MCID: MLK004
MIFTS: 31

Malakoplakia

Categories: Gastrointestinal diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Malakoplakia

MalaCards integrated aliases for Malakoplakia:

Name: Malakoplakia 53 59
Malacoplakia 53 17 72

Characteristics:

Orphanet epidemiological data:

59
malakoplakia
Age of onset: Adult; Age of death: adult;

Classifications:



External Ids:

Orphanet 59 ORPHA556
UMLS 72 C0024525

Summaries for Malakoplakia

NIH Rare Diseases : 53 Malakoplakia is a rare chronic inflammatory disease. It most commonly involves the urogenital system (reproductive organs and urinary system), but may also be found in other regions of the body, including the pelvis, bones, lungs, thyroid gland, gastrointestinal (digestive) tract, skin, and kidneys. Symptoms of malakoplakia differ depending on the involved area. For example, when the skin is affected the malakoplakia may appear rash-like with small areas of itchy, reddened skin that may be painful and/or fluid filled. The cause of malakoplakia is not well understood. It is thought to be related to an issue with the function of one's macrophages, which are one type of cell within the immune system that respond to foreign invaders (bacteria). E.coli is the most common type of bacteria that leads to malakoplakia. Individuals with a compromised immune system have an elevated risk to develop malakoplakia. Treatment typically begins with antibiotics.

MalaCards based summary : Malakoplakia, also known as malacoplakia, is related to prostatic malacoplakia associated with prostatic abscess and colonic malakoplakia, and has symptoms including muscle weakness and polydipsia. Affiliated tissues include prostate, kidney and colon, and related phenotypes are proteinuria and fever

Wikipedia : 75 Malakoplakia (from Greek Malako "soft" + Plako "plaque") is a rare inflammatory condition which makes... more...

Related Diseases for Malakoplakia

Diseases related to Malakoplakia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 206)
# Related Disease Score Top Affiliating Genes
1 prostatic malacoplakia associated with prostatic abscess 12.4
2 colonic malakoplakia 12.4
3 acute cystitis 10.5
4 pyelonephritis 10.4
5 xanthogranulomatous pyelonephritis 10.4
6 adenocarcinoma 10.4
7 kidney disease 10.4
8 immune deficiency disease 10.3
9 cystitis 10.3
10 chronic granulomatous disease 10.3
11 acquired immunodeficiency syndrome 10.3
12 interstitial nephritis 10.2
13 megalocytic interstitial nephritis 10.2
14 renal cell carcinoma, nonpapillary 10.2
15 sarcoidosis 1 10.2
16 agammaglobulinemia 10.2
17 acute kidney failure 10.2
18 hydronephrosis 10.1
19 diarrhea 10.1
20 adenoma 10.1
21 end stage renal failure 10.1
22 herpes simplex 10.1
23 ulcerative colitis 10.1
24 neonatal herpes 10.1
25 congenital herpes simplex virus infection 10.1
26 human immunodeficiency virus type 1 10.1
27 colorectal adenocarcinoma 10.1
28 lymphoma 10.1
29 colitis 10.1
30 urinary tract obstruction 10.1
31 suppressor of tumorigenicity 3 10.0
32 vesicoureteral reflux 1 10.0
33 suppression of tumorigenicity 12 10.0
34 obstructive nephropathy 10.0
35 protein-losing enteropathy 10.0
36 uremia 10.0
37 epididymo-orchitis 10.0
38 adrenogenital syndrome 10.0
39 autoimmune disease 10.0
40 systemic lupus erythematosus 10.0
41 prostate cancer 10.0
42 lymphoma, hodgkin, classic 10.0
43 inflammatory bowel disease 10.0
44 diffuse large b-cell lymphoma 10.0
45 villous adenoma 10.0
46 thrombosis 10.0
47 bacterial infectious disease 10.0
48 nephrosclerosis 10.0
49 neutropenia 10.0
50 pancytopenia 10.0

Graphical network of the top 20 diseases related to Malakoplakia:



Diseases related to Malakoplakia

Symptoms & Phenotypes for Malakoplakia

Human phenotypes related to Malakoplakia:

59 32 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 proteinuria 59 32 hallmark (90%) Very frequent (99-80%) HP:0000093
2 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
3 subcutaneous nodule 59 32 hallmark (90%) Very frequent (99-80%) HP:0001482
4 abnormal bleeding 59 32 hallmark (90%) Very frequent (99-80%) HP:0001892
5 abdominal pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0002027
6 pruritus 59 32 hallmark (90%) Very frequent (99-80%) HP:0000989
7 skin rash 59 32 hallmark (90%) Very frequent (99-80%) HP:0000988
8 papule 59 32 hallmark (90%) Very frequent (99-80%) HP:0200034
9 skin ulcer 59 32 hallmark (90%) Very frequent (99-80%) HP:0200042
10 hematuria 59 32 hallmark (90%) Very frequent (99-80%) HP:0000790
11 diarrhea 59 32 hallmark (90%) Very frequent (99-80%) HP:0002014
12 abnormality of the menstrual cycle 59 32 hallmark (90%) Very frequent (99-80%) HP:0000140
13 urinary urgency 59 32 hallmark (90%) Very frequent (99-80%) HP:0000012
14 dysuria 59 32 hallmark (90%) Very frequent (99-80%) HP:0100518
15 urinary hesitancy 59 32 hallmark (90%) Very frequent (99-80%) HP:0000019
16 urinary bladder inflammation 59 32 hallmark (90%) Very frequent (99-80%) HP:0100577
17 immunodeficiency 59 32 frequent (33%) Frequent (79-30%) HP:0002721
18 follicular hyperplasia 59 32 frequent (33%) Frequent (79-30%) HP:0002729
19 cough 59 32 occasional (7.5%) Occasional (29-5%) HP:0012735
20 chest pain 59 32 occasional (7.5%) Occasional (29-5%) HP:0100749
21 abnormality of the neck 59 32 occasional (7.5%) Occasional (29-5%) HP:0000464
22 neoplasm of the colon 59 32 occasional (7.5%) Occasional (29-5%) HP:0100273
23 neoplasm of the rectum 59 32 occasional (7.5%) Occasional (29-5%) HP:0100743
24 abnormality of the tongue 59 32 occasional (7.5%) Occasional (29-5%) HP:0000157
25 orchitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0100796
26 prostate neoplasm 59 32 occasional (7.5%) Occasional (29-5%) HP:0100787
27 inflammatory abnormality of the skin 59 Very frequent (99-80%)

UMLS symptoms related to Malakoplakia:


muscle weakness, polydipsia

Drugs & Therapeutics for Malakoplakia

Search Clinical Trials , NIH Clinical Center for Malakoplakia

Genetic Tests for Malakoplakia

Anatomical Context for Malakoplakia

MalaCards organs/tissues related to Malakoplakia:

41
Prostate, Kidney, Colon, Skin, Lung, Bone, Thyroid

Publications for Malakoplakia

Articles related to Malakoplakia:

(show top 50) (show all 1006)
# Title Authors PMID Year
1
Malakoplakia of the Bladder in a 4-Month-Old Puppy. 38
31433228 2019
2
von Hansemann Cells from Fresh Urine Sediment Samples in the Diagnosis of Malakoplakia. 38
31359917 2019
3
Ultrastructural evidence of the evolutional process in malakoplakia. 38
31298302 2019
4
Malakoplakia of the Urinary Bladder and Unilateral Ureter. 38
31133162 2019
5
Malacoplakia of the skin: overview of a rare clinical entity. 38
31329385 2019
6
Malakoplakia of the parotid gland: a case report and review of localised malakoplakia of the head and neck. 38
30855168 2019
7
Cutaneous malakoplakia presenting as a groin swelling and graft failure. 38
31015237 2019
8
Malakoplakia in Thoracic Transplant Recipients. 38
30979478 2019
9
Fetal cerebral malakoplakia associated with recurrent facial erysipelas of the mother. 38
30563611 2019
10
Malakoplakia of the colon following renal transplantation in a 73 year old woman: report of a case presenting as intestinal perforation. 38
30866984 2019
11
Cutaneous Malakoplakia. 38
30726684 2019
12
Pulmonary malakoplakia secondary to Rhodococcus equi infection mimicking a lung neoplasm in a lung transplant recipient. 38
30063120 2019
13
Bladder Malakoplakia Simulating Neoplasm in a Young Girl: Report of a Case and Review of Literature. 38
30596224 2018
14
Malakoplakia complicating cutaneous septic vasculitis in an immunosuppressed liver transplant patient. 38
30530424 2018
15
Chronic Diarrhea Related to Colonic Malakoplakia Successfully Treated with Budesonide in a Kidney Transplant Recipient. 38
30356178 2018
16
An Unusual Association of Renal Cell Carcinoma and Renal Malakoplakia with Focal Segmental Glomerulosclerosis in an Elderly Patient. 38
30647507 2018
17
Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders. 38
30366790 2018
18
A case of primary cutaneous malakoplakia in a cardiac transplant recipient. 38
30406173 2018
19
Multiple extensive malacoplakia mimicking metastatic carcinoma. 38
29417571 2018
20
Malakoplakia as a cause of severe hypercalcemia through ectopic 25-hydroxyvitamin D3 1-alpha-hydroxylase expression: A case report. 38
30290590 2018
21
Colorectal malakoplakia in a patient with hypogammaglobulinemia. 38
29627491 2018
22
A novel cause of postmenopausal bleeding in an immunosuppressed patient. 38
29991552 2018
23
Case - Malakoplakia in a 58-year-old male following living donor renal transplantation. 38
30059290 2018
24
Malakoplakia of the prostate diagnosed on multiparametric-MRI ultrasound fusion guided biopsy: A case report and review of the literature. 38
29785385 2018
25
Colonic Malakoplakia: A Rare Finding in a Healthy Male. 38
30186099 2018
26
Fluorodeoxyglucose avid malakoplakia of the laryngohypopharynx masquerading as malignant tumor: A pathological enigma and clinical dilemma. 38
29676386 2018
27
Renal malakoplakia mimicking a locally advanced renal mass: A case report. 38
29541596 2018
28
Phenotypic appearances of prostate utilizing PET-MRI and PET-CT with 68Ga-PSMA, radiolabelled choline and 68Ga-DOTATATE. 38
29384832 2018
29
Malakoplakia of the large intestine: an incidental extremely rare finding. 38
29694309 2018
30
Bilateral hydroureteronephrosis with renal failure caused by malacoplakia. 38
28967059 2018
31
Bladder Malakoplakia in Systemic Sclerosis Patient: A Case Report and Review Literature. 38
29967807 2018
32
Malakoplakia after kidney transplantation: Case report and literature review. 38
28561517 2017
33
Cutaneous malakoplakia: Interesting case report and review of literature. 38
28749381 2017
34
Cutaneous malakoplakia masquerading as pyoderma gangrenosum. 38
27524799 2017
35
Malakoplakia Presenting as an Endobronchial Lesion in a Human Immunodeficiency Virus-Positive Man. 38
28864380 2017
36
Granulomatous & histiocytic dermatitides. 38
28094163 2017
37
Rectosigmoid malakoplakia. 38
28566412 2017
38
Malacoplakia mimicking colonic malignancy: A case report. 38
29446821 2017
39
Malakoplakia of the Prostate as a Mimicker of Prostate Cancer on Prostate Health Index and Magnetic Resonance Imaging-Fusion Prostate Biopsy: A Case Report. 38
28736746 2017
40
A case of gallbladder mass: Malakoplakia (The tumor mimicker). 38
28195110 2017
41
Enteral Malakoplakia Prior to Helicobacter cinaedi Bacteremia. 38
28050043 2017
42
Nonhealing surgical wound due to cutaneous malakoplakia. 38
27935636 2017
43
Complicated Genitourinary Tract Infections and Mimics. 38
26995297 2017
44
Isolated urachal malakoplakia mimicking malignancy. 38
28216941 2017
45
A Case of Cutaneous Malakoplakia in the Head and Neck Region and Review of the Literature. 38
27154024 2016
46
AJKD Atlas of Renal Pathology: Malakoplakia. 38
27664482 2016
47
Malakoplakia Associated With Multiple Adenomas of the Colon: An Extremely Rare Incidental Finding. 38
26912474 2016
48
Malakoplakia of the Urinary Bladder in a Patient with Chronic Lymphocytic Leukemia Under Ibrutinib Therapy: A Case Report. 38
27630324 2016
49
Renal Parenchymal Malakoplakia Presenting as Acute Renal Failure in a Young Woman. 38
27453243 2016
50
Beyond ureterolithiasis: gamut of abnormalities affecting the ureter. 38
27317212 2016

Variations for Malakoplakia

Expression for Malakoplakia

Search GEO for disease gene expression data for Malakoplakia.

Pathways for Malakoplakia

GO Terms for Malakoplakia

Sources for Malakoplakia

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10 dbSNP
11 DGIdb
17 EFO
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19 FMA
28 GO
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33 ICD10
34 ICD10 via Orphanet
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49 NCI
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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