BPAD
MCID: MJR004
MIFTS: 26

Major Affective Disorder 4 (BPAD)

Categories: Genetic diseases, Mental diseases

Aliases & Classifications for Major Affective Disorder 4

MalaCards integrated aliases for Major Affective Disorder 4:

Name: Major Affective Disorder 4 57 13 73
Bipolar Affective Disorder; Bpad 57
Bipolar Affective Disorder 57
Bipolar Disorder 73
Mafd4 57
Bpad 57

Classifications:



External Ids:

OMIM 57 611247
MedGen 42 C1970943

Summaries for Major Affective Disorder 4

MalaCards based summary : Major Affective Disorder 4, also known as bipolar affective disorder; bpad, is related to bipolar disorder and major affective disorder 1. An important gene associated with Major Affective Disorder 4 is MAFD4 (Major Affective Disorder 4). The drugs Lithium carbonate and Valproic Acid have been mentioned in the context of this disorder. Affiliated tissues include ovary and thyroid.

Description from OMIM: 611247

Related Diseases for Major Affective Disorder 4

Diseases in the Major Affective Disorder 1 family:

Major Affective Disorder 2 Major Affective Disorder 3
Major Affective Disorder 4 Major Affective Disorder 5
Major Affective Disorder 6 Major Affective Disorder 8
Major Affective Disorder 7 Major Affective Disorder 9

Diseases related to Major Affective Disorder 4 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 bipolar disorder 12.1
2 major affective disorder 1 12.0
3 major affective disorder 2 12.0
4 major affective disorder 5 12.0
5 major affective disorder 6 12.0
6 major affective disorder 3 11.5
7 perrault syndrome 1 11.1
8 schizophrenia 10.7
9 depression 10.4
10 major affective disorder 8 10.3
11 major affective disorder 7 10.3
12 major affective disorder 9 10.3
13 tardive dyskinesia 10.2
14 multiple sclerosis 10.2
15 major depressive disorder 10.2
16 obsessive-compulsive disorder 10.1
17 personality disorder 10.1
18 thalassemia 10.1
19 dementia 10.1
20 endogenous depression 10.1
21 substance abuse 10.1
22 frontotemporal dementia 10.0
23 alacrima, achalasia, and mental retardation syndrome 10.0
24 borderline personality disorder 10.0
25 hypothyroidism 10.0
26 mental depression 10.0
27 frontotemporal dementia with parkinsonism-17 10.0
28 head injury 10.0
29 autism 9.9
30 orthostatic intolerance 9.9
31 beta-thalassemia 9.9
32 hydrocephalus 9.9
33 conn's syndrome 9.9
34 schizoaffective disorder 9.9
35 periodontitis 9.9
36 cyclothymic disorder 9.9
37 learning disability 9.9
38 darier-white disease 9.8
39 jacobsen syndrome 9.8
40 klippel-trenaunay-weber syndrome 9.8
41 lithium transport 9.8
42 mccune-albright syndrome 9.8
43 pulmonary fibrosis, idiopathic 9.8
44 schizophrenia 1 9.8
45 hydrocephalus, normal-pressure 9.8
46 schizencephaly 9.8
47 cognitive function 1, social 9.8
48 aging 9.8
49 schizophrenia 2 9.8
50 anxiety 9.8

Graphical network of the top 20 diseases related to Major Affective Disorder 4:



Diseases related to Major Affective Disorder 4

Symptoms & Phenotypes for Major Affective Disorder 4

Clinical features from OMIM:

