Major Depressive Disorder (MDD)

Categories: Genetic diseases, Mental diseases, Neuronal diseases

Aliases & Classifications for Major Depressive Disorder

MalaCards integrated aliases for Major Depressive Disorder:

Name: Major Depressive Disorder 57 12 75 74 37 29 6 15 40 72
Seasonal Affective Disorder 57 12 75 25 74 55 43 44 15 72
Unipolar Depression 57 74 55 17 72
Major Depressive Disorder, Response to Citalopram Therapy in 57 6
Unipolar Depression, Susceptibility to 57 6
Single Major Depressive Episode 12 72
Major Depressive Disorder 1 57 72
Major Depressive Disorder 2 57 72
Winter Depression 12 72
Mdd 57 74
Sad 25 74
Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment 57
Major Depressive Disorder with a Seasonal Pattern 25
Seasonal Affective Disorder, Susceptibility to 57
Recurrent Major Depressive Episodes 72
Depression in a Seasonal Pattern 25
Affective Disorder, Seasonal 25
Recurrent Major Depression 12
Depressive Disorder, Major 44
Seasonal Mood Disorder 25
Depression; Seasonal 25
Seasonal Depression 25


External Ids:

Disease Ontology 12 DOID:0060167 DOID:1470
OMIM 57 608516
KEGG 37 H01646
NCIt 50 C34796
SNOMED-CT 68 36923009 66344007
UMLS 72 C0024517 C0041696 C0085159 more

Summaries for Major Depressive Disorder

Genetics Home Reference : 25 Seasonal affective disorder is a mental health condition that is triggered by the changing of the seasons. This condition is a subtype of major depressive disorder and bipolar disorder. Major depressive disorder is characterized by prolonged sadness and a general lack of interest, while bipolar disorder is characterized by similar depressive episodes alternating with periods of abnormally high energy and activity (hypomania or mania). People with seasonal affective disorder have signs and symptoms of either major depressive disorder or bipolar disorder only during certain months of the year. Major depressive disorder is more common than bipolar disorder among people with seasonal affective disorder. This condition usually begins in a person's twenties or thirties. The signs and symptoms that occur during depressive episodes in people with seasonal affective disorder are similar to those of major depressive disorder, including a loss of interest or enjoyment in activities, a decrease in energy, a depressed mood, and low self-esteem. In most people with seasonal affective disorder, depression and other features appear in the fall and winter months and subside in the spring and summer months. In these individuals, additional symptoms often include weight gain due to increased cravings for carbohydrates and an increase in sleep (hypersomnia). Affected individuals with underlying bipolar disorder typically have alternating episodes of depression in the fall and winter months and mania during the spring and summer months. In about 10 percent of people with seasonal affective disorder, the condition has the opposite seasonal pattern, occurring in the spring and summer months and stopping during the fall and winter months. These individuals usually have a loss of appetite and sleep, unlike those with symptoms in the fall and winter. For those affected, it is estimated that symptoms of seasonal affective disorder are present during 40 percent of the year. In some individuals, seasonal affective disorder does not recur every year. Thirty to 50 percent of affected individuals do not show symptoms of the disorder in consecutive winters. In about 40 percent of individuals with seasonal affective disorder, depressive episodes continue after winter and do not alleviate in the summer months, leading to a change in diagnosis to either major depressive disorder or bipolar disorder. Individuals with seasonal affective disorder tend to have another psychological condition, such as attention-deficit/hyperactivity disorder (ADHD), an eating disorder, anxiety disorder, or panic disorder.

MalaCards based summary : Major Depressive Disorder, also known as seasonal affective disorder, is related to depression and endogenous depression, and has symptoms including mental and behavioral signs and symptoms and depressive symptoms. An important gene associated with Major Depressive Disorder is HTR2A (5-Hydroxytryptamine Receptor 2A), and among its related pathways/superpathways are Serotonergic synapse and Neuroscience. The drugs Etomidate and Valsartan have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related phenotype is behavior/neurological.

Disease Ontology : 12 An endogenous depression that is characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities.

