Male Reproductive Organ Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Male Reproductive Organ Benign Neoplasm

MalaCards integrated aliases for Male Reproductive Organ Benign Neoplasm:

Name: Male Reproductive Organ Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060087

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Summaries for Male Reproductive Organ Benign Neoplasm

Disease Ontology : ¹² A reproductive organ benign neoplasm that is characterized by a lack of malignancy located in the male reproductive system.

MalaCards based summary : Male Reproductive Organ Benign Neoplasm is related to prostatic adenoma and prostate leiomyoma. An important gene associated with Male Reproductive Organ Benign Neoplasm is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. Affiliated tissues include male reproductive system, and related phenotypes are Decreased substrate adherent cell growth and behavior/neurological

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Related Diseases for Male Reproductive Organ Benign Neoplasm

Diseases related to Male Reproductive Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)

#	Related Disease	Score	Top Affiliating Genes
1	prostatic adenoma	29.2	SERPINA3 KLK3 CLIP3 ADRB3 ADRB2 ADRB1
2	prostate leiomyoma	11.4
3	rete testis adenoma	11.4
4	epididymis adenomatoid tumor	11.4
5	ureterolithiasis	10.3	ADRA1D ADRA1A
6	prostatic hyperplasia, benign	10.3	SERPINA3 KLK3
7	urethral stricture	10.3	KLK3 ADRA1D
8	prostatitis	10.2	SERPINA3 KLK3 ADRA1A
9	male urethral cancer	10.2	KLK3 CDKN2A
10	horner's syndrome	10.2	ADRA2A ADRA1A
11	prostate calculus	10.2	KLK3 CLIP3
12	raynaud disease	10.1	ADRA2C ADRA2B
13	tenosynovial giant cell tumor	10.1	SERPINA3 CDKN2A
14	dopamine beta-hydroxylase deficiency	10.1	ADRA2B ADRA2A ADRA1D
15	meningococcal infection	10.1	ADRB2 ADRB1
16	malignant spindle cell melanoma	10.1	SERPINA3 CDKN2A
17	specific developmental disorder	10.1	SERPINA3 ADRA2C ADRA2A
18	fibrosarcoma of bone	10.1	SERPINA3 CDKN2A
19	perinephritis	10.0	ADRA2C ADRA2B ADRA1B ADRA1A
20	causalgia	10.0	ADRA2C ADRA2B ADRA1B ADRA1A
21	impotence	10.0	KLK3 ADRA1D ADRA1B ADRA1A
22	coronary restenosis	10.0	CDKN2A ADRA2B
23	resting heart rate, variation in	10.0	ADRB2 ADRB1 ADRA2B
24	intraocular pressure quantitative trait locus	9.9	SERPINA3 ADRB2 ADRB1
25	cystitis	9.9	ADRB3 ADRB2 ADRA1D
26	pleomorphic liposarcoma	9.8	SERPINA3 CDKN2A
27	penile benign neoplasm	9.7	SLITRK2 CDKN2A
28	reflex sympathetic dystrophy	9.7	ADRB2 ADRA2C ADRA2B ADRA1B ADRA1A
29	seminal vesicle tumor	9.5	OGFRL1 KLK3 CCDC115 C4orf47
30	orthostatic intolerance	9.5	ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
31	suppression of tumorigenicity 12	9.5	SERPINA3 KLK3 CDKN2A
32	asthma	9.3	SERPINA3 KLK3 ADRB3 ADRB2 ADRB1 ADRA1B
33	attention deficit-hyperactivity disorder	9.3	ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1A
34	dilated cardiomyopathy	9.3	SERPINA3 ADRB3 ADRB2 ADRB1 ADRA2C ADRA1D
35	pheochromocytoma	9.3	CDKN2A ADRB3 ADRB2 ADRA2C
36	prostatic hypertrophy	9.3	SERPINA3 KLK3 ADRA2C ADRA2B ADRA2A ADRA1D
37	sexual disorder	9.3	SERPINA3 KLK3 ADRA2C ADRA2B ADRA2A ADRA1D
38	ocular hypotension	9.2	ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1B
39	coronary artery vasospasm	9.2	ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1B
40	agnosia	8.8	ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
41	pain agnosia	8.8	ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
42	hypertension, essential	8.6	SERPINA3 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B