611247

Drugs & Therapeutics for Major Affective Disorder 4

Drugs for Major Affective Disorder 4 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lithium carbonate Approved Phase 4,Phase 3 554-13-2
2
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
3
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
4 Tranquilizing Agents Phase 4,Phase 3
5 Psychotropic Drugs Phase 4,Phase 3,Phase 1,Phase 2
6 Antipsychotic Agents Phase 4
7 Central Nervous System Depressants Phase 4,Phase 3
8 Quetiapine Fumarate Phase 4 111974-72-2
9 Antimanic Agents Phase 4,Phase 3
10 GABA Agents Phase 4
11 Antidepressive Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
12 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2
13 Anticonvulsants Phase 4,Phase 3,Phase 2
14 Protective Agents Phase 4,Phase 2
15 Antioxidants Phase 4
16
Lamotrigine Approved, Investigational Phase 3 84057-84-1 3878
17
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
18
Dopamine Approved Phase 3,Phase 1,Phase 2 51-61-6, 62-31-7 681
19 Diuretics, Potassium Sparing Phase 3
20 Excitatory Amino Acid Antagonists Phase 3,Phase 2
21 Sodium Channel Blockers Phase 3
22 Calcium, Dietary Phase 3
23 Excitatory Amino Acids Phase 3,Phase 2
24 calcium channel blockers Phase 3
25 Neurotransmitter Uptake Inhibitors Phase 3,Phase 1,Phase 2
26 Dopamine Uptake Inhibitors Phase 3,Phase 1,Phase 2
27 Central Nervous System Stimulants Phase 3
28 Dopamine Agents Phase 3,Phase 1,Phase 2
29
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
30
Tamoxifen Approved Phase 2 10540-29-1 2733526
31
Nicotine Approved Phase 1, Phase 2 54-11-5 942 89594
32
Bupropion Approved Phase 1, Phase 2 34841-39-9, 34911-55-2 444
33
Riluzole Approved, Investigational Phase 2 1744-22-5 5070
34
Coenzyme Q10 Approved, Investigational, Nutraceutical Phase 2 303-98-0 5281915
35 Progestins Phase 2
36 Hormones Phase 2
37 Estrogens Phase 2
38 Estrogen Antagonists Phase 2
39 Selective Estrogen Receptor Modulators Phase 2
40 Estrogen Receptor Modulators Phase 2
41 Bone Density Conservation Agents Phase 2
42 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
43 Antineoplastic Agents, Hormonal Phase 2
44 Hormone Antagonists Phase 2
45 Estrogen Receptor Antagonists Phase 2
46 Antidepressive Agents, Second-Generation Phase 1, Phase 2
47 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2
48 Cytochrome P-450 CYP2D6 Inhibitors Phase 1, Phase 2
49 Trace Elements Phase 2
50 Micronutrients Phase 2

