MCID: MLR005
MIFTS: 18

Male Reproductive Organ Benign Neoplasm

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Male Reproductive Organ Benign Neoplasm

MalaCards integrated aliases for Male Reproductive Organ Benign Neoplasm:

Name: Male Reproductive Organ Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060087

Summaries for Male Reproductive Organ Benign Neoplasm

Disease Ontology : 12 A reproductive organ benign neoplasm that is characterized by a lack of malignancy located in the male reproductive system.

MalaCards based summary : Male Reproductive Organ Benign Neoplasm is related to prostate leiomyoma and prostatic adenoma. An important gene associated with Male Reproductive Organ Benign Neoplasm is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways are TP53 Network and Inhibition of Ribosome Biogenesis by p14(ARF). Affiliated tissues include male reproductive system.

Related Diseases for Male Reproductive Organ Benign Neoplasm

Diseases related to Male Reproductive Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 prostate leiomyoma 32.1 KLK3 AR
2 prostatic adenoma 31.2 SERPINA3 PAM16 MED25 KLK3 CAND2 AR
3 rete testis adenoma 11.3
4 epididymis adenomatoid tumor 11.3
5 male urethral cancer 10.3 KLK3 CDKN2A
6 pancreas sarcoma 10.3 SERPINA3 CDKN2A
7 urethra clear cell adenocarcinoma 10.2 KLK3 CDKN2A
8 undifferentiated embryonal sarcoma of the liver 10.2 TP53 SERPINA3
9 embryonal sarcoma 10.2 TP53 SERPINA3
10 bladder sarcoma 10.2 SERPINA3 KLK3
11 tenosynovial giant cell tumor 10.2 SERPINA3 CDKN2A
12 xanthogranulomatous cholecystitis 10.2 TP53 SERPINA3
13 breast malignant phyllodes tumor 10.2 TP53 SERPINA3
14 malignant spindle cell melanoma 10.2 SERPINA3 CDKN2A
15 urethral benign neoplasm 10.2 TP53 KLK3
16 intrahepatic bile duct adenoma 10.2 TP53 KLK3
17 vulvar intraepithelial neoplasia 10.1 TP53 CDKN2A
18 esophagus verrucous carcinoma 10.1 TP53 CDKN2A
19 ovarian seromucinous carcinoma 10.1 TP53 CDKN2A
20 human papillomavirus infectious disease 10.1 TP53 CDKN2A
21 spitz nevus 10.1 TP53 CDKN2A
22 squamous cell papilloma 10.1 TP53 CDKN2A
23 bizarre leiomyoma 10.1 TP53 CDKN2A
24 prostatitis 10.1 TP53 SERPINA3 KLK3
25 adult malignant schwannoma 10.1 TP53 CDKN2A
26 supraglottis cancer 10.1 TP53 CDKN2A
27 suppressor of tumorigenicity 3 10.1 TP53 CDKN2A
28 localized osteosarcoma 10.1 TP53 CDKN2A
29 malignant exocrine pancreas neoplasm 10.1 TP53 CDKN2A
30 chronic cervicitis 10.1 TP53 CDKN2A
31 thyroid lymphoma 10.1 TP53 CDKN2A
32 bladder clear cell adenocarcinoma 10.1 TP53 CDKN2A
33 keratinizing squamous cell carcinoma 10.1 TP53 CDKN2A
34 prostate adenoid cystic carcinoma 10.1 KLK3 AR
35 malignant spiradenoma 10.1 TP53 CDKN2A
36 bile duct adenoma 10.1 TP53 CDKN2A
37 vulva squamous cell carcinoma 10.1 TP53 CDKN2A
38 prostate calculus 10.1 KLK3 AR
39 nodular prostate 10.1 KLK3 AR
40 vaginal cancer 10.1 TP53 CDKN2A
41 bronchiectasis 3 10.1 KLK3 AR
42 nasal cavity adenocarcinoma 10.1 TP53 CDKN2A
43 prostatic acinar adenocarcinoma 10.1 KLK3 AR
44 bone squamous cell carcinoma 10.0 TP53 CDKN2A
45 low-grade astrocytoma 10.0 TP53 CDKN2A
46 gliofibroma 10.0 TP53 CDKN2A
47 nasal cavity cancer 10.0 TP53 CDKN2A
48 prostate squamous cell carcinoma 10.0 TP53 CDKN2A
49 prostate neuroendocrine neoplasm 10.0 KLK3 AR
50 prostate transitional cell carcinoma 10.0 KLK3 AR

Graphical network of the top 20 diseases related to Male Reproductive Organ Benign Neoplasm:



Diseases related to Male Reproductive Organ Benign Neoplasm

Symptoms & Phenotypes for Male Reproductive Organ Benign Neoplasm

Drugs & Therapeutics for Male Reproductive Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Male Reproductive Organ Benign Neoplasm

Genetic Tests for Male Reproductive Organ Benign Neoplasm

Anatomical Context for Male Reproductive Organ Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Male Reproductive Organ Benign Neoplasm:

19
Male Reproductive System

Publications for Male Reproductive Organ Benign Neoplasm

Variations for Male Reproductive Organ Benign Neoplasm

Expression for Male Reproductive Organ Benign Neoplasm

Search GEO for disease gene expression data for Male Reproductive Organ Benign Neoplasm.

Pathways for Male Reproductive Organ Benign Neoplasm

Pathways related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.3 TP53 CDKN2A
2 9.97 TP53 CDKN2A

GO Terms for Male Reproductive Organ Benign Neoplasm

Cellular components related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.02 AR CDKN2A KLK3 PAM16 TP53

Biological processes related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 replicative senescence GO:0090399 9.16 CDKN2A TP53
2 regulation of systemic arterial blood pressure GO:0003073 8.96 AR KLK3
3 positive regulation of cell cycle arrest GO:0071158 8.8 CDKN2A MED25 TP53

Molecular functions related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.26 TP53 MED25 CDKN2A AR
2 MDM2/MDM4 family protein binding GO:0097371 8.62 TP53 CDKN2A

Sources for Male Reproductive Organ Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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