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CM
MCID: MLR004
MIFTS: 80

Malaria (CM)

Categories: Blood diseases, Genetic diseases, Infectious diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Malaria

About this section

MalaCards integrated aliases for Malaria:

Name: Malaria 57 12 74 20 58 54 42 3 44 15 17 71
Malaria, Cerebral, Susceptibility to 57 29 6
Susceptibility to Malaria 29 6 17
Malaria, Resistance to 57 29 6
Malaria, Cerebral 57 44 71
Cerebral Malaria 12 15 17
Malaria, Severe, Susceptibility to 57 6
Malaria, Severe, Resistance to 57 6
Induced Malaria 12 71
Resistance to Malaria Due to G6pd Deficiency 57
Malaria, Vivax, Protection Against 57
Malaria, Cerebral, Reduced Risk of 57
Malaria Due to G6pd Deficiency 57
Malaria, Protection Against 57
Malaria, Susceptibility to 57
Malarial Encephalitis 12
Malaria Cerebral 54
Malaria, Severe 57
Cm 48

Characteristics:

Orphanet epidemiological data:

58
malaria
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Infectious diseases
Anatomical: Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:12365 DOID:14069
OMIM® 57 611162
ICD9CM 34 084
SNOMED-CT 67 154374002 53622003
ICD10 32 B50.0 B53.1 B54
MESH via Orphanet 45 D008288
UMLS via Orphanet 72 C0024530
Orphanet 58 ORPHA673
UMLS 71 C0024530 C0024534 C0153122
Sources

Summaries for Malaria

About this section
OMIM® : 57 Malaria, a major cause of child mortality worldwide, is caused by mosquito-borne hematoprotozoan parasites of the genus Plasmodium. Of the 4 species that infect humans, P. falciparum causes the most severe forms of malaria and is the major cause of death and disease. Although less fatal, P. malariae, P. ovale, and, in particular, P. vivax infections are major causes of morbidity. The parasite cycle involves a first stage in liver cells and a subsequent stage at erythrocytes, when malaria symptoms occur. A wide spectrum of phenotypes are observed, from asymptomatic infection to mild disease, including fever and mild anemia, to severe disease, including cerebral malaria, profound anemia, and respiratory distress. Genetic factors influence the response to infection, as well as disease progression and severity. Malaria is the strongest known selective pressure in the recent history of the human genome, and it is the evolutionary driving force behind sickle-cell disease (603903), thalassemia (see 141800), glucose-6-phosphatase deficiency (300908), and other erythrocyte defects that together constitute the most common mendelian diseases of humans (Kwiatkowski, 2005; Campino et al., 2006). (611162) (Updated 05-Mar-2021)

MalaCards based summary : Malaria, also known as malaria, cerebral, susceptibility to, is related to plasmodium falciparum malaria and plasmodium vivax malaria, and has symptoms including fever, angina pectoris and chest pain. An important gene associated with Malaria is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Azithromycin and Sulfanilamide have been mentioned in the context of this disorder. Affiliated tissues include liver, t cells and brain, and related phenotypes are nausea and vomiting and fever

Disease Ontology : 12 A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.

GARD : 20 Malaria is a serious and sometimes fatal disease caused by a parasite that commonly infects a certain type of mosquito which feeds on humans. Infection with malaria parasites may result in a wide variety of symptoms, ranging from absent or very mild symptoms to severe disease and even death. People who get malaria are typically very sick with high fevers, shaking chills, and flu-like illness. In general, malaria is a curable disease if diagnosed and treated promptly and correctly. Treatment depends on many factors including disease severity, the species of malaria parasite causing the infection and the part of the world in which the infection was acquired.

MedlinePlus : 42 Malaria is a serious disease caused by a parasite. You get it when an infected mosquito bites you. Malaria is a major cause of death worldwide, but it is almost wiped out in the United States. The disease is mostly a problem in developing countries with warm climates. If you travel to these countries, you are at risk. There are four different types of malaria caused by four related parasites. The most deadly type occurs in Africa south of the Sahara Desert. Malaria symptoms include chills, flu-like symptoms, fever, vomiting, diarrhea, and jaundice. A blood test can diagnose it. It can be life-threatening. However, you can treat malaria with drugs. The type of drug depends on which kind of malaria you have and where you were infected. Malaria can be prevented. When traveling to areas where malaria is found See your doctor for medicines that protect you Wear insect repellent with DEET Cover up Sleep under mosquito netting Centers for Disease Control and Prevention

CDC : 3 Malaria is a serious and sometimes fatal disease caused by a parasite that commonly infects a certain type of mosquito which feeds on humans. People who get malaria are typically very sick with high fevers, shaking chills, and flu-like illness. Although malaria can be a deadly disease, illness and death from malaria can usually be prevented.

Wikipedia : 74 Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes... more...