MedlinePlus : 43 Seasonal affective disorder (SAD) is a type of depression that comes and goes with the seasons. It usually starts in the late fall and early winter and goes away during the spring and summer. Some people do have episodes of depression that start in the spring or summer, but that is a lot less common. Symptoms of SAD may include Sadness Gloomy outlook Feeling hopeless, worthless, and irritable Loss of interest or pleasure in activities you used to enjoy Low energy Difficulty sleeping or oversleeping Carbohydrate cravings and weight gain Thoughts of death or suicide SAD is more common in women, young people, and those who live far from the equator. You are also more likely to have SAD if you or your family members have depression. The exact causes of SAD are unknown. Researchers have found that people with SAD may have an imbalance of serotonin, a brain chemical that affects your mood. Their bodies also make too much melatonin, a hormone that regulates sleep, and not enough vitamin D. The main treatment for SAD is light therapy. The idea behind light therapy is to replace the sunshine that you miss during the fall and winter months. You sit in front of a light therapy box every morning to get daily exposure to bright, artificial light. But some people with SAD do not respond to light therapy alone. Antidepressant medicines and talk therapy can reduce SAD symptoms, either alone or combined with light therapy. NIH: National Institute of Mental Health

KEGG : 37
Major depressive disorder (MDD) is the most common psychiatric disorder mainly characterized by depressed mood, loss of interest, feelings of worthlessness, and a high risk of suicide. Accumulated evidence suggests that both environmental and genetic factors are involved in the etiology of MDD although the pathogenesis of MDD remains unknown. Mutations in genes involved in brain serotonin synthesis, have been identified in patients. Brain serotonin deficiency has been hypothesized to play a role in a wide range of psychiatric diseases, including MDD. Several efficacious treatments for MDD are available, including different forms of psychotherapy and antidepressant medication. Recently, selective reuptake inhibitors (SSRIs, SNRIs,) have become the first-line antidepressant drug treatment of depression and replaced tricyclic antidepressants (TCA) and monoamine oxidase inhibitors (MAOI) due to fewer side-effects and ease of use.

UniProtKB/Swiss-Prot : 74 Major depressive disorder: A common psychiatric disorder. It is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning.

Wikipedia : 75 Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by... more...

More information from OMIM: 608516

Related Diseases for Major Depressive Disorder

Diseases in the Major Depressive Disorder family:

Major Depressive Disorder 1 Major Depressive Disorder 2

Diseases related to Major Depressive Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 569)
# Related Disease Score Top Affiliating Genes
1 depression 33.8 TPH2 TPH1 SLC6A4 HTR2A HTR1A DISC2
2 endogenous depression 33.8 TPH1 SLC6A4 HTR2A HTR1A CRH BDNF
3 mental depression 33.7 TPH2 TPH1 SLC6A4 HTR2A HTR1A FKBP5
4 anxiety 33.7 TPH2 TPH1 SLC6A4 HTR2A HTR1A CRH
5 generalized anxiety disorder 32.6 TPH1 SLC6A4 HTR2A HTR1A BDNF
6 personality disorder 32.5 TPH1 SLC6A4 HTR2A HTR1A DRD4 BDNF
7 panic disorder 32.5 TPH2 SLC6A4 HTR2A HTR1A CRH
8 dysthymic disorder 32.3 SLC6A4 HTR2A
9 avoidant personality disorder 32.3 TPH1 SLC6A4
10 borderline personality disorder 32.2 TPH2 TPH1 SLC6A4 HTR2A HTR1A BDNF
11 bipolar i disorder 32.2 SLC6A4 HTR2A HTR1A BDNF
12 post-traumatic stress disorder 32.1 SLC6A4 HTR2A FKBP5 CRH BDNF APOE
13 alcohol dependence 32.1 TPH2 TPH1 SLC6A4 HTR2A HTR1A DRD4
14 migraine with or without aura 1 32.1 TPH1 SLC6A4 HTR2A HTR1A
15 substance abuse 32.1 SLC6A4 DRD4 BDNF
16 atypical depressive disorder 32.1 SLC6A4 HTR2A CRH
17 obsessive-compulsive disorder 32.0 TPH2 TPH1 SLC6A4 HTR2A HTR1A DRD4
18 psychotic disorder 32.0 TPH1 SLC6A4 HTR2A HTR1A DRD4 BDNF
19 fibromyalgia 32.0 SLC6A4 HTR2A CRH
20 social phobia 32.0 SLC6A4 HTR1A
21 eating disorder 31.9 SLC6A4 CRH BDNF
22 postpartum depression 31.9 SLC6A4 CRH BDNF
23 attention deficit-hyperactivity disorder 31.9 TPH2 TPH1 SLC6A4 HTR2A HTR1A DRD4
24 bipolar disorder 31.9 TPH1 SLC6A4 HTR2A HTR1A DISC2 BDNF
25 tobacco addiction 31.8 TPH1 SLC6A4 HTR2A
26 conduct disorder 31.8 TPH1 SLC6A4 DRD4
27 substance dependence 31.8 SLC6A4 DRD4 BDNF
28 anorexia nervosa 31.7 SLC6A4 HTR2A CRH BDNF
29 chronic fatigue syndrome 31.7 TPH2 SLC6A4 HTR2A HTR1A CRH
30 bulimia nervosa 31.7 SLC6A4 HTR2A BDNF
31 paranoid schizophrenia 31.6 TPH2 SLC6A4 HTR2A BDNF
32 drug dependence 31.6 SLC6A4 CRH CHRM2 BDNF
33 disease of mental health 31.6 SLC6A4 HTR2A HTR1A DRD4 CRH BDNF
34 irritable bowel syndrome 31.6 TPH1 SLC6A4 CRH
35 oppositional defiant disorder 31.5 TPH2 SLC6A4 DRD4
36 parkinson disease, late-onset 31.5 SLC6A4 HTR2A HTR1A BDNF APOE
37 mood disorder 31.5 TPH2 TPH1 SLC6A4 HTR2A HTR1A DRD4
38 autism 31.5 SLC6A4 HTR2A HTR1A BDNF
39 serotonin syndrome 31.4 SLC6A4 HTR2A HTR1A
40 migraine without aura 31.2 SLC6A4 HTR1A DRD4
41 tic disorder 31.1 TPH2 HTR2A DRD4
42 pathological gambling 31.1 SLC6A4 HTR2A DRD4
43 hypoactive sexual desire disorder 31.0 HTR2A HTR1A
44 schizophrenia 5 30.9 HTR2A HTR1A
45 phobic disorder 30.9 SLC6A4 HTR1A
46 schizophrenia 30.8 TPH2 TPH1 SLC6A4 HTR2A HTR1A DRD4
47 kleptomania 30.8 SLC6A4 HTR1A
48 schizoaffective disorder 30.6 SLC6A4 HTR2A DISC2 BDNF
49 heroin dependence 30.5 DRD4 BDNF
50 autism spectrum disorder 30.2 TPH2 SLC6A4 HTR2A DISC2 BDNF

