MAFD7
MCID: MJR023
MIFTS: 33

Major Affective Disorder 7 (MAFD7)

Categories: Genetic diseases, Mental diseases

Aliases & Classifications for Major Affective Disorder 7

MalaCards integrated aliases for Major Affective Disorder 7:

Name: Major Affective Disorder 7 56 73 29 6 39 71
Major Affective Disorder-7, Susceptibility to 56 13
Bipolar Affective Disorder 56 73
Mafd7 56 73
Major Affective Disorder 7, Susceptibility to 6
Major Affective Disorder 1 71
Manic-Depressive Psychosis 73
Major Affective Disorder 2 71
Major Affective Disorder-7 56
Manic Depressive Illness 73
Bipolar Disorder 71

Classifications:



External Ids:

OMIM 56 612371
MeSH 43 D001714
MedGen 41 C2700438
UMLS 71 C0005586 C1839839 C1852197 more

Summaries for Major Affective Disorder 7

UniProtKB/Swiss-Prot : 73 Major affective disorder 7: A major psychiatric disorder that is characterized by severe mood swings, with fluctuation between two abnormal mood states (manic or major depressive episode). Mania is accompanied by symptoms of euphoria, irritability, or excitation, whereas depression is associated with low mood and decreased motivation and energy.

MalaCards based summary : Major Affective Disorder 7, also known as major affective disorder-7, susceptibility to, is related to major affective disorder 1 and major affective disorder 2. An important gene associated with Major Affective Disorder 7 is XBP1 (X-Box Binding Protein 1). The drugs Paroxetine and Eleuthero have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye.

More information from OMIM: 612371

Related Diseases for Major Affective Disorder 7

Diseases in the Major Affective Disorder 1 family:

Major Affective Disorder 2 Major Affective Disorder 3
Major Affective Disorder 4 Major Affective Disorder 5
Major Affective Disorder 6 Major Affective Disorder 8
Major Affective Disorder 7 Major Affective Disorder 9

Diseases related to Major Affective Disorder 7 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 219)
# Related Disease Score Top Affiliating Genes
1 major affective disorder 1 12.3
2 major affective disorder 2 12.2
3 bipolar disorder 12.0
4 major affective disorder 5 12.0
5 major affective disorder 6 12.0
6 mental retardation, x-linked, syndromic 13 11.7
7 major affective disorder 3 11.7
8 major affective disorder 4 11.7
9 schizophrenia 10.6
10 depression 10.5
11 bipolar i disorder 10.4
12 major affective disorder 8 10.4
13 major affective disorder 9 10.4
14 mental depression 10.4
15 color blindness 10.4
16 major depressive disorder 10.4
17 color vision deficiency 10.3
18 neurotic disorder 10.3
19 personality disorder 10.3
20 schizoaffective disorder 10.3
21 alcohol dependence 10.3
22 tardive dyskinesia 10.3
23 obsessive-compulsive disorder 10.3
24 yemenite deaf-blind hypopigmentation syndrome 10.3
25 depersonalization disorder 10.3
26 psychotic disorder 10.3
27 melancholia 10.3
28 mood disorder 10.3
29 paranoid schizophrenia 10.2
30 substance abuse 10.2
31 hypothyroidism 10.2
32 attention deficit-hyperactivity disorder 10.2
33 cyclothymic disorder 10.2
34 ataxia and polyneuropathy, adult-onset 10.2
35 huntington disease 10.1
36 mental health wellness 1 10.1
37 mental health wellness 2 10.1
38 borderline personality disorder 10.1
39 severe combined immunodeficiency 10.1
40 pfeiffer syndrome 10.1
41 multiple sclerosis 10.1
42 hand skill, relative 10.1
43 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
44 asthma 10.1
45 anxiety 10.1
46 aphasia 10.1
47 hypogonadotropic hypogonadism 10.1
48 sexual sadism 10.1
49 dysthymic disorder 10.1
50 obstructive jaundice 10.1