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Efficacy and Safety of Flexible Dose of Quetiapine Fumarate (Seroquel) Switching From Other Drugs in the Treatment of Acute Manic Patients With Bipolar Disorder Unknown status NCT00837343 Phase 4 quetiapine fumarate tablet (Seroquel)
2 Transcranial Magnetic Stimulation in Bipolar Depression Completed NCT00186758 Phase 4
3 Melatonin Versus Placebo for Benzodiazepine Discontinuation in Patients With Schizophrenia Completed NCT01431092 Phase 4 Placebo;Melatonin
4 Safety Study of Depakote Versus Lithium in African Americans With Bipolar Disorder Withdrawn NCT01075126 Phase 4 Depakote;Lithium
5 Prophylactic Effect of Lamotrigine Compared With Lithium in Bipolar Disorder Completed NCT00226135 Phase 3 lithium or lamotrigine
6 Methylphenidate for the Treatment of Acute Mania Completed NCT01541605 Phase 3 methylphenidate;Placebo
7 Cannabidiol as an Adjunctive Treatment for Bipolar Depression Recruiting NCT03310593 Phase 2, Phase 3 Cannabidiol;Placebo
8 rTMS in the Treatment of Bipolar Depression Unknown status NCT00436020 Phase 2
9 Anti-Estrogens - A Potential Treatment for Bipolar Affective Disorder in Women? Completed NCT00206544 Phase 2 Tamoxifen;Progesterone
10 A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Affective Disorder Completed NCT00593099 Phase 1, Phase 2 Bupropion;Placebo
11 Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder Withdrawn NCT00327756 Phase 2 Coenzyme Q10
12 Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar Disorder Terminated NCT00805493 Phase 2 Riluzole
13 Myths About Bipolar Affective Disorder: The Role of Structured Group Psychoeducation Therapy Unknown status NCT00474357 Not Applicable
14 Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder (PGBD) Unknown status NCT01272531 Mood stabilizer treatment
15 Study of Sensorimotor Compatibility Effects in Bipolar Affective Disorder. Recruiting NCT03249857 Not Applicable
16 Evaluation of an App for Smartphones for People With a Bipolar Affective Disorder Recruiting NCT03275714 Not Applicable
17 A Study of the Association Between Tobacco Smoking and Bipolar Affective Disorder Completed NCT00741299
18 Cannabinoids in Bipolar Affective Disorder Withdrawn NCT00397605 Not Applicable Synthetic cannabinoids (1:1 ratio of THC % CBD)
19 Exercise for Depression Completed NCT02874833 Not Applicable
20 Bipolar Research Study Using MR Imaging Completed NCT02083978
21 A Study of Aerobic Exercise for Patients With Bipolar Disorder Not yet recruiting NCT03353337 Not Applicable
22 Specialized Clozapine Clinic for Bipolar and Schizoaffective Disorder Completed NCT00683709
23 Psychiatric Disorders and Electrophysiological Markers Not yet recruiting NCT02329119 Not Applicable
24 Bipolar Intervention Study: Cognitive Interpersonal Therapy Completed NCT01315028 Not Applicable
25 Genetic Aspects of Neurologic and Psychiatric Disorders Completed NCT00001544
26 Improving Work Outcome for People With Severe Mental Illness Active, not recruiting NCT01722344 Not Applicable
27 Somatic Comorbidities in Psychiatric Patients Active, not recruiting NCT02773108
28 Early Integrated Intervention in Severe Affective Disorders Completed NCT00253071 Not Applicable
29 The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels Completed NCT01385709
30 Blister Packaging Medication to Increase Treatment Adherence and Clinical Response Completed NCT01118208 Not Applicable
31 Home-based Transcranial Direct Current Stimulation in Fibromyalgia Patients Completed NCT02652988 Not Applicable
32 Transcranial Direct Current Stimulation Apparatus for Domiciliary Use Completed NCT02408237 Not Applicable
33 The Potential Efficacy of the Chinese Health Improvement Profile- A Pilot Clustered Randomised Controlled Trial Active, not recruiting NCT02453217 Not Applicable
34 European Comparative Effectiveness Research on Internet-based Depression Treatment Completed NCT02542891 Not Applicable
35 Study of the Psychological Development of Children of Parents With and Without Affective Disorders Completed NCT00001170
36 Neurophysiologic Correlates of Hypersomnia Completed NCT01719315

Search NIH Clinical Center for Major Affective Disorder 4

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Major Affective Disorder 4

Anatomical Context for Major Affective Disorder 4

MalaCards organs/tissues related to Major Affective Disorder 4:

41
Ovary, Thyroid

Publications for Major Affective Disorder 4

Articles related to Major Affective Disorder 4:

# Title Authors Year
1
Impact of Pharmacist-Psychiatrist Collaborative Patient Education on Medication Adherence and Quality of Life (QOL) of Bipolar Affective Disorder (BPAD) Patients. ( 29066976 )
2017
2
An apparently dominant bipolar affective disorder (BPAD) locus on chromosome 20p11.2-q11.2 in a large Turkish pedigree. ( 11175298 )
2001

Variations for Major Affective Disorder 4

Expression for Major Affective Disorder 4

Search GEO for disease gene expression data for Major Affective Disorder 4.

Pathways for Major Affective Disorder 4

GO Terms for Major Affective Disorder 4

Sources for Major Affective Disorder 4

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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