 Specialized Clozapine Clinic for Bipolar and Schizoaffective Disorder Completed NCT00683709
23 Bipolar Intervention Study: Cognitive Interpersonal Therapy Completed NCT01315028 Not Applicable
24 Genetic Aspects of Neurologic and Psychiatric Disorders Completed NCT00001544
25 Early Integrated Intervention in Severe Affective Disorders Completed NCT00253071 Not Applicable
26 The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels Completed NCT01385709
27 Blister Packaging Medication to Increase Treatment Adherence and Clinical Response Completed NCT01118208 Not Applicable
28 Home-based Transcranial Direct Current Stimulation in Fibromyalgia Patients Completed NCT02652988 Not Applicable
29 Transcranial Direct Current Stimulation Apparatus for Domiciliary Use Completed NCT02408237 Not Applicable
30 The Potential Efficacy of the Chinese Health Improvement Profile- A Pilot Clustered Randomised Controlled Trial Completed NCT02453217 Not Applicable
31 European Comparative Effectiveness Research on Internet-based Depression Treatment Completed NCT02542891 Not Applicable
32 Study of the Psychological Development of Children of Parents With and Without Affective Disorders Completed NCT00001170
33 Neurophysiologic Correlates of Hypersomnia Completed NCT01719315
34 Study of Sensorimotor Compatibility Effects in Bipolar Affective Disorder. Recruiting NCT03249857 Not Applicable
35 Evaluation of an App for Smartphones for People With a Bipolar Affective Disorder Recruiting NCT03275714 Not Applicable
36 Electronic Communication Augmented Mental Health Care Recruiting NCT03925038 Not Applicable
37 Improving Work Outcome for People With Severe Mental Illness Active, not recruiting NCT01722344 Not Applicable
38 Somatic Comorbidities in Psychiatric Patients Active, not recruiting NCT02773108
39 A Study of Aerobic Exercise for Patients With Bipolar Disorder Not yet recruiting NCT03353337 Not Applicable
40 Cannabinoids in Bipolar Affective Disorder Withdrawn NCT00397605 Not Applicable Synthetic cannabinoids (1:1 ratio of THC % CBD)

Search NIH Clinical Center for Major Affective Disorder 4

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Major Affective Disorder 4

Anatomical Context for Major Affective Disorder 4

MalaCards organs/tissues related to Major Affective Disorder 4:

42
Bone, Ovary, Pituitary, Thyroid

Publications for Major Affective Disorder 4

Articles related to Major Affective Disorder 4:

# Title Authors Year
1
Clinical Practice Guidelines for Bipolar Affective Disorder (BPAD) in Children and Adolescents. ( 30745704 )
2019
2
Impact of Pharmacist-Psychiatrist Collaborative Patient Education on Medication Adherence and Quality of Life (QOL) of Bipolar Affective Disorder (BPAD) Patients. ( 29066976 )
2017
3
An apparently dominant bipolar affective disorder (BPAD) locus on chromosome 20p11.2-q11.2 in a large Turkish pedigree. ( 11175298 )
2001

Variations for Major Affective Disorder 4

Expression for Major Affective Disorder 4

Search GEO for disease gene expression data for Major Affective Disorder 4.

Pathways for Major Affective Disorder 4

GO Terms for Major Affective Disorder 4

Sources for Major Affective Disorder 4

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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