MCID: MJR022
MIFTS: 34

Major Affective Disorder 8

Categories: Mental diseases, Genetic diseases

Aliases & Classifications for Major Affective Disorder 8

MalaCards integrated aliases for Major Affective Disorder 8:

Name: Major Affective Disorder 8 57 73
Major Affective Disorder-8, Susceptibility to 57 13
Bipolar Affective Disorder 57
Major Affective Disorder-8 57
Bipolar Disorder 73
Mafd8 57

Classifications:



External Ids:

OMIM 57 612357
MedGen 42 C2700439
UMLS 73 C2700439

Summaries for Major Affective Disorder 8

MalaCards based summary : Major Affective Disorder 8, also known as major affective disorder-8, susceptibility to, is related to major affective disorder 4 and bipolar disorder. An important gene associated with Major Affective Disorder 8 is MAFD8 (Major Affective Disorder-8, Susceptibility To). The drugs Valproic Acid and Melatonin have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and testes.

Description from OMIM: 612357

Related Diseases for Major Affective Disorder 8

Diseases in the Major Affective Disorder 7 family:

Major Affective Disorder 1 Major Affective Disorder 2
Major Affective Disorder 3 Major Affective Disorder 4
Major Affective Disorder 5 Major Affective Disorder 6
Major Affective Disorder 8 Major Affective Disorder 9

Diseases related to Major Affective Disorder 8 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 major affective disorder 4 12.1
2 bipolar disorder 11.9
3 major affective disorder 2 11.8
4 major affective disorder 5 11.8
5 major affective disorder 6 11.8
6 major affective disorder 7 11.8
7 major affective disorder 9 11.7
8 major affective disorder 1 11.4
9 major affective disorder 3 11.3
10 schizophrenia 10.4
11 depression 10.2
12 dementia 10.0
13 obsessive-compulsive disorder 9.9
14 frontotemporal dementia 9.9
15 thalassemia 9.9
16 frontotemporal dementia with parkinsonism-17 9.9
17 tardive dyskinesia 9.8
18 major depressive disorder 9.8
19 alacrima, achalasia, and mental retardation syndrome 9.8
20 borderline personality disorder 9.8
21 personality disorder 9.8
22 jacobsen syndrome 9.7
23 klippel-trenaunay-weber syndrome 9.7
24 mccune-albright syndrome 9.7
25 schizophrenia 1 9.7
26 autism 9.7
27 hydrocephalus, normal-pressure 9.7
28 schizencephaly 9.7
29 aging 9.7
30 schizophrenia 2 9.7
31 beta-thalassemia 9.7
32 hereditary spastic paraplegia 9.7
33 hydrocephalus 9.7
34 polycystic ovary syndrome 9.7
35 aspiration pneumonia 9.7
36 erythema multiforme 9.7
37 hypogonadotropic hypogonadism 9.7
38 wolfram syndrome 9.7
39 solar retinopathy 9.7
40 neuroleptic malignant syndrome 9.7
41 acromegaly 9.7
42 cerebritis 9.7
43 schizoaffective disorder 9.7
44 pneumonia 9.7
45 paraplegia 9.7
46 adenoma 9.7
47 premenstrual tension 9.7
48 parathyroid adenoma 9.7
49 neuronitis 9.7
50 learning disability 9.7

Graphical network of the top 20 diseases related to Major Affective Disorder 8:



Diseases related to Major Affective Disorder 8

Symptoms & Phenotypes for Major Affective Disorder 8

Clinical features from OMIM:

612357

Drugs & Therapeutics for Major Affective Disorder 8

Drugs for Major Affective Disorder 8 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
2
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
3 Antipsychotic Agents Phase 4
4 Central Nervous System Depressants Phase 4,Phase 3
5 Psychotropic Drugs Phase 4,Phase 3,Phase 1,Phase 2
6 Quetiapine Fumarate Phase 4 111974-72-2
7 Tranquilizing Agents Phase 4,Phase 3
8 Anticonvulsants Phase 4,Phase 3,Phase 2
9 Antidepressive Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
10 Antimanic Agents Phase 4,Phase 3
11 GABA Agents Phase 4
12 Lithium carbonate Phase 4,Phase 3 554-13-2
13 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2
14 Antioxidants Phase 4
15 Protective Agents Phase 4,Phase 2
16
Lamotrigine Approved, Investigational Phase 3 84057-84-1 3878
17
Dopamine Approved Phase 3,Phase 1,Phase 2 51-61-6, 62-31-7 681
18
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
19 calcium channel blockers Phase 3
20 Calcium, Dietary Phase 3
21 Diuretics, Potassium Sparing Phase 3
22 Excitatory Amino Acid Antagonists Phase 3,Phase 2
23 Excitatory Amino Acids Phase 3,Phase 2
24 Sodium Channel Blockers Phase 3
25 Central Nervous System Stimulants Phase 3
26 Dopamine Agents Phase 3,Phase 1,Phase 2
27 Dopamine Uptake Inhibitors Phase 3,Phase 1,Phase 2
28 Neurotransmitter Uptake Inhibitors Phase 3,Phase 1,Phase 2
29
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
30
Tamoxifen Approved Phase 2 10540-29-1 2733526
31
Bupropion Approved Phase 1, Phase 2 34841-39-9, 34911-55-2 444
32
Nicotine Approved Phase 1, Phase 2 54-11-5 942 89594
33
Riluzole Approved, Investigational Phase 2 1744-22-5 5070
34 Antineoplastic Agents, Hormonal Phase 2
35 Bone Density Conservation Agents Phase 2
36 Estrogen Antagonists Phase 2
37 Estrogen Receptor Modulators Phase 2
38 Estrogens Phase 2
39 Hormone Antagonists Phase 2
40 Hormones Phase 2
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
42 Progestins Phase 2
43 Selective Estrogen Receptor Modulators Phase 2
44 Antidepressive Agents, Second-Generation Phase 1, Phase 2
45 Cytochrome P-450 CYP2D6 Inhibitors Phase 1, Phase 2
46 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2
47 Neuroprotective Agents Phase 2
48
Clozapine Approved 5786-21-0 2818
49
Levonorgestrel Approved, Investigational 797-63-7, 17489-40-6 13109
50
Medroxyprogesterone acetate Approved, Investigational 71-58-9

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Efficacy and Safety of Flexible Dose of Quetiapine Fumarate (Seroquel) Switching From Other Drugs in the Treatment of Acute Manic Patients With Bipolar Disorder Unknown status NCT00837343 Phase 4 quetiapine fumarate tablet (Seroquel)
2 Transcranial Magnetic Stimulation in Bipolar Depression Completed NCT00186758 Phase 4
3 Melatonin Versus Placebo for Benzodiazepine Discontinuation in Patients With Schizophrenia Completed NCT01431092 Phase 4 Placebo;Melatonin
4 Safety Study of Depakote Versus Lithium in African Americans With Bipolar Disorder Withdrawn NCT01075126 Phase 4 Depakote;Lithium
5 Prophylactic Effect of Lamotrigine Compared With Lithium in Bipolar Disorder Completed NCT00226135 Phase 3 lithium or lamotrigine
6 Methylphenidate for the Treatment of Acute Mania Completed NCT01541605 Phase 3 methylphenidate;Placebo
7 Cannabidiol as an Adjunctive Treatment for Bipolar Depression Recruiting NCT03310593 Phase 2, Phase 3 Cannabidiol;Placebo
8 rTMS in the Treatment of Bipolar Depression Unknown status NCT00436020 Phase 2
9 Anti-Estrogens - A Potential Treatment for Bipolar Affective Disorder in Women? Completed NCT00206544 Phase 2 Tamoxifen;Progesterone
10 A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Affective Disorder Completed NCT00593099 Phase 1, Phase 2 Bupropion;Placebo
11 Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar Disorder Terminated NCT00805493 Phase 2 Riluzole
12 Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder Withdrawn NCT00327756 Phase 2 Coenzyme Q10
13 Myths About Bipolar Affective Disorder: The Role of Structured Group Psychoeducation Therapy Unknown status NCT00474357 Not Applicable
14 Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder (PGBD) Unknown status NCT01272531 Mood stabilizer treatment
15 Neurophysiologic Correlates of Hypersomnia Unknown status NCT01719315
16 A Study of the Association Between Tobacco Smoking and Bipolar Affective Disorder Completed NCT00741299
17 Exercise for Depression Completed NCT02874833 Not Applicable
18 Bipolar Research Study Using MR Imaging Completed NCT02083978
19 Specialized Clozapine Clinic for Bipolar and Schizoaffective Disorder Completed NCT00683709
20 Bipolar Intervention Study: Cognitive Interpersonal Therapy Completed NCT01315028 Not Applicable
21 Genetic Aspects of Neurologic and Psychiatric Disorders Completed NCT00001544
22 Early Integrated Intervention in Severe Affective Disorders Completed NCT00253071 Not Applicable
23 The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels Completed NCT01385709
24 Blister Packaging Medication to Increase Treatment Adherence and Clinical Response Completed NCT01118208 Not Applicable
25 Transcranial Direct Current Stimulation Apparatus for Domiciliary Use Completed NCT02408237 Not Applicable
26 European Comparative Effectiveness Research on Internet-based Depression Treatment Completed NCT02542891 Not Applicable
27 Study of the Psychological Development of Children of Parents With and Without Affective Disorders Completed NCT00001170
28 Study of Sensorimotor Compatibility Effects in Bipolar Affective Disorder. Recruiting NCT03249857 Not Applicable
29 Evaluation of an App for Smartphones for People With a Bipolar Affective Disorder Recruiting NCT03275714 Not Applicable
30 Home-based Transcranial Direct Current Stimulation in Fibromyalgia Patients Recruiting NCT02652988 Not Applicable
31 Improving Work Outcome for People With Severe Mental Illness Active, not recruiting NCT01722344 Not Applicable
32 Somatic Comorbidities in Psychiatric Patients Active, not recruiting NCT02773108
33 The Potential Efficacy of the Chinese Health Improvement Profile- A Pilot Clustered Randomised Controlled Trial Active, not recruiting NCT02453217 Not Applicable
34 A Study of Aerobic Exercise for Patients With Bipolar Disorder Not yet recruiting NCT03353337 Not Applicable
35 Psychiatric Disorders and Electrophysiological Markers Not yet recruiting NCT02329119 Not Applicable
36 Cannabinoids in Bipolar Affective Disorder Withdrawn NCT00397605 Not Applicable Synthetic cannabinoids (1:1 ratio of THC % CBD)

