MCID: MLK004
MIFTS: 33

Malakoplakia

Categories: Gastrointestinal diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Malakoplakia

MalaCards integrated aliases for Malakoplakia:

Name: Malakoplakia 52 58
Malacoplakia 52 17 71

Characteristics:

Orphanet epidemiological data:

58
malakoplakia
Age of onset: Adult; Age of death: adult;

Classifications:

Orphanet: 58  
Rare gastroenterological diseases


Summaries for Malakoplakia

NIH Rare Diseases : 52 Malakoplakia is a rare chronic inflammatory disease. It most commonly involves the urogenital system (reproductive organs and urinary system), but may also be found in other regions of the body, including the pelvis, bones, lungs, thyroid gland , gastrointestinal (digestive) tract, skin, and kidneys. Symptoms of malakoplakia differ depending on the involved area. For example, when the skin is affected the malakoplakia may appear rash-like with small areas of itchy, reddened skin that may be painful and/or fluid filled. The cause of malakoplakia is not well understood. It is thought to be related to an issue with the function of one's macrophages, which are one type of cell within the immune system that respond to foreign invaders (bacteria ). E.coli is the most common type of bacteria that leads to malakoplakia. Individuals with a compromised immune system have an elevated risk to develop malakoplakia. Treatment typically begins with antibiotics .

MalaCards based summary : Malakoplakia, also known as malacoplakia, is related to prostatic malacoplakia associated with prostatic abscess and colonic malakoplakia, and has symptoms including muscle weakness and polydipsia. Affiliated tissues include prostate, kidney and colon, and related phenotypes are proteinuria and fever

Wikipedia : 74 Malakoplakia (from Greek Malako "soft" + Plako "plaque") is a rare inflammatory condition which makes... more...

Related Diseases for Malakoplakia

Diseases related to Malakoplakia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 204)
# Related Disease Score Top Affiliating Genes
1 prostatic malacoplakia associated with prostatic abscess 12.4
2 colonic malakoplakia 12.4
3 acute cystitis 10.5
4 pyelonephritis 10.4
5 xanthogranulomatous pyelonephritis 10.4
6 adenocarcinoma 10.4
7 kidney disease 10.4
8 immune deficiency disease 10.3
9 cystitis 10.3
10 chronic granulomatous disease 10.3
11 acquired immunodeficiency syndrome 10.3
12 interstitial nephritis 10.2
13 megalocytic interstitial nephritis 10.2
14 renal cell carcinoma, nonpapillary 10.2
15 sarcoidosis 1 10.2
16 agammaglobulinemia 10.2
17 acute kidney failure 10.2
18 hydronephrosis 10.1
19 diarrhea 10.1
20 adenoma 10.1
21 end stage renal failure 10.1
22 herpes simplex 10.1
23 ulcerative colitis 10.1
24 neonatal herpes 10.1
25 prostate cancer 10.1
26 human immunodeficiency virus type 1 10.1
27 colorectal adenocarcinoma 10.1
28 colitis 10.1
29 bacterial infectious disease 10.1
30 urinary tract obstruction 10.1
31 suppressor of tumorigenicity 3 10.0
32 vesicoureteral reflux 1 10.0
33 suppression of tumorigenicity 12 10.0
34 obstructive nephropathy 10.0
35 protein-losing enteropathy 10.0
36 uremia 10.0
37 epididymo-orchitis 10.0
38 adrenogenital syndrome 10.0
39 autoimmune disease 10.0
40 systemic lupus erythematosus 10.0
41 lymphoma, hodgkin, classic 10.0
42 inflammatory bowel disease 10.0
43 diffuse large b-cell lymphoma 10.0
44 villous adenoma 10.0
45 nephrosclerosis 10.0
46 neutropenia 10.0
47 pancytopenia 10.0
48 klebsiella pneumonia 10.0
49 pyuria 10.0
50 prostatitis 10.0

Graphical network of the top 20 diseases related to Malakoplakia:



Diseases related to Malakoplakia

Symptoms & Phenotypes for Malakoplakia

Human phenotypes related to Malakoplakia:

58 31 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 proteinuria 58 31 hallmark (90%) Very frequent (99-80%) HP:0000093
2 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
3 subcutaneous nodule 58 31 hallmark (90%) Very frequent (99-80%) HP:0001482
4 abnormal bleeding 58 31 hallmark (90%) Very frequent (99-80%) HP:0001892
5 abdominal pain 58 31 hallmark (90%) Very frequent (99-80%) HP:0002027
6 pruritus 58 31 hallmark (90%) Very frequent (99-80%) HP:0000989
7 skin rash 58 31 hallmark (90%) Very frequent (99-80%) HP:0000988
8 papule 58 31 hallmark (90%) Very frequent (99-80%) HP:0200034
9 skin ulcer 58 31 hallmark (90%) Very frequent (99-80%) HP:0200042
10 hematuria 58 31 hallmark (90%) Very frequent (99-80%) HP:0000790
11 diarrhea 58 31 hallmark (90%) Very frequent (99-80%) HP:0002014
12 abnormality of the menstrual cycle 58 31 hallmark (90%) Very frequent (99-80%) HP:0000140
13 urinary urgency 58 31 hallmark (90%) Very frequent (99-80%) HP:0000012
14 dysuria 58 31 hallmark (90%) Very frequent (99-80%) HP:0100518
15 urinary hesitancy 58 31 hallmark (90%) Very frequent (99-80%) HP:0000019
16 urinary bladder inflammation 58 31 hallmark (90%) Very frequent (99-80%) HP:0100577
17 immunodeficiency 58 31 frequent (33%) Frequent (79-30%) HP:0002721
18 follicular hyperplasia 58 31 frequent (33%) Frequent (79-30%) HP:0002729
19 cough 58 31 occasional (7.5%) Occasional (29-5%) HP:0012735
20 chest pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0100749
21 abnormality of the neck 58 31 occasional (7.5%) Occasional (29-5%) HP:0000464
22 neoplasm of the colon 58 31 occasional (7.5%) Occasional (29-5%) HP:0100273
23 neoplasm of the rectum 58 31 occasional (7.5%) Occasional (29-5%) HP:0100743
24 abnormality of the tongue 58 31 occasional (7.5%) Occasional (29-5%) HP:0000157
25 orchitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100796
26 prostate neoplasm 58 31 occasional (7.5%) Occasional (29-5%) HP:0100787
27 inflammatory abnormality of the skin 58 Very frequent (99-80%)

UMLS symptoms related to Malakoplakia:


muscle weakness, polydipsia

Drugs & Therapeutics for Malakoplakia

Search Clinical Trials , NIH Clinical Center for Malakoplakia

Genetic Tests for Malakoplakia

Anatomical Context for Malakoplakia

MalaCards organs/tissues related to Malakoplakia:

40
Prostate, Kidney, Colon, Skin, Lung, Thyroid, Bone

Publications for Malakoplakia

Articles related to Malakoplakia:

(show top 50) (show all 1014)
# Title Authors PMID Year
1
Ultrastructural evidence of the evolutional process in malakoplakia. 61
31298302 2020
2
[Penile malakoplakia associated with lichen sclerosus]. 61
31627929 2019
3
Bilateral Ovarian Malacoplakia: Case Report and Review of the Literature With Clinical and Diagnostic Considerations. 61
31851062 2019
4
Bladder Malakoplakia Simulating Neoplasm in a Young Girl: Report of a Case and Review of Literature. 61
30596224 2019
5
Imaging Manifestations of Acute and Chronic Renal Infection That Mimics Malignancy: How to Make the Diagnosis Using Computed Tomography and Magnetic Resonance Imaging. 61
31537315 2019
6
Cecal Malakoplakia - an Unusual Cause of Anemia in Liver Cirrhosis. 61
31517320 2019
7
Malakoplakia of the Bladder in a 4-Month-Old Puppy. 61
31433228 2019
8
von Hansemann Cells from Fresh Urine Sediment Samples in the Diagnosis of Malakoplakia. 61
31359917 2019
9
Malakoplakia of the Urinary Bladder and Unilateral Ureter. 61
31133162 2019
10
Malacoplakia of the skin: overview of a rare clinical entity. 61
31329385 2019
11
Malakoplakia of the parotid gland: a case report and review of localised malakoplakia of the head and neck. 61
30855168 2019
12
Cutaneous malakoplakia presenting as a groin swelling and graft failure. 61
31015237 2019
13
Malakoplakia in Thoracic Transplant Recipients. 61
30979478 2019
14
Malakoplakia of the colon following renal transplantation in a 73 year old woman: report of a case presenting as intestinal perforation. 61
30866984 2019
15
Fetal cerebral malakoplakia associated with recurrent facial erysipelas of the mother. 61
30563611 2019
16
Cutaneous Malakoplakia. 61
30726684 2019
17
Pulmonary malakoplakia secondary to Rhodococcus equi infection mimicking a lung neoplasm in a lung transplant recipient. 61
30063120 2019
18
Malakoplakia in Association with Adenocarcinoma of Sigmoid Colon; A Case Report. 61
31583004 2019
19
Malakoplakia of the urinary system. 61
31659350 2019
20
Chronic Diarrhea Related to Colonic Malakoplakia Successfully Treated with Budesonide in a Kidney Transplant Recipient. 61
30356178 2018
21
Malakoplakia complicating cutaneous septic vasculitis in an immunosuppressed liver transplant patient. 61
30530424 2018
22
Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders. 61
30366790 2018
23
An Unusual Association of Renal Cell Carcinoma and Renal Malakoplakia with Focal Segmental Glomerulosclerosis in an Elderly Patient. 61
30647507 2018
24
A case of primary cutaneous malakoplakia in a cardiac transplant recipient. 61
30406173 2018
25
Multiple extensive malacoplakia mimicking metastatic carcinoma. 61
29417571 2018
26
Malakoplakia as a cause of severe hypercalcemia through ectopic 25-hydroxyvitamin D3 1-alpha-hydroxylase expression: A case report. 61
30290590 2018
27
Colorectal malakoplakia in a patient with hypogammaglobulinemia. 61
29627491 2018
28
A novel cause of postmenopausal bleeding in an immunosuppressed patient. 61
29991552 2018
29
Case - Malakoplakia in a 58-year-old male following living donor renal transplantation. 61
30059290 2018
30
Malakoplakia of the prostate diagnosed on multiparametric-MRI ultrasound fusion guided biopsy: A case report and review of the literature. 61
29785385 2018
31
Colonic Malakoplakia: A Rare Finding in a Healthy Male. 61
30186099 2018
32
Fluorodeoxyglucose avid malakoplakia of the laryngohypopharynx masquerading as malignant tumor: A pathological enigma and clinical dilemma. 61
29676386 2018
33
Renal malakoplakia mimicking a locally advanced renal mass: A case report. 61
29541596 2018
34
Phenotypic appearances of prostate utilizing PET-MRI and PET-CT with 68Ga-PSMA, radiolabelled choline and 68Ga-DOTATATE. 61
29384832 2018
35
Malakoplakia of the large intestine: an incidental extremely rare finding. 61
29694309 2018
36
Bilateral hydroureteronephrosis with renal failure caused by malacoplakia. 61
28967059 2018
37
No significant risk of secondary prostatic cancer in a patient with prostatic malakoplakia after a four-year follow-up. 61
31949808 2018
38
Bladder Malakoplakia in Systemic Sclerosis Patient: A Case Report and Review Literature. 61
29967807 2018
39
Malakoplakia after kidney transplantation: Case report and literature review. 61
28561517 2017
40
Cutaneous malakoplakia: Interesting case report and review of literature. 61
28749381 2017
41
Cutaneous malakoplakia masquerading as pyoderma gangrenosum. 61
27524799 2017
42
Malakoplakia Presenting as an Endobronchial Lesion in a Human Immunodeficiency Virus-Positive Man. 61
28864380 2017
43
Granulomatous & histiocytic dermatitides. 61
28094163 2017
44
Rectosigmoid malakoplakia. 61
28566412 2017
45
Malacoplakia mimicking colonic malignancy: A case report. 61
29446821 2017
46
Malakoplakia of the Prostate as a Mimicker of Prostate Cancer on Prostate Health Index and Magnetic Resonance Imaging-Fusion Prostate Biopsy: A Case Report. 61
28736746 2017
47
A case of gallbladder mass: Malakoplakia (The tumor mimicker). 61
28195110 2017
48
Nonhealing surgical wound due to cutaneous malakoplakia. 61
27935636 2017
49
Enteral Malakoplakia Prior to Helicobacter cinaedi Bacteremia. 61
28050043 2017
50
Complicated Genitourinary Tract Infections and Mimics. 61
26995297 2017

Variations for Malakoplakia

Expression for Malakoplakia

Search GEO for disease gene expression data for Malakoplakia.

Pathways for Malakoplakia

GO Terms for Malakoplakia

Sources for Malakoplakia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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