MCID: MLR005
MIFTS: 25

Male Reproductive Organ Benign Neoplasm

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Male Reproductive Organ Benign Neoplasm

MalaCards integrated aliases for Male Reproductive Organ Benign Neoplasm:

Name: Male Reproductive Organ Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060087

Summaries for Male Reproductive Organ Benign Neoplasm

MalaCards based summary : Male Reproductive Organ Benign Neoplasm is related to rete testis adenocarcinoma and kidney sarcoma. An important gene associated with Male Reproductive Organ Benign Neoplasm is DICER1 (Dicer 1, Ribonuclease III), and among its related pathways/superpathways are Melanocyte Development and Pigmentation and Ovarian Infertility Genes. Affiliated tissues include kidney, ovary and prostate, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Male Reproductive Organ Benign Neoplasm

Diseases in the Male Reproductive Organ Cancer family:

Male Reproductive Organ Benign Neoplasm

Diseases related to Male Reproductive Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 rete testis adenocarcinoma 10.2 AFP KLK3
2 kidney sarcoma 10.2 DICER1 WT1
3 dysgerminoma 10.2 AFP WT1
4 bladder neck obstruction 10.2 AFP KLK3
5 maligant granulosa cell tumor of the ovary 10.2 DICER1 FOXL2
6 cystic nephroma 10.2 DICER1 WT1
7 gynandroblastoma 10.2 DICER1 FOXL2
8 endodermal sinus tumor 10.2 AFP KLK3
9 rete testis neoplasm 10.2 AFP KLK3
10 corpus luteum cyst 10.2 AFP FOXL2
11 adenomatoid tumor 10.2 AFP WT1
12 kidney benign neoplasm 10.2 DICER1 WT1
13 46,xy partial gonadal dysgenesis 10.2 NR5A1 WT1
14 nephrotic syndrome, type 1 10.2 AFP WT1
15 urethral diverticulum 10.2 KLK3 WT1
16 central nervous system primitive neuroectodermal neoplasm 10.2 DICER1 SYP
17 malignant sertoli cell tumor 10.2 AFP SYP
18 ovarian cyst 10.2 AFP FOXL2
19 pineal gland cancer 10.2 DICER1 SYP
20 endometrial small cell carcinoma 10.2 AFP SYP
21 malignant teratoma 10.1 AFP SYP
22 prostatic acinar adenocarcinoma 10.1 KLK3 WT1
23 cloacal exstrophy 10.1 AFP NR5A1
24 small cell carcinoma 10.1 KLK3 SYP
25 mediastinal cancer 10.1 AFP SYP
26 pancreatoblastoma 10.1 AFP SYP
27 pulmonary blastoma 10.1 DICER1 SYP
28 prostate small cell carcinoma 10.1 KLK3 SYP
29 atypical choroid plexus papilloma 10.1 DICER1 SYP
30 peritoneal serous adenocarcinoma 10.1 SYP WT1
31 denys-drash syndrome 10.1 NR5A1 WT1
32 cauda equina neoplasm 10.1 SYP WT1
33 ovarian small cell carcinoma 10.1 SYP WT1
34 central nervous system germ cell tumor 10.1 AFP POMC
35 granulosa cell tumor of the ovary 10.1 FOXL2 SYP
36 venous hemangioma 10.1 SYP WT1
37 prostate adenoid cystic carcinoma 10.1 KLK3 POMC
38 androgenic alopecia 10.1 CYP19A1 KLK3
39 spermatocele 10.1 NR5A1 SYP
40 rhabdoid cancer 10.1 SYP WT1
41 desmoplastic small round cell tumor 10.1 SYP WT1
42 mixed cell type cancer 10.1 AFP SYP
43 sertoli-leydig cell tumor 10.1 AFP DICER1 WT1
44 dysgerminoma of ovary 10.1 AFP DICER1 WT1
45 ovarian mucinous neoplasm 10.1 SYP WT1
46 testicular disease 10.1 AFP DICER1
47 tubular adenocarcinoma 10.1 AFP SYP
48 prostatic hypertrophy 10.1 CYP19A1 KLK3
49 gonadoblastoma 10.1 FOXL2 WT1
50 adrenal cortical hypofunction 10.1 NR5A1 POMC

Graphical network of the top 20 diseases related to Male Reproductive Organ Benign Neoplasm:



Diseases related to Male Reproductive Organ Benign Neoplasm

Symptoms & Phenotypes for Male Reproductive Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.32 AFP FOXL2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.32 AFP PRKAR1A
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.32 AFP PRKAR1A
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.32 AFP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.32 AFP FOXL2 PRKAR1A

MGI Mouse Phenotypes related to Male Reproductive Organ Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.98 AFP CYP19A1 DICER1 NR5A1 POMC PRKAR1A
2 endocrine/exocrine gland MP:0005379 9.97 AFP CYP19A1 DICER1 FOXL2 NR5A1 POMC
3 homeostasis/metabolism MP:0005376 9.92 AFP CYP19A1 DICER1 FOXL2 NR5A1 POMC
4 cardiovascular system MP:0005385 9.88 CYP19A1 DICER1 NR5A1 POMC PRKAR1A WT1
5 liver/biliary system MP:0005370 9.73 AFP CYP19A1 DICER1 POMC PRKAR1A WT1
6 neoplasm MP:0002006 9.55 AFP DICER1 POMC PRKAR1A WT1
7 normal MP:0002873 9.5 CYP19A1 DICER1 FOXL2 NR5A1 PRKAR1A SYP
8 reproductive system MP:0005389 9.17 AFP CYP19A1 DICER1 FOXL2 NR5A1 PRKAR1A

Drugs & Therapeutics for Male Reproductive Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Male Reproductive Organ Benign Neoplasm

Genetic Tests for Male Reproductive Organ Benign Neoplasm

Anatomical Context for Male Reproductive Organ Benign Neoplasm

MalaCards organs/tissues related to Male Reproductive Organ Benign Neoplasm:

41
Kidney, Ovary, Prostate, Cervix, Testis, Cortex, Adrenal Gland

Publications for Male Reproductive Organ Benign Neoplasm

Variations for Male Reproductive Organ Benign Neoplasm

Expression for Male Reproductive Organ Benign Neoplasm

Search GEO for disease gene expression data for Male Reproductive Organ Benign Neoplasm.

Pathways for Male Reproductive Organ Benign Neoplasm

Pathways related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.57 POMC PRKAR1A
2 10.13 CYP19A1 NR5A1

GO Terms for Male Reproductive Organ Benign Neoplasm

Biological processes related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tissue development GO:0009888 9.43 NR5A1 WT1
2 adrenal gland development GO:0030325 9.4 NR5A1 WT1
3 uterus development GO:0060065 9.37 CYP19A1 FOXL2
4 apoptotic DNA fragmentation GO:0006309 9.32 DICER1 FOXL2
5 positive regulation of male gonad development GO:2000020 9.26 NR5A1 WT1
6 sex determination GO:0007530 9.16 NR5A1 WT1
7 negative regulation of female gonad development GO:2000195 8.96 NR5A1 WT1
8 female gonad development GO:0008585 8.8 CYP19A1 FOXL2 NR5A1

Sources for Male Reproductive Organ Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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