MAFD7
MCID: MJR023
MIFTS: 39

Major Affective Disorder 7 (MAFD7)

Categories: Genetic diseases, Mental diseases

Aliases & Classifications for Major Affective Disorder 7

MalaCards integrated aliases for Major Affective Disorder 7:

Name: Major Affective Disorder 7 57 75 29 40 73
Major Affective Disorder-7, Susceptibility to 57 13
Bipolar Affective Disorder 57 75
Mafd7 57 75
Major Affective Disorder 7, Susceptibility to 6
Major Affective Disorder 1 73
Manic-Depressive Psychosis 75
Major Affective Disorder 2 73
Major Affective Disorder-7 57
Manic Depressive Illness 75
Bipolar Disorder 73

Classifications:



External Ids:

OMIM 57 612371
MedGen 42 C2700438
MeSH 44 D001714

Summaries for Major Affective Disorder 7

UniProtKB/Swiss-Prot : 75 Major affective disorder 7: A major psychiatric disorder that is characterized by severe mood swings, with fluctuation between two abnormal mood states (manic or major depressive episode). Mania is accompanied by symptoms of euphoria, irritability, or excitation, whereas depression is associated with low mood and decreased motivation and energy.

MalaCards based summary : Major Affective Disorder 7, also known as major affective disorder-7, susceptibility to, is related to major affective disorder 8 and major affective disorder 9. An important gene associated with Major Affective Disorder 7 is XBP1 (X-Box Binding Protein 1). The drugs Lithium carbonate and Valproic Acid have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and cortex.

Description from OMIM: 612371

Related Diseases for Major Affective Disorder 7

Diseases in the Major Affective Disorder 1 family:

Major Affective Disorder 2 Major Affective Disorder 3
Major Affective Disorder 4 Major Affective Disorder 5
Major Affective Disorder 6 Major Affective Disorder 8
Major Affective Disorder 7 Major Affective Disorder 9

Diseases related to Major Affective Disorder 7 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 major affective disorder 8 11.9
2 major affective disorder 9 11.9
3 major affective disorder 4 11.8
4 major affective disorder 5 11.8
5 major affective disorder 6 11.8
6 major affective disorder 1 11.8
7 major affective disorder 2 11.7
8 mental retardation, x-linked, syndromic 13 11.6
9 bipolar disorder 11.6
10 major affective disorder 3 11.5
11 depression 10.4
12 color blindness 10.2
13 color vision deficiency 10.2
14 tardive dyskinesia 10.2
15 major depressive disorder 10.2
16 obsessive-compulsive disorder 10.1
17 personality disorder 10.1
18 paranoid schizophrenia 10.1
19 multiple sclerosis 10.1
20 schizophrenia 10.1
21 syphilis 10.1
22 neurotic disorder 10.1
23 tertiary syphilis 10.1
24 thalassemia 10.1
25 dementia 10.1
26 endogenous depression 10.1
27 substance abuse 10.1
28 frontotemporal dementia 10.0
29 alacrima, achalasia, and mental retardation syndrome 10.0
30 borderline personality disorder 10.0
31 hypothyroidism 10.0
32 mental depression 10.0
33 frontotemporal dementia with parkinsonism-17 10.0
34 head injury 10.0
35 graves disease 1 10.0
36 colorblindness, partial, deutan series 10.0
37 aceruloplasminemia 10.0
38 antisocial personality disorder 10.0
39 aseptic meningitis 10.0
40 meningitis 10.0
41 hypersomnia 10.0
42 autism 9.9
43 orthostatic intolerance 9.9
44 beta-thalassemia 9.9
45 hydrocephalus 9.9
46 conn's syndrome 9.9
47 schizoaffective disorder 9.9
48 periodontitis 9.9
49 cyclothymic disorder 9.9
50 learning disability 9.9

Graphical network of the top 20 diseases related to Major Affective Disorder 7:



Diseases related to Major Affective Disorder 7

Symptoms & Phenotypes for Major Affective Disorder 7

Clinical features from OMIM:

612371

Drugs & Therapeutics for Major Affective Disorder 7

Drugs for Major Affective Disorder 7 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lithium carbonate Approved Phase 4,Phase 3 554-13-2
2
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
3
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
4 Tranquilizing Agents Phase 4,Phase 3
5 Psychotropic Drugs Phase 4,Phase 3,Phase 1,Phase 2
6 Antipsychotic Agents Phase 4
7 Central Nervous System Depressants Phase 4,Phase 3
8 Quetiapine Fumarate Phase 4 111974-72-2
9 Antimanic Agents Phase 4,Phase 3
10 GABA Agents Phase 4
11 Antidepressive Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
12 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2
13 Anticonvulsants Phase 4,Phase 3,Phase 2
14 Protective Agents Phase 4,Phase 2
15 Antioxidants Phase 4
16
Lamotrigine Approved, Investigational Phase 3 84057-84-1 3878
17
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
18
Dopamine Approved Phase 3,Phase 1,Phase 2 51-61-6, 62-31-7 681
19 Diuretics, Potassium Sparing Phase 3
20 Excitatory Amino Acid Antagonists Phase 3,Phase 2
21 Sodium Channel Blockers Phase 3
22 Calcium, Dietary Phase 3
23 Excitatory Amino Acids Phase 3,Phase 2
24 calcium channel blockers Phase 3
25 Neurotransmitter Uptake Inhibitors Phase 3,Phase 1,Phase 2
26 Dopamine Uptake Inhibitors Phase 3,Phase 1,Phase 2
27 Central Nervous System Stimulants Phase 3
28 Dopamine Agents Phase 3,Phase 1,Phase 2
29
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
30
Tamoxifen Approved Phase 2 10540-29-1 2733526
31
Nicotine Approved Phase 1, Phase 2 54-11-5 942 89594
32
Bupropion Approved Phase 1, Phase 2 34841-39-9, 34911-55-2 444
33
Riluzole Approved, Investigational Phase 2 1744-22-5 5070
34
Coenzyme Q10 Approved, Investigational, Nutraceutical Phase 2 303-98-0 5281915
35 Progestins Phase 2
36 Hormones Phase 2
37 Estrogens Phase 2
38 Estrogen Antagonists Phase 2
39 Selective Estrogen Receptor Modulators Phase 2
40 Estrogen Receptor Modulators Phase 2
41 Bone Density Conservation Agents Phase 2
42 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
43 Antineoplastic Agents, Hormonal Phase 2
44 Hormone Antagonists Phase 2
45 Estrogen Receptor Antagonists Phase 2
46 Antidepressive Agents, Second-Generation Phase 1, Phase 2
47 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2
48 Cytochrome P-450 CYP2D6 Inhibitors Phase 1, Phase 2
49 Trace Elements Phase 2
50 Micronutrients Phase 2

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Efficacy and Safety of Flexible Dose of Quetiapine Fumarate (Seroquel) Switching From Other Drugs in the Treatment of Acute Manic Patients With Bipolar Disorder Unknown status NCT00837343 Phase 4 quetiapine fumarate tablet (Seroquel)
2 Transcranial Magnetic Stimulation in Bipolar Depression Completed NCT00186758 Phase 4
3 Melatonin Versus Placebo for Benzodiazepine Discontinuation in Patients With Schizophrenia Completed NCT01431092 Phase 4 Placebo;Melatonin
4 Safety Study of Depakote Versus Lithium in African Americans With Bipolar Disorder Withdrawn NCT01075126 Phase 4 Depakote;Lithium
5 Prophylactic Effect of Lamotrigine Compared With Lithium in Bipolar Disorder Completed NCT00226135 Phase 3 lithium or lamotrigine
6 Methylphenidate for the Treatment of Acute Mania Completed NCT01541605 Phase 3 methylphenidate;Placebo
7 Cannabidiol as an Adjunctive Treatment for Bipolar Depression Recruiting NCT03310593 Phase 2, Phase 3 Cannabidiol;Placebo
8 rTMS in the Treatment of Bipolar Depression Unknown status NCT00436020 Phase 2
9 Anti-Estrogens - A Potential Treatment for Bipolar Affective Disorder in Women? Completed NCT00206544 Phase 2 Tamoxifen;Progesterone
10 A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Affective Disorder Completed NCT00593099 Phase 1, Phase 2 Bupropion;Placebo
11 Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder Withdrawn NCT00327756 Phase 2 Coenzyme Q10
12 Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar Disorder Terminated NCT00805493 Phase 2 Riluzole
13 Myths About Bipolar Affective Disorder: The Role of Structured Group Psychoeducation Therapy Unknown status NCT00474357 Not Applicable
14 Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder (PGBD) Unknown status NCT01272531 Mood stabilizer treatment
15 Study of Sensorimotor Compatibility Effects in Bipolar Affective Disorder. Recruiting NCT03249857 Not Applicable
16 Evaluation of an App for Smartphones for People With a Bipolar Affective Disorder Recruiting NCT03275714 Not Applicable
17 A Study of the Association Between Tobacco Smoking and Bipolar Affective Disorder Completed NCT00741299
18 Cannabinoids in Bipolar Affective Disorder Withdrawn NCT00397605 Not Applicable Synthetic cannabinoids (1:1 ratio of THC % CBD)
19 Exercise for Depression Completed NCT02874833 Not Applicable
20 Bipolar Research Study Using MR Imaging Completed NCT02083978
21 A Study of Aerobic Exercise for Patients With Bipolar Disorder Not yet recruiting NCT03353337 Not Applicable
22 Specialized Clozapine Clinic for Bipolar and Schizoaffective Disorder Completed NCT00683709
23 Psychiatric Disorders and Electrophysiological Markers Not yet recruiting NCT02329119 Not Applicable
24 Bipolar Intervention Study: Cognitive Interpersonal Therapy Completed NCT01315028 Not Applicable
25 Genetic Aspects of Neurologic and Psychiatric Disorders Completed NCT00001544
26 Improving Work Outcome for People With Severe Mental Illness Active, not recruiting NCT01722344 Not Applicable
27 Somatic Comorbidities in Psychiatric Patients Active, not recruiting NCT02773108
28 Early Integrated Intervention in Severe Affective Disorders Completed NCT00253071 Not Applicable
29 The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels Completed NCT01385709
30 Blister Packaging Medication to Increase Treatment Adherence and Clinical Response Completed NCT01118208 Not Applicable
31 Home-based Transcranial Direct Current Stimulation in Fibromyalgia Patients Completed NCT02652988 Not Applicable
32 Transcranial Direct Current Stimulation Apparatus for Domiciliary Use Completed NCT02408237 Not Applicable
33 The Potential Efficacy of the Chinese Health Improvement Profile- A Pilot Clustered Randomised Controlled Trial Active, not recruiting NCT02453217 Not Applicable
34 European Comparative Effectiveness Research on Internet-based Depression Treatment Completed NCT02542891 Not Applicable
35 Study of the Psychological Development of Children of Parents With and Without Affective Disorders Completed NCT00001170
36 Neurophysiologic Correlates of Hypersomnia Completed NCT01719315

