MCID: MLK004
MIFTS: 35

Malakoplakia

Categories: Gastrointestinal diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Malakoplakia

MalaCards integrated aliases for Malakoplakia:

Name: Malakoplakia 53 59
Malacoplakia 53 73

Characteristics:

Orphanet epidemiological data:

59
malakoplakia
Age of onset: Adult; Age of death: adult;

Classifications:



Summaries for Malakoplakia

NIH Rare Diseases : 53 Malakoplakia is a rare chronic inflammatory disease. It most commonly involves the urogenital system (reproductive organs and urinary system), but may also be found in other regions of the body, including the pelvis, bones, lungs, thyroid gland, gastrointestinal (digestive) tract, skin, and kidneys. Symptoms of malakoplakia differ depending on the involved area. For example, when the skin is affected the malakoplakia may appear rash-like with small areas of itchy, reddened skin that may be painful and/or fluid filled. The cause of malakoplakia is not well understood. It is thought to be related to an issue with the function of one's macrophages, which are one type of cell within the immune system that respond to foreign invaders (bacteria). E.coli is the most common type of bacteria that leads to malakoplakia. Individuals with a compromised immune system have an elevated risk to develop malakoplakia. Treatment typically begins with antibiotics.

MalaCards based summary : Malakoplakia, also known as malacoplakia, is related to prostatic malacoplakia associated with prostatic abscess and colonic malakoplakia, and has symptoms including muscle weakness and polydipsia. Affiliated tissues include prostate, colon and kidney, and related phenotypes are proteinuria and fever

Wikipedia : 76 Malakoplakia or malacoplakia (from Greek Malako "soft" + Plako "plaque") is a rare inflammatory... more...

Related Diseases for Malakoplakia

Diseases related to Malakoplakia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 prostatic malacoplakia associated with prostatic abscess 12.3
2 colonic malakoplakia 12.2
3 adenocarcinoma 10.3
4 pyelonephritis 10.2
5 xanthogranulomatous pyelonephritis 10.2
6 lymphoma 10.1
7 acquired immunodeficiency syndrome 10.1
8 ulcerative colitis 10.0
9 colitis 10.0
10 interstitial nephritis 10.0
11 cystitis 10.0
12 adenoma 10.0
13 megalocytic interstitial nephritis 10.0
14 renal cell carcinoma, nonpapillary 9.9
15 systemic lupus erythematosus 9.9
16 prostate cancer 9.9
17 colorectal adenocarcinoma 9.9
18 thrombosis 9.9
19 diarrhea 9.9
20 histiocytosis 9.9
21 lupus erythematosus 9.9
22 neonatal herpes 9.9
23 immunoglobulin a deficiency 1 9.9
24 congenital anomalies of kidney and urinary tract 2 9.9
25 vesicoureteral reflux 1 9.9
26 glomerulonephritis 9.9
27 abdominal tuberculosis 9.9
28 obstructive nephropathy 9.9
29 urethral stricture 9.9
30 transitional cell carcinoma 9.9
31 granuloma inguinale 9.9
32 epididymo-orchitis 9.9
33 rosai-dorfman disease 9.9
34 urachal cancer 9.9
35 leukemia, chronic lymphocytic 2 9.8
36 bladder cancer 9.8
37 diabetes mellitus, noninsulin-dependent 9.8
38 leukemia, chronic lymphocytic 9.8
39 pemphigus vulgaris, familial 9.8
40 pelvic organ prolapse 9.8
41 scleroderma, familial progressive 9.8
42 lung cancer 9.8
43 celiac disease 1 9.8
44 cervical cancer 9.8
45 myelodysplastic syndrome 9.8
46 b-cell lymphomas 9.8
47 chronic granulomatous disease 9.8
48 diabetes mellitus 9.8
49 diffuse large b-cell lymphoma 9.8
50 end stage renal failure 9.8

Graphical network of the top 20 diseases related to Malakoplakia:



Diseases related to Malakoplakia

Symptoms & Phenotypes for Malakoplakia

Human phenotypes related to Malakoplakia:

59 32 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 proteinuria 59 32 hallmark (90%) Very frequent (99-80%) HP:0000093
2 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
3 subcutaneous nodule 59 32 hallmark (90%) Very frequent (99-80%) HP:0001482
4 immunodeficiency 59 32 frequent (33%) Frequent (79-30%) HP:0002721
5 abnormal bleeding 59 32 hallmark (90%) Very frequent (99-80%) HP:0001892
6 abdominal pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0002027
7 pruritus 59 32 hallmark (90%) Very frequent (99-80%) HP:0000989
8 skin ulcer 59 32 hallmark (90%) Very frequent (99-80%) HP:0200042
9 hematuria 59 32 hallmark (90%) Very frequent (99-80%) HP:0000790
10 chest pain 59 32 occasional (7.5%) Occasional (29-5%) HP:0100749
11 diarrhea 59 32 hallmark (90%) Very frequent (99-80%) HP:0002014
12 skin rash 59 32 hallmark (90%) Very frequent (99-80%) HP:0000988
13 cough 59 32 occasional (7.5%) Occasional (29-5%) HP:0012735
14 abnormality of the menstrual cycle 59 32 hallmark (90%) Very frequent (99-80%) HP:0000140
15 abnormality of the neck 59 32 occasional (7.5%) Occasional (29-5%) HP:0000464
16 papule 59 32 hallmark (90%) Very frequent (99-80%) HP:0200034
17 neoplasm of the colon 59 32 occasional (7.5%) Occasional (29-5%) HP:0100273
18 neoplasm of the rectum 59 32 occasional (7.5%) Occasional (29-5%) HP:0100743
19 urinary urgency 59 32 hallmark (90%) Very frequent (99-80%) HP:0000012
20 dysuria 59 32 hallmark (90%) Very frequent (99-80%) HP:0100518
21 abnormality of the tongue 59 32 occasional (7.5%) Occasional (29-5%) HP:0000157
22 orchitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0100796
23 urinary hesitancy 59 32 hallmark (90%) Very frequent (99-80%) HP:0000019
24 follicular hyperplasia 59 32 frequent (33%) Frequent (79-30%) HP:0002729
25 urinary bladder inflammation 59 32 hallmark (90%) Very frequent (99-80%) HP:0100577
26 prostate neoplasm 59 32 occasional (7.5%) Occasional (29-5%) HP:0100787
27 inflammatory abnormality of the skin 59 Very frequent (99-80%)

UMLS symptoms related to Malakoplakia:


muscle weakness, polydipsia

Drugs & Therapeutics for Malakoplakia

Search Clinical Trials , NIH Clinical Center for Malakoplakia

Genetic Tests for Malakoplakia

Anatomical Context for Malakoplakia

MalaCards organs/tissues related to Malakoplakia:

41
Prostate, Colon, Kidney, Skin, Lung, Bone, Thyroid

Publications for Malakoplakia

Articles related to Malakoplakia:

(show top 50) (show all 673)
# Title Authors Year
1
Fluorodeoxyglucose avid malakoplakia of the laryngohypopharynx masquerading as malignant tumor: A pathological enigma and clinical dilemma. ( 29676386 )
2018
2
Colorectal malakoplakia in a patient with hypogammaglobulinemia. ( 29627491 )
2018
3
Renal malakoplakia mimicking a locally advanced renal mass: A case report. ( 29541596 )
2018
4
Bladder Malakoplakia in Systemic Sclerosis Patient: A Case Report and Review Literature. ( 29967807 )
2018
5
Malakoplakia of the large intestine: an incidental extremely rare finding. ( 29694309 )
2018
6
Colonic Malakoplakia: A Rare Finding in a Healthy Male. ( 30186099 )
2018
7
Chronic Diarrhea Related to Colonic Malakoplakia Successfully Treated with Budesonide in a Kidney Transplant Recipient. ( 30356178 )
2018
8
Malakoplakia of the prostate diagnosed on multiparametric-MRI ultrasound fusion guided biopsy: A case report and review of the literature. ( 29785385 )
2018
9
Case - Malakoplakia in a 58-year-old male following living donor renal transplantation. ( 30059290 )
2018
10
Pulmonary malakoplakia secondary to Rhodococcus equi infection mimicking a lung neoplasm in a lung transplant recipient. ( 30063120 )
2018
11
Malakoplakia as a cause of severe hypercalcemia through ectopic 25-hydroxyvitamin D3 1-alpha-hydroxylase expression: A case report. ( 30290590 )
2018
12
A case of primary cutaneous malakoplakia in a cardiac transplant recipient. ( 30406173 )
2018
13
Malakoplakia complicating cutaneous septic vasculitis in an immunosuppressed liver transplant patient. ( 30530424 )
2018
14
Bilateral hydroureteronephrosis with renal failure caused by malacoplakia. ( 28967059 )
2018
15
Multiple extensive malacoplakia mimicking metastatic carcinoma. ( 29417571 )
2018
16
Cutaneous malakoplakia: Interesting case report and review of literature. ( 28749381 )
2017
17
Malakoplakia Presenting as an Endobronchial Lesion in a Human Immunodeficiency Virus-Positive Man. ( 28864380 )
2017
18
Malakoplakia after kidney transplantation: Case report and literature review. ( 28561517 )
2017
19
A case of gallbladder mass: Malakoplakia (The tumor mimicker). ( 28195110 )
2017
20
Malakoplakia of the Prostate as a Mimicker of Prostate Cancer on Prostate Health Index and Magnetic Resonance Imaging-Fusion Prostate Biopsy: A Case Report. ( 28736746 )
2017
21
Rectosigmoid malakoplakia. ( 28566412 )
2017
22
Isolated urachal malakoplakia mimicking malignancy. ( 28216941 )
2017
23
Nonhealing surgical wound due to cutaneous malakoplakia. ( 27935636 )
2017
24
Enteral Malakoplakia Prior to Helicobacter cinaedi Bacteremia. ( 28050043 )
2017
25
Malacoplakia mimicking colonic malignancy: A case report. ( 29446821 )
2017
26
Cutaneous malakoplakia masquerading as pyoderma gangrenosum. ( 27524799 )
2016
27
Malakoplakia of the Urinary Bladder in a Patient with Chronic Lymphocytic Leukemia Under Ibrutinib Therapy: A Case Report. ( 27630324 )
2016
28
A 13-Month-Old With Xanthogranulomatous Pyelonephritis With Features of Renal Malakoplakia. ( 26894199 )
2016
29
Co-existing malakoplakia and xanthogranulomatous pyelonephritis of kidney: Two different spectrum of same disease process. ( 27141206 )
2016
30
Malakoplakia Associated With Multiple Adenomas of the Colon: An Extremely Rare Incidental Finding. ( 26912474 )
2016
31
Renal Parenchymal Malakoplakia Presenting as Acute Renal Failure in a Young Woman. ( 27453243 )
2016
32
AJKD Atlas of Renal Pathology: Malakoplakia. ( 27664482 )
2016
33
A Case of Cutaneous Malakoplakia in the Head and Neck Region and Review of the Literature. ( 27154024 )
2016
34
Malakoplakia associated with prostatic adenocarcinoma: Report of 4 cases and literature review. ( 27180057 )
2016
35
Successful treatment of vaginal malakoplakia in a young cat. ( 28491441 )
2016
36
Coexistence of Malakoplakia and Papillary Urothelial Carcinoma of the Urinary Bladder. ( 26194600 )
2015
37
Malakoplakia of the Pancreas with Simultaneous Colon Involvement: Case Report and Review of the Literature. ( 26090256 )
2015
38
Malakoplakia of the Urogenital Tract. ( 26793484 )
2015
39
A case of pseudotumoral malakoplakia following pathologic complete response in rectal cancer. ( 26136124 )
2015
40
Colorectal malakoplakia in a child presenting as multiple polyposis coli. ( 25673602 )
2015
41
Disseminated Mycobacterium Simiae with Pelvic Malakoplakia in an AIDS Patient. ( 26483613 )
2015
42
Urothelial Carcinoma Concomitant With Malakoplakia In Non-Functioning Nephrolithic Kidneys. ( 26431100 )
2015
43
Renal malakoplakia mimicking a malignant renal carcinoma: a patient case with literature review. ( 26177998 )
2015
44
Malakoplakia of the appendiceal orifice mimicking adenomatous epithelium. ( 25818115 )
2015
45
Uterine malakoplakia diagnosed in a cervical Pap smear. ( 25900733 )
2015
46
Malakoplakia of the Thyroid Gland: A Case Report and Review of Literature. ( 25663335 )
2015
47
An unusual large abdominal malakoplakia following trauma: Diagnosed on FNAC. ( 25694063 )
2015
48
Malakoplakia affecting the umbilical cord. ( 25812742 )
2015
49
Malakoplakia of the prostate masquerading as locally advanced prostate cancer on mpMRI. ( 26834906 )
2015
50
Xanthogranulomatous cystitis with malacoplakia, leading to spontaneous intraperitoneal perforation of the urinary bladder in a 9-year-old girl. ( 26272961 )
2015

Variations for Malakoplakia

Expression for Malakoplakia

Search GEO for disease gene expression data for Malakoplakia.

Pathways for Malakoplakia

GO Terms for Malakoplakia

Sources for Malakoplakia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....