MCID: MLR005
MIFTS: 24

Male Reproductive Organ Benign Neoplasm

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Male Reproductive Organ Benign Neoplasm

MalaCards integrated aliases for Male Reproductive Organ Benign Neoplasm:

Name: Male Reproductive Organ Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060087

Summaries for Male Reproductive Organ Benign Neoplasm

Disease Ontology : 12 A reproductive organ benign neoplasm that is characterized by a lack of malignancy located in the male reproductive system.

MalaCards based summary : Male Reproductive Organ Benign Neoplasm is related to prostatic adenoma and prostate leiomyoma. An important gene associated with Male Reproductive Organ Benign Neoplasm is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. Affiliated tissues include male reproductive system, and related phenotypes are Decreased substrate adherent cell growth and behavior/neurological

Related Diseases for Male Reproductive Organ Benign Neoplasm

Diseases related to Male Reproductive Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 prostatic adenoma 29.2 SERPINA3 KLK3 CLIP3 ADRB3 ADRB2 ADRB1
2 prostate leiomyoma 11.4
3 rete testis adenoma 11.4
4 epididymis adenomatoid tumor 11.4
5 ureterolithiasis 10.3 ADRA1D ADRA1A
6 prostatic hyperplasia, benign 10.3 SERPINA3 KLK3
7 urethral stricture 10.3 KLK3 ADRA1D
8 prostatitis 10.2 SERPINA3 KLK3 ADRA1A
9 male urethral cancer 10.2 KLK3 CDKN2A
10 horner's syndrome 10.2 ADRA2A ADRA1A
11 prostate calculus 10.2 KLK3 CLIP3
12 raynaud disease 10.1 ADRA2C ADRA2B
13 tenosynovial giant cell tumor 10.1 SERPINA3 CDKN2A
14 dopamine beta-hydroxylase deficiency 10.1 ADRA2B ADRA2A ADRA1D
15 meningococcal infection 10.1 ADRB2 ADRB1
16 malignant spindle cell melanoma 10.1 SERPINA3 CDKN2A
17 specific developmental disorder 10.1 SERPINA3 ADRA2C ADRA2A
18 fibrosarcoma of bone 10.1 SERPINA3 CDKN2A
19 perinephritis 10.0 ADRA2C ADRA2B ADRA1B ADRA1A
20 causalgia 10.0 ADRA2C ADRA2B ADRA1B ADRA1A
21 impotence 10.0 KLK3 ADRA1D ADRA1B ADRA1A
22 coronary restenosis 10.0 CDKN2A ADRA2B
23 resting heart rate, variation in 10.0 ADRB2 ADRB1 ADRA2B
24 intraocular pressure quantitative trait locus 9.9 SERPINA3 ADRB2 ADRB1
25 cystitis 9.9 ADRB3 ADRB2 ADRA1D
26 pleomorphic liposarcoma 9.8 SERPINA3 CDKN2A
27 penile benign neoplasm 9.7 SLITRK2 CDKN2A
28 reflex sympathetic dystrophy 9.7 ADRB2 ADRA2C ADRA2B ADRA1B ADRA1A
29 seminal vesicle tumor 9.5 OGFRL1 KLK3 CCDC115 C4orf47
30 orthostatic intolerance 9.5 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
31 suppression of tumorigenicity 12 9.5 SERPINA3 KLK3 CDKN2A
32 asthma 9.3 SERPINA3 KLK3 ADRB3 ADRB2 ADRB1 ADRA1B
33 attention deficit-hyperactivity disorder 9.3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1A
34 dilated cardiomyopathy 9.3 SERPINA3 ADRB3 ADRB2 ADRB1 ADRA2C ADRA1D
35 pheochromocytoma 9.3 CDKN2A ADRB3 ADRB2 ADRA2C
36 prostatic hypertrophy 9.3 SERPINA3 KLK3 ADRA2C ADRA2B ADRA2A ADRA1D
37 sexual disorder 9.3 SERPINA3 KLK3 ADRA2C ADRA2B ADRA2A ADRA1D
38 ocular hypotension 9.2 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1B
39 coronary artery vasospasm 9.2 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1B
40 agnosia 8.8 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
41 pain agnosia 8.8 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
42 hypertension, essential 8.6 SERPINA3 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B

Graphical network of the top 20 diseases related to Male Reproductive Organ Benign Neoplasm:



Diseases related to Male Reproductive Organ Benign Neoplasm

Symptoms & Phenotypes for Male Reproductive Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 8.92 ADRA1A ADRA1B ADRA1D ADRA2B

MGI Mouse Phenotypes related to Male Reproductive Organ Benign Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C
2 cardiovascular system MP:0005385 9.85 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C
3 homeostasis/metabolism MP:0005376 9.7 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C ADRB1
4 muscle MP:0005369 9.28 ADRA1A ADRA1B ADRA1D ADRA2B ADRB1 ADRB2

Drugs & Therapeutics for Male Reproductive Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Male Reproductive Organ Benign Neoplasm

Genetic Tests for Male Reproductive Organ Benign Neoplasm

Anatomical Context for Male Reproductive Organ Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Male Reproductive Organ Benign Neoplasm:

19
Male Reproductive System

Publications for Male Reproductive Organ Benign Neoplasm

Variations for Male Reproductive Organ Benign Neoplasm

Expression for Male Reproductive Organ Benign Neoplasm

Search GEO for disease gene expression data for Male Reproductive Organ Benign Neoplasm.

