MAFD9
MCID: MJR024
MIFTS: 36

Major Affective Disorder 9 (MAFD9)

Categories: Genetic diseases, Mental diseases

Aliases & Classifications for Major Affective Disorder 9

MalaCards integrated aliases for Major Affective Disorder 9:

Name: Major Affective Disorder 9 58 13 74
Major Affective Disorder-9, Susceptibility to 58
Bipolar Affective Disorder 58
Major Affective Disorder-9 58
Bipolar Disorder 74
Mafd9 58

Classifications:



External Ids:

OMIM 58 612372
MedGen 43 C2700440

Summaries for Major Affective Disorder 9

MalaCards based summary : Major Affective Disorder 9, also known as major affective disorder-9, susceptibility to, is related to major affective disorder 1 and bipolar disorder. An important gene associated with Major Affective Disorder 9 is MAFD9 (Major Affective Disorder-9, Susceptibility To). The drugs Valproic Acid and Lithium carbonate have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and cortex.

Description from OMIM: 612372

Related Diseases for Major Affective Disorder 9

Diseases in the Major Affective Disorder 1 family:

Major Affective Disorder 2 Major Affective Disorder 3
Major Affective Disorder 4 Major Affective Disorder 5
Major Affective Disorder 6 Major Affective Disorder 8
Major Affective Disorder 7 Major Affective Disorder 9

Diseases related to Major Affective Disorder 9 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 major affective disorder 1 12.3
2 bipolar disorder 12.1
3 major affective disorder 7 12.0
4 major affective disorder 8 11.9
5 major affective disorder 2 11.8
6 major affective disorder 4 11.8
7 major affective disorder 5 11.8
8 major affective disorder 6 11.8
9 major affective disorder 3 11.5
10 schizophrenia 10.7
11 depression 10.4
12 tardive dyskinesia 10.2
13 personality disorder 10.2
14 multiple sclerosis 10.2
15 obsessive-compulsive disorder 10.2
16 major depressive disorder 10.2
17 disease of mental health 10.1
18 endogenous depression 10.1
19 thalassemia 10.1
20 dementia 10.1
21 substance abuse 10.1
22 frontotemporal dementia 10.0
23 alacrima, achalasia, and mental retardation syndrome 10.0
24 borderline personality disorder 10.0
25 hypothyroidism 10.0
26 mental depression 10.0
27 head injury 10.0
28 autism 9.9
29 orthostatic intolerance 9.9
30 beta-thalassemia 9.9
31 hydrocephalus 9.9
32 conn's syndrome 9.9
33 schizoaffective disorder 9.9
34 adenoma 9.9
35 periodontitis 9.9
36 cyclothymic disorder 9.9
37 learning disability 9.9
38 congenital hydrocephalus 9.9
39 darier-white disease 9.8
40 huntington disease 9.8
41 jacobsen syndrome 9.8
42 klippel-trenaunay-weber syndrome 9.8
43 lithium transport 9.8
44 mccune-albright syndrome 9.8
45 pulmonary fibrosis, idiopathic 9.8
46 schizophrenia 1 9.8
47 cerebrotendinous xanthomatosis 9.8
48 wolfram syndrome 1 9.8
49 hydrocephalus, normal-pressure 9.8
50 schizencephaly 9.8

Comorbidity relations with Major Affective Disorder 9 via Phenotypic Disease Network (PDN):


Acute Cystitis Bipolar Disorder
Deficiency Anemia Heart Disease
Hypertension, Essential Hypothyroidism
Major Depressive Disorder Parkinson Disease, Late-Onset
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Major Affective Disorder 9:



Diseases related to Major Affective Disorder 9

Symptoms & Phenotypes for Major Affective Disorder 9

Clinical features from OMIM:

612372

Drugs & Therapeutics for Major Affective Disorder 9

Drugs for Major Affective Disorder 9 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
2
Lithium carbonate Approved Phase 4,Phase 3 554-13-2
3
Succinylcholine Approved Phase 4 306-40-1 5314
4
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
5
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
6
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
7 Tranquilizing Agents Phase 4,Phase 3
8 Psychotropic Drugs Phase 4,Phase 3,Phase 1,Phase 2
9 Antidepressive Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
10 Central Nervous System Depressants Phase 4,Phase 3
11 Quetiapine Fumarate Phase 4 111974-72-2
12 Antipsychotic Agents Phase 4,Phase 3
13 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2
14 GABA Agents Phase 4
15 Antimanic Agents Phase 4,Phase 3
16 Anticonvulsants Phase 4,Phase 3,Phase 2
17 Antioxidants Phase 4
18 Protective Agents Phase 4,Phase 2
19 Anesthetics, Intravenous Phase 4
20 Hypnotics and Sedatives Phase 4
21 Anesthetics, General Phase 4
22 Anesthetics Phase 4
23 Excitatory Amino Acid Antagonists Phase 4,Phase 2
24 Peripheral Nervous System Agents Phase 4
25 Anesthetics, Dissociative Phase 4
26 Analgesics Phase 4
27 Excitatory Amino Acids Phase 4,Phase 2
28
Lamotrigine Approved, Investigational Phase 3 84057-84-1 3878
29
Dopamine Approved Phase 3,Phase 1,Phase 2 62-31-7, 51-61-6 681
30
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
31
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
32 calcium channel blockers Phase 3
33 Diuretics, Potassium Sparing Phase 3
34 Sodium Channel Blockers Phase 3
35 Calcium, Dietary Phase 3
36 Hormones Phase 3,Phase 2
37 Dopamine Uptake Inhibitors Phase 3,Phase 1,Phase 2
38 Neurotransmitter Uptake Inhibitors Phase 3,Phase 1,Phase 2
39 Central Nervous System Stimulants Phase 3
40 Dopamine Agents Phase 3,Phase 1,Phase 2
41 Epidiolex Phase 2, Phase 3
42
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
43
Tamoxifen Approved Phase 2 10540-29-1 2733526
44
Nicotine Approved Phase 1, Phase 2 54-11-5 89594 942
45
Bupropion Approved Phase 1, Phase 2 34841-39-9, 34911-55-2 444
46
Riluzole Approved, Investigational Phase 2 1744-22-5 5070
47 Antineoplastic Agents, Hormonal Phase 2
48 Hormone Antagonists Phase 2
49 Selective Estrogen Receptor Modulators Phase 2
50 Estrogen Antagonists Phase 2

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Efficacy and Safety of Flexible Dose of Quetiapine Fumarate (Seroquel) Switching From Other Drugs in the Treatment of Acute Manic Patients With Bipolar Disorder Unknown status NCT00837343 Phase 4 quetiapine fumarate tablet (Seroquel)
2 Transcranial Magnetic Stimulation in Bipolar Depression Completed NCT00186758 Phase 4
3 Melatonin Versus Placebo for Benzodiazepine Discontinuation in Patients With Schizophrenia Completed NCT01431092 Phase 4 Placebo;Melatonin
4 Comparison of Propofol Target-Controlled Infusion Anesthesia and Bolus Injection in Electroconvulsive Therapy Completed NCT03863925 Phase 4
5 Clinical Utility of Pharmacogenomics of Psychotropic Medications Not yet recruiting NCT03907124 Phase 4 Genetically-guided treatment with FDA-approved psychotropic drugs;Treatment as usual (TAU)
6 Comparison of Ketamine Combine Propofol vs Propofol Anesthesia in Schizophrenia Electroconvulsive Therapy Not yet recruiting NCT03829124 Phase 4 Propofol;Ketamine
7 Safety Study of Depakote Versus Lithium in African Americans With Bipolar Disorder Withdrawn NCT01075126 Phase 4 Depakote;Lithium
8 Prophylactic Effect of Lamotrigine Compared With Lithium in Bipolar Disorder Completed NCT00226135 Phase 3 lithium or lamotrigine
9 Methylphenidate for the Treatment of Acute Mania Completed NCT01541605 Phase 3 methylphenidate;Placebo
10 Cannabidiol as an Adjunctive Treatment for Bipolar Depression Recruiting NCT03310593 Phase 2, Phase 3 Cannabidiol;Placebo
11 rTMS in the Treatment of Bipolar Depression Unknown status NCT00436020 Phase 2
12 Anti-Estrogens - A Potential Treatment for Bipolar Affective Disorder in Women? Completed NCT00206544 Phase 2 Tamoxifen;Progesterone
13 A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Affective Disorder Completed NCT00593099 Phase 1, Phase 2 Bupropion;Placebo
14 Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar Disorder Terminated NCT00805493 Phase 2 Riluzole
15 Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder Withdrawn NCT00327756 Phase 2 Coenzyme Q10
16 Myths About Bipolar Affective Disorder: The Role of Structured Group Psychoeducation Therapy Unknown status NCT00474357 Not Applicable
17 Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder (PGBD) Unknown status NCT01272531 Mood stabilizer treatment
18 Psychiatric Disorders and Electrophysiological Markers Unknown status NCT02329119 Not Applicable
19 A Study of the Association Between Tobacco Smoking and Bipolar Affective Disorder Completed NCT00741299
20 Exercise for Depression Completed NCT02874833 Not Applicable
21 Bipolar Research Study Using MR Imaging Completed NCT02083978
22 Specialized Clozapine Clinic for Bipolar and Schizoaffective Disorder Completed NCT00683709
23 Bipolar Intervention Study: Cognitive Interpersonal Therapy Completed NCT01315028 Not Applicable
24 Genetic Aspects of Neurologic and Psychiatric Disorders Completed NCT00001544
25 Early Integrated Intervention in Severe Affective Disorders Completed NCT00253071 Not Applicable
26 The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels Completed NCT01385709
27 Blister Packaging Medication to Increase Treatment Adherence and Clinical Response Completed NCT01118208 Not Applicable
28 Home-based Transcranial Direct Current Stimulation in Fibromyalgia Patients Completed NCT02652988 Not Applicable
29 Transcranial Direct Current Stimulation Apparatus for Domiciliary Use Completed NCT02408237 Not Applicable
30 The Potential Efficacy of the Chinese Health Improvement Profile- A Pilot Clustered Randomised Controlled Trial Completed NCT02453217 Not Applicable
31 European Comparative Effectiveness Research on Internet-based Depression Treatment Completed NCT02542891 Not Applicable
32 Study of the Psychological Development of Children of Parents With and Without Affective Disorders Completed NCT00001170
33 Neurophysiologic Correlates of Hypersomnia Completed NCT01719315
34 Study of Sensorimotor Compatibility Effects in Bipolar Affective Disorder. Recruiting NCT03249857 Not Applicable
35 Evaluation of an App for Smartphones for People With a Bipolar Affective Disorder Recruiting NCT03275714 Not Applicable
36 Electronic Communication Augmented Mental Health Care Recruiting NCT03925038 Not Applicable
37 Improving Work Outcome for People With Severe Mental Illness Active, not recruiting NCT01722344 Not Applicable
38 Somatic Comorbidities in Psychiatric Patients Active, not recruiting NCT02773108
39 A Study of Aerobic Exercise for Patients With Bipolar Disorder Not yet recruiting NCT03353337 Not Applicable
40 Cannabinoids in Bipolar Affective Disorder Withdrawn NCT00397605 Not Applicable Synthetic cannabinoids (1:1 ratio of THC % CBD)