Graphical network of the top 20 diseases related to Major Affective Disorder 7:



Diseases related to Major Affective Disorder 7

Symptoms & Phenotypes for Major Affective Disorder 7

Clinical features from OMIM:

612371

Drugs & Therapeutics for Major Affective Disorder 7

Drugs for Major Affective Disorder 7 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 425)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
2
Eleuthero Approved, Experimental Phase 4
3
Reboxetine Approved, Experimental Phase 4 98769-81-4, 71620-89-8 123628 65856
4
Topiramate Approved Phase 4 97240-79-4 5284627
5
Tranylcypromine Approved, Investigational Phase 4 155-09-9 441233
6
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
7
Oxcarbazepine Approved Phase 4 28721-07-5 34312
8
Galantamine Approved Phase 4 357-70-0 9651
9
Ropinirole Approved, Investigational Phase 4 91374-20-8, 91374-21-9 497540 5095
10
Memantine Approved, Investigational Phase 4 19982-08-2 4054
11
Sertraline Approved Phase 4 79617-96-2 68617
12
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
13
Cocaine Approved, Illicit Phase 4 50-36-2 446220 5760
14
Acamprosate Approved, Investigational Phase 4 77337-76-9 71158
15
Levetiracetam Approved Phase 4 102767-28-2 441341
16
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
17
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
18
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
19
Cycloserine Approved Phase 4 68-41-7 401 6234
20
Norepinephrine Approved Phase 4 51-41-2 439260
21
Nortriptyline Approved Phase 4 72-69-5 4543
22
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
23
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
24
Histamine Approved, Investigational Phase 4 51-45-6 774
25
Mirtazapine Approved Phase 4 85650-52-8, 61337-67-5 4205
26
Iloperidone Approved Phase 4 133454-47-4 71360
27
Brexpiprazole Approved, Investigational Phase 4 913611-97-9 11978813
28
Methohexital Approved Phase 4 151-83-7 9034
29
Dipyridamole Approved Phase 4 58-32-2 3108
30
Chlorpromazine Approved, Investigational, Vet_approved Phase 4 50-53-3 2726
31
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
32
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
33
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
34
Lorazepam Approved Phase 4 846-49-1 3958
35
Varenicline Approved, Investigational Phase 4 249296-44-4 5310966
36
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
37
Loxapine Approved Phase 4 1977-10-2 3964
38
Metformin Approved Phase 4 657-24-9 14219 4091
39
Dextroamphetamine Approved, Illicit Phase 4 51-64-9 5826
40
Amphetamine Approved, Illicit, Investigational Phase 4 300-62-9 5826 3007
41
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
42
Hydroxocobalamin Approved Phase 4 13422-51-0 15589840 11953898
43
Acetaminophen Approved Phase 4 103-90-2 1983
44
gamma-Aminobutyric acid Approved, Investigational Phase 4 56-12-2 119
45
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
46
Angiotensin II Approved, Investigational Phase 4 4474-91-3, 11128-99-7, 68521-88-0 172198
47
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
48
Racepinephrine Approved Phase 4 329-65-7 838
49
Ondansetron Approved Phase 4 99614-02-5 4595
50
Simvastatin Approved Phase 4 79902-63-9 54454

Interventional clinical trials:

(show top 50) (show all 1546)
# Name Status NCT ID Phase Drugs
1 An Open Label, Multicenter, Single Arm, 4-Week Study to Evaluate the Efficacy and Safety of Flexible Dose of Quetiapine Fumarate (Seroquel) Switching From Other Drugs in the Treatment of Acute Manic Patients With Bipolar Disorder Unknown status NCT00837343 Phase 4 quetiapine fumarate tablet (Seroquel)
2 Effects of N-Acetyl-Cysteine on Oxidative Stress Biomarkers in Bipolar Patients With and Without Tobacco Use Disorder Unknown status NCT02252341 Phase 4
3 Neurofunctional and Neurochemical Markers of Treatment Response in Bipolar Disorder Unknown status NCT00608075 Phase 4 lithium;Lithium
4 Exploring Alterations of Central Autonomic Modulation in Patients With Bipolar Depression Unknown status NCT01213121 Phase 4 Quetiapine
5 Assessing the Efficacy of Left Repetitive Transcranial Magnetic Stimulation (rTMS) as an Adjunctive Treatment to Mood Stabilizers for the Treatment of Bipolar Depression Unknown status NCT01583023 Phase 4 Bupropion
6 Assessment and Follow Up Study of Children and Adolescent With Bipolar Disorder Unknown status NCT01000402 Phase 4 Psychopharmacotherapy
7 A Placebo Controlled Trial of the Dopamine D-2 Receptor Agonist Ropinirole in Treatment of 60 Patients With Refractory Bipolar I and II Depression. Unknown status NCT00335205 Phase 4 ropinirole
8 Algorithm Guided Treatment Strategies for Bipolar Depression Unknown status NCT01938859 Phase 4 Lithium;Quetiapine;Shuganjieyu capsule
9 Clinical Psychopharmacology Division Institute of Mental Health, Peking University Unknown status NCT03148535 Phase 4 Lithium Carbonate;lithium carbonate combined with SSRI antidepressant treatment
10 A Randomized Open-label Active-controlled Study to Evaluate the Efficacy and Safety of Utapine Versus Seroquel in Patients With Bipolar Mania Unknown status NCT01043679 Phase 4 Utapine;Seroquel
11 Comparative Efficacy and Acceptability of Lithium, Valproate, Oxcarbazepine, Quetiapine, Olanzapine, and Ziprasidone in Bipolar I Disorder, Manic or Mixed Phase Unknown status NCT01893229 Phase 4 Lithium;Valproate;Oxcarbazepine;Quetiapine;Olanzapine;Ziprasidone
12 Open Label Prophylaxis Study of Lithium Plus Extended- Release Carbamazepine (Equetro®) Combination for Rapid Cycling Bipolar Disorder Unknown status NCT00325286 Phase 4 Lithium Plus Extended- Release Carbamazepine
13 Reduction of Cardiovascular Risk in Severe Mental Illness Prescribing and Using Better and More Appropriated Drugs Unknown status NCT01182012 Phase 4
14 An Exploratory Randomized Open Comparison of Oxtellar XR® vs Oxcarbazepine IR (Trileptal®) for the Treatment of Bipolar Depression Unknown status NCT03567681 Phase 4 Extended release oxcarbazepine vs Immediate release oxcarbazepine
15 Reversal of Antipsychotic-Induced Hyperprolactinemia, Weight Gain, Hyperglycemia and Dyslipidemia by Aripiprazole Add-on Therapy in the Treatment of Schizophrenia and Bipolar Disorder: An Open-Label Trial Unknown status NCT00541554 Phase 4 Abilify (aripiprazole)
16 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in PCOS Patients. Unknown status NCT01246310 Phase 4
17 Integrated Smoking Cessation Treatment for Smokers With Serious Mental Illness Unknown status NCT02845440 Phase 4
18 Phase 3 Reboxetine Treatment in Depressed Children and Adolescents an 8-Week, Open Study Unknown status NCT00426946 Phase 4 Reboxetine
19 The Effect of Quetiapine XR in Depressive Patients Showing Aberrant N100 Amplitude Slope Unknown status NCT01357967 Phase 4 SSRI monotherapy;Seroquel XR adjunctive
20 Aripiprazole in Late Life Bipolar Disorder Completed NCT00194038 Phase 4 Aripiprazole
21 Maintenance Therapies in Bipolar Disorder Completed NCT00227968 Phase 4
22 Add-on Valproate in Late Life Schizophrenia Completed NCT00194025 Phase 4 Valproate
23 A Randomized, Open-label, Trial of Lithium Versus Paroxetine in Subjects With Major Depression Who Have a Family History of Bipolar Disorder or Completed Suicide Completed NCT01416220 Phase 4 Lithium;Paroxetine
24 A Randomized, Sham Controlled, Crossover Trial of rTMS for Bipolar Depression Completed NCT00186758 Phase 4
25 Comparison of Propofol Target-Controlled Infusion Anesthesia and Bolus Injection in Electroconvulsive Therapy: A Randomized Controlled Trial Completed NCT03863925 Phase 4
