MCID: MLR005
MIFTS: 23

Male Reproductive Organ Benign Neoplasm

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Male Reproductive Organ Benign Neoplasm

MalaCards integrated aliases for Male Reproductive Organ Benign Neoplasm:

Name: Male Reproductive Organ Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060087

Summaries for Male Reproductive Organ Benign Neoplasm

Disease Ontology : 12 A reproductive organ benign neoplasm that is characterized by a lack of malignancy located in the male reproductive system.

MalaCards based summary : Male Reproductive Organ Benign Neoplasm is related to prostatic adenoma and prostate leiomyoma. An important gene associated with Male Reproductive Organ Benign Neoplasm is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. Affiliated tissues include male reproductive system, and related phenotypes are Decreased substrate adherent cell growth and muscle

Related Diseases for Male Reproductive Organ Benign Neoplasm

Diseases related to Male Reproductive Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
# Related Disease Score Top Affiliating Genes
1 prostatic adenoma 28.9 SERPINA3 KLK3 CLIP3 ADRB3 ADRB2 ADRB1
2 prostate leiomyoma 11.4
3 epididymis adenomatoid tumor 11.4
4 ureterolithiasis 10.2 ADRA1D ADRA1A
5 urethral stricture 10.2 KLK3 ADRA1D
6 autoimmune cardiomyopathy 10.1 LCOR ADRB1
7 prostatic hyperplasia, benign 10.1 SERPINA3 KLK3
8 prostate calculus 10.1 KLK3 CLIP3
9 horner's syndrome 10.0 ADRA2A ADRA1A
10 meningococcal infection 10.0 ADRB2 ADRB1
11 perinephritis 10.0 ADRA2C ADRA2B ADRA1B ADRA1A
12 prostatic hypertrophy 10.0 SERPINA3 KLK3 ADRA1D ADRA1A
13 reflex sympathetic dystrophy 9.9 ADRA2C ADRA2B ADRA1B ADRA1A
14 resting heart rate, variation in 9.9 ADRB2 ADRB1 ADRA2B
15 impotence 9.8 KLK3 ADRA2C ADRA1D ADRA1B ADRA1A
16 ocular hypotension 9.7 ADRB2 ADRB1 ADRA2C ADRA1B
17 causalgia 9.7 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A
18 coronary artery vasospasm 9.5 ADRA2C ADRA2B ADRA2A ADRA1D ADRA1B ADRA1A
19 orthostatic intolerance 9.5 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
20 congestive heart failure 9.4 ADRB2 ADRB1 ADRA2C
21 seminal vesicle tumor 9.3 OGFRL1 KLK3 CCDC115 C4orf47
22 attention deficit-hyperactivity disorder 9.2 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1A
23 body mass index quantitative trait locus 11 9.2 SERPINA3 LCOR ADRB3 ADRB2 ADRB1 ADRA2A
24 dilated cardiomyopathy 9.2 SERPINA3 ADRB3 ADRB2 ADRB1 ADRA2C ADRA1D
25 asthma 9.1 SERPINA3 KLK3 ADRB3 ADRB2 ADRB1 ADRA1B
26 sexual disorder 8.8 KLK3 ADRB3 ADRB1 ADRA2C ADRA2B ADRA2A
27 agnosia 8.6 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
28 pain agnosia 8.6 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
29 hypertension, essential 8.5 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A

Graphical network of the top 20 diseases related to Male Reproductive Organ Benign Neoplasm:



Diseases related to Male Reproductive Organ Benign Neoplasm

Symptoms & Phenotypes for Male Reproductive Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 8.92 ADRA1A ADRA1B ADRA1D ADRA2B

MGI Mouse Phenotypes related to Male Reproductive Organ Benign Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.17 ADRA1A ADRA1B ADRA1D ADRA2B ADRB1 ADRB2

Drugs & Therapeutics for Male Reproductive Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Male Reproductive Organ Benign Neoplasm

Genetic Tests for Male Reproductive Organ Benign Neoplasm

Anatomical Context for Male Reproductive Organ Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Male Reproductive Organ Benign Neoplasm:

19
Male Reproductive System

Publications for Male Reproductive Organ Benign Neoplasm

Variations for Male Reproductive Organ Benign Neoplasm

Expression for Male Reproductive Organ Benign Neoplasm

Search GEO for disease gene expression data for Male Reproductive Organ Benign Neoplasm.

Pathways for Male Reproductive Organ Benign Neoplasm

Pathways related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 KLK3 CLIP3 ADRB3 ADRB2 ADRB1 ADRA2C
2
Show member pathways
13.41 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
3
Show member pathways
13.36 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
4
Show member pathways
12.71 ADRB2 ADRB1 ADRA2B ADRA2A ADRA1B ADRA1A
5
Show member pathways
12.37 ADRB3 ADRB2 ADRB1 ADRA1D ADRA1B ADRA1A
6
Show member pathways
12.35 ADRB2 ADRA2C ADRA2B ADRA2A
7
Show member pathways
12.31 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
8
Show member pathways
12.14 ADRB3 ADRB2 ADRB1 ADRA1D ADRA1B ADRA1A
9
Show member pathways
12.03 ADRA2C ADRA2B ADRA2A ADRA1D ADRA1B ADRA1A
10
Show member pathways
11.95 ADRB3 ADRB2 ADRB1 ADRA1D ADRA1B ADRA1A
11 11.92 ADRB3 ADRB2 ADRB1
12
Show member pathways
11.83 ADRA1D ADRA1B ADRA1A
13
Show member pathways
11.7 ADRA2C ADRA2B ADRA2A
14 11.54 ADRB3 ADRB2 ADRB1
15 11.48 ADRB2 ADRB1 ADRA2A ADRA1D
16 11.43 ADRB3 ADRB2 ADRB1
17
Show member pathways
11.32 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
18 10.92 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1D