Search NIH Clinical Center for Major Affective Disorder 9

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Major Affective Disorder 9

Anatomical Context for Major Affective Disorder 9

MalaCards organs/tissues related to Major Affective Disorder 9:

42
Brain, Thyroid, Cortex, Pituitary, Bone, Testes, Amygdala

Publications for Major Affective Disorder 9

Articles related to Major Affective Disorder 9:

(show top 50) (show all 788)
# Title Authors Year
1
Hormonal imbalance and pituitary adenoma during antipsychotic treatment in an adolescent with bipolar affective disorder. ( 30760936 )
2019
2
Bipolar affective disorder and borderline personality disorder: Differentiation based on the history of early life stress and psychoneuroendocrine measures. ( 29702176 )
2019
3
Add-on HD-tDCS for obsessive-compulsive disorder with comorbid bipolar affective disorder: A case series. ( 31108398 )
2019
4
Working Memory in Patients with Schizophrenia and Bipolar Affective Disorder: Quantitative or Qualitative Differences? ( 30948690 )
2019
5
Clinical Practice Guidelines for Bipolar Affective Disorder (BPAD) in Children and Adolescents. ( 30745704 )
2019
6
A case report of cholinergic rebound syndrome following abrupt low-dose clozapine discontinuation in a patient with type I bipolar affective disorder. ( 30782143 )
2019
7
Predominant Polarity in Bipolar Affective Disorder: A Scoping Review of Its Relationship with Clinical Variables and Its Implications. ( 30783303 )
2019
8
Stressful Life Events and Relapse in Bipolar Affective Disorder: A Cross-Sectional Study from a Tertiary Care Center of Southern India. ( 30783310 )
2019
9
Comments on "Stressful Life Events and Relapse in Bipolar Affective Disorder". ( 30983677 )
2019
10
Lithium-induced Symptomatic Hypercalcemia and Hyperparathyroidism in a Patient with Bipolar Affective Disorder: A Case Report and Review of Literature. ( 30093752 )
2018
11
Novel functional variants at the GWAS-implicated loci might confer risk to major depressive disorder, bipolar affective disorder and schizophrenia. ( 29745862 )
2018
12
Corrigendum to "Analysis of association between common SNPs in ErbB4 and bipolar affective disorder, major depressive disorder and schizophrenia in the Han Chinese population" [Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 36 (2012) 17-21]. ( 28803680 )
2018
13
Polycystic Ovary Syndrome in Bipolar Affective Disorder: A Hospital-based Study. ( 29962567 )
2018
14
Functional magnetic resonance spectroscopy in patients with schizophrenia and bipolar affective disorder: Glutamate dynamics in the anterior cingulate cortex during a working memory task. ( 30558824 )
2018
15
Lithium-induced Thyroiditis in a Patient Having Bipolar Affective Disorder - A Rare Case Report. ( 30533956 )
2018
16
Polydipsia as a Precursor of Manic Episode in Bipolar Affective Disorder Patients with Alcohol Use Disorder. ( 29397674 )
2018
17
Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study. ( 29121268 )
2018
18
Effectiveness of Mindfulness-based Cognitive Therapy in Patients with Bipolar Affective Disorder: A Case Series. ( 29343935 )
2018
19
Assessing Caregiver Burden in Caregivers of Patients with Schizophrenia and Bipolar Affective Disorder in Kathmandu Medical College. ( 29353899 )
2018
20
Bipolar Affective Disorder in a Patient of Profound Deafness. ( 29482712 )
2018
21
Managing Bipolar Affective Disorder in a Tribal District of Odisha. ( 29875526 )
2018
22
Neuropsychological Functioning in Euthymic Phase of Bipolar Affective Disorder. ( 29875527 )
2018
23
A gene co-expression module implicating the mitochondrial electron transport chain is associated with long-term response to lithium treatment in bipolar affective disorder. ( 30185780 )
2018
24
The temperament and character traits in patients with major depressive disorder and bipolar affective disorder with and without suicide attempt. ( 28636575 )