26 Lamictal for Use in Treatment of Bipolar Disorder In Adults. A Practical Clinical Assessment of Tolerability and Clinical Effectiveness. Completed NCT00067938 Phase 4 lamotrigine
27 A Multi-center, Randomized, Double-blind, Parallel Group, Placebo-controlled 52 Weeks Clinical Trial to Evaluate Efficacy and Safety of Oxcarbazepine p.o.(300-1200 mg/Day) as Adjuvant Therapy in the Bipolar Disorder I or II Treatment Completed NCT00154323 Phase 4 Oxcarbazepine
28 A Randomized, Open Label Trial of Olanzapine Versus Lithium in the Treatment of Acute Depression in Patients With Bipolar II or Bipolar Not Otherwise Specified. Completed NCT02287259 Phase 4 olanzapine;lithium
29 An Open-Label Extension Study to Assess the Safety of Lamotrigine in Subjects With Bipolar Disorder, Who Are in Remission Following a Manic/Hypomanic Index Episode or a Depressive Index Episode. Completed NCT00360126 Phase 4 lamotrigine
30 Lamictal As Add on Treatment in Mixed States of Bipolar Disorder Completed NCT00223509 Phase 4 Lamotrigine
31 Multi-center, Double-blind, Randomized, Comparative Phase 4 Clinical Trial to Evaluate the Efficacy and Safety of Co-administration of Abilify and Depakote in 24-week Treatment of Mania in Patients With Bipolar Disorder Remitted After 6-week Treatment With Abilify and Depakote Completed NCT00545675 Phase 4 Abilify(aripiprazole);Depakote (divalproate)
32 Multi-center, Single Arm, Open Phase IV Clinical Trial to Evaluate the Efficacy and Safety of Co-administration of Abilify With Depakote in the 6-week Treatment of Acute Mania in Patients With Bipolar Disorder Completed NCT00545142 Phase 4 Abilify(Aripiprazole);Depakote(Divalproate)
33 A 52-week, Open-label Extension Study to Evaluate the Safety and Tolerability of Licarbazepine in the Treatment of Manic Episodes of Bipolar I Disorder Completed NCT00139594 Phase 4 licarbazepine
34 Olanzapine Versus Placebo in the Treatment of Mania in Adolescents With Bipolar I Disorder Completed NCT00050206 Phase 4 Olanzapine;Placebo
35 A Randomized, Double-Blind, Placebo Controlled Study Of Quetiapine SR (QTP) As Adjunctive Treatment In Mixed States (MS) Of Bipolar Disorder Completed NCT01195363 Phase 4 quetiapine SR;quetiapine sr placebo
36 Cognitive Enhancement in Bipolar Disorder Completed NCT00597896 Phase 4 pramipexole
37 A Randomized, Double-blind, Placebo-controlled Study of the Efficacy of Ropinirole in the Treatment of Depression in Bipolar Disorder Completed NCT00314821 Phase 4 ropinirole
38 18F-DOPA PET to Elucidate the Antidepressant Mechanism of Lurasidone in Bipolar Disorder Completed NCT03902613 Phase 4 Lurasidone
39 Adjunctive Ziprasidone in Overweight and Obese Patients With Bipolar Disorder Completed NCT00472641 Phase 4 Ziprasidone/Geodon
40 Quetiapine for Bipolar Disorder and Alcohol Dependence Completed NCT00457197 Phase 4 Placebo;Quetiapine
41 Memantine and Cognitive Dysfunction in Bipolar Disorder Completed NCT00586066 Phase 4 Memantine;Placebo
42 A Study of Sertraline to Prevent PTSD Completed NCT00182078 Phase 4 Placebo;Sertraline
43 Olanzapine Plus Carbamazepine Versus Carbamazepine Alone in the Treatment of Manic or Mixed Episodes Associated With Bipolar I Disorder Completed NCT00190892 Phase 4 olanzapine;carbamazepine
44 Olanzapine Versus Active Comparator in the Treatment of Bipolar I Disorder, Manic or Mixed Completed NCT00034580 Phase 4 olanzapine;risperidone
45 Olanzapine/Fluoxetine Combination Versus Lamotrigine in the Treatment of Bipolar I Depression Completed NCT00485771 Phase 4 Olanzapine;Fluoxetine;Lamotrigine
46 Gulf Evaluation of VAlproate (Depakine Chrono) in maNia Study Completed NCT00477373 Phase 4 depakine chrono
47 Adjunctive Topiramate for Treatment of Alcohol Dependence in Patients With Bipolar Disorder Completed NCT00572117 Phase 4 Topiramate
48 A Phase IV STudy of the Effectiveness of Quetiapine Extended Release 600mg Once a Day to Control the Symptoms of Manic Phase of Bipolar Disorder. Completed NCT00521365 Phase 4 Quetiapine 600mg
49 Depakote ER Therapy for Mania Comorbid With Substance Abuse Completed NCT00208195 Phase 4 Divalproex ER
50 Tranylcypromine Treatment of Bipolar Depression Completed NCT01430455 Phase 4 Tranylcypromine