Search NIH Clinical Center for Major Affective Disorder 8

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Major Affective Disorder 8

Anatomical Context for Major Affective Disorder 8

MalaCards organs/tissues related to Major Affective Disorder 8:

41
Brain, Bone, Testes, Cortex, Amygdala, Ovary, Prefrontal Cortex

Publications for Major Affective Disorder 8

Articles related to Major Affective Disorder 8:

(show top 50) (show all 257)
# Title Authors Year
1
Polycystic Ovary Syndrome in Bipolar Affective Disorder: A Hospital-based Study. ( 29962567 )
2018
2
Polydipsia as a Precursor of Manic Episode in Bipolar Affective Disorder Patients with Alcohol Use Disorder. ( 29397674 )
2018
3
A Rare Presentation of a Case of Obsessive-compulsive Disorder Comorbid with Bipolar Affective Disorder. ( 29284814 )
2017
4
Predictors of rehospitalization in a naturalistic cohort of patients with bipolar affective disorder. ( 28207568 )
2017
5
Soluble Intracellular Adhesion Molecule-1 in Patients with Unipolar or Bipolar Affective Disorders: Results from a Pilot Trial. ( 27442531 )
2016
6
DGKH genetic risk variant influences gene expression in bipolar affective disorder. ( 27016658 )
2016
7
Comparative neuropsychiatry: white matter abnormalities in children and adolescents with schizophrenia, bipolar affective disorder, and obsessive-compulsive disorder. ( 25498242 )
2015
8
Frontotemporal dementia mimicking bipolar affective disorder, normal pressure hydrocephalus and KlA1ver-Bucy syndrome. ( 26482719 )
2015
9
Influence of DGKH variants on amygdala volume in patients with bipolar affective disorder and schizophrenia. ( 24958494 )
2015
10
Fluctuating capacity and advance decision-making in Bipolar Affective Disorder - Self-binding directives and self-determination. ( 25939286 )
2015
11
Pharmacotherapy of Bipolar Affective Disorder: A Hospital based Study from Sub Himalayan Valley of Nepal. ( 25121003 )
2014
12
Disruption of sonic hedgehog signaling in Ellis-van Creveld dwarfism confers protection against bipolar affective disorder. ( 25311364 )
2014
13
Brain-derived neurotrophic factor (BDNF)-epigenetic regulation in unipolar and bipolar affective disorder. ( 25106037 )
2014
14
De novo CNVs in bipolar affective disorder and schizophrenia. ( 25055870 )
2014
15
Analysis of genetic association and epistasis interactions between circadian clock genes and symptom dimensions of bipolar affective disorder. ( 24673294 )
2014
16
Association analysis of genes in serotonin pathway with attention and executive function in patients with bipolar affective disorder. ( 25200194 )
2014
17
Olanzapine-induced neuroleptic malignant syndrome in a patient with bipolar affective disorder: Does quetiapine holds the solution? ( 25013321 )
2013
18
Contribution of methotrexate in precipitation of manic episode in bipolar affective disorder explored: a case report. ( 24167698 )
2013
19
Can we prevent under-diagnosis and misdiagnosis of bipolar affective disorder? Repeat audits to assess the epidemiological change in the caseload of a community mental health team when bipolar disorder is accurately assessed and diagnosed. ( 23995161 )
2013
20
[Cognitive functioning in depression and the course of bipolar affective disorder]. ( 23888758 )
2013
21
No association between serum cholesterol and death by suicide in patients with schizophrenia, bipolar affective disorder, or major depressive disorder. ( 24308827 )
2013
22
Bipolar affective disorder preceding frontotemporal dementia in a patient with C9ORF72 mutation: is there a genetic link between these two disorders? ( 23314407 )
2013
23
A case of bipolar affective disorder and aspiration pneumonia. ( 23956911 )
2013
24
Sodium Valproate induced priapism in an adult with bipolar affective disorder. ( 24347777 )
2013
25