Search NIH Clinical Center for Major Affective Disorder 7

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Major Affective Disorder 7

Genetic tests related to Major Affective Disorder 7:

# Genetic test Affiliating Genes
1 Major Affective Disorder 7 29 XBP1

Anatomical Context for Major Affective Disorder 7

MalaCards organs/tissues related to Major Affective Disorder 7:

41
Brain, Thyroid, Cortex, Bone, Testes, Amygdala, Ovary

Publications for Major Affective Disorder 7

Articles related to Major Affective Disorder 7:

(show top 50) (show all 779)
# Title Authors Year
1
Polycystic Ovary Syndrome in Bipolar Affective Disorder: A Hospital-based Study. ( 29962567 )
2018
2
Polydipsia as a Precursor of Manic Episode in Bipolar Affective Disorder Patients with Alcohol Use Disorder. ( 29397674 )
2018
3
Bipolar affective disorder and borderline personality disorder: Differentiation based on the history of early life stress and psychoneuroendocrine measures. ( 29702176 )
2018
4
Lithium-induced Symptomatic Hypercalcemia and Hyperparathyroidism in a Patient with Bipolar Affective Disorder: A Case Report and Review of Literature. ( 30093752 )
2018
5
Novel functional variants at the GWAS-implicated loci might confer risk to major depressive disorder, bipolar affective disorder and schizophrenia. ( 29745862 )
2018
6
Corrigendum to "Analysis of association between common SNPs in ErbB4 and bipolar affective disorder, major depressive disorder and schizophrenia in the Han Chinese population" [Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 36 (2012) 17-21]. ( 28803680 )
2018
7
Lithium-induced Thyroiditis in a Patient Having Bipolar Affective Disorder - A Rare Case Report. ( 30533956 )
2018
8
Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study. ( 29121268 )
2018
9
Effectiveness of Mindfulness-based Cognitive Therapy in Patients with Bipolar Affective Disorder: A Case Series. ( 29343935 )
2018
10
Assessing Caregiver Burden in Caregivers of Patients with Schizophrenia and Bipolar Affective Disorder in Kathmandu Medical College. ( 29353899 )
2018
11
Bipolar Affective Disorder in a Patient of Profound Deafness. ( 29482712 )
2018
12
Managing Bipolar Affective Disorder in a Tribal District of Odisha. ( 29875526 )
2018
13
Neuropsychological Functioning in Euthymic Phase of Bipolar Affective Disorder. ( 29875527 )
2018
14
A gene co-expression module implicating the mitochondrial electron transport chain is associated with long-term response to lithium treatment in bipolar affective disorder. ( 30185780 )
2018
15
A Rare Presentation of a Case of Obsessive-compulsive Disorder Comorbid with Bipolar Affective Disorder. ( 29284814 )
2017
16
Predictors of rehospitalization in a naturalistic cohort of patients with bipolar affective disorder. ( 28207568 )
2017
17
The temperament and character traits in patients with major depressive disorder and bipolar affective disorder with and without suicide attempt. ( 28636575 )
2017
18
Bipolar affective disorder and childhood adversity: possible genetic links? ( 28465388 )
2017
19
Schizophrenia and Bipolar Affective Disorder: a Dimensional Approach. ( 28636571 )
2017
20
High-dose levothyroxine for the management of bipolar affective disorder: two case reports. ( 28904805 )
2017
21
A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia. ( 29049482 )
2017
22
Impact of Pharmacist-Psychiatrist Collaborative Patient Education on Medication Adherence and Quality of Life (QOL) of Bipolar Affective Disorder (BPAD) Patients. ( 29066976 )
2017
23
Prevalence and Sociodemographic Profile of Lithium-induced Cutaneous Side Effects in Bipolar Affective Disorder Patients: A 1-year Prospective Observational Study in South India. ( 29200562 )
2017
24
Positive Aspects of Caregiving and Its Correlates among Caregivers of Bipolar Affective Disorder. ( 29259143 )
2017
25
Bipolar affective disorder and its impact on various aspects of marital relationship. ( 30089956 )
2017
26
Outcomes of Renal Transplantation in Patients With Bipolar Affective Disorder and Schizophrenia: A National Retrospective Cohort Study. ( 27887740 )
