MCID: MLR006
MIFTS: 45

Male Reproductive Organ Cancer

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Male Reproductive Organ Cancer

MalaCards integrated aliases for Male Reproductive Organ Cancer:

Name: Male Reproductive Organ Cancer 12 15
Genital Neoplasms, Male 44 73
Malignant Neoplasm of Male Genital Organ or Tract 12
Malignant Tumor of Male Reproductive System 12
Malignant Neoplasm of Male Genital Organs 12
Malignant Neoplasm of Male Genital Organ 12
Malignant Tumor of Male Genital Organ 12
Male Reproductive System Neoplasm 12
Tumor of Male Reproductive System 12
Neoplasm of Male Genital Organ 12
Male Genital Neoplasm 12
Male Genital Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3856
ICD9CM 35 187.9
MeSH 44 D005834
NCIt 50 C3054 C8561
SNOMED-CT 68 93885006

Summaries for Male Reproductive Organ Cancer

Disease Ontology : 12 A reproductive organ cancer that is manifested in the male genital system. This includes organs such as the penis and scrotum.

MalaCards based summary : Male Reproductive Organ Cancer, also known as genital neoplasms, male, is related to prostate cancer and seminal vesicle adenocarcinoma. An important gene associated with Male Reproductive Organ Cancer is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways are Metabolism of proteins and Phospholipase-C Pathway. Affiliated tissues include prostate, lung and bone, and related phenotypes are growth/size/body region and homeostasis/metabolism

Related Diseases for Male Reproductive Organ Cancer

Diseases in the Male Reproductive Organ Cancer family:

Male Reproductive Organ Benign Neoplasm

Diseases related to Male Reproductive Organ Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 prostate cancer 31.4 AKT1 AMACR AR CDH1 CYP17A1 FOLH1
2 seminal vesicle adenocarcinoma 11.2
3 littre gland carcinoma 11.2
4 cowper gland carcinoma 11.2
5 penis squamous cell carcinoma 10.7
6 paratesticular adenocarcinoma 10.7
7 adenocarcinoma of the penis 10.7
8 penile cancer 10.6
9 testicular germ cell tumor 10.5
10 testicular cancer 10.5
11 submandibular gland cancer 10.4 KLK3 TP53
12 small cell carcinoma 10.4 KLK3 PTEN TP53
13 nodular prostate 10.4 AR FOLH1 KLK3
14 epididymis cancer 10.3
15 glans penis cancer 10.3
16 malignant tumor of undescended testis 10.3
17 prepuce cancer 10.3
18 spermatic cord cancer 10.3
19 sex cord-gonadal stromal tumor 10.3
20 scrotal carcinoma 10.3
21 penile cancer, adult 10.3
22 nephrogenic adenoma 10.3 AMACR KLK3 NKX3-1
23 urethral diverticulum 10.3 AMACR KLK3 NKX3-1
24 prostatic hyperplasia, benign 10.3 AR CYP17A1 FOLH1 KLK3
25 prostate small cell carcinoma 10.3 AMACR FOLH1 KLK3 PTEN
26 prostatic acinar adenocarcinoma 10.3 AMACR KLK3 NKX3-1 TMPRSS2
27 bartholin's duct cyst 10.3 AR TP53
28 supratentorial cancer 10.3 AKT1 PTEN TP53
29 bile duct adenocarcinoma 10.3 AKT1 CDH1 TP53
30 cerebrum cancer 10.3 AKT1 PTEN TP53
31 nasopharyngeal disease 10.3 AKT1 CDH1 TP53
32 atrophy of prostate 10.3 KLK3 TP53
33 pharynx cancer 10.3 AKT1 CDH1 TP53
34 adenocarcinoma 10.3 AKT1 CDH1 PTEN TP53
35 prostate sarcoma 10.3 KLK3 NKX3-1
36 central nervous system cancer 10.3 AKT1 PTEN TP53
37 bladder disease 10.3 AKT1 CDH1 KLK3 TP53
38 nervous system cancer 10.3 AKT1 PTEN TP53
39 ductal carcinoma in situ 10.3 AKT1 AR CDH1 TP53
40 connective tissue cancer 10.3 AKT1 AREG TP53
41 meningioma, familial 10.3 AKT1 CDH1 PTEN TP53
42 rare adenocarcinoma of the breast 10.3 AKT1 TP53
43 anaplastic thyroid cancer 10.3 CDH1 PTEN TP53
44 ovarian cancer 1 10.3 AKT1 AREG CDH1 TP53
45 ovarian disease 10.3 AKT1 IGF1 PTEN TP53
46 malignant ovarian surface epithelial-stromal neoplasm 10.3 AKT1 AREG CDH1 TP53
47 pancreas disease 10.3 AKT1 AREG IGF1 TP53
48 ovary epithelial cancer 10.3 AKT1 AREG CDH1 TP53
49 transitional cell carcinoma 10.3 CDH1 PSCA PTEN TP53
50 cervix disease 10.3 AKT1 AREG CDH1 TP53