Comorbidity relations with Major Depressive Disorder via Phenotypic Disease Network (PDN): (show top 50) (show all 52)

Acute Cystitis Adjustment Disorder
Alzheimer Disease Anorexia Nervosa
Anxiety Atypical Depressive Disorder
Avoidant Personality Disorder Bipolar Disorder
Borderline Personality Disorder Bronchitis
Cerebral Atherosclerosis Cerebral Degeneration
Conversion Disorder Decubitus Ulcer
Deficiency Anemia Delusional Disorder
Dependent Personality Disorder Dysthymic Disorder
Eating Disorder Esophagitis
Generalized Anxiety Disorder Heart Disease
Histrionic Personality Disorder Hypertension, Essential
Hypochondriasis Hypothyroidism
Iron Deficiency Anemia Irritable Bowel Syndrome
Major Affective Disorder 9 Mitral Valve Disease
Mood Disorder Narcissistic Personality Disorder
Obsessive-Compulsive Disorder Obsessive-Compulsive Personality Disorder
Opioid Addiction Osteoarthritis
Osteoporosis Paralytic Ileus
Paranoid Personality Disorder Paranoid Schizophrenia
Parkinson Disease, Late-Onset Personality Disorder
Post-Traumatic Stress Disorder Protein-Energy Malnutrition
Respiratory Failure Schizoid Personality Disorder
Schizophrenia Schizophreniform Disorder
Somatization Disorder Swallowing Disorders

Graphical network of the top 20 diseases related to Major Depressive Disorder:

Diseases related to Major Depressive Disorder

Symptoms & Phenotypes for Major Depressive Disorder

Clinical features from OMIM:


UMLS symptoms related to Major Depressive Disorder:

mental and behavioral signs and symptoms, depressive symptoms

MGI Mouse Phenotypes related to Major Depressive Disorder:

# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.4 APOE BDNF CHRM2 CRH DRD4 FKBP5