Mental state deterioration after switching from brand-name to generic olanzapine in an adolescent with bipolar affective disorder, autism and intellectual disability: a case study. ( 24094081 )
2013
26
Bipolar affective disorder and early dementia onset in a male patient with SHANK3 deletion. ( 22922660 )
2012
27
Replication of functional serotonin receptor type 3A and B variants in bipolar affective disorder: a European multicenter study. ( 22832903 )
2012
28
A follow-up study of family burden in patients with bipolar affective disorder. ( 21421638 )
2012
29
Borderline personality disorder and bipolar affective disorder. Spectra or spectre? A review. ( 22508593 )
2012
30
Analysis of association between common SNPs in ErbB4 and bipolar affective disorder, major depressive disorder and schizophrenia in the Han Chinese population. ( 21993442 )
2012
31
Differential diagnosis of bipolar affective disorder type II and borderline personality disorder: analysis of the affective dimension. ( 22560773 )
2012
32
Tests of linkage and allelic association between markers in the 1p36 PRKCZ (protein kinase C zeta) gene region and bipolar affective disorder. ( 22231931 )
2012
33
Quinacrine induced mood disturbance--the unmasking of bipolar affective disorder. ( 22729334 )
2012
34
Gender-specific association of TSNAX/DISC1 locus for schizophrenia and bipolar affective disorder in South Indian population. ( 22673686 )
2012
35
Carbamazepine-induced erythema multiforme major in an epileptic patient with bipolar affective disorder. ( 22629103 )
2012
36
Haloperidol induced obsessive compulsive symptom (OCS) in a patient with learning disability and bipolar affective disorder. ( 22605593 )
2012
37
Atypical presentation of tardive dyskinesia associated with risperidone long-acting injection as maintenance treatment in bipolar affective disorder: a case report. ( 22663952 )
2012
38
Comorbid bipolar affective disorder and obsessive compulsive disorder in childhood: a case study and brief review. ( 23440037 )
2012
39
MAGI1 copy number variation in bipolar affective disorder and schizophrenia. ( 22381734 )
2012
40
Development of frontotemporal dementia in a case of bipolar affective disorder: is there a link? ( 22714610 )
2011
41
Cognitions in bipolar affective disorder and unipolar depression: imagining suicide. ( 22085478 )
2011
42
Genetic association and sequencing of the insulin-like growth factor 1 gene in bipolar affective disorder. ( 21302346 )
2011
43
Chronic somatic comorbidity and excess mortality due to natural causes in persons with schizophrenia or bipolar affective disorder. ( 21935426 )
2011
44
The seasonality of bipolar affective disorder: comparison with a primary care sample using the Seasonal Pattern Assessment Questionnaire. ( 21377212 )
2011
45
A systematic association mapping on chromosome 6q in bipolar affective disorder--evidence for the melanin-concentrating-hormone-receptor-2 gene as a risk factor for bipolar affective disorder. ( 19927306 )
2010
46
Nuclear receptor rev-erb-{alpha} circadian gene variants and lithium carbonate prophylaxis in bipolar affective disorder. ( 20348464 )
2010
47
Support for a bipolar affective disorder susceptibility locus on chromosome 12q24.3. ( 20410851 )
2010
48
Effect of fasting during Ramadan on serum lithium level and mental state in bipolar affective disorder. ( 20827213 )
2010
49
Midline brain abnormalities in established bipolar affective disorder. ( 19782407 )
2010
50
Autonomic nervous system in euthymic patients with bipolar affective disorder. ( 21196931 )
2010

Variations for Major Affective Disorder 8

Expression for Major Affective Disorder 8

Search GEO for disease gene expression data for Major Affective Disorder 8.

Pathways for Major Affective Disorder 8

GO Terms for Major Affective Disorder 8

Sources for Major Affective Disorder 8

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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