Graphical network of the top 20 diseases related to Male Reproductive Organ Cancer:



Diseases related to Male Reproductive Organ Cancer

Symptoms & Phenotypes for Male Reproductive Organ Cancer

MGI Mouse Phenotypes related to Male Reproductive Organ Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.06 AKT1 AMACR AR AREG CDH1 CYP17A1
2 homeostasis/metabolism MP:0005376 10.03 AKT1 AMACR AR AREG CDH1 CYP17A1
3 endocrine/exocrine gland MP:0005379 10.02 AKT1 AR AREG CDH1 IGF1 NKX3-1
4 adipose tissue MP:0005375 9.95 AKT1 AMACR AR CYP17A1 IGF1 PTEN
5 mortality/aging MP:0010768 9.93 AKT1 AMACR AR AREG CDH1 CYP17A1
6 neoplasm MP:0002006 9.61 AKT1 AR CDH1 IGF1 NKX3-1 PSCA
7 reproductive system MP:0005389 9.32 AKT1 AR AREG CDH1 CYP17A1 IGF1

Drugs & Therapeutics for Male Reproductive Organ Cancer

Search Clinical Trials , NIH Clinical Center for Male Reproductive Organ Cancer

Cochrane evidence based reviews: genital neoplasms, male

Genetic Tests for Male Reproductive Organ Cancer

Anatomical Context for Male Reproductive Organ Cancer

MalaCards organs/tissues related to Male Reproductive Organ Cancer:

41
Prostate, Lung, Bone, Colon, Tongue, Ovary, Thyroid

Publications for Male Reproductive Organ Cancer

Variations for Male Reproductive Organ Cancer

Expression for Male Reproductive Organ Cancer

Search GEO for disease gene expression data for Male Reproductive Organ Cancer.