Drugs & Therapeutics for Major Depressive Disorder

Drugs for Major Depressive Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 553)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Etomidate Approved Phase 4 33125-97-2 36339 667484
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
Reboxetine Approved, Experimental Phase 4 98769-81-4, 71620-89-8 123628 65856
Ropinirole Approved, Investigational Phase 4 91374-21-9, 91374-20-8 5095 497540
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
Ziprasidone Approved Phase 4 146939-27-7 60854
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
Brexpiprazole Approved, Investigational Phase 4 913611-97-9 11978813
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
Amitriptyline Approved Phase 4 50-48-6 2160
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
Selegiline Approved, Investigational, Vet_approved Phase 4 14611-51-9 5195 26757
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
Pindolol Approved, Investigational Phase 4 13523-86-9 4828
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
Racepinephrine Approved Phase 4 329-65-7 838
Testosterone Approved, Experimental, Investigational Phase 4 481-30-1, 58-22-0 6013 10204
Propranolol Approved, Investigational Phase 4 525-66-6 4946
Imipramine Approved Phase 4 50-49-7 3696
Memantine Approved, Investigational Phase 4 19982-08-2 4054
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
Nortriptyline Approved Phase 4 72-69-5 4543
Moclobemide Approved, Investigational Phase 4 71320-77-9 4235
Desipramine Approved, Investigational Phase 4 50-47-5 2995
Curcumin Approved, Experimental, Investigational Phase 4 458-37-7 969516
Iloperidone Approved Phase 4 133454-47-4 71360
Asenapine Approved Phase 4 65576-45-6, 85650-56-2 3001386
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
Testosterone enanthate Approved Phase 4 315-37-7 9416
Methyltestosterone Approved Phase 4 58-18-4 6010
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
Acamprosate Approved, Investigational Phase 4 77337-76-9 71158
Methohexital Approved Phase 4 151-83-7 9034
Ondansetron Approved Phase 4 99614-02-5 4595
Metformin Approved Phase 4 657-24-9 4091 14219
Maprotiline Approved, Investigational Phase 4 10262-69-8 4011
Protriptyline Approved Phase 4 438-60-8 4976
Topiramate Approved Phase 4 97240-79-4 5284627
Trimipramine Approved Phase 4 739-71-9 5584 4055
Isocarboxazid Approved Phase 4 59-63-2 3759
Doxepin Approved, Investigational Phase 4 1668-19-5 667477 667468
Zolpidem Approved Phase 4 82626-48-0 5732
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
Alendronate Approved Phase 4 66376-36-1, 121268-17-5 2088

Interventional clinical trials:

(show top 50) (show all 2427)
# Name Status NCT ID Phase Drugs
1 Phase 4 Study of Escitalopram Treatment and Biomarkers in Major Depressive Disorder Unknown status NCT01997580 Phase 4 escitalopram
2 Role of Inflammation Factors and Insulin Resistance in the Pathophysiology and Treatment Response of Major Depressive Disorder Unknown status NCT01699490 Phase 4 Fluoxetine + Valsartan;Fluoxetine + Placebo
3 The Effect and Reliability of Escitalopram in the Treatment of Adolescents With Major Depressive Disorder or Anxiety Disorders Unknown status NCT03122158 Phase 4 Escitalopram
4 Vortioxetine Versus Placebo in Major Depressive Disorder Comorbid With Social Anxiety Disorder Unknown status NCT02294305 Phase 4 Vortioxetine;Placebo
5 Pharmacogenomics Studies of Antidepressants Unknown status NCT01204086 Phase 4 Venlafaxine;Fluoxetine
6 Beta-arrestins and Response to Venlafaxine in Major Depressive Disorder Unknown status NCT02051413 Phase 4 Venlafaxine extended release
7 THE AIUNI - Integral Assessment in Unipolar Depression Unknown status NCT02268487 Phase 4 Sertraline
8 Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive Disorder Unknown status NCT01460212 Phase 4 SSRI antidepressants
9 Randomized,Controlled and Open-label Study of Buspirone add-on Treatment in Patients With Major Depression Disorder Unknown status NCT02273154 Phase 4 Buspirone;Paroxetine
10 Exploring Alterations of Central Autonomic Modulation in Patients With Bipolar Depression Unknown status NCT01213121 Phase 4 Quetiapine
11 Effect of Escitalopram vs. Reboxetine on Somatic and Visceral Sensitivity of Patients With Major Depressive Disorder: a Randomized, Double Blind Clinical Trial Unknown status NCT00209807 Phase 4 escitalopram;Reboxetine
12 Escitalopram and Sleep Architecture in Patients With Major Depressive Disorder Unknown status NCT00442481 Phase 4 Escitalopram
13 Hyperventilation and ECT Seizure Duration: Effects on Cerebral Oxygen Saturation, and Therapeutic Outcome With Comparisons Between Etomidate and Ketamine in Patients With Major Depressive Disorder Unknown status NCT02924090 Phase 4 Etomidate;Ketamine
14 Duloxetine for the Treatment of Major Depression in Midlife Women: Effects on Brain Structure and Functioning, Mood, and Quality of Life Unknown status NCT00889369 Phase 4 Duloxetine
15 A Randomised Trial Investigating the Cardiovascular Effects of Agomelatine and Escitalopram in Patients With Major Depressive Disorder. Unknown status NCT01483053 Phase 4 Agomelatine;Escitalopram
16 Algorithm Guided Treatment Strategies for Major Depressive Disorder Unknown status NCT01764867 Phase 4 Escitalopram;Mirtazapine;Fluoxetine;Citalopram;Escitalopram;Paroxetine;Sertraline;Fluvoxamine;Venlafaxine;Duloxetine;Mirtazapine;Bupropion;Trazodone
17 Evaluation of the Efficacy of Repetitive Transcranial Magnetic Stimulation on Cognitive, Anxiety and Depressive Symptoms in Patients Diagnosed With Major Depressive Disorder Unknown status NCT02213016 Phase 4
18 A Randomized Controlled Study Comparing Fluoxetine With Bupropion for Impulsivity and Suicidality in Patients With Major Depressive Disorder and Comorbid Alcoholism (Abuse or Dependence) Unknown status NCT00449007 Phase 4 fluoxetine;bupropion
19 The Effect of Quetiapine XR in Depressive Patients Showing Aberrant N100 Amplitude Slope Unknown status NCT01357967 Phase 4 SSRI monotherapy;Seroquel XR adjunctive
20 Brain Mechanisms and Targeting Insomnia in Major Depression Unknown status NCT00628914 Phase 4 escitalopram and eszopiclone;Escitalopram, eszopiclone, and placebo;Escitalopram
21 A Controlled Study of the Efficacy of Botulinum Toxin A (Botox) for the Treatment of Major Depressive Disorder (MDD) Unknown status NCT01556971 Phase 4 Botox;Saline Solution
22 Prediction of Individual Treatment Response Based on Brain Changes at the Early Phase of Antidepressant Treatment in Major Depressive Disorder Using Machine Learning Classification Analysis Unknown status NCT02330679 Phase 4 Desvenlafaxine;Placebo
23 Dose Response Effects of Estrogen Augmentation in Mood & Memory in Perimenopausal Depression Unknown status NCT00229450 Phase 4 estrogen
24 Phase 4 Study on the Effect of Partial Sleep Deprivation on Cognition and the IL-6-gp130-System in Individuals With Major Depression Unknown status NCT00291239 Phase 4
25 Inflammatory Markers and Cognitive Function in Major Depression:a Pilot Study Unknown status NCT01391221 Phase 4 Duloxetine
26 Optimizing Antidepressant Treatment by Genotype-dependent Adjustment of Medication According to the ABCB1 Gene Unknown status NCT02237937 Phase 4 Paroxetine;Sertraline;Citalopram;Venlafaxine;Amitriptyline;Escitalopram;Amitriptylinoxide;Nortriptyline;Trimipramine