Sources

Related Diseases for Malaria

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Diseases related to Malaria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 988)
# Related Disease Score Top Affiliating Genes
1 plasmodium falciparum malaria 34.3 TNF NOS2 IL10 IFNG ICAM1 HBB
2 plasmodium vivax malaria 33.9 TNF IL10 IFNG ICAM1 G6PD ACKR1
3 glucosephosphate dehydrogenase deficiency 33.0 SLC4A1 HBB G6PD ACKR1
4 disease by infectious agent 32.9 TNF IL10 IFNG FCGR2A
5 dengue disease 32.8 TNF IL10 IFNG ICAM1
6 deficiency anemia 32.6 TNF SLC4A1 LOC106099062 HBB G6PD CR1
7 thrombocytopenia 32.6 TNF IL10 IFNG ICAM1 FCGR2B FCGR2A
8 filariasis 32.3 TNF NOS2 IL10 IFNG
9 hemolytic anemia 32.3 TNF SLC4A1 LOC106099062 IL10 HBB G6PD
10 leishmaniasis 32.2 TNF NOS2 IL10 IFNG FCGR2A
11 sickle cell anemia 32.1 TNF LOC110006319 LOC106099062 IL10 ICAM1 HBB
12 hereditary elliptocytosis 32.1 SLC4A1 HBB GYPC GYPB GYPA G6PD
13 pulmonary edema 32.1 TNF NOS2 IL10 ICAM1
14 trypanosomiasis 32.1 TNF IL10 IFNG ICAM1 HBB
15 thalassemia 32.1 LOC110006319 LOC106099062 HBB
16 sickle cell disease 32.0 LOC110006319 LOC106099062 HBB G6PD
17 pneumonia 32.0 TNF IL10 IFNG ICAM1
18 schistosomiasis 32.0 TNF IL10 IFNG
19 bacterial infectious disease 31.9 TNF IL10 IFNG FCGR2A
20 mycobacterium tuberculosis 1 31.9 TNF IL10 IFNG CISH
21 neutropenia 31.9 TNF IL10 IFNG ACKR1
22 chagas disease 31.8 TNF NOS2 IL10 IFNG
23 hemoglobinopathy 31.8 LOC110006319 LOC106099062 HBB GYPA G6PD
24 alpha-thalassemia 31.8 TNF LOC110006319 LOC106099062 HBB G6PD
25 acquired immunodeficiency syndrome 31.8 TNF NOS2 IL10 IFNG ICAM1
26 meningitis 31.8 TNF IL10 IFNG ICAM1 FCGR2A
27 myocarditis 31.8 TNF NOS2 IL10 IFNG ICAM1
28 autoimmune disease 31.7 TNF IL10 IFNG FCGR2B FCGR2A
29 respiratory failure 31.7 TNF SLC4A1 IL10 ICAM1 G6PD
30 exanthem 31.7 TNF IL10 IFNG
31 parasitic protozoa infectious disease 31.7 TNF IL10 IFNG ICAM1 HBB GYPA
32 hepatitis a 31.7 TNF IL10 IFNG GYPA
33 poliomyelitis 31.7 TNF IL10 IFNG ICAM1 FCGR2A
34 visceral leishmaniasis 31.7 TNF NOS2 IL10 IFNG
35 beta-thalassemia 31.6 SLC4A1 LOC110006319 LOC106099062 HBB G6PD
36 viral hepatitis 31.6 TNF IL10 IFNG G6PD
37 diabetes mellitus 31.6 TNF NOS2 IL10 IFNG ICAM1 HBB
38 dengue hemorrhagic fever 31.6 TNF IL10 IFNG ICAM1 FCGR2B FCGR2A
39 bacterial meningitis 31.6 TNF IL10 IFNG CR1
40 leptospirosis 31.6 TNF IL10 IFNG
41 purpura 31.6 TNF IL10 IFNG
42 toxic shock syndrome 31.6 TNF NOS2 IL10 IFNG
43 proteasome-associated autoinflammatory syndrome 1 31.5 TNF NOS2 IL10 IFNG ICAM1
44 bacterial sepsis 31.5 TNF NOS2 IL10
45 toxoplasmosis 31.5 TNF IL10 IFNG
46 lupus erythematosus 31.5 TNF IL10 IFNG FCGR2B FCGR2A CR1
47 gastroenteritis 31.5 TNF IL10 IFNG
48 amebiasis 31.5 TNF IL10 ICAM1
49 leprosy 3 31.5 TNF IL10 IFNG
50 methemoglobinemia 31.4 LOC106099062 HBB G6PD

Graphical network of the top 20 diseases related to Malaria:



Diseases related to Malaria
Sources

Symptoms & Phenotypes for Malaria

About this section

Human phenotypes related to Malaria:

58 31 (show all 17)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 nausea and vomiting 58 31 hallmark (90%) Very frequent (99-80%) HP:0002017
2 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
3 anemia 58 31 hallmark (90%) Very frequent (99-80%) HP:0001903
4 headache 58 31 hallmark (90%) Very frequent (99-80%) HP:0002315
5 elevated c-reactive protein level 58 31 hallmark (90%) Very frequent (99-80%) HP:0011227
6 acute kidney injury 58 31 hallmark (90%) Very frequent (99-80%) HP:0001919
7 morphological central nervous system abnormality 31 hallmark (90%) HP:0002011
8 reduced consciousness/confusion 58 31 frequent (33%) Frequent (79-30%) HP:0004372
9 cognitive impairment 58 31 frequent (33%) Frequent (79-30%) HP:0100543
10 thrombocytopenia 58 31 frequent (33%) Frequent (79-30%) HP:0001873
11 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
12 gait imbalance 58 31 frequent (33%) Frequent (79-30%) HP:0002141
13 hyperbilirubinemia 58 31 frequent (33%) Frequent (79-30%) HP:0002904
14 respiratory distress 58 31 frequent (33%) Frequent (79-30%) HP:0002098
15 retinopathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0000488
16 morphological abnormality of the central nervous system 58 Very frequent (99-80%)
17 abnormality of blood and blood-forming tissues 58 Frequent (79-30%)

Clinical features from OMIM®:

611162 (Updated 05-Mar-2021)

UMLS symptoms related to Malaria:


fever, angina pectoris, chest pain, pruritus, edema, remittent fever

MGI Mouse Phenotypes related to Malaria:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 CD36 CISH FCGR2A FCGR2B G6PD GYPC
2 homeostasis/metabolism MP:0005376 9.8 ACKR1 CD36 CISH FCGR2A FCGR2B G6PD
3 immune system MP:0005387 9.4 ACKR1 CD36 CISH FCGR2A FCGR2B ICAM1
Sources