Pathways for Male Reproductive Organ Cancer

Pathways related to Male Reproductive Organ Cancer according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 AR AREG GRP IGF1 KLK2 KLK3
2
Show member pathways
12.99 AKT1 AREG IGF1 PSMA1 PTEN TP53
3
Show member pathways
12.63 AKT1 CDH1 PTEN SHC4 TP53
4
Show member pathways
12.63 AKT1 CDH1 IGF1 PTEN SHC4 TP53
5
Show member pathways
12.6 AKT1 CDH1 IGF1 PTEN SHC4 TP53
6 12.48 AKT1 AR CDH1 IGF1 KLK3 NKX3-1
7
Show member pathways
12.42 AKT1 IGF1 PTEN TP53
8
Show member pathways
12.41 AKT1 AREG CDH1 SHC4 TP53
9
Show member pathways
12.4 AKT1 CYP17A1 PTEN SHC4
10
Show member pathways
12.39 AKT1 AREG SHC4 TP53
11 12.34 AKT1 CDH1 PSMA1 TP53
12
Show member pathways
12.31 AKT1 IGF1 PTEN TP53
13
Show member pathways
12.14 AKT1 PSMA1 PTEN TP53
14
Show member pathways
12.13 AKT1 AREG PTEN SHC4
15
Show member pathways
12.11 AKT1 AR AREG CDH1 IGF1 KLK3
16 11.95 AKT1 AR CDH1 PTEN TP53
17
Show member pathways
11.88 AKT1 AR IGF1 KLK3 PTEN
18 11.86 IGF1 PTEN TP53
19 11.84 AKT1 IGF1 PTEN TP53
20 11.78 AKT1 PTEN TP53
21 11.74 AKT1 PTEN TP53
22 11.69 AKT1 AR KLK3 PTEN
23 11.61 AKT1 PTEN TP53
24 11.6 AKT1 PTEN TP53
25 11.56 IGF1 KLK2 KLK3
26 11.5 AKT1 PTEN TP53
27 11.42 KLK2 KLK3 KLK4
28
Show member pathways
11.39 AR KLK3 NKX3-1
29 11.38 AKT1 PTEN TP53
30 11.26 AR KLK2 KLK3 TMPRSS2
31 11.19 AKT1 AR KLK2 KLK3 NKX3-1 TMPRSS2
32 11.18 AKT1 IGF1 PTEN
33 10.9 IGF1 KLK2 KLK3

GO Terms for Male Reproductive Organ Cancer

Cellular components related to Male Reproductive Organ Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.28 CDH1 GRP IGF1 KLK2 KLK3 KLK4
2 secretory granule GO:0030141 9.13 KLK2 KLK3 KLK4

Biological processes related to Male Reproductive Organ Cancer according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.95 FOLH1 KLK2 KLK3 KLK4 PSMA1 TMPRSS2
2 positive regulation of transcription, DNA-templated GO:0045893 9.91 AKT1 AR CDH1 IGF1 NKX3-1 TP53
3 protein deubiquitination GO:0016579 9.83 AR PSMA1 PTEN TP53
4 positive regulation of gene expression GO:0010628 9.8 AKT1 AR IGF1 NKX3-1 PTEN TP53
5 response to organic substance GO:0010033 9.74 AKT1 CDH1 PTEN
6 cell proliferation GO:0008283 9.73 AKT1 AR AREG IGF1 PTEN TP53
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.71 AREG IGF1 TP53
8 negative regulation of epithelial cell proliferation GO:0050680 9.67 AR NKX3-1 PTEN
9 cellular response to hypoxia GO:0071456 9.67 AKT1 NKX3-1 PTEN TP53
10 zymogen activation GO:0031638 9.59 KLK2 KLK3
11 prostate gland development GO:0030850 9.58 AR NKX3-1
12 insulin-like growth factor receptor signaling pathway GO:0048009 9.58 AKT1 IGF1
13 cellular response to steroid hormone stimulus GO:0071383 9.56 AR NKX3-1
14 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.55 AR IGF1
15 negative regulation of cell size GO:0045792 9.51 AKT1 PTEN
16 positive regulation of cell proliferation GO:0008284 9.5 AKT1 AR AREG IGF1 NKX3-1 PTEN
17 prostate gland growth GO:0060736 9.46 AR PTEN
18 cellular response to decreased oxygen levels GO:0036294 9.4 AKT1 PTEN
19 regulation of systemic arterial blood pressure GO:0003073 9.33 AR KLK2 KLK3
20 protein kinase B signaling GO:0043491 8.92 AKT1 IGF1 NKX3-1 PTEN

Molecular functions related to Male Reproductive Organ Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.56 KLK2 KLK3 KLK4 TMPRSS2
2 serine-type peptidase activity GO:0008236 9.46 KLK2 KLK3 KLK4 TMPRSS2
3 GTPase activating protein binding GO:0032794 9.32 AKT1 CDH1
4 peptidase activity GO:0008233 9.1 FOLH1 KLK2 KLK3 KLK4 PSMA1 TMPRSS2
5 androgen receptor activity GO:0004882 8.96 AR NKX3-1

Sources for Male Reproductive Organ Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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