Pathways for Male Reproductive Organ Benign Neoplasm

Pathways related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 KLK3 CLIP3 ADRB3 ADRB2 ADRB1 ADRA2C
2
Show member pathways
13.41 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
3
Show member pathways
13.36 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
4
Show member pathways
12.71 ADRB2 ADRB1 ADRA2B ADRA2A ADRA1B ADRA1A
5
Show member pathways
12.37 ADRB3 ADRB2 ADRB1 ADRA1D ADRA1B ADRA1A
6
Show member pathways
12.36 ADRB2 ADRA2C ADRA2B ADRA2A
7
Show member pathways
12.31 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
8
Show member pathways
12.15 ADRB3 ADRB2 ADRB1 ADRA1D ADRA1B ADRA1A
9
Show member pathways
12.03 ADRA2C ADRA2B ADRA2A ADRA1D ADRA1B ADRA1A
10
Show member pathways
11.96 ADRB3 ADRB2 ADRB1 ADRA1D ADRA1B ADRA1A
11 11.92 ADRB3 ADRB2 ADRB1
12
Show member pathways
11.83 ADRA1D ADRA1B ADRA1A
13
Show member pathways
11.7 ADRA2C ADRA2B ADRA2A
14 11.54 ADRB3 ADRB2 ADRB1
15 11.48 ADRB2 ADRB1 ADRA2A ADRA1D
16 11.43 ADRB3 ADRB2 ADRB1
17
Show member pathways
11.32 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
18 10.92 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1D

GO Terms for Male Reproductive Organ Benign Neoplasm

Cellular components related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.9 SLITRK2 CLIP3 ADRB3 ADRB2 ADRB1 ADRA2C
2 integral component of plasma membrane GO:0005887 9.28 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
3 integral component of postsynaptic membrane GO:0099055 9.13 SLITRK2 ADRA2C ADRA1A

Biological processes related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.25 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
2 G protein-coupled receptor signaling pathway GO:0007186 10.19 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
3 cell-cell signaling GO:0007267 9.97 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
4 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.88 ADRB3 ADRB2 ADRB1 ADRA2A
5 positive regulation of MAPK cascade GO:0043410 9.86 ADRB3 ADRB2 ADRA2C ADRA2B ADRA2A ADRA1D
6 positive regulation of cytosolic calcium ion concentration GO:0007204 9.83 ADRA1D ADRA1B ADRA1A
7 positive regulation of vasoconstriction GO:0045907 9.83 ADRA2C ADRA1D ADRA1B ADRA1A
8 platelet activation GO:0030168 9.81 ADRA2C ADRA2B ADRA2A
9 positive regulation of cold-induced thermogenesis GO:0120162 9.81 ADRB3 ADRB2 ADRB1
10 regulation of vasoconstriction GO:0019229 9.8 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A
11 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.79 ADRA1D ADRA1B ADRA1A
12 activation of adenylate cyclase activity GO:0007190 9.79 ADRB3 ADRB2 ADRB1
13 activation of protein kinase B activity GO:0032148 9.77 ADRA2C ADRA2B ADRA2A
14 adrenergic receptor signaling pathway GO:0071875 9.76 ADRB3 ADRB2 ADRA2C ADRA2B ADRA2A ADRA1D
15 positive regulation of smooth muscle contraction GO:0045987 9.73 ADRA1D ADRA1B ADRA1A
16 regulation of smooth muscle contraction GO:0006940 9.73 ADRB2 ADRA2C ADRA2B ADRA2A
17 negative regulation of norepinephrine secretion GO:0010700 9.72 ADRA2C ADRA2B ADRA2A
18 receptor transactivation GO:0035624 9.69 ADRA2C ADRA2B ADRA2A
19 negative regulation of epinephrine secretion GO:0032811 9.67 ADRA2C ADRA2B ADRA2A
20 positive regulation of heart rate by epinephrine-norepinephrine GO:0001996 9.67 ADRB1 ADRA1D ADRA1B ADRA1A
21 temperature homeostasis GO:0001659 9.65 ADRB3 ADRB1
22 regulation of cardiac muscle contraction GO:0055117 9.65 ADRA1B ADRA1A
23 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure GO:0001994 9.65 ADRA1D ADRA1B ADRA1A
24 regulation of muscle contraction GO:0006937 9.64 ADRA1B ADRA1A
25 negative regulation of multicellular organism growth GO:0040015 9.63 ADRB2 ADRB1
26 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure GO:0002025 9.63 ADRB3 ADRB2 ADRB1
27 diet induced thermogenesis GO:0002024 9.62 ADRB2 ADRB1
28 desensitization of G protein-coupled receptor signaling pathway by arrestin GO:0002032 9.61 ADRB3 ADRB2
29 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.61 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
30 heat generation GO:0031649 9.58 ADRB2 ADRB1
31 positive regulation of the force of heart contraction by epinephrine-norepinephrine GO:0001997 9.57 ADRB1 ADRA1A
32 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.28 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A

Molecular functions related to Male Reproductive Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.91 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
2 protein heterodimerization activity GO:0046982 9.83 ADRB1 ADRA2C ADRA2A ADRA1B ADRA1A
3 alpha2-adrenergic receptor activity GO:0004938 9.54 ADRA2C ADRA2B ADRA2A
4 alpha1-adrenergic receptor activity GO:0004937 9.5 ADRA1D ADRA1B ADRA1A
5 alpha-2A adrenergic receptor binding GO:0031694 9.46 ADRB1 ADRA2C
6 norepinephrine binding GO:0051380 9.46 ADRB3 ADRB2 ADRB1 ADRA2A
7 epinephrine binding GO:0051379 9.43 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A
8 beta-adrenergic receptor activity GO:0004939 9.4 ADRB3 ADRB1
9 adrenergic receptor activity GO:0004935 9.28 ADRB3 ADRB2 ADRB1 ADRA2C ADRA2B ADRA2A

Sources for Male Reproductive Organ Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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