MCID: MLK004
MIFTS: 34

Malakoplakia

Categories: Gastrointestinal diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Malakoplakia

MalaCards integrated aliases for Malakoplakia:

Name: Malakoplakia 54 60
Malacoplakia 54 17 74

Characteristics:

Orphanet epidemiological data:

60
malakoplakia
Age of onset: Adult; Age of death: adult;

Classifications:



Summaries for Malakoplakia

NIH Rare Diseases : 54 Malakoplakia is a rare chronic inflammatory disease. It most commonly involves the urogenital system (reproductive organs and urinary system), but may also be found in other regions of the body, including the pelvis, bones, lungs, thyroid gland, gastrointestinal (digestive) tract, skin, and kidneys. Symptoms of malakoplakia differ depending on the involved area. For example, when the skin is affected the malakoplakia may appear rash-like with small areas of itchy, reddened skin that may be painful and/or fluid filled. The cause of malakoplakia is not well understood. It is thought to be related to an issue with the function of one's macrophages, which are one type of cell within the immune system that respond to foreign invaders (bacteria). E.coli is the most common type of bacteria that leads to malakoplakia. Individuals with a compromised immune system have an elevated risk to develop malakoplakia. Treatment typically begins with antibiotics.

MalaCards based summary : Malakoplakia, also known as malacoplakia, is related to prostatic malacoplakia associated with prostatic abscess and colonic malakoplakia, and has symptoms including muscle weakness and polydipsia. Affiliated tissues include prostate, colon and kidney, and related phenotypes are proteinuria and fever

Wikipedia : 77 Malakoplakia (from Greek Malako "soft" + Plako "plaque") is a rare inflammatory condition which makes... more...

Related Diseases for Malakoplakia

Diseases related to Malakoplakia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 prostatic malacoplakia associated with prostatic abscess 12.3
2 colonic malakoplakia 12.3
3 adenocarcinoma 10.3
4 pyelonephritis 10.2
5 xanthogranulomatous pyelonephritis 10.2
6 lymphoma 10.1
7 acquired immunodeficiency syndrome 10.1
8 renal cell carcinoma, nonpapillary 10.0
9 ulcerative colitis 10.0
10 colitis 10.0
11 interstitial nephritis 10.0
12 cystitis 10.0
13 agammaglobulinemia 10.0
14 adenoma 10.0
15 megalocytic interstitial nephritis 10.0
16 systemic lupus erythematosus 9.9
17 prostate cancer 9.9
18 prostate cancer, hereditary, 8 9.9
19 prostate cancer, hereditary, 6 9.9
20 colorectal adenocarcinoma 9.9
21 thrombosis 9.9
22 diarrhea 9.9
23 histiocytosis 9.9
24 lupus erythematosus 9.9
25 neonatal herpes 9.9
26 immunoglobulin a deficiency 1 9.9
27 congenital anomalies of kidney and urinary tract 2 9.9
28 vesicoureteral reflux 1 9.9
29 glomerulonephritis 9.9
30 abdominal tuberculosis 9.9
31 obstructive nephropathy 9.9
32 urethral stricture 9.9
33 transitional cell carcinoma 9.9
34 granuloma inguinale 9.9
35 epididymo-orchitis 9.9
36 rosai-dorfman disease 9.9
37 urachal cancer 9.9
38 leukemia, chronic lymphocytic 2 9.8
39 bladder cancer 9.8
40 leukemia, chronic lymphocytic 9.8
41 pemphigus vulgaris, familial 9.8
42 pelvic organ prolapse 9.8
43 scleroderma, familial progressive 9.8
44 lung cancer 9.8
45 celiac disease 1 9.8
46 charge syndrome 9.8
47 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.8
48 focal segmental glomerulosclerosis 1 9.8
49 cervical cancer 9.8
50 myelodysplastic syndrome 9.8

Graphical network of the top 20 diseases related to Malakoplakia:



Diseases related to Malakoplakia

Symptoms & Phenotypes for Malakoplakia

Human phenotypes related to Malakoplakia:

60 33 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 proteinuria 60 33 hallmark (90%) Very frequent (99-80%) HP:0000093
2 fever 60 33 hallmark (90%) Very frequent (99-80%) HP:0001945
3 subcutaneous nodule 60 33 hallmark (90%) Very frequent (99-80%) HP:0001482
4 abnormal bleeding 60 33 hallmark (90%) Very frequent (99-80%) HP:0001892
5 abdominal pain 60 33 hallmark (90%) Very frequent (99-80%) HP:0002027
6 pruritus 60 33 hallmark (90%) Very frequent (99-80%) HP:0000989
7 skin ulcer 60 33 hallmark (90%) Very frequent (99-80%) HP:0200042
8 hematuria 60 33 hallmark (90%) Very frequent (99-80%) HP:0000790
9 diarrhea 60 33 hallmark (90%) Very frequent (99-80%) HP:0002014
10 skin rash 60 33 hallmark (90%) Very frequent (99-80%) HP:0000988
11 abnormality of the menstrual cycle 60 33 hallmark (90%) Very frequent (99-80%) HP:0000140
12 papule 60 33 hallmark (90%) Very frequent (99-80%) HP:0200034
13 urinary urgency 60 33 hallmark (90%) Very frequent (99-80%) HP:0000012
14 dysuria 60 33 hallmark (90%) Very frequent (99-80%) HP:0100518
15 urinary hesitancy 60 33 hallmark (90%) Very frequent (99-80%) HP:0000019
16 urinary bladder inflammation 60 33 hallmark (90%) Very frequent (99-80%) HP:0100577
17 immunodeficiency 60 33 frequent (33%) Frequent (79-30%) HP:0002721
18 follicular hyperplasia 60 33 frequent (33%) Frequent (79-30%) HP:0002729
19 chest pain 60 33 occasional (7.5%) Occasional (29-5%) HP:0100749
20 cough 60 33 occasional (7.5%) Occasional (29-5%) HP:0012735
21 abnormality of the neck 60 33 occasional (7.5%) Occasional (29-5%) HP:0000464
22 neoplasm of the colon 60 33 occasional (7.5%) Occasional (29-5%) HP:0100273
23 neoplasm of the rectum 60 33 occasional (7.5%) Occasional (29-5%) HP:0100743
24 abnormality of the tongue 60 33 occasional (7.5%) Occasional (29-5%) HP:0000157
25 orchitis 60 33 occasional (7.5%) Occasional (29-5%) HP:0100796
26 prostate neoplasm 60 33 occasional (7.5%) Occasional (29-5%) HP:0100787
27 inflammatory abnormality of the skin 60 Very frequent (99-80%)

UMLS symptoms related to Malakoplakia:


muscle weakness, polydipsia

Drugs & Therapeutics for Malakoplakia

Search Clinical Trials , NIH Clinical Center for Malakoplakia

Genetic Tests for Malakoplakia

Anatomical Context for Malakoplakia

MalaCards organs/tissues related to Malakoplakia:

42
Prostate, Colon, Kidney, Skin, Thyroid, Lung, Bone

Publications for Malakoplakia

Articles related to Malakoplakia:

(show top 50) (show all 690)
# Title Authors Year
1
Malakoplakia of the colon following renal transplantation in a 73 year old woman: report of a case presenting as intestinal perforation. ( 30866984 )
2019
2
Pulmonary malakoplakia secondary to Rhodococcus equi infection mimicking a lung neoplasm in a lung transplant recipient. ( 30063120 )
2019
3
Cutaneous Malakoplakia. ( 30726684 )
2019
4
Malakoplakia of the parotid gland: a case report and review of localised malakoplakia of the head and neck. ( 30855168 )
2019
5
Malakoplakia in Thoracic Transplant Recipients. ( 30979478 )
2019
6
Cutaneous malakoplakia presenting as a groin swelling and graft failure. ( 31015237 )
2019
7
Colonic Malakoplakia: A Rare Finding in a Healthy Male. ( 30186099 )
2018
8
Chronic Diarrhea Related to Colonic Malakoplakia Successfully Treated with Budesonide in a Kidney Transplant Recipient. ( 30356178 )
2018
9
Fetal cerebral malakoplakia associated with recurrent facial erysipelas of the mother. ( 30563611 )
2018
10
Renal malakoplakia mimicking a locally advanced renal mass: A case report. ( 29541596 )
2018
11
Colorectal malakoplakia in a patient with hypogammaglobulinemia. ( 29627491 )
2018
12
Fluorodeoxyglucose avid malakoplakia of the laryngohypopharynx masquerading as malignant tumor: A pathological enigma and clinical dilemma. ( 29676386 )
2018
13
Malakoplakia of the large intestine: an incidental extremely rare finding. ( 29694309 )
2018
14
Malakoplakia of the prostate diagnosed on multiparametric-MRI ultrasound fusion guided biopsy: A case report and review of the literature. ( 29785385 )
2018
15
Bladder Malakoplakia in Systemic Sclerosis Patient: A Case Report and Review Literature. ( 29967807 )
2018
16
Case - Malakoplakia in a 58-year-old male following living donor renal transplantation. ( 30059290 )
2018
17
Malakoplakia as a cause of severe hypercalcemia through ectopic 25-hydroxyvitamin D3 1-alpha-hydroxylase expression: A case report. ( 30290590 )
2018
18
A case of primary cutaneous malakoplakia in a cardiac transplant recipient. ( 30406173 )
2018
19
Malakoplakia complicating cutaneous septic vasculitis in an immunosuppressed liver transplant patient. ( 30530424 )
2018
20
An Unusual Association of Renal Cell Carcinoma and Renal Malakoplakia with Focal Segmental Glomerulosclerosis in an Elderly Patient. ( 30647507 )
2018
21
Bladder Malakoplakia Simulating Neoplasm in a Young Girl: Report of a Case and Review of Literature. ( 30596224 )
2018
22
Bilateral hydroureteronephrosis with renal failure caused by malacoplakia. ( 28967059 )
2018
23
Multiple extensive malacoplakia mimicking metastatic carcinoma. ( 29417571 )
2018
24
Cutaneous malakoplakia masquerading as pyoderma gangrenosum. ( 27524799 )
2017
25
Nonhealing surgical wound due to cutaneous malakoplakia. ( 27935636 )
2017
26
Enteral Malakoplakia Prior to Helicobacter cinaedi Bacteremia. ( 28050043 )
2017
27
A case of gallbladder mass: Malakoplakia (The tumor mimicker). ( 28195110 )
2017
28
Isolated urachal malakoplakia mimicking malignancy. ( 28216941 )
2017
29
Malakoplakia after kidney transplantation: Case report and literature review. ( 28561517 )
2017
30
Rectosigmoid malakoplakia. ( 28566412 )
2017
31
Malakoplakia of the Prostate as a Mimicker of Prostate Cancer on Prostate Health Index and Magnetic Resonance Imaging-Fusion Prostate Biopsy: A Case Report. ( 28736746 )
2017
32
Cutaneous malakoplakia: Interesting case report and review of literature. ( 28749381 )
2017
33
Malakoplakia Presenting as an Endobronchial Lesion in a Human Immunodeficiency Virus-Positive Man. ( 28864380 )
2017
34
Malacoplakia mimicking colonic malignancy: A case report. ( 29446821 )
2017
35
Malakoplakia of the Urinary Bladder in a Patient with Chronic Lymphocytic Leukemia Under Ibrutinib Therapy: A Case Report. ( 27630324 )
2016
36
A 13-Month-Old With Xanthogranulomatous Pyelonephritis With Features of Renal Malakoplakia. ( 26894199 )
2016
37
Malakoplakia Associated With Multiple Adenomas of the Colon: An Extremely Rare Incidental Finding. ( 26912474 )
2016
38
Co-existing malakoplakia and xanthogranulomatous pyelonephritis of kidney: Two different spectrum of same disease process. ( 27141206 )
2016
39
A Case of Cutaneous Malakoplakia in the Head and Neck Region and Review of the Literature. ( 27154024 )
2016
40
Malakoplakia associated with prostatic adenocarcinoma: Report of 4 cases and literature review. ( 27180057 )
2016
41
Renal Parenchymal Malakoplakia Presenting as Acute Renal Failure in a Young Woman. ( 27453243 )
2016
42
AJKD Atlas of Renal Pathology: Malakoplakia. ( 27664482 )
2016
43
Successful treatment of vaginal malakoplakia in a young cat. ( 28491441 )
2016
44
Uterine malakoplakia diagnosed in a cervical Pap smear. ( 25900733 )
2016
45
A case of pseudotumoral malakoplakia following pathologic complete response in rectal cancer. ( 26136124 )
2016
46
Malakoplakia After Allogeneic Hematopoietic Stem Cell Transplantation. ( 26302286 )
2015
47
Xanthogranulomatous cystitis with malacoplakia, leading to spontaneous intraperitoneal perforation of the urinary bladder in a 9-year-old girl. ( 26272961 )
2015
48
Malakoplakia in a patient with complicated urinary tract infection caused by extended-spectrum β-lactamase-producing Escherichia coli. ( 24530255 )
2015
49
Testicular malakoplakia: a rare sonographic mimic of malignancy. ( 25237793 )
2015
50
Malakoplakia of the thyroid gland: a case report and review of literature. ( 25663335 )
2015

Variations for Malakoplakia

Expression for Malakoplakia

Search GEO for disease gene expression data for Malakoplakia.

Pathways for Malakoplakia

GO Terms for Malakoplakia

Sources for Malakoplakia

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75 UMLS via Orphanet
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