2017
25
A Rare Presentation of a Case of Obsessive-compulsive Disorder Comorbid with Bipolar Affective Disorder. ( 29284814 )
2017
26
Outcomes of Renal Transplantation in Patients With Bipolar Affective Disorder and Schizophrenia: A National Retrospective Cohort Study. ( 27887740 )
2017
27
Identification of rare nonsynonymous variants in SYNE1/CPG2 in bipolar affective disorder. ( 28178086 )
2017
28
Predictors of rehospitalization in a naturalistic cohort of patients with bipolar affective disorder. ( 28207568 )
2017
29
Adverse events associated with mood stabiliser treatment should be continuously monitored in patients diagnosed with bipolar affective disorder. ( 28254753 )
2017
30
The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment. ( 28289283 )
2017
31
Bipolar affective disorder and childhood adversity: possible genetic links? ( 28465388 )
2017
32
Schizophrenia and Bipolar Affective Disorder: a Dimensional Approach. ( 28636571 )
2017
33
High-dose levothyroxine for the management of bipolar affective disorder: two case reports. ( 28904805 )
2017
34
A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia. ( 29049482 )
2017
35
Impact of Pharmacist-Psychiatrist Collaborative Patient Education on Medication Adherence and Quality of Life (QOL) of Bipolar Affective Disorder (BPAD) Patients. ( 29066976 )
2017
36
Prevalence and Sociodemographic Profile of Lithium-induced Cutaneous Side Effects in Bipolar Affective Disorder Patients: A 1-year Prospective Observational Study in South India. ( 29200562 )
2017
37
Positive Aspects of Caregiving and Its Correlates among Caregivers of Bipolar Affective Disorder. ( 29259143 )
2017
38
Bipolar affective disorder and its impact on various aspects of marital relationship. ( 30089956 )
2017
39
Cardiac (123)I-meta-iodo-benzyl-guanine in a patient with bipolar affective disorder, musical hallucinations and Parkinsonism. ( 26346109 )
2016
40
Abnormal early brain responses during visual search are evident in schizophrenia but not bipolar affective disorder. ( 26603466 )
2016
41
Can Psychological, Social and Demographical Factors Predict Clinical Characteristics Symptomatology of Bipolar Affective Disorder and Schizophrenia? ( 26646576 )
2016
42
DGKH genetic risk variant influences gene expression in bipolar affective disorder. ( 27016658 )
2016
43
Disability and Quality of Life of Subjects with Bipolar Affective Disorder in Remission. ( 27570346 )
2016
44
Are SSRIs responsible for precipitating suicidal ideation in teenagers with 'subsyndromal' bipolar affective disorder who have been misdiagnosed with unipolar depression? ( 27663811 )
2016
45
Hospital treatment, mortality and healthcare costs in relation to socioeconomic status among people with bipolar affective disorder. ( 27703748 )
2016
46
Relationship between childhood adversity and bipolar affective disorder: systematic review and meta-analysis. ( 27758835 )
2016
47
CASE-REPORT Case study of a patient presenting both type II bipolar affective disorder and Klinefelter syndrome. ( 27813593 )
2016
48
Distressing cutaneous lesion among bipolar affective disorder patients on lithium therapy: A retrospective cross-sectional study. ( 28196994 )
2016
49
Selective impairment of global motion integration, but not global form detection, in schizophrenia and bipolar affective disorder. ( 28740802 )
2016
50
Disruption of sonic hedgehog signaling in Ellis-van Creveld dwarfism confers protection against bipolar affective disorder. ( 25311364 )
2015

Variations for Major Affective Disorder 9

Expression for Major Affective Disorder 9

Search GEO for disease gene expression data for Major Affective Disorder 9.

Pathways for Major Affective Disorder 9

GO Terms for Major Affective Disorder 9

Sources for Major Affective Disorder 9

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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