Male Reproductive Organ Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Male Reproductive Organ Benign Neoplasm

MalaCards integrated aliases for Male Reproductive Organ Benign Neoplasm:

Name: Male Reproductive Organ Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060087

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Summaries for Male Reproductive Organ Benign Neoplasm

MalaCards based summary : Male Reproductive Organ Benign Neoplasm is related to rete testis adenocarcinoma and kidney sarcoma. An important gene associated with Male Reproductive Organ Benign Neoplasm is DICER1 (Dicer 1, Ribonuclease III), and among its related pathways/superpathways are Melanocyte Development and Pigmentation and Ovarian Infertility Genes. Affiliated tissues include kidney, ovary and prostate, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Male Reproductive Organ Benign Neoplasm

Diseases in the Male Reproductive Organ Cancer family:

Male Reproductive Organ Benign Neoplasm

Diseases related to Male Reproductive Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)

#	Related Disease	Score	Top Affiliating Genes
1	rete testis adenocarcinoma	10.2	AFP KLK3
2	kidney sarcoma	10.2	DICER1 WT1
3	dysgerminoma	10.2	AFP WT1
4	bladder neck obstruction	10.2	AFP KLK3
5	maligant granulosa cell tumor of the ovary	10.2	DICER1 FOXL2
6	cystic nephroma	10.2	DICER1 WT1
7	gynandroblastoma	10.2	DICER1 FOXL2
8	endodermal sinus tumor	10.2	AFP KLK3
9	rete testis neoplasm	10.2	AFP KLK3
10	corpus luteum cyst	10.2	AFP FOXL2
11	adenomatoid tumor	10.2	AFP WT1
12	kidney benign neoplasm	10.2	DICER1 WT1
13	46,xy partial gonadal dysgenesis	10.2	NR5A1 WT1
14	nephrotic syndrome, type 1	10.2	AFP WT1
15	urethral diverticulum	10.2	KLK3 WT1
16	central nervous system primitive neuroectodermal neoplasm	10.2	DICER1 SYP
17	malignant sertoli cell tumor	10.2	AFP SYP
18	ovarian cyst	10.2	AFP FOXL2
19	pineal gland cancer	10.2	DICER1 SYP
20	endometrial small cell carcinoma	10.2	AFP SYP
21	malignant teratoma	10.1	AFP SYP
22	prostatic acinar adenocarcinoma	10.1	KLK3 WT1
23	cloacal exstrophy	10.1	AFP NR5A1
24	small cell carcinoma	10.1	KLK3 SYP
25	mediastinal cancer	10.1	AFP SYP
26	pancreatoblastoma	10.1	AFP SYP
27	pulmonary blastoma	10.1	DICER1 SYP
28	prostate small cell carcinoma	10.1	KLK3 SYP
29	atypical choroid plexus papilloma	10.1	DICER1 SYP
30	peritoneal serous adenocarcinoma	10.1	SYP WT1
31	denys-drash syndrome	10.1	NR5A1 WT1
32	cauda equina neoplasm	10.1	SYP WT1
33	ovarian small cell carcinoma	10.1	SYP WT1
34	central nervous system germ cell tumor	10.1	AFP POMC
35	granulosa cell tumor of the ovary	10.1	FOXL2 SYP
36	venous hemangioma	10.1	SYP WT1
37	prostate adenoid cystic carcinoma	10.1	KLK3 POMC
38	androgenic alopecia	10.1	CYP19A1 KLK3
39	spermatocele	10.1	NR5A1 SYP
40	rhabdoid cancer	10.1	SYP WT1
41	desmoplastic small round cell tumor	10.1	SYP WT1
42	mixed cell type cancer	10.1	AFP SYP
43	sertoli-leydig cell tumor	10.1	AFP DICER1 WT1
44	dysgerminoma of ovary	10.1	AFP DICER1 WT1
45	ovarian mucinous neoplasm	10.1	SYP WT1
46	testicular disease	10.1	AFP DICER1
47	tubular adenocarcinoma	10.1	AFP SYP
48	prostatic hypertrophy	10.1	CYP19A1 KLK3
49	gonadoblastoma	10.1	FOXL2 WT1
50	adrenal cortical hypofunction	10.1	NR5A1 POMC

Graphical network of the top 20 diseases related to Male Reproductive Organ Benign Neoplasm:

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Symptoms & Phenotypes for Male Reproductive Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-117	9.32	AFP FOXL2
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-48	9.32	AFP PRKAR1A
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-65	9.32	AFP PRKAR1A
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-75	9.32	AFP
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-89	9.32	AFP FOXL2 PRKAR1A

MGI Mouse Phenotypes related to Male Reproductive Organ Benign Neoplasm:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.98	AFP CYP19A1 DICER1 NR5A1 POMC PRKAR1A
2	endocrine/exocrine gland	MP:0005379	9.97	AFP CYP19A1 DICER1 FOXL2 NR5A1 POMC
3	homeostasis/metabolism	MP:0005376	9.92	AFP CYP19A1 DICER1 FOXL2 NR5A1 POMC
4	cardiovascular system	MP:0005385	9.88	CYP19A1 DICER1 NR5A1 POMC PRKAR1A WT1
5	liver/biliary system	MP:0005370	9.73	AFP CYP19A1 DICER1 POMC PRKAR1A WT1
6	neoplasm	MP:0002006	9.55	AFP DICER1 POMC PRKAR1A WT1
7	normal	MP:0002873	9.5	CYP19A1 DICER1 FOXL2 NR5A1 PRKAR1A SYP
8	reproductive system	MP:0005389	9.17	AFP CYP19A1 DICER1 FOXL2 NR5A1 PRKAR1A

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Drugs & Therapeutics for Male Reproductive Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Male Reproductive Organ Benign Neoplasm

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Genetic Tests for Male Reproductive Organ Benign Neoplasm

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Anatomical Context for Male Reproductive Organ Benign Neoplasm

MalaCards organs/tissues related to Male Reproductive Organ Benign Neoplasm:

⁴¹

Kidney, Ovary, Prostate, Cervix, Testis, Cortex, Adrenal Gland

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Publications for Male Reproductive Organ Benign Neoplasm

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Genes for Male Reproductive Organ Benign Neoplasm

Genes related to Male Reproductive Organ Benign Neoplasm (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	DICER1	Dicer 1, Ribonuclease III	Protein Coding	17.09	DISEASES inferred ¹⁵
2	AFP	Alpha Fetoprotein	Protein Coding	16.11	DISEASES inferred ¹⁵
3	KLK3	Kallikrein Related Peptidase 3	Protein Coding	15.63	DISEASES inferred ¹⁵
4	NR5A1	Nuclear Receptor Subfamily 5 Group A Member 1	Protein Coding	15.62	DISEASES inferred ¹⁵
5	WT1	Wilms Tumor 1	Protein Coding	15.27	DISEASES inferred ¹⁵
6	FOXL2	Forkhead Box L2	Protein Coding	15.22	DISEASES inferred ¹⁵
7	SYP	Synaptophysin	Protein Coding	15.21	DISEASES inferred ¹⁵
8	POMC	Proopiomelanocortin	Protein Coding	15.19	DISEASES inferred ¹⁵
9	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	15.07	DISEASES inferred ¹⁵
10	CYP19A1	Cytochrome P450 Family 19 Subfamily A Member 1	Protein Coding	14.93	DISEASES inferred ¹⁵

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Variations for Male Reproductive Organ Benign Neoplasm

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Expression for Male Reproductive Organ Benign Neoplasm

Search GEO for disease gene expression data for Male Reproductive Organ Benign Neoplasm.

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Pathways for Male Reproductive Organ Benign Neoplasm

Pathways related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Melanocyte Development and Pigmentation ⁶⁴	10.57	POMC PRKAR1A
2	Ovarian Infertility Genes ¹	10.13	CYP19A1 NR5A1

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GO Terms for Male Reproductive Organ Benign Neoplasm

Biological processes related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	tissue development	GO:0009888	9.43	NR5A1 WT1
2	adrenal gland development	GO:0030325	9.4	NR5A1 WT1
3	uterus development	GO:0060065	9.37	CYP19A1 FOXL2
4	apoptotic DNA fragmentation	GO:0006309	9.32	DICER1 FOXL2
5	positive regulation of male gonad development	GO:2000020	9.26	NR5A1 WT1
6	sex determination	GO:0007530	9.16	NR5A1 WT1
7	negative regulation of female gonad development	GO:2000195	8.96	NR5A1 WT1
8	female gonad development	GO:0008585	8.8	CYP19A1 FOXL2 NR5A1

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Sources for Male Reproductive Organ Benign Neoplasm

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