27 White Matter Structure and Response to Treatment With Antidepressants: a Study of Desvenlafaxine in Major Depression. A Pilot Study Unknown status NCT01492621 Phase 4 Desvenlafaxine
28 Escitalopram Treatment of Major Depression in Diabetes Mellitus: An Open Label Unknown status NCT00650897 Phase 4 Escitalopram
29 A Placebo Controlled Trial of the Dopamine D-2 Receptor Agonist Ropinirole in Treatment of 60 Patients With Refractory Bipolar I and II Depression. Unknown status NCT00335205 Phase 4 ropinirole
30 A Double-Blind, Placebo-Controlled, Enriched Enrollment Randomized Withdrawal Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
31 Neurochemical,Metabonomics and Neuroimaging Characterization of TCM Diagnostic Subtypes of Major Depression Disorder Unknown status NCT02346682 Phase 4 venlafaxine
32 Phase 4 Study of Vitamin D3 Supplementation for Outcomes in Patients With Unipolar Depression Unknown status NCT01390662 Phase 4
33 Phase 3 Reboxetine Treatment in Depressed Children and Adolescents an 8-Week, Open Study Unknown status NCT00426946 Phase 4 Reboxetine
34 Prospective 24-week Study, Comparing Clinical Outcomes Between Switching Antidepressants and Maintaining the Same Antidepressant in Patients With Major Depressive Disorder Who do Not Show a 20% Reduction in Symptoms at Week 2 Unknown status NCT00519012 Phase 4 Sertraline to Paroxetine;Paroxetine to Sertraline
35 Phase 4 Study of Clinical Pharmacogenomics of Antidepressant Response Unknown status NCT00269334 Phase 4 Using Citalopram(drug) or Paroxetine(drug)
36 Advancing Personalized Antidepressant Treatment Using PET/MRI Unknown status NCT02623205 Phase 4 Escitalopram;Placebo
37 Predictors of Response to Augmentation With Ziprasidone (Geodon®) in Major Depressive Disorder : A 13-week, Double-Blind, Placebo-Controlled, Cross-Over Trial Completed NCT01168674 Phase 4 ziprasidone;Sugar pill
38 Randomized Placebo-Controlled Trial of Ramelteon in the Treatment of Sleep and Mood in Patients With Seasonal Affective Disorder Completed NCT00502320 Phase 4 Ramelteon;Placebo
39 A Double-blind, Placebo-controlled, Fixed-dose Study of Vilazodone in Patients With Major Depressive Disorder Completed NCT01473394 Phase 4 Dose-matched placebo;Vilazodone
40 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Relapse Prevention Study With Vilazodone in Patients With Major Depressive Disorder Completed NCT01573598 Phase 4 Placebo;Vilazodone;Vilazodone
41 Lilly's Emotional and Physical Symptoms of Depression Study Completed NCT00479726 Phase 4 duloxetine hydrochloride
42 An Open Label Study Assessing Paxil CR (Paroxetine CR) in Patients With Major Depressive Disorder Who Discontinued Treatment With Selective Serotonin Reuptake Inhibitors or a Selective Serotonin/Norepinephrine Reuptake Inhibitor Due to Intolerability Completed NCT00049972 Phase 4 paroxetine CR
43 A Double-blind, Placebo- and Active-controlled, Fixed-dose Study of Vilazodone in Patients With Major Depressive Disorder Completed NCT01473381 Phase 4 Vilazodone;Placebo to citalopram;Placebo to vilazodone;Citalopram
44 An Open-label Long-term Study of Escitalopram in Children 7 to 11 Years of Age With Major Depressive Disorder Completed NCT01198795 Phase 4 Escitalopram
45 A Multicenter, Randomized, Double-blind, Placebo-Controlled, Relapse-Prevention Study With Levomilnacipran ER in Patients With Major Depressive Disorder Completed NCT02288325 Phase 4 Levomilnacipran ER;Placebo
46 Aripiprazole for the Augmentation of Antidepressant Therapy: An Observational, Outpatients Study in Inadequate Responders Diagnosed With Major Depressive Disorder Completed NCT01429831 Phase 4 Aripiprazole
47 A Multicenter, Parallel-Group, Randomized, 10-Week, Double-Blind, Placebo-Controlled Study To Evaluate The Efficacy And Safety Of 50 mg Of DVS SR In The Treatment Of Peri- And Postmenopausal Women With Major Depressive Disorder Completed NCT01121484 Phase 4 desvenlafaxine succinate sustained-release;placebo
48 A Phase 4 Comparison of Duloxetine Dosing Strategies in the Treatment of Korean Patients With Major Depressive Disorder Completed NCT00960986 Phase 4 Duloxetine hydrochloride
49 An Open-Label, 8-week Trial of Bupropion Hydrochloride Extended Release (Wellbutrin XL®) In Patients With Major Depressive Disorder (MDD) With Atypical Features. Completed NCT01477931 Phase 4 Bupropion extended release
50 A Phase IV, Double-Blind, Placebo-Controlled, Randomized, Flexible Dose Study of the Safety and Efficacy of EMSAM in Adolescents With Major Depression Completed NCT00531947 Phase 4 Selegiline Transdermal System;Placebo