Search NIH Clinical Center for Major Affective Disorder 7

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Carbamazepine
Clonazepam
Clozapine
CLOZAPINE (CARACO)
CLOZAPINE (CLOZARIL)
CLOZAPINE (IVAX)
CLOZAPINE (TEVA)
CLOZAPINE (VERSACLOZ)
Divalproex Sodium
Fazaclo
gabapentin
gabapentin enacarbil
lamotrigine
Lithium
Lithium Aspartate
Lithium Carbonate
lithium citrate
Mylan brand of clozapine
olanzapine
quetiapine
Quetiapine fumarate
Risperidone
Sodium Valproate
tiagabine
Tiagabine hydrochloride
topiramate
UDL brand of clozapine
Valproic Acid

Genetic Tests for Major Affective Disorder 7

Genetic tests related to Major Affective Disorder 7:

# Genetic test Affiliating Genes
1 Major Affective Disorder 7 29 XBP1

Anatomical Context for Major Affective Disorder 7

MalaCards organs/tissues related to Major Affective Disorder 7:

40
Brain, Testes, Eye, Cortex, Heart, Prefrontal Cortex, Kidney

Publications for Major Affective Disorder 7

Articles related to Major Affective Disorder 7:

# Title Authors PMID Year
1
Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder. 56 6
12949534 2003
2
X-box binding protein 1 (XBP1) C--116G polymorphisms in bipolar disorders and age of onset. 6
15331160 2004
3
A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22. 56
11149935 2001
4
Power of the affected-sib-pair method for heterogeneous disorders. 61
3282981 1988

Variations for Major Affective Disorder 7

ClinVar genetic disease variations for Major Affective Disorder 7:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 XBP1 XBP1, -116C-GSNV risk factor 12195
2 XBP1 NM_005080.3(XBP1):c.599+1G>TSNV Uncertain significance 811701 22:29192034-29192034 22:28796046-28796046

Expression for Major Affective Disorder 7

Search GEO for disease gene expression data for Major Affective Disorder 7.

Pathways for Major Affective Disorder 7

GO Terms for Major Affective Disorder 7

Sources for Major Affective Disorder 7

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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