Graphical network of the top 20 diseases related to Male Reproductive Organ Benign Neoplasm:

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Symptoms & Phenotypes for Male Reproductive Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased substrate adherent cell growth	GR00193-A-1	8.92	ADRA1A ADRA1B ADRA1D ADRA2B

MGI Mouse Phenotypes related to Male Reproductive Organ Benign Neoplasm:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10	ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C
2	cardiovascular system	MP:0005385	9.85	ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C
3	homeostasis/metabolism	MP:0005376	9.7	ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C ADRB1
4	muscle	MP:0005369	9.28	ADRA1A ADRA1B ADRA1D ADRA2B ADRB1 ADRB2

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Drugs & Therapeutics for Male Reproductive Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Male Reproductive Organ Benign Neoplasm

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Genetic Tests for Male Reproductive Organ Benign Neoplasm

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Anatomical Context for Male Reproductive Organ Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Male Reproductive Organ Benign Neoplasm:

¹⁹

Male Reproductive System

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Publications for Male Reproductive Organ Benign Neoplasm

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Genes for Male Reproductive Organ Benign Neoplasm

Genes related to Male Reproductive Organ Benign Neoplasm (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SERPINA3	Serpin Family A Member 3	Protein Coding	7.66	DISEASES inferred ¹⁵ ¹⁵
2	KLK3	Kallikrein Related Peptidase 3	Protein Coding	7.48	DISEASES inferred ¹⁵
3	ADRA1B	Adrenoceptor Alpha 1B	Protein Coding	6.08	DISEASES inferred ¹⁵
4	ADRA1A	Adrenoceptor Alpha 1A	Protein Coding	6.07	DISEASES inferred ¹⁵
5	ADRA2B	Adrenoceptor Alpha 2B	Protein Coding	6.06	DISEASES inferred ¹⁵
6	ADRA2C	Adrenoceptor Alpha 2C	Protein Coding	6.05	DISEASES inferred ¹⁵
7	ADRA1D	Adrenoceptor Alpha 1D	Protein Coding	6.02	DISEASES inferred ¹⁵
8	ADRA2A	Adrenoceptor Alpha 2A	Protein Coding	5.96	DISEASES inferred ¹⁵
9	ADRB3	Adrenoceptor Beta 3	Protein Coding	5.76	DISEASES inferred ¹⁵
10	ADRB1	Adrenoceptor Beta 1	Protein Coding	5.75	DISEASES inferred ¹⁵
11	OGFRL1	Opioid Growth Factor Receptor Like 1	Protein Coding	5.6	DISEASES inferred ¹⁵
12	CCDC115	Coiled-Coil Domain Containing 115	Protein Coding	5.59	DISEASES inferred ¹⁵
13	ADRB2	Adrenoceptor Beta 2	Protein Coding	5.45	DISEASES inferred ¹⁵
14	CLIP3	CAP-Gly Domain Containing Linker Protein 3	Protein Coding	5.39	DISEASES inferred ¹⁵
15	C4orf47	Chromosome 4 Open Reading Frame 47	Protein Coding	5.29	DISEASES inferred ¹⁵
16	SLITRK2	SLIT And NTRK Like Family Member 2	Protein Coding	5.29	DISEASES inferred ¹⁵
17	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	5.13	DISEASES inferred ¹⁵

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Variations for Male Reproductive Organ Benign Neoplasm

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Expression for Male Reproductive Organ Benign Neoplasm

Search GEO for disease gene expression data for Male Reproductive Organ Benign Neoplasm.

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Pathways for Male Reproductive Organ Benign Neoplasm

Pathways related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 18)

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by GPCR ⁶⁵ Show member pathways GPCR downstream signaling ⁶⁵ Signal Transduction ⁶⁵	13.98	KLK3 CLIP3 ADRB3 ADRB2 ADRB1 ADRA2C
2	Peptide ligand-binding receptors ⁶⁵ Show member pathways Class A/1 (Rhodopsin-like receptors) ⁶⁵ Defective AVP causes neurohypophyseal diabetes insipidus (NDI) ⁶⁵ Formyl peptide receptors bind formyl peptides and many other ligands ⁶⁵ G alpha (i) signalling events ⁶⁵ GPCR ligand binding ⁶⁵ GPCRs, Class A Rhodopsin-like ¹ Neuroactive ligand-receptor interaction ³⁶ Orexin and neuropeptides FF and QRFP bind to their respective receptors ⁶⁵ Peptide GPCRs ¹ Tachykinin receptors bind tachykinins ⁶⁵ Vasopressin-like receptors ⁶⁵	13.41	ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
3	Activation of cAMP-Dependent PKA ⁶³ Show member pathways Activation of PKA through GPCR ⁶³ cAMP Pathway ⁶³ PKA Signaling ⁶³	13.36	ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
4	NFAT and Cardiac Hypertrophy ⁶³ Show member pathways IGF1R Signaling ⁶³ Signaling Involved in Cardiac Hypertrophy ⁶³	12.71	ADRB2 ADRB1 ADRA2B ADRA2A ADRA1B ADRA1A
5	Myometrial Relaxation and Contraction Pathways ¹ Show member pathways Calcium Regulation in the Cardiac Cell ¹	12.37	ADRB3 ADRB2 ADRB1 ADRA1D ADRA1B ADRA1A
6	ADP signalling through P2Y purinoceptor 12 ⁶⁵ Show member pathways Adrenaline,noradrenaline inhibits insulin secretion ⁶⁵ Beta-agonist/Beta-blocker Pathway, Pharmacodynamics ⁶⁰ Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding ⁶⁵ G alpha (z) signalling events ⁶⁵ G-protein activation ⁶⁵ Signal transduction cAMP signaling ²²	12.36	ADRB2 ADRA2C ADRA2B ADRA2A
7	cGMP-PKG signaling pathway ³⁶ Show member pathways Adrenergic signaling in cardiomyocytes ³⁶	12.31	ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
8	Calcium signaling pathway ³⁶ Show member pathways Oxytocin signaling ¹	12.15	ADRB3 ADRB2 ADRB1 ADRA1D ADRA1B ADRA1A
9	AMPK Enzyme Complex Pathway ⁶³ Show member pathways Chromatin Remodeling ⁶³ mitochondrial L-carnitine shuttle ¹	12.03	ADRA2C ADRA2B ADRA2A ADRA1D ADRA1B ADRA1A
10	Salivary secretion ³⁶ Show member pathways Gastric acid secretion ³⁶	11.96	ADRB3 ADRB2 ADRB1 ADRA1D ADRA1B ADRA1A
11	G alpha (s) signalling events ⁶⁵	11.92	ADRB3 ADRB2 ADRB1
12	Translation Translation regulation by Alpha-1 adrenergic receptors ²² Show member pathways Development Activation of ERK by Alpha-1 adrenergic receptors ²²	11.83	ADRA1D ADRA1B ADRA1A
13	Integrin alphaIIb beta3 signaling ⁶⁵ Show member pathways GRB2-SOS provides linkage to MAPK signaling for Integrins ⁶⁵ p130Cas linkage to MAPK signaling for integrins ⁶⁵ Platelet Aggregation (Plug Formation) ⁶⁵	11.7	ADRA2C ADRA2B ADRA2A
14	Renin secretion ³⁶	11.54	ADRB3 ADRB2 ADRB1
15	Antiarrhythmic Pathway, Pharmacodynamics ⁶⁰	11.48	ADRB2 ADRB1 ADRA2A ADRA1D
16	Regulation of lipolysis in adipocytes ³⁶	11.43	ADRB3 ADRB2 ADRB1
17	Monoamine GPCRs ¹ Show member pathways Adrenaline signalling through Alpha-2 adrenergic receptor ⁶⁵ Adrenoceptors ⁶⁵ Amine ligand-binding receptors ⁶⁵ Histamine receptors ⁶⁵ Muscarinic acetylcholine receptors ⁶⁵ Serotonin receptors ⁶⁵	11.32	ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
18	Sympathetic Nerve Pathway (Neuroeffector Junction) ⁶⁰	10.92	ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1D

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GO Terms for Male Reproductive Organ Benign Neoplasm

Cellular components related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	9.9	SLITRK2 CLIP3 ADRB3 ADRB2 ADRB1 ADRA2C
2	integral component of plasma membrane	GO:0005887	9.28	ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
3	integral component of postsynaptic membrane	GO:0099055	9.13	SLITRK2 ADRA2C ADRA1A

Biological processes related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 32)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.25	ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
2	G protein-coupled receptor signaling pathway	GO:0007186	10.19	ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
3	cell-cell signaling	GO:0007267	9.97	ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
4	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO:0007189	9.88	ADRB3 ADRB2 ADRB1 ADRA2A
5	positive regulation of MAPK cascade	GO:0043410	9.86	ADRB3 ADRB2 ADRA2C ADRA2B ADRA2A ADRA1D
6	positive regulation of cytosolic calcium ion concentration	GO:0007204	9.83	ADRA1D ADRA1B ADRA1A
7	positive regulation of vasoconstriction	GO:0045907	9.83	ADRA2C ADRA1D ADRA1B ADRA1A
8	platelet activation	GO:0030168	9.81	ADRA2C ADRA2B ADRA2A
9	positive regulation of cold-induced thermogenesis	GO:0120162	9.81	ADRB3 ADRB2 ADRB1
10	regulation of vasoconstriction	GO:0019229	9.8	ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A
11	phospholipase C-activating G protein-coupled receptor signaling pathway	GO:0007200	9.79	ADRA1D ADRA1B ADRA1A
12	activation of adenylate cyclase activity	GO:0007190	9.79	ADRB3 ADRB2 ADRB1
13	activation of protein kinase B activity	GO:0032148	9.77	ADRA2C ADRA2B ADRA2A
14	adrenergic receptor signaling pathway	GO:0071875	9.76	ADRB3 ADRB2 ADRA2C ADRA2B ADRA2A ADRA1D
15	positive regulation of smooth muscle contraction	GO:0045987	9.73	ADRA1D ADRA1B ADRA1A
16	regulation of smooth muscle contraction	GO:0006940	9.73	ADRB2 ADRA2C ADRA2B ADRA2A
17	negative regulation of norepinephrine secretion	GO:0010700	9.72	ADRA2C ADRA2B ADRA2A
18	receptor transactivation	GO:0035624	9.69	ADRA2C ADRA2B ADRA2A
19	negative regulation of epinephrine secretion	GO:0032811	9.67	ADRA2C ADRA2B ADRA2A
20	positive regulation of heart rate by epinephrine-norepinephrine	GO:0001996	9.67	ADRB1 ADRA1D ADRA1B ADRA1A
21	temperature homeostasis	GO:0001659	9.65	ADRB3 ADRB1
22	regulation of cardiac muscle contraction	GO:0055117	9.65	ADRA1B ADRA1A
23	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	GO:0001994	9.65	ADRA1D ADRA1B ADRA1A
24	regulation of muscle contraction	GO:0006937	9.64	ADRA1B ADRA1A
25	negative regulation of multicellular organism growth	GO:0040015	9.63	ADRB2 ADRB1
26	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	GO:0002025	9.63	ADRB3 ADRB2 ADRB1
27	diet induced thermogenesis	GO:0002024	9.62	ADRB2 ADRB1
28	desensitization of G protein-coupled receptor signaling pathway by arrestin	GO:0002032	9.61	ADRB3 ADRB2
29	adenylate cyclase-activating adrenergic receptor signaling pathway	GO:0071880	9.61	ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
30	heat generation	GO:0031649	9.58	ADRB2 ADRB1
31	positive regulation of the force of heart contraction by epinephrine-norepinephrine	GO:0001997	9.57	ADRB1 ADRA1A
32	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	GO:0007188	9.28	ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A

Molecular functions related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	G protein-coupled receptor activity	GO:0004930	9.91	ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
2	protein heterodimerization activity	GO:0046982	9.83	ADRB1 ADRA2C ADRA2A ADRA1B ADRA1A
3	alpha2-adrenergic receptor activity	GO:0004938	9.54	ADRA2C ADRA2B ADRA2A
4	alpha1-adrenergic receptor activity	GO:0004937	9.5	ADRA1D ADRA1B ADRA1A
5	alpha-2A adrenergic receptor binding	GO:0031694	9.46	ADRB1 ADRA2C
6	norepinephrine binding	GO:0051380	9.46	ADRB3 ADRB2 ADRB1 ADRA2A
7	epinephrine binding	GO:0051379	9.43	ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
8	beta-adrenergic receptor activity	GO:0004939	9.4	ADRB3 ADRB1
9	adrenergic receptor activity	GO:0004935	9.28	ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A

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Sources for Male Reproductive Organ Benign Neoplasm

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