2017
27
Identification of rare nonsynonymous variants in SYNE1/CPG2 in bipolar affective disorder. ( 28178086 )
2017
28
Adverse events associated with mood stabiliser treatment should be continuously monitored in patients diagnosed with bipolar affective disorder. ( 28254753 )
2017
29
The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment. ( 28289283 )
2017
30
DGKH genetic risk variant influences gene expression in bipolar affective disorder. ( 27016658 )
2016
31
Cardiac (123)I-meta-iodo-benzyl-guanine in a patient with bipolar affective disorder, musical hallucinations and Parkinsonism. ( 26346109 )
2016
32
Abnormal early brain responses during visual search are evident in schizophrenia but not bipolar affective disorder. ( 26603466 )
2016
33
Can Psychological, Social and Demographical Factors Predict Clinical Characteristics Symptomatology of Bipolar Affective Disorder and Schizophrenia? ( 26646576 )
2016
34
Disability and Quality of Life of Subjects with Bipolar Affective Disorder in Remission. ( 27570346 )
2016
35
Are SSRIs responsible for precipitating suicidal ideation in teenagers with 'subsyndromal' bipolar affective disorder who have been misdiagnosed with unipolar depression? ( 27663811 )
2016
36
Hospital treatment, mortality and healthcare costs in relation to socioeconomic status among people with bipolar affective disorder. ( 27703748 )
2016
37
Relationship between childhood adversity and bipolar affective disorder: systematic review and meta-analysis. ( 27758835 )
2016
38
CASE-REPORT Case study of a patient presenting both type II bipolar affective disorder and Klinefelter syndrome. ( 27813593 )
2016
39
Distressing cutaneous lesion among bipolar affective disorder patients on lithium therapy: A retrospective cross-sectional study. ( 28196994 )
2016
40
Selective impairment of global motion integration, but not global form detection, in schizophrenia and bipolar affective disorder. ( 28740802 )
2016
41
Comparative neuropsychiatry: white matter abnormalities in children and adolescents with schizophrenia, bipolar affective disorder, and obsessive-compulsive disorder. ( 25498242 )
2015
42
Frontotemporal dementia mimicking bipolar affective disorder, normal pressure hydrocephalus and KlA1ver-Bucy syndrome. ( 26482719 )
2015
43
Influence of DGKH variants on amygdala volume in patients with bipolar affective disorder and schizophrenia. ( 24958494 )
2015
44
Disturbed cortico-amygdalar functional connectivity as pathophysiological correlate of working memory deficits in bipolar affective disorder. ( 25119145 )
2015
45
Adverse childhood events and psychosis in bipolar affective disorder. ( 25614532 )
2015
46
Bipolar affective disorder in Huntington's disease: A neuropsychiatric perspective. ( 25657476 )
2015
47
Available screening tools for adults suffering from bipolar affective disorder in primary care: An integrative literature review. ( 25691013 )
2015
48
Proteomic pathway analysis of the hippocampus in schizophrenia and bipolar affective disorder implicates 14-3-3 signaling, aryl hydrocarbon receptor signaling, and glucose metabolism: potential roles in GABAergic interneuron pathology. ( 25728835 )
2015
49
A systematic review and meta-analysis of premature mortality in bipolar affective disorder. ( 25735195 )
2015
50
Managing psychosis in a renal transplant recipient with bipolar affective disorder and allograft rejection. ( 25807849 )
2015

Variations for Major Affective Disorder 7

ClinVar genetic disease variations for Major Affective Disorder 7:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 XBP1 XBP1, -116C-G single nucleotide variant risk factor

Expression for Major Affective Disorder 7

Search GEO for disease gene expression data for Major Affective Disorder 7.

Pathways for Major Affective Disorder 7

GO Terms for Major Affective Disorder 7

Sources for Major Affective Disorder 7

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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