Search NIH Clinical Center for Major Depressive Disorder

Inferred drug relations via UMLS 72 / NDF-RT 51 :

St. John's Wort

Cochrane evidence based reviews: seasonal affective disorder

Genetic Tests for Major Depressive Disorder

Genetic tests related to Major Depressive Disorder:

# Genetic test Affiliating Genes
1 Major Depressive Disorder 29 FKBP5 HTR2A TPH2

Anatomical Context for Major Depressive Disorder

MalaCards organs/tissues related to Major Depressive Disorder:

Brain, Testes, Cortex, Heart, Prefrontal Cortex, Amygdala, Pituitary

Publications for Major Depressive Disorder

Articles related to Major Depressive Disorder:

(show top 50) (show all 22219)
# Title Authors PMID Year
Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment. 38 8 71
16642436 2006
Lack of association of TPH2 exon XI polymorphisms with major depression and treatment resistance. 8 71
16027738 2005
Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. 8 71
15629698 2005
A negative regulator of MAP kinase causes depressive behavior. 38 8
20953200 2010
Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder. 38 8
19181679 2009
The breakpoint cluster region gene on chromosome 22q11 is associated with bipolar disorder. 38 8
15866548 2005
The power of sample size and homogenous sampling: association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorder. 38 8
15691525 2005
Increased risk for recurrent major depression in DYT1 dystonia mutation carriers. 38 8
15326234 2004
Genome-wide linkage survey for genetic loci that influence the development of depressive disorders in families with recurrent, early-onset, major depression. 38 8
14582139 2003
A polymorphism (5-HTTLPR) in the serotonin transporter promoter gene is associated with DSM-IV depression subtypes in seasonal affective disorder. 38 8
14593433 2003
The association of the D2S2944 124 bp allele with recurrent early onset major depressive disorder in women. 38 8
12898573 2003
Sequence variations in CREB1 cosegregate with depressive disorders in women. 38 8
12851637 2003
Genetics of recurrent early-onset depression (GenRED): design and preliminary clinical characteristics of a repository sample for genetic linkage studies. 38 8
12707949 2003
Genetic linkage of region containing the CREB1 gene to depressive disorders in women from families with recurrent, early-onset, major depression. 38 8
12457397 2002
Genome survey for susceptibility loci for recurrent, early-onset major depression: results at 10cM resolution. 38 8
11992563 2002
D2S2944 identifies a likely susceptibility locus for recurrent, early-onset, major depression in women. 38 8
12082563 2002
Malignancy of recurrent, early-onset major depression: a family study. 38 8
11803516 2001
Major depressive disorder in a community-based twin sample: are there different genetic and environmental contributions for men and women? 38 8
10359473 1999
A hospital-based twin register of the heritability of DSM-IV unipolar depression. 38 8
8629888 1996
Increased concentration of calcitonin gene-related peptide in cerebrospinal fluid of depressed patients. A possible trait marker of major depressive disorder. 38 8
7715797 1994
Second-generation antidepressants for preventing seasonal affective disorder in adults. 38 17
30883669 2019
Light therapy for preventing seasonal affective disorder. 38 17
30883670 2019
Tanning dependence and seasonal affective disorder are frequent among sunbathers but are not associated. 38 17
30605797 2019
Shared genetic factors in migraine and depression: evidence from a genetic isolate. 8
20071666 2010
Born to be happy? The etiology of subjective well-being. 8
19728071 2009
Genetic and environmental influences on optimism and its relationship to mental and self-rated health: a study of aging twins. 8
19618259 2009
Functional properties of missense variants of human tryptophan hydroxylase 2. 71
19319927 2009
Cortical thinning in persons at increased familial risk for major depression. 8
19329490 2009
Molecular genetics of bipolar disorder and depression. 8
17239033 2007
The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis. 8
16402130 2006
Haplotype analysis reveals tryptophan hydroxylase (TPH) 1 gene variants associated with major depression. 8
16165107 2006
Two different putative genetic animal models of childhood depression. 8
16095569 2006
Familial clustering of major depression and anxiety disorders in Australian and Dutch twins and siblings. 8
16354503 2005
Association study of CREB1 and childhood-onset mood disorders. 8
15999345 2005
Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depression. 8
15867107 2005
The dopamine D4 receptor gene 48-base-pair-repeat polymorphism and mood disorders: a meta-analysis. 8
15860340 2005
Association analysis of monoamine genes with measures of depression and anxiety in a selected community sample of siblings. 8
15729745 2005
Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. 8
15565110 2004
Genome-wide linkage analysis of a composite index of neuroticism and mood-related scales in extreme selected sibships. 8
15351774 2004
Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome. 8
15229186 2004
Can "blue" genes affect mood and movement? 8
15326229 2004
Untreated depression and hippocampal volume loss. 8
12900317 2003
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. 8
12869766 2003
Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study. 8
12796225 2003
Genetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes? 8
11352363 2001
Genetic epidemiology of major depression: review and meta-analysis. 8
11007705 2000
Genetic segregation analysis of early-onset recurrent unipolar depression. 8
9399885 1997
Evidence-based health policy--lessons from the Global Burden of Disease Study. 8
8966556 1996
Polymorphism in serotonin transporter gene associated with susceptibility to major depression. 8
8602004 1996
The lifetime history of major depression in women. Reliability of diagnosis and heritability. 8
8215812 1993

Variations for Major Depressive Disorder

ClinVar genetic disease variations for Major Depressive Disorder:

# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 TPH2 NM_173353.4(TPH2): c.1322G> A (p.Arg441His) single nucleotide variant risk factor rs120074175 12:72425324-72425324 12:72031544-72031544
2 HTR2A NM_000621.4(HTR2A): c.614-2211T> C single nucleotide variant drug response rs7997012 13:47411985-47411985 13:46837850-46837850
3 APOE NM_000041.4(APOE): c.364C> A (p.Leu122Met) single nucleotide variant not provided rs587778876 19:45411917-45411917 19:44908660-44908660
4 APOE NM_000041.4(APOE): c.451C> A (p.Leu151Met) single nucleotide variant not provided rs587778877 19:45412004-45412004 19:44908747-44908747

Expression for Major Depressive Disorder

Search GEO for disease gene expression data for Major Depressive Disorder.

Pathways for Major Depressive Disorder

Pathways related to Major Depressive Disorder according to KEGG:

# Name Kegg Source Accession
1 Serotonergic synapse hsa04726

GO Terms for Major Depressive Disorder

Cellular components related to Major Depressive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutamatergic synapse GO:0098978 9.56 HTR2A DRD4 CHRM2 APOE
2 integral component of presynaptic membrane GO:0099056 9.33 SLC6A4 HTR2A CHRM2
3 integral component of postsynaptic membrane GO:0099055 9.13 SLC6A4 HTR2A CHRM2
4 dendrite GO:0030425 9.1 HTR2A HTR1A DRD4 CHRM2 BDNF APOE

Biological processes related to Major Depressive Disorder according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cellular calcium ion homeostasis GO:0006874 9.7 HTR2A DRD4 APOE
2 circadian rhythm GO:0007623 9.67 TPH2 TPH1 SLC6A4
3 memory GO:0007613 9.65 SLC6A4 HTR2A BDNF
4 chemical synaptic transmission GO:0007268 9.65 HTR2A HTR1A DRD4 CRH CHRM2
5 response to immobilization stress GO:0035902 9.57 TPH1 CRH
6 positive regulation of kinase activity GO:0033674 9.56 HTR2A DRD4
7 behavioral response to cocaine GO:0048148 9.55 HTR2A DRD4
8 vasoconstriction GO:0042310 9.54 SLC6A4 HTR1A
9 locomotory exploration behavior GO:0035641 9.51 CRH APOE
10 regulation of dopamine metabolic process GO:0042053 9.46 HTR1A DRD4
11 serotonin receptor signaling pathway GO:0007210 9.43 HTR2A HTR1A
12 behavior GO:0007610 9.4 HTR2A HTR1A
13 aromatic amino acid family metabolic process GO:0009072 9.37 TPH2 TPH1
14 serotonin biosynthetic process GO:0042427 9.32 TPH2 TPH1
15 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.26 HTR2A HTR1A DRD4 CHRM2
16 regulation of serotonin secretion GO:0014062 9.16 HTR1A CRH
17 G protein-coupled serotonin receptor signaling pathway GO:0098664 8.92 HTR2A HTR1A DRD4 CHRM2
18 G protein-coupled receptor signaling pathway GO:0007186 10.05 HTR2A HTR1A DRD4 CRH CHRM2 APOE

Molecular functions related to Major Depressive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.37 HTR2A DRD4
2 serotonin binding GO:0051378 9.33 SLC6A4 HTR2A HTR1A
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen GO:0016714 9.32 TPH2 TPH1
4 tryptophan 5-monooxygenase activity GO:0004510 9.26 TPH2 TPH1
5 neurotransmitter receptor activity GO:0030594 9.26 HTR2A HTR1A DRD4 CHRM2
6 G protein-coupled serotonin receptor activity GO:0004993 8.92 HTR2A HTR1A DRD4 CHRM2

Sources for Major Depressive Disorder

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
71 Tocris
73 UMLS via Orphanet
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