GO Terms for Male Reproductive Organ Benign Neoplasm

Cellular components related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.07 SLITRK2 OGFRL1 CLIP3 CCDC115 ADRB3 ADRB2
2 plasma membrane GO:0005886 9.9 SLITRK2 CLIP3 ADRB3 ADRB2 ADRB1 ADRA2C
3 integral component of plasma membrane GO:0005887 9.28 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
4 integral component of postsynaptic membrane GO:0099055 9.13 SLITRK2 ADRA2C ADRA1A

Biological processes related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.25 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
2 G protein-coupled receptor signaling pathway GO:0007186 10.16 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
3 cell-cell signaling GO:0007267 9.93 ADRA2C ADRA2B ADRA1D ADRA1B ADRA1A
4 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.86 ADRB3 ADRB2 ADRB1 ADRA2A
5 positive regulation of cytosolic calcium ion concentration GO:0007204 9.83 ADRA1D ADRA1B ADRA1A
6 platelet activation GO:0030168 9.81 ADRA2C ADRA2B ADRA2A
7 positive regulation of cold-induced thermogenesis GO:0120162 9.81 ADRB3 ADRB2 ADRB1
8 positive regulation of vasoconstriction GO:0045907 9.8 ADRA2C ADRA1D ADRA1B ADRA1A
9 positive regulation of MAPK cascade GO:0043410 9.8 ADRB3 ADRB2 ADRA2C ADRA2B ADRA2A ADRA1B
10 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.79 ADRA1D ADRA1B ADRA1A
11 activation of adenylate cyclase activity GO:0007190 9.79 ADRB3 ADRB2 ADRB1
12 activation of protein kinase B activity GO:0032148 9.77 ADRA2C ADRA2B ADRA2A
13 adrenergic receptor signaling pathway GO:0071875 9.76 ADRB3 ADRB2 ADRA2C ADRA2B ADRA2A ADRA1D
14 positive regulation of smooth muscle contraction GO:0045987 9.72 ADRA1D ADRA1B ADRA1A
15 regulation of vasoconstriction GO:0019229 9.72 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A
16 negative regulation of norepinephrine secretion GO:0010700 9.7 ADRA2C ADRA2B ADRA2A
17 regulation of smooth muscle contraction GO:0006940 9.67 ADRB2 ADRA2C ADRA2B ADRA2A
18 brown fat cell differentiation GO:0050873 9.65 ADRB2 ADRB1
19 regulation of cardiac muscle contraction GO:0055117 9.65 ADRA1B ADRA1A
20 receptor transactivation GO:0035624 9.65 ADRA2C ADRA2B ADRA2A
21 regulation of muscle contraction GO:0006937 9.64 ADRA1B ADRA1A
22 negative regulation of multicellular organism growth GO:0040015 9.63 ADRB2 ADRB1
23 negative regulation of epinephrine secretion GO:0032811 9.63 ADRA2C ADRA2B ADRA2A
24 diet induced thermogenesis GO:0002024 9.62 ADRB2 ADRB1
25 desensitization of G protein-coupled receptor signaling pathway by arrestin GO:0002032 9.61 ADRB3 ADRB2
26 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure GO:0001994 9.61 ADRA1D ADRA1B ADRA1A
27 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.61 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
28 heat generation GO:0031649 9.58 ADRB2 ADRB1
29 positive regulation of the force of heart contraction by epinephrine-norepinephrine GO:0001997 9.58 ADRB1 ADRA1A
30 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure GO:0002025 9.58 ADRB3 ADRB2 ADRB1
31 positive regulation of heart rate by epinephrine-norepinephrine GO:0001996 9.57 ADRB1 ADRA1A
32 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.28 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A

Molecular functions related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.97 ADRB3 ADRB2 ADRB1 ADRA2B ADRA2A ADRA1D
2 protein heterodimerization activity GO:0046982 9.85 ADRB1 ADRA2C ADRA2A ADRA1B ADRA1A
3 alpha2-adrenergic receptor activity GO:0004938 9.5 ADRA2C ADRA2B ADRA2A
4 norepinephrine binding GO:0051380 9.46 ADRB3 ADRB2 ADRB1 ADRA2A
5 alpha-2A adrenergic receptor binding GO:0031694 9.43 ADRB1 ADRA2C
6 alpha1-adrenergic receptor activity GO:0004937 9.43 ADRA1D ADRA1B ADRA1A
7 epinephrine binding GO:0051379 9.43 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
8 beta-adrenergic receptor activity GO:0004939 9.4 ADRB3 ADRB1
9 adrenergic receptor activity GO:0004935 9.28 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A

Sources for Male Reproductive Organ Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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