Drugs & Therapeutics for Malaria

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Drugs for Malaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 263)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 55185 447043
2
Sulfanilamide Approved Phase 4 63-74-1 5333
3
Quinine Approved Phase 4 130-95-0 8549 3034034
4
Morphine Approved, Investigational Phase 4 57-27-2 5288826
5
Artemether Approved Phase 4 71963-77-4 119380 9796294 68911
6
Lumefantrine Approved Phase 4 82186-77-4 6437380
7
Iron Approved Phase 4 7439-89-6 23925 29936
8
Zinc Approved, Investigational Phase 4 7440-66-6 32051
9
Copper Approved, Investigational Phase 4 7440-50-8 27099
10
Iodine Approved, Investigational Phase 4 7553-56-2 807
11
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 15589840
12
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
13
Tocopherol Approved, Investigational Phase 4 1406-66-2
14
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
15
Promethazine Approved, Investigational Phase 4 60-87-7 4927
16
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
17
Ferrous fumarate Approved Phase 4 141-01-5
18
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
19
Selenium Approved, Investigational, Vet_approved Phase 4 7782-49-2
20
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
21
Lopinavir Approved Phase 4 192725-17-0 92727
22
Permethrin Approved, Investigational Phase 4 52645-53-1 40326
23
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
24
tannic acid Approved Phase 4 1401-55-4
25
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
26
tafenoquine Approved, Investigational Phase 4 106635-80-7 115358
27
Dolutegravir Approved Phase 4 1051375-16-6 54726191
28
Lactitol Approved, Investigational Phase 4 585-86-4 157355
29
Atovaquone Approved Phase 4 95233-18-4 74989
30
Proguanil Approved Phase 4 500-92-5 4923
31
Nevirapine Approved Phase 4 129618-40-2 4463
32
BCG vaccine Approved, Investigational Phase 4
33
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
34
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
35
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
36
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
37
Cadexomer iodine Experimental Phase 4 94820-09-4
38
Cobalamin Experimental Phase 4 13408-78-1 6857388
39 Tocotrienol Investigational Phase 4 6829-55-6
40 Liver Extracts Phase 4
41 Red Cinchona Phase 4
42 Artemisinine Phase 4
43 Artemisinins Phase 4
44 Iron Supplement Phase 4
45 Trace Elements Phase 4
46 Nutrients Phase 4
47 Micronutrients Phase 4
48 Vitamins Phase 4
49 Vitamin B 6 Phase 4
50 Vitamin B 12 Phase 4

Interventional clinical trials:

(show top 50) (show all 1165)
# Name Status NCT ID Phase Drugs
1 The Effect of Paracetamol in the Treatment of Non-severe Malaria in Children in Guinea-Bissau Unknown status NCT00137566 Phase 4 acetaminophen (paracetamol)
2 The Impact of Intermittent Preventive Malaria Treatment With Artemisinin Combination Therapy (ACT) on Hemoglobin, Malaria, Schistosomiasis, and School Attention Among Primary Schoolchildren in the Kassena-Nankana Districts, Ghana Unknown status NCT01459146 Phase 4 Artemether-lumefantrine combination plus albendazole;Artemether-lumefantrine plus Praziquantel plus Albendazole;Albendazole plus Praziquantel
3 An Evaluation of Sulfadoxine-pyrimethamine Resistance and Effectiveness of IPTp in Nigeria Unknown status NCT01636895 Phase 4 Efficacy of suphladoxine/pyrimethamine as IPTp;Efficacy of suphladoxine/pyrimethamine as IPTp
4 Impact of Insecticide Resistance in Anopheles Arabiensis on the Effectiveness of Malaria Vector Control in Sudan Unknown status NCT01713517 Phase 4
5 Efficacy of Artesunate Monotherapy and Dihydroartemisinin - Piperaquine in Patients With Uncomplicated Falciparum Malaria in Central Vietnam Unknown status NCT02604966 Phase 4 Artesunate (AS) group;DHA - PPQ group
6 Programmatic Implementation of ACTs in Malawi: Safety and Effectiveness of Combination Therapies With Repeated Treatments for Uncomplicated P. Falciparum Malaria Over a Three-year Period Unknown status NCT01038063 Phase 4 Artemether-lumefantrine combination
7 Comparing the Effectiveness of 5 Artemisinin Combination Treatment Regimens in the Treatment of Uncomplicated Falciparum Malaria Unknown status NCT00902811 Phase 4 AM(FDC);AM(LT);AL;DP;AA(FDC)
8 An Open Label Randomized Comparison of Two Antimalarial Drugs Regimens in Patient With Plasmodium Vivax Malaria in Thailand Unknown status NCT01662700 Phase 4 Artesunate;Chloroquine
9 Evaluation of the Public Health Impact and Cost Effectiveness of Seasonal Intermittent Preventive Treatment in Children in Senegal Unknown status NCT00712374 Phase 4 sulfadoxine-pyrimethamine plus amodiaquine
10 Confirmation of Artemisinin Tolerance in Malaria Parasites Trial in Kilifi Unknown status NCT01190371 Phase 4 Artesunate
11 Intermittent Treatment With Sulfadoxine-Pyrimethamine for Malaria Control in Children: A Randomised, Double Blind, and Placebo-Controlled Clinical Trial Unknown status NCT00168948 Phase 4 Sulfadoxin (12.5) Pyrimethamine (250 mg)
12 Intravenous Artesunate Versus Quinine in Severe Malaria at Kassla, Sudan Unknown status NCT01805232 Phase 4 artesunate;Quinine
13 Effectiveness of Oral Quinine and Artemether-Lumefantrine in the Treatment of Uncomplicated Malaria in Ugandan Children Unknown status NCT00540202 Phase 4 artemether-lumefantrine;Oral quinine
14 A Randomized, Double Blind Trial on the Efficacy and Safety of Amodiaquine-Artesunate and Amodiaquine Alone in the Treatment of Children With Uncomplicated Falciparum Malaria Unknown status NCT00238017 Phase 4 amodiaquine-artesunate versus amodiaquine
15 Dihydroartemisinin- Piperaquine Versus Artemether- Lumefantrine in the Treatment Uncomplicated Plasmodium Falciparum Malaria in Sudan Unknown status NCT01075945 Phase 4 Dihydroartemisinin- piperaquine;artemether- lumefantrine
16 THE OPTIMAL TIMING OF PRIMAQUINE TO PREVENT MALARIA TRANSMISSION AFTER ARTEMISININ-COMBINATION THERAPY Unknown status NCT01906788 Phase 4 Artemether Lumefantrine;Artemether Lumefantrine 6 dose regimen & single dose of Primaquine on day 0;Artemether Lumefantrine 6 dose regimen and single dose Primaquine on day 2
17 Efficacy and Safety of Artemether + Lumefantrine and Dihydroartemisinin + Piperaquine for the Treatment of Uncomplicated Malaria in Guinea-Bissau. Unknown status NCT01704508 Phase 4 Artemether-lumefantrine;Dihydroartemisinin-piperaquine
18 Cluster Randomised Trial to Compare Effectiveness of the Combined Use of Indoor Residual Spraying (IRS) and Long-lasting Insecticidal Nets (LLINs) to LLINs Alone for Malaria Prevention in Muleba District, Kagera Region, Tanzania Unknown status NCT01697852 Phase 4
19 Artemether/ Lumefantrine: A Study of the Effect of Local Food on Pharmacokinetics of Lumefantrine and Population Pharmacokinetics of Lumefantrine Among Ugandan Children Unknown status NCT01944189 Phase 4
20 Assessment of in Vivo and in Vitro Efficacy of Combined Artesunate/Mefloquine Therapy for Treatment of Uncomplicated Plasmodium Falciparum Infection in the Peruvian Amazon Unknown status NCT02084602 Phase 4 Artesunate;Mefloquine
21 Evaluating the Efficacy of Chloroquine for the Treatment of Plasmodium Vivax Infections in Central Vietnam Unknown status NCT02610686 Phase 4 Chloroquine
22 A Safety, Tolerability, Pharmacokinetic and Efficacy Study of Azithromycin Plus Piperaquine as Presumptive Treatment in Pregnant Papua New Guinean Women Unknown status NCT02575755 Phase 4 Azithromycin plus piperaquine phosphate;Sulfadoxine-pyrimethamine
23 Safety, Tolerability and Pilot Efficacy of Short Course, High Dose Primaquine Treatment for Liver Stages of Plasmodium Vivax Infection Unknown status NCT02364583 Phase 4 Primaquine
24 Evaluation of Impact Dihydroartemisinin-piperaquine Plus Primaquine on Malaria Transmission in Lempasing Village, Lampung Province, Southern Sumatra Completed NCT01389557 Phase 4 Dihydroartemisinin-piperaquine with primaquine
25 A Pilot Study of the Use of Homeopathic-Based Treatment Approaches to Reduce the Prevalence of Malaria in Depressed Communities Completed NCT00351013 Phase 4
26 Assessing and Monitoring the Efficacy of Sulfadoxine/ Pyrimethamine (SP) and the Combination of SP Plus Artesunate for Uncomplicated Malaria Infections Among Children Completed NCT00140361 Phase 4 Sulfadoxine-pyrimethamine;sulfadoxine-pyrimethamine plus artesunate;lumefantrine plus artemether
27 An Evaluation of the Impact of Cotrimoxazole Prophylaxis for HIV-Infected Adults on the Development of Antifolate Resistance Among Plasmodium Falciparum, Streptococcus Pneumoniae, and Escherichia Coli Completed NCT00137657 Phase 4 Cotrimoxazole (trimethoprim sulfamethoxazole)
28 The Efficacy of Re-treatment With Sulfadoxine-pyrimethamine in Children With Recrudescent Malaria in Guinea-Bissau Completed NCT00137553 Phase 4 Sulfadoxine-pyrimethamine (Fansidar)
29 Chloroquine and Amodiaquine for Treatment of Symptomatic Children With Plasmodium Malaria in Guinea-Bissau Completed NCT00137514 Phase 4 chloroquine;amodiaquine
30 Efficacy of Artesunate-amodiaquine, Dihydroartemisinin-piperaquine and Artemether-lumefantrine Combination Therapies for the Treatment of Uncomplicated Plasmodium Falciparum Malaria in Children Aged 6 to 59 Months in Maradi, Niger 2012-13 Completed NCT01755559 Phase 4 Artesunate-amodiaquine;Dihydroartemisinin-piperaquine;Artemether-lumefantrine
31 Effectiveness of Dihydroartemisinin-piperaquine With or Without Primaquine on Gametocytes Plasmodium Falciparum in Mesoendemic Area of Indonesia Completed NCT01392014 Phase 4 dihydroartemisinin-piperaquine;dihydroartemisinin-piperaquine + primaquine
32 A Cluster Randomized, Single-centre, Controlled, Parallel,12-month Prospective Study and Additional 12-month Follow-up in Africa of Malaria Incidence in a Community Setting Following Systematic Treatment of P. Falciparum Asymptomatic Carriers With Artemether-lumefantrine (Coartem® / Coartem® Dispersible) Completed NCT01256658 Phase 4 COA566
33 Efficacy of Intermittent Sulfadoxine-Pyrimethamine and Sulfadoxine-Pyrimethamine + Artesunate Treatment in the Prevention of Malaria in Pregnancy in an Area With Chloroquine-Resistant Plasmodium Falciparum Completed NCT00164255 Phase 4 sulfadoxine/pyrimethamine;sulfadoxine/pyrimethamine plus artesunate
34 Pharmacokinetic Study of Multi-dose Chloroquine Completed NCT01814423 Phase 4 Chloroquine-base 50 mg;Chloroquine-base 70 mg
35 Assessing Chloroquine Resistance of Plasmodium Vivax in Malaria Endemic Area Completed NCT02118090 Phase 4 Chloroquine sulfate;DHA-PP
36 Chloroquine and Coartem for Treatment of Symptomatic Children With Plasmodium Falciparum in Guinea Bissau. Completed NCT00426439 Phase 4 Chloroquine;Artemether-lumefantrine (Coartem)
37 Evaluating the Impact of Enhanced Health Facility-based Care for Malaria and Febrile Illnesses in Children in Tororo, Uganda Completed NCT01024426 Phase 4
38 Community-led Responses for Elimination (CoRE): A Cluster Randomized Controlled Trial of Reactive Case Detection Versus Reactive Drug Administration in Malaria Elimination Areas in Southern Province Zambia Completed NCT02654912 Phase 4 Reactive Focal Drug Administration
39 Parenteral Artesunate Compared to Quinine as a Cause of Late Post-treatment Anaemia in African Children With Hyperparasitaemic P. Falciparum Malaria Completed NCT02092766 Phase 4 artesunate;quinine
40 Estimating the Risk of Plasmodium Vivax Relapses in Afghanistan Completed NCT01178021 Phase 4 Chloroquine;Chloroquine/Primaquine
41 'SCHOOL-BASED TREATMENT WITH ACT TO REDUCE TRANSMISSION' (START-IPT): Evaluation of the Community Impact of Intermittent Preventive Treatment for Malaria in Ugandan Children: a Cluster Randomised Trial Completed NCT02009215 Phase 4 Dihydroartemisinin-piperaquine (DP)
42 Efficacy of Amodiaquine-artesunate in the Treatment of Symptomatic, Uncomplicated Plasmodium Falciparum Malaria Among 6-59 Month Old Children at an IPTi Site in Rural Western Kenya Completed NCT00425763 Phase 4 AQAS
43 Comparison of Two Strategies for the Delivery of Intermittent Preventive Treatment in Children (IPTc) in an Area of Seasonal Malaria Transmission Completed NCT00376155 Phase 4 sulfadoxine /pyrimethamine plus amodiaquine
44 Artemether-Lumefantrine Clinical Effectiveness Study Completed NCT01599000 Phase 4 Artemether-lumefantrine combination
45 Clinical Efficacy of Artemisinin-based Combination Therapy for Treatment of Uncomplicated Plasmodium Falciparum Malaria in North Sumatera, Indonesia and the Association of Molecular Markers With Treatment Outcomes Completed NCT02325180 Phase 4 Dihydroartemisinin-Piperaquine;Artemether-lumefantrine
46 Effects of Restricting the Use of AS-AQ Combination Therapy to Malaria Cases Confirmed by a Dipstick Test: A Cluster Randomised Control Trial Completed NCT00832754 Phase 4
47 Targeting Malaria High-risk Populations With Tailored Intervention Packages: A Study to Assess Feasibility and Effectiveness in Northern Namibia Completed NCT04094727 Phase 4 Presumptive treatment with Artemether-lumefantrine (AL)
48 Pharmacokinetic Interaction Between the Antimalarial Combination Artemether/Lumefantrine and Combination Antiretroviral Therapy Including Nevirapine in HIV-infected Adults Completed NCT00790881 Phase 4 Artemether/Lumefantrine;Artemether/ lumefantrine
49 A Randomised, Open-label Non-inferiority Trial of Artemether-lumefantrine Versus Quinine for the Treatment of Uncomplicated Falciparum Malaria During Pregnancy, Mbarara, Uganda (2006-2007) Completed NCT00495508 Phase 4 Quinine;artemether / lumefantrine
50 An Examination of ACT Strategy in South-central Asia on Falciparum Malaria in a Context Where Vivax is the Major Species Completed NCT00935688 Phase 4

Search NIH Clinical Center for Malaria

Inferred drug relations via UMLS 71 / NDF-RT 51 :


Antimalarial [EPC]
artemether
Atovaquone
Chloroquine
Chloroquine hydrochloride
chloroquine phosphate
Dihydrofolate Reductase Inhibitor Antimalarial [EPC]
halofantrine
Halofantrine hydrochloride
Hydroxychloroquine
Hydroxychloroquine Sulfate
lumefantrine
Mefloquine
Mefloquine Hydrochloride
Pentoxifylline
Primaquine
Primaquine Phosphate
Proguanil
Pyrimethamine
Quinine
QUININE SO4 PWDR
Quinine Sulfate

Cochrane evidence based reviews: malaria

Sources

Genetic Tests for Malaria

About this section

Genetic tests related to Malaria:

# Genetic test Affiliating Genes
1 Susceptibility to Malaria 29 ACKR1 CD36 CISH CR1 FCGR2A FCGR2B G6PD GYPA GYPB GYPC HBB ICAM1 NOS2 SLC4A1 TIRAP TNF
2 Malaria, Resistance to 29
3 Malaria, Cerebral, Susceptibility to 29
Sources

Anatomical Context for Malaria

About this section

MalaCards organs/tissues related to Malaria:

40
Liver, T Cells, Brain, Endothelial, Spleen, Kidney, Whole Blood
Sources

Publications for Malaria

About this section

Articles related to Malaria:

(show top 50) (show all 30704)
# Title Authors PMID Year
1
How malaria has affected the human genome and what human genetics can teach us about malaria. 57 6 61 54
16001361 2005
2
A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus. 57 6 61
20385827 2010
3
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. 57 6 61
17322885 2007
4
Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria. 57 6 61
17435165 2007
5
Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria. 6 57 61
15973412 2005
6
A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria. 6 57 54
14694201 2004
7
A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children. 54 57 6
12433515 2002
8
The association of the glycophorin C exon 3 deletion with ovalocytosis and malaria susceptibility in the Wosera, Papua New Guinea. 6 57 61
11719395 2001
9
A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria. 54 57 6
10369255 1999
10
Absence of an association between intercellular adhesion molecule 1, complement receptor 1 and interleukin 1 receptor antagonist gene polymorphisms and severe malaria in a West African population. 57 6 54
9861406 1998
11
A high frequency African coding polymorphism in the N-terminal domain of ICAM-1 predisposing to cerebral malaria in Kenya. 6 57 54
9259284 1997
12
Sickle hemoglobin confers tolerance to Plasmodium infection. 6 57
21529713 2011
13
Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand. 57 6
20855594 2010
14
FCGR2A functional genetic variant associated with susceptibility to severe malarial anaemia in Ghanaian children. 57 6
19965803 2010
15
Hemoglobin C is associated with reduced Plasmodium falciparum parasitemia and low risk of mild malaria attack. 6 57
14613965 2004
16
Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations. 6 57
12469115 2003
17
Malaria susceptibility and CD36 mutation. 57 6
10890433 2000
18
Polymorphism in promoter region of inducible nitric oxide synthase gene and protection against malaria. 57 6
9457101 1998
19
A 3.5 kb deletion in the glycophorin C gene accounts for the Gerbich-negative blood group in Melanesians. 57 6
8157284 1994
20
The Gerbich blood group system, especially in Melanesians. 57 6
5011657 1972
21
A functional promoter variant in IL12B predisposes to cerebral malaria. 57 61 54
18413324 2008
22
Significant association between TIM1 promoter polymorphisms and protection against cerebral malaria in Thailand. 61 54 57
18294362 2008
23
Genome-wide linkage analysis of malaria infection intensity and mild disease. 57 54 61
17381244 2007
24
The beta -globin recombinational hotspot reduces the effects of strong selection around HbC, a recently arisen mutation providing resistance to malaria. 6 54 61
16175509 2005
25
Early phagocytosis of glucose-6-phosphate dehydrogenase (G6PD)-deficient erythrocytes parasitized by Plasmodium falciparum may explain malaria protection in G6PD deficiency. 57 61 54
9746794 1998
26
Structural basis for RIFIN-mediated activation of LILRB1 in malaria. 61 57
32650338 2020
27
Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk. 61 57
29599243 2018
28
Malaria parasites target the hepatocyte receptor EphA2 for successful host infection. 57 61
26612952 2015
29
A novel locus of resistance to severe malaria in a region of ancient balancing selection. 61 57
26416757 2015
30
Malaria. A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion. 61 57
25954012 2015
31
Reappraisal of known malaria resistance loci in a large multicenter study. 57 61
25261933 2014
32
Patterns of nucleotide and haplotype diversity at ICAM-1 across global human populations with varying levels of malaria exposure. 6 61
23609612 2013
33
Severe malaria is associated with parasite binding to endothelial protein C receptor. 57 61
23739325 2013
34
Cytoadherence in paediatric malaria: ABO blood group, CD36, and ICAM1 expression and severe Plasmodium falciparum infection. 61 57
22909232 2012
35
Genome-wide association study indicates two novel resistance loci for severe malaria. 57 61
22895189 2012
36
Interaction of malaria with a common form of severe thalassemia in an Asian population. 61 6
19841268 2009
37
A variant in the gene FUT9 is associated with susceptibility to placental malaria infection. 57 61
19460885 2009
38
Association of the GNAS locus with severe malaria. 61 57
18951142 2008
39
Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants. 57 61
17668374 2007
40
CD36 polymorphism is associated with protection from cerebral malaria. 57 54
12506336 2003
41
Susceptibility to malaria as a complex trait: big pressure from a tiny creature. 57 61
12351583 2002
42
Hemoglobin E: a balanced polymorphism protective against high parasitemias and thus severe P falciparum malaria. 6 61
12149194 2002
43
Hemoglobin C associated with protection from severe malaria in the Dogon of Mali, a West African population with a low prevalence of hemoglobin S. 61 6
11001883 2000
44
The immunogenetics of resistance to malaria. 6 61
10417733 1999
45
Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria. 57 54
7617034 1995
46
Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria. 54 57
7935762 1994
47
Common west African HLA antigens are associated with protection from severe malaria. 57 54
1865923 1991
48
Malaria and red cell genetic defects. 61 57
2669996 1989
49
Severe malaria and glucose-6-phosphate-dehydrogenase deficiency: a reappraisal of the malaria/G-6-P.D. hypothesis. 61 57
85108 1979
50
Malaria and COVID-19: unmasking their ties. 42 61
33357220 2020
Sources

Variations for Malaria

About this section

ClinVar genetic disease variations for Malaria:

6 (show all 41)
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 FCGR2B NM_004001.4(FCGR2B):c.695T>C (p.Ile232Thr) SNV protective 5467 rs1050501 1:161643798-161643798 1:161674008-161674008
2 CR1 CR1, 3650A-G SNV protective 17066
3 NOS2 NOS2A, -969G-C SNV protective 14014
4 NOS2 NG_011470.1:g.3828C>T SNV protective 14013 17:26128728-26128728 17:27801702-27801702
5 TIRAP NM_148910.2(TIRAP):c.539C>T (p.Ser180Leu) SNV protective 4467 rs8177374 11:126162843-126162843 11:126292948-126292948
6 GYPC NM_002101.4(GYPC):c.107_190del (p.Glu36_Ala63del) Deletion protective 17725 2:127451437-127451520 2:126693861-126693944
7 CISH NM_001243926.1(MAPKAPK3):c.-436A>T SNV Affects 7091 rs414171 3:50649499-50649499 3:50612068-50612068
8 LOC106099062 NM_000518.4(HBB):c.19G>A (p.Glu7Lys) SNV protective 15126 rs33930165 11:5248233-5248233 11:5227003-5227003
9 LOC106099062 NM_000518.5(HBB):c.79G>A (p.Glu27Lys) SNV protective 15161 rs33950507 11:5248173-5248173 11:5226943-5226943
10 LOC106099062 NM_000518.5(HBB):c.20A>T (p.Glu7Val) SNV protective 15333 rs334 11:5248232-5248232 11:5227002-5227002
11 G6PD NM_000402.4(G6PD):c.653C>T (p.Ser218Phe) SNV Pathogenic 100057 rs5030868 X:153762634-153762634 X:154534419-154534419
12 G6PD NM_000402.4(G6PD):c.466A>G (p.Asn156Asp) SNV Pathogenic 100055 rs1050829 X:153763492-153763492 X:154535277-154535277
13 LOC106099062 NM_000518.5(HBB):c.20A>T (p.Glu7Val) SNV Pathogenic 15333 rs334 11:5248232-5248232 11:5227002-5227002
14 G6PD NM_000402.4(G6PD):c.1478G>A (p.Arg493His) SNV Pathogenic 100059 rs72554664 X:153760472-153760472 X:154532257-154532257
15 G6PD NM_000402.4(G6PD):c.1093G>A (p.Ala365Thr) SNV Pathogenic 10363 rs5030869 X:153761205-153761205 X:154532990-154532990
16 G6PD NM_000402.4(G6PD):c.961G>A (p.Val321Met) SNV Pathogenic 10386 rs137852327 X:153761337-153761337 X:154533122-154533122
17 G6PD NM_000402.4(G6PD):c.934G>C (p.Asp312His) SNV Pathogenic 10372 rs137852318 X:153761811-153761811 X:154533596-154533596
18 LOC106099062 NM_000518.5(HBB):c.118C>T (p.Gln40Ter) SNV Pathogenic 15402 rs11549407 11:5248004-5248004 11:5226774-5226774
19 LOC106099062 NM_000518.5(HBB):c.93-21G>A SNV Pathogenic 15454 rs35004220 11:5248050-5248050 11:5226820-5226820
20 LOC106099062 NM_000518.5(HBB):c.92+6T>C SNV Pathogenic 15450 rs35724775 11:5248154-5248154 11:5226924-5226924
21 LOC106099062 NM_000518.5(HBB):c.92+5G>C SNV Pathogenic 15447 rs33915217 11:5248155-5248155 11:5226925-5226925
22 HBB NM_000518.5(HBB):c.-79A>G SNV Pathogenic 15469 rs34598529 11:5248330-5248330 11:5227100-5227100
23 LOC110006319 NM_000518.5(HBB):c.316-106C>G SNV Pathogenic 15457 rs34690599 11:5247062-5247062 11:5225832-5225832
24 LOC106099062 NM_000518.5(HBB):c.315+1G>A SNV Pathogenic 15438 rs33945777 11:5247806-5247806 11:5226576-5226576
25 LOC106099062 NM_000518.5(HBB):c.92+1G>A SNV Pathogenic 15436 rs33971440 11:5248159-5248159 11:5226929-5226929
26 LOC106099062 NM_000518.5(HBB):c.52A>T (p.Lys18Ter) SNV Pathogenic 15401 rs33986703 11:5248200-5248200 11:5226970-5226970
27 HBB NM_000518.5(HBB):c.-137C>A SNV Pathogenic 36285 rs33941377 11:5248388-5248388 11:5227158-5227158
28 SLC4A1 NM_000342.4(SLC4A1):c.1765C>T (p.Arg589Cys) SNV Pathogenic 17764 rs121912745 17:42333076-42333076 17:44255708-44255708
29 G6PD NM_000402.4(G6PD):c.577G>A (p.Gly193Ser) SNV Pathogenic 10367 rs137852314 X:153762710-153762710 X:154534495-154534495
30 FCGR2A NM_001136219.3(FCGR2A):c.500A>G (p.His167Arg) SNV risk factor 14823 rs1801274 1:161479745-161479745 1:161509955-161509955
31 HBB NM_000518.5(HBB):c.-138C>A SNV Likely pathogenic 393701 rs33944208 11:5248389-5248389 11:5227159-5227159
32 CD36 NM_001001547.3(CD36):c.975T>G (p.Tyr325Ter) SNV risk factor 13536 rs3211938 7:80300449-80300449 7:80671133-80671133
33 TNF TNF, -376G-A SNV risk factor 12387
34 ICAM1 NM_000201.3(ICAM1):c.167A>T (p.Lys56Met) SNV risk factor 14661 rs5491 19:10385540-10385540 19:10274864-10274864
35 CD36 NM_001001547.3(CD36):c.1254+1G>A SNV Likely pathogenic 417926 rs148051111 7:80302726-80302726 7:80673410-80673410
36 CD36 NM_001001547.3(CD36):c.784dup (p.Gln262fs) Duplication Likely pathogenic 587500 rs766920034 7:80299302-80299303 7:80669986-80669987
37 TNF TNF, -308G-A SNV risk factor 12388
38 CD36 CD36, G1439C, 1-BP DEL, 1444A Deletion risk factor 13537
39 CD36 NM_001001547.3(CD36):c.429+2T>C SNV Likely pathogenic 417962 rs3211893 7:80290528-80290528 7:80661212-80661212
40 ICAM1 NM_000201.3(ICAM1):c.1432C>T (p.Arg478Trp) SNV Uncertain significance 828004 rs5030400 19:10395796-10395796 19:10285120-10285120
41 CD36 NM_001001547.3(CD36):c.701_701+3dup Duplication Likely benign 417963 rs1554343345 7:80293811-80293812 7:80664495-80664496

Copy number variations for Malaria from CNVD:

7 (show all 17)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 16026 1 12212699 12494685 Indels VPS13D Malaria
2 31007 1 247110827 247119907 Amplification ZNF692 Malaria
3 34945 1 5845456 5975118 Indels NPHP4 Malaria
4 41121 4 135333667 135338574 Indels DUX4 Malaria
5 61463 12 1 132349534 Indels Malaria
6 64882 12 132073128 132099226 Indels ZNF26 Malaria
7 82377 14 105461656 105464413 Indels FAM30A Malaria
8 143470 2 237000000 242951149 Indels Malaria
9 166350 3 10158318 10168746 Indels VHL Malaria
10 177623 3 59710075 61212173 Indels FHIT Malaria
11 191457 5 1 180857866 Indels Malaria
12 192407 5 112071116 112209835 Indels APC Malaria
13 203647 6 1 170899992 Indels Malaria
14 217046 7 1 158821424 Indels Malaria
15 227212 7 65675806 65694798 Indels Malaria
16 230732 8 1 146274826 Indels Malaria
17 243826 8 8897723 8928259 Indels ERI1 Malaria
Sources

Expression for Malaria

About this section
LifeMap Discovery
Genes differentially expressed in tissues of Malaria patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 MMP9 matrix metallopeptidase 9 Blood + 3.31 0.000
2 C1QB complement C1q B chain Blood + 3.10 0.000
Search GEO for disease gene expression data for Malaria.
Sources

Pathways for Malaria

About this section

Pathways related to Malaria according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.96 TNF TIRAP NOS2 IL10 IFNG ICAM1
2
Cytokine Signaling in Immune system 65
Show member pathways
 13.29 TNF NOS2 IL10 IFNG ICAM1 CISH
3
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 12.98 TNF TIRAP NOS2 IL10 IFNG CISH
4
Folate Metabolism 1
Show member pathways
 12.25 TNF IFNG ICAM1 HBB
5
Toll Comparative Pathway 63
Show member pathways
 12.24 TNF TIRAP NOS2 IFNG
6
Bacterial infections in CF airways 23
Show member pathways
 12.12 TNF TIRAP NOS2 IFNG
7
Toxoplasmosis 36
Show member pathways
 12.12 TNF NOS2 IL10 IFNG FCGR2A CR1
8
Tuberculosis 36
12.01 TNF TIRAP NOS2 IL10 IFNG FCGR2B
9
Osteoclast differentiation 36
11.97 TNF IFNG FCGR2B FCGR2A
10
Spinal Cord Injury 1
11.91 TNF NOS2 IFNG ICAM1 FCGR2A
11
Interleukin-4 and 13 signaling 65
11.86 TNF NOS2 IL10 ICAM1 CD36
12
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.86 TNF IL10 IFNG GYPA FCGR2A CD36
13
Amoebiasis 36
11.85 TNF NOS2 IL10 IFNG
14
Hematopoietic cell lineage 36
11.82 TNF GYPA CR1 CD36
15
Rheumatoid arthritis 36
11.79 TNF IFNG ICAM1
16
Staphylococcus aureus infection 36
11.79 IL10 ICAM1 FCGR2B FCGR2A
17
Innate Lymphoid Cell Differentiation Pathways 64
11.72 TNF IL10 IFNG
18
Th1 Differentiation Pathway 64
Show member pathways
 11.68 TNF IL10 IFNG
19
Pertussis 36
11.68 TNF TIRAP NOS2 IL10
20
Dendritic Cells Developmental Lineage Pathway 64
11.67 TNF IL10 IFNG
21
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.56 TNF NOS2 IFNG ICAM1
22
Interleukin-10 signaling 65
11.47 TNF IL10 ICAM1
23
MSP-RON Signaling 63
11.45 TNF NOS2 IFNG
24
IgA-Producing B Cells in the Intestine 64
11.38 TNF NOS2 IL10 ICAM1 FCGR2B FCGR2A
25
Type II interferon signaling (IFNG) 1
11.32 NOS2 IFNG ICAM1
26
IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
Show member pathways
 11.3 TNF IL10 IFNG
27
African trypanosomiasis 36
11.22 TNF IL10 IFNG ICAM1 HBB
28
Cytokines and Inflammatory Response 1
11.19 TNF IL10 IFNG
29
Malaria 36
11.06 TNF IL10 IFNG ICAM1 HBB GYPC
30
LDL Oxidation in Atherogenesis 63
10.86 TNF ICAM1 CD36
Sources

GO Terms for Malaria

About this section

Cellular components related to Malaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10 TNF TIRAP SLC4A1 NOS2 ICAM1 GYPC
2 integral component of plasma membrane GO:0005887 9.32 TNF SLC4A1 ICAM1 GYPC GYPB GYPA
3 cortical cytoskeleton GO:0030863 9.13 SLC4A1 NOS2 GYPC

Biological processes related to Malaria according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 10.04 TNF IL10 IFNG FCGR2B CD36
2 inflammatory response GO:0006954 9.99 TNF TIRAP NOS2 FCGR2B ACKR1
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.91 TNF TIRAP ICAM1 CD36
4 cell surface receptor signaling pathway GO:0007166 9.88 TIRAP IFNG FCGR2B FCGR2A CD36
5 response to lipopolysaccharide GO:0032496 9.85 TIRAP NOS2 IL10 ICAM1
6 cytokine-mediated signaling pathway GO:0019221 9.85 TNF NOS2 IL10 ICAM1 CD36
7 viral entry into host cell GO:0046718 9.84 ICAM1 GYPA CR1
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.84 TNF TIRAP ICAM1 CD36
9 positive regulation of tumor necrosis factor production GO:0032760 9.83 TIRAP IFNG CD36
10 positive regulation of JNK cascade GO:0046330 9.83 TNF TIRAP FCGR2B
11 regulation of insulin secretion GO:0050796 9.8 TNF NOS2 IFNG
12 positive regulation of protein complex assembly GO:0031334 9.76 TNF TIRAP IFNG
13 positive regulation of cytokine production GO:0001819 9.75 TNF IL10 IFNG
14 cellular response to amyloid-beta GO:1904646 9.7 ICAM1 FCGR2B CD36
15 positive regulation of phagocytosis GO:0050766 9.69 TNF IFNG FCGR2B
16 positive regulation of interleukin-12 production GO:0032735 9.67 TIRAP IFNG CD36
17 positive regulation of signaling receptor activity GO:2000273 9.66 IL10 IFNG
18 negative regulation of amyloid-beta clearance GO:1900222 9.65 TNF IFNG
19 positive regulation of MHC class II biosynthetic process GO:0045348 9.64 IL10 IFNG
20 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.63 TNF TIRAP
21 cellular response to lipoteichoic acid GO:0071223 9.63 TIRAP CD36
22 negative regulation of immunoglobulin production GO:0002638 9.62 FCGR2B CR1
23 endothelial cell apoptotic process GO:0072577 9.61 TNF IL10
24 cellular response to bacterial lipopeptide GO:0071221 9.6 TIRAP CD36
25 positive regulation of killing of cells of other organism GO:0051712 9.57 NOS2 IFNG
26 negative regulation of cytokine production involved in immune response GO:0002719 9.56 TNF IL10
27 positive regulation of interleukin-6 production GO:0032755 9.56 TNF TIRAP IFNG CD36
28 leukocyte migration GO:0050900 9.55 TNF ICAM1 GYPC GYPB GYPA
29 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 TNF IFNG
30 positive regulation of blood microparticle formation GO:2000334 9.4 TNF CD36
31 positive regulation of vitamin D biosynthetic process GO:0060557 9.37 TNF IFNG
32 cellular response to lipopolysaccharide GO:0071222 9.35 TNF NOS2 IL10 ICAM1 CD36
33 positive regulation of nitrogen compound metabolic process GO:0051173 9.32 TNF IFNG
34 positive regulation of nitric oxide biosynthetic process GO:0045429 9.02 TNF IFNG ICAM1 HBB CD36

Molecular functions related to Malaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.56 ICAM1 FCGR2B FCGR2A ACKR1
2 IgG binding GO:0019864 9.16 FCGR2B FCGR2A
3 virus receptor activity GO:0001618 9.13 ICAM1 GYPA CR1
4 hemoglobin binding GO:0030492 8.62 SLC4A1 HBB
Sources

Sources for Malaria

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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