MCID: MLK004
MIFTS: 33

Malakoplakia

Categories: Gastrointestinal diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Malakoplakia

MalaCards integrated aliases for Malakoplakia:

Name: Malakoplakia 52 58
Malacoplakia 52 17 71

Characteristics:

Orphanet epidemiological data:

58
malakoplakia
Age of onset: Adult; Age of death: adult;

Classifications:

Orphanet: 58  
Rare gastroenterological diseases


Summaries for Malakoplakia

NIH Rare Diseases : 52 Malakoplakia is a rare chronic inflammatory disease. It most commonly involves the urogenital system (reproductive organs and urinary system), but may also be found in other regions of the body, including the pelvis, bones, lungs, thyroid gland , gastrointestinal (digestive) tract, skin, and kidneys. Symptoms of malakoplakia differ depending on the involved area. For example, when the skin is affected the malakoplakia may appear rash-like with small areas of itchy, reddened skin that may be painful and/or fluid filled. The cause of malakoplakia is not well understood. It is thought to be related to an issue with the function of one's macrophages, which are one type of cell within the immune system that respond to foreign invaders (bacteria ). E.coli is the most common type of bacteria that leads to malakoplakia. Individuals with a compromised immune system have an elevated risk to develop malakoplakia. Treatment typically begins with antibiotics .

MalaCards based summary : Malakoplakia, also known as malacoplakia, is related to prostatic malacoplakia associated with prostatic abscess and colonic malakoplakia, and has symptoms including muscle weakness and polydipsia. Affiliated tissues include prostate, colon and kidney, and related phenotypes are proteinuria and fever

Wikipedia : 74 Malakoplakia (from Greek Malako "soft" + Plako "plaque") is a rare inflammatory condition which makes... more...

Related Diseases for Malakoplakia

Diseases related to Malakoplakia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 201)
# Related Disease Score Top Affiliating Genes
1 prostatic malacoplakia associated with prostatic abscess 12.4
2 colonic malakoplakia 12.4
3 acute cystitis 10.5
4 pyelonephritis 10.4
5 xanthogranulomatous pyelonephritis 10.4
6 adenocarcinoma 10.4
7 kidney disease 10.4
8 immune deficiency disease 10.3
9 cystitis 10.3
10 chronic granulomatous disease 10.3
11 acquired immunodeficiency syndrome 10.3
12 interstitial nephritis 10.2
13 megalocytic interstitial nephritis 10.2
14 renal cell carcinoma, nonpapillary 10.2
15 sarcoidosis 1 10.2
16 agammaglobulinemia 10.2
17 acute kidney failure 10.2
18 hydronephrosis 10.1
19 diarrhea 10.1
20 adenoma 10.1
21 end stage renal disease 10.1
22 herpes simplex 10.1
23 ulcerative colitis 10.1
24 neonatal herpes 10.1
25 human immunodeficiency virus type 1 10.1
26 colorectal adenocarcinoma 10.1
27 colitis 10.1
28 bacterial infectious disease 10.1
29 urinary tract obstruction 10.1
30 posttransplant acute limbic encephalitis 10.1
31 suppressor of tumorigenicity 3 10.0
32 vesicoureteral reflux 1 10.0
33 suppression of tumorigenicity 12 10.0
34 obstructive nephropathy 10.0
35 protein-losing enteropathy 10.0
36 uremia 10.0
37 epididymo-orchitis 10.0
38 adrenogenital syndrome 10.0
39 autoimmune disease 10.0
40 systemic lupus erythematosus 10.0
41 prostate cancer 10.0
42 lymphoma, hodgkin, classic 10.0
43 inflammatory bowel disease 10.0
44 diffuse large b-cell lymphoma 10.0
45 villous adenoma 10.0
46 nephrosclerosis 10.0
47 neutropenia 10.0
48 pancytopenia 10.0
49 klebsiella pneumonia 10.0
50 pyuria 10.0

Graphical network of the top 20 diseases related to Malakoplakia:



Diseases related to Malakoplakia

Symptoms & Phenotypes for Malakoplakia

Human phenotypes related to Malakoplakia:

58 31 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 proteinuria 58 31 hallmark (90%) Very frequent (99-80%) HP:0000093
2 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
3 skin rash 58 31 hallmark (90%) Very frequent (99-80%) HP:0000988
4 pruritus 58 31 hallmark (90%) Very frequent (99-80%) HP:0000989
5 subcutaneous nodule 58 31 hallmark (90%) Very frequent (99-80%) HP:0001482
6 papule 58 31 hallmark (90%) Very frequent (99-80%) HP:0200034
7 skin ulcer 58 31 hallmark (90%) Very frequent (99-80%) HP:0200042
8 hematuria 58 31 hallmark (90%) Very frequent (99-80%) HP:0000790
9 abdominal pain 58 31 hallmark (90%) Very frequent (99-80%) HP:0002027
10 abnormality of the menstrual cycle 58 31 hallmark (90%) Very frequent (99-80%) HP:0000140
11 abnormal bleeding 58 31 hallmark (90%) Very frequent (99-80%) HP:0001892
12 dysuria 58 31 hallmark (90%) Very frequent (99-80%) HP:0100518
13 diarrhea 58 31 hallmark (90%) Very frequent (99-80%) HP:0002014
14 urinary urgency 58 31 hallmark (90%) Very frequent (99-80%) HP:0000012
15 urinary hesitancy 58 31 hallmark (90%) Very frequent (99-80%) HP:0000019
16 urinary bladder inflammation 58 31 hallmark (90%) Very frequent (99-80%) HP:0100577
17 immunodeficiency 58 31 frequent (33%) Frequent (79-30%) HP:0002721
18 follicular hyperplasia 58 31 frequent (33%) Frequent (79-30%) HP:0002729
19 cough 58 31 occasional (7.5%) Occasional (29-5%) HP:0012735
20 chest pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0100749
21 abnormality of the neck 58 31 occasional (7.5%) Occasional (29-5%) HP:0000464
22 neoplasm of the colon 58 31 occasional (7.5%) Occasional (29-5%) HP:0100273
23 neoplasm of the rectum 58 31 occasional (7.5%) Occasional (29-5%) HP:0100743
24 abnormality of the tongue 58 31 occasional (7.5%) Occasional (29-5%) HP:0000157
25 orchitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100796
26 prostate neoplasm 58 31 occasional (7.5%) Occasional (29-5%) HP:0100787
27 inflammatory abnormality of the skin 58 Very frequent (99-80%)

UMLS symptoms related to Malakoplakia:


muscle weakness, polydipsia

Drugs & Therapeutics for Malakoplakia

Search Clinical Trials , NIH Clinical Center for Malakoplakia

Genetic Tests for Malakoplakia

Anatomical Context for Malakoplakia

MalaCards organs/tissues related to Malakoplakia:

40
Prostate, Colon, Kidney, Skin, Lung, Bone, Thyroid

Publications for Malakoplakia

Articles related to Malakoplakia:

(show top 50) (show all 1023)
# Title Authors PMID Year
1
Mischievous malakoplakia: A potential pitfall of mpMRI of the prostate? 61
32373473 2020
2
Appendiceal malakoplakia masquerading as a cecal mass. 61
32509269 2020
3
Gallbladder malakoplakia masquerading as malignant primary on 18F-FDG PET/CT. 61
32405736 2020
4
Renal malakoplakia mimicking a malignancy and diagnosed by fine-needle aspiration: A case report. 61
32359126 2020
5
Colonic malakoplakia in a cardiac transplant recipient: A case report. 61
32317546 2020
6
Fatal progression of experimental visceral leishmaniasis is associated with intestinal parasitism and secondary infection by commensal bacteria, and is delayed by antibiotic prophylaxis. 61
32282850 2020
7
Gastrointestinal Malakoplakia: Clinicopathologic Analysis of 26 Cases. 61
32301754 2020
8
Radiographic and Endoscopic Features of Pancreaticoduodenal Malakoplakia. 61
32168251 2020
9
Ultrastructural evidence of the evolutional process in malakoplakia. 61
31298302 2020
10
Pulmonary Malakoplakia by Rhodococcus equi in an HIV-Infected Patient in Mexico: A Case Report. 61
32318299 2020
11
Bladder Malakoplakia Simulating Neoplasm in a Young Girl: Report of a Case and Review of Literature. 61
30596224 2019
12
[Penile malakoplakia associated with lichen sclerosus]. 61
31627929 2019
13
Bilateral Ovarian Malacoplakia: Case Report and Review of the Literature With Clinical and Diagnostic Considerations. 61
31851062 2019
14
Imaging Manifestations of Acute and Chronic Renal Infection That Mimics Malignancy: How to Make the Diagnosis Using Computed Tomography and Magnetic Resonance Imaging. 61
31537315 2019
15
Cecal Malakoplakia - an Unusual Cause of Anemia in Liver Cirrhosis. 61
31517320 2019
16
Malakoplakia of the Bladder in a 4-Month-Old Puppy. 61
31433228 2019
17
von Hansemann Cells from Fresh Urine Sediment Samples in the Diagnosis of Malakoplakia. 61
31359917 2019
18
Malakoplakia of the Urinary Bladder and Unilateral Ureter. 61
31133162 2019
19
Malacoplakia of the skin: overview of a rare clinical entity. 61
31329385 2019
20
Malakoplakia of the parotid gland: a case report and review of localised malakoplakia of the head and neck. 61
30855168 2019
21
Cutaneous malakoplakia presenting as a groin swelling and graft failure. 61
31015237 2019
22
Malakoplakia in Thoracic Transplant Recipients. 61
30979478 2019
23
Malakoplakia of the colon following renal transplantation in a 73 year old woman: report of a case presenting as intestinal perforation. 61
30866984 2019
24
Fetal cerebral malakoplakia associated with recurrent facial erysipelas of the mother. 61
30563611 2019
25
Cutaneous Malakoplakia. 61
30726684 2019
26
Pulmonary malakoplakia secondary to Rhodococcus equi infection mimicking a lung neoplasm in a lung transplant recipient. 61
30063120 2019
27
Malakoplakia in Association with Adenocarcinoma of Sigmoid Colon; A Case Report. 61
31583004 2019
28
Malakoplakia of the urinary system. 61
31659350 2019
29
Chronic Diarrhea Related to Colonic Malakoplakia Successfully Treated with Budesonide in a Kidney Transplant Recipient. 61
30356178 2018
30
Malakoplakia complicating cutaneous septic vasculitis in an immunosuppressed liver transplant patient. 61
30530424 2018
31
Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders. 61
30366790 2018
32
An Unusual Association of Renal Cell Carcinoma and Renal Malakoplakia with Focal Segmental Glomerulosclerosis in an Elderly Patient. 61
30647507 2018
33
A case of primary cutaneous malakoplakia in a cardiac transplant recipient. 61
30406173 2018
34
Multiple extensive malacoplakia mimicking metastatic carcinoma. 61
29417571 2018
35
Malakoplakia as a cause of severe hypercalcemia through ectopic 25-hydroxyvitamin D3 1-alpha-hydroxylase expression: A case report. 61
30290590 2018
36
Colorectal malakoplakia in a patient with hypogammaglobulinemia. 61
29627491 2018
37
A novel cause of postmenopausal bleeding in an immunosuppressed patient. 61
29991552 2018
38
Case - Malakoplakia in a 58-year-old male following living donor renal transplantation. 61
30059290 2018
39
Malakoplakia of the prostate diagnosed on multiparametric-MRI ultrasound fusion guided biopsy: A case report and review of the literature. 61
29785385 2018
40
Colonic Malakoplakia: A Rare Finding in a Healthy Male. 61
30186099 2018
41
Fluorodeoxyglucose avid malakoplakia of the laryngohypopharynx masquerading as malignant tumor: A pathological enigma and clinical dilemma. 61
29676386 2018
42
Renal malakoplakia mimicking a locally advanced renal mass: A case report. 61
29541596 2018
43
Phenotypic appearances of prostate utilizing PET-MRI and PET-CT with 68Ga-PSMA, radiolabelled choline and 68Ga-DOTATATE. 61
29384832 2018
44
Malakoplakia of the large intestine: an incidental extremely rare finding. 61
29694309 2018
45
Bilateral hydroureteronephrosis with renal failure caused by malacoplakia. 61
28967059 2018
46
No significant risk of secondary prostatic cancer in a patient with prostatic malakoplakia after a four-year follow-up. 61
31949808 2018
47
Bladder Malakoplakia in Systemic Sclerosis Patient: A Case Report and Review Literature. 61
29967807 2018
48
Malakoplakia after kidney transplantation: Case report and literature review. 61
28561517 2017
49
Cutaneous malakoplakia: Interesting case report and review of literature. 61
28749381 2017
50
Cutaneous malakoplakia masquerading as pyoderma gangrenosum. 61
27524799 2017

Variations for Malakoplakia

Expression for Malakoplakia

Search GEO for disease gene expression data for Malakoplakia.

Pathways for Malakoplakia

GO Terms for Malakoplakia

Sources for